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PTP4A3 Gene

protein-coding   GIFtS: 59
GCID: GC08P142432

Protein Tyrosine Phosphatase Type IVA, Member 3

  Search for PTP4A3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Phosphatase Type IVA, Member 31 2     PRL-R2 3
PRL32 3 5     EC 3.1.3.483 8
Protein-Tyrosine Phosphatase 4a32 3     Potentially Prenylated Protein Tyrosine Phosphatase2
Protein-Tyrosine Phosphatase Of Regenerating Liver 32 3     Protein Tyrosine Phosphatase Type IVA 32
PRL-32 3     

External Ids:    HGNC: 96361   Entrez Gene: 111562   Ensembl: ENSG000001844897   OMIM: 6064495   UniProtKB: O753653   

Export aliases for PTP4A3 gene to outside databases

Previous GC identifers: GC00U990504 GC08U900031 GC08P142111 GC08P142403 GC08P142501 GC08P137749


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTP4A3 Gene:
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell
signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of
protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association
with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene
has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2013)

GeneCards Summary for PTP4A3 Gene:
PTP4A3 (protein tyrosine phosphatase type IVA, member 3) is a protein-coding gene. GO annotations related to this gene include prenylated protein tyrosine phosphatase activity. An important paralog of this gene is PTP4A1.

UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances
cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the
progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II

Gene Wiki entry for PTP4A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PTP4A3 gene promoter:
         STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTP4A3 promoter sequence
   Search Chromatin IP Primers for PTP4A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTP4A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

PTP4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTP4A3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P142432:  view genomic region     (about GC identifiers)

Start:
142,402,093 bp from pter      End:
142,441,620 bp from pter
Size:
39,528 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365 (See protein sequence)
Recommended Name: Protein tyrosine phosphatase type IVA 3 precursor  
Size: 173 amino acids; 19535 Da
Subunit: Interacts with tubulin
3 PDB 3D structures from and Proteopedia for PTP4A3:
1R6H (3D)        1V3A (3D)        2MBC (3D)    
Secondary accessions: Q8IVN5 Q99849 Q9BTW5
Alternative splicing: 3 isoforms:  O75365-1   O75365-2   O75365-3   (Unstructured and inactive)

Explore the universe of human proteins at neXtProt for PTP4A3: NX_O75365

Explore proteomics data for PTP4A3 at MOPED

Post-translational modifications: 

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTP4A3 (O75365) (see all 6)
     GMKYEDA  YLEKYRPK  MRFLITHNP  QFIRQKRRGA 


    See PTP4A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_009010.2  NP_116000.1  

    ENSEMBL proteins: 
     ENSP00000428976   ENSP00000428758   ENSP00000428725   ENSP00000430332   ENSP00000332274  
     ENSP00000331730  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPP: Protein tyrosine phosphatases / Class I Cys-based PTPs : PRLs

    2 InterPro protein domains:
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry O75365

    ProtoNet protein and cluster: O75365

    UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with PTP4A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TP4A3_HUMAN, O75365
    Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances
    cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the
    progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity ----
    GO:0004727prenylated protein tyrosine phosphatase activity TAS9514946
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with PTP4A3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTP4A3:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ptp4a3):
     growth/size/body  homeostasis/metabolism  mortality/aging  no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with PTP4A3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ptp4a3tm1.1Geh for PTP4A3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTP4A3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTP4A3

    miRNA
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    miRTarBase miRNAs that target PTP4A3:
    hsa-mir-192-5p (MIRT004166)

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    4 qRT-PCR Assays for microRNAs that regulate PTP4A3:
    hsa-miR-140-5p hsa-miR-18a hsa-miR-137 hsa-miR-18b
    SwitchGear 3'UTR luciferase reporter plasmidPTP4A3 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PTP4A3 

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    eBioscience FlowRNA Probe Sets ( VA1-11425) for PTP4A3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TP4A3_HUMAN, O75365: Cell membrane. Early endosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytosol2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with PTP4A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTP4A3 About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Signaling events mediated by PRL
    Signaling events mediated by PRL

