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PTPN11 Gene

protein-coding   GIFtS: 76
GCID: GC12P112856

Protein Tyrosine Phosphatase, Non-Receptor Type 11

(Previous name: Noonan syndrome 1)
(Previous symbol: NS1)
  See PTPN11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 111 2     EC 3.1.3.483 8
NS11 2 5     SHP22 5
PTP2C2 3 5     Noonan Syndrome 11
Protein-Tyrosine Phosphatase 1D2 3     BPTP32
Protein-Tyrosine Phosphatase 2C2 3     CFC2
PTP-1D2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 112
PTP-2C2 3     SHP-23
SH-PTP22 3     SHPTP23
SH-PTP32 3     Shp23

External Ids:    HGNC: 96441   Entrez Gene: 57812   Ensembl: ENSG000001792957   OMIM: 1768765   UniProtKB: Q061243   

Export aliases for PTPN11 gene to outside databases

Previous GC identifers: GC12P111712 GC12P112333 GC12P112639 GC12P111268 GC12P111319 GC12P109868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTPN11 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function
as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is
widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important
for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and
cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for PTPN11 Gene:
PTPN11 (protein tyrosine phosphatase, non-receptor type 11) is a protein-coding gene. Diseases associated with PTPN11 include ptpn11-related noonan syndrome, and ptpn11-related leopard syndrome. GO annotations related to this gene include SH3/SH2 adaptor activity and protein domain specific binding. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the
signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in
stimulatation of its RhoA binding activity

summary for PTPN11 Gene:
Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups
from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of
kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs
are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.
PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity
phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.
MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been
implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator
of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In
cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPN11 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN11 promoter sequence
   Search Chromatin IP Primers for PTPN11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.1

PTPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112856:  view genomic region     (about GC identifiers)

Start:
112,856,155 bp from pter      End:
112,947,717 bp from pter
Size:
91,563 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 11  
Size: 597 amino acids; 68436 Da
Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity).
Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3
(tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine
phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts
with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and
ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT;
the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated);
participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11
phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11
phosphatase activity. Interacts with GAREM isoform 1 (tyrosine phosphorylated); the interaction increases
MAPK/ERK activity and does not affect the GRB2/SOS complex formation
Selected PDB 3D structures from and Proteopedia for PTPN11 (see all 13):
2SHP (3D)        3B7O (3D)        3MOW (3D)        3O5X (3D)        3TKZ (3D)        3TL0 (3D)    
Secondary accessions: A8K1D9 Q96HD7
Alternative splicing: 3 isoforms:  Q06124-1   Q06124-2   Q06124-3   

Explore the universe of human proteins at neXtProt for PTPN11: NX_Q06124

Explore proteomics data for PTPN11 at MOPED

Post-translational modifications: 

  • Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding
    site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3.
    Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated
    PDGFRB1
  • Ubiquitination2 at Lys594
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTPN11 (Q06124) (see all 20)
     WPDHGVP  SRRWFHP  DPTSERW  VVHCSAG 


    See PTPN11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002825.3  NP_542168.1  

    ENSEMBL proteins: 
     ENSP00000376376   ENSP00000340944   ENSP00000437013  
    Reactome Protein details: Q06124

    PTPN11 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PTPN11 Protein
    R&D Systems Recombinant & Natural Proteins for PTPN11 (SHP-2)
    Enzo Life Sciences proteins for PTPN11
    OriGene Purified Protein for PTPN11
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for PTPN11
    OriGene Custom Protein Services for PTPN11
    GenScript Custom Purified and Recombinant Proteins Services for PTPN11
    Novus Biologicals PTPN11 Proteins
    Novus Biologicals PTPN11 Lysates
    Sino Biological Recombinant Protein for PTPN11
    Sino Biological Cell Lysate for PTPN11
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN11

     
    Search eBioscience for Proteins for PTPN11 

     
    antibodies-online proteins for PTPN11 (8 products) 

     
    antibodies-online peptides for PTPN11

    PTPN11 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
    R&D Systems Antibodies for PTPN11 (SHP-2)
    Cell Signaling Technology (CST) Antibodies for PTPN11  (SHP-2)
    OriGene Antibodies for PTPN11
    OriGene Custom Antibody Services for PTPN11
    Novus Biologicals PTPN11 Antibodies
    Abcam antibodies for PTPN11
    Cloud-Clone Corp. Antibodies for PTPN11
    ThermoFisher Antibody for PTPN11
    antibodies-online antibodies for PTPN11 (289 products) 

    PTPN11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTPN11
    R&D Systems ELISAs for PTPN11 (SHP-2)         (see all)
    GenScript Custom Assay Services for PTPN11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPN11
    Cloud-Clone Corp. CLIAs for PTPN11
    Search eBioscience for ELISAs for PTPN11 
    antibodies-online kits for PTPN11 (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR000980 SH2
     IPR012152 Tyr_Pase_non-rcpt_typ-6/11

    Graphical View of Domain Structure for InterPro Entry Q06124

    ProtoNet protein and cluster: Q06124

    2 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000980 SH2 domain signature


