Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTPN11 Gene

protein-coding GIFtS: 73
GCID: GC12P112856

protein tyrosine phosphatase, non-receptor type 11

(Previous name: Noonan syndrome 1 )
(Previous symbol: NS1)

Explore 117 diseases affiliated with
PTPN11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 11¹ ²		PTP-1D² ³
PTP2C¹ ² ³ ⁵		PTP-2C² ³
SH-PTP2¹ ² ³		SH-PTP3² ³
NS1¹ ² ⁵		EC 3.1.3.48³ ⁸
SHP2¹ ² ⁵		Noonan Syndrome 1¹
BPTP3¹ ²		CFC²
SHP-2¹ ³		Tyrosine-Protein Phosphatase Non-Receptor Type 11²
Protein-Tyrosine Phosphatase 1D² ³		SHPTP2³
Protein-Tyrosine Phosphatase 2C² ³		Shp2³

External Ids:	HGNC: 9644¹	Entrez Gene: 5781²	Ensembl: ENSG00000179295⁷	OMIM: 176876⁵	UniProtKB: Q06124³

Export aliases for PTPN11 gene to outside databases

Previous GC identifers: GC12P111712 GC12P112333 GC12P112639 GC12P111268 GC12P111319 GC12P109868

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN11:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be

signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic

cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as

phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely

expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a

diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell

migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal

transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its

RhoA binding activity

summary for PTPN11:

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups

from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of

kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs

are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.

PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity

phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.

MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been

implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator

of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In

cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTPN11 gene promoter:
AP-2alpha isoform 3 STAT3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPN11 promoter sequence

Search SABiosciences Chromatin IP Primers for PTPN11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.13 HGNC cytogenetic band: 12q24.1

PTPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN11 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P112856: view genomic region (about GC identifiers)

Start:	112,856,155 bp from pter	End:	112,947,717 bp from pter
Size:	91,563 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124 (See protein sequence)

Recommended Name: Tyrosine-protein phosphatase non-receptor type 11

Size: 597 amino acids; 68436 Da

Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity). Interacts

with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated),

FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2

domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with

phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction

is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts

with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream

signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this

interaction increases the PTPN11 phosphatase activity. Interacts with GAREM isoform 1 (tyrosine phosphorylated); the

interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation

Subcellular location: Cytoplasm

6 PDB 3D structures from and Proteopedia for PTPN11:

2SHP (3D)

3B7O (3D)

3MOW (3D)

3O5X (3D)

3TKZ (3D)

3TL0 (3D)

Secondary accessions: A8K1D9 Q96HD7

Alternative splicing: 3 isoforms: Q06124-1 Q06124-2 Q06124-3

Explore the universe of human proteins at neXtProt for PTPN11: NX_Q06124

Post-translational modifications:

Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site

for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3.

Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q06124

4/20 DME Specific Peptides for PTPN11 (Q06124) (see all 20)

WPDHGVP

SRRWFHP

DPTSERW

VVHCSAG

PTPN11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002825.3 NP_542168.1

ENSEMBL proteins:

ENSP00000376376 ENSP00000340944 ENSP00000437013

Reactome Protein details: Q06124
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PTPN11 Protein
	R&D Systems Recombinant & Natural Proteins for PTPN11 (SHP-2)
	Enzo Life Sciences proteins for PTPN11
	OriGene Purified Protein: PTPN11 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for PTPN11
	GenScript Custom Purified and Recombinant Proteins Services for PTPN11
	Novus Biologicals PTPN11 Proteins Novus Biologicals PTPN11 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTPN11

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IDA	10940933
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--
GO:0043234	protein complex	IEA	--

PTPN11 for ontologies About GeneDecksing

PTPN11 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
	R&D Systems Antibodies for PTPN11 (SHP-2)
	Cell Signaling Technology (CST) Antibodies for PTPN11 (SHP-2)
	OriGene Antibodies (see all 11): PTPN11 OriGene Custom Antibody Services for PTPN11
	GenScript Custom Superior Antibodies Services for PTPN11
	Novus Biologicals PTPN11 Antibodies
	Abcam antibodies for PTPN11
	Uscn Antibodies for PTPN11
	ThermoFisher Antibodies for PTPN11

Assay Products for PTPN11:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for PTPN11 (SHP-2) (see all)
	GenScript Custom Assay Services for PTPN11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTPN11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTPN11 for domains About GeneDecksing