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTP4A3
        Epithelial Adherens Junctions

    1 BioSystems Pathway for PTP4A3
        Signaling events mediated by PRL



        Pathway & Disease-focused RT2 Profiler PCR Array including PTP4A3: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTP4A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTP4A3 (O753653 ENSP000003322744) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNTAP493543, ENSP000003034234I2D: score=3 STRING: ENSP00000303423
    FNTBP493563, ENSP000002461664I2D: score=3 STRING: ENSP00000246166
    MSH2P432463, ENSP000002331464I2D: score=2 STRING: ENSP00000233146
    NCAPGQ9BPX33, ENSP000002514964I2D: score=2 STRING: ENSP00000251496
    RAB3GAP2Q9H2M93, ENSP000003518324I2D: score=2 STRING: ENSP00000351832
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS9514946

    Find genes that share ontologies with PTP4A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTP4A3 (TP4A3)

    4 HMDB Compounds for PTP4A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    SodiumSodium (see all 2)7440-23-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTP4A3 gene (2 alternative transcripts): 
    NM_007079.3  NM_032611.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521578(uc010mes.3) ENST00000520105 ENST00000523147 ENST00000524028
    ENST00000329397(uc003ywg.1 uc010met.1) ENST00000349124(uc003ywh.1)

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    4 qRT-PCR Assays for microRNAs that regulate PTP4A3:
    hsa-miR-140-5p hsa-miR-18a hsa-miR-137 hsa-miR-18b
    SwitchGear 3'UTR luciferase reporter plasmidPTP4A3 3' UTR sequence
    Inhib. RNA
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    eBioscience FlowRNA Probe Sets ( VA1-11425) for PTP4A3 

    Selected AceView cDNA sequences (see all 192):

    T19182 BX439784 AL542316 AJ572627 CK819091 NM_032611 BM790933 AL550979 
    U87168 BM708902 BM791220 BM701686 AW189182 AJ572032 BQ637038 BC003105 
    NM_007079 BQ639361 AA454501 BQ637188 AL528298 F18085 BM751125 BM127235 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A3    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                       -                           
    SP2:                                -                           
    SP3:                                -           -               
    SP4:                                                            


    ECgene alternative splicing isoforms for PTP4A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTP4A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGTCAGGA
    PTP4A3 Expression
    About this image


    PTP4A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Liver (Hepatobiliary System)
     
     Skeletal Muscle (Muscoskeletal System)
    PTP4A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTP4A3 Protein Expression

    UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
    Tissue specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently
    overexpressed in colon cancer metastasis

        Pathway & Disease-focused RT2 Profiler PCR Array including PTP4A3: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTP4A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTP4A3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptp4a31 , 5 protein tyrosine phosphatase 4a31, 5 88.63(n)1
    96.53(a)1
      15 (34.05 cM)5
    192451  NM_001166388.11  NP_001159860.11 
     737231455 
    chicken
    (Gallus gallus)
    Aves PTP4A31 protein tyrosine phosphatase type IVA, member 3 82.85(n)
    91.33(a)
      768713  XM_001231578.3  XP_001231579.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTP4A36
    protein tyrosine phosphatase type IVA, member 3
    90(a)
    1 ↔ 1
    4(14931279-15001838)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptp4a31 protein tyrosine phosphatase type IVA, member 3 77.65(n)
    89.02(a)
      100216017  NM_001142008.2  NP_001135480.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc54b052 wufc54b05 79.03(n)   325062  CB358392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PRL-16
    PRL-1
    54(a)
    1 → many
    2L(16245835-16257606)
    worm
    (Caenorhabditis elegans)
    Secernentea T19D2.26
    Protein PRL-1 (prl-1) mRNA, complete cds
    47(a)
    1 → many
    X(3940141-3943313) WBGene00004184