    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Domain: The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing
    proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPN11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN11_HUMAN, Q06124
    Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the
    signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in
    stimulatation of its RhoA binding activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN11:
    protein tyrosine phosphatase,non receptor type 11,with two SH2 domains,expressed in heart,brain,skeletal muscle
    with homology to Drosophila corkscrew,involved in intracellular signal transduction in response to
    PDGF,EGF,insulin,interacting with protein zero related (PZR) for cell signaling,overexpressed in neutrophils
    cells from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in
    signaling pathways)

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IDA15133037
    GO:0004725protein tyrosine phosphatase activity TAS--
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity TAS--
    GO:0005070SH3/SH2 adaptor activity IDA7493946
    GO:0005158insulin receptor binding IPI7493946
         
    Find genes that share ontologies with PTPN11           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPN11:
     Decreased focal adhesion (FA)   Increased cell death in breast  Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Ptpn11) (see all 26):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with PTPN11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPN11: Ptpn11tm1Rbn Ptpn11tm2Bgn Ptpn11tm1.2Cbm Ptpn11tm1Paw

       genOway: Develop your customized and physiologically relevant rodent model for PTPN11

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPN11:
    hsa-mir-23a-3p (MIRT007150), hsa-mir-489-3p (MIRT003549), hsa-mir-183-5p (MIRT047153), hsa-mir-320a (MIRT044548), hsa-mir-130b-5p (MIRT038301), hsa-mir-181a-5p (MIRT006482), hsa-mir-124-3p (MIRT022573), hsa-mir-218-5p (MIRT024234), hsa-mir-193b-3p (MIRT041308)

    Block miRNA regulation of human, mouse, rat PTPN11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PTPN11
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPN11

    Clone
    Products:
         
    OriGene clones in human, mouse for PTPN11 (see all 7)
    OriGene ORF clones in mouse, rat for PTPN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    Sino Biological Human cDNA Clone for PTPN11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11
    Addgene plasmids for PTPN11 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTN11_HUMAN, Q06124: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton3
    plasma membrane3
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15133037
    GO:0005737cytoplasm IDA10940933
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0043234protein complex IEA--

    Find genes that share ontologies with PTPN11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPN11 About   (see all 89)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Neurotrophin signaling pathway0.36
    2FGFR ligand binding and activation
    FRS2-mediated cascade0.70
    Development FGF family signaling0.43
    Negative regulation of FGFR signaling0.56
    Spry regulation of FGF signaling0.00
    3Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    4Translation Insulin regulation of translation
    Development CNTF receptor signaling0.43
    ErbB2/ErbB3 signaling events0.31
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39


    Find genes that share SuperPaths with PTPN11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for PTPN11
        Adipocytokines & Insulin Signaling
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTPN11
        Epithelial Adherens Junctions

    3 Cell Signaling Technology (CST) Pathways for PTPN11
        Phosphatases
    MAP Kinase Signaling
    Apoptosis and Autophagy

    Selected GeneGo (Thomson Reuters) Pathways for PTPN11 (see all 24)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development FGF-family signaling
    Development CNTF receptor signaling
    Development Thrombopoetin signaling via JAK-STAT pathway
    Chemotaxis CXCR4 signaling pathway

    Selected BioSystems Pathways for PTPN11 (see all 47)
        Heart Development
    EGFR1 Signaling Pathway
    Insulin Signaling
    Type II interferon signaling (IFNG)
    Oncostatin M Signaling Pathway


    Selected Reactome Pathways for PTPN11 (see all 26)
        Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Costimulation by the CD28 family
    Prolactin receptor signaling
    FRS2-mediated cascade


    Selected Kegg Pathways  (Kegg details for PTPN11) (see all 11):
        Ras signaling pathway
    Jak-STAT signaling pathway
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    Neurotrophin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTPN11: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Huntington's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTPN11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTPN11 (Q061241, 2, 3 ENSP000003409444) via UniProtKB, MINT, STRING, and/or I2D (see all 399)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234078Q083451, 2, 3, ENSP000004013974EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 STRING: ENSP00000401397
    ENSG00000137332Q083451, 2, 3EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 
    ENSG00000215522Q083451, 2, 3EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 
    ENSG00000230456Q083451, 2, 3EBI-297779,EBI-711879 MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 
    GAB1Q134801, 2, 3, ENSP000002629954EBI-297779,EBI-517684 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000262995
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IEA--
    GO:0000187activation of MAPK activity IEA--
    GO:0006470protein dephosphorylation ----
    GO:0006629lipid metabolic process ----
    GO:0006641triglyceride metabolic process IEA--

    Find genes that share ontologies with PTPN11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PTPN11
      Browse compounds at ApexBio 

    Compounds for PTPN11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Alexidine dihydrochlorideSelective inhibitor of PTPMT1[1715-30-6]
    Sodium orthovanadateProtein tyrosine phosphatase inhibitor[13721-39-6]
    TCS 401Selective inhibitor of PTP1B[243967-42-2]
    BVT 948Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling[39674-97-0]
    NSC 87877Potent inhibitor of shp2 and shp1 PTP[56990-57-9]

