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PTPN1 Gene

protein-coding GIFtS: 72

GC20P048560

protein tyrosine phosphatase, non-receptor type 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PTP1B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.3.48 ^³
OTTHUMP00000031266 ^²
PTP-1B ^³
PTP1B ^², ³, ⁵

Descriptions
Protein-tyrosine phosphatase 1B ^³
protein tyrosine phosphatase 1B ^²
protein tyrosine phosphatase, non-receptor type 1 ^²
protein tyrosine phosphatase, placental ^²

External Ids
HGNC: 9642¹
Entrez Gene: 5770²
UniProtKB: P18031³
Ensembl: ENSG00000196396⁷

Search outside databases for aliases for PTPN1 gene

Previous GC identifers: GC20P048855 GC20P049765 GC20P049812

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PTPN1:

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP)

family, which was isolated and identified based on its enzymatic activity and amino acid sequence.

PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues.

Members of the PTP family share a highly conserved catalytic motif, which is essential for the

catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating

the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to

dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which

implicated the role of this PTP in cell growth control, and cell response to interferon

stimulation. [provided by RefSeq]

UniProtKB/Swiss-Prot: PTN1_HUMAN, P18031

Function: May play an important role in CKII- and p60c-src-induced signal transduction cascades (By

similarity)

Gene Wiki entry for PTPN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PTPN1 gene

Entrez Gene cytogenetic band: 20q13.1-q13.2 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.1-q13.2

PTPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P048560: (about GC identifiers)

Start:	48,560,298 bp from pter
End:	48,634,495 bp from pter
Size:	74,198 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PTN1_HUMAN, P18031 (See protein sequence)

Recommended Name: Tyrosine-protein phosphatase non-receptor type 1

Size: 435 amino acids; 49967 Da

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side

PDB structures from and Proteopedia :

1A5Y (3D)

1AAX (3D)

1BZC (3D)

1BZH (3D)

1BZJ (3D)

1C83 (3D)

1C84 (3D)

1C85 (3D)

1C86 (3D)

1C87 (3D)

1C88 (3D)

1ECV (3D)

1EEN (3D)

1EEO (3D)

1G1F (3D)

1G1G (3D)

1G1H (3D)

1G7F (3D)

1G7G (3D)

1GFY (3D)

1I57 (3D)

1JF7 (3D)

1KAK (3D)

1KAV (3D)

1L8G (3D)

1LQF (3D)

1NL9 (3D)

1NNY (3D)

1NO6 (3D)

1NWE (3D)

1NWL (3D)

1NZ7 (3D)

1OEM (3D)

1OEO (3D)

1OES (3D)

1OET (3D)

1OEU (3D)

1OEV (3D)

1ONY (3D)

1ONZ (3D)

1PA1 (3D)

1PH0 (3D)

1PTT (3D)

1PTU (3D)

1PTV (3D)

1PTY (3D)

1PXH (3D)

1PYN (3D)

1Q1M (3D)

1Q6J (3D)

1Q6M (3D)

1Q6N (3D)

1Q6P (3D)

1Q6S (3D)

1Q6T (3D)

1QXK (3D)

1SUG (3D)

1T48 (3D)

1T49 (3D)

1T4J (3D)

1WAX (3D)

1XBO (3D)

2AZR (3D)

2B07 (3D)

2B4S (3D)

2BGD (3D)

2BGE (3D)

2CM2 (3D)

2CM3 (3D)

2CM7 (3D)

2CM8 (3D)

2CMA (3D)

2CMB (3D)

2CMC (3D)

2CNE (3D)

2CNF (3D)

2CNG (3D)

2CNH (3D)

2CNI (3D)

2F6F (3D)

2F6T (3D)

2F6V (3D)

2F6W (3D)

2F6Y (3D)

2F6Z (3D)

2F70 (3D)

2F71 (3D)

2FJM (3D)

2FJN (3D)

2H4G (3D)

2H4K (3D)

2HB1 (3D)

2HNP (3D)

2HNQ (3D)

2NT7 (3D)

2NTA (3D)

2QBP (3D)

2QBQ (3D)

2QBR (3D)

2QBS (3D)

2VEU (3D)

2VEV (3D)

2VEW (3D)

2VEX (3D)

2VEY (3D)

2ZMM (3D)

2ZN7 (3D)

3CWE (3D)

3D9C (3D)

3EU0 (3D)

Secondary accessions: Q5TGD8 Q9BQV9 Q9NQQ4

Post-translational modifications:

Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido

of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a

conformational change that inhibits substrate binding and activity. The active site can be

restored by reduction¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002818.1

ENSEMBL proteins:

