Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN11 Gene

protein-coding   GIFtS: 73
GCID: GC12P112856

protein tyrosine phosphatase, non-receptor type 11

(Previous name: Noonan syndrome 1 )
(Previous symbol: NS1)
 Explore 117 diseases affiliated with
PTPN11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTPN11    

Aliases
for PTPN11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 111 2     PTP-1D2 3
PTP2C1 2 3 5     PTP-2C2 3
SH-PTP21 2 3     SH-PTP32 3
NS11 2 5     EC 3.1.3.483 8
SHP21 2 5     Noonan Syndrome 11
BPTP31 2     CFC2
SHP-21 3     Tyrosine-Protein Phosphatase Non-Receptor Type 112
Protein-Tyrosine Phosphatase 1D2 3     SHPTP23
Protein-Tyrosine Phosphatase 2C2 3     Shp23

External Ids:    HGNC: 96441   Entrez Gene: 57812   Ensembl: ENSG000001792957   OMIM: 1768765   UniProtKB: Q061243   

Export aliases for PTPN11 gene to outside databases

Previous GC identifers: GC12P111712 GC12P112333 GC12P112639 GC12P111268 GC12P111319 GC12P109868


Summaries
for PTPN11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTPN11:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic
cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as
phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely
expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a
diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell
migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal
transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its
RhoA binding activity

summary for PTPN11:
Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups
from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of
kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs
are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.
PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity
phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.
MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been
implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator
of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In
cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN11


Genomic Views
for PTPN11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN11 gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPN11 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPN11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.1

PTPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112856:  view genomic region     (about GC identifiers)

Start:
 112,856,155 bp from pter      End:
 112,947,717 bp from pter
Size:
 91,563 bases      Orientation:
 plus strand

Proteins
for PTPN11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 11  
Size: 597 amino acids; 68436 Da
Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity). Interacts
with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated),
FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2
domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with
phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction
is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts
with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream
signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this
interaction increases the PTPN11 phosphatase activity. Interacts with GAREM isoform 1 (tyrosine phosphorylated); the
interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation
Subcellular location: Cytoplasm
6 PDB 3D structures from and Proteopedia for PTPN11:
2SHP (3D)        3B7O (3D)        3MOW (3D)        3O5X (3D)        3TKZ (3D)        3TL0 (3D)    
Secondary accessions: A8K1D9 Q96HD7
Alternative splicing: 3 isoforms:  Q06124-1   Q06124-2   Q06124-3   

Explore the universe of human proteins at neXtProt for PTPN11: NX_Q06124

Post-translational modifications:

  • Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site
    • for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3.
    Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06124

    • 4/20 DME Specific Peptides for PTPN11 (Q06124) (see all 20)
     WPDHGVP  SRRWFHP  DPTSERW  VVHCSAG 

    PTPN11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002825.3  NP_542168.1  

    ENSEMBL proteins: 
     ENSP00000376376   ENSP00000340944   ENSP00000437013  
    Reactome Protein details: Q06124
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PTPN11 Protein
    R&D Systems Recombinant & Natural Proteins for PTPN11 (SHP-2)
    Enzo Life Sciences proteins for PTPN11
    OriGene Purified Protein: PTPN11
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for PTPN11 
    GenScript Custom Purified and Recombinant Proteins Services for PTPN11
    Novus Biologicals PTPN11 Proteins
    Novus Biologicals PTPN11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PTPN11

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IDA10940933
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0043234protein complex IEA--


    PTPN11 for ontologies           About GeneDecksing



    PTPN11 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
    R&D Systems Antibodies for PTPN11 (SHP-2)
    Cell Signaling Technology (CST) Antibodies for PTPN11  (SHP-2)
    OriGene Antibodies (see all 11): PTPN11
    OriGene Custom Antibody Services for PTPN11 
    GenScript Custom Superior Antibodies Services for PTPN11
    Novus Biologicals PTPN11 Antibodies
    Abcam antibodies for PTPN11 
    Uscn Antibodies for PTPN11
    ThermoFisher Antibodies for PTPN11

    Assay Products for PTPN11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for PTPN11 (SHP-2)         (see all)
    GenScript Custom Assay Services for PTPN11
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PTPN11

    Protein Domains /
    Families
    for PTPN11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTPN11 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR000980 SH2
     IPR012152 Tyr_Pase_non-rcpt_typ-6/11

    Graphical View of Domain Structure for InterPro Entry Q06124

    ProtoNet protein and cluster: Q06124

    2 Blocks protein families:
    IPB000242 Protein tyrosine phosphatase signature
    IPB000980 SH2 domain signature


    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Domain: The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins
    relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for PTPN11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal
    transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its
    RhoA binding activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN11:
    protein tyrosine phosphatase,non receptor type 11,with two SH2 domains,expressed in heart,brain,skeletal muscle with
    homology to Drosophila corkscrew,involved in intracellular signal transduction in response to
    PDGF,EGF,insulin,interacting with protein zero related (PZR) for cell signaling,overexpressed in neutrophils cells
    from patients with severe congenital neutropenia (defective dephosphorylation of proteins involved in signaling
    pathways)

    Enzyme Number (IUBMB): EC 3.1.3.481 2

    miRNA
    Products:            		miRTarBase miRNAs that target PTPN11:
    hsa-mir-489 (MIRT003549)

    OriGene 3'-UTR Clone: PTPN11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN11
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11 (see all 7)
    OriGene shRNA RFP: PTPN11
    OriGene siRNA: PTPN11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PTPN11

