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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTPLA Gene

protein-coding   GIFtS: 51
GCID: GC10M017631

protein tyrosine phosphatase-like (proline instead of catalytic...

(Previous names: protein tyrosine phosphatase-like (proline instead of catalytic...)
 Explore 5 diseases affiliated with
PTPLA via
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Biological research products
for PTPLA    

Aliases
for PTPLA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Phosphatase-Like (Proline Instead Of Catalytic Arginine),
Member A1 2
     3-Hydroxyacyl-CoA Dehydratase 12 3
CAP1 2     HACD12 3
Cementum Attachment Protein2 3     Very-Long-Chain (3R)-3-Hydroxyacyl-[Acyl-Carrier Protein] Dehydratase 12
Protein-Tyrosine Phosphatase-Like Member A2 3     EC 4.2.1.1343

External Ids:    HGNC: 96391   Entrez Gene: 92002   Ensembl: ENSG000001659967   OMIM: 6104675   UniProtKB: B0YJ813   

Export aliases for PTPLA gene to outside databases

Previous GC identifers: GC10M017614 GC10M017782 GC10M017636 GC10M017672


Summaries
for PTPLA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTPLA:
The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs)
family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it
may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a
variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower
expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues.
The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and
differentiation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81
Function: Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis




Genomic Views
for PTPLA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTPLA gene promoter:
         POU2F2 (Oct-2.1)   POU3F1   FOXO3   POU2F2   FOXO3b   POU2F2C   POU2F1   POU2F1a   FOXO3a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTPLA promoter sequence
   Search SABiosciences Chromatin IP Primers for PTPLA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTPLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14-p13   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p14-p13

PTPLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTPLA gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M017631:  view genomic region     (about GC identifiers)

Start:
 17,631,958 bp from pter      End:
 17,659,376 bp from pter
Size:
 27,419 bases      Orientation:
 minus strand

1 alternative location:
Chr10-,PATCHES 17,755,423-17,782,838     

Proteins
for PTPLA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81 (See protein sequence)
Recommended Name: Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1  
Size: 288 amino acids; 32388 Da
Subunit: Interacts with the condensation enzymes of the ELOVL family
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Developmental stage: Expressed in fetal heart
Caution: Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity
Sequence caution: Sequence=AAG10713.1; Type=Erroneous initiation; Sequence=ACA06059.1; Type=Erroneous initiation;
Secondary accessions: B0YJ80 Q6JIC5 Q96FW7 Q9HB93 Q9UHX2
Alternative splicing: 2 isoforms:  B0YJ81-1   B0YJ81-2   

Explore the universe of human proteins at neXtProt for PTPLA: NX_B0YJ81

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_B0YJ81

    • PTPLA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055056.3  
    ENSEMBL proteins: 
     ENSP00000355308   ENSP00000462868   ENSP00000462336   ENSP00000322923  

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    Uscn Proteins for PTPLA

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    PTPLA for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PTPLA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTPLA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007482 Tyr_Pase-like_PTPLA

    Graphical View of Domain Structure for InterPro Entry B0YJ81

    ProtoNet protein and cluster: B0YJ81

    UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81
    Similarity: Belongs to the very long-chain fatty acids dehydratase HACD family


    Function
    for PTPLA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81
    Function: Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis
    Catalytic activity: A very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] = a very-long-chain
    trans-2,3-dehydroacyl-[acyl-carrier protein] + H(2)O

         Genatlas biochemistry entry for PTPLA:
    protein tyrosine phosphatase-like gene,member A,expressed in the developing and in adult heart,skeletal
    muscle,liver,testis,kidney

    Enzyme Number (IUBMB): EC 4.2.1.1341

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPLA
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPLA:
    hsa-miR-890 hsa-miR-875-3p hsa-miR-3658 hsa-miR-578 hsa-miR-3148 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmid: PTPLA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPLA (see all 7)
    OriGene shRNA RFP: PTPLA
    OriGene siRNA: PTPLA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPLA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PTPLA

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PTPLA

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity TAS10644438
    GO:0016829lyase activity IEA--


