Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTP4A3 Gene

protein-coding   GIFtS: 63
GCID: GC08P142432

Protein Tyrosine Phosphatase Type IVA, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Tyrosine Phosphatase Type IVA, Member 31 2     PRL-R2 3
PRL32 3 5     EC 3.1.3.483 8
Protein-Tyrosine Phosphatase 4a32 3     Potentially Prenylated Protein Tyrosine Phosphatase2
Protein-Tyrosine Phosphatase Of Regenerating Liver 32 3     Protein Tyrosine Phosphatase Type IVA 32
PRL-32 3     

External Ids:    HGNC: 96361   Entrez Gene: 111562   Ensembl: ENSG000001844897   OMIM: 6064495   UniProtKB: O753653   

Export aliases for PTP4A3 gene to outside databases

Previous GC identifers: GC00U990504 GC08U900031 GC08P142111 GC08P142403 GC08P142501 GC08P137749


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTP4A3 Gene:
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell
signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of
protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association
with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene
has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2013)

GeneCards Summary for PTP4A3 Gene: 
PTP4A3 (protein tyrosine phosphatase type IVA, member 3) is a protein-coding gene. Diseases associated with PTP4A3 include esophageal squamous cell carcinoma, and colon adenocarcinoma, and among its related super-pathways are PAK Pathway. GO annotations related to this gene include prenylated protein tyrosine phosphatase activity. An important paralog of this gene is PTP4A1.

UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances
cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the
progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II

Gene Wiki entry for PTP4A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTP4A3 gene promoter:
         STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTP4A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTP4A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTP4A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

PTP4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTP4A3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P142432:  view genomic region     (about GC identifiers)

Start:
142,402,093 bp from pter      End:
142,441,620 bp from pter
Size:
39,528 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365 (See protein sequence)
Recommended Name: Protein tyrosine phosphatase type IVA 3 precursor  
Size: 173 amino acids; 19535 Da
Subunit: Interacts with tubulin
Subcellular location: Cell membrane. Early endosome
2 PDB 3D structures from and Proteopedia for PTP4A3:
1R6H (3D)        1V3A (3D)    
Secondary accessions: Q8IVN5 Q99849 Q9BTW5
Alternative splicing: 3 isoforms:  O75365-1   O75365-2   O75365-3   (Unstructured and inactive)

Explore the universe of human proteins at neXtProt for PTP4A3: NX_O75365

Explore proteomics data for PTP4A3 at MOPED 

Post-translational modifications:

  • UniProtKB: Farnesylated. Farnesylation is required for membrane targeting (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75365

  • 4/6 DME Specific Peptides for PTP4A3 (O75365) (see all 6)
     GMKYEDA  YLEKYRPK  MRFLITHNP  QFIRQKRRGA 

    PTP4A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTP4A3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_009010.2  NP_116000.1  

    ENSEMBL proteins: 
     ENSP00000428976   ENSP00000428758   ENSP00000428725   ENSP00000430332   ENSP00000332274  
     ENSP00000331730  

    Human Recombinant Protein Products for PTP4A3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PTP4A3
    OriGene Purified Proteins for PTP4A3
    OriGene Protein Over-expression Lysate for PTP4A3
    OriGene MassSpec for PTP4A3 
    OriGene Custom Protein Services for PTP4A3
    GenScript Custom Purified and Recombinant Proteins Services for PTP4A3
    Novus Biologicals PTP4A3 Proteins
    Novus Biologicals PTP4A3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PTP4A3
    Cloud-Clone Corp. Proteins for PTP4A3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane IEA--

    PTP4A3 for ontologies           About GeneDecksing



    PTP4A3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PTP4A3 (PRL-3/PTP4A3)
    OriGene Antibodies for PTP4A3
    OriGene Custom Antibody Services for PTP4A3
    GenScript Custom Superior Antibodies Services for PTP4A3
    Novus Biologicals PTP4A3 Antibodies
    Abcam antibodies for PTP4A3
    Cloud-Clone Corp. Antibodies for PTP4A3 
    ThermoFisher Antibodies for PTP4A3
    LSBio Antibodies in human, mouse, rat for PTP4A3 

    Assay Products for PTP4A3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTP4A3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTP4A3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTP4A3 
    Cloud-Clone Corp. CLIAs for PTP4A3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPP: Protein tyrosine phosphatases / Class I Cys-based PTPs : PRLs

