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Aliases for PTPN1 Gene

Aliases for PTPN1 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 2 3 5
  • Protein-Tyrosine Phosphatase 1B 3 4
  • EC 3.1.3.48 4 61
  • PTP1B 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 1 3
  • Protein Tyrosine Phosphatase, Placental 3
  • PTP-1B 4

External Ids for PTPN1 Gene

Previous HGNC Symbols for PTPN1 Gene

  • PTP1B

Previous GeneCards Identifiers for PTPN1 Gene

  • GC20P048855
  • GC20P049765
  • GC20P049812
  • GC20P048560
  • GC20P049126
  • GC20P045875

Summaries for PTPN1 Gene

Entrez Gene Summary for PTPN1 Gene

  • The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTPN1 Gene

PTPN1 (Protein Tyrosine Phosphatase, Non-Receptor Type 1) is a Protein Coding gene. Diseases associated with PTPN1 include Diabetes Mellitus, Noninsulin-Dependent and Bubonic Plague. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Development_Leptin signaling via JAK/STAT and MAPK cascades. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is PTPN2.

UniProtKB/Swiss-Prot for PTPN1 Gene

  • Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Tocris Summary for PTPN1 Gene

  • Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinase and phosphorylase enzymes.

Gene Wiki entry for PTPN1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN1 Gene

Genomics for PTPN1 Gene

Regulatory Elements for PTPN1 Gene

Enhancers for PTPN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G050481 2.1 FANTOM5 Ensembl ENCODE dbSUPER 30.4 -27.0 -26974 3.6 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ENSG00000232043 PTPN1 DPM1 CEBPB PSMD10P1 MIR645 PTGIS ADNP-AS1 RNF114 TMEM189
GH20G050269 2.1 FANTOM5 Ensembl ENCODE dbSUPER 30 -231.7 -231744 19.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 NFYC MEF2D CEBPB PTPN1 SNAI1 SLC9A8 LINC01270 ENSG00000232043 SMIM25 MIR645 LINC01273 DPM1
GH20G050301 2.1 FANTOM5 Ensembl ENCODE dbSUPER 27.6 -202.4 -202371 12.4 CREB3L1 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 CEBPB DPM1 PSMD10P1 ENSG00000232043 PTPN1 SLC9A8 LINC01270 SNAI1 LINC01273 MIR645
GH20G050140 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.6 -362.6 -362602 14.1 CREB3L1 ZFP64 DMAP1 YBX1 YY1 ZNF143 NFYC TBX21 SSRP1 GLIS1 SNAI1 SLC9A8 LINC01273 B4GALT5 PTPN1 CEBPB TMEM189 RNF114 TMEM189-UBE2V1 UBE2V1
GH20G050496 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -12.4 -12351 3.7 CBX3 ATF1 ZBTB40 RAD21 ETS1 GATA2 ELK1 ZNF143 FOS CREM ENSG00000232043 PTPN1 CEBPB MIR645 MIR1302-5 RPL36P2 LOC101927512 PARD6B TMEM189 GC20P050480
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTPN1 on UCSC Golden Path with GeneCards custom track

Promoters for PTPN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000138505 1279 3201 MLX CREB3L1 AGO1 ZFP64 YBX1 DMAP1 YY1 ZNF548 SP3 NFYC

Genomic Location for PTPN1 Gene

Chromosome:
20
Start:
50,510,321 bp from pter
End:
50,585,241 bp from pter
Size:
74,921 bases
Orientation:
Plus strand

Genomic View for PTPN1 Gene

Genes around PTPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN1 Gene

Proteins for PTPN1 Gene

  • Protein details for PTPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18031-PTN1_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 1
    Protein Accession:
    P18031
    Secondary Accessions:
    • Q5TGD8
    • Q9BQV9
    • Q9NQQ4

