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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN11 Gene

protein-coding   GIFtS: 76
GCID: GC12P112856

Protein Tyrosine Phosphatase, Non-Receptor Type 11

(Previous name: Noonan syndrome 1)
(Previous symbol: NS1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 111 2     EC 3.1.3.483 8
NS11 2 5     SHP22 5
PTP2C2 3 5     Noonan Syndrome 11
Protein-Tyrosine Phosphatase 1D2 3     BPTP32
Protein-Tyrosine Phosphatase 2C2 3     CFC2
PTP-1D2 3     Tyrosine-Protein Phosphatase Non-Receptor Type 112
PTP-2C2 3     SHP-23
SH-PTP22 3     SHPTP23
SH-PTP32 3     Shp23

External Ids:    HGNC: 96441   Entrez Gene: 57812   Ensembl: ENSG000001792957   OMIM: 1768765   UniProtKB: Q061243   

Export aliases for PTPN11 gene to outside databases

Previous GC identifers: GC12P111712 GC12P112333 GC12P112639 GC12P111268 GC12P111319 GC12P109868


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN11 Gene:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to
be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,
mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function
as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is
widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important
for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and
cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for PTPN11 Gene: 
PTPN11 (protein tyrosine phosphatase, non-receptor type 11) is a protein-coding gene. Diseases associated with PTPN11 include noonan syndrome, and dengue hemorrhagic fever, and among its related super-pathways are Development HGF signaling pathway and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include SH3/SH2 adaptor activity and protein domain specific binding. An important paralog of this gene is PTPN1.

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the
signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in
stimulatation of its RhoA binding activity

summary for PTPN11 Gene:
Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups
from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of
kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs
are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.
PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity
phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.
MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been
implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator
of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In
cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN11 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPN11 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPN11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.1

PTPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112856:  view genomic region     (about GC identifiers)

Start:
112,856,155 bp from pter      End:
112,947,717 bp from pter
Size:
91,563 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 11  
Size: 597 amino acids; 68436 Da
Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity).
Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3
(tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine
phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts
with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and
ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT;
the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated);
participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11
phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11
phosphatase activity. Interacts with GAREM isoform 1 (tyrosine phosphorylated); the interaction increases
MAPK/ERK activity and does not affect the GRB2/SOS complex formation
Subcellular location: Cytoplasm
6/8 PDB 3D structures from and Proteopedia for PTPN11 (see all 8):
2SHP (3D)        3B7O (3D)        3MOW (3D)        3O5X (3D)        3TKZ (3D)        3TL0 (3D)    
Secondary accessions: A8K1D9 Q96HD7
Alternative splicing: 3 isoforms:  Q06124-1   Q06124-2   Q06124-3   

Explore the universe of human proteins at neXtProt for PTPN11: NX_Q06124

Explore proteomics data for PTPN11 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding
    site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3.
    Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated
    PDGFRB
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q06124

  • 4/20 DME Specific Peptides for PTPN11 (Q06124) (see all 20)
     WPDHGVP  SRRWFHP  DPTSERW  VVHCSAG 

    PTPN11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPN11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002825.3  NP_542168.1  

    ENSEMBL proteins: 
     ENSP00000376376   ENSP00000340944   ENSP00000437013  
    Reactome Protein details: Q06124
    Human Recombinant Protein Products for PTPN11: 
    EMD Millipore Purified and/or Recombinant PTPN11 Protein
    R&D Systems Recombinant & Natural Proteins for PTPN11 (SHP-2)
    Enzo Life Sciences proteins for PTPN11
    OriGene Purified Protein for PTPN11
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for PTPN11 
    OriGene Custom Protein Services for PTPN11
    GenScript Custom Purified and Recombinant Proteins Services for PTPN11
    Novus Biologicals PTPN11 Proteins
    Novus Biologicals PTPN11 Lysates
    Sino Biological Recombinant Protein for PTPN11
    Sino Biological Cell Lysate for PTPN11 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTPN11 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15133037
    GO:0005737cytoplasm IDA10940933
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0043234protein complex IEA--

    PTPN11 for ontologies           About GeneDecksing



    PTPN11 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
    R&D Systems Antibodies for PTPN11 (SHP-2)
    Cell Signaling Technology (CST) Antibodies for PTPN11  (SHP-2)
    OriGene Antibodies for PTPN11
    OriGene Custom Antibody Services for PTPN11
    GenScript Custom Superior Antibodies Services for PTPN11
    Novus Biologicals PTPN11 Antibodies
    Abcam antibodies for PTPN11
    Cloud-Clone Corp. Antibodies for PTPN11 
    ThermoFisher Antibody for PTPN11
    LSBio Antibodies in human, mouse, rat for PTPN11 

    Assay Products for PTPN11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTPN11
    R&D Systems ELISAs for PTPN11 (SHP-2)         (see all)
    GenScript Custom Assay Services for PTPN11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTPN11 
    Cloud-Clone Corp. CLIAs for PTPN11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    5 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR000980 SH2
     IPR012152 Tyr_Pase_non-rcpt_typ-6/11