    2 HMDB Compounds for PTPN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PTPN11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dodecane-Trimethylamine-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for PTPN11 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.3 917 9129156 (6), 9582366 (6), 7629070 (6), 19275884 (5) (see all 99)
    phosphotyrosine 82 54 12731888 (2), 11684012 (2), 7681217 (1), 8890167 (1) (see all 41)
    gp 130 72.8 61 10946280 (4), 12593670 (4), 9285712 (3), 12403768 (3) (see all 26)
    phosphatidylinositol 69.5 62 9632795 (3), 8647870 (3), 9565634 (2), 10397152 (2) (see all 45)
    phenylalanine 47.8 12 8622663 (1), 8943348 (1), 9756938 (1), 8959326 (1) (see all 10)
    phenylarsine oxide 47.7 2 7935386 (1)
    inositol 46.3 17 10651806 (1), 11709085 (1), 10623804 (1), 17984366 (1) (see all 16)
    ly294002 44.4 2 14762163 (1), 11335710 (1)
    sodium orthovanadate 42.6 1 10540326 (1)
    echistatin 41.1 5 12399420 (3), 16195423 (1)



    Find genes that share compounds with PTPN11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PTPN11 gene (2 alternative transcripts): 
    NM_002834.3  NM_080601.1  

    Unigene Cluster for PTPN11:

    Protein tyrosine phosphatase, non-receptor type 11
    Hs.506852  [show with all ESTs]
    Unigene Representative Sequence: NM_002834
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531326 ENST00000392597(uc001ttw.1) ENST00000351677(uc001ttx.3)
    ENST00000530818
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTPN11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTPN11
    Predesigned siRNA for gene silencing in human, mouse, rat PTPN11
    Clone
    Products:
         
    OriGene clones in human, mouse for PTPN11 (see all 7)
    OriGene ORF clones in mouse, rat for PTPN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11
    Addgene plasmids for PTPN11 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTPN11
      QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
      QuantiFast Probe-based Assays in human, mouse, rat PTPN11

    Additional mRNA sequence: 

    AK289854.1 AK312147.1 BC007869.2 BC008692.1 BC025181.1 BC030949.1 BT007106.1 BX537632.1 
    D13540.1 EU779706.1 EU779707.1 EU779708.1 L03535.1 L07527.1 L08807.1 S78088.1 
    U79291.1 X70766.1 

    18 DOTS entries:

    DT.411692  DT.99944225  DT.91769243  DT.100733832  DT.100656212  DT.121153732  DT.95354784  DT.121153765 
    DT.120647580  DT.70100615  DT.95127024  DT.100783460  DT.121153563  DT.121153748  DT.91871508  DT.92421803 
    DT.120843678  DT.99974908 