    2 InterPro protein domains:
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry O75365

    ProtoNet protein and cluster: O75365

    UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    PTP4A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TP4A3_HUMAN, O75365
    Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances
    cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the
    progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004727prenylated protein tyrosine phosphatase activity TAS9514946
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
         
    PTP4A3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTP4A3:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptp4a3):
     growth/size  homeostasis/metabolism  mortality/aging  no phenotypic analysis  tumorigenesis 

    PTP4A3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptp4a3tm1.1Geh for PTP4A3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTP4A3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTP4A3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTP4A3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTP4A3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTP4A3:
    hsa-mir-192 (MIRT004166)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTP4A3
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PTP4A3:
    hsa-miR-140-5p hsa-miR-18a hsa-miR-137 hsa-miR-18b
    SwitchGear 3'UTR luciferase reporter plasmidPTP4A3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTP4A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTP4A3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTP4A3
    Sirion Biotech Customized adenovirus for overexpression of PTP4A3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTP4A3 (see all 13)
    OriGene ORF clones in mouse, rat for PTP4A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PTP4A3 (NM_007079)
    Sino Biological Human cDNA Clone for PTP4A3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTP4A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTP4A3
    Sirion Biotech Customized lentivirus for stable overexpression of PTP4A3 
                         Customized lentivirus expression plasmids for stable overexpression of PTP4A3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTP4A3
    Search LifeMap BioReagents cell lines for PTP4A3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTP4A3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTP4A3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Signaling events mediated by PRL
    Signaling events mediated by PRL

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTP4A3
        Epithelial Adherens Junctions

    1 BioSystems Pathway for PTP4A3
        Signaling events mediated by PRL



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTP4A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/116 Interacting proteins for PTP4A3 (O753653 ENSP000003322744) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNTAP493543, ENSP000003034234I2D: score=3 STRING: ENSP00000303423
    FNTBP493563, ENSP000002461664I2D: score=3 STRING: ENSP00000246166
    MSH2P432463, ENSP000002331464I2D: score=2 STRING: ENSP00000233146
    NCAPGQ9BPX33, ENSP000002514964I2D: score=2 STRING: ENSP00000251496
    RAB3GAP2Q9H2M93, ENSP000003518324I2D: score=2 STRING: ENSP00000351832
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0016311dephosphorylation ----

    PTP4A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PTP4A3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTP4A3 (TP4A3)

    4 HMDB Compounds for PTP4A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    SodiumSodium (see all 2)7440-23-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PTP4A3 / TP4A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTP4A3 gene (2 alternative transcripts): 
    NM_007079.3  NM_032611.2  

    Unigene Cluster for PTP4A3:

    Protein tyrosine phosphatase type IVA, member 3
    Hs.744870  [show with all ESTs]
    Unigene Representative Sequence: AK128380
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521578(uc010mes.3) ENST00000520105 ENST00000523147 ENST00000524028
    ENST00000329397(uc003ywg.1 uc010met.1) ENST00000349124(uc003ywh.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTP4A3
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PTP4A3:
    hsa-miR-140-5p hsa-miR-18a hsa-miR-137 hsa-miR-18b
    SwitchGear 3'UTR luciferase reporter plasmidPTP4A3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTP4A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTP4A3
    Clone
    Products:
         
    OriGene clones in human, mouse for PTP4A3 (see all 13)
    OriGene ORF clones in mouse, rat for PTP4A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PTP4A3 (NM_007079)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTP4A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTP4A3
    Sirion Biotech Customized lentivirus for stable overexpression of PTP4A3 
                         Customized lentivirus expression plasmids for stable overexpression of PTP4A3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PTP4A3
    OriGene qSTAR qPCR primer pairs in human, mouse for PTP4A3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTP4A3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTP4A3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTP4A3

    Additional mRNA sequence: 

    AF041434.1 AJ276554.1 AK128380.1 AY819648.1 BC003105.1 BT007303.1 U87168.1 

    8 DOTS entries:

    DT.86855102  DT.100027011  DT.407646  DT.100802459  DT.40133000  DT.100783221  DT.97827688  DT.121489739 

    24/192 AceView cDNA sequences (see all 192):