5 InterPro domains/families:

IPR016130 Tyr_Pase_AS

IPR000242 Tyr_Pase_rcpt/non-rcpt

IPR000387 Tyr/Dual-sp_Pase

IPR000980 SH2

IPR012152 Tyr_Pase_non-rcpt_typ-6/11

Graphical View of Domain Structure for InterPro Entry Q06124

ProtoNet protein and cluster: Q06124

2 Blocks protein families:

IPB000242 Protein tyrosine phosphatase signature

IPB000980 SH2 domain signature

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Domain: The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins

relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal

transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its

RhoA binding activity

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Genatlas biochemistry entry for PTPN11:

protein tyrosine phosphatase,non receptor type 11,with two SH2 domains,expressed in heart,brain,skeletal muscle with

homology to Drosophila corkscrew,involved in intracellular signal transduction in response to

PDGF,EGF,insulin,interacting with protein zero related (PZR) for cell signaling,overexpressed in neutrophils cells

from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in signaling

pathways)

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

miRNA Products:		miRTarBase miRNAs that target PTPN11: hsa-mir-489 (MIRT003549)

		OriGene 3'-UTR Clone: PTPN11 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN11
		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
		hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11 (see all 7) OriGene shRNA RFP: PTPN11 OriGene siRNA: PTPN11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PTPN11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTPN11
		Search LifeMap BioReagents cell lines for PTPN11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004721	phosphoprotein phosphatase activity	--	--
GO:0004725	protein tyrosine phosphatase activity	TAS	--
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	TAS	--
GO:0005070	SH3/SH2 adaptor activity	IDA	7493946
GO:0005158	insulin receptor binding	IPI	7493946

PTPN11 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for PTPN11:

Decreased focal adhesion (FA)

Increased cell death in breast

Increased cell number in G2M,

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-outs for PTPN11: Ptpn11^tm1Rbn Ptpn11^tm2Bgn Ptpn11^tm1.2Cbm Ptpn11^tm1Paw
15/26 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Ptpn11) (see all 26):

adipose tissue	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system

PTPN11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/88 super-pathways (see all 88) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

Development_CNTF receptor signaling

8/9 pathways (see all 9)
Development_CNTF receptor signaling	1.00	Immune response_IL-6 signaling pathway	0.30
Development CNTF receptor signaling	1.00	Immune response IL-6 signaling pathway	0.30
Development_Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34	Development_Leptin signaling via JAK/STAT and MAPK cascades	0.25
Development Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34	Development Leptin signaling via JAK/STAT and MAPK cascades	0.25

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Development HGF signaling pathway

Development_Neurotrophin family signaling	0.45	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23
Development Neurotrophin family signaling	0.45	Neurotrophin signaling pathway	0.20
Signaling of Hepatocyte Growth Factor Receptor	0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

5/22 EMD Millipore Pathways for PTPN11 (see all 22)

	Chemotaxis CXCR4 signaling pathway
	Development Leptin signaling via JAK/STAT and MAPK cascades
	Immune response Role of DAP12 receptors in NK cells
	Immune response IL-2 activation and signaling pathway
	Development Growth hormone signaling via PI3K/AKT and MAPK cascades

1 R&D Systems Pathway for PTPN11

Adipocytokines & Insulin Signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN11

Epithelial Adherens Junctions

3 Cell Signaling Technology (CST) Pathways for PTPN11

	Phosphatases
	MAP Kinase Signaling
	Apoptosis and Autophagy

5/24 GeneGo (Thomson Reuters) Pathways for PTPN11 (see all 24)

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development FGF-family signaling
	Development CNTF receptor signaling
	Development Thrombopoetin signaling via JAK-STAT pathway
	Chemotaxis CXCR4 signaling pathway

5/44 BioSystems Pathways for PTPN11 (see all 44)

	Oncostatin M Signaling Pathway
	EGFR1 Signaling Pathway
	Heart Development
	Type II interferon signaling (IFNG)
	IL-3 Signaling Pathway

5/67 Reactome Pathways for PTPN11 (see all 67)

	Platelet homeostasis
	Prolactin receptor signaling
	Regulation of IFNG signaling
	IRS-mediated signalling
	Signaling by PDGF

5/8 Kegg Pathways (Kegg details for PTPN11) (see all 8):

	Jak-STAT signaling pathway
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Neurotrophin signaling pathway
	Adipocytokine signaling pathway

