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PTPMT1 Gene

protein-coding   GIFtS: 55
GCID: GC11P047586

Protein Tyrosine Phosphatase, Mitochondrial 1

  See PTPMT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase, Mitochondrial 11 2     DUSP232
Phosphoinositide Lipid Phosphatase2 3     NB4 Apoptosis/Differentiation Related Protein2
Protein-Tyrosine Phosphatase Mitochondrial 12 3     Phosphatidylglycerophosphatase And Protein-Tyrosine Phosphatase 12
MOSP2 3     EC 3.1.3.163
PLIP2 3     EC 3.1.3.273
PTEN-Like Phosphatase2 3     EC 3.1.3.483

External Ids:    HGNC: 269651   Entrez Gene: 1149712   Ensembl: ENSG000001105367   OMIM: 6095385   UniProtKB: Q8WUK03   

Export aliases for PTPMT1 gene to outside databases

Previous GC identifers: GC11P047532 GC11U900934 GC11P047287


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PTPMT1 Gene:
PTPMT1 (protein tyrosine phosphatase, mitochondrial 1) is a protein-coding gene. Diseases associated with PTPMT1 include cogan's syndrome, and stomach cancer. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity and protein tyrosine phosphatase activity.

UniProtKB/Swiss-Prot: PTPM1_HUMAN, Q8WUK0
Function: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol
(PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific
phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display
phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial
proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins
phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved
in regulation of insulin secretion in pancreatic beta cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTPMT1 gene promoter:
         MEF-2A   C/EBPbeta   AP-1   ATF-2   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPMT1 promoter sequence
   Search Chromatin IP Primers for PTPMT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTPMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

PTPMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPMT1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P047586:  view genomic region     (about GC identifiers)

Start:
47,586,982 bp from pter      End:
47,595,013 bp from pter
Size:
8,032 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTPM1_HUMAN, Q8WUK0 (See protein sequence)
Recommended Name: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 precursor  
Size: 201 amino acids; 22844 Da
Caution: Was originally erroneously termed DUSP23
Sequence caution: Sequence=AAH14048.1; Type=Erroneous initiation; Sequence=AAK07545.1; Type=Erroneous initiation;
Secondary accessions: E9PAT8 Q7Z557 Q96CR2 Q9BXV8
Alternative splicing: 3 isoforms:  Q8WUK0-1   Q8WUK0-2   Q8WUK0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTPMT1: NX_Q8WUK0

Explore proteomics data for PTPMT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PTPMT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137456.1  NP_783859.1  

    ENSEMBL proteins: 
     ENSP00000410272   ENSP00000436160   ENSP00000325882   ENSP00000325958  
    Reactome Protein details: Q8WUK0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    4 InterPro protein domains:
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP
     IPR000387 Tyr/Dual-sp_Pase
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q8WUK0

    ProtoNet protein and cluster: Q8WUK0

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: PTPM1_HUMAN, Q8WUK0
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTPMT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTPM1_HUMAN, Q8WUK0
    Function: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol
    (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific
    phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display
    phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial
    proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins
    phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved
    in regulation of insulin secretion in pancreatic beta cells (By similarity)
    Catalytic activity: Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.271 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA--
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
    GO:0008962phosphatidylglycerophosphatase activity ISS--
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTPMT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PTPMT1:
     Decreased TP53 protein express 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ptpmt1):
     cellular  embryogenesis  growth/size/body  hematopoietic system  immune system 
     mortality/aging 

    Find genes that share phenotypes with PTPMT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTPMT1: Ptpmt1tm1Ckq Ptpmt1tm1.2Jedi

       genOway: Develop your customized and physiologically relevant rodent model for PTPMT1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTPM1_HUMAN, Q8WUK0: Mitochondrion inner membrane (By similarity). Note=Associated with the inner membrane (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IBA--
    GO:0005743mitochondrial inner membrane IEA--

    Find genes that share ontologies with PTPMT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTPMT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PG0.00
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with PTPMT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PTPMT1
        Synthesis of PG


    UniProtKB/Swiss-Prot: PTPM1_HUMAN, Q8WUK0
    Pathway: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol:
    step 2/2

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTPMT1
    Interactions:

        Search GeneGlobe Interaction Network for PTPMT1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for PTPMT1 (Q8WUK02, 3 ENSP000003259584) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3, ENSP000002161604MINT-8260306 I2D: score=2 STRING: ENSP00000216160
    MAPK6Q166592, 3MINT-8261780 I2D: score=2 
    MDFIQ997503I2D: score=1 
    TMEM55BENSP000003811024STRING: ENSP00000381102
    TMEM55AENSP000002854194STRING: ENSP00000285419
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IBA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006655phosphatidylglycerol biosynthetic process TAS--
    GO:0016311dephosphorylation ----
    GO:0032049cardiolipin biosynthetic process ISS--

    Find genes that share ontologies with PTPMT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PTPMT1 (PTPM1)

    3 HMDB Compounds for PTPMT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for PTPMT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 58.6 23 11907074 (2), 12879010 (2), 7718049 (1), 9544992 (1) (see all 15)
    phosphoinositide 36.3 1 17142110 (1)
    serine 31.4 1 10602479 (1)
    lipid 0 1 10932079 (1)