    1484 AceView cDNA sequences (see top 24):

    BG898041 BU526614 AW405946 AI967970 F27501 AA374206 CF128365 BX114871 
    BI227225 CR603976 AA307193 BM705443 BM473884 AA360905 BE394537 CR599701 
    BU185398 BE383217 CB149157 AA644222 BF589532 CA941003 BE888230 BM802399 
    BE542112 BM466516 W60378 C05221 BG178854 BI439081 AA314302 AA306182 
    BU079092 BQ071929 BM696283 CB131938 BE792341 AA321644 AA360934 BE897317 
    BE778575 BI545879 BC071912 AW405713 AA360833 BI829477 BM798157 AL523602 
    BQ677828 BE278721 BE409026 BQ417364 BU662058 BQ027469 BQ214666 BU790436 
    BG109087 CB135576 CF128216 BE206492 AA975177 AA355554 CK430262 BM821286 
    CB115027 AA313764 CR605631 BI497103 CB153901 W60287 BU665153 BE512842 
    BE018336 BE886762 CR625620 BE267900 BU785250 BE257908 BC004138 BG110137 
    AA765096 BE783434 BC013863 AA364282 BQ787748 CB116796 BM794666 BX951572 
    BQ214278 BG504448 BU164316 CB120507 CB123159 BE797081 BU509143 BP430232 
    BI830346 AA167295 BE779232 BG742360 BM873857 BG284893 BF792187 BU160895 
    BI223825 CR605343 CR623025 AA313712 AV706576 CF126191 CD651903 CR605132 
    BU528497 CB122576 CR610998 BM798036 CR612863 BG499282 CR622401 BM454943 
    BM846323 BE877108 CR624575 AW407761 CR610164 BM829804 BQ648096 CD676521 
    AI097230 BQ683339 AA328180 BE909561 BE296681 BU074678 BQ688395 CB122615 
    CB124529 AA313242 BI335801 BG289282 BI913380 BE872857 AV708487 BU078966 
    CR608788 BG110389 BU166358 CR618245 CA950580 BE740256 AA341207 BF037064 
    CA441817 BG035085 BE880113 CD049940 BE383019 BE278100 CA772394 BQ214477 
    BE790807 AV712841 CB147739 BE731235 BF797358 CB136218 BM700074 AA306101 
    BM800739 AI718939 AA315537 BE782180 AA329690 BE378172 BI438493 AA328009 
    BQ632734 BE884819 BM854650 BE560749 CF128094 BF365510 AW405347 BG285724 
    BM471972 CB132341 NM_000970 BM888421 AW407086 AW406003 D12002 F29250 
    AA313299 BM550524 BU196052 AW238895 BE537402 AA374122 AA311815 BE894877 
    BG109884 BE266156 BM749129 AV654428 CR595147 AI867523 BM466459 AA377277 
    CA777112 AA308575 AA312165 AA313900 AA300950 AA315486 BF102663 AW059516 
    CB140996 BE268077 BQ605334 BG109947 CB132331 AI924245 BE783660 BG109306 
    AA326335 CB132371 CF126978 AW366764 AA382251 CR595727 BM914982 AA352866 
    CF128104 CB069545 BM749172 BP378685 BE799827 BM051474 BV174637 BF037814 
    CF128487 BG121895 BU171500 BG328704 CB114932 CF130806 AW405919 CA942096 
    CB123044 BQ222922 CD048641 BM559143 BG744161 BG685750 AV726598 BE269842 
    BF349958 BE619090 CN482690 BF305761 BE873726 CA947030 BE892127 F24104 
    CF134649 AW328321 BE397569 BG392119 BG397262 BG759457 BG684743 BE547810 
    BU615290 BE545458 BM552223 BF184353 BM271922 BU170605 BG655039 AA953173 
    CB131964 AA359759 BF968762 BF794997 AA879167 BQ272056 BG759315 CB135032 
    BG033571 AW404881 BE314109 BE786596 BE379330 BG496348 CB267844 BM353714 
    BG342106 BQ690785 BI225572 BE409024 BI861641 AW406101 BE410512 BQ213521 
    AW245902 CD050419 BU517025 CF131102 BU790403 N44620 CB069043 CN481838 
    BG032426 BG825883 BI116289 BM798447 BF972602 BI222229 BM457904 BE786822 
    AF261087 BQ631925 BE408857 BF974485 BM015895 BE266346 BG661276 BE538412 
    BE379915 AA336355 AJ705797 BE782230 BE548208 CA950080 AA311713 CA849113 
    AA316528 BE897652 AW515656 BF203203 AJ711805 BE560319 CA405655 CD513919 
    BE874936 BF672617 BF870358 BQ777051 BG327165 BG566899 BC022444 BF305227 
    CD386670 BI194978 CB115088 AA316342 CA435106 BG179840 BG531178 BP375694 
    BE542384 BF796788 BQ440877 BU951095 BE394053 CA773715 AA373697 BE875921 
    BM312750 BE546609 BG821345 BQ270084 BE780095 AW405416 BX373119 BE783805 
    AV707604 BG113260 BI258314 AW406734 BP372765 CK126115 AA373912 CA337323 
    CD049618 BI226089 BE881788 BG746461 AA375115 T39807 CB144127 BE783854 
    BX410405 BG179583 BM469970 BG743142 CA453836 BG396281 BM457681 BE727726 
    F35500 BE787587 BE799027 BG827165 BE566683 BE392802 BG033781 BI334116 
    BE786555 BG821483 AA007561 BU076484 AW452748 BG529652 AA953541 BG686414 
    BF797677 AJ706945 AJ712438 BU074733 BI763374 BE383207 BE798716 BI858114 
    BE048108 BC020679 BM710695 BG757564 BE257867 BI086643 BG330957 AW406130 
    BE612821 AA360021 AA314963 BE910090 AW859802 BM510391 AW327711 BG753365 
    D17554 AA364348 BE889549 CD243038 BF036908 BM051534 BE866166 BP871435 
    CF128511 BG396863 BE884646 BM799251 BG534458 BC070195 CA772762 BU072858 
    AA180533 BF036230 BI911539 BF974044 BX476536 BE799725 AA131296 BQ776400 
    AA626531 BE278207 CN484975 CA942436 AA385584 BG327434 BI197252 CB118534 
    BU175684 BF305233 BE880286 AA328827 F32690 BU951535 BQ066063 AW850395 
    BG032870 AA720797 AA827416 D55733 BG390667 BQ083113 BG825415 BU594965 
    BM010255 AW406286 CB116565 BF032905 BG339900 BE409740 AV763841 AA366632 