PTPN11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTPN11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/329 Interacting proteins for PTPN11 (Q06124^{1, 2, 3} ENSP00000340944⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 329)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GAB1	Q13480¹^,²^,³, ENSP00000262995⁴	EBI-297779,EBI-517684 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000262995
GRB2	P62993¹^,²^,³, ENSP00000339007⁴	EBI-297779,EBI-401755 MINT-7300447 MINT-61552 I2D: score=11 STRING: ENSP00000339007
PECAM1	P16284²^,³	MINT-8033280 MINT-8033310 MINT-8031339 MINT-8033235 MINT-8031324 MINT-8031354 MINT-8033295 I2D: score=3
CCKBR	P32239²^,³, ENSP00000335544⁴	MINT-3381499 MINT-3381756 MINT-8037752 MINT-3381410 MINT-3381872 I2D: score=2 STRING: ENSP00000335544
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-61484 MINT-61492 MINT-61488 MINT-74689 I2D: score=6 STRING: ENSP00000275493

About this table

Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000077	DNA damage checkpoint	IEA	--
GO:0000187	activation of MAPK activity	IEA	--
GO:0006470	protein dephosphorylation	--	--
GO:0006629	lipid metabolic process	--	--
GO:0006641	triglyceride metabolic process	IEA	--

PTPN11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTPN11 for compounds About GeneDecksing

EMD Millipore small molecules for PTPN11:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for PTPN11

Compounds for PTPN11 available from Tocris Bioscience About this table

Compound	Action	CAS #
NSC 87877	Potent inhibitor of shp2 and shp1 PTP	[56990-57-9]

2 HMDB Compounds for PTPN11 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

1 DrugBank Compound for PTPN11 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dodecane-Trimethylamine	--	--	target	--	17139284 17016423 10592235

10/59 Novoseek chemical compound relationships for PTPN11 gene (see all 59) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	89.3	917	9129156 (6), 9582366 (6), 7629070 (6), 19275884 (5) (see all 99)
phosphotyrosine	82	54	12731888 (2), 11684012 (2), 7681217 (1), 8890167 (1) (see all 41)
gp 130	72.8	61	10946280 (4), 12593670 (4), 9285712 (3), 12403768 (3) (see all 26)
phosphatidylinositol	69.5	62	9632795 (3), 8647870 (3), 9565634 (2), 10397152 (2) (see all 45)
phenylalanine	47.8	12	8622663 (1), 8943348 (1), 9756938 (1), 8959326 (1) (see all 10)
phenylarsine oxide	47.7	2	7935386 (1)
inositol	46.3	17	10651806 (1), 11709085 (1), 10623804 (1), 17984366 (1) (see all 16)
ly294002	44.4	2	14762163 (1), 11335710 (1)
sodium orthovanadate	42.6	1	10540326 (1)
echistatin	41.1	5	12399420 (3), 16195423 (1)

Search CenterWatch for drugs/clinical trials and news about PTPN11 / PTN11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTPN11 gene (2 alternative transcripts):

NM_002834.3 NM_080601.1

Unigene Cluster for PTPN11:

Protein tyrosine phosphatase, non-receptor type 11

Hs.506852 [show with all ESTs]

Unigene Representative Sequence: NM_002834

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000531326 ENST00000392597(uc001ttw.1) ENST00000351677(uc001ttx.3)

ENST00000530818

miRNA Products:		OriGene 3'-UTR Clone: PTPN11 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN11
		8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
		hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11 (see all 7) OriGene shRNA RFP: PTPN11 OriGene siRNA: PTPN11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPN11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11

Additional cDNA sequence:

AK289854.1 AK312147.1 BC007869.2 BC008692.1 BC025181.1 BC030949.1 BT007106.1 BX537632.1

D13540.1 EU779706.1 EU779707.1 EU779708.1 L03535.1 L07527.1 L08807.1 S78088.1

U79291.1 X70766.1

18 DOTS entries:

DT.411692 DT.99944225 DT.100733832 DT.91769243 DT.100656212 DT.121153732 DT.95354784 DT.121153765

DT.120647580 DT.70100615 DT.95127024 DT.100783460 DT.121153563 DT.121153748 DT.91871508 DT.92421803

DT.120843678 DT.99974908

24/1484 AceView cDNA sequences (see all 1484):

CR605343 CD049940 BF102663 BG742360 BF365510 BF037064 CB122576 AV712841

BE542112 BE886762 BM550524 AA765096 BG898041 AA341207 BG284893 BI830346

BM794666 CD651903 AA364282 AA313299 BM873857 CB123159 AA382251 BE740256

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTPN11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATGTTGA

About this image
See PTPN11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTPN11

