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Aliases for PTP4A3 Gene

Aliases for PTP4A3 Gene

  • Protein Tyrosine Phosphatase Type IVA, Member 3 2 3
  • PRL3 3 4 6
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 3 3 4
  • Protein-Tyrosine Phosphatase 4a3 3 4
  • EC 3.1.3.48 4 63
  • PRL-R 3 4
  • PRL-3 3 4
  • Potentially Prenylated Protein Tyrosine Phosphatase 3
  • Protein Tyrosine Phosphatase Type IVA 3 3

External Ids for PTP4A3 Gene

Previous GeneCards Identifiers for PTP4A3 Gene

  • GC00U990504
  • GC08U900031
  • GC08P142111
  • GC08P142403
  • GC08P142501
  • GC08P142432
  • GC08P137749

Summaries for PTP4A3 Gene

Entrez Gene Summary for PTP4A3 Gene

  • This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTP4A3 Gene

PTP4A3 (Protein Tyrosine Phosphatase Type IVA, Member 3) is a Protein Coding gene. Among its related pathways are PAK Pathway and Signaling events mediated by PRL. GO annotations related to this gene include prenylated protein tyrosine phosphatase activity. An important paralog of this gene is PTP4A1.

UniProtKB/Swiss-Prot for PTP4A3 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Gene Wiki entry for PTP4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTP4A3 Gene

Genomics for PTP4A3 Gene

Regulatory Elements for PTP4A3 Gene

Transcription factor binding sites by QIAGEN in the PTP4A3 gene promoter:

Genomic Location for PTP4A3 Gene

Start:
141,391,993 bp from pter
End:
141,432,454 bp from pter
Size:
40,462 bases
Orientation:
Plus strand

Genomic View for PTP4A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTP4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A3 Gene

Proteins for PTP4A3 Gene

  • Protein details for PTP4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75365-TP4A3_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 3
    Protein Accession:
    O75365
    Secondary Accessions:
    • Q8IVN5
    • Q99849
    • Q9BTW5

    Protein attributes for PTP4A3 Gene

    Size:
    173 amino acids
    Molecular mass:
    19535 Da
    Quaternary structure:
    • Interacts with tubulin.

    Three dimensional structures from OCA and Proteopedia for PTP4A3 Gene

    Alternative splice isoforms for PTP4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTP4A3 Gene

Proteomics data for PTP4A3 Gene at MOPED

Selected DME Specific Peptides for PTP4A3 Gene

Post-translational modifications for PTP4A3 Gene

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTP4A3 Gene

Antibody Products

  • R&D Systems Antibodies for PTP4A3 (PRL-3/PTP4A3)
  • Cell Signaling Technology (CST) Antibodies for PTP4A3 (PTP4A3)

Domains for PTP4A3 Gene

Gene Families for PTP4A3 Gene

HGNC:
  • DUSPP :Protein tyrosine phosphatases / Class I Cys-based PTPs : PRLs

Protein Domains for PTP4A3 Gene

Suggested Antigen Peptide Sequences for PTP4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75365

UniProtKB/Swiss-Prot:

TP4A3_HUMAN :
  • O75365
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A3: view

Function for PTP4A3 Gene

Molecular function for PTP4A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.
UniProtKB/Swiss-Prot Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Enzyme Numbers (IUBMB) for PTP4A3 Gene

Gene Ontology (GO) - Molecular Function for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity --
GO:0004727 prenylated protein tyrosine phosphatase activity TAS 9514946
GO:0008138 protein tyrosine/serine/threonine phosphatase activity --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with PTP4A3: view
genes like me logo Genes that share phenotypes with PTP4A3: view

Animal Models for PTP4A3 Gene

MGI Knock Outs for PTP4A3:

Animal Model Products

CRISPR Products

miRNA for PTP4A3 Gene

miRTarBase miRNAs that target PTP4A3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTP4A3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PTP4A3 Gene

Localization for PTP4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A3 Gene

Cell membrane. Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTP4A3 Gene COMPARTMENTS Subcellular localization image for PTP4A3 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PTP4A3: view

Pathways for PTP4A3 Gene

genes like me logo Genes that share pathways with PTP4A3: view

Pathways by source for PTP4A3 Gene

1 Qiagen pathway for PTP4A3 Gene
1 BioSystems pathway for PTP4A3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 9514946
GO:0043542 endothelial cell migration IMP 24403062
genes like me logo Genes that share ontologies with PTP4A3: view

Compounds for PTP4A3 Gene

(4) HMDB Compounds for PTP4A3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Sodium
  • Sodium
7440-23-5
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with PTP4A3: view

Transcripts for PTP4A3 Gene

Unigene Clusters for PTP4A3 Gene

Protein tyrosine phosphatase type IVA, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTP4A3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PTP4A3 Gene

GeneLoc Exon Structure for
PTP4A3
ECgene alternative splicing isoforms for
PTP4A3

Expression for PTP4A3 Gene

mRNA expression in normal human tissues for PTP4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTP4A3 Gene

