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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPN1 Gene

protein-coding   GIFtS: 74
GCID: GC20P049126

Protein Tyrosine Phosphatase, Non-Receptor Type 1


(Previous symbol: PTP1B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase, Non-Receptor Type 11 2     Protein Tyrosine Phosphatase, Placental2
PTP1B1 2 3 5     Tyrosine-Protein Phosphatase Non-Receptor Type 12
Protein-Tyrosine Phosphatase 1B2 3     PTP-1B3
EC 3.1.3.483 8     

External Ids:    HGNC: 96421   Entrez Gene: 57702   Ensembl: ENSG000001963967   OMIM: 1768855   UniProtKB: P180313   

Export aliases for PTPN1 gene to outside databases

Previous GC identifers: GC20P048855 GC20P049765 GC20P049812 GC20P048560 GC20P045875


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPN1 Gene:
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which
was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis
of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved
catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that
regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic
transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating
the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal
growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell
growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for PTPN1 Gene: 
PTPN1 (protein tyrosine phosphatase, non-receptor type 1) is a protein-coding gene. Diseases associated with PTPN1 include plague, and bubonic plague, and among its related super-pathways are Immune response IFN alpha/beta signaling pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein tyrosine phosphatase activity and protein kinase binding. An important paralog of this gene is PTPRH.

UniProtKB/Swiss-Prot: PTN1_HUMAN, P18031
Function: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein
response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK.
May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the
EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion

summary for PTPN1 Gene:
Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups
from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of
kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs
are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity.
PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity
phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g.
MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been
implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator
of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In
cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPN1 gene promoter:
         Nkx3-1   CREB   PPAR-alpha   Elk-1   Sp1   deltaCREB   STAT3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTPN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1-q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.1-q13.2

PTPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPN1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P049126:  view genomic region     (about GC identifiers)

Start:
49,126,891 bp from pter      End:
49,201,299 bp from pter
Size:
74,409 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTN1_HUMAN, P18031 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type 1  
Size: 435 amino acids; 49967 Da
Subunit: Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and
function
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Note=Interacts with EPHA3 at the cell membrane
6/121 PDB 3D structures from and Proteopedia for PTPN1 (see all 121):
1A5Y (3D)        1AAX (3D)        1BZC (3D)        1BZH (3D)        1BZJ (3D)        1C83 (3D)    
Secondary accessions: Q5TGD8 Q9BQV9 Q9NQQ4

Explore the universe of human proteins at neXtProt for PTPN1: NX_P18031

Explore proteomics data for PTPN1 at MOPED 

Post-translational modifications:

  • UniProtKB: Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the
    following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate
    binding and activity. The active site can be restored by reduction
  • UniProtKB: Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at
    Ser-50
  • UniProtKB: S-nitrosylation of Cys-215 inactivates the enzyme activity
  • UniProtKB: Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting
    EIF2AK3/PERK activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18031

  • 4/9 DME Specific Peptides for PTPN1 (P18031) (see all 9)
     DQLRFSY  VVHCSAG  RMGLIQT  GPVVVHCS 

    PTPN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPN1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265547.1  NP_002818.1  

    ENSEMBL proteins: 
     ENSP00000360683   ENSP00000437732  
    Reactome Protein details: P18031
    Human Recombinant Protein Products for PTPN1: 
    EMD Millipore Purified and/or Recombinant PTPN1 Protein
    R&D Systems Recombinant & Natural Proteins for PTPN1 (PTP1B)
    Enzo Life Sciences proteins for PTPN1
    OriGene Purified Protein for PTPN1
    OriGene Protein Over-expression Lysate for PTPN1
    OriGene MassSpec for PTPN1 
    OriGene Custom Protein Services for PTPN1
    GenScript Custom Purified and Recombinant Proteins Services for PTPN1
    Novus Biologicals PTPN1 Proteins
    Novus Biologicals PTPN1 Lysates
    Sino Biological Recombinant Protein for PTPN1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PTPN1
    Cloud-Clone Corp. Proteins for PTPN1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0005886colocalizes with plasma membrane IDA--