    AW404624 BE394728 CF454440 AW409732 AA313672 BG324273 BQ227694 BX434329 
    AW956100 BM794256 BG250054 AA374911 BG489824 BG828401 BF037566 BX403939 
    AA773454 BI227286 BI855778 AA330229 BF026726 BM017702 BI856147 BQ652577 
    BE788580 BE254404 BE783746 BM789377 D55806 BG291055 BE613484 CF126746 
    BG116071 BI226799 CF131125 BM745833 BG768286 BF973365 BG285962 BG760941 
    BM083559 BG473547 CD640506 BE616728 BU179955 BE256130 BE388310 AA661671 
    BM353045 BG655015 BF308065 BG341756 BG753155 BQ884193 BF125785 BE879149 
    BE560855 S71022 CB115765 BG332421 BE540661 AA370411 BG678040 AA361594 
    BE275519 BE265938 N83298 BM314709 CF131147 AA372767 BM905021 BE910405 
    BU951179 BG685238 BQ581452 BI857774 BI087195 BG773327 BE898208 BE254278 
    BG167369 CF126572 BQ269461 BU074751 BG828861 BQ233479 BM511067 CF126778 
    BQ065805 BG392830 BG256274 BE172530 BM051472 BI712616 BG334021 BP367958 
    AA340158 CF127097 AA485899 BE560923 CA405502 BE872964 BQ948122 BG490978 
    BE790565 AI831221 BE866597 D31005 BQ424164 AA955008 BM046195 BU193338 
    CD639017 CB134120 BE795180 BE788168 AW880578 BU172275 BU170410 BE880474 
    BX476441 BI713768 BM753856 BF984247 AA303669 BI226467 BG756426 AI955638 
    BE786029 BE780732 AA128649 BX410404 AV724384 BE744329 AA314831 BG342071 
    AV657723 BG821328 AV713873 CB070137 BE252000 AJ707260 BM457428 BM795582 
    BM843972 BG256623 BE905513 AW327349 BG779138 BE928662 BF797646 BI091217 
    CB121046 BM819165 AA316262 BG394227 BF103886 BG282131 BQ882846 BI090458 
    AW956502 AV714856 BM838583 AA115154 BI223512 AW406433 BE880805 BF205126 
    BC032299 AA329849 BG030131 AW577511 AA312509 BE728217 BM263517 CF127435 
    AA774837 CK004108 BF574432 AA330370 BI086574 BE568097 BG481192 BG756377 
    BE070294 CB149115 BX385707 BM312511 BE791389 AA364721 AV751759 BG165289 
    BE879868 BQ942715 CB268161 BG397661 AA373978 AW455209 BM852324 BG826562 
    BF036669 BG773571 AA298857 BG757239 D55297 BG397420 AW162904 BF315077 
    CB135402 AV705768 D57284 BF305275 BM016899 BG030209 AA582279 CA413318 
    BF344108 AA296217 BG767696 T57948 BG111681 BE395513 CD386139 BU581622 
    BI117567 BE299740 BG336221 BQ652083 BE794423 AA352996 BE293637 AW880571 
    BE392189 BX432532 BI195958 BQ424450 BG109318 AA314797 BE267768 BU509890 
    BG397598 BQ220065 AL703668 BE279975 AA307591 BM697998 BG252635 BF338612 
    BG685720 BU602509 AW407040 BI869580 CA867618 AA379418 AI247302 AA296470 
    BI825198 CD514153 AI744924 D55962 CD247402 BM852776 BX410406 CF128219 
    BM509297 AW407455 CB134435 CB144877 BG826734 BE151939 BU664970 BM854690 
    BI091631 BG697466 BG825332 AW404503 BP347885 AA364088 BE618985 BX378566 
    AJ710683 BE783225 AA312972 BF036476 BE564659 BE258515 AV727931 AA373817 
    AW954712 BG927443 BE782689 BG987584 BG386023 AA360343 BE790626 BG260116 
    BX345734 BM049229 AW407022 AW366761 BF308875 CA843359 BM051349 CD697839 
    BG756451 AW675430 BQ421574 BU078205 BI114431 N22493 BE567867 BQ777388 
    AW406954 BF663714 AW407055 BC031009 AW404887 BF973139 AJ711722 BU196503 
    BI193826 BG166380 CA436162 BU580830 X69391 AA343157 BQ286309 BU954243 
    AV751995 CA841963 BE263638 R57773 AA379363 AA468374 CB146899 BE871738 
    BF175600 CB135157 AA310597 BE960619 AW601923 C03293 T72271 D57217 
    BE865632 AA074808 AA130983 BI093036 BU533638 AA358229 AA384292 W39545 
    BG897057 AI654390 AA970586 BF082874 AA342140 BE298116 BG527675 BE541000 
    BU194640 AA330383 D55513 BE792316 BG714539 AA379220 BF310936 CA777568 
    BE871848 CF140202 BE619455 AW850366 CD250805 AA188440 BQ878702 AW954651 
    BE960887 BI856192 BE268327 BQ060090 AW404969 AW390392 BP375692 BU169449 
    AA167296 BE560282 BM313114 BM755144 AA095439 BE264590 BE315022 BM707890 
    BF694640 AA313502 BF033194 AW379895 BQ334073 BE207164 BG654377 BE251153 
    BG495166 BE865589 BG476062 AA468392 AW408193 AA313858 BG028624 AI521633 
    BI792035 BE564310 BE515213 BE545055 BM264293 AA334734 AA352130 D53743 
    AA152145 BG822780 CA772686 AA292983 AA361584 Z20287 CD356605 AA191251 
    BF313567 AA653816 BQ225164 BX343081 BG118396 BF670572 BF849649 BE296219 
    AW390393 BE397976 BF669788 BM010417 BE336720 BM720179 BU785977 AJ715204 
    BQ361220 BQ304235 AW675037 AA149988 AA700704 BE384601 BM913720 BE746760 
    CD579570 BE882419 BQ082592 AW248335 AA379226 AW406728 BM172054 CD579205 
    AA373149 BM997946 BG826467 BU660549 BM845979 AA374467 BE786811 BG167861 
    AA373249 AA320318 BU932286 BE173568 AW366767 AV734669 BG722198 BM352824 
    BF700727 H45861 BG253454 AW405927 BQ694567 AW406768 C05407 BG926585 
    BG333452 BF696954 BF821563 AA337676 Z20909 D52939 AV721194 BF103647 
    BM759945 AJ573157 BF304553 AW020747 BM006707 CB268694 CB177179 BF028301 
    CA407094 AA353692 AV716690 CB116127 F27905 BF965435 BE568322 BE796138 