ENSP00000360683

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant PTPN1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for PTPN1 (PTP1B)
	Enzo Life Sciences proteins for PTPN1
	Recombinant Proteins from Abcam (PTP1B)
	Human Recombinant Proteins from Abnova (PTPN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for PTPN1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PTPN1
	Sigma-Aldrich Antibodies for PTPN1
	R&D Systems Antibodies for PTPN1 (PTP1B)
	Antibodies from Abcam (PTP1B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PTPN1)
	Novus Biologicals Antibodies for PTPN1

Assays for PTPN1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of PTPN1
	R&D Systems ELISAs for PTPN1 (PTP1B) (see all)
	Enzo Life Sciences assays for PTPN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18031

ProtoNet protein and cluster: P18031

1 Blocks protein family: IPB000242 Protein tyrosine phosphatase signature

UniProtKB/Swiss-Prot: PTN1_HUMAN, P18031

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTPN1)
		Millipore RNAi Products for the Analysis of PTPN1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PTPN1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002827

Applied Biosystems Silencer® siRNAs for PTPN1

Sigma-Aldrich siRNA and siRNA Panels for PTPN1

Sigma-Aldrich shRNA Panels and shRNA for PTPN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PTPN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002827
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002827
untagged cDNA clone in CMV expression vector: NM_002827

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002827

UniProtKB/Swiss-Prot: PTN1_HUMAN, P18031

Function: May play an important role in CKII- and p60c-src-induced signal transduction cascades (By

similarity)

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Enzyme Number (IUBMB): EC 3.1.3.48

Genatlas biochemistry entry for PTPN1:

protein tyrosine phosphatase,non receptor type 1

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ptpn1):

adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	life span-post-weaning/aging	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	IDA	18074158
GO:0005515	protein binding	IPI	11106648 12907755 16291744 17159996
GO:0008270	zinc ion binding	IDA	18074158
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for PTPN1 (Your Favorite Gene powered by Ingenuity)

JAK/Stat Signaling
Caveolar-mediated Endocytosis
Insulin Receptor Signaling

GeneDecks PTPN1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PTPN1

5/137 Interacting proteins for PTPN1 (P18031^{1, 2} ENSP00000360683³) via UniProtKB, MINT, and/or STRING (see all 137 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRC	P12931², ENSP00000362659³	MINT-6797096 MINT-6793501 MINT-6794959 MINT-6795286 MINT-6794163 MINT-6795447 MINT-6764626 MINT-6764915 MINT-6795268 MINT-6795409 MINT-6795229 MINT-6794843 MINT-6794810 MINT-6795255 STRING (score=.999)
TRPV6	Q9H1D0², ENSP00000352358³	MINT-6765232 MINT-6765208 MINT-6764676 MINT-6764665 MINT-6764687 MINT-6765197 STRING (score=.998)
BCAR1	P56945², ENSP00000162330³	MINT-6793484 MINT-6793467 MINT-6762444 MINT-6764626 MINT-6793403 STRING (score=.999)
CAV1	Q03135², ENSP00000339191³	MINT-6793807 MINT-6793849 MINT-6764881 MINT-6764852 MINT-6764866 STRING (score=.988)
EGFR	P00533², ENSP00000275493³	MINT-6762409 MINT-6793358 MINT-6793373 MINT-6762370 STRING (score=.999)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006470	protein amino acid dephosphorylation	IEA	--
GO:0007165	signal transduction	TAS	10748206
GO:0046627	negative regulation of insulin receptor signaling pathway	NAS	11742412

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PTPN1

Sigma-Aldrich Small Molecules for PTPN1:

Inhibitor

Compounds for PTPN1 available from Tocris Bioscience

Compound	Action	CAS number
TCS 401	Selective inhibitor of PTP1B	[243967-42-2]

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10/53 Novoseek chemical compound relationships for PTPN1 gene (see all 53 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	88.28	778	11506178 (8), 9407132 (5), 11136729 (4), 16271887 (4) (see all 99)
2-(oxalyl-amino)-benzoic acid	85.63	7	10702277 (2), 16230012 (2), 12697028 (1)
phosphotyrosine	84.29	62	9922143 (4), 10889023 (2), 11341829 (2), 9756867 (2) (see all 38)
raytide	75.14	1	8494789 (1)
1,2-naphthoquinone	66.92	13	17878162 (5), 15727882 (2), 18057784 (2)
p-nitrophenyl phosphate	64.71	8	12748196 (2), 15924436 (1), 17762161 (1), 10660596 (1) (see all 6)
vanadate	58.46	4	9050838 (1), 17655273 (1), 15171692 (1), 16360107 (1)
pyridazine	52.37	8	12150865 (2), 17140831 (2), 15012988 (2)
benzofuran	50.52	6	10753467 (2), 11983524 (1), 15537353 (1)
tyrosine sulfate	49.84	2	10593610 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTPN1)
		Millipore RNAi Products for the Analysis of PTPN1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PTPN1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002827