SOURCE GeneReport for Unigene cluster: Hs.506852

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN11:

Multiple Sclerosis in human mouse rat

PI3K-AKT Signaling Pathway in human mouse rat

Protein Phosphatases in human mouse rat

Huntington's Disease in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTPN11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTPN11 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTPN11¹	protein tyrosine phosphatase, non-receptor type 11	85.33(n) 98.31(a)		395815 NM_204968.1 NP_990299.1
lizard (Anolis carolinensis)	Reptilia	PTPN11⁶	--	97(a)	1 ↔ 1	GL343282.1(325780-343622)
African clawed frog (Xenopus laevis)	Amphibia	Xl.936²	Xenopus laevis phosphotyrosyl-protein phosphatase mRNA, more	82.68(n)		U15287.1
zebrafish (Danio rerio)	Actinopterygii	wufi24f03²	wufi24f03	78.16(n)		333979 BC045328.1
fruit fly (Drosophila melanogaster)	Insecta	csw^{1 , 3}	EGF receptor signaling pathway protein tyrosine more³ corkscrew¹	66(a)³ 60.95(n)¹ 66.1(a)¹		45278¹ NM_057782.3¹ NP_477130.1¹
worm (Caenorhabditis elegans)	Secernentea	ptp-2^{1 , 3}	PROTEIN-TYROSINE PHOSPHATASE³ Protein Tyrosine Phosphatase¹	37(a) (best of 3)³ 50.63(n)¹ 44.31(a)¹		II(5918677-5920933)³ 174003¹ NM_062783.4¹ NP_495184.1¹

ENSEMBL Gene Tree for PTPN11 (if available)
TreeFam Gene Tree for PTPN11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTPN11 gene

PTPN7² PTPRH² PTPN22² PTPRO² PTPN6² PTPRJ² PTPRQ² PTPN18²

PTPN12² PTPN5² PTPRB² PTPRR²

18/19 SIMAP similar genes for PTPN11 using alignment to 6 protein entries: PTN11_HUMAN (see all proteins) (see all similar genes):

PTPN6 GRB2 NCK1 GRAP2 VAV3 SHF

RASA1 CLNK CSK VAV1 PIK3R3 SH2B2

HCK SHC4 MATK FYN LCK SYK

PTPN11 for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for PTPN11 (see all 6)
PGOHUM00000244574 PGOHUM00000237709 PGOHUM00000245615 PGOHUM00000235162 PGOHUM00000243393

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28933386^1,2	C,	pathogenic	112915523(+)	`ATGCAA/GATATC`	4	N D	mis¹		1		NA	4550
rs121918457^1,2	C	pathogenic	112926270(+)	`AGGGAC/TGTTCA`	2	T M	mis¹		1		EU	1323
rs121918470^1,2	C	pathogenic	112926909(+)	`AGCACA/C/GGTACC`	3	Q P R	mis¹		0	--	--	--	--
rs61736914^1,2	C,F,	probable-non-pathogenic	112888239(+)	`CATCAC/TGGGCA`	4	H	syn¹		4		NS WA NA	4740
rs184804143^1,2	C,	unknown	112892360(+)	`TTTATA/CTTGAA`	2	--	int¹		0	--	--	--	--
rs121918465^1,2	C	other	112888211(+)	`GGCTGA/C/G/T GTTGG`	8	E A G V	mis¹		0	--	--	--	--
rs7315529^1,2	C,F,H,	--	112854795(+)	`AAAAAA/GTGAGG`	2	--	us2k¹ tfbs³		3		NS NA	408
rs144639620^1,2		--	112855011(+)	`TGTGCA/GCCACC`	2	--	us2k¹		0	--	--	--	--
rs112454444^1,2	C,F,	--	112855348(+)	`CTTCCG/CTACCA`	2	--	us2k¹		3		WA CSA	122
rs12316606^1,2	H	--	112855395(+)	`tttaaG/Aagaca`	2	--	us2k¹		4		NS EA	410

HapMap Linkage Disequilibrium report for PTPN11 (112856155 - 112947717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PTPN11: --
Human Gene Mutation Database (HGMD): PTPN11

5/16 SABiosciences Cancer Mutation PCR Assays for PTPN11 (see all 16):

Cosmic Id	AA Change
13014	p.A72T
13026	p.E76A
13000	p.E76K
13025	p.E76V
13020	p.S502P

5/6 SABiosciences Cancer Mutation PCR Arrays containing PTPN11 (see all 6):

