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Aliases for PTPN11 Gene

Aliases for PTPN11 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 2 3 5
  • Protein-Tyrosine Phosphatase 1D 3 4
  • Protein-Tyrosine Phosphatase 2C 3 4
  • EC 3.1.3.48 4 63
  • SH-PTP2 3 4
  • SH-PTP3 3 4
  • PTP-1D 3 4
  • PTP-2C 3 4
  • PTP2C 3 4
  • SHP2 3 4
  • Noonan Syndrome 1 2
  • METCDS 3
  • SHPTP2 4
  • BPTP3 3
  • SHP-2 4
  • JMML 3
  • NS1 3
  • CFC 3

External Ids for PTPN11 Gene

Previous HGNC Symbols for PTPN11 Gene

  • NS1

Previous GeneCards Identifiers for PTPN11 Gene

  • GC12P111712
  • GC12P112333
  • GC12P112639
  • GC12P111268
  • GC12P111319
  • GC12P112856
  • GC12P109868

Summaries for PTPN11 Gene

Entrez Gene Summary for PTPN11 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PTPN11 Gene

PTPN11 (Protein Tyrosine Phosphatase, Non-Receptor Type 11) is a Protein Coding gene. Diseases associated with PTPN11 include noonan syndrome 1 and leukemia, acute myelomonocytic, somatic, somatic. Among its related pathways are Adipocytokine signaling pathway and Axon guidance. GO annotations related to this gene include protein domain specific binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPN11 Gene

  • Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

Tocris Summary for PTPN11 Gene

  • Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinase and phosphorylase enzymes.

Gene Wiki entry for PTPN11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN11 Gene

Genomics for PTPN11 Gene

Regulatory Elements for PTPN11 Gene

Enhancers for PTPN11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTPN11 on UCSC Golden Path with GeneCards custom track

Promoters for PTPN11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPN11 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPN11 Gene

Chromosome:
12
Start:
112,418,351 bp from pter
End:
112,509,918 bp from pter
Size:
91,568 bases
Orientation:
Plus strand

Genomic View for PTPN11 Gene

Genes around PTPN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN11 Gene

Proteins for PTPN11 Gene

  • Protein details for PTPN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06124-PTN11_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 11
    Protein Accession:
    Q06124
    Secondary Accessions:
    • A8K1D9
    • Q96HD7

    Protein attributes for PTPN11 Gene

    Size:
    597 amino acids
    Molecular mass:
    68436 Da
    Quaternary structure:
    • Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity. Interacts with GAREM1 isoform 1 (tyrosine phosphorylated); the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation.

    Three dimensional structures from OCA and Proteopedia for PTPN11 Gene

    Alternative splice isoforms for PTPN11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN11 Gene

Proteomics data for PTPN11 Gene at MOPED

Post-translational modifications for PTPN11 Gene

  • Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
  • Ubiquitination at Lys 594
  • Modification sites at PhosphoSitePlus

Other Protein References for PTPN11 Gene

Domains & Families for PTPN11 Gene

Graphical View of Domain Structure for InterPro Entry

Q06124

UniProtKB/Swiss-Prot:

PTN11_HUMAN :
  • The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Domain:
  • The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme.
  • Contains 2 SH2 domains.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
genes like me logo Genes that share domains with PTPN11: view

Function for PTPN11 Gene

Molecular function for PTPN11 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 11,with two SH2 domains,expressed in heart,brain,skeletal muscle with homology to Drosophila corkscrew,involved in intracellular signal transduction in response to PDGF,EGF,insulin,interacting with protein zero related (PZR) for cell signaling,overexpressed in neutrophils cells from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in signaling pathways)
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

Enzyme Numbers (IUBMB) for PTPN11 Gene

Gene Ontology (GO) - Molecular Function for PTPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7493946
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with PTPN11: view
genes like me logo Genes that share phenotypes with PTPN11: view

Human Phenotype Ontology for PTPN11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPN11 Gene

