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Aliases for PTP4A3 Gene

Aliases for PTP4A3 Gene

  • Protein Tyrosine Phosphatase Type IVA, Member 3 2 3 5
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 3 3 4
  • Protein-Tyrosine Phosphatase 4a3 3 4
  • EC 3.1.3.48 4 63
  • PRL-R 3 4
  • PRL-3 3 4
  • PRL3 3 4
  • Potentially Prenylated Protein Tyrosine Phosphatase 3

External Ids for PTP4A3 Gene

Previous GeneCards Identifiers for PTP4A3 Gene

  • GC00U990504
  • GC08U900031
  • GC08P142111
  • GC08P142403
  • GC08P142501
  • GC08P142432
  • GC08P137749

Summaries for PTP4A3 Gene

Entrez Gene Summary for PTP4A3 Gene

  • This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTP4A3 Gene

PTP4A3 (Protein Tyrosine Phosphatase Type IVA, Member 3) is a Protein Coding gene. Diseases associated with PTP4A3 include Uveal Melanoma. Among its related pathways are p53 Pathway (RnD) and PAK Pathway. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A1.

UniProtKB/Swiss-Prot for PTP4A3 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Gene Wiki entry for PTP4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTP4A3 Gene

Genomics for PTP4A3 Gene

Regulatory Elements for PTP4A3 Gene

Enhancers for PTP4A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTP4A3 on UCSC Golden Path with GeneCards custom track

Promoters for PTP4A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTP4A3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PTP4A3 gene promoter:

Genomic Location for PTP4A3 Gene

Chromosome:
8
Start:
141,391,993 bp from pter
End:
141,432,454 bp from pter
Size:
40,462 bases
Orientation:
Plus strand

Genomic View for PTP4A3 Gene

Genes around PTP4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A3 Gene

Proteins for PTP4A3 Gene

  • Protein details for PTP4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75365-TP4A3_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 3
    Protein Accession:
    O75365
    Secondary Accessions:
    • Q8IVN5
    • Q99849
    • Q9BTW5

    Protein attributes for PTP4A3 Gene

    Size:
    173 amino acids
    Molecular mass:
    19535 Da
    Quaternary structure:
    • Interacts with tubulin.

    Three dimensional structures from OCA and Proteopedia for PTP4A3 Gene

    Alternative splice isoforms for PTP4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTP4A3 Gene

Proteomics data for PTP4A3 Gene at MOPED

Selected DME Specific Peptides for PTP4A3 Gene

Post-translational modifications for PTP4A3 Gene

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTP4A3 Gene

Antibody Products

  • R&D Systems Antibodies for PTP4A3 (PRL-3/PTP4A3)
  • Cell Signaling Technology (CST) Antibodies for PTP4A3 (PTP4A3)

Domains & Families for PTP4A3 Gene

Gene Families for PTP4A3 Gene

Protein Domains for PTP4A3 Gene

Suggested Antigen Peptide Sequences for PTP4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75365

UniProtKB/Swiss-Prot:

TP4A3_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A3: view

Function for PTP4A3 Gene

Molecular function for PTP4A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.
UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Enzyme Numbers (IUBMB) for PTP4A3 Gene

genes like me logo Genes that share phenotypes with PTP4A3: view

Animal Models for PTP4A3 Gene

MGI Knock Outs for PTP4A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTP4A3

CRISPR Products

miRNA for PTP4A3 Gene

miRTarBase miRNAs that target PTP4A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTP4A3 Gene

Localization for PTP4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A3 Gene

Cell membrane. Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTP4A3 Gene COMPARTMENTS Subcellular localization image for PTP4A3 gene
Compartment Confidence
plasma membrane 4
endosome 3
nucleus 3
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PTP4A3: view

Pathways & Interactions for PTP4A3 Gene

genes like me logo Genes that share pathways with PTP4A3: view

Pathways by source for PTP4A3 Gene

1 BioSystems pathway for PTP4A3 Gene
1 R&D Systems pathway for PTP4A3 Gene
1 Qiagen pathway for PTP4A3 Gene

Gene Ontology (GO) - Biological Process for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 9514946
GO:0043542 endothelial cell migration IMP 24403062
genes like me logo Genes that share ontologies with PTP4A3: view

No data available for SIGNOR curated interactions for PTP4A3 Gene

Drugs & Compounds for PTP4A3 Gene

(1) Drugs for PTP4A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for PTP4A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PTP4A3: view

Transcripts for PTP4A3 Gene

Unigene Clusters for PTP4A3 Gene

Protein tyrosine phosphatase type IVA, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PTP4A3 Gene

GeneLoc Exon Structure for
PTP4A3
ECgene alternative splicing isoforms for
PTP4A3

Expression for PTP4A3 Gene

mRNA expression in normal human tissues for PTP4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTP4A3 Gene