Tyrosine Kinases & Cell Signaling Pathways Panel 384HT

Lymphoid Neoplasms

Hematopoietic Neoplasms

c-MET

Cancer Comprehensive Panel 384HT

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN11

DNA2.0 Custom Variant and Variant Library Synthesis for PTPN11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTPN11 for disorders           About GeneDecksing

OMIM gene information: 176876
OMIM disorders: 163950  151100  607785  156250
UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124

Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:151100]. It is an autosomal

dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic

conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth,

and deafness

Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:163950]. Noonan syndrome (NS) is a

disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor

delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the

jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in

the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with

juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant

Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric

myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and

2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid

progenitors to granulocyte-macrophage colony stimulating factor

Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:156250]. It is a skeletal disorder with

radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple

enchondromas and osteochondroma-like lesions

20/117 diseases for PTPN11 (see all 117): About MalaCards

noonan syndrome cafe-au-lait spots acute myeloid leukemia noonan-like/multiple giant cell lesion syndrome

myeloid leukemia noonan syndrome 1 neurofibromatosis-noonan syndrome leukemia

hydrops fetalis dengue hemorrhagic fever pulmonary valve stenosis hypersensitivity reaction type ii disease

juvenile myelomonocytic leukemia myelomonocytic leukemia patent ductus arteriosus leopard syndrome

hemorrhagic fever developmental disabilities short stature pulmonic stenosis

10 diseases from the University of Copenhagen DISEASES database for PTPN11:

Noonan syndrome LEOPARD syndrome Juvenile myelomonocytic leukemia Pulmonary valve stenosis