Sigma-Aldrich siRNA and siRNA Panels for PTPN1

Sigma-Aldrich shRNA Panels and shRNA for PTPN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002827

REFSEQ mRNAs for PTPN1 gene:

NM_002827.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002827

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002827
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002827
                                 untagged cDNA clone in CMV expression vector: NM_002827

Additional cDNA sequence:

AK290638.1 AK299830.1 AK316563.1 BC015660.2 BC018164.1 BT006752.1 CR597778.1 M31724.1

M33689.1

9 DOTS entries:

DT.100787381 DT.216658 DT.40280527 DT.305645 DT.95079713 DT.95171755 DT.91838226 DT.97806001

DT.99944514

24/267 AceView cDNA sequences (see all 267 ):

CD368023 CR597778 BG680937 CB112528 AI611145 AI347117 CA428085 AI096725

AA252649 AW007014 AI498509 BM905219 AL558741 AA987294 BE672300 CB143249

BU193045 BQ130674 AU138481 BU785894 BF795407 CB150520 BG150160 CA309848

highest scoring ESTs for PTPN1:

M31724 AA005020 AA029531 AA036759 AA193493 AA193539 AA243361 AA252649 AA258652 AA381416

Unigene Cluster for PTPN1:

Protein tyrosine phosphatase, non-receptor type 1

Hs.417549 [show with all ESTs]

Unigene Representative Sequence: NM_002827

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000371621

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PTPN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PTPN1

¹ / ² / ³

5 probe-sets matching PTPN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
588_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.11	M31724	1.00	0.90	0.95	1
591_s_at²^{, 3}	U95-A	1	1.00	1.00	0.55	0.85	M33684	0.20	1.00	0.72	1
40137_at²^{, 3}	U95-A	1	0.81	1.00	0.96	1.04	M31724	1.00	0.90	0.95	1
202716_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002827	0.60	1.00	0.82	1
202716_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PTPN1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAATAAACCA

SOURCE GeneReport for Unigene cluster: Hs.417549
Expression variation in blood from EXPOLDB for PTPN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PTPN1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PTPN1¹	--	protein tyrosine phosphatase, non-receptor type 1	89.28(n) 90.78(a)	477263 XM_534455.2 XP_534455.2
chimpanzee (Pan troglodytes)	PTPN1¹	--	protein tyrosine phosphatase, non-receptor type 1	99.77(n) 100(a)	469970 XM_525354.2 XP_525354.2
cow (Bos taurus)	PTPN1¹	--	protein tyrosine phosphatase, non-receptor type 1	87.39(n) 89.83(a)	508658 XM_585466.3 XP_585466.3
rat (Rattus norvegicus)	Ptpn1¹	--	protein tyrosine phosphatase, non-receptor type 1	81.59(n) 85.38(a)	24697 NM_012637.1 NP_036769.1
mouse (Mus musculus)	Ptpn1^{1, 5}	2⁵	protein tyrosine phosphatase, non-receptor type 1^{1, 5}	81.44(n)¹ 83.76(a)¹	19246¹ NM_011201.3¹ NP_035331.3¹ AA386743⁵ AK085713⁵ (see all 46)

About this table Species with no ortholog for PTPN1

ENSEMBL Gene Tree for PTPN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PTPN1 gene

PTPRN² PTPRN2² PTPN2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/389 NCBI SNPs in PTPN1 are shown (see all 389 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 163)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs16995304^1,2	C,F,H	48631261(+)	`TTCGAG/AGTGCC`	1	S/G	mis¹		5		EU EA WA	1632
	rs1057207^1,2	C,F	48634577(+)	`TGGGTG/TGGGGG`	1	--	ng3¹		1		MN	184
	rs6096014^1,2	F,H	48633765(+)	`CCTCAC/TGCTCT`	1	--	ut3¹ ese³		4		EU EA WA	416
	rs16995309^1,2	C,F	48631280(+)	`CTCCCC/TAGCCA`	1	P/L	mis¹ ese³		1		EU	1226
--	rs6126029^1,2	A,C	48559304(+)	`tgatcA/Cacctg`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs13036899^1,2	H	48634593(+)	`TCTCAG/AGGTCT`	1	--	ng3¹ ese³		4		EU EA WA	414
--	rs16995311^1,2	F	48634509(+)	`AAAAAA/CAGCAA`	1	--	ng3¹		1		EU	1226
--	rs16989673^1,2	F	48632763(+)	`CCGCG-/GTAGAG`	1	--	ut3¹		1		EU	1226
	rs6067490^1,2	H	48633727(+)	`ACTCAG/AACATT`	1	--	ut3¹ ese³		4		EU EA WA	414
--	rs4140567^1,2	C	48560146(-)	`CCGCTC/TTGGGG`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for PTPN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 176885 disorders: 125853