    Graphical View of Domain Structure for InterPro Entry Q06124

    ProtoNet protein and cluster: Q06124

    2 Blocks protein domains:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000980 SH2 domain signature


    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Domain: The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing
    proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPN11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN11_HUMAN, Q06124
    Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the
    signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in
    stimulatation of its RhoA binding activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN11:
    protein tyrosine phosphatase,non receptor type 11,with two SH2 domains,expressed in heart,brain,skeletal muscle
    with homology to Drosophila corkscrew,involved in intracellular signal transduction in response to
    PDGF,EGF,insulin,interacting with protein zero related (PZR) for cell signaling,overexpressed in neutrophils
    cells from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in
    signaling pathways)

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IDA15133037
    GO:0004725protein tyrosine phosphatase activity TAS--
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity TAS--
    GO:0005070SH3/SH2 adaptor activity IDA7493946
    GO:0005158insulin receptor binding IPI7493946
         
    PTPN11 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PTPN11:
     Decreased focal adhesion (FA)   Increased cell death in breast  Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         15/26 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Ptpn11) (see all 26):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    PTPN11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTPN11: Ptpn11tm1Rbn Ptpn11tm2Bgn Ptpn11tm1.2Cbm Ptpn11tm1Paw

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTPN11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTPN11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPN11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPN11 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPN11:
    hsa-mir-489 (MIRT003549)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN11
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTPN11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPN11
    Sirion Biotech Customized adenovirus for overexpression of PTPN11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTPN11 (see all 6)
    OriGene ORF clones in mouse, rat for PTPN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    Sino Biological Human cDNA Clone for PTPN11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11
    Sirion Biotech Customized lentivirus for stable overexpression of PTPN11 
                         Customized lentivirus expression plasmids for stable overexpression of PTPN11 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PTPN11
    Search LifeMap BioReagents cell lines for PTPN11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPN11 About   (see all 91)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Neurotrophin signaling pathway0.36
    Renal cell carcinoma0.30
    Signaling of Hepatocyte Growth Factor Receptor0.35
    2Immune response Fc epsilon RI pathway
    Fc-epsilon receptor I signaling in mast cells0.33
    Natural killer cell mediated cytotoxicity0.31
    Immune response Role of DAP12 receptors in NK cells0.32
    3Immune response IFN alpha/beta signaling pathway
    Immune response IFN alpha/beta signaling pathway0.71
    Interferon alpha/beta signaling0.45
    Regulation of IFNA signaling0.71
    4Translation Insulin regulation of translation
    Development CNTF receptor signaling0.43
    ErbB2/ErbB3 signaling events0.31
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    5Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/22 EMD Millipore Pathways for PTPN11 (see all 22)
        Chemotaxis CXCR4 signaling pathway
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response Role of DAP12 receptors in NK cells
    Immune response IL-2 activation and signaling pathway
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades

    3 R&D Systems Pathways for PTPN11
        Adipocytokines & Insulin Signaling
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN11
        Epithelial Adherens Junctions

    3 Cell Signaling Technology (CST) Pathways for PTPN11
        Phosphatases
    MAP Kinase Signaling
    Apoptosis and Autophagy

    5/24 GeneGo (Thomson Reuters) Pathways for PTPN11 (see all 24)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development FGF-family signaling
    Development CNTF receptor signaling
    Development Thrombopoetin signaling via JAK-STAT pathway
    Chemotaxis CXCR4 signaling pathway

    5/46 BioSystems Pathways for PTPN11 (see all 46)
        EGFR1 Signaling Pathway
    Heart Development
    Insulin Signaling
    Type II interferon signaling (IFNG)
    Oncostatin M Signaling Pathway


    5/68        Reactome Pathways for PTPN11 (see all 68)
        Platelet homeostasis
    Prolactin receptor signaling
    Regulation of IFNG signaling
    IRS-mediated signalling
    Signaling by PDGF


    5/10         Kegg Pathways  (Kegg details for PTPN11) (see all 10):
        Jak-STAT signaling pathway
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    Neurotrophin signaling pathway
    Adipocytokine signaling pathway


    PTPN11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/339 Interacting proteins for PTPN11 (Q061241, 2, 3 ENSP000003409444) via UniProtKB, MINT, STRING, and/or I2D (see all 339)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234078Q083452, 3, ENSP000004013974MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 STRING: ENSP00000401397
    GAB1Q134801, 2, 3, ENSP000002629954EBI-297779,EBI-517684 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000262995
    DDR1Q083452, 3, ENSP000004060914MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 STRING: ENSP00000406091
    GRB2P629931, 2, 3, ENSP000003390074EBI-297779,EBI-401755 MINT-7300447 MINT-61552 I2D: score=11 STRING: ENSP00000339007
    ENSG00000137332Q083452, 3MINT-74882 MINT-74883 MINT-74885 MINT-8035995 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/47 biological process terms (GO ID links to tree view) (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IEA--
    GO:0000187activation of MAPK activity IEA--
    GO:0006470protein dephosphorylation ----
    GO:0006629lipid metabolic process ----
    GO:0006641triglyceride metabolic process IEA--

    PTPN11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPN11 for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPN11:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PTPN11

    Compounds for PTPN11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Alexidine dihydrochlorideSelective inhibitor of PTPMT1[1715-30-6]
    Sodium orthovanadateProtein tyrosine phosphatase inhibitor[13721-39-6]
    TCS 401Selective inhibitor of PTP1B[243967-42-2]
    BVT 948Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling[39674-97-0]
    NSC 87877Potent inhibitor of shp2 and shp1 PTP[56990-57-9]