    PTPLA for ontologies           About GeneDecksing



    Pathways & Interactions
    for PTPLA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Biosynthesis of unsaturated fatty acids
    		Biosynthesis of unsaturated fatty acids1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for PTPLA):
        Biosynthesis of unsaturated fatty acids


    PTPLA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTPLA

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS10644438
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0007165signal transduction NAS10644438
    GO:0007275multicellular organismal development IEA--
    GO:0035335peptidyl-tyrosine dephosphorylation TAS10644438


    PTPLA for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTPLA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTPLA
    Search CenterWatch for drugs/clinical trials and news about PTPLA / HACD1 

    Transcripts
    for PTPLA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTPLA gene: 
    NM_014241.3  

    Unigene Cluster for PTPLA:

    Protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
    Hs.114062  [show with all ESTs]
    Unigene Representative Sequence: AY455942
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361271(uc001ipg.3 uc001iph.1) ENST00000498812 ENST00000471481
    ENST00000466335 ENST00000326961(uc001ipi.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTPLA
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PTPLA:
    hsa-miR-890 hsa-miR-875-3p hsa-miR-3658 hsa-miR-578 hsa-miR-3148 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmid: PTPLA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTPLA (see all 7)
    OriGene shRNA RFP: PTPLA
    OriGene siRNA: PTPLA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTPLA
    Clone
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    GenScript: all cDNA clones in your preferred vector: PTPLA (NM_014241)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTPLA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTPLA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTPLA

    Additional cDNA sequence: 

    AF114494.1 AY455942.1 BC010353.1 BC027709.2 

    7 DOTS entries:

    DT.307676  DT.100754130  DT.91956856  DT.92066360  DT.87046827  DT.91680246  DT.99951094 

    24/40 AceView cDNA sequences (see all 40):

    AA906877 CR608689 AI421808 AY455942 BU848953 BC027709 CD299090 AI421699 
    CD299469 NM_014241 BC010353 BG770900 BG150321 BG339916 AL526596 BU753528 
    AI554017 AA701448 BE501654 BF672476 N24848 BI545706 CA950187 N67509 

    GeneLoc Exon Structure


    Expression
    for PTPLA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTPLA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAGGTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTPLA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTPLA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTPLA

    SOURCE GeneReport for Unigene cluster: Hs.114062

    UniProtKB/Swiss-Prot: HACD1_HUMAN, B0YJ81
    Tissue specificity: Highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues
    including those from stomach, jejunum, and bladder

        SABiosciences Expression via Pathway-Focused PCR Array including PTPLA: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PTPLA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTPLA gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ptpla1 , 5 protein tyrosine phosphatase-like (proline instead more1, 5 88.71(n)1
    92.74(a)1    		   2 (10.30 cM)5
    309631  NM_013935.31  NP_038963.31 
     139755635 
    chicken
    (Gallus gallus)    		 Aves PTPLA1 protein tyrosine phosphatase-like (proline instead more 84.65(n)
    85.64(a)    		   420518  XM_418620.3  XP_418620.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5533261 uncharacterized LOC553326 71.9(n)
    75.62(a)    		   553326  XM_694691.4  XP_699783.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG67463   -- 33(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea T15B7.23   -- 41(a)   V(6841886-6843068)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PHS1(YJL097W)4
    PHS11    		 Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, more4
    Phs1p1    		 46.7(n)1
    36.46(a)1    		   10(245591-246244)4
    8533481, 4  NP_012438.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PEP6
    		 3-hydroxyacyl-CoA dehydratase PASTICCINO 2
    		 35(a)
    		 possible ortholog
    		 5(3297804-3300151)
    rice
    (Oryza sativa)    		 Liliopsida Os01g01505001 hypothetical protein 46.63(n)
    36.95(a)    		   4324520  NM_001048569.2  NP_001042034.2 


    ENSEMBL Gene Tree for PTPLA (if available)
    TreeFam Gene Tree for PTPLA (if available) 

