Aliases for PTPMT1 Gene
External Ids for PTPMT1 Gene
GeneCards Summary for PTPMT1 Gene
PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1) is a Protein Coding gene. Diseases associated with PTPMT1 include stomach cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein tyrosine phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.
UniProtKB/Swiss-Prot for PTPMT1 Gene
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).