    2 HMDB Compounds for PTPN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PTPN11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dodecane-Trimethylamine-- --target--17139284 17016423 10592235

    10/59 Novoseek inferred chemical compound relationships for PTPN11 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.3 917 9129156 (6), 9582366 (6), 7629070 (6), 19275884 (5) (see all 99)
    phosphotyrosine 82 54 12731888 (2), 11684012 (2), 7681217 (1), 8890167 (1) (see all 41)
    gp 130 72.8 61 10946280 (4), 12593670 (4), 9285712 (3), 12403768 (3) (see all 26)
    phosphatidylinositol 69.5 62 9632795 (3), 8647870 (3), 9565634 (2), 10397152 (2) (see all 45)
    phenylalanine 47.8 12 8622663 (1), 8943348 (1), 9756938 (1), 8959326 (1) (see all 10)
    phenylarsine oxide 47.7 2 7935386 (1)
    inositol 46.3 17 10651806 (1), 11709085 (1), 10623804 (1), 17984366 (1) (see all 16)
    ly294002 44.4 2 14762163 (1), 11335710 (1)
    sodium orthovanadate 42.6 1 10540326 (1)
    echistatin 41.1 5 12399420 (3), 16195423 (1)

    Search CenterWatch for drugs/clinical trials and news about PTPN11 / PTN11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPN11 gene (2 alternative transcripts): 
    NM_002834.3  NM_080601.1  

    Unigene Cluster for PTPN11:

    Protein tyrosine phosphatase, non-receptor type 11
    Hs.506852  [show with all ESTs]
    Unigene Representative Sequence: NM_002834
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531326 ENST00000392597(uc001ttw.1) ENST00000351677(uc001ttx.3)
    ENST00000530818
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTPN11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11
    Clone
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    OriGene clones in human, mouse for PTPN11 (see all 6)
    OriGene ORF clones in mouse, rat for PTPN11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11
    Sirion Biotech Customized lentivirus for stable overexpression of PTPN11 
                         Customized lentivirus expression plasmids for stable overexpression of PTPN11 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PTPN11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTPN11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11

    Additional mRNA sequence: 

    AK289854.1 AK312147.1 BC007869.2 BC008692.1 BC025181.1 BC030949.1 BT007106.1 BX537632.1 
    D13540.1 EU779706.1 EU779707.1 EU779708.1 L03535.1 L07527.1 L08807.1 S78088.1 
    U79291.1 X70766.1 

    18 DOTS entries:

    DT.411692  DT.99944225  DT.91769243  DT.100733832  DT.100656212  DT.121153732  DT.95354784  DT.121153765 
    DT.120647580  DT.70100615  DT.95127024  DT.100783460  DT.121153563  DT.121153748  DT.91871508  DT.92421803 
    DT.120843678  DT.99974908 