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PTPN11
    Search LifeMap BioReagents cell lines for PTPN11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004725protein tyrosine phosphatase activity TAS--
    GO:0004726non-membrane spanning protein tyrosine phosphatase activity TAS--
    GO:0005070SH3/SH2 adaptor activity IDA7493946
    GO:0005158insulin receptor binding IPI7493946


    PTPN11 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for PTPN11:
     Decreased focal adhesion (FA)   Increased cell death in breast  Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for PTPN11: Ptpn11tm1Rbn Ptpn11tm2Bgn Ptpn11tm1.2Cbm Ptpn11tm1Paw
         15/26 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Ptpn11) (see all 26):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    PTPN11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTPN11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/88 super-pathways (see all 88) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    3Development_CNTF receptor signaling
    8/9 pathways (see all 9)
    		Development_CNTF receptor signaling1.00
    		Immune response_IL-6 signaling pathway0.30
    		Development CNTF receptor signaling1.00
    		Immune response IL-6 signaling pathway0.30
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Development_Leptin signaling via JAK/STAT and MAPK cascades0.25
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Development Leptin signaling via JAK/STAT and MAPK cascades0.25
    4IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74
    5Development HGF signaling pathway
    		Development_Neurotrophin family signaling0.45
    		Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.23
    		Development Neurotrophin family signaling0.45
    		Neurotrophin signaling pathway0.20
    		Signaling of Hepatocyte Growth Factor Receptor0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/22 EMD Millipore Pathways for PTPN11 (see all 22)
        Chemotaxis CXCR4 signaling pathway
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response Role of DAP12 receptors in NK cells
    Immune response IL-2 activation and signaling pathway
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades

    1 R&D Systems Pathway for PTPN11
        Adipocytokines & Insulin Signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTPN11
        Epithelial Adherens Junctions

    3 Cell Signaling Technology (CST) Pathways for PTPN11
        Phosphatases
    MAP Kinase Signaling
    Apoptosis and Autophagy

    5/24 GeneGo (Thomson Reuters) Pathways for PTPN11 (see all 24)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development FGF-family signaling
    Development CNTF receptor signaling
    Development Thrombopoetin signaling via JAK-STAT pathway
    Chemotaxis CXCR4 signaling pathway

    5/44 BioSystems Pathways for PTPN11 (see all 44) 
        Oncostatin M Signaling Pathway
    EGFR1 Signaling Pathway
    Heart Development
    Type II interferon signaling (IFNG)
    IL-3 Signaling Pathway

    5/67        Reactome Pathways for PTPN11 (see all 67)
        Platelet homeostasis
    Prolactin receptor signaling
    Regulation of IFNG signaling
    IRS-mediated signalling
    Signaling by PDGF


    5/8         Kegg Pathways  (Kegg details for PTPN11) (see all 8):
        Jak-STAT signaling pathway
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    Neurotrophin signaling pathway
    Adipocytokine signaling pathway


    PTPN11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/329 Interacting proteins for PTPN11 (Q061241, 2, 3 ENSP000003409444) via UniProtKB, MINT, STRING, and/or I2D (see all 329)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAB1Q134801, 2, 3, ENSP000002629954EBI-297779,EBI-517684 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000262995
    GRB2P629931, 2, 3, ENSP000003390074EBI-297779,EBI-401755 MINT-7300447 MINT-61552 I2D: score=11 STRING: ENSP00000339007
    PECAM1P162842, 3MINT-8033280 MINT-8033310 MINT-8031339 MINT-8033235 MINT-8031324 MINT-8031354 MINT-8033295 I2D: score=3 
    CCKBRP322392, 3, ENSP000003355444MINT-3381499 MINT-3381756 MINT-8037752 MINT-3381410 MINT-3381872 I2D: score=2 STRING: ENSP00000335544
    EGFRP005332, 3, ENSP000002754934MINT-61484 MINT-61492 MINT-61488 MINT-74689 I2D: score=6 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IEA--
    GO:0000187activation of MAPK activity IEA--
    GO:0006470protein dephosphorylation ----
    GO:0006629lipid metabolic process ----
    GO:0006641triglyceride metabolic process IEA--


    PTPN11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTPN11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPN11 for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPN11:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PTPN11

    Compounds for PTPN11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 87877Potent inhibitor of shp2 and shp1 PTP[56990-57-9]

    2 HMDB Compounds for PTPN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PTPN11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dodecane-Trimethylamine-- --target--17139284 17016423 10592235

    10/59 Novoseek chemical compound relationships for PTPN11 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.3 917 9129156 (6), 9582366 (6), 7629070 (6), 19275884 (5) (see all 99)
    phosphotyrosine 82 54 12731888 (2), 11684012 (2), 7681217 (1), 8890167 (1) (see all 41)
    gp 130 72.8 61 10946280 (4), 12593670 (4), 9285712 (3), 12403768 (3) (see all 26)
    phosphatidylinositol 69.5 62 9632795 (3), 8647870 (3), 9565634 (2), 10397152 (2) (see all 45)
    phenylalanine 47.8 12 8622663 (1), 8943348 (1), 9756938 (1), 8959326 (1) (see all 10)
    phenylarsine oxide 47.7 2 7935386 (1)
    inositol 46.3 17 10651806 (1), 11709085 (1), 10623804 (1), 17984366 (1) (see all 16)
    ly294002 44.4 2 14762163 (1), 11335710 (1)
    sodium orthovanadate 42.6 1 10540326 (1)
    echistatin 41.1 5 12399420 (3), 16195423 (1)