MGI Knock Outs for PTPN11:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for PTPN11 Gene

Localization for PTPN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN11 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN11 Gene COMPARTMENTS Subcellular localization image for PTPN11 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 2
extracellular 2
plasma membrane 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PTPN11 Gene

Pathways & Interactions for PTPN11 Gene

SuperPathways for PTPN11 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 MyD88 cascade initiated on plasma membrane
4 Development HGF signaling pathway
5 Negative regulation of FGFR1 signaling
genes like me logo Genes that share pathways with PTPN11: view

SIGNOR curated interactions for PTPN11 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007173 epidermal growth factor receptor signaling pathway IEA,TAS --
GO:0007229 integrin-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with PTPN11: view

Drugs & Compounds for PTPN11 Gene

(37) Drugs for PTPN11 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dodecane-Trimethylamine Experimental Pharma Target 0
sodium orthovanadate Pharma PTP inhibitor, Protein tyrosine phosphatase inhibitor 0
Etidronate Pharma Osteoclast function modifiers (important in bone metastasis) 0
STIBOGLUCONATE Pharma 0

(32) Additional Compounds for PTPN11 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
BVT 948
39674-97-0
NSC 87877
56990-57-9

(5) Tocris Compounds for PTPN11 Gene

Compound Action Cas Number
BVT 948 Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling 39674-97-0
NSC 87877 Potent inhibitor of shp2 and shp1 PTP 56990-57-9
Sodium orthovanadate Protein tyrosine phosphatase inhibitor 13721-39-6
TCS 401 Selective inhibitor of PTP1B 243966-09-8
VO-OHpic Potent PTEN inhibitor 675848-25-6

(1) ApexBio Compounds for PTPN11 Gene

Compound Action Cas Number
Etidronate 2809-21-4
genes like me logo Genes that share compounds with PTPN11: view

Drug Products

Transcripts for PTPN11 Gene

Unigene Clusters for PTPN11 Gene

Protein tyrosine phosphatase, non-receptor type 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN11 Gene

No ASD Table

Relevant External Links for PTPN11 Gene

GeneLoc Exon Structure for
PTPN11
ECgene alternative splicing isoforms for
PTPN11

Expression for PTPN11 Gene

mRNA expression in normal human tissues for PTPN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9), Frontal cortex (8.0), and Breast (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN11 Gene



SOURCE GeneReport for Unigene cluster for PTPN11 Gene Hs.506852

mRNA Expression by UniProt/SwissProt for PTPN11 Gene

Q06124-PTN11_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle.
genes like me logo Genes that share expression patterns with PTPN11: view

Protein tissue co-expression partners for PTPN11 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for PTPN11 Gene

Orthologs for PTPN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPN11 35
  • 93.54 (n)
  • 98.99 (a)
PTPN11 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN11 35
  • 93.93 (n)
  • 99.33 (a)
PTPN11 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn11 35
  • 87.24 (n)
  • 99.49 (a)
Ptpn11 16
Ptpn11 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPN11 35
  • 99.71 (n)
  • 100 (a)
PTPN11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn11 35
  • 87.46 (n)
  • 98.99 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPN11 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN11 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN11 35
  • 85.33 (n)
  • 98.31 (a)
PTPN11 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN11 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16002 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.936 35
zebrafish
(Danio rerio)
Actinopterygii ptpn11a 35
  • 77.68 (n)
  • 91.57 (a)
wufi24f03 35
ptpn11a 36
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta csw 37
  • 66 (a)
csw 35
  • 61.59 (n)
  • 66.8 (a)
csw 36
  • 31 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002438 35
  • 60.06 (n)
  • 65.23 (a)
worm
(Caenorhabditis elegans)
Secernentea C55B7.3 37
  • 31 (a)
F47B3.7 37
  • 34 (a)
ptp-2 37
  • 37 (a)
ptp-2 36
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6771 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for PTPN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN11 Gene

ENSEMBL:
Gene Tree for PTPN11 (if available)
TreeFam:
Gene Tree for PTPN11 (if available)