    1484 AceView cDNA sequences (see top 24):

    AA352866 CB124529 BE560749 AV708487 BQ605334 BU164316 BX951572 CB132341 
    BC004138 CD676521 BG110389 AA312165 BU078966 BQ214477 BE888230 BI829477 
    CR624575 BE394537 CA777112 AW405347 BI913380 BM914982 AA315486 BF037064 
    BM696283 CB116796 CK430262 AA306101 BI497103 BE266156 BM798036 BE783660 
    BF102663 BF792187 BM473884 BM550524 BM873857 AA307193 BU528497 CF128365 
    AA355554 BF797358 BE790807 BQ677828 CB131938 CR603976 CA441817 CB122615 
    BG898041 BE797081 AA300950 CR605343 BG284893 BG109884 AA313900 AA341207 
    AA377277 NM_000970 AA364282 CR622401 CB147739 BE886762 F29250 AW406003 
    CR610998 BE267900 AA975177 BU526614 CR612863 AV654428 BE409026 CB122576 
    BM794666 C05221 CR599701 BQ417364 BM798157 AL523602 BG109947 AA328180 
    BQ688395 BU079092 BF365510 BE884819 W60378 AA321644 CB149157 BG742360 
    BE778575 CR595727 AI867523 AW238895 BU790436 BI545879 AA382251 CR608788 
    BE296681 BE731235 AI097230 F27501 BG289282 BG499282 BE537402 BU665153 
    BF589532 BM888421 BE542112 BQ648096 BU196052 BE909561 AA374122 AA374206 
    CR605132 AA360833 AA326335 AI718939 AA167295 BM454943 CB153901 AA360905 
    BU509143 BE792341 AA329690 BI438493 BM846323 BE779232 CD651903 BI830346 
    BI223825 BM705443 BE206492 BM749129 CA941003 BE257908 AA311815 CA772394 
    BG504448 AV706576 CR625620 BP430232 BE383217 AA328009 CR605631 CF126191 
    CR618245 AW366764 CB132331 BU185398 BQ683339 BE877108 BQ071929 BI335801 
    BI227225 AA313242 BE880113 BE278721 BQ787748 CB136218 BE897317 CR623025 
    AA306182 AV712841 CF128094 AW405946 BE740256 AA313299 CB115027 BM829804 
    AA360934 AW405713 BU166358 BG109087 BM700074 CB120507 BX114871 BQ632734 
    BM854650 BM471972 AA313712 BM800739 CB123159 BM466459 BQ027469 BE782180 
    AA314302 AA313764 BG110137 AA765096 BC013863 BE378172 BI439081 AA644222 
    D12002 W60287 BE783434 BG109306 BC071912 BQ214278 BE268077 BM802399 
    CR610164 BG035085 AW407086 CB135576 BU160895 CB132371 BE512842 BE383019 
    CD049940 BE278100 BQ214666 AI967970 BM466516 BU074678 AA315537 AA308575 
    CR595147 BU785250 CB140996 CA950580 BE894877 AI924245 BG285724 CF128216 
    BE872857 AW059516 BE018336 BU662058 AW407761 BG178854 BM821286 CF126978 
    BI226799 BF036908 BC032299 BU954243 BG685750 CB118534 AW577511 AA955008 
    BQ220065 BI195958 BI763374 BE395513 CB070137 BQ948122 AW409732 CA773715 
    BM314709 BG341756 CB135032 AJ711722 AA373912 BQ233479 BE613484 CB116565 
    BM799251 BE275519 BG397661 AA373817 AW328321 BE566683 BU615290 AW452748 
    AV714856 BG756426 BE780732 AA313672 CD247402 BI258314 BG330957 BF308065 
    AV657723 AJ705797 BQ440877 BX432532 BG397598 BG768286 BG773571 AA115154 
    CF127435 BE379915 D55297 BG753155 BG757239 BU072858 BM271922 BI086574 
    BC022444 CA947030 BE790565 BG697466 AW407022 BI855778 BP378685 CA413318 
    CD050419 BU517025 BI086643 BM838583 AA661671 BI858114 BI197252 AI831221 
    CD386139 BG825883 BM051534 CF126746 BQ777051 BE538412 BM552223 BM559143 
    CF126572 CB268161 AA343157 AA374911 BQ227694 BF974044 BE892127 BX410405 
    BM016899 CA950080 CB069545 BE540661 BQ272056 AA007561 BF349958 BM798447 
    BM046195 CN481838 BF205126 BU951535 BQ269461 AW406433 BF305275 BG250054 
    BG166380 CA942436 BE880474 AA316342 BG779138 BM083559 BF574432 CB115088 
    BE873726 AW850395 BI223512 BG756451 CF130806 BU509890 BG252635 BF308875 
    BE394053 N44620 CF128104 BG336221 BG987584 BF305227 BE782689 BP347885 
    CF131125 BU170605 BF315077 BE619090 AA360021 BE409740 BU581622 BC020679 
    AW245902 BE151939 BG342071 BG753365 AA330370 BX476536 BU790403 BE616728 
    BG481192 BE379330 BE744329 BI090458 AW407055 BG324273 BE905513 BG111681 
    BM049229 BF036476 BE267768 BF036230 BE788168 BG109318 AV713873 CD697839 
    BG282131 CD639017 BG757564 AA296470 AA582279 AA312972 BQ083113 AA361594 
    AW406286 BI222229 BM353714 AJ712438 BG773327 BI194978 BU175684 AA314831 
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    AV751995 BM509297 BU664970 BQ424450 BI227286 BX410406 BE783854 AA364721 
    BG342106 BM794256 BI712616 BI334116 AA336355 BE786555 CN482690 BF032905 
    BE880286 BC070195 BI114431 D31005 BG825332 BF338612 BG655015 BM457904 
    BU196503 BG033781 CA337323 BE866166 BG767696 BE795180 BE879868 D17554 
    BE560923 BU594965 CB267844 BG113260 CB144127 BF026726 BU951179 AV726598 
    BG661276 BF972602 AA373978 BM017702 BE314109 AJ707260 BE567867 BG744161 
    AA352996 BM051349 BM852776 AA379418 D55733 BF103886 AW956100 BI193826 
    AV763841 BG686414 BE783746 BF663714 AW404887 CA849113 CK126115 BI116289 
    BG165289 BG386023 BE884646 BM511067 BG397420 BG033571 F24104 AI247302 
    BE070294 BG327434 BQ270084 BE265938 CD048641 BG179840 AW954712 AV724384 