Costello syndrome Hypertrophic cardiomyopathy Congenital heart defect Leukemia

Cryptorchidism Gastritis

85 Novoseek disease relationships for PTPN11 gene (see top 10) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
noonan syndrome	96.2	192	17020470 (4), 18348260 (4), 12161469 (4), 15985475 (3) (see all 99)
leopard syndrome	93.4	63	15690106 (4), 16679933 (3), 14991917 (3), 16208280 (2) (see all 38)
juvenile myelomonocytic leukemia	90.3	32	15928039 (2), 15604238 (2), 12717436 (2), 15211660 (2) (see all 26)
cfc syndrome	88.7	10	18651097 (2), 12384786 (2), 12529707 (2), 20052757 (1) (see all 6)
neurofibromatosis-noonan syndrome	82.8	3	17020470 (2), 19449407 (1)
lentigines	79.1	5	19582499 (1), 15470362 (1), 16733669 (1), 18470943 (1) (see all 5)
short stature	77.6	15	15985475 (1), 16498234 (1), 16804314 (1), 20383758 (1) (see all 15)
heart defects congenital	70.3	12	18203203 (3), 16461457 (2), 12960218 (1), 20461756 (1) (see all 9)
pulmonary valve stenosis	66.1	6	11992261 (1), 18678287 (1), 12522798 (1), 17515436 (1) (see all 5)
x-linked lymphoproliferative syndrome	65.1	1	11313386 (1)
developmental disabilities	62.6	12	18223690 (1), 18372317 (1), 15761018 (1), 14974085 (1) (see all 10)
myeloproliferative disorders	59.8	5	15928039 (1), 16939816 (1), 20029231 (1), 16369799 (1)
dengue	55.3	36	10928995 (4), 12436482 (3), 2149144 (2), 1849979 (2) (see all 19)
dengue hemorrhagic fever	55.3	1	12355369 (1)
leukemogenesis	52.5	12	14982869 (2), 14644997 (2), 17003374 (1), 18927438 (1) (see all 10)
cherubism	51.5	2	17120035 (1), 15996221 (1)
leukemia	50.5	47	16030196 (4), 15834506 (4), 19874312 (2), 12826400 (1) (see all 28)
influenza	49	97	1824958 (6), 12149435 (5), 19403682 (4), 8764047 (3) (see all 43)
conduction abnormalities	48.4	2	16208280 (1), 18470943 (1)
deafness sensorineural	44.7	1	18470943 (1)
somatic mutations	44.2	18	12717436 (2), 15561680 (1), 15928039 (1), 16518851 (1) (see all 15)
neurofibromatosis type 1	43.6	4	19047918 (2), 15087069 (1), 16523510 (1)
flavivirus infections	40.8	3	15617345 (1), 17319166 (1)
lymphoproliferative syndrome	37.6	1	11313386 (1)
leukemia myelomonocytic chronic	36.2	1	15725481 (1)
mental retardation	33.8	1	20399956 (1)
myelodysplastic syndromes	31	7	12717436 (2), 18089853 (1), 15725481 (1), 15282682 (1) (see all 6)
aml childhood	29.2	2	15385933 (1), 15842656 (1)
virus infection	28.2	14	12149435 (2), 10388664 (2), 17596305 (1), 12355369 (1) (see all 8)
parvovirus infections	28	3	11907229 (2), 11992589 (1)
solid tumor	27.5	16	18223690 (3), 16631468 (2), 16518851 (1), 17053061 (1) (see all 8)
lymphoblastic leukemia acute childhood	26.7	5	17910045 (2), 16533526 (1), 19776760 (1), 14982869 (1)
hematologic malignancies	26.1	11	16518851 (3), 15385933 (1), 15725481 (1), 17177198 (1) (see all 8)
neurofibromatosis	22.8	2	19798502 (1), 20008299 (1), 17353900 (1)
cafe-au-lait spots	21	1	12161596 (1)
lymphoblastic leukemia acute	20.5	6	15604238 (2), 17361219 (1), 16533526 (1), 16299723 (1) (see all 5)
rhabdomyosarcoma	18.3	2	16518851 (2)
cancer	17.9	39	15385933 (2), 15604238 (2), 17647198 (1), 9693956 (1) (see all 24)
hydrops fetalis	17.7	2	15211660 (2)
genetic disorder	17.5	3	15987685 (1), 18064648 (1)
aml adult	16.6	1	15604238 (1)
encephalitis japanese	15.8	1	9130232 (1)
gastritis atrophic	15.2	3	12925139 (2), 12552462 (1)
cardiomyopathy	14.6	3	15001945 (2), 15937948 (1)
myeloid leukemia	12.7	2	18192401 (1), 17942397 (1)
congenital heart disease	9.42	4	15940693 (3), 17413276 (1)
lymphoma t-cell	9.41	2	12543077 (2)
gastritis	8.97	1	17724739 (1)
gastric cancer	8.66	9	17724739 (1), 17568183 (1), 19589142 (1), 14699500 (1) (see all 5)
myeloid leukemia chronic	8.19	2	16255985 (1), 16278304 (1)
glioblastoma	7.22	5	11593409 (1), 19427850 (1), 10962556 (1), 14701753 (1)
mimicry	5.02	3	15611263 (1), 19822367 (1), 18679379 (1)
carcinoma	4.93	2	17924469 (1), 8959326 (1)
tumors	4.75	29	15604238 (2), 11340297 (2), 10864922 (1), 15827150 (1) (see all 22)
lupus erythematosus systemic	4.64	1	12847688 (1)
heart failure	3.71	1	19001090 (1)
metastasis	3.23	4	18643929 (2), 10435080 (1), 18482983 (1)
rheumatoid arthritis	2.74	3	8970971 (1), 15383603 (1)
prostate cancer	1.23	4	16181551 (3), 16352563 (1)
bleeding	0.952	2	12161469 (1)
cardiomyopathy hypertrophic obstructive	0.831	2	16733669 (1), 17116277 (1)
breast carcinoma	0	1	17537730 (1)
autoimmune diseases	0	2	16542377 (1), 11992589 (1)
response acute phase	0	1	10661409 (1)
heart diseases	0	3	19541608 (1), 16461457 (1)
atrophy	0	11	18712962 (2), 19589142 (1), 17211494 (1)
colon cancer	0	1	16082388 (1)
metaplasia	0	1	17724739 (1)
burkitt lymphoma	0	2	10382761 (1)
acute leukemia	0	3	14982869 (1), 18328949 (1), 16956752 (1)
insulin sensitivity	0	1	17185494 (1)
inflammation	0	6	17647198 (2), 19665497 (1), 12947019 (1), 20157547 (1)
glioma	0	4	11223155 (1), 7588774 (1), 16631468 (1), 19936768 (1)
breast cancer	0	23	18643929 (7), 18421299 (5), 19261604 (2), 12060651 (1) (see all 8)
arthritis	0	3	9783684 (1), 15383603 (1)
infection chronic	0	1	10395869 (1)
lymphoma	0	5	17483340 (2), 18192401 (1), 12531430 (1), 19798502 (1)
obesity	0	2	16441233 (2)
hepatitis c	0	1	12824191 (1)
melanoma	0	3	17927788 (1), 19209145 (1), 19836376 (1)
hyperplasia	0	1	17924469 (1)
congenital malformation	0	2	20308328 (1), 16399795 (1)
effusion	0	2	16032767 (1), 17414570 (1)
immunodeficiency	0	2	16162482 (1), 11533153 (1)
rheumatic diseases	0	3	12847688 (1), 12794831 (1)