    Protein attributes for PTPN1 Gene

    Size:
    435 amino acids
    Molecular mass:
    49967 Da
    Quaternary structure:
    • Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for PTPN1 Gene

neXtProt entry for PTPN1 Gene

Selected DME Specific Peptides for PTPN1 Gene

P18031:
  • DTCLLLMDKRKDPSSVD
  • YILTQGPL
  • DQLRFSY
  • VVHCSAG
  • RMGLIQT
  • FHYTTWPDFG
  • NRNRYRDVSP
  • GPVVVHCS
  • HCSAGIGR

Post-translational modifications for PTPN1 Gene

  • Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
  • S-nitrosylation of Cys-215 inactivates the enzyme activity.
  • Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.
  • Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PTPN1 Gene

Gene Families for PTPN1 Gene

Graphical View of Domain Structure for InterPro Entry

P18031

UniProtKB/Swiss-Prot:

PTN1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
genes like me logo Genes that share domains with PTPN1: view

Function for PTPN1 Gene

Molecular function for PTPN1 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 1
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Enzyme Numbers (IUBMB) for PTPN1 Gene

Gene Ontology (GO) - Molecular Function for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS --
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 8702689
genes like me logo Genes that share ontologies with PTPN1: view
genes like me logo Genes that share phenotypes with PTPN1: view

Animal Models for PTPN1 Gene

MGI Knock Outs for PTPN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTPN1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPN1 Gene

Localization for PTPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interacts with EPHA3 at the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
endosome 5
plasma membrane 2
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome IDA 21135139
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTPN1: view

Pathways & Interactions for PTPN1 Gene

genes like me logo Genes that share pathways with PTPN1: view

Interacting Proteins for PTPN1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360683%0d%0a9606.ENSP00000356713%0d%0a9606.ENSP00000366306%0d%0a9606.ENSP00000369574%0d%0a9606.ENSP00000263967%0d%0a9606.ENSP00000369581%0d%0a
Selected Interacting proteins: P18031-PTN1_HUMAN ENSP00000360683 for PTPN1 Gene via MINT STRING UniProtKB IID

Symbol External ID(s) Details
INSR
SRC
TRPV6
BCAR1
CAV1

SIGNOR curated interactions for PTPN1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IMP,IEA 22045810
GO:0006987 activation of signaling protein activity involved in unfolded protein response TAS 22013210
GO:0007257 activation of JUN kinase activity IEA --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0009966 regulation of signal transduction IMP 21135139
genes like me logo Genes that share ontologies with PTPN1: view

Drugs & Compounds for PTPN1 Gene

(99) Drugs for PTPN1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tiludronate Approved, Vet_approved Pharma Target, inhibitor 2
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
2-(Oxalyl-Amino)-Benzoic Acid Experimental Pharma Target 0
(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER Experimental Pharma Target 0

(39) Additional Compounds for PTPN1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
VO-OHpic
675848-25-6

(5) Tocris Compounds for PTPN1 Gene

Compound Action Cas Number
Alexidine dihydrochloride Selective inhibitor of PTPMT1 1715-30-6
BVT 948 Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling 39674-97-0
NSC 87877 Potent inhibitor of shp2 and shp1 PTP 56990-57-9
TCS 401 Selective inhibitor of PTP1B 243966-09-8
VO-OHpic Potent PTEN inhibitor 675848-25-6

(5) ApexBio Compounds for PTPN1 Gene

Compound Action Cas Number
BVT 948 PTPs inhibitor,cell-permeable and non-competitve 39674-97-0
Etidronate 2809-21-4
NSC 87877 Shp2 /shp1 PTP inhibitor 56990-57-9
Sodium Orthovanadate PTP inhibitor 13721-39-6
TCS 401 Selective PTP1B inhibitor 243967-42-2
genes like me logo Genes that share compounds with PTPN1: view

Drug Products

Transcripts for PTPN1 Gene

mRNA/cDNA for PTPN1 Gene

Unigene Clusters for PTPN1 Gene

Protein tyrosine phosphatase, non-receptor type 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTPN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN1 Gene

No ASD Table

Relevant External Links for PTPN1 Gene

GeneLoc Exon Structure for
PTPN1
ECgene alternative splicing isoforms for
PTPN1

Expression for PTPN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.2), Bone (9.0), and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTPN1 Gene