    BF037566 BE889549 BE254278 BE782230 BQ065805 BG684743 BG334021 BF305761 
    AA366632 BE880805 AV751759 BG496348 BG927443 AW880571 AV707604 T39807 
    CD513919 BG490978 BE269842 BX403939 N83298 AA720797 BX476441 CF126778 
    BG392830 AW366761 BQ777388 BF973365 BI087195 BF184353 BG328704 BQ421574 
    AA180533 BE910090 BG828401 BE293637 AA953173 AA328827 BE560319 BQ222922 
    BE254404 BE799027 AA307591 BE794423 BE279975 BE866597 BF870358 BG531178 
    BG032870 AI744924 BF125785 BE879149 AW404624 BG030209 BE409024 BF305233 
    BE787587 BQ776400 BG256623 CD386670 BI861641 CA435106 BE278207 AJ711805 
    BE548208 BE266346 AA303669 BM469970 D57284 BU580830 CF454440 CA453836 
    BE874936 CB149115 BX410404 AV727931 BM510391 BI091631 BG332421 BE799827 
    BM852324 AA314797 BF797646 CF128219 BE897652 CB134435 BM854690 BE898208 
    CA772762 BI117567 BM795582 BE783805 AW406954 BG396863 AW515656 BG743142 
    BU078205 AW880578 BI911539 BG821328 BE727726 BE780095 CF127097 BQ581452 
    BE881788 BM353045 X69391 BU170410 BU179955 BQ690785 AI955638 BE618985 
    BE799725 BX373119 BU074733 BQ286309 D55962 AA316528 AW404881 BF036669 
    AW406130 AW327349 AW675430 BM051472 S71022 CD049618 BV174637 CA436162 
    BQ884193 BE392189 BG390667 BF672617 BG825415 BG030131 BX345734 BP871435 
    AA128649 AA385584 BG396281 CB069043 CB114932 BX378566 BI856147 AA370411 
    BG685720 T57948 BQ631925 BM312511 BG032426 BF984247 BG397262 AW405416 
    AA296217 BE383207 BF796788 BE542384 AW859802 BE790626 AA312509 BG534458 
    BM789377 BE388310 BE783225 BE172530 BE410512 BE788580 BG473547 CB115765 
    BM051474 BF037814 AA774837 BG260116 BI226467 BQ213521 BP375694 CB123044 
    BE798716 BE256130 BG685238 BQ652083 BI091217 AA364088 BM697998 AJ710683 
    BG291055 BU171500 AF261087 BQ882846 BQ652577 AA131296 AW956502 BP367958 
    BG121895 AJ706945 BM015895 BM010255 BU172275 AA879167 CD514153 CD243038 
    CF128511 BG529652 BE545458 BG826562 AA372767 BE394728 BG827165 AA373697 
    BM753856 CK004108 N22493 BE875921 BG759457 BF968762 BU193338 CF128487 
    AA375115 BI226089 CB134120 BE257867 CA867618 CA405655 BE910405 AA827416 
    CD640506 BG821483 BQ424164 BI825198 BM312750 BF203203 BI869580 CA405502 
    BM843972 BQ942715 AA330229 BU074751 AW407455 AW405919 BM749172 BG678040 
    BG746461 BG116071 BG339900 BM710695 BE728217 BG826734 BF794997 BE791389 
    BE546609 AA329849 AA311713 BE392802 BM457681 CB121046 BM819165 BE560855 
    AW162904 CF134649 CB131964 BG489824 AA485899 AA359759 BQ066063 BM745833 
    BF973139 BG179583 BE252000 BG756377 BU076484 BM905021 D55806 AA626531 
    BM457428 AV705768 AW406101 BE048108 BG655039 AL703668 BG759315 BI225572 
    BE564659 AW407040 AW406734 AA298857 CF131147 AA340158 CB135402 AA314963 
    BX434329 BU602509 BE568097 BE408857 BU951095 BC031009 BE299740 BF797677 
    BE928662 BF344108 BE872964 BG566899 BM263517 BG821345 AW455209 CF131102 
    BE786029 BE397569 BG392119 BE547810 BG256274 BE258515 BG327165 BP372765 
    AW327711 F35500 CA942096 AA953541 BG285962 BX385707 BG167369 CN484975 
    AA364348 BE612821 F32690 BG828861 BF974485 BG760941 AA773454 BI857774 
    BE786822 BU194640 AV734669 AA342140 C05407 C03293 BI792035 AA468374 
    BQ060090 BG826467 AJ573157 BE882419 D52939 AA808814 W39545 T91471 
    BF961290 BE865632 BE296219 AA313502 AA337676 AA078972 AA353692 CB116127 
    BF310936 AA338273 BE746760 BE729710 H45861 BM468015 AA374467 CA841963 
    BP375692 BE091195 BI856192 H62625 CB270206 AA149988 AW406728 BM759945 
    AI521633 AA330383 BM352824 BF103647 BX343081 BM720179 BE564678 AW406768 
    AW390392 BG253454 BI869132 BE268327 CF618833 AW404969 BQ082592 CD356605 
    D55513 CA407094 AA313858 BE871848 BE563916 BF694640 CB135157 AA862187 
    AA130983 AV721194 AA352130 BE298116 CB146899 BU564510 BF175600 D57217 
    BG926585 CD579570 AA191251 BE567926 BF821563 BE865948 AA358229 BU785977 
    AJ715204 CA777568 AW675037 AW379895 AA320768 BF700727 BE394554 BG714539 
    CD610057 BF028365 BF670572 BE560282 AA384292 BE264590 BG167861 AA143215 
    CB177179 AA354367 BF131332 BE960619 BF304553 BM999291 AW020747 D53871 
    AA373249 N98586 AW249430 BE263638 BF669788 AA653816 BG897057 R57773 
    BG495166 BE384601 AW390394 AV716690 BU660549 AA046134 CD579205 BF965435 
    BF313567 BE871738 BG568308 BQ225164 BQ304235 CD610055 AA468392 AW405927 
    BM997946 AA379220 BI093036 F27905 CB069357 BE207164 AA361584 BM006707 
    BQ878702 AA320318 AA334734 AA152145 BF033194 BE568322 BE515213 BE562517 
    BE541000 BE865589 AA379363 BG822780 AA074808 AW408193 N85688 BU169449 
    BG527675 BE796138 BM845979 BQ361220 AA115153 BE251153 BE397976 BE619455 
    BE549066 AA156257 BU790376 AW248335 AW954651 BG333452 AA379226 BM010417 