    PTPN1 for ontologies           About GeneDecksing



    PTPN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTPN1
    R&D Systems Antibodies for PTPN1 (PTP1B)
    Cell Signaling Technology (CST) Antibodies for PTPN1  (PTP1B)
    OriGene Antibodies for PTPN1
    OriGene Custom Antibody Services for PTPN1
    GenScript Custom Superior Antibodies Services for PTPN1
    Novus Biologicals PTPN1 Antibodies
    Abcam antibodies for PTPN1
    Cloud-Clone Corp. Antibodies for PTPN1 
    ThermoFisher Antibodies for PTPN1
    LSBio Antibodies in human, mouse, rat for PTPN1 

    Assay Products for PTPN1: 
    EMD Millipore Kits and Assays for the Analysis of PTPN1
    OriGene Custom Assay Services for PTPN1
    R&D Systems ELISAs for PTPN1 (PTP1B)         (see all)
    GenScript Custom Assay Services for PTPN1
    Enzo Life Sciences assays for PTPN1
    Cloud-Clone Corp. ELISAs for PTPN1 
    Cloud-Clone Corp. CLIAs for PTPN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTPN: Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

    4 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase
     IPR012265 Ptpn1/Ptpn2

    Graphical View of Domain Structure for InterPro Entry P18031

    ProtoNet protein and cluster: P18031

    1 Blocks protein domain: IPB000242 Protein tyrosine phosphatase signature

    UniProtKB/Swiss-Prot: PTN1_HUMAN, P18031
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTPN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN1_HUMAN, P18031
    Function: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein
    response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK.
    May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the
    EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for PTPN1:
    protein tyrosine phosphatase,non receptor type 1

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity TAS--
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI10660596
    GO:0008270zinc ion binding IDA18074158
    GO:0016791phosphatase activity ----
         
    PTPN1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTPN1:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ptpn1):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging  skeleton 

    PTPN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTPN1: Ptpn1tm1Bbk Ptpn1tm1Bpk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTPN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTPN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTPN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTPN1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTPN1:
    hsa-mir-210 (MIRT003154)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPN1
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPN1 (see all 40):
    hsa-miR-4291 hsa-miR-1197 hsa-miR-3146 hsa-miR-29a hsa-miR-374c hsa-miR-124 hsa-miR-506 hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidPTPN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTPN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTPN1
    Sirion Biotech Customized adenovirus for overexpression of PTPN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTPN1 (see all 7)
    OriGene ORF clones in mouse, rat for PTPN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTPN1 (NM_002827)
    Sino Biological Human cDNA Clone for PTPN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTPN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTPN1
    Sirion Biotech Customized lentivirus for stable overexpression of PTPN1 
                         Customized lentivirus expression plasmids for stable overexpression of PTPN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTPN1
    Search LifeMap BioReagents cell lines for PTPN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTPN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPN1 About   (see all 30)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha/beta signaling pathway
    Immune response IFN alpha/beta signaling pathway0.71
    Interferon alpha/beta signaling0.45
    Regulation of IFNA signaling0.71
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    4Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    Platelet Aggregation (Plug Formation)0.73
    5Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PTPN1
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response IFN alpha/beta signaling pathway
    Development Leptin signaling via PI3K-dependent pathway

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTPN1 (see all 6)
        Activation of PKA through GPCR
    PKA Signaling
    Apoptotic Pathways Triggered By HIV1
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    3 Cell Signaling Technology (CST) Pathways for PTPN1
        Phosphatases
    Neuroscience
    Glucose / Energy Metabolism

    3 GeneGo (Thomson Reuters) Pathways for PTPN1
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response IFN alpha/beta signaling pathway
    Development Leptin signaling via PI3K-dependent pathway

    5/12 BioSystems Pathways for PTPN1 (see all 12)
        Insulin Signaling
    Leptin signaling pathway
    Prolactin Signaling Pathway
    IGF1 pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes


    5/14        Reactome Pathways for PTPN1 (see all 14)
        Hemostasis
    Regulation of IFNA signaling
    Integrin cell surface interactions
    Interferon alpha/beta signaling
    Interferon gamma signaling