    NM_032611 BQ639361 AL542316 BQ637038 AA454501 AJ572627 BX439784 T19182 
    CK819091 BM791220 BM701686 BM790933 BC003105 AL550979 BM708902 BQ637188 
    AJ572032 AL528298 U87168 NM_007079 AW189182 BT007303 BQ881257 BQ636705 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A3    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                       -                           
    SP2:                                -                           
    SP3:                                -           -               
    SP4:                                                            


    ECgene alternative splicing isoforms for PTP4A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTP4A3 expression in normal human tissues (normalized intensities)      PTP4A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGTCAGGA
    PTP4A3 Expression
    About this image


    PTP4A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             vastus lateralis   
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Liver (Hepatobiliary System)

    See PTP4A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTP4A3

    SOURCE GeneReport for Unigene cluster: Hs.744870

    UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
    Tissue specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently
    overexpressed in colon cancer metastasis

        SABiosciences Expression via Pathway-Focused PCR Array including PTP4A3: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PTP4A3
    OriGene qSTAR qPCR primer pairs in human, mouse for PTP4A3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTP4A3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTP4A3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTP4A3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTP4A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTP4A3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptp4a31 , 5 protein tyrosine phosphatase 4a31, 5 88.44(n)1
    96.53(a)1
      15 (34.05 cM)5
    192451  NM_001166388.11  NP_001159860.11 
     737231455 
    chicken
    (Gallus gallus)
    Aves PTP4A31 protein tyrosine phosphatase type IVA, member 3 82.85(n)
    91.33(a)
      768713  XM_001231578.2  XP_001231579.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTP4A36
    Uncharacterized protein
    90(a)
    1 ↔ 1
    4(14931279-15001838)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc54b052 wufc54b05 79.03(n)   325062  CB358392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PRL-16
    PRL-1
    54(a)
    1 → many
    2L(16245835-16257606)
    worm
    (Caenorhabditis elegans)
    Secernentea prl-16
    Protein PRL-1
    47(a)
    1 → many
    X(3940141-3943315)


    ENSEMBL Gene Tree for PTP4A3 (if available)
    TreeFam Gene Tree for PTP4A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTP4A3 gene
    PTP4A12  PTP4A22  
    2 SIMAP similar genes for PTP4A3 using alignment to 3 protein entries:     TP4A3_HUMAN (see all proteins):
    PTP4A2    PTP4A1

    PTP4A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/379 SNPs in PTP4A3 are shown (see all 379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126809691,2
    C,F--142430036(+) TGTGGC/TGGCTG 2 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs74602621,2
    C,F,A,H--142430086(+) AGGGCA/TGGCAG 2 -- us2k111Minor allele frequency- T:0.20EA NS NA WA 662
    rs1897411231,2
    --142430407(+) GGACCC/TCTCAG 2 -- us2k10--------
    rs1495287671,2
    C--142430415(+) CAGCAA/GCAGTG 2 -- us2k10--------
    rs784250731,2
    C,F--142430457(+) CCTCAT/GCGTGC 2 -- us2k13Minor allele frequency- G:0.08WA NA EA 358
    rs1181733341,2
    F--142430469(+) CATGGG/TGTAAC 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs774989261,2
    F--142430493(+) CCTTGC/GTCAAG 2 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1813069541,2
    --142430515(+) CTTCCA/GTAGAG 2 -- us2k10--------
    rs1853628071,2
    --142430656(+) CAGGGC/TCCTGT 2 -- us2k10--------
    rs1441282561,2
    --142430688(+) GCCACA/CTGTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTP4A3 (142402093 - 142441620 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for PTP4A3 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737782CNV Deletion23290073
    esv2737756CNV Deletion23290073
    esv1420349CNV Insertion17803354
    nsv6431CNV Insertion18451855
    esv1265503CNV Insertion17803354
    esv1229387CNV Insertion17803354
    esv1011203CNV Insertion20482838
    nsv509285CNV Insertion20534489
    dgv7900n71CNV Loss21882294
    nsv891569CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing PTP4A3:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing PTP4A3
    DNA2.0 Custom Variant and Variant Library Synthesis for PTP4A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606449    OMIM disorders: --