    ENSEMBL Gene Tree for PTP4A3 (if available)
    TreeFam Gene Tree for PTP4A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTP4A3 gene
    PTP4A12  PTP4A22  
    2 SIMAP similar genes for PTP4A3 using alignment to 3 protein entries:     TP4A3_HUMAN (see all proteins):
    PTP4A2    PTP4A1

    Find genes that share paralogs with PTP4A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTP4A3 (see all 379)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126809691,2
    C,F--142430036(+) TGTGGC/TGGCTG 2 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs74602621,2
    C,F,A,H--142430086(+) AGGGCA/TGGCAG 2 -- us2k111Minor allele frequency- T:0.20EA NS NA WA 662
    rs1897411231,2
    --142430407(+) GGACCC/TCTCAG 2 -- us2k10--------
    rs1495287671,2
    C--142430415(+) CAGCAA/GCAGTG 2 -- us2k10--------
    rs784250731,2
    C,F--142430457(+) CCTCAT/GCGTGC 2 -- us2k13Minor allele frequency- G:0.08WA NA EA 358
    rs1181733341,2
    F--142430469(+) CATGGG/TGTAAC 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs774989261,2
    F--142430493(+) CCTTGC/GTCAAG 2 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1813069541,2
    --142430515(+) CTTCCA/GTAGAG 2 -- us2k10--------
    rs1853628071,2
    --142430656(+) CAGGGC/TCCTGT 2 -- us2k10--------
    rs1441282561,2
    --142430688(+) GCCACA/CTGTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTP4A3 (142402093 - 142441620 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTP4A3 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737782CNV Deletion23290073
    esv2737756CNV Deletion23290073
    esv1420349CNV Insertion17803354
    nsv6431CNV Insertion18451855
    esv1265503CNV Insertion17803354
    esv1229387CNV Insertion17803354
    esv1011203CNV Insertion20482838
    nsv509285CNV Insertion20534489
    dgv7900n71CNV Loss21882294
    nsv891569CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing PTP4A3:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing PTP4A3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606449    OMIM disorders: --


    Find genes that share disorders with PTP4A3           About GenesLikeMe

    2 Novoseek inferred disease relationships for PTP4A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 14 4 15161639 (2), 17717498 (1), 15788667 (1)
    tumors 4.65 1 15161639 (1)


    Export disorders for PTP4A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PTP4A3 gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with PTP4A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. (PubMed id 11355880)1, 2, 9 Matter W.F.... Vlahos C.J. (Biochem. Biophys. Res. Commun. 2001)
    2. Structural insights into molecular function of the metastasis- associated phosphatase PRL-3. (PubMed id 14704153)1, 2 Kozlov G.... Ekiel I. (J. Biol. Chem. 2004)
    3. Structure of human PRL-3, the phosphatase associated with cancer metastasis. (PubMed id 15135076)1, 2 Kim K.-A.... Cheong C. (FEBS Lett. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. (PubMed id 12782572)1, 2 Zeng Q.... Hong W. (Cancer Res. 2003)
    6. The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. (PubMed id 12235145)1, 2 Wang J.... Herbst R. (J. Biol. Chem. 2002)
    7. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. (PubMed id 12516958)1, 2 Pathak M.K.... Yi T. (Mol. Cancer Ther. 2002)
    8. A phosphatase associated with metastasis of colorectal cancer. (PubMed id 11598267)1, 2 Saha S....Vogelstein B. (Science 2001)
    9. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. (PubMed id 9633825)1, 2 Dayton M.A. and Knobloch T.J. (Recept. Signal Transduct. 1997)
    10. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. (PubMed id 15788667)1, 9 Li J....Zeng Q. (Clin. Cancer Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 11156 HGNC: 9636 AceView: PTP4A3 Ensembl:ENSG00000184489 euGenes: HUgn11156
    ECgene: PTP4A3 H-InvDB: PTP4A3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PTP4A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTP4A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PTP4A3 gene:
    Search GeneIP for patents involving PTP4A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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