    Find genes that share compounds with PTPMT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTPMT1 gene (2 alternative transcripts): 
    NM_001143984.1  NM_175732.2  

    Unigene Cluster for PTPMT1:

    Protein tyrosine phosphatase, mitochondrial 1
    Hs.656205  [show with all ESTs]
    Unigene Representative Sequence: NM_175732
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426530 ENST00000534775 ENST00000326656 ENST00000326674 ENST00000527079(uc001nfs.4 uc001nfv.4 uc009ylt.3 uc001nfu.4)

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    Additional mRNA sequence: 

    AF277187.1 AK294640.1 AY333987.1 BC018974.1 BC020242.1 BC073798.1 BC107573.1 

    12 DOTS entries:

    DT.92444702  DT.100821907  DT.99980096  DT.100029638  DT.120735689  DT.120735620  DT.92444700  DT.92444706 
    DT.120735745  DT.85104508  DT.97786066  DT.100717211 

    Selected AceView cDNA sequences (see all 577):

    BQ427661 AI095776 BI439155 CB113394 BU728433 N44482 CK299448 BM702241 
    BU622774 BQ635942 AY333987 BP428570 BU736206 AL135819 BM549265 BM820491 
    CR614929 BF102519 CB850769 BC073798 W94084 BM470399 BG163439 T24485 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTPMT1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:                                                                                      -                                   -                     
    SP2:                                                                                      -                                   -                     
    SP3:                                                                                                                                                
    SP4:                                                                                      -                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PTPMT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTPMT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTPMT1 Expression
    About this image

    PTPMT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTPMT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656205
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTPMT1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpmt11 , 5 protein tyrosine phosphatase, mitochondrial 11, 5 87.05(n)1
    84.46(a)1
      2 (50.44 cM)5
    664611  NM_025576.21  NP_079852.11 
     909087165 
    chicken
    (Gallus gallus)
    Aves PTPMT11 protein tyrosine phosphatase, mitochondrial 1 69.47(n)
    65.79(a)
      423181  NM_001277882.1  NP_001264811.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTPMT16
    protein tyrosine phosphatase, mitochondrial 1
    56(a)
    1 ↔ 1
    1(44261702-44268046)
    zebrafish
    (Danio rerio)
    Actinopterygii ptpmt11 protein tyrosine phosphatase, mitochondrial 1 59.7(n)
    57.06(a)
      567019  NM_001080187.1  NP_001073656.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Plip1 PTEN-like phosphatase 56.98(n)
    45.93(a)
      42807  NM_142923.3  NP_651180.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F28C6.81 F28C6.8 45.54(n)
    37.16(a)
      174381  NM_001267232.1  NP_001254161.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G566101 AT5G56610 46.78(n)
    40.91(a)
      835762  NM_125044.3  NP_200472.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g05242001 Os05g0524200 49.43(n)
    41.95(a)
      4339367  NM_001062623.1  NP_001056088.1 


    ENSEMBL Gene Tree for PTPMT1 (if available)
    TreeFam Gene Tree for PTPMT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PTPMT1 (see all 151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001240261,2
    Cuntested147593121(+) GAGTTC/TCACAA 3 F syn1 ut311Minor allele frequency- T:0.00EU 1323
    rs1434741101,2
    --47585000(+) TGGGAA/GACCAA 2 -- us2k10--------
    rs1857276451,2
    --47585087(+) ACACAA/CAAAAT 2 -- us2k10--------
    rs1889728581,2
    C--47585107(+) ATGGTA/GGCGGG 2 -- us2k10--------
    rs1817273561,2
    --47585109(+) GGTGGC/TGGGCA 2 -- us2k10--------
    rs1862262321,2
    --47585197(+) GATGGC/TGCCAC 2 -- us2k10--------
    rs110392981,2
    F,H--47585198(+) ATGGCA/GCCACT 2 -- us2k16Minor allele frequency- G:0.21NS EA CSA WA 538
    rs1422234951,2
    C--47585254(+) AATAT-/AAAAAA 2 -- us2k10--------
    rs71263781,2
    C,F,A--47585348(+) gggacG/Tgatct 2 -- us2k17Minor allele frequency- T:0.32NA WA EA 366
    rs1920759931,2
    --47585513(+) GATCAC/TGCCAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTPMT1 (47586982 - 47595013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PTPMT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509405CNV Insertion20534489
    nsv897325CNV Loss21882294
    nsv314CNV Loss18451855
    nsv832142CNV Loss17160897
    nsv825872CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTPMT1
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPMT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609538    OMIM disorders: --

    2 diseases for PTPMT1:    
    About MalaCards
    cogan's syndrome    stomach cancer

    1 disease from the University of Copenhagen DISEASES database for PTPMT1:
    Centronuclear myopathy

    Find genes that share disorders with PTPMT1           About GenesLikeMe

    1 Novoseek inferred disease relationship for PTPMT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 2 9544992 (1), 10602479 (1)


    Export disorders for PTPMT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTPMT1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with PTPMT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. (PubMed id 23326511)1 Niemi N.M....MacKeigan J.P. (PLoS ONE 2013)
    4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114971 HGNC: 26965 AceView: NDUFS3andPLIP Ensembl:ENSG00000110536 euGenes: HUgn114971
    ECgene: PTPMT1 H-InvDB: PTPMT1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTPMT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PTPMT1 gene:
    Search GeneIP for patents involving PTPMT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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