This gene is overexpressed in Muscle - Skeletal (x7.8), Heart - Left Ventricle (x7.7), and Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for PTP4A3 Gene

This gene is overexpressed in Retina (36.0), Heart (24.2), and Monocytes (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTP4A3 Gene



SOURCE GeneReport for Unigene cluster for PTP4A3 Gene Hs.744870

mRNA Expression by UniProt/SwissProt for PTP4A3 Gene

O75365-TP4A3_HUMAN
Tissue specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
genes like me logo Genes that share expression patterns with PTP4A3: view

Protein tissue co-expression partners for PTP4A3 Gene

Primer Products

Orthologs for PTP4A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTP4A3 35
  • 89.98 (n)
  • 94.22 (a)
PTP4A3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTP4A3 35
  • 89.4 (n)
  • 95.38 (a)
PTP4A3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptp4a3 35
  • 88.63 (n)
  • 96.53 (a)
Ptp4a3 16
Ptp4a3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTP4A3 35
  • 99.04 (n)
  • 99.42 (a)
PTP4A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptp4a3 35
  • 88.44 (n)
  • 96.53 (a)
oppossum
(Monodelphis domestica)
Mammalia PTP4A3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A3 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTP4A3 35
  • 82.85 (n)
  • 91.33 (a)
PTP4A3 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTP4A3 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptp4a3 35
  • 77.65 (n)
  • 89.02 (a)
zebrafish
(Danio rerio)
Actinopterygii ptp4a3 35
  • 77.65 (n)
  • 87.28 (a)
wufc54b05 35
PTP4A3 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta PRL-1 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T19D2.2 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10622 36
  • 66 (a)
OneToMany
Species with no ortholog for PTP4A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTP4A3 Gene

ENSEMBL:
Gene Tree for PTP4A3 (if available)
TreeFam:
Gene Tree for PTP4A3 (if available)

Paralogs for PTP4A3 Gene

Paralogs for PTP4A3 Gene

(2) SIMAP similar genes for PTP4A3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTP4A3: view

Variants for PTP4A3 Gene

Sequence variations from dbSNP and Humsavar for PTP4A3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7832913 -- 141,413,871(-) GTCCA(C/T)ACCGC intron-variant, upstream-variant-2KB
rs7835177 -- 141,429,096(+) CCCCA(A/G)CGACT intron-variant
rs7839136 -- 141,429,602(+) AGGGT(A/G)AGCGC intron-variant
rs7839591 -- 141,429,889(+) GGACC(A/C)GGTGG intron-variant
rs7841561 -- 141,426,813(+) GTCTG(C/T)TGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTP4A3 Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV Deletion 23290073
dgv7895n71 CNV Loss 21882294
nsv465956 CNV Gain 19166990
dgv7896n71 CNV Loss 21882294
nsv470240 CNV Loss 18288195
dgv7897n71 CNV Loss 21882294
nsv509285 CNV Insertion 20534489
nsv465958 CNV Loss 19166990
nsv891565 CNV Loss 21882294
nsv465959 CNV Loss 19166990
dgv7898n71 CNV Loss 21882294
nsv891569 CNV Loss 21882294
esv1011203 CNV Insertion 20482838
nsv6431 CNV Insertion 18451855
nsv824751 CNV Gain 20364138
dgv7899n71 CNV Loss 21882294
dgv902n27 CNV Loss 19166990
dgv7900n71 CNV Loss 21882294
esv2737782 CNV Deletion 23290073
esv22902 CNV Loss 19812545
esv1265503 CNV Insertion 17803354
esv1420349 CNV Insertion 17803354
esv1229387 CNV Insertion 17803354
nsv891577 CNV Gain 21882294

Variation tolerance for PTP4A3 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTP4A3 Gene

Disorders for PTP4A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTP4A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTP4A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTP4A3
genes like me logo Genes that share disorders with PTP4A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTP4A3 Gene

Publications for PTP4A3 Gene

  1. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. (PMID: 11355880) Matter W.F. … Vlahos C.J. (Biochem. Biophys. Res. Commun. 2001) 3 4 23 67
  2. Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer. (PMID: 17717498) Yamashita S. … Kawahara K. (Ann Thorac Cardiovasc Surg 2007) 3 23
  3. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. (PMID: 15788667) Li J. … Zeng Q. (Clin. Cancer Res. 2005) 3 23
  4. Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. (PMID: 15161639) Wu X. … Xu Q. (Am. J. Pathol. 2004) 3 23
  5. Methylation-associated silencing of miR-495 inhibit the migration and invasion of human gastric cancer cells by directly targeting PRL-3. (PMID: 25475733) Li Z. … Tan S. (Biochem. Biophys. Res. Commun. 2015) 3

Products for PTP4A3 Gene

Sources for PTP4A3 Gene

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