Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTPN1 Gene

Aliases for PTPN1 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 2 3 5
  • Protein-Tyrosine Phosphatase 1B 3 4
  • EC 3.1.3.48 4 63
  • PTP1B 3 4
  • Protein Tyrosine Phosphatase, Placental 3
  • PTP-1B 4

External Ids for PTPN1 Gene

Previous HGNC Symbols for PTPN1 Gene

  • PTP1B

Previous GeneCards Identifiers for PTPN1 Gene

  • GC20P048855
  • GC20P049765
  • GC20P049812
  • GC20P048560
  • GC20P049126
  • GC20P045875

Summaries for PTPN1 Gene

Entrez Gene Summary for PTPN1 Gene

  • The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTPN1 Gene

PTPN1 (Protein Tyrosine Phosphatase, Non-Receptor Type 1) is a Protein Coding gene. Diseases associated with PTPN1 include diabetes mellitus, noninsulin-dependent and bubonic plague. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is PTPRO.

UniProtKB/Swiss-Prot for PTPN1 Gene

  • Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Tocris Summary for PTPN1 Gene

  • Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinase and phosphorylase enzymes.

Gene Wiki entry for PTPN1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN1 Gene

Genomics for PTPN1 Gene

Regulatory Elements for PTPN1 Gene

Promoters for PTPN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTPN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTPN1 Gene

Chromosome:
20
Start:
50,510,321 bp from pter
End:
50,585,241 bp from pter
Size:
74,921 bases
Orientation:
Plus strand

Genomic View for PTPN1 Gene

Genes around PTPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN1 Gene

Proteins for PTPN1 Gene

  • Protein details for PTPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18031-PTN1_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 1
    Protein Accession:
    P18031
    Secondary Accessions:
    • Q5TGD8
    • Q9BQV9
    • Q9NQQ4

    Protein attributes for PTPN1 Gene

    Size:
    435 amino acids
    Molecular mass:
    49967 Da
    Quaternary structure:
    • Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for PTPN1 Gene

neXtProt entry for PTPN1 Gene

Proteomics data for PTPN1 Gene at MOPED

Post-translational modifications for PTPN1 Gene

  • Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
  • S-nitrosylation of Cys-215 inactivates the enzyme activity.
  • Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.
  • Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTPN1 (PTP1B)

Protein Products

Assay Products

  • Enzo Life Sciences assays for PTPN1
  • Cloud-Clone Corp Assay Kits for PTPN1

Domains & Families for PTPN1 Gene

Gene Families for PTPN1 Gene

Graphical View of Domain Structure for InterPro Entry

P18031

UniProtKB/Swiss-Prot:

PTN1_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
genes like me logo Genes that share domains with PTPN1: view

Function for PTPN1 Gene

Molecular function for PTPN1 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 1
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Enzyme Numbers (IUBMB) for PTPN1 Gene

Gene Ontology (GO) - Molecular Function for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 8702689
GO:0016791 phosphatase activity IEA --
GO:0051721 protein phosphatase 2A binding IEA --
genes like me logo Genes that share ontologies with PTPN1: view
genes like me logo Genes that share phenotypes with PTPN1: view

Animal Models for PTPN1 Gene

MGI Knock Outs for PTPN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPN1 Gene

Localization for PTPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interacts with EPHA3 at the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN1 Gene COMPARTMENTS Subcellular localization image for PTPN1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
endosome 5
nucleus 2
plasma membrane 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IEA,TAS --
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane IDA 1739967
genes like me logo Genes that share ontologies with PTPN1: view

Pathways & Interactions for PTPN1 Gene

genes like me logo Genes that share pathways with PTPN1: view

Interacting Proteins for PTPN1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360683%0d%0a9606.ENSP00000303830%0d%0a9606.ENSP00000350941%0d%0a9606.ENSP00000391669%0d%0a9606.ENSP00000275493%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: P18031-PTN1_HUMAN ENSP00000360683 for PTPN1 Gene via MINT I2D UniProtKB STRING

Symbol External ID(s) Details
INSR
SRC
GHR
TRPV6
BCAR1

SIGNOR curated interactions for PTPN1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IMP 22045810
GO:0006987 activation of signaling protein activity involved in unfolded protein response TAS 22013210
GO:0007257 activation of JUN kinase activity IEA --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0009966 regulation of signal transduction IMP 21135139
genes like me logo Genes that share ontologies with PTPN1: view

Drugs & Compounds for PTPN1 Gene

(89) Drugs for PTPN1 Gene - From: Novoseek, DGIdb, DrugBank, ApexBio, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tiludronate Approved Pharma Target, inhibitor 0
2-(Oxalyl-Amino)-Benzoic Acid Experimental Pharma Target 0
(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER Experimental Pharma Target 0
(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid Experimental Pharma Target 0
[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid Experimental Pharma Target 0

