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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPLA Gene

protein-coding   GIFtS: 55
GCID: GC10M017631

Protein Tyrosine Phosphatase-Like (Proline Instead Of Catalytic...

(Previous names: protein tyrosine phosphatase-like (proline instead of catalytic...)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase-Like (Proline Instead Of Catalytic
Arginine), Member A1 2
     HACD12 3
Cementum Attachment Protein1 2 3     CAP2
Protein-Tyrosine Phosphatase-Like Member A2 3     Very-Long-Chain (3R)-3-Hydroxyacyl-[Acyl-Carrier Protein] Dehydratase 12
3-Hydroxyacyl-CoA Dehydratase 12 3     EC 4.2.1.1343

External Ids:    HGNC: 96391   Entrez Gene: 92002   Ensembl: ENSG000001659967   OMIM: 6104675   UniProtKB: B0YJ813   

Export aliases for PTPLA gene to outside databases

Previous GC identifers: GC10M017614 GC10M017782 GC10M017636 GC10M017672


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTPLA Gene:
The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases
(PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline
residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling
molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and
fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression
was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role
in regulating cardiac development and differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTPLA Gene: 
PTPLA (protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A) is a protein-coding gene. Diseases associated with PTPLA include arrhythmogenic right ventricular dysplasia, and centronuclear myopathy, and among its related super-pathways are Fatty acid elongation. GO annotations related to this gene include lyase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPLAD2.

UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81
Function: Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPLA gene promoter:
         POU2F2 (Oct-2.1)   POU3F1   FOXO3   POU2F2   FOXO3b   POU2F2C   POU2F1   POU2F1a   FOXO3a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTPLA promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPLA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14-p13   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p14-p13

PTPLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPLA gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M017631:  view genomic region     (about GC identifiers)

Start:
17,631,958 bp from pter      End:
17,659,376 bp from pter
Size:
27,419 bases      Orientation:
minus strand

1 alternative location:
Chr10-,NW_003315932 18,750-46,165     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81 (See protein sequence)
Recommended Name: Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1  
Size: 288 amino acids; 32388 Da
Subunit: Interacts with the condensation enzymes of the ELOVL family
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Developmental stage: Expressed in fetal heart
Caution: Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity
Sequence caution: Sequence=AAG10713.1; Type=Erroneous initiation; Sequence=ACA06059.1; Type=Erroneous initiation;
Secondary accessions: B0YJ80 Q6JIC5 Q96FW7 Q9HB93 Q9UHX2
Alternative splicing: 2 isoforms:  B0YJ81-1   B0YJ81-2   

Explore the universe of human proteins at neXtProt for PTPLA: NX_B0YJ81

Explore proteomics data for PTPLA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_B0YJ81

  • PTPLA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTPLA Protein Expression
    REFSEQ proteins: NP_055056.3  
    ENSEMBL proteins: 
     ENSP00000355308   ENSP00000462868   ENSP00000462336   ENSP00000322923  

    Human Recombinant Protein Products for PTPLA: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    PTPLA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007482 Tyr_Pase-like_PTPLA

    Graphical View of Domain Structure for InterPro Entry B0YJ81

    ProtoNet protein and cluster: B0YJ81

    UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81
    Similarity: Belongs to the very long-chain fatty acids dehydratase HACD family


    PTPLA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HACD1_HUMAN, B0YJ81
    Function: Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis
    Catalytic activity: A very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] = a very-long-chain
    trans-2,3-dehydroacyl-[acyl-carrier protein] + H(2)O

         Genatlas biochemistry entry for PTPLA:
    protein tyrosine phosphatase-like gene,member A,expressed in the developing and in adult heart,skeletal
    muscle,liver,testis,kidney

         Enzyme Number (IUBMB): EC 4.2.1.1341

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity TAS10644438
    GO:0016829lyase activity IEA--
         
    PTPLA for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    hsa-miR-890 hsa-miR-875-3p hsa-miR-3658 hsa-miR-578 hsa-miR-3148 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidPTPLA 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTPLA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    Fatty acid elongation0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for PTPLA):
        Fatty acid elongation
    Biosynthesis of unsaturated fatty acids


    PTPLA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTPLA

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS10644438
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0007165signal transduction NAS10644438
    GO:0007275multicellular organismal development IEA--
    GO:0035335peptidyl-tyrosine dephosphorylation TAS10644438

    PTPLA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPLA (HACD1)

    Search CenterWatch for drugs/clinical trials and news about PTPLA / HACD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTPLA gene: 
    NM_014241.3  

    Unigene Cluster for PTPLA:

    Protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
    Hs.114062  [show with all ESTs]
    Unigene Representative Sequence: AY455942
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361271(uc001ipg.3 uc001iph.1) ENST00000498812 ENST00000471481
    ENST00000466335 ENST00000326961(uc001ipi.3)

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPLA:
    hsa-miR-890 hsa-miR-875-3p hsa-miR-3658 hsa-miR-578 hsa-miR-3148 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidPTPLA 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF114494.1 AY455942.1 BC010353.1 BC027709.2 

    7 DOTS entries:

    DT.307676  DT.100754130  DT.91956856  DT.92066360  DT.87046827  DT.91680246  DT.99951094 

    24/40 AceView cDNA sequences (see all 40):

    CR608689 AY455942 AI421808 AA906877 BC010353 BG150321 BU753528 AI554017 
    NM_014241 BU848953 CD299090 BC027709 BG770900 AL526596 AI421699 CD299469 
    AA701448 BE501654 BG339916 BF686638 AI085893 BF672476 BI545706 AW173524 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPLA expression in normal human tissues (normalized intensities)      PTPLA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGTGAT
    PTPLA Expression
    About this image


    PTPLA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells ( Generation of mesendoderm and definitive endoderm...