    Search CenterWatch for drugs/clinical trials and news about PTPN11 / PTN11 

    Transcripts
    for PTPN11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTPN11 gene (2 alternative transcripts): 
    NM_002834.3  NM_080601.1  

    Unigene Cluster for PTPN11:

    Protein tyrosine phosphatase, non-receptor type 11
    Hs.506852  [show with all ESTs]
    Unigene Representative Sequence: NM_002834
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531326 ENST00000392597(uc001ttw.1) ENST00000351677(uc001ttx.3)
    ENST00000530818

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PTPN11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN11
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN11 (see all 92):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-1260b hsa-miR-374a hsa-miR-578 hsa-miR-138-2* hsa-miR-3916 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11 (see all 7)
    OriGene shRNA RFP: PTPN11
    OriGene siRNA: PTPN11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PTPN11 (NM_002834)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTPN11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11

    Additional cDNA sequence: 

    AK289854.1 AK312147.1 BC007869.2 BC008692.1 BC025181.1 BC030949.1 BT007106.1 BX537632.1 
    D13540.1 EU779706.1 EU779707.1 EU779708.1 L03535.1 L07527.1 L08807.1 S78088.1 
    U79291.1 X70766.1 

    18 DOTS entries:

    DT.411692  DT.99944225  DT.100733832  DT.91769243  DT.100656212  DT.121153732  DT.95354784  DT.121153765 
    DT.120647580  DT.70100615  DT.95127024  DT.100783460  DT.121153563  DT.121153748  DT.91871508  DT.92421803 
    DT.120843678  DT.99974908 