    2         Kegg Pathways  (Kegg details for PTPN1):
        Adherens junction
    Insulin signaling pathway


    PTPN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTPN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for PTPN1 (P180311, 2, 3 ENSP000003606834) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INSRP062132, 3, ENSP000003038304MINT-1894192 MINT-6793759 MINT-6793683 MINT-6800433 MINT-1894168 MINT-6793586 MINT-6793770 MINT-6793645 MINT-6794946 MINT-6800469 MINT-6764950 MINT-6764790 MINT-6793333 MINT-6795135 MINT-6793622 MINT-6793734 MINT-8287625 MINT-6800815 MINT-6793569 MINT-6800357 MINT-6763841 MINT-8292392 MINT-6793701 MINT-8328741 MINT-6793603 MINT-6795340 MINT-6800410 MINT-8292379 MINT-6764587 MINT-6793552 MINT-6763855 MINT-6793665 I2D: score=5 STRING: ENSP00000303830
    SRCP129312, 3, ENSP000003509414MINT-6797096 MINT-6793501 MINT-6794959 MINT-6795286 MINT-6794163 MINT-6795447 MINT-6764626 MINT-6764915 MINT-6795268 MINT-6795409 MINT-6795229 MINT-6794843 MINT-6794810 MINT-6795255 I2D: score=4 STRING: ENSP00000350941
    GHRP109121, 2, 3, ENSP000002308824EBI-968788,EBI-286316 MINT-6797637 MINT-6797735 MINT-6797829 MINT-6797505 MINT-6797446 MINT-6797653 I2D: score=3 STRING: ENSP00000230882
    CAV1Q031352, 3, ENSP000003391914MINT-6793807 MINT-6793849 MINT-6764881 MINT-6764852 MINT-6764866 I2D: score=5 STRING: ENSP00000339191
    BCAR1P569452, 3, ENSP000001623304MINT-6793484 MINT-6793467 MINT-6762444 MINT-6764626 MINT-6793403 I2D: score=4 STRING: ENSP00000162330
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0007596blood coagulation TAS--
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0009966regulation of signal transduction IMP--
    GO:0016311dephosphorylation ----

    PTPN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTPN1 for compounds           About GeneDecksing

    EMD Millipore small molecules for PTPN1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PTPN1

    Compounds for PTPN1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Alexidine dihydrochlorideSelective inhibitor of PTPMT1[1715-30-6]
    Sodium orthovanadateProtein tyrosine phosphatase inhibitor[13721-39-6]
    TCS 401Selective inhibitor of PTP1B[243967-42-2]
    BVT 948Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling[39674-97-0]
    NSC 87877Potent inhibitor of shp2 and shp1 PTP[56990-57-9]

    2 HMDB Compounds for PTPN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/55 DrugBank Compounds for PTPN1 (see all 55)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    2-(Oxalyl-Amino)-Benzoic Acid-- --target--17139284 17016423 10592235
    3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid-- --target--17139284 17016423 10592235
    6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid-- --target--17139284 17016423 10592235
    7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid-- --target--17139284 17016423 10592235
    Compound 9-- --target--17139284 17016423 10592235
    Novo Nordisk a/S Compound-- --target--17139284 17016423 10592235

    10/73 Novoseek inferred chemical compound relationships for PTPN1 gene (see all 73)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 88.6 885 11506178 (8), 9407132 (5), 11136729 (4), 8166206 (4) (see all 99)
    2-(oxalyl-amino)-benzoic acid 85 7 10702277 (2), 16230012 (2), 12697028 (1)
    phosphotyrosine 83.4 62 9922143 (4), 10889023 (2), 11341829 (2), 9756867 (2) (see all 38)
    raytide 74.3 1 8494789 (1)
    1,2-naphthoquinone 65.2 13 17878162 (5), 15727882 (2), 18057784 (2)
    p-nitrophenyl phosphate 63.3 8 12748196 (2), 15924436 (1), 17762161 (1), 10660596 (1) (see all 6)
    vanadate 59.8 5 9050838 (1), 17655273 (1), 15171692 (1), 20236928 (1) (see all 5)
    cysteine 54 48 19253048 (3), 16076179 (3), 9624118 (2), 12802338 (2) (see all 24)
    pyridazine 50.4 8 12150865 (2), 17140831 (2), 15012988 (2)
    benzofuran 48 6 10753467 (2), 11983524 (1), 15537353 (1)

