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Aliases for PTPN1 Gene

Aliases for PTPN1 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 2 3
  • PTP1B 3 4 6
  • Protein-Tyrosine Phosphatase 1B 3 4
  • EC 3.1.3.48 4 64
  • Tyrosine-Protein Phosphatase Non-Receptor Type 1 3
  • Protein Tyrosine Phosphatase, Placental 3
  • PTP-1B 4

External Ids for PTPN1 Gene

Previous Symbols for PTPN1 Gene

  • PTP1B

Summaries for PTPN1 Gene

Entrez Gene Summary for PTPN1 Gene

  • The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTPN1 Gene

PTPN1 (Protein Tyrosine Phosphatase, Non-Receptor Type 1) is a Protein Coding gene. Diseases associated with PTPN1 include bubonic plague and plague. Among its related pathways are Signaling by GPCR and PAK Pathway. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN6.

UniProtKB/Swiss-Prot for PTPN1 Gene

  • Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Tocris Summary for PTPN1 Gene

  • Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. PTPs are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity. PTPs are currently divided into five subtypes; tyrosine-specific phosphatases (e.g. PTP1B), dual specificity phosphatases (DSPs) (e.g. DUSP1), Cdc25 phosphatases (e.g. Cdc25A), myotubularin-related phosphatases (e.g. MTMR13) and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity has been implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator of the insulin signaling by dephosphorylating phosphotyrosine residues of insulin receptor kinase. In cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Gene Wiki entry for PTPN1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN1 Gene

Genomics for PTPN1 Gene

Genomic Location for PTPN1 Gene

Start:
50,510,321 bp from pter
End:
50,585,241 bp from pter
Size:
74,921 bases
Orientation:
Plus strand

Genomic View for PTPN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN1 Gene

Regulatory Elements for PTPN1 Gene

Proteins for PTPN1 Gene

  • Protein details for PTPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18031-PTN1_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 1
    Protein Accession:
    P18031
    Secondary Accessions:
    • Q5TGD8
    • Q9BQV9
    • Q9NQQ4

    Protein attributes for PTPN1 Gene

    Size:
    435 amino acids
    Molecular mass:
    49967 Da
    Quaternary structure:
    • Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for PTPN1 Gene

neXtProt entry for PTPN1 Gene

Proteomics data for PTPN1 Gene at MOPED

Post-translational modifications for PTPN1 Gene

  • Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
  • S-nitrosylation of Cys-215 inactivates the enzyme activity.
  • Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.
  • Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PTPN1 Gene

Gene Families for PTPN1 Gene

HGNC:
  • PTPN :Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor

UniProtKB/Swiss-Prot:

PTN1_HUMAN
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.:
    • P18031
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.:
    • P18031
genes like me logo Genes that share domains with PTPN1: view

Function for PTPN1 Gene

Molecular function for PTPN1 Gene

GENATLAS Biochemistry: protein tyrosine phosphatase,non receptor type 1
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Enzyme Numbers (IUBMB) for PTPN1 Gene

Gene Ontology (GO) - Molecular Function for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity TAS --
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 10660596
GO:0008270 zinc ion binding IDA 18074158
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTPN1: view
genes like me logo Genes that share phenotypes with PTPN1: view

Animal Models for PTPN1 Gene

MGI Knock Outs for PTPN1:

No data available for Transcription Factor Targeting and HOMER Transcription for PTPN1 Gene

Localization for PTPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interacts with EPHA3 at the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPN1 Gene COMPARTMENTS Subcellular localization image for PTPN1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
cytosol 4
nucleus 2
plasma membrane 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 21135139
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA 21135139
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PTPN1: view

Pathways for PTPN1 Gene

genes like me logo Genes that share pathways with PTPN1: view

Interacting Proteins for PTPN1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360683%0d%0a9606.ENSP00000350941%0d%0a9606.ENSP00000303830%0d%0a9606.ENSP00000391669%0d%0a9606.ENSP00000275493%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: P18031-PTN1_HUMAN ENSP00000360683 for PTPN1 Gene via MINT STRING UniProtKB I2D

Symbol External ID(s) Details
INSR
SRC
GHR
TRPV6
BCAR1

Gene Ontology (GO) - Biological Process for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IMP 22045810
GO:0006987 activation of signaling protein activity involved in unfolded protein response TAS 22013210
GO:0007596 blood coagulation TAS --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0009966 regulation of signal transduction IMP 21135139
genes like me logo Genes that share ontologies with PTPN1: view

Compounds for PTPN1 Gene

(5) Tocris Compounds for PTPN1 Gene

Compound Action Cas Number
Alexidine dihydrochloride Selective inhibitor of PTPMT1 [1715-30-6]
BVT 948 Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling [39674-97-0]
NSC 87877 Potent inhibitor of shp2 and shp1 PTP [56990-57-9]
Sodium orthovanadate Protein tyrosine phosphatase inhibitor [13721-39-6]
TCS 401 Selective inhibitor of PTP1B [243967-42-2]