    AW363159 AA352096 BF028365 BE567926 BE564678 BF102797 D53871 CB270206 
    BI869132 H62625 T91471 W94382 AA046134 AA143215 BE394554 BE560601 
    AW249430 AV748572 BF131332 BE562517 CA773236 BU790376 N85688 CD610055 
    BE729710 CF618833 BE865948 BG568308 BM999291 BE549066 AI432978 AW390394 
    AA808814 AA362520 AA862187 AA320768 AV722506 AA078972 AW238330 BE091195 
    D54908 BX413572 BQ694043 CD610057 AA373027 BM468015 N98586 AA301065 
    CD610056 AA354367 AA156257 BU564510 AA306988 BE563916 AA338273 AA079452 
    BX452785 BF961290 AW408178 BF667032 AA115153 CB069357 BU156921 BF126135 
    CD692365 AA090109 BE872147 CB218754 AA329161 BQ213795 AA180350 AA581731 
    CD610059 BG899559 BM794841 AA094763 BU949930 BI046966 BE884278 BG899027 
    AA369803 BU963468 BX363106 BM798352 BE440207 CA773216 D53533 AJ715005 
    AA364586 CD688732 AA220197 BF211063 BF734565 BF082863 AA158807 BE788465 
    AI654527 N89262 BE566513 AW591628 AA467745 BU941710 BU932756 BM793994 
    BE409933 BI055082 BU566526 R02186 AV754961 AA149690 AA082513 AW390397 
    BI868897 BQ361257 AA225385 BF973878 AA075837 AA379288 AA143069 BE539628 
    CD704270 BF175078 BM854457 AW601826 BE971220 AW853164 AA129461 AW814743 
    BG928926 AI567092 AA988235 AW866848 AJ706134 BG654468 AV749849 AI282946 
    AA180034 AW089213 BF215911 AA248368 BF961319 BP432625 BF695884 AA188040 
    BF699121 BM019635 CA942094 BE714671 AA398310 BG897050 AW936037 H24605 
    CD610054 AA131212 BG928908 AW238226 BU790386 BI439134 BE896638 AA075630 
    CA778207 CD579678 AV703928 AW853175 CD690546 AA180079 BF696278 BF807524 
    AA493694 BF203929 BI047041 BG534571 BQ212969 BE882764 BF965182 BU935383 
    N86059 BF132859 BF571858 BF772095 BE567552 CB219812 BF305932 AW247003 
    AA975180 AA747382 BU963237 AA081183 BM905124 AI336509 CD610052 BE258696 
    CD579325 R57151 BE622918 D55533 AJ572833 CD610080 AA482983 AW440755 
    BG390866 BI438211 AJ713857 BU599124 AW578423 AW581035 AA009767 AW604357 
    AW629896 AA320497 AW615006 BU502677 BF029572 AA971421 AW408351 BE564710 
    BM823978 AI469547 C03859 AI890017 BF027817 BQ325734 BI045446 CB219845 
    BE295958 N66448 CF131030 AA191713 AW581081 AA617981 AW581057 BE882955 
    H49617 CD610062 T55475 D55754 CD610053 CD610066 AV726187 AW577068 
    BM752273 AA379410 BG567355 AW581054 BE173531 BF691442 BQ331597 BI045322 
    BG113171 BE566361 CD610076 BF668798 BG425514 BE565833 AV751592 AA102057 
    AV716999 AJ712470 N84604 BF171474 BF830438 BQ640572 BF369533 AW363620 
    CD688935 BG107548 F01236 BF218164 AW581067 N87607 BM810057 BF734142 
    BF171199 CN483782 AA022939 CD523137 BI045263 CD299586 CD610063 CD610081 
    AA094879 BQ286476 AA308147 CD610074 BF852559 AW577490 BQ361255 AA082496 
    AA661987 CD610067 N84969 CD610068 C18918 CD610071 CB177364 CD610070 
    AW805227 BI055065 BF988533 CA952661 BF369526 CD610075 BF806018 BU587686 
    BF849929 AA329318 CD610069 AW238504 CD610064 CD610072 CA848427 BU960493 
    CD610060 AW581070 CD610079 BE960626 R89249 CD610077 AA034245 CD579328 
    AW580989 CD610065 AW889701 BE763497 CD357530 AW794488 AI262870 AA090211 
    AA161090 BF357893 AW386810 BI055072 H97574 N83754 CD610078 BF090430 
    BF308903 AA248346 AV750359 BM782772 BE567968 N85151 AW957562 AV743399 
    AW364686 N89076 BI033141 BI015099 AW580986 BM478270 BF798686 BE539223 
    BQ331512 BF815307 C02650 BG927755 Z20042 AW364687 BI194833 AA081657 
    BF448650 BE535420 AI524964 BE567696 BQ231374 AA164798 AA091222 AW373964 
    AA285335 BF247826 AA187973 BF337007 BI197251 BF229508 AA128838 BG280931 
    AW672681 BF680526 BF697256 AW373968 AA092558 BG031132 BI045290 BI094344 
    AA211766 T73045 BF154459 BU934575 BF993959 AW577075 AW799857 AA917624 
    BQ339803 AW373965 BU537484 AI525466 BU176207 AW804305 BU181130 BE769381 
    BI089111 CA841305 BE866431 BI050852 AA971162 AA729204 BU176292 BF238208 
    BG742203 BF766422 BF808391 AA092186 BU945002 AA523475 CD610073 T55422 
    BF172491 AA157629 BM809151 AW373966 AW605277 N86978 BQ325211 AA095360 
    BF798684 BQ372598 BF837350 BE069068 BF734452 BF082872 BE568924 AW373970 
    AA602392 N85963 AW890396 AW750004 AA091158 AW937080 BQ366340 BG165838 
    BF090450 BE561211 BE940186 BG494295 AI872427 BI044453 AA247954 AW373959 
    CB999990 BF337013 AW577076 AA545794 BF837344 BF336989 BE815057 AI630048 
    AA652844 BE788099 BF096221 BF381596 T57867 AA864966 BI862146 W00410 
    AI905619 T78884 CD102374 BG529970 BU532287 BF841071 AW372931 BU500861 
    BF989512 BE973699 CD523292 BM797750 AI909089 BU929664 AW059893 BQ646641 
    CF597065 AI783543 BG422223 BF671887 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPN11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGTTGA
    PTPN11 Expression
    About this image