    1484 AceView cDNA sequences (see top 24):

    CR605343 CD049940 BF102663 BG742360 BF365510 BF037064 CB122576 AV712841 
    BE542112 BE886762 BM550524 AA765096 BG898041 AA341207 BG284893 BI830346 
    BM794666 CD651903 AA364282 AA313299 BM873857 CB123159 AA382251 BE740256 
    W60287 CF128094 AA314302 BU185398 BE792341 AI097230 BG285724 AW405946 
    AW059516 BU160895 AA307193 BG289282 CB131938 BP430232 AW406003 AA315537 
    BE880113 BE383217 CR610164 BC004138 CA950580 BQ683339 BE278100 F29250 
    BQ417364 BU528497 BI227225 AA306182 AA352866 BU790436 BM888421 BE877108 
    AA321644 BM473884 BE797081 BF589532 CD676521 CR599701 BE782180 AI967970 
    BI497103 BQ787748 BE267900 CB147739 BQ677828 BE383019 AA644222 BG109884 
    AA329690 CF126191 BQ071929 AA360833 BQ688395 BM854650 C05221 BE909561 
    BC071912 BM696283 BU526614 BX951572 BE296681 CA441817 BU196052 BI223825 
    BE266156 BG178854 CB116796 AV706576 BU164316 BM914982 CA772394 BG110137 
    CF128216 BM800739 BM798157 D12002 BE206492 AA360934 BU074678 BE779232 
    BQ214477 W60378 CF126978 CR595727 BX114871 AI924245 AA374206 BQ214278 
    BE790807 CR595147 BE897317 CB136218 AW407761 AW405347 BM454943 BQ027469 
    CR624575 CR610998 CR618245 AA377277 BM466516 BE394537 BG499282 CR625620 
    BE537402 AI867523 BU078966 BQ605334 BE268077 BM705443 BM749129 BF792187 
    BU662058 BF797358 BU509143 BI439081 AI718939 AA306101 BU166358 BE783660 
    AA315486 CB132331 AA300950 BQ214666 BI438493 CR603976 CR622401 BE778575 
    AA312165 BG035085 CB149157 BG109087 BE888230 NM_000970 CB135576 CB132341 
    BE783434 BE278721 AW405713 BI829477 BI545879 BM466459 AA328009 BM700074 
    BI335801 AA328180 BQ648096 BM846323 AA308575 BQ632734 F27501 BG109306 
    BM471972 AL523602 BM821286 CB140996 BG109947 BC013863 AA355554 BM802399 
    BE257908 BE731235 CR608788 AW238895 CB153901 CF128365 AA311815 CB132371 
    CB120507 BE512842 BE409026 BU079092 BM829804 AA313712 AA374122 BU785250 
    CA941003 AA313764 CR605631 AA975177 AV654428 CA777112 BI913380 CR623025 
    AV708487 BE884819 BE018336 BE872857 BG110389 BU665153 CR605132 AA360905 
    AA326335 AW407086 AW366764 AA167295 BE894877 CR612863 BM798036 AA313900 
    CK430262 BG504448 CB122615 BE560749 CB124529 AA313242 CB115027 BE378172 
    AA128649 BX434329 AW880578 BG032426 AW956100 BM049229 BM819165 BG529652 
    BM559143 D31005 BE884646 BP378685 CB121046 BQ948122 BI195958 BF973365 
    AA007561 BQ421574 BE880805 AI744924 AA330370 BI869580 BQ652083 D55733 
    BE265938 BP372765 BG392119 BG033571 CB134435 BX410405 BG397262 AW880571 
    AW406734 AA582279 AA312972 AA314831 CD048641 BI763374 BG825883 AA774837 
    AA364348 CB118534 BG685720 BG330957 BF305275 BM511067 BE928662 BU517025 
    BM552223 D57284 AA364721 BM051534 BE269842 BG756426 CD050419 BE786029 
    BI197252 CF131102 CA413318 BX476536 AW327349 BI227286 BE397569 CF134649 
    BG342071 CB131964 BU509890 AJ707260 BG686414 BE879868 BE408857 AW452748 
    AA364088 BG825332 BM353714 AA298857 BI091217 CB114932 BI861641 AA375115 
    AA330229 BM263517 BQ942715 CA405502 BG753365 BE881788 BF315077 AA626531 
    BF349958 AA115154 CA453836 BU602509 BG534458 BE548208 AA316528 BM469970 
    BE546609 BE616728 BM312750 AV713873 AA180533 BE780732 BF794997 CB070137 
    CD514153 BE256130 CA950080 BU954243 AJ711722 BG826734 BG113260 BU580830 
    BG390667 BG397598 BE394728 CF131147 CA436162 BM697998 BE910090 AA953541 
    BG324273 BI334116 BE254278 CN484975 BG392830 CB069545 AA485899 CB116565 
    CB144877 BE905513 D55962 BQ652577 BE538412 BE568097 BI226467 CB069043 
    BE783746 BF205126 CF127097 BG394227 BU072858 BM852776 BI116289 BE560319 
    BU170410 BE866166 BG285962 AW406286 BG256623 CA849113 BM314709 BG987584 
    BI222229 CA772762 AV714856 CA942436 BE791389 BG827165 BE564659 CB149115 
    BG490978 BF305233 BE070294 BU193338 CD639017 AA360343 CA435106 BU179955 
    BM016899 BX385707 D17554 BG386023 BG033781 BG282131 AA773454 BQ213521 
    BE410512 BE257867 BF574432 BE266346 BI117567 BG166380 AA303669 BU170605 
    BM015895 AV751995 AA385584 BI194978 CD049618 AA352996 CD386670 BE267768 
    BM017702 BG030131 AA379418 BE293637 BG179840 BU078205 AI247302 CF127435 
    CA337323 BM312511 BM852324 BE889549 BE873726 BG759315 BE892127 AW577511 
    BE786596 BI090458 BF974044 BF203203 AW406101 BG260116 BE799827 BG250054 
    BG473547 BG032870 AW406954 CD640506 AA373697 BE897652 BF037566 BE788168 
    BM838583 BQ066063 BE799027 AA131296 BF870358 N83298 BM843972 BE275519 
    BE783854 CA773715 CA947030 CF126746 BU171500 AA314963 AA955008 BF184353 
    AA953173 BG328704 BG291055 BM457428 BE613484 BM795582 BG396863 BM799251 
    BF797646 BE560855 BM010255 BG489824 BG336221 BF984247 BE910405 CB135032 
