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Aliases for PTPMT1 Gene

Aliases for PTPMT1 Gene

  • Protein Tyrosine Phosphatase, Mitochondrial 1 2 3
  • Protein-Tyrosine Phosphatase Mitochondrial 1 3 4
  • Phosphoinositide Lipid Phosphatase 3 4
  • PTEN-Like Phosphatase 3 4
  • MOSP 3 4
  • PLIP 3 4
  • NB4 Apoptosis/Differentiation Related Protein 3
  • EC 3.1.3.27 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • PNAS-129 3
  • DUSP23 3

External Ids for PTPMT1 Gene

Previous GeneCards Identifiers for PTPMT1 Gene

  • GC11P047532
  • GC11U900934
  • GC11P047287

Summaries for PTPMT1 Gene

GeneCards Summary for PTPMT1 Gene

PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1) is a Protein Coding gene. Diseases associated with PTPMT1 include cogan syndrome. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for PTPMT1 Gene

  • Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPMT1 Gene

Genomics for PTPMT1 Gene

Regulatory Elements for PTPMT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTPMT1 Gene

Chromosome:
11
Start:
47,565,430 bp from pter
End:
47,573,461 bp from pter
Size:
8,032 bases
Orientation:
Plus strand

Genomic View for PTPMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PTPMT1 Gene

Proteins for PTPMT1 Gene

  • Protein details for PTPMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUK0-PTPM1_HUMAN
    Recommended name:
    Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
    Protein Accession:
    Q8WUK0
    Secondary Accessions:
    • E9PAT8
    • Q7Z557
    • Q96CR2
    • Q9BXV8

    Protein attributes for PTPMT1 Gene

    Size:
    201 amino acids
    Molecular mass:
    22844 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07545.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PTPMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPMT1 Gene

Proteomics data for PTPMT1 Gene at MOPED

Post-translational modifications for PTPMT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPMT1 Gene

Antibody Products

No data available for DME Specific Peptides for PTPMT1 Gene

Domains & Families for PTPMT1 Gene

Suggested Antigen Peptide Sequences for PTPMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUK0

UniProtKB/Swiss-Prot:

PTPM1_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with PTPMT1: view

Function for PTPMT1 Gene

Molecular function for PTPMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).

Enzyme Numbers (IUBMB) for PTPMT1 Gene

Gene Ontology (GO) - Molecular Function for PTPMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0008962 phosphatidylglycerophosphatase activity ISS --
genes like me logo Genes that share ontologies with PTPMT1: view
genes like me logo Genes that share phenotypes with PTPMT1: view

Animal Models for PTPMT1 Gene

MGI Knock Outs for PTPMT1:

Animal Model Products

miRNA for PTPMT1 Gene

No data available for Transcription Factor Targets and HOMER Transcription for PTPMT1 Gene

Localization for PTPMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPMT1 Gene

Mitochondrion inner membrane. Note=Associated with the inner membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTPMT1 Gene COMPARTMENTS Subcellular localization image for PTPMT1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PTPMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IBA --
GO:0031305 integral component of mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with PTPMT1: view

Pathways & Interactions for PTPMT1 Gene

genes like me logo Genes that share pathways with PTPMT1: view

UniProtKB/Swiss-Prot Q8WUK0-PTPM1_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2

Gene Ontology (GO) - Biological Process for PTPMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006655 phosphatidylglycerol biosynthetic process TAS --
GO:0016311 dephosphorylation --
GO:0032049 cardiolipin biosynthetic process ISS --
genes like me logo Genes that share ontologies with PTPMT1: view

No data available for SIGNOR curated interactions for PTPMT1 Gene

Drugs & Compounds for PTPMT1 Gene

(2) Drugs for PTPMT1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420
tyrosine Nutra 547

(6) Additional Compounds for PTPMT1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
LIPID
genes like me logo Genes that share compounds with PTPMT1: view

Transcripts for PTPMT1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PTPMT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8: -
SP9:
SP10: -

Relevant External Links for PTPMT1 Gene

GeneLoc Exon Structure for
PTPMT1
ECgene alternative splicing isoforms for
PTPMT1