Protein tissue co-expression partners for PTPN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTPN1 Gene:

PTPN1

SOURCE GeneReport for Unigene cluster for PTPN1 Gene:

Hs.417549

Evidence on tissue expression from TISSUES for PTPN1 Gene

  • Nervous system(4.4)
  • Eye(4.3)
  • Kidney(3)
  • Muscle(2.8)
  • Blood(2.7)
  • Liver(2.7)
  • Intestine(2.4)
  • Heart(2.2)
  • Lung(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with PTPN1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN1 Gene

Orthologs for PTPN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN1 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia PTPN1 34 35
  • 89.67 (n)
cow
(Bos Taurus)
Mammalia PTPN1 34 35
  • 87 (n)
oppossum
(Monodelphis domestica)
Mammalia PTPN1 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn1 34
  • 81.59 (n)
mouse
(Mus musculus)
Mammalia Ptpn1 34 16 35
  • 81.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN1 34 35
  • 73.4 (n)
lizard
(Anolis carolinensis)
Reptilia PTPN1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn1 34
  • 69.56 (n)
Str.7557 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15249 34
zebrafish
(Danio rerio)
Actinopterygii ptpn1 34 35
  • 63.53 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10706 34
fruit fly
(Drosophila melanogaster)
Insecta Ptp61F 36 35
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea F10G8.1 36
  • 32 (a)
T22C1.8 36
  • 32 (a)
C55B7.3 36
  • 31 (a)
ZK484.7 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for PTPN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN1 Gene

ENSEMBL:
Gene Tree for PTPN1 (if available)
TreeFam:
Gene Tree for PTPN1 (if available)

Paralogs for PTPN1 Gene

Paralogs for PTPN1 Gene

genes like me logo Genes that share paralogs with PTPN1: view

Variants for PTPN1 Gene

Sequence variations from dbSNP and Humsavar for PTPN1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs16989673 other 50,582,819(+) CCGCG(-/G)TAGAG utr-variant-3-prime
rs1000062132 -- 50,528,341(+) TATCA(A/G)GTCTT intron-variant
rs1000108722 -- 50,535,111(+) CTGTG(G/T)TCTTC intron-variant
rs1000145246 -- 50,519,178(+) ACAGT(A/G)TTGGA intron-variant
rs1000153249 -- 50,578,531(+) AGTCA(C/G)GGTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTPN1 Gene

Variant ID Type Subtype PubMed ID
dgv163n111 CNV duplication 26073780
dgv4324n100 CNV gain 25217958
esv2760682 CNV gain 21179565
esv3393507 CNV insertion 20981092
nsv586177 CNV gain 21841781

Variation tolerance for PTPN1 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN1 Gene

Human Gene Mutation Database (HGMD)
PTPN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN1 Gene

Disorders for PTPN1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PTPN1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes, type 2
bubonic plague
  • black death
carbuncle
  • carbuncle and furuncle of any part of face except eye
fructose intolerance
  • fructose intolerance, hereditary
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search PTPN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPN1

Genetic Association Database (GAD)
PTPN1
Human Genome Epidemiology (HuGE) Navigator
PTPN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN1
genes like me logo Genes that share disorders with PTPN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN1 Gene

Publications for PTPN1 Gene

  1. Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. (PMID: 18819921) Sangwan V. … Park M. (J. Biol. Chem. 2008) 3 4 22 64
  2. Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians. (PMID: 17333110) Traurig M. … Baier L.J. (Diabetologia 2007) 3 22 46 64
  3. 1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population. (PMID: 17560463) Meshkani R. … Adeli K. (Arch. Med. Res. 2007) 3 22 46 64
  4. Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. (PMID: 16677372) Cheyssac C. … Vaxillaire M. (BMC Med. Genet. 2006) 3 22 46 64
  5. Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism. (PMID: 15919835) Ukkola O. … Bouchard C. (Obes. Res. 2005) 3 4 46 64

Products for PTPN1 Gene

Sources for PTPN1 Gene