    AW327711 BE619090 BU196503 CB268161 BX410404 BE790565 CB267844 T57948 
    BG496348 AA361594 BG109318 AW407022 AV724384 BI086574 BU790403 CN482690 
    AW366761 BE379915 CF131125 AL703668 BI114431 BE795180 BG655039 BE383207 
    BG821328 BE798716 BF103886 BE545458 AW245902 BF663714 BE875921 AW404887 
    BU615290 BG179583 BF973139 BG759457 N22493 BF797677 BG116071 BG339900 
    AJ706945 CB115765 BU076484 AA374911 BU074751 BQ440877 BG397420 BE788580 
    AA312509 BF036669 BG342106 BI258314 BE898208 AA343157 AA307591 CK126115 
    BF036476 BE794423 BM353045 BE172530 BG167369 BM051472 BG531178 BE279975 
    BE254404 AA296217 BQ631925 BQ222922 N44620 AW409732 BQ581452 AW404881 
    BI911539 BE314109 BQ882846 BI225572 BU581622 BF036230 BE567867 BQ777388 
    BE409024 BE787587 AW455209 BM509297 BM794256 BX378566 CN481838 BQ065805 
    AA314797 BG927443 BE866597 BE618985 BE872964 BE782689 F24104 CF128219 
    BE879149 BF125785 BG327165 AV726598 BU175684 AV705768 BQ286309 AW162904 
    AA329849 BE379330 AA827416 BF036908 BE542384 BG030209 BE392802 BM749172 
    BG121895 BF338612 BQ777051 BG397661 AW515656 CD247402 BF796788 BV174637 
    BM051474 BM710695 BQ424164 BE278207 BF037814 BX345734 BQ776400 BG753155 
    BG767696 AA373817 CD386139 BQ884193 BM457681 BM798447 BG773327 BE566683 
    BF972602 D55806 BC022444 BC032299 BG165289 BF308065 AA316342 BP347885 
    BF305227 BF308875 BM753856 AV751759 BI855778 BG481192 AJ710683 BE786555 
    CD243038 CA405655 CK004108 BM051349 BG821483 AA313672 BX432532 BQ233479 
    AJ705797 BM789377 BE782230 BQ220065 BU951179 BG685238 BX373119 BG756377 
    CF454440 BG826562 BE540661 BE728217 AI955638 BE880474 AA311713 AW954712 
    BG685750 BG327434 CD513919 BE880286 BE048108 BG661276 AA366632 BI858114 
    AA328827 BE874936 BC020679 BG768286 BE560923 BE790626 BU172275 AA879167 
    BE744329 BM046195 AW404503 T39807 BM905021 BF344108 BQ269461 BP375694 
    BG743142 BG252635 BG334021 BX403939 BG697466 BF026726 BP367958 CB115088 
    F32690 AA360021 BE783225 BG566899 CF128104 BU074733 AJ712438 AW850395 
    AW859802 BC070195 BF672617 BM510391 BI223512 BG779138 BF974485 BM745833 
    AW406433 X69391 BF305761 BQ227694 BU594965 BE783805 BE612821 BG773571 
    CB135402 CA843359 BE258515 BG821345 BE252000 AW406130 BE786822 BQ424450 
    AF261087 BG396281 AW407455 AA359759 BM457904 BG744161 BI086643 AW405919 
    AA373978 AA661671 AV763841 D55297 CF126778 BE151939 AV657723 BG757239 
    BG684743 BM083559 F35500 BE299740 BI193826 AA720797 CA942096 BE727726 
    BI857774 BE780095 BX476441 CB123044 AA370411 BQ690785 BG678040 BE394053 
    AW407040 BU951095 AJ711805 CF126572 CB144127 BE547810 AW956502 BG256274 
    BQ083113 AV727931 BG760941 BG746461 CF128487 AA340158 CF130806 BI856147 
    BE409740 BG828401 BX410406 BI226089 BI713768 BG828861 BM271922 CB134120 
    BI712616 AA316262 BI226799 BE392189 AA336355 AW328321 BG757564 S71022 
    CA867618 BI091631 BG655015 BU664970 BM854690 CF128511 BP871435 BQ270084 
    BQ272056 BU951535 BG111681 AA296470 BI825198 CD697839 AW675430 BE799725 
    BE395513 BI087195 BE388310 AI831221 BG332421 AV707604 AA373912 BG756451 
    AA372767 AW405416 BF032905 BC031009 BG341756 AW407055 BF968762 BG825415 
    AW404624 AA354367 AW850366 BM845979 T91471 H62625 BG926585 AA156257 
    BM999291 BE871738 CD250805 BU790376 BG897057 BE545055 BF670572 BE263638 
    AW238330 AA306988 AA149988 BE619455 BE397976 BF310936 BF696954 AA301065 
    BG476062 BQ694043 BG028624 CD610057 BG822780 BG167861 AW675037 AW366767 
    BE173568 BF028301 CF618833 CD579570 AA358229 BE563916 W39545 BF961290 
    AW601923 BI869132 BG118396 AJ715204 AA352096 BE091195 AW390394 AA095439 
    D55513 CB270206 Z20909 BG826467 BE560282 CA407094 CD610056 BE384601 
    AA046134 BF694640 AI521633 BE394554 F27905 D54908 AA373027 AA313502 
    BE960619 AA468374 AA334734 AA373249 BE882419 AW379895 AV721194 BQ225164 
    BE792316 N85688 BU169449 BE729710 AA188440 BF821563 AA862187 AA320768 
    BE207164 BE564678 BE264590 AA374467 BU533638 BE796138 CA777568 BU785977 
    BG714539 BF175600 BU660549 BE251153 AA700704 BF669788 CB146899 BI093036 
    D52939 AA362520 BG722198 Z20287 BF849649 CA773236 BI856192 AW390392 
    BE564310 AW249430 BF313567 BF102797 BE871848 D53871 BE268327 BU564510 
    BQ304235 BE298116 AA130983 BF667032 CB268694 BF965435 BM006707 D57217 
    BU194640 AA330383 AW954651 BE865632 BE960887 AW406728 BE315022 CA841963 
    BE567926 BM913720 BQ361220 AA079452 AA115153 AA379363 AW020747 BQ082592 
    AJ573157 BM172054 AA320318 BM997946 AI432978 BM755144 BE541000 BM759945 
    AA653816 AA143215 CD579205 CB177179 AA167296 C03293 AA292983 BG495166 
    T72271 AA310597 AW406768 AA342140 R57773 W94382 CD356605 CB116127 