Expression for PTPMT1 Gene

mRNA expression in normal human tissues for PTPMT1 Gene

Protein differential expression in normal tissues from HIPED for PTPMT1 Gene

This gene is overexpressed in Bone (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTPMT1 Gene



SOURCE GeneReport for Unigene cluster for PTPMT1 Gene Hs.656205

genes like me logo Genes that share expression patterns with PTPMT1: view

Protein tissue co-expression partners for PTPMT1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTPMT1 Gene

Orthologs for PTPMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTPMT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPMT1 35
  • 86.98 (n)
  • 83.33 (a)
PTPMT1 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPMT1 35
  • 90.82 (n)
  • 88.27 (a)
PTPMT1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptpmt1 35
  • 87.05 (n)
  • 84.46 (a)
Ptpmt1 16
chimpanzee
(Pan troglodytes)
Mammalia PTPMT1 35
  • 99.67 (n)
  • 99.5 (a)
PTPMT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpmt1 35
  • 86.7 (n)
  • 84.46 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPMT1 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPMT1 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPMT1 35
  • 69.47 (n)
  • 65.79 (a)
PTPMT1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPMT1 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptpmt1 35
  • 59.7 (n)
  • 57.06 (a)
ptpmt1 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000617 35
  • 56 (n)
  • 46.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Plip 35
  • 56.98 (n)
  • 45.93 (a)
Plip 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F28C6.8 35
  • 45.54 (n)
  • 37.16 (a)
F28C6.8 36
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G56610 35
  • 46.78 (n)
  • 40.91 (a)
rice
(Oryza sativa)
Liliopsida Os05g0524200 35
  • 49.43 (n)
  • 41.95 (a)
Species with no ortholog for PTPMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPMT1 Gene

ENSEMBL:
Gene Tree for PTPMT1 (if available)
TreeFam:
Gene Tree for PTPMT1 (if available)

Paralogs for PTPMT1 Gene

No data available for Paralogs for PTPMT1 Gene

Variants for PTPMT1 Gene

Sequence variations from dbSNP and Humsavar for PTPMT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3740655 -- 47,569,801(+) GCTCT(C/T)AAGTA intron-variant, reference, synonymous-codon
rs7945473 -- 47,568,155(+) gacct(C/T)gtgat intron-variant
rs11039301 -- 47,568,636(+) atgat(C/T)gcata intron-variant
rs12786767 -- 47,569,008(+) TAAGA(C/T)GTTTG intron-variant
rs12786958 -- 47,569,006(+) GTTAA(G/T)ACGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTPMT1 Gene

Variant ID Type Subtype PubMed ID
nsv897325 CNV Loss 21882294
nsv832142 CNV Loss 17160897
nsv314 CNV Loss 18451855
nsv825872 CNV Gain 20364138
nsv509405 CNV Insertion 20534489

Variation tolerance for PTPMT1 Gene

Residual Variation Intolerance Score: 74.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTPMT1 Gene

HapMap Linkage Disequilibrium report
PTPMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPMT1 Gene

Disorders for PTPMT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTPMT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cogan syndrome
  • diffuse interstitual keratitis
- elite association

Relevant External Links for PTPMT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTPMT1
genes like me logo Genes that share disorders with PTPMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPMT1 Gene

Publications for PTPMT1 Gene

  1. Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*. (PMID: 18377662) Bhattacharya R. … Mukhopadhyay D. (J Mol Signal 2008) 23 67
  2. Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins. (PMID: 17142110) Tortorella C. … Antonaci S. (Ageing Res. Rev. 2007) 23 67
  3. Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. (PMID: 17540846) Cheng J. … Marasco W.A. (Blood 2007) 23 67
  4. Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. (PMID: 16501054) Fortin C.F. … Fulop T. (J. Leukoc. Biol. 2006) 23 67
  5. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. (PMID: 16039589) Pagliarini D.J. … Dixon J.E. (Mol. Cell 2005) 23 67

Products for PTPMT1 Gene

Sources for PTPMT1 Gene

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