(49) Additional Compounds for PTPN1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
BVT 948
39674-97-0
NSC 87877
56990-57-9
genes like me logo Genes that share compounds with PTPN1: view

Drug Products

Transcripts for PTPN1 Gene

mRNA/cDNA for PTPN1 Gene

Unigene Clusters for PTPN1 Gene

Protein tyrosine phosphatase, non-receptor type 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN1 Gene

No ASD Table

Relevant External Links for PTPN1 Gene

GeneLoc Exon Structure for
PTPN1
ECgene alternative splicing isoforms for
PTPN1

Expression for PTPN1 Gene

mRNA expression in normal human tissues for PTPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.2), Bone (9.0), and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN1 Gene



SOURCE GeneReport for Unigene cluster for PTPN1 Gene Hs.417549

genes like me logo Genes that share expression patterns with PTPN1: view

Protein tissue co-expression partners for PTPN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPN1 Gene

Orthologs for PTPN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN1 36
  • 100 (a)
OneToOne
PTPN1 35
  • 99.77 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PTPN1 35
  • 87 (n)
  • 89.6 (a)
PTPN1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN1 36
  • 91 (a)
OneToOne
PTPN1 35
  • 89.67 (n)
  • 91.08 (a)
mouse
(Mus musculus)
Mammalia Ptpn1 16
Ptpn1 35
  • 81.44 (n)
  • 83.76 (a)
Ptpn1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPN1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn1 35
  • 81.59 (n)
  • 85.38 (a)
chicken
(Gallus gallus)
Aves PTPN1 35
  • 73.4 (n)
  • 79.81 (a)
PTPN1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15249 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn1 35
  • 69.56 (n)
  • 73.24 (a)
Str.7557 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10706 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ptpn1 35
  • 63.53 (n)
  • 68.36 (a)
ptpn1 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ptp61F 37
  • 49 (a)
Ptp61F 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C55B7.3 37
  • 31 (a)
F10G8.1 37
  • 32 (a)
T22C1.8 37
  • 32 (a)
ZK484.7 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for PTPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN1 Gene

ENSEMBL:
Gene Tree for PTPN1 (if available)
TreeFam:
Gene Tree for PTPN1 (if available)

Paralogs for PTPN1 Gene

genes like me logo Genes that share paralogs with PTPN1: view

Variants for PTPN1 Gene

Sequence variations from dbSNP and Humsavar for PTPN1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs941798 -- 50,546,698(+) AAAGT(A/G)TCATC intron-variant
rs968701 -- 50,578,711(-) AGGAG(C/T)GCTTC intron-variant
rs1011920 -- 50,555,637(-) AAAAA(C/T)AGATT intron-variant
rs2038526 -- 50,569,112(+) TGACT(C/T)ACCAT intron-variant
rs1883699 -- 50,519,617(-) AGGGT(A/T)ACTAC intron-variant

Variation tolerance for PTPN1 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPN1 Gene

HapMap Linkage Disequilibrium report
PTPN1
Human Gene Mutation Database (HGMD)
PTPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTPN1 Gene

Disorders for PTPN1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PTPN1 Gene - From: OMIM, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
bubonic plague
  • black death
fructose intolerance
  • hereditary fructose intolerance syndrome
glucose metabolism disease
  • disorder of glucose metabolism
overnutrition
- elite association - COSMIC cancer census association via MalaCards
Search PTPN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTPN1

Genetic Association Database (GAD)
PTPN1
Human Genome Epidemiology (HuGE) Navigator
PTPN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPN1
genes like me logo Genes that share disorders with PTPN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN1 Gene

Publications for PTPN1 Gene

  1. Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism. (PMID: 15919835) Ukkola O. … Bouchard C. (Obes. Res. 2005) 3 4 48 67
  2. The two faces of PTP1B in cancer. (PMID: 19782770) Lessard L. … Tremblay M.L. (Biochim. Biophys. Acta 2010) 3 23
  3. Protein tyrosine phosphatase-1B and T-cell protein tyrosine phosphatase regulate IGF-2-induced MCF-7 cell migration. (PMID: 20059965) Blanquart C. … Issad T. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. (PMID: 20131294) Gagarina V. … Hall D.J. (Arthritis Rheum. 2010) 3 23
  5. Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. (PMID: 20236928) BrandALo T.A. … Johnson S.J. (J. Biol. Chem. 2010) 3 23

Products for PTPN1 Gene

  • Addgene plasmids for PTPN1

Sources for PTPN1 Gene

Back to Top

Content