    BG568308 AA361584 BF131332 BQ694567 AA353692 BE568322 AA313858 AW404969 
    BF103647 BX413572 CA772686 AV748572 AW363159 BF033194 BE746760 BP375692 
    BE865948 BE562517 C05407 AA152145 BE549066 AV734669 AA468392 AA191251 
    AI654390 AA970586 AA379220 BG654377 BM352824 BE865589 BM313114 BQ060090 
    BQ334073 AA373149 CB069357 BF028365 AA337676 AW408178 AW408193 D53743 
    BM264293 CD610055 AA352130 BI792035 H45861 BU932286 CF140202 BQ878702 
    BF082874 BM720179 BM707890 AV716690 AA338273 BG333452 AA808814 AW405927 
    BG253454 BF304553 BE336720 BM468015 BE560601 AA379226 AA078972 AA074808 
    BG527675 N98586 BF700727 BE786811 BE515213 BM010417 AV722506 AW390393 
    BE296219 BX343081 AW248335 BX452785 CB135157 AA384292 BG899559 AA398310 
    BX363106 BF571858 BG654468 CD610059 CD692365 AA369803 BF965182 BI439134 
    BG534571 BE882764 AV749849 AJ706134 AW601826 BM793994 BG928908 BU963468 
    BQ361257 BG928926 BF807524 AA075630 BF203929 AA329161 AA180350 N86059 
    AA180079 BF696278 AW936037 BF772095 AA143069 BF973878 BU935383 BE872147 
    BF961319 AA225385 BF734565 CA773216 AJ715005 CD690546 AW390397 AI282946 
    BF175078 BF082863 CD610054 BF126135 BU156921 AV754961 AA090109 BE409933 
    AI654527 N89262 AV703928 BE896638 BE566513 BU790386 BI047041 AW814743 
    AI567092 BE788465 AA379288 AA188040 BF211063 CA778207 BQ212969 BG897050 
    R02186 AW089213 AA094763 BE971220 AW853175 BI055082 CD579678 AA131212 
    AA364586 AA248368 BM794841 BF215911 BU941710 AA581731 AW853164 BQ213795 
    BM798352 AA180034 CA942094 BI868897 BU949930 AA493694 BU932756 BF695884 
    AA129461 CD688732 AA220197 AA149690 AA158807 BE714671 AA988235 D53533 
    BM854457 BI046966 CD704270 AW238226 AW591628 AW866848 BM019635 AA082513 
    AA467745 CB218754 BU566526 BE884278 BE440207 BE539628 BF132859 H24605 
    BF699121 BP432625 AA075837 BG899027 BF029572 CD610080 AA971421 BF668798 
    AA617981 CD610076 F01236 AI336509 AW604357 AW581035 BM752273 BG425514 
    BF734142 CB219845 BU599124 AW629896 AA009767 AA191713 C03859 BF305932 
    BG390866 BE564710 BU502677 AI890017 AW408351 BE258696 CD299586 AA975180 
    AV751592 AW581054 AI469547 BQ331597 BM905124 N84604 CD610063 R57151 
    BM810057 CD579325 BE295958 AA482983 BF171199 BF369533 AW363620 CD610066 
    BE882955 BQ640572 BE173531 BF830438 AW578423 CD523137 AW581067 BF171474 
    CF131030 BE622918 AJ712470 H49617 BG107548 T55475 BF027817 BE566361 
    AW247003 CD610052 AV716999 CN483782 AW581057 BI438211 N87607 AW615006 
    AA102057 AA081183 AA747382 AA320497 CD688935 D55533 AW577068 BM823978 
    BI045263 AJ572833 AV726187 BI045446 AA379410 BG567355 BE565833 BF218164 
    N66448 BU963237 BF691442 BE567552 BQ325734 BI045322 BG113171 CB219812 
    CD610062 AW440755 CD610053 D55754 AA022939 AW581081 AJ713857 BI055065 
    AW889701 BU587686 AW794488 AW238504 AI262870 AW805227 BM478270 C02650 
    CD610070 N84969 AA082496 AA248346 BQ361255 BF798686 AV750359 CD610075 
    BQ331512 BF806018 AA034245 CD610081 CD610068 AV743399 BF849929 CA848427 
    CA952661 BI033141 AW580986 BE539223 AA308147 CD357530 AA661987 CD579328 
    N89076 AW577490 N83754 CD610074 BF357893 BF852559 CD610072 AW957562 
    AA329318 AW364686 BI055072 H97574 BE567968 CD610071 AW581070 BE763497 
    R89249 CD610060 BF815307 CD610078 BQ286476 BI015099 CD610065 BF988533 
    AW386810 N85151 AA090211 AA161090 CD610069 BE960626 CD610064 CD610079 
    AW580989 BU960493 CB177364 BF090430 Z20042 AW364687 BF369526 CD610067 
    BG927755 BF308903 CD610077 C18918 BM782772 AA094879 BI089111 AA187973 
    BE866431 AW373968 AW799857 BU176292 AA164798 AI525466 BU537484 BF154459 
    BI045290 CA841305 BI197251 BQ231374 BF172491 AW373964 BE535420 BG742203 
    T55422 BQ339803 BF766422 BE769381 BF247826 AA285335 BF238208 AW577075 
    AA729204 BF808391 BF697256 AA092558 BG280931 BF993959 AI524964 BI050852 
    AA081657 BF229508 BU934575 BU945002 AA092186 BI194833 AA211766 AA157629 
    BG031132 BF680526 BF337007 AW672681 T73045 AA917624 AW373965 BU176207 
    AA971162 BI094344 BF448650 BE567696 BU181130 CD610073 AA091222 AA523475 
    AA128838 AW804305 AA545794 AW577076 BF837350 BE069068 AA091158 BQ325211 
    BQ366340 N85963 BQ372598 AA095360 BG165838 BE561211 BE940186 BF336989 
    AI872427 BF798684 AW937080 AA247954 BG494295 BF337013 AW373966 BF090450 
    CB999990 N86978 AW890396 BI044453 AA602392 BF082872 AW605277 AW373970 
    BF734452 AW373959 BE568924 AW750004 BE815057 BM809151 BF837344 AW059893 
    AI783543 BE973699 BF381596 T78884 BQ646641 AI905619 BF096221 BF671887 
    BG529970 T57867 BU500861 BE788099 AI909089 AW372931 AA864966 BU532287 
    BF841071 BU929664 CD102374 AI630048 CF597065 W00410 BF989512 BG422223 
    BI862146 AA652844 BM797750 CD523292 