Paralogs for PTPN11 Gene

Paralogs for PTPN11 Gene

(18) SIMAP similar genes for PTPN11 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PTPN11: view

Variants for PTPN11 Gene

Sequence variations from dbSNP and Humsavar for PTPN11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_015601 Noonan syndrome 1 (NS1)
VAR_015602 Noonan syndrome 1 (NS1)
VAR_015603 Noonan syndrome 1 (NS1)
VAR_015604 Noonan syndrome 1 (NS1)
VAR_015605 Noonan syndrome 1 (NS1)

Structural Variations from Database of Genomic Variants (DGV) for PTPN11 Gene

Variant ID Type Subtype PubMed ID
esv2661618 CNV Deletion 23128226
esv2746369 CNV Deletion 23290073
nsv889 CNV Loss 18451855
nsv899524 CNV Gain 21882294

Variation tolerance for PTPN11 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN11 Gene

HapMap Linkage Disequilibrium report
PTPN11
Human Gene Mutation Database (HGMD)
PTPN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN11 Gene

Disorders for PTPN11 Gene

MalaCards: The human disease database

(44) MalaCards diseases for PTPN11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
noonan syndrome 1
  • noonan syndrome
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
leopard syndrome 1
  • leopard syndrome
metachondromatosis
  • metcds
ptpn11-related noonan syndrome
  • noonan syndrome 1
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PTN11_HUMAN
  • LEOPARD syndrome 1 (LPRD1) [MIM:151100]: A disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness. {ECO:0000269 PubMed:12058348, ECO:0000269 PubMed:14961557, ECO:0000269 PubMed:15121796, ECO:0000269 PubMed:15389709, ECO:0000269 PubMed:15520399, ECO:0000269 PubMed:15690106, ECO:0000269 PubMed:16679933, ECO:0000269 PubMed:24891296}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. {ECO:0000269 PubMed:12717436}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Metachondromatosis (MC) [MIM:156250]: A skeletal disorder with radiologic features of both multiple exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and feet, and enchondromas of the metaphyses of long bones and iliac crest. {ECO:0000269 PubMed:20577567}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Noonan syndrome 1 (NS1) [MIM:163950]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints. {ECO:0000269 PubMed:11704759, ECO:0000269 PubMed:11992261, ECO:0000269 PubMed:12161469, ECO:0000269 PubMed:12325025, ECO:0000269 PubMed:12529711, ECO:0000269 PubMed:12634870, ECO:0000269 PubMed:12717436, ECO:0000269 PubMed:12739139, ECO:0000269 PubMed:12960218, ECO:0000269 PubMed:15384080, ECO:0000269 PubMed:15948193, ECO:0000269 PubMed:19020799, ECO:0000269 PubMed:24891296}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in PTPN11 account for more than 50% of the cases.

Relevant External Links for PTPN11

Genetic Association Database (GAD)
PTPN11
Human Genome Epidemiology (HuGE) Navigator
PTPN11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN11
genes like me logo Genes that share disorders with PTPN11: view

No data available for Genatlas for PTPN11 Gene

Publications for PTPN11 Gene

  1. PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. (PMID: 19020799) Ko J.M. … Yoo H.W. (J. Hum. Genet. 2008) 3 4 48 67
  2. Identification of a human src homology 2-containing protein-tyrosine- phosphatase: a putative homolog of Drosophila corkscrew. (PMID: 1280823) Freeman R.M. Jr. … Neel B.G. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 23
  3. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). (PMID: 20170098) Zhang X. … Zhang Z.Y. (J. Med. Chem. 2010) 3 23
  4. Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling. (PMID: 20308328) Edouard T. … Raynal P. (Mol. Cell. Biol. 2010) 3 23
  5. Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica. (PMID: 20398180) Kim K.A. … Shin M.H. (Parasite Immunol. 2010) 3 23

Products for PTPN11 Gene

Sources for PTPN11 Gene

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