    18 diseases for PTP4A3:    About MalaCards
    esophageal squamous cell carcinoma    colon adenocarcinoma    nasopharyngitis    endometriosis
    esophagitis    lung cancer    squamous cell carcinoma    gastric cancer
    cholangiocarcinoma    colon cancer    colorectal cancer    myeloma
    adenocarcinoma    hepatocellular carcinoma    ovarian cancer    endotheliitis
    melanoma    breast cancer


    PTP4A3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for PTP4A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 14 4 15161639 (2), 17717498 (1), 15788667 (1)
    tumors 4.65 1 15161639 (1)


    Export disorders for PTP4A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTP4A3 gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with PTP4A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. (PubMed id 11355880)1, 2, 9 Matter W.F.... Vlahos C.J. (2001)
    2. Structural insights into molecular function of the metastasis- associated phosphatase PRL-3. (PubMed id 14704153)1, 2 Kozlov G.... Ekiel I. (2004)
    3. Structure of human PRL-3, the phosphatase associated with cancer metastasis. (PubMed id 15135076)1, 2 Kim K.-A.... Cheong C. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. (PubMed id 12782572)1, 2 Zeng Q.... Hong W. (2003)
    6. The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. (PubMed id 12235145)1, 2 Wang J.... Herbst R. (2002)
    7. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. (PubMed id 12516958)1, 2 Pathak M.K.... Yi T. (2002)
    8. A phosphatase associated with metastasis of colorectal cancer. (PubMed id 11598267)1, 2 Saha S....Vogelstein B. (2001)
    9. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. (PubMed id 9633825)1, 2 Dayton M.A. and Knobloch T.J. (1997)
    10. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. (PubMed id 15788667)1, 9 Li J....Zeng Q. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11156 HGNC: 9636 AceView: PTP4A3 Ensembl:ENSG00000184489 euGenes: HUgn11156
    ECgene: PTP4A3 H-InvDB: PTP4A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTP4A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTP4A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTP4A3 gene:
    Search GeneIP for patents involving PTP4A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PTP4A3
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PTP4A3 (PRL-3/PTP4A3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PTP4A3   OriGene RNAi products in human, mouse, rat for PTP4A3  
     OriGene qPCR primer pairs and template standards for PTP4A3   OriGene Protein Over-expression Lysate for PTP4A3  
     OriGene MassSpec something-or-other for PTP4A3   OriGene clones in human, mouse for PTP4A3  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTP4A3   OriGene Purified Protein for PTP4A3  
     OriGene ORF clones in mouse, rat for PTP4A3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTP4A3   OriGene Custom Protein Services for PTP4A3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTP4A3
     QIAGEN SeqTarget long-range PCR primers for resequencing PTP4A3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTP4A3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTP4A3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTP4A3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTP4A3
     GenScript Custom Purified and Recombinant Proteins Services for PTP4A3 GenScript cDNA clones with any tag delivered in your preferred vector for PTP4A3
     GenScript Custom Assay Services for PTP4A3 GenScript Custom Superior Antibodies Services for PTP4A3
     GenScript Custom overexpressing Cell Line Services for PTP4A3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PTP4A3 promoter
     Search Chromatin IP Primers for PTP4A3
     RT2 qPCR Primer Assay in human, mouse, rat PTP4A3
     GNC Network for PTP4A3
     SABiosciences PCR Arrays including human, mouse, rat PTP4A3
     Search Tocris compounds for PTP4A3 (TP4A3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PTP4A3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for PTP4A3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PTP4A3 antibodies
     PTP4A3 proteins
     PTP4A3 lysates
     Antibodies for PTP4A3
     See all of Abcam's Antibodies, Kits and Proteins for PTP4A3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PTP4A3




     Proteins for PTP4A3
     Antibodies for PTP4A3
     ELISAs for PTP4A3
     CLIAs for PTP4A3
     Search LifeMap BioReagents cell lines for PTP4A3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTP4A3
     SwitchGear 3'UTR luciferase reporter plasmids for PTP4A3
     SwitchGear Promoter luciferase reporter plasmids for PTP4A3
     ThermoFisher Antibodies for PTP4A3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTP4A3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PTP4A3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTP4A3
    Customized:
     lentivirus for stable overexpression of PTP4A3
     lentivirus expression plasmids for stable overexpression of PTP4A3
     adenovirus for overexpression of PTP4A3
     LSBio Antibodies in human, mouse, rat for PTP4A3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PTP4A3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4