GeneTests: PTPN11

LEOPARD Syndrome

Noonan Syndrome

Genetic Association Database (GAD): PTPN11
Human Genome Epidemiology (HuGE) Navigator: PTPN11 (48 documents)

Export disorders for PTPN11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PTPN11 gene, integrated from 9 sources (see all 1200):
(articles sorted by number of sources associating them with PTPN11)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. (PubMed id 1280823)^{1, 2, 3, 9} Freeman R.M....Neel B.G. (1992)
PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype- phenotype correlation, and phenotypic heterogeneity. (PubMed id 11992261)^{1, 2, 4, 9} Tartaglia M.... Gelb B.D. (2002)
PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) mutations and response to growth hormone therapy in children with Noonan syndrome. (PubMed id 15956085)^{1, 4, 9} Ferreira L.V....Jorge A.A. (2005)
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP 2). (PubMed id 20170098)^{1, 2, 9} Zhang X....Zhang Z.Y. (2010)
PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. (PubMed id 19020799)^{1, 2, 9} Ko J.M....Yoo H.W. (2008)
Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11. (PubMed id 15690106)^{1, 2, 9} Kalidas K.... Jeffery S. (2005)
Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive). (PubMed id 16679933)^{1, 2, 9} Ucar C.... Heinritz W. (2006)
Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). (PubMed id 11433379)^{1, 2, 9} Pfrepper K.-I.... Schraven B. (2001)
Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. (PubMed id 18829466)^{1, 2, 9} Jakob S.... Haendeler J. (2008)
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (PubMed id 15928039)^{1, 4, 9} Kratz C.P....Loh M.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5781	HGNC: 9644	AceView: RPL6	Ensembl:ENSG00000179295	euGenes: HUgn5781
ECgene: PTPN11	Kegg: 5781	H-InvDB: PTPN11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PTPN11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PTPN11	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PTPN11

Intellectual Property for PTPN11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PTPN11 gene:
Search GeneIP for patents involving PTPN11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore small molecules (inhibitor) for PTPN11
	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
	EMD Millipore Purified and/or Recombinant PTPN11 Protein

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for PTPN11 (SHP-2)		Browse Cell Culture Products
	ELISAs for PTPN11 (SHP-2)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Kinase Activity Assays/Reagents for PTPN11 (SHP-2)
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for PTPN11 (SHP-2)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for PTPN11 (SHP-2)

	OriGene Antibodies for PTPN11		OriGene shRNA RFP for PTPN11
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PTPN11		OriGene 3'-UTR Clone for PTPN11
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for PTPN11		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PTPN11		OriGene Custom Protein Services for PTPN11
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTPN11
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN11
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN11
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11

	GenScript Custom Purified and Recombinant Proteins Services for PTPN11		GenScript cDNA clones with any tag delivered in your preferred vector for PTPN11
	GenScript Custom Assay Services for PTPN11		GenScript Custom Superior Antibodies Services for PTPN11
	GenScript Custom overexpressing Cell Line Services for PTPN11		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for PTPN11 (SHP-2)

	Regulatory tfbs in PTPN11 promoter
	Search Chromatin IP Primers for PTPN11
	RT² qPCR Primer Assay in human, mouse, rat PTPN11
	GNC Network for PTPN11
	SABiosciences PCR Arrays including human, mouse, rat PTPN11

Tocris compounds for PTPN11

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs/Proteins for PTPN11
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PTPN11 antibodies
	PTPN11 proteins
	PTPN11 lysates

	Antibodies for PTPN11
	See all of Abcam's Antibodies, Kits and Proteins for PTPN11
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

PTPN11 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for PTPN11

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

	Browse SwitchGear 3'UTR luciferase reporter plasmids for PTPN11
	SwitchGear Promoter luciferase reporter plasmids for PTPN11

ThermoFisher Antibodies for PTPN11

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PTPN11 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