    PTPN11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PTPN11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPN11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506852

    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTPN11: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Huntington's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTPN11 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn111 , 5 protein tyrosine phosphatase, non-receptor type 111, 5 87.24(n)1
    99.49(a)1
      5 (61.72 cM)5
    192471  NM_011202.31  NP_035332.11 
     1211305335 
    chicken
    (Gallus gallus)
    Aves PTPN111 protein tyrosine phosphatase, non-receptor type 11 85.33(n)
    98.31(a)
      395815  NM_204968.1  NP_990299.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN116
    protein tyrosine phosphatase, non-receptor type 11...
    97(a)
    1 ↔ 1
    GL343282.1(325794-344135)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9362 Xenopus laevis phosphotyrosyl-protein phosphatase mRNA, more 82.68(n)    U15287.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi24f032 wufi24f03 78.16(n)   333979  BC045328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta csw1 , 3 EGF receptor signaling pathway protein
    tyrosine more3
    corkscrew1
    66(a)3
    61.59(n)1
    66.8(a)1
      452781  NM_001272245.11  NP_001259174.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ptp-23 PROTEIN-TYROSINE PHOSPHATASE 37(a)
    (best of 3)
      II(5918677-5920933)   --


    ENSEMBL Gene Tree for PTPN11 (if available)
    TreeFam Gene Tree for PTPN11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTPN11 gene
    PTPN12  PTPN222  PTPN92  PTPN62  PTPRN22  PTPRN2  PTPN142  PTPN212  
    PTPN20B2  PTPN22  PTPN122  PTPN182  PTPN20A2  
    18 SIMAP similar genes for PTPN11 using alignment to 6 protein entries:     PTN11_HUMAN (see all proteins):
    PTPN6    GRB2    NCK1    GRAP2    VAV3    SHF
    RASA1    CLNK    CSK    VAV1    PIK3R3    SH2B2
    HCK    SHC4    MATK    FYN    LCK    SYK

    Find genes that share paralogs with PTPN11           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for PTPN11 (see all 6)
    PGOHUM00000244574 PGOHUM00000237709 PGOHUM00000245615 PGOHUM00000235162 PGOHUM00000243393


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTPN11 (see all 1464)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0271864
    Noonan syndrome 1 (NS1)4--see VAR_0271862 Q P mis40--------
    VAR_0156184
    Noonan syndrome 1 (NS1)4--see VAR_0156182 N S mis40--------
    VAR_0660604
    Noonan syndrome 1 (NS1)4--see VAR_0660602 T A mis40--------
    VAR_0156224
    Noonan syndrome 1 (NS1)4--see VAR_0156222 R K mis40--------
    VAR_0156074
    Noonan syndrome 1 (NS1)4--see VAR_0156072 A G mis40--------
    VAR_0156174
    Noonan syndrome 1 (NS1)4--see VAR_0156172 F L mis40--------
    VAR_0271974
    Noonan syndrome 1 (NS1)4--see VAR_0271972 L F mis40--------
    VAR_0156234
    Noonan syndrome 1 (NS1)4--see VAR_0156232 S T mis40--------
    VAR_0156044
    Noonan syndrome 1 (NS1)4--see VAR_0156042 D N mis40--------
    VAR_0271934
    LEOPARD syndrome 1 (LEOPARD1)4--see VAR_0271932 R W mis40--------

    HapMap Linkage Disequilibrium report for PTPN11 (112856155 - 112947717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PTPN11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746369CNV Deletion23290073
    esv2661618CNV Deletion23128226
    nsv889CNV Loss18451855
    nsv899524CNV Gain21882294