    Paralogs
    for PTPLA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTPLA gene
    PTPLAD22  PTPLAD12  PTPLB2  
    18/27 SIMAP similar genes for PTPLA using alignment to 5 protein entries:     HACD1_HUMAN (see all proteins) (see all similar genes):
    RPL27A    NF2    PTPLB    DCTN5    ZNF564    LAMB4
    AURA2    FAM175A    LYRM4    HKR1    LINC00596    EPS15
    FCHO2    UTY    TSEN2    LEPROTL1    SPATS2L    ZNF195

    PTPLA for paralogs           About GeneDecksing



    Genomic Variants
    for PTPLA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/607 NCBI SNPs in PTPLA are shown (see all 607)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1158262881,2
    		F,--17631813(+) TGTGTT/CTTTAT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1459887241,2
    		C,--17631839(+) ACATC-/AAAAGTC 1 -- ds50010--------
    rs1144181381,2
    		--17631852(+) TACTTT/CAGCAA 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1873582821,2
    		--17631855(+) TTTAGC/TAAATT 1 -- ds50010--------
    rs793653691,2
    		--17631868(+) ATCCAC/TGCTTC 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs801718461,2
    		C,--17631903(+) CCTTA-/TTTCCT 1 -- ds50010--------
    rs455299331,2
    		C,F--17631906(+) TTATTT/-CCTGA 1 -- ds50011Minor allele frequency- -:0.31NS 36
    rs413102191,2
    		C,F,--17631928(+) TGTGGG/TTTCAA 1 -- ds50013Minor allele frequency- T:0.05NS NA EA 276
    rs762411841,2
    		C,F,--17631974(+) TTGCAT/CTNNNN 1 -- ut311Minor allele frequency- C:0.07EA 120
    rs413068061,2
    		C,F,--17631990(+) TTATAA/GATATC 1 -- ut314Minor allele frequency- G:0.26NA NS 154

    HapMap Linkage Disequilibrium report for PTPLA (17631958 - 17659376 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PTPLA: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTPLA
    DNA2.0 Custom Variant and Variant Library Synthesis for PTPLA

    Disorders / Diseases
    for PTPLA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTPLA for disorders           About GeneDecksing

    OMIM gene information: 610467    OMIM disorders: --

    5 diseases for PTPLA:    About MalaCards
    arrhythmogenic right ventricular dysplasia    centronuclear myopathy    myopathy    alzheimer's disease
    malaria

    2 diseases from the University of Copenhagen DISEASES database for PTPLA:
    Centronuclear myopathy     Arrhythmogenic right ventricular dysplasia
    Human Genome Epidemiology (HuGE) Navigator: PTPLA (4 documents)

    Export disorders for PTPLA gene to outside databases

    Publications
    for PTPLA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTPLA gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with PTPLA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene. (PubMed id 10644438)1, 2, 3, 9 Uwanogho D.A.... Sharpe P.T. (1999)
    2. Human protein tyrosine phosphatase-like gene: expression profile, genomic structure, and mutation analysis in families with ARVD. (PubMed id 11054553)1, 2, 9 Li D.... Roberts R. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Isolation of protein-tyrosine phosphatase-like member- a variant from cementum. (PubMed id 22067203)1 Valdes De Hoyos A....Narayanan A.S. (2012)
    5. Characterization of HACD1 K64Q mutant found in arrhyt hmogenic right ventricular dysplasia patients. (PubMed id 20724468)1 Konishi H....Kihara A. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. Genomic convergence to identify candidate genes for A lzheimer disease on chromosome 10. (PubMed id 19241460)1 Liang X....Haines J.L. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. (PubMed id 18554506)2 Ikeda M.... Kihara A. (2008)

    External Searches for PTPLA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PTPLA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9200 HGNC: 9639 AceView: PTPLA Ensembl:ENSG00000165996 euGenes: HUgn9200
    ECgene: PTPLA Kegg: 9200 H-InvDB: PTPLA

    Other Databases showing PTPLA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTPLA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTPLA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PTPLA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTPLA gene:
    Search GeneIP for patents involving PTPLA

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