    GeneLoc Exon Structure


    Expression
    for PTPN11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATGTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PTPN11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN11

    SOURCE GeneReport for Unigene cluster: Hs.506852

    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
    Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN11: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat
              Huntington's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTPN11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11

    Orthologs
    for PTPN11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTPN11 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PTPN111 protein tyrosine phosphatase, non-receptor type 11 85.33(n)
    98.31(a)    		   395815  NM_204968.1  NP_990299.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PTPN116
    		 --
    		 97(a)
    		 1 ↔ 1
    		 GL343282.1(325780-343622)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.9362 Xenopus laevis phosphotyrosyl-protein phosphatase mRNA, more 82.68(n)    U15287.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi24f032 wufi24f03 78.16(n)   333979  BC045328.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta csw1 , 3 EGF receptor signaling pathway protein
    tyrosine more3
    corkscrew1    		 66(a)3
    60.95(n)1
    66.1(a)1    		   452781  NM_057782.31  NP_477130.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ptp-21 , 3 PROTEIN-TYROSINE PHOSPHATASE3
    Protein Tyrosine Phosphatase1    		 37(a)
    (best of 3)3
    50.63(n)1
    44.31(a)1    		   II(5918677-5920933)3
    1740031  NM_062783.41  NP_495184.11 


    ENSEMBL Gene Tree for PTPN11 (if available)
    TreeFam Gene Tree for PTPN11 (if available) 

    Paralogs
    for PTPN11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN11 gene
    PTPN72  PTPRH2  PTPN222  PTPRO2  PTPN62  PTPRJ2  PTPRQ2  PTPN182  
    PTPN122  PTPN52  PTPRB2  PTPRR2  
    18/19 SIMAP similar genes for PTPN11 using alignment to 6 protein entries:     PTN11_HUMAN (see all proteins) (see all similar genes):
    PTPN6    GRB2    NCK1    GRAP2    VAV3    SHF
    RASA1    CLNK    CSK    VAV1    PIK3R3    SH2B2
    HCK    SHC4    MATK    FYN    LCK    SYK

    PTPN11 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for PTPN11 (see all 6)
    PGOHUM00000244574 PGOHUM00000237709 PGOHUM00000245615 PGOHUM00000235162 PGOHUM00000243393


    Genomic Variants
    for PTPN11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1151 NCBI SNPs in PTPN11 are shown (see all 1151)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289333861,2
    		C,pathogenic112915523(+) ATGCAA/GATATC 4 N D mis11Minor allele frequency- G:0.00NA 4550
    rs1219184571,2
    		Cpathogenic112926270(+) AGGGAC/TGTTCA 2 T M mis11Minor allele frequency- T:0.00EU 1323
    rs1219184701,2
    		Cpathogenic112926909(+) AGCACA/C/GGTACC 3 Q P R mis10--------
    rs617369141,2
    		C,F,probable-non-pathogenic112888239(+) CATCAC/TGGGCA 4 H syn14Minor allele frequency- T:0.03NS WA NA 4740
    rs1848041431,2
    		C,unknown112892360(+) TTTATA/CTTGAA 2 -- int10--------
    rs1219184651,2
    		Cother112888211(+) GGCTGA/C/G/T 
                GTTGG     		8 E A G V mis10--------
    rs73155291,2
    		C,F,H,--112854795(+) AAAAAA/GTGAGG 2 -- us2k1 tfbs33Minor allele frequency- G:0.01NS NA 408
    rs1446396201,2
    		--112855011(+) TGTGCA/GCCACC 2 -- us2k10--------
    rs1124544441,2
    		C,F,--112855348(+) CTTCCG/CTACCA 2 -- us2k13Minor allele frequency- C:0.15WA CSA 122
    rs123166061,2
    		H--112855395(+) tttaaG/Aagaca 2 -- us2k14Minor allele frequency- A:0.00NS EA 410

    HapMap Linkage Disequilibrium report for PTPN11 (112856155 - 112947717 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PTPN11: --
    Human Gene Mutation Database (HGMD): PTPN11

    5/16 SABiosciences Cancer Mutation PCR Assays for PTPN11 (see all 16):
    Cosmic IdAA Change
    13014p.A72T
    13026p.E76A
    13000p.E76K
    13025p.E76V
    13020p.S502P
    5/6 SABiosciences Cancer Mutation PCR Arrays containing PTPN11 (see all 6):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Lymphoid Neoplasms
    Hematopoietic Neoplasms
    c-MET
    Cancer Comprehensive Panel 384HT
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN11
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPN11

    Disorders / Diseases
    for PTPN11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTPN11 for disorders           About GeneDecksing

    OMIM gene information: 176876   
    OMIM disorders: 163950  151100  607785  156250  
    UniProtKB/Swiss-Prot: PTN11_HUMAN, Q06124
  • Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:151100]. It is an autosomal
    • dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic
    conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth,
    and deafness
  • Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:163950]. Noonan syndrome (NS) is a
    • disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor
    delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the
    jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in
    the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with
    juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant
  • Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric
    • myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and
    2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid
    progenitors to granulocyte-macrophage colony stimulating factor
  • Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:156250]. It is a skeletal disorder with
    • radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple
    enchondromas and osteochondroma-like lesions

    20/117 diseases for PTPN11 (see all 117):    About MalaCards
    noonan syndrome    cafe-au-lait spots    acute myeloid leukemia    noonan-like/multiple giant cell lesion syndrome
    myeloid leukemia    noonan syndrome 1    neurofibromatosis-noonan syndrome    leukemia
    hydrops fetalis    dengue hemorrhagic fever    pulmonary valve stenosis    hypersensitivity reaction type ii disease
    juvenile myelomonocytic leukemia    myelomonocytic leukemia    patent ductus arteriosus    leopard syndrome
    hemorrhagic fever    developmental disabilities    short stature    pulmonic stenosis