10/24 Novoseek disease relationships for PTPN1 gene (see all 24 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	61.01	111	18846048 (3), 15640130 (3), 12556216 (3), 10444024 (3) (see all 59)
insulin resistance	59.33	53	11833006 (4), 15031294 (4), 17560463 (3), 9322796 (2) (see all 24)
insulin sensitivity	54.86	29	15919835 (2), 11703427 (2), 14976221 (2), 16249458 (2) (see all 18)
bubonic plague	50.95	1	15781408 (1)
niddm	34.65	11	10444024 (2), 15470600 (1), 15715684 (1), 12678843 (1) (see all 8)
metabolic disorder	12.66	1	16677372 (1)
necrosis	3.96	3	10023672 (1), 17605309 (1)
tumors	3.48	21	7905928 (4), 8640675 (2), 16267035 (2), 10023672 (1) (see all 11)
alzheimers disease	3.27	1	7812792 (1)
inflammation	1.33	1	18236007 (1)

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Human Gene Mutation Database: PTPN1
Genetic Association Database: PTPN1
Human Genome Epidemiology Navigator: PTPN1 (22 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/490 PubMed articles for PTPN1 gene (see all 490 ):

Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism. (PubMed id 15919835)^{1, 3, 4, 6} Ukkola O.... Bouchard C. (2005)
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. (PubMed id 2164224)^{2, 3, 4} Brown-Shimer S.... Hill D.E. (1990)
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. (PubMed id 11579209)^{1, 3, 4} Ravichandran L.V.... Quon M.J. (2001)
Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation. (PubMed id 8491187)^{1, 3, 4} Flint A.J.... Tonks N.K. (1993)
Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study. (PubMed id 15504985)^{1, 3, 6} Palmer N.D....Bowden D.W. (2004)
A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro. (PubMed id 11756316)^{1, 3, 6} Echwald S.M....Pedersen O. (2002)
Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. (PubMed id 9922143)^{1, 3, 4} Groves M.R.... Barford D. (1998)
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. (PubMed id 12802338)^{1, 3, 4} Salmeen A.... Barford D. (2003)
Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population. (PubMed id 16249458)^{1, 3, 6} Spencer-Jones N.J....O'Dell S.D. (2005)
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. (PubMed id 15097232)^{1, 3, 6} Speirs H.J....Morris B.J. (2004)

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Entrez Gene: 5770	HGNC: 9642	AceView: PTPN1	Ensembl:ENSG00000196396	euGenes: HUgn5770
ECgene: PTPN1	H-InvDB: PTPN1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
ATLAS Chromosomes in Cancer entry for PTPN1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PTPN1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Products for PTPN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
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Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PTPN1-related products

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Antibodies for PTPN1

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PTPN1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for PTPN1

Summaries
for PTPN1

Genomic Location
for PTPN1

Proteins
for PTPN1

Protein Domains/
Families
for PTPN1

Gene Function
for PTPN1

Pathways & Interactions
for PTPN1

Drugs & Compounds
for PTPN1

Transcripts
for PTPN1

Expression
for PTPN1

Orthologs
for PTPN1

Paralogs
for PTPN1

SNPs/Variants
for PTPN1

Disorders & Mutations
for PTPN1

Medical News
for PTPN1

Publications
for PTPN1

Search for PTPN1

Genome Databases showing PTPN1

Other Databases showing PTPN1

Specialized Databases showing PTPN1

Licensable Technologies
for PTPN1

Services
for PTPN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PTPN1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor PTPN1

Summariesfor PTPN1

Genomic Locationfor PTPN1

Proteinsfor PTPN1

Protein Domains/Familiesfor PTPN1

Gene Functionfor PTPN1

Pathways & Interactionsfor PTPN1

Drugs & Compoundsfor PTPN1

Transcriptsfor PTPN1

Expression for PTPN1

Orthologsfor PTPN1

Paralogsfor PTPN1

SNPs/Variantsfor PTPN1

Disorders & Mutationsfor PTPN1

Medical Newsfor PTPN1

Publicationsfor PTPN1

Search for PTPN1

Genome Databases showing PTPN1

Other Databases showing PTPN1

Specialized Databases showing PTPN1

Licensable Technologiesfor PTPN1

Servicesfor PTPN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PTPN1

Summaries
for PTPN1

Genomic Location
for PTPN1

Proteins
for PTPN1

Protein Domains/
Families
for PTPN1

Gene Function
for PTPN1

Pathways & Interactions
for PTPN1

Drugs & Compounds
for PTPN1

Transcripts
for PTPN1

Expression
for PTPN1

Orthologs
for PTPN1

Paralogs
for PTPN1

SNPs/Variants
for PTPN1

Disorders & Mutations
for PTPN1

Medical News
for PTPN1

Publications
for PTPN1

Licensable Technologies
for PTPN1

Services
for PTPN1