    See PTPLA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPLA

    SOURCE GeneReport for Unigene cluster: Hs.114062

    UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81
    Tissue specificity: Highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular
    tissues including those from stomach, jejunum, and bladder

        SABiosciences Expression via Pathway-Focused PCR Array including PTPLA: 
              Protein Phosphatases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTPLA gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptpla1 , 5 protein tyrosine phosphatase-like (proline instead more1, 5 88.71(n)1
    92.74(a)1
      2 (10.30 cM)5
    309631  NM_013935.31  NP_038963.31 
     139755635 
    chicken
    (Gallus gallus)
    Aves PTPLA1 protein tyrosine phosphatase-like (proline instead more 84.65(n)
    85.64(a)
      420518  XM_418620.3  XP_418620.2 
    lizard
    (Anolis carolinensis)
    Reptilia PTPLA6
    protein tyrosine phosphatase-like (proline instead...
    87(a)
    1 ↔ 1
    6(18154636-18177316)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5533261 uncharacterized LOC553326 71.9(n)
    75.62(a)
      553326  XM_694691.4  XP_699783.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67463   -- 33(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T15B7.23   -- 41(a)   V(6841886-6843068)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHS1(YJL097W)4
    PHS11
    Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, more4
    Phs1p1
    46.7(n)1
    36.46(a)1
      10(245591-246244)4
    8533481, 4  NP_012438.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os01g01505001 hypothetical protein 46.63(n)
    36.95(a)
      4324520  NM_001048569.2  NP_001042034.2 


    ENSEMBL Gene Tree for PTPLA (if available)
    TreeFam Gene Tree for PTPLA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPLA gene
    PTPLAD22  PTPLAD12  PTPLB2  
    18/28 SIMAP similar genes for PTPLA using alignment to 5 protein entries:     HACD1_HUMAN (see all proteins) (see all similar genes):
    RPL27A    NF2    PTPLB    DCTN5    ZNF564    ZNF737
    LAMB4    AURA2    FAM175A    LYRM4    HKR1    LINC00596
    OCEL1    EPS15    FCHO2    UTY    TSEN2    LEPROTL1

    PTPLA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/710 SNPs in PTPLA are shown (see all 710)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917984341,2
    --17574342(+) AAAGAG/TCTAAA 1 -- us2k10--------
    rs1150466491,2
    F--17574352(+) ATAAAT/CAGCTG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs127800321,2
    C,F,A,H--17574360(+) ctgttG/Ccctgt 1 -- us2k112Minor allele frequency- C:0.19NS EA WA NA 1196
    rs1394756421,2
    --17574390(+) ATACTA/GTTAAA 1 -- us2k10--------
    rs1158262881,2
    F--17631813(+) TGTGTT/CTTTAT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1459887241,2
    C--17631839(+) ACATC-/AAAAGTC 1 -- ds50010--------
    rs1144181381,2
    F--17631852(+) TACTTT/CAGCAA 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1873582821,2
    --17631855(+) TTTAGC/TAAATT 1 -- ds50010--------
    rs793653691,2
    F--17631868(+) ATCCAC/TGCTTC 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs801718461,2
    C--17631903(+) CCTTA-/TTTCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PTPLA (17631958 - 17659376 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTPLA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669454CNV Deletion23128226
    esv1789699CNV Insertion17803354
    nsv894912CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610467    OMIM disorders: --

    4 diseases for PTPLA:    About MalaCards
    arrhythmogenic right ventricular dysplasia    centronuclear myopathy    myopathy    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for PTPLA:
    Centronuclear myopathy     Arrhythmogenic right ventricular dysplasia

    PTPLA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PTPLA
    Human Genome Epidemiology (HuGE) Navigator: PTPLA (4 documents)

    Export disorders for PTPLA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPLA gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with PTPLA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene. (PubMed id 10644438)1, 2, 3, 9 Uwanogho D.A.... Sharpe P.T. (1999)
    2. Human protein tyrosine phosphatase-like gene: expression profile, genomic structure, and mutation analysis in families with ARVD. (PubMed id 11054553)1, 2, 9 Li D.... Roberts R. (2000)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Isolation of protein-tyrosine phosphatase-like member- a variant from cementum. (PubMed id 22067203)1 Valdes De Hoyos A....Narayanan A.S. (2012)
    7. Characterization of HACD1 K64Q mutant found in arrhyt hmogenic right ventricular dysplasia patients. (PubMed id 20724468)1 Konishi H....Kihara A. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. Genomic convergence to identify candidate genes for A lzheimer disease on chromosome 10. (PubMed id 19241460)1 Liang X....Haines J.L. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9200 HGNC: 9639 AceView: PTPLA Ensembl:ENSG00000165996 euGenes: HUgn9200
    ECgene: PTPLA Kegg: 9200 H-InvDB: PTPLA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPLA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTPLA gene:
    Search GeneIP for patents involving PTPLA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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