This gene is overexpressed in Muscle - Skeletal (7.8), Heart - Left Ventricle (7.7), and Heart - Atrial Appendage (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTP4A3 Gene

SOURCE GeneReport for Unigene cluster for PTP4A3 Gene Hs.744870

mRNA Expression by UniProt/SwissProt for PTP4A3 Gene

O75365-TP4A3_HUMAN
Tissue specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
genes like me logo Genes that share expressions with PTP4A3: view

In Situ Assay Products

Orthologs for PTP4A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTP4A3 35
  • 99.04 (n)
  • 99.42 (a)
PTP4A3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTP4A3 35
  • 89.98 (n)
  • 94.22 (a)
PTP4A3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTP4A3 35
  • 89.4 (n)
  • 95.38 (a)
PTP4A3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptp4a3 35
  • 88.63 (n)
  • 96.53 (a)
Ptp4a3 16
Ptp4a3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTP4A3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A3 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptp4a3 35
  • 88.44 (n)
  • 96.53 (a)
chicken
(Gallus gallus)
Aves PTP4A3 35
  • 82.85 (n)
  • 91.33 (a)
PTP4A3 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTP4A3 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptp4a3 35
  • 77.65 (n)
  • 89.02 (a)
zebrafish
(Danio rerio)
Actinopterygii ptp4a3 35
  • 77.65 (n)
  • 87.28 (a)
PTP4A3 36
  • 75 (a)
OneToOne
wufc54b05 35
fruit fly
(Drosophila melanogaster)
Insecta PRL-1 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T19D2.2 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10622 36
  • 66 (a)
OneToMany
Species with no ortholog for PTP4A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTP4A3 Gene

ENSEMBL:
Gene Tree for PTP4A3 (if available)
TreeFam:
Gene Tree for PTP4A3 (if available)

Paralogs for PTP4A3 Gene

Paralogs for PTP4A3 Gene

Selected SIMAP similar genes for PTP4A3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTP4A3: view

Variants for PTP4A3 Gene

Sequence variations from dbSNP and Humsavar for PTP4A3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1129594 -- 141,431,250(+) CCTTT(C/G/T)TCCTG utr-variant-3-prime
rs1129628 -- 141,431,417(+) CCCCT(C/T)TTTTG utr-variant-3-prime
rs1132917 -- 141,432,291(+) CCCTT(C/T)TCAGG utr-variant-3-prime
rs3087694 -- 141,432,307(-) CTTGG(A/G)GGCAG utr-variant-3-prime
rs3935961 -- 141,401,965(-) CGGGG(A/C)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTP4A3 Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV Deletion 23290073
dgv7895n71 CNV Loss 21882294
nsv465956 CNV Gain 19166990
dgv7896n71 CNV Loss 21882294
nsv470240 CNV Loss 18288195
dgv7897n71 CNV Loss 21882294
nsv509285 CNV Insertion 20534489
nsv465958 CNV Loss 19166990
nsv891565 CNV Loss 21882294
nsv465959 CNV Loss 19166990
dgv7898n71 CNV Loss 21882294
nsv891569 CNV Loss 21882294
esv1011203 CNV Insertion 20482838
nsv6431 CNV Insertion 18451855
nsv824751 CNV Gain 20364138
dgv7899n71 CNV Loss 21882294
dgv902n27 CNV Loss 19166990
dgv7900n71 CNV Loss 21882294
esv2737782 CNV Deletion 23290073
esv22902 CNV Loss 19812545
esv1265503 CNV Insertion 17803354
esv1420349 CNV Insertion 17803354
esv1229387 CNV Insertion 17803354
nsv891577 CNV Gain 21882294

Relevant External Links for PTP4A3 Gene

HapMap Linkage Disequilibrium report
PTP4A3

PCR Panel Products

  • Copy Number PCR Panels: for PTP4A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A3 Gene

Disorders for PTP4A3 Gene

(2) Novoseek inferred disease relationships for PTP4A3 Gene

Disease -log(P) Hits PubMed IDs
metastasis 14 4
tumors 4.65 1
genes like me logo Genes that share disorders with PTP4A3: view

No data available for UniProtKB/Swiss-Prot for PTP4A3 Gene

Publications for PTP4A3 Gene

  1. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. (PMID: 11355880) Matter W.F. … Vlahos C.J. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. (PMID: 9633825) Dayton M.A. … Knobloch T.J. (Recept. Signal Transduct. 1997) 3 4
  3. Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. (PMID: 15161639) Wu X. … Xu Q. (Am. J. Pathol. 2004) 3 23
  4. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. (PMID: 15788667) Li J. … Zeng Q. (Clin. Cancer Res. 2005) 3 23
  5. Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer. (PMID: 17717498) Yamashita S. … Kawahara K. (Ann Thorac Cardiovasc Surg 2007) 3 23

Products for PTP4A3 Gene

Sources for PTP4A3 Gene

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