(2) HMDB Compounds for PTPN1 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(73) Novoseek inferred chemical compound relationships for PTPN1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 88.6 240
2-(oxalyl-amino)-benzoic acid 85 5
phosphotyrosine 83.4 47
raytide 74.3 1
1,2-naphthoquinone 65.2 9
genes like me logo Genes that share compounds with PTPN1: view

Transcripts for PTPN1 Gene

mRNA/cDNA for PTPN1 Gene

Unigene Clusters for PTPN1 Gene

Protein tyrosine phosphatase, non-receptor type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN1 Gene

No ASD Table

Relevant External Links for PTPN1 Gene

GeneLoc Exon Structure for
PTPN1
ECgene alternative splicing isoforms for
PTPN1

Expression for PTPN1 Gene

mRNA expression in normal human tissues for PTPN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPN1 Gene

SOURCE GeneReport for Unigene cluster for PTPN1 Gene Hs.417549

genes like me logo Genes that share expressions with PTPN1: view

Orthologs for PTPN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN1 36
  • 99.77 (n)
  • 100 (a)
PTPN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPN1 36
  • 87 (n)
  • 89.6 (a)
PTPN1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN1 36
  • 89.67 (n)
  • 91.08 (a)
PTPN1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpn1 36
  • 81.44 (n)
  • 83.76 (a)
Ptpn1 16
Ptpn1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPN1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn1 36
  • 81.59 (n)
  • 85.38 (a)
chicken
(Gallus gallus)
Aves PTPN1 36
  • 73.4 (n)
  • 79.81 (a)
PTPN1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN1 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15249 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn1 36
  • 69.56 (n)
  • 73.24 (a)
Str.7557 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10706 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
ptpn1 36
  • 63.53 (n)
  • 68.36 (a)
ptpn1 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ptp61F 37
  • 30 (a)
OneToMany
Ptp61F 38
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea C55B7.3 38
  • 31 (a)
T22C1.8 38
  • 32 (a)
F10G8.1 38
  • 32 (a)
ZK484.7 38
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for PTPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN1 Gene

ENSEMBL:
Gene Tree for PTPN1 (if available)
TreeFam:
Gene Tree for PTPN1 (if available)

Paralogs for PTPN1 Gene

genes like me logo Genes that share paralogs with PTPN1: view

Variants for PTPN1 Gene

Sequence variations from dbSNP and Humsavar for PTPN1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs718049 -- 50,580,062(+) CAGGG(C/T)GCGTG intron-variant
rs718050 -- 50,580,393(+) TACCT(A/G)TTGAT intron-variant
rs718051 -- 50,580,220(+) TGCCC(C/T)CCCTG intron-variant
rs718052 -- 50,580,222(+) CCCCC(C/G)CTGAC intron-variant
rs718053 -- 50,580,065(+) GGCGC(A/G)TGGAC intron-variant

Relevant External Links for PTPN1 Gene

HapMap Linkage Disequilibrium report
PTPN1
Human Gene Mutation Database (HGMD)
PTPN1

No data available for Structural Variations from Database of Genomic Variants (DGV) for PTPN1 Gene

Disorders for PTPN1 Gene

(1) OMIM Diseases for PTPN1 Gene (176885)

(1) University of Copenhagen DISEASES for PTPN1 Gene

(24) Novoseek inferred disease relationships for PTPN1 Gene

Disease -log(P) Hits PubMed IDs
obesity 62.2 79
insulin resistance 60.7 49
insulin sensitivity 55.7 24
bubonic plague 49.2 1
niddm 31.9 9

Relevant External Links for PTPN1

Genetic Association Database (GAD)
PTPN1
Human Genome Epidemiology (HuGE) Navigator
PTPN1
genes like me logo Genes that share disorders with PTPN1: view

No data available for UniProtKB/Swiss-Prot for PTPN1 Gene

Publications for PTPN1 Gene

  1. Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism. (PMID: 15919835) Ukkola O. … Bouchard C. (Obes. Res. 2005) 3 4 23 49
  2. Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects. (PMID: 15235769) Kipfer-Coudreau S. … ClAcment K. (Diabetologia 2004) 3 23 49
  3. Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study. (PMID: 15504985) Palmer N.D. … Bowden D.W. (Diabetes 2004) 3 23 49
  4. The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population. (PMID: 15715684) Gouni-Berthold I. … Krone W. (J. Intern. Med. 2005) 3 23 49
  5. Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. (PMID: 16677372) Cheyssac C. … Vaxillaire M. (BMC Med. Genet. 2006) 3 23 49

Products for PTPN1 Gene

  • Addgene plasmids for PTPN1

Sources for PTPN1 Gene

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