    AA362520 BQ334073 AV748572 BE315022 BE786811 AW390393 AA188440 BF849649 
    BE792316 BE560601 Z20909 AA352096 BG654377 AI654390 AA970586 CA772686 
    D53743 AA310597 AA095439 CA773236 AW850366 BE336720 CB268694 AW363159 
    BE173568 BG722198 AV722506 AW238330 BX413572 AW601923 BM913720 BM707890 
    BE545055 Z20287 W94382 AA292983 BG028624 BQ694043 AI432978 BF028301 
    D54908 AW408178 AA306988 BG118396 BE564310 BG476062 AA301065 BM264293 
    AW366767 BQ694567 BF082874 BU533638 BM172054 BF667032 BF696954 CD250805 
    BX452785 AA373027 BM313114 BU932286 CF140202 AA700704 CD610056 BF102797 
    AA079452 AA167296 T72271 BM755144 AA373149 BE960887 CB218754 AW238226 
    AA090109 AA248368 BF772095 BQ212969 CD610054 CA773216 CA778207 BE971220 
    BF807524 N89262 AA329161 BU566526 BG928908 AA131212 BG534571 CA942094 
    AA075837 CD688732 AA220197 BQ361257 AA094763 BF973878 BM854457 AA369803 
    BI055082 BE788465 AI654527 BG654468 BE539628 BF211063 BE884278 AA180034 
    AA188040 AA493694 AW591628 H24605 BG899559 BU156921 BE872147 BE882764 
    BF571858 BX363106 N86059 AV749849 BQ213795 AW853164 AA180350 CD579678 
    BU790386 BG899027 BU935383 AA467745 AW853175 AW390397 BE409933 AJ715005 
    BF175078 AA129461 BF082863 BF734565 AV754961 AA158807 BM798352 BU932756 
    AA143069 BM019635 BP432625 BF961319 AJ706134 CD692365 D53533 BM794841 
    AA988235 BF696278 BG897050 BI047041 BF965182 BI046966 AW814743 BE714671 
    AV703928 BF203929 BE440207 AA149690 AA581731 AW089213 AA379288 AA180079 
    BU941710 BF126135 BM793994 BF699121 AW601826 R02186 AA225385 BF132859 
    BE566513 BE896638 BI868897 BF215911 AA075630 BF695884 AI567092 BI439134 
    AW866848 BU963468 CD690546 BU949930 AI282946 AA364586 CD704270 AA398310 
    AW936037 BG928926 CD610059 AA082513 AJ572833 CD610076 AW581081 BQ325734 
    CD523137 BI045322 AW615006 BQ640572 AV716999 CN483782 BF171474 AW581067 
    AW440755 BM752273 T55475 AW581054 AV751592 D55754 AI890017 BF305932 
    BQ331597 CF131030 AW408351 BF027817 BE882955 CD610080 BE295958 AW363620 
    CD610062 CD688935 BE565833 AA379410 CD610066 BG567355 AW581035 AA102057 
    BF830438 AJ713857 BE567552 BF029572 BF691442 D55533 AA971421 BM810057 
    CD610063 CD579325 AV726187 BG113171 AA975180 F01236 BF734142 CD299586 
    CD610052 BF369533 BG107548 BI045446 BE566361 AW247003 C03859 BM905124 
    BU963237 BU599124 BE622918 R57151 AA482983 AA081183 AA009767 BE258696 
    N84604 AA320497 AI469547 N66448 CB219845 AI336509 BF218164 BM823978 
    N87607 BI438211 BI045263 BE564710 BG390866 AW581057 AA617981 BU502677 
    AW604357 AJ712470 H49617 AW578423 AW629896 CD610053 BE173531 CB219812 
    AA747382 BF171199 BG425514 BF668798 AW577068 AA022939 AA191713 BF369526 
    CD610078 AA161090 H97574 AW581070 CD610070 C02650 BQ361255 AW957562 
    BI055065 AV750359 CD357530 BF806018 BM478270 AA308147 AA248346 AA034245 
    AA094879 BG927755 CD610077 N83754 BU587686 BF357893 CD610081 AW238504 
    Z20042 CD610064 CD610065 AW889701 AA090211 BF988533 N85151 AW386810 
    CB177364 AW805227 CD610075 N89076 BF798686 BU960493 R89249 AA082496 
    CD610072 BF090430 BF849929 BQ331512 CD579328 BI033141 AI262870 AW794488 
    CA848427 BF308903 BE567968 C18918 BI015099 AV743399 CD610068 CD610069 
    CA952661 BE960626 BF852559 AA661987 AW580989 AW580986 BI055072 BM782772 
    BQ286476 AA329318 AW364686 N84969 AW577490 BE539223 CD610071 AW364687 
    BE763497 CD610067 CD610074 BF815307 CD610079 CD610060 BU537484 BE567696 
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    AW799857 AW373968 AA157629 BI094344 BI197251 BG742203 BG280931 AA092558 
    AW672681 AA729204 BF247826 BF238208 T73045 BG031132 BI050852 BF808391 
    BU176292 AA285335 AA128838 AA091222 AW577075 CA841305 AA523475 BU945002 
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    BI194833 BI045290 BF337007 AW373965 BF697256 BF993959 AA164798 AA971162 
    BU181130 BU176207 N85963 BF090450 CB999990 AW750004 AA091158 BF837350 
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    AW890396 BG494295 BF798684 BQ325211 AW373970 BE568924 AW373959 AW605277 
    BE069068 AA247954 AA545794 AW373966 BE815057 N86978 AI872427 AA095360 
    BF336989 BQ372598 BF337013 BM809151 BE940186 AA602392 BG165838 BF841071 
    BE788099 AW372931 BE973699 BF989512 CF597065 BF671887 BU929664 AI783543 
    BU500861 AI630048 AA864966 CD102374 BF096221 W00410 BI862146 CD523292 
    AW059893 BQ646641 BF381596 AI905619 T57867 BU532287 T78884 BM797750 
    BG529970 AI909089 BG422223 AA652844 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN11 expression in normal human tissues (normalized intensities)      PTPN11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGTTGA
    PTPN11 Expression
    About this image