    10 diseases from the University of Copenhagen DISEASES database for PTPN11:
    Noonan syndrome     LEOPARD syndrome     Juvenile myelomonocytic leukemia     Pulmonary valve stenosis
    Costello syndrome     Hypertrophic cardiomyopathy     Congenital heart defect     Leukemia
    Cryptorchidism     Gastritis

    10/85 Novoseek disease relationships for PTPN11 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noonan syndrome 96.2 192 17020470 (4), 18348260 (4), 12161469 (4), 15985475 (3) (see all 99)
    leopard syndrome 93.4 63 15690106 (4), 16679933 (3), 14991917 (3), 16208280 (2) (see all 38)
    juvenile myelomonocytic leukemia 90.3 32 15928039 (2), 15604238 (2), 12717436 (2), 15211660 (2) (see all 26)
    cfc syndrome 88.7 10 18651097 (2), 12384786 (2), 12529707 (2), 20052757 (1) (see all 6)
    neurofibromatosis-noonan syndrome 82.8 3 17020470 (2), 19449407 (1)
    lentigines 79.1 5 19582499 (1), 15470362 (1), 16733669 (1), 18470943 (1) (see all 5)
    short stature 77.6 15 15985475 (1), 16498234 (1), 16804314 (1), 20383758 (1) (see all 15)
    heart defects congenital 70.3 12 18203203 (3), 16461457 (2), 12960218 (1), 20461756 (1) (see all 9)
    pulmonary valve stenosis 66.1 6 11992261 (1), 18678287 (1), 12522798 (1), 17515436 (1) (see all 5)
    x-linked lymphoproliferative syndrome 65.1 1 11313386 (1)

    GeneTests: PTPN11
    LEOPARD Syndrome
    Noonan Syndrome

    Genetic Association Database (GAD): PTPN11
    Human Genome Epidemiology (HuGE) Navigator: PTPN11 (48 documents)

    Export disorders for PTPN11 gene to outside databases

    Publications
    for PTPN11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN11 gene, integrated from 9 sources (see all 1200):
    (articles sorted by number of sources associating them with PTPN11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. (PubMed id 1280823)1, 2, 3, 9 Freeman R.M....Neel B.G. (1992)
    2. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype- phenotype correlation, and phenotypic heterogeneity. (PubMed id 11992261)1, 2, 4, 9 Tartaglia M.... Gelb B.D. (2002)
    3. PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) mutations and response to growth hormone therapy in children with Noonan syndrome. (PubMed id 15956085)1, 4, 9 Ferreira L.V....Jorge A.A. (2005)
    4. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP 2). (PubMed id 20170098)1, 2, 9 Zhang X....Zhang Z.Y. (2010)
    5. PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. (PubMed id 19020799)1, 2, 9 Ko J.M....Yoo H.W. (2008)
    6. Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11. (PubMed id 15690106)1, 2, 9 Kalidas K.... Jeffery S. (2005)
    7. Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive). (PubMed id 16679933)1, 2, 9 Ucar C.... Heinritz W. (2006)
    8. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). (PubMed id 11433379)1, 2, 9 Pfrepper K.-I.... Schraven B. (2001)
    9. Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. (PubMed id 18829466)1, 2, 9 Jakob S.... Haendeler J. (2008)
    10. The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (PubMed id 15928039)1, 4, 9 Kratz C.P....Loh M.L. (2005)

    External Searches for PTPN11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTPN11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5781 HGNC: 9644 AceView: RPL6 Ensembl:ENSG00000179295 euGenes: HUgn5781
    ECgene: PTPN11 Kegg: 5781 H-InvDB: PTPN11

    Other Databases showing PTPN11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTPN11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN11 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PTPN11

    Intellectual Property
    for PTPN11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTPN11 gene:
    Search GeneIP for patents involving PTPN11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PTPN11 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PTPN11
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN11
     EMD Millipore Purified and/or Recombinant PTPN11 Protein
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PTPN11 (SHP-2)   Browse Cell Culture Products  
     ELISAs for PTPN11 (SHP-2)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Kinase Activity Assays/Reagents for PTPN11 (SHP-2)  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for PTPN11 (SHP-2)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for PTPN11 (SHP-2)  
     OriGene Antibodies for PTPN11   OriGene shRNA RFP for PTPN11  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPN11   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTPN11  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PTPN11   OriGene 3'-UTR Clone for PTPN11  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTPN11  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PTPN11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTPN11   OriGene Custom Protein Services for PTPN11  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTPN11
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPN11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPN11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPN11
     GenScript Custom Purified and Recombinant Proteins Services for PTPN11 GenScript cDNA clones with any tag delivered in your preferred vector for PTPN11
     GenScript Custom Assay Services for PTPN11 GenScript Custom Superior Antibodies Services for PTPN11
     GenScript Custom overexpressing Cell Line Services for PTPN11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PTPN11  (SHP-2)

     Regulatory tfbs in PTPN11 promoter
     Search Chromatin IP Primers for PTPN11
     RT2 qPCR Primer Assay in human, mouse, rat PTPN11
     GNC Network for PTPN11
     SABiosciences PCR Arrays including human, mouse, rat PTPN11
     Tocris compounds for PTPN11
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs/Proteins for PTPN11
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PTPN11 antibodies
     PTPN11 proteins
     PTPN11 lysates
     Antibodies for PTPN11
     See all of Abcam's Antibodies, Kits and Proteins for PTPN11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PTPN11 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PTPN11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN11
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PTPN11
     SwitchGear Promoter luciferase reporter plasmids for PTPN11
     ThermoFisher Antibodies for PTPN11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN11
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PTPN11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4