    Search CenterWatch for drugs/clinical trials and news about PTPN1 / PTN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPN1 gene (2 alternative transcripts): 
    NM_001278618.1  NM_002827.3  

    Unigene Cluster for PTPN1:

    Protein tyrosine phosphatase, non-receptor type 1
    Hs.417549  [show with all ESTs]
    Unigene Representative Sequence: NM_002827
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371621(uc002xvl.3 uc010zys.2) ENST00000541713

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    Additional mRNA sequence: 

    AK290638.1 AK299830.1 AK316563.1 BC015660.2 BC018164.1 BT006752.1 M31724.1 M33689.1 

    9 DOTS entries:

    DT.100787381  DT.216658  DT.40280527  DT.305645  DT.95079713  DT.95171755  DT.91838226  DT.97806001 
    DT.99944514 

    24/267 AceView cDNA sequences (see all 267):

    BM550346 AI498509 AU117677 CB150520 AA069973 CA945104 AI200939 AI611145 
    BQ720828 BG680937 NM_002827 BQ641690 CB044616 CA309848 BF056032 AA813442 
    BF795407 BQ130674 BU193045 AA987294 AI347117 BX641947 BU151376 AU138481 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATAAACCA
    PTPN1 Expression
    About this image


    See PTPN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPN1

    SOURCE GeneReport for Unigene cluster: Hs.417549
        SABiosciences Expression via Pathway-Focused PCR Arrays including PTPN1 (see all 8): 
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              Obesity in human mouse rat
              Protein Phosphatases in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTPN1 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpn11 , 5 protein tyrosine phosphatase, non-receptor type 11, 5 81.44(n)1
    83.76(a)1
      2 (87.99 cM)5
    192461  NM_011201.31  NP_035331.31 
     1679320575 
    chicken
    (Gallus gallus)
    Aves PTPN11 protein tyrosine phosphatase, non-receptor type 1 73.32(n)
    79.81(a)
      395688  NM_204875.1  NP_990206.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPN16
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343226.1(2378999-2405287)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152492 Xenopus laevis transcribed sequence with moderate similarity more 77.14(n)    AW644767.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_130924.12   -- 73.38(n)   30081  NM_130924.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ptp61F1 , 3 axon guidance protein tyrosine
    phosphatase3
    Protein tyrosine phosphatase 61F1
    49(a)3
    55.41(n)1
    51.3(a)1
      381601  NM_057339.31  NP_476687.11 


    ENSEMBL Gene Tree for PTPN1 (if available)
    TreeFam Gene Tree for PTPN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPN1 gene
    PTPRH2  PTPN222  PTPRO2  PTPN112  PTPN92  PTPN62  PTPRQ2  PTPRJ2  
    PTPN22  PTPN182  PTPN122  PTPRB2  
    18/26 SIMAP similar genes for PTPN1 using alignment to 3 protein entries:     PTN1_HUMAN (see all proteins) (see all similar genes):
    PTN2    PTPN2    PTPRO    PTPRB    DKFZp686E13109    PTPN13
    PTPN5    PTPRT    PTPRM    PTPN4    PTPRD    BPTP-3
    DKFZp686B1310    DKFZp781C1038    LAR    PTPRF    DKFZp686N0569    DKFZp761A0712

    PTPN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1467 SNPs in PTPN1 are shown (see all 1467)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108541851,2
    C--45890908(+) TTTTT-/T/TT  
            
    GATGA
    1 -- int1 trp31NA 2
    rs60205871,2
    C,A--45904944(+) tctctT/Cttttt 1 -- int1 trp32Minor allele frequency- C:0.25NA CSA 4
    rs114817221,2
    C--45919677(+) CCACA-/T/TTC 
            