    PTPN11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
             sperm   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See PTPN11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN11

    SOURCE GeneReport for Unigene cluster: Hs.506852

    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN11: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Huntington's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTPN11 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn111 , 5 protein tyrosine phosphatase, non-receptor type 111, 5 87.24(n)1
    99.49(a)1
      5 (61.72 cM)5
    192471  NM_011202.31  NP_035332.11 
     1211305335 
    chicken
    (Gallus gallus)
    Aves PTPN111 protein tyrosine phosphatase, non-receptor type 11 85.33(n)
    98.31(a)
      395815  NM_204968.1  NP_990299.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN116
    Uncharacterized protein
    97(a)
    1 ↔ 1
    GL343282.1(325794-344135)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9362 Xenopus laevis phosphotyrosyl-protein phosphatase mRNA, more 82.68(n)    U15287.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi24f032 wufi24f03 78.16(n)   333979  BC045328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta csw1 , 3 EGF receptor signaling pathway protein
    tyrosine more3
    corkscrew1
    66(a)3
    60.95(n)1
    66.1(a)1
      452781  NM_057782.31  NP_477130.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ptp-21 , 3 PROTEIN-TYROSINE PHOSPHATASE3
    Protein Tyrosine Phosphatase1
    37(a)
    (best of 3)3
    50.63(n)1
    44.31(a)1
      II(5918677-5920933)3
    1740031  NM_062783.41  NP_495184.11 


    ENSEMBL Gene Tree for PTPN11 (if available)
    TreeFam Gene Tree for PTPN11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN11 gene
    PTPN12  PTPRH2  PTPN222  PTPRO2  PTPN92  PTPN62  PTPRQ2  PTPRJ2  
    PTPN182  PTPN122  PTPN22  PTPRB2  
    18 SIMAP similar genes for PTPN11 using alignment to 6 protein entries:     PTN11_HUMAN (see all proteins):
    PTPN6    GRB2    NCK1    GRAP2    VAV3    SHF
    RASA1    CLNK    CSK    VAV1    PIK3R3    SH2B2
    HCK    SHC4    MATK    FYN    LCK    SYK

    PTPN11 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for PTPN11 (see all 6)
    PGOHUM00000244574 PGOHUM00000237709 PGOHUM00000245615 PGOHUM00000235162 PGOHUM00000243393


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1464 SNPs in PTPN11 are shown (see all 1464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0271864
    Noonan syndrome 1 (NS1)4--see VAR_0271862 Q P mis40--------
    VAR_0156184
    Noonan syndrome 1 (NS1)4--see VAR_0156182 N S mis40--------
    VAR_0660604
    Noonan syndrome 1 (NS1)4--see VAR_0660602 T A mis40--------
    VAR_0156224
    Noonan syndrome 1 (NS1)4--see VAR_0156222 R K mis40--------
    VAR_0156074
    Noonan syndrome 1 (NS1)4--see VAR_0156072 A G mis40--------
    VAR_0156174
    Noonan syndrome 1 (NS1)4--see VAR_0156172 F L mis40--------
    VAR_0271974
    Noonan syndrome 1 (NS1)4--see VAR_0271972 L F mis40--------
    VAR_0156234
    Noonan syndrome 1 (NS1)4--see VAR_0156232 S T mis40--------
    VAR_0156044
    Noonan syndrome 1 (NS1)4--see VAR_0156042 D N mis40--------
    VAR_0271934
    LEOPARD syndrome 1 (LEOPARD1)4--see VAR_0271932 R W mis40--------

    HapMap Linkage Disequilibrium report for PTPN11 (112856155 - 112947717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PTPN11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746369CNV Deletion23290073
    esv2661618CNV Deletion23128226
    nsv889CNV Loss18451855
    nsv899524CNV Gain21882294