    Human Gene Mutation Database (HGMD): PTPN11
    Selected Site Specific Mutation Identification with PCR Assays for PTPN11 (see all 16):
    Cosmic IdAA Change
    13014p.A72T
    13026p.E76A
    13000p.E76K
    13025p.E76V
    13020p.S502P
    Selected Site Specific Cancer Mutation PCR Panels containing PTPN11 (see all 6):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Lymphoid Neoplasms
    Hematopoietic Neoplasms
    c-MET
    Cancer Comprehensive Panel 384HT
    SeqTarget long-range PCR primers for resequencing PTPN11
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176876   
    OMIM disorders: 163950  151100  607785  156250  
    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
  • LEOPARD syndrome 1 (LEOPARD1) [MIM:151100]: A disorder characterized by lentigines, electrocardiographic
    conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of
    growth, and sensorineural deafness. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Noonan syndrome 1 (NS1) [MIM:163950]: A form of Noonan syndrome, a disease characterized by short
    stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated
    ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can
    include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits,
    multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk
    of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of
    myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft
    tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints.
    Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in PTPN11 account
    for more than 50% of the cases
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic
    syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell
    compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes,
    rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Metachondromatosis (MC) [MIM:156250]: A skeletal disorder with radiologic features of both multiple
    exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and
    feet, and enchondromas of the metaphyses of long bones and iliac crest. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for PTPN11 (see all 21):    
    About MalaCards
    ptpn11-related noonan syndrome    ptpn11-related leopard syndrome    noonan syndrome 1    metachondromatosis
    pulmonary valve stenosis    dengue hemorrhagic fever    leopard syndrome    noonan syndrome
    noonan-like/multiple giant cell lesion syndrome    juvenile myelomonocytic leukemia    leopard syndrome 1    neurofibromatosis-noonan syndrome
    neurofibromatosis    noma    cherubism    cardiofaciocutaneous syndrome
    ollier disease    microsporidiosis    influenza    myeloid leukemia

    10 diseases from the University of Copenhagen DISEASES database for PTPN11:
    Noonan syndrome     LEOPARD syndrome     Juvenile myelomonocytic leukemia     Pulmonary valve stenosis
    Costello syndrome     Diabetes mellitus     Hypertrophic cardiomyopathy     Congenital heart defect
    Leukemia     Hypersensitivity reaction type II disease

    Find genes that share disorders with PTPN11           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTPN11 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noonan syndrome 96.2 192 17020470 (4), 18348260 (4), 12161469 (4), 15985475 (3) (see all 99)
    leopard syndrome 93.4 63 15690106 (4), 16679933 (3), 14991917 (3), 16208280 (2) (see all 38)
    juvenile myelomonocytic leukemia 90.3 32 15928039 (2), 15604238 (2), 12717436 (2), 15211660 (2) (see all 26)
    cfc syndrome 88.7 10 18651097 (2), 12384786 (2), 12529707 (2), 20052757 (1) (see all 6)
    neurofibromatosis-noonan syndrome 82.8 3 17020470 (2), 19449407 (1)
    lentigines 79.1 5 19582499 (1), 15470362 (1), 16733669 (1), 18470943 (1) (see all 5)
    short stature 77.6 15 15985475 (1), 16498234 (1), 16804314 (1), 20383758 (1) (see all 15)
    heart defects congenital 70.3 12 18203203 (3), 16461457 (2), 12960218 (1), 20461756 (1) (see all 9)
    pulmonary valve stenosis 66.1 6 11992261 (1), 18678287 (1), 12522798 (1), 17515436 (1) (see all 5)
    x-linked lymphoproliferative syndrome 65.1 1 11313386 (1)

    GeneTests: PTPN11
    GeneReviews: PTPN11
    Genetic Association Database (GAD): PTPN11
    Human Genome Epidemiology (HuGE) Navigator: PTPN11 (48 documents)

    Export disorders for PTPN11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPN11 gene, integrated from 10 sources (see all 1248):
    (articles sorted by number of sources associating them with PTPN11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. (PubMed id 19020799)1, 2, 4, 9 Ko J.M.... Yoo H.W. (J. Hum. Genet. 2008)
    2. Identification of a human src homology 2-containing protein-tyrosine- phosphatase: a putative homolog of Drosophila corkscrew. (PubMed id 1280823)1, 2, 3, 9 Freeman R.M. Jr.... Neel B.G. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype- phenotype correlation, and phenotypic heterogeneity. (PubMed id 11992261)1, 2, 4, 9 Tartaglia M.... Gelb B.D. (Am. J. Hum. Genet. 2002)
    4. Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population. (PubMed id 19160029)1, 4, 9 Narumi Y....Tsukamoto K. (J. Clin. Immunol. 2009)
    5. Analysis of the PTPN11 gene in idiopathic short stature children and Noonan syndrome patients. (PubMed id 18331608)1, 4, 9 Ferreira L.V....Jorge A.A. (Clin. Endocrinol. (Oxf) 2008)
    6. PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. (PubMed id 16533526)1, 4, 9 Yamamoto T....Kojma S. (Leuk. Res. 2006)
    7. PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) mutations and response to growth hormone therapy in children with Noonan syndrome. (PubMed id 15956085)1, 4, 9 Ferreira L.V....Jorge A.A. (J. Clin. Endocrinol. Metab. 2005)
    8. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). (PubMed id 20170098)1, 2, 9 Zhang X.... Zhang Z.Y. (J. Med. Chem. 2010)
    9. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PubMed id 19047918)1, 4, 9 Yoshida N....Kojima S. (Pediatr. Res. 2009)
    10. Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11. (PubMed id 15690106)1, 2, 9 Kalidas K.... Jeffery S. (J. Hum. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5781 HGNC: 9644 AceView: RPL6 Ensembl:ENSG00000179295 euGenes: HUgn5781
    ECgene: PTPN11 Kegg: 5781 H-InvDB: PTPN11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPN11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN11 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PTPN11[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTPN11 gene:
    Search GeneIP for patents involving PTPN11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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