    TCTCT
    2 -- int1 cds1 trp30--------
    rs3720947151,2
    C--45919678(+) CACAT-/T/TCTCTCTCTCTC
    T
    /TCTCTCTCTCTCTCT
    CTCTC
    2 -- int1 cds10--------
    rs32156841,2
    C--45943628(+) GTAGAT/-GAGTG 1 -- int13Minor allele frequency- -:0.00CSA 10
    rs1917737611,2
    --49096246(+) AGAGGA/GGGATG 1 -- us2k10--------
    rs783015651,2
    C,F--49096322(+) GGTACG/AAGAAT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1829803971,2
    --49096414(+) AGGAAA/CCTGCA 1 -- us2k10--------
    rs1858126411,2
    --49096515(+) AGAATC/TGGGCA 1 -- us2k10--------
    rs784194321,2
    F--49096522(+) GGCAAC/GACTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTPN1 (49126891 - 49201299 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PTPN1: --

    Human Gene Mutation Database (HGMD): PTPN1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176885   
    OMIM disorders: 125853  
    20/43 diseases for PTPN1 (see all 43):    About MalaCards
    plague    bubonic plague    mitral valve insufficiency    mitral valve stenosis
    leopard syndrome    estrogen-receptor negative breast cancer    insulin resistance    vesiculitis
    obesity, association with    essential hypertension    morbid obesity    obesity
    leishmaniasis    metabolic disorders    diabetic retinopathy    diabetes mellitus
    hypertension    hyperglycemia    atherosclerosis    myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for PTPN1:
    Diabetes mellitus

    PTPN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/24 Novoseek inferred disease relationships for PTPN1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 62.2 122 18846048 (3), 15640130 (3), 12556216 (3), 10444024 (3) (see all 65)
    insulin resistance 60.7 67 11833006 (4), 15031294 (4), 20177806 (4), 17560463 (3) (see all 29)
    insulin sensitivity 55.7 31 15919835 (2), 11703427 (2), 14976221 (2), 16249458 (2) (see all 20)
    bubonic plague 49.2 1 15781408 (1)
    niddm 31.9 11 10444024 (2), 15470600 (1), 15715684 (1), 12678843 (1) (see all 8)
    metabolic disorder 22.5 1 16677372 (1)
    dyslipidemia 10.8 2 19797171 (1), 16644688 (1)
    leishmaniasis 3.23 1 11544330 (1)
    alzheimers disease 2.84 1 7812792 (1)
    inflammation 2.26 2 20026400 (1), 18236007 (1)

    Genetic Association Database (GAD): PTPN1
    Human Genome Epidemiology (HuGE) Navigator: PTPN1 (34 documents)

    Export disorders for PTPN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPN1 gene, integrated from 9 sources (see all 621):
    (articles sorted by number of sources associating them with PTPN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism. (PubMed id 15919835)1, 2, 4, 9 Ukkola O.... Bouchard C. (2005)
    2. Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. (PubMed id 2164224)1, 2, 3 Brown-Shimer S.... Hill D.E. (1990)
    3. Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. (PubMed id 11579209)1, 2, 9 Ravichandran L.V.... Quon M.J. (2001)
    4. Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation. (PubMed id 8491187)1, 2, 9 Flint A.J.... Tonks N.K. (1993)
    5. Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study. (PubMed id 15504985)1, 4, 9 Palmer N.D....Bowden D.W. (2004)
    6. A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro. (PubMed id 11756316)1, 4, 9 Echwald S.M....Pedersen O. (2002)
    7. Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. (PubMed id 16677372)1, 4, 9 Cheyssac C....Vaxillaire M. (2006)
    8. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. (PubMed id 9922143)1, 2, 9 Groves M.R.... Barford D. (1998)
    9. 1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population. (PubMed id 17560463)1, 4, 9 Meshkani R....Adeli K. (2007)
    10. Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. (PubMed id 9355745)1, 2, 9 Liu F. and Chernoff J. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5770 HGNC: 9642 AceView: PTPN1 Ensembl:ENSG00000196396 euGenes: HUgn5770
    ECgene: PTPN1 Kegg: 5770 H-InvDB: PTPN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTPN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPN1 gene:
    Search GeneIP for patents involving PTPN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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