    Human Gene Mutation Database (HGMD): PTPN11
    5/16 SABiosciences Cancer Mutation PCR Assays for PTPN11 (see all 16):
    Cosmic IdAA Change
    13014p.A72T
    13026p.E76A
    13000p.E76K
    13025p.E76V
    13020p.S502P
    5/6 SABiosciences Cancer Mutation PCR Arrays containing PTPN11 (see all 6):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Lymphoid Neoplasms
    Hematopoietic Neoplasms
    c-MET
    Cancer Comprehensive Panel 384HT
    SeqTarget long-range PCR primers for resequencing PTPN11
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176876   
    OMIM disorders: 163950  151100  607785  156250  
    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
  • LEOPARD syndrome 1 (LEOPARD1) [MIM:151100]: A disorder characterized by lentigines, electrocardiographic
    conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of
    growth, and sensorineural deafness. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Noonan syndrome 1 (NS1) [MIM:163950]: A syndrome characterized by facial dysmorphic features such as
    hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short
    stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable
    intellectual deficits. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the jaw
    or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in
    the jaw or joints. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic
    leukemia (JMML). NS1 inheritance is autosomal dominant
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic
    syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell
    compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes,
    rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Metachondromatosis (MC) [MIM:156250]: A skeletal disorder with radiologic features of both multiple
    exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and
    feet, and enchondromas of the metaphyses of long bones and iliac crest. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/114 diseases for PTPN11 (see all 114):    About MalaCards
    noonan syndrome    dengue hemorrhagic fever    ptpn11-related noonan syndrome    ptpn11-related leopard syndrome
    leopard syndrome 1    metachondromatosis    noonan syndrome 1    leopard syndrome
    juvenile myelomonocytic leukemia    neurofibromatosis-noonan syndrome    noonan-like/multiple giant cell lesion syndrome    pulmonary valve stenosis
    noonan syndrome 5    costello syndrome    cherubism    neurofibromatosis
    cardiofaciocutaneous syndrome    hydrops fetalis    ollier disease    enchondroma

    10 diseases from the University of Copenhagen DISEASES database for PTPN11:
    Noonan syndrome     LEOPARD syndrome     Juvenile myelomonocytic leukemia     Pulmonary valve stenosis
    Costello syndrome     Diabetes mellitus     Hypertrophic cardiomyopathy     Congenital heart defect
    Leukemia     Hypersensitivity reaction type II disease

    PTPN11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/85 Novoseek inferred disease relationships for PTPN11 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noonan syndrome 96.2 192 17020470 (4), 18348260 (4), 12161469 (4), 15985475 (3) (see all 99)
    leopard syndrome 93.4 63 15690106 (4), 16679933 (3), 14991917 (3), 16208280 (2) (see all 38)
    juvenile myelomonocytic leukemia 90.3 32 15928039 (2), 15604238 (2), 12717436 (2), 15211660 (2) (see all 26)
    cfc syndrome 88.7 10 18651097 (2), 12384786 (2), 12529707 (2), 20052757 (1) (see all 6)
    neurofibromatosis-noonan syndrome 82.8 3 17020470 (2), 19449407 (1)
    lentigines 79.1 5 19582499 (1), 15470362 (1), 16733669 (1), 18470943 (1) (see all 5)
    short stature 77.6 15 15985475 (1), 16498234 (1), 16804314 (1), 20383758 (1) (see all 15)
    heart defects congenital 70.3 12 18203203 (3), 16461457 (2), 12960218 (1), 20461756 (1) (see all 9)
    pulmonary valve stenosis 66.1 6 11992261 (1), 18678287 (1), 12522798 (1), 17515436 (1) (see all 5)
    x-linked lymphoproliferative syndrome 65.1 1 11313386 (1)

    GeneTests: PTPN11
    GeneReviews: PTPN11
    Genetic Association Database (GAD): PTPN11
    Human Genome Epidemiology (HuGE) Navigator: PTPN11 (48 documents)

    Export disorders for PTPN11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN11 gene, integrated from 9 sources (see all 1230):
    (articles sorted by number of sources associating them with PTPN11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. (PubMed id 19020799)1, 2, 4, 9 Ko J.M....Yoo H.W. (2008)
    2. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. (PubMed id 1280823)1, 2, 3, 9 Freeman R.M....Neel B.G. (1992)
    3. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype- phenotype correlation, and phenotypic heterogeneity. (PubMed id 11992261)1, 2, 4, 9 Tartaglia M.... Gelb B.D. (2002)
    4. Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population. (PubMed id 19160029)1, 4, 9 Narumi Y....Tsukamoto K. (2009)
    5. Analysis of PTPN11 gene in idiopathic short stature children and Noonan syndrome patients. (PubMed id 18331608)1, 4, 9 Ferreira L.V....Jorge A.A. (2008)
    6. PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. (PubMed id 16533526)1, 4, 9 Yamamoto T....Kojma S. (2006)
    7. PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) mutations and response to growth hormone therapy in children with Noonan syndrome. (PubMed id 15956085)1, 4, 9 Ferreira L.V....Jorge A.A. (2005)
    8. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP 2). (PubMed id 20170098)1, 2, 9 Zhang X....Zhang Z.Y. (2010)
    9. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PubMed id 19047918)1, 4, 9 Yoshida N....Kojima S. (2008)
    10. Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11. (PubMed id 15690106)1, 2, 9 Kalidas K.... Jeffery S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5781 HGNC: 9644 AceView: RPL6 Ensembl:ENSG00000179295 euGenes: HUgn5781
    ECgene: PTPN11 Kegg: 5781 H-InvDB: PTPN11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN11 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PTPN11

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPN11 gene:
    Search GeneIP for patents involving PTPN11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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