PTPN11 Gene

protein tyrosine phosphatase, non-receptor type 11

Aliases
for PTPN11 gene

Summaries
for PTPN11 gene

Genomic Views
for PTPN11 gene

Proteins
for PTPN11 gene

Protein Domains /
Families
for PTPN11 gene

Function
for PTPN11 gene

Pathways & Interactions
for PTPN11 gene

Drugs & Compounds
for PTPN11 gene

Transcripts
for PTPN11 gene

Expression
for PTPN11 gene

Orthologs
for PTPN11 gene

Paralogs
for PTPN11 gene

Genomic Variants
for PTPN11 gene

Disorders / Diseases
for PTPN11 gene

Publications
for PTPN11 gene

External Searches for PTPN11 gene

Genome Databases showing PTPN11 gene

Other Databases showing PTPN11 gene

Specialized Databases showing PTPN11 gene

Intellectual Property
for PTPN11 gene

Products
for PTPN11 gene

View Random Gene

Lymphoblastic Leukemia Acute Childhood
Conduction Abnormalities
Leukemia Myelomonocytic Chronic
Lymphoma T-Cell
Hydrops Fetalis
insulin sensitivity
Breast Cancer
Metaplasia
Cardiomyopathy Hypertrophic Obstructive
X-Linked Lymphoproliferative Syndrome
CFC SYNDROME
Rheumatic Diseases
CONGENITAL HEART DISEASE
Cancer
Rhabdomyosarcoma
somatic mutations
Lymphoma
Cardiomyopathy
Heart Defects Congenital
Cherubism
Myeloproliferative Disorders
effusion
Deafness Sensorineural
Inflammation
Burkitt Lymphoma
Noonan Syndrome
SHORT STATURE
immunodeficiency
Cafe-au-Lait Spots
Rheumatoid Arthritis
prostate cancer
Neurofibromatosis Type 1
Mental Retardation
Tumors
Metastasis
Lymphoblastic Leukemia Acute
Encephalitis Japanese
mimicry
Glioblastoma
virus infection
Parvovirus Infections
Hepatitis C
JUVENILE MYELOMONOCYTIC LEUKEMIA
Developmental Disabilities
Gastric Cancer
Gastritis Atrophic
Myeloid Leukemia
Melanoma
BREAST CARCINOMA
Autoimmune Diseases
Colon Cancer
Pulmonary Valve Stenosis
Dengue Hemorrhagic Fever
Hyperplasia
Glioma
Flavivirus Infections
LEOPARD Syndrome
Carcinoma
ACUTE LEUKEMIA
Leukemia
Myeloid Leukemia Chronic
NEUROFIBROMATOSIS-NOONAN SYNDROME
congenital malformation
AML adult
Neurofibromatosis
Hematologic Malignancies
HEART FAILURE
Influenza
Heart Diseases
Response Acute Phase
LENTIGINES
Bleeding
Dengue
OBESITY
solid tumor
Gastritis
AML childhood
Atrophy
Infection chronic
leukemogenesis
genetic disorder
LYMPHOPROLIFERATIVE SYNDROME
Myelodysplastic Syndromes
Lupus Erythematosus Systemic
Arthritis

Advanced Search

Export list of displayed genes

PTPN11 Gene

protein tyrosine phosphatase, non-receptor type 11

Aliasesfor PTPN11 gene

Summariesfor PTPN11 gene

Genomic Viewsfor PTPN11 gene

Proteinsfor PTPN11 gene

Protein Domains /Familiesfor PTPN11 gene

Functionfor PTPN11 gene

Pathways & Interactionsfor PTPN11 gene

Drugs & Compoundsfor PTPN11 gene

Transcriptsfor PTPN11 gene

Expression for PTPN11 gene

Orthologsfor PTPN11 gene

Paralogsfor PTPN11 gene

Genomic Variantsfor PTPN11 gene

Disorders / Diseasesfor PTPN11 gene

Publicationsfor PTPN11 gene

External Searches for PTPN11 gene

Genome Databases showing PTPN11 gene

Other Databases showing PTPN11 gene

Specialized Databases showing PTPN11 gene

Intellectual Propertyfor PTPN11 gene

Productsfor PTPN11 gene

View Random Gene

Aliases
for PTPN11 gene

Summaries
for PTPN11 gene

Genomic Views
for PTPN11 gene

Proteins
for PTPN11 gene

Protein Domains /
Families
for PTPN11 gene

Function
for PTPN11 gene

Pathways & Interactions
for PTPN11 gene

Drugs & Compounds
for PTPN11 gene

Transcripts
for PTPN11 gene

Expression
for PTPN11 gene

Orthologs
for PTPN11 gene

Paralogs
for PTPN11 gene

Genomic Variants
for PTPN11 gene

Disorders / Diseases
for PTPN11 gene

Publications
for PTPN11 gene

Intellectual Property
for PTPN11 gene

Products
for PTPN11 gene