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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTP4A3 Gene

protein-coding   GIFtS: 63
GCID: GC08P142432

protein tyrosine phosphatase type IVA, member 3
 Explore 19 diseases affiliated with
PTP4A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTP4A3    

Aliases
for PTP4A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Phosphatase Type IVA, Member 31 2     Protein-Tyrosine Phosphatase Of Regenerating Liver 32 3
PRL31 2 3 5     EC 3.1.3.483 8
PRL-31 2 3     Potentially Prenylated Protein Tyrosine Phosphatase2
PRL-R1 2 3     Protein Tyrosine Phosphatase Type IVA 32
Protein-Tyrosine Phosphatase 4a32 3     

External Ids:    HGNC: 96361   Entrez Gene: 111562   Ensembl: ENSG000001844897   OMIM: 6064495   UniProtKB: O753653   

Export aliases for PTP4A3 gene to outside databases

Previous GC identifers: GC00U990504 GC08U900031 GC08P142111 GC08P142403 GC08P142501 GC08P137749


Summaries
for PTP4A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTP4A3:
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are
cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a
PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that
they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of
this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell
growth. Two alternatively spliced variants exist. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell
proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression
of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II

Gene Wiki entry for PTP4A3


Genomic Views
for PTP4A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTP4A3 gene promoter:
         STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTP4A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTP4A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTP4A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

PTP4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTP4A3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P142432:  view genomic region     (about GC identifiers)

Start:
 142,402,093 bp from pter      End:
 142,441,620 bp from pter
Size:
 39,528 bases      Orientation:
 plus strand

Proteins
for PTP4A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365 (See protein sequence)
Recommended Name: Protein tyrosine phosphatase type IVA 3 precursor  
Size: 173 amino acids; 19535 Da
Subunit: Interacts with tubulin
Subcellular location: Cell membrane. Early endosome
2 PDB 3D structures from and Proteopedia for PTP4A3:
1R6H (3D)        1V3A (3D)    
Secondary accessions: Q8IVN5 Q99849 Q9BTW5
Alternative splicing: 3 isoforms:  O75365-1   O75365-2   O75365-3   (Unstructured and inactive)

Explore the universe of human proteins at neXtProt for PTP4A3: NX_O75365

Post-translational modifications:

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75365

    • 4/6 DME Specific Peptides for PTP4A3 (O75365) (see all 6)
     GMKYEDA  YLEKYRPK  MRFLITHNP  QFIRQKRRGA 

    PTP4A3 Protein expression data from MOPED and PaxDb:    About this image 
    PTP4A3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_009010.2  NP_116000.1  

    ENSEMBL proteins: 
     ENSP00000428976   ENSP00000428758   ENSP00000428725   ENSP00000430332   ENSP00000332274  
     ENSP00000331730  

    Human Recombinant Protein Products for PTP4A3: 
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    Novus Biologicals PTP4A3 Proteins
    Novus Biologicals PTP4A3 Lysates
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    ProSpec Recombinant Protein for PTP4A3
    Uscn Proteins for PTP4A3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane IEA--

    PTP4A3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PTP4A3

    Protein Domains /
    Families
    for PTP4A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTP4A3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000242 Tyr_Pase_rcpt/non-rcpt
     IPR000387 Tyr/Dual-sp_Pase

    Graphical View of Domain Structure for InterPro Entry O75365

    ProtoNet protein and cluster: O75365

    UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for PTP4A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TP4A3_HUMAN, O75365
    Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell
    proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression
    of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004727prenylated protein tyrosine phosphatase activity TAS9514946
         
    PTP4A3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PTP4A3:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ptp4a3):
     no phenotypic analysis 

    PTP4A3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PTP4A3 

    miRNA
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    hsa-mir-192 (MIRT004166)

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    hsa-miR-140-5p hsa-miR-18a hsa-miR-137 hsa-miR-18b
    SwitchGear 3'UTR luciferase reporter plasmid: PTP4A3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for PTP4A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling events mediated by PRL
    		Signaling events mediated by PRL1.00
    2PAK Pathway
    		Epithelial Adherens Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTP4A3
        Epithelial Adherens Junctions

    1 BioSystems Pathway for PTP4A3 
        Signaling events mediated by PRL


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTP4A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/116 Interacting proteins for PTP4A3 (O753653 ENSP000003322744) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNTAP493543, ENSP000003034234I2D: score=3 STRING: ENSP00000303423
    FNTBP493563, ENSP000002461664I2D: score=3 STRING: ENSP00000246166
    MSH2P432463, ENSP000002331464I2D: score=2 STRING: ENSP00000233146
    NCAPGQ9BPX33, ENSP000002514964I2D: score=2 STRING: ENSP00000251496
    RAB3GAP2Q9H2M93, ENSP000003518324I2D: score=2 STRING: ENSP00000351832
    About this table

    Drugs & Compounds
    for PTP4A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PTP4A3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTP4A3

    4 HMDB Compounds for PTP4A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    SodiumSodium (see all 2)7440-23-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about PTP4A3 / TP4A3 

    Transcripts
    for PTP4A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTP4A3 gene (2 alternative transcripts): 
    NM_007079.2  NM_032611.1  

    Unigene Cluster for PTP4A3:

    Protein tyrosine phosphatase type IVA, member 3
    Hs.43666  [show with all ESTs]
    Unigene Representative Sequence: AK128380
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521578(uc010mes.3) ENST00000520105 ENST00000523147 ENST00000524028
    ENST00000329397(uc003ywg.1 uc010met.1) ENST00000349124(uc003ywh.1)


    miRNA
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    hsa-miR-140-5p hsa-miR-18a hsa-miR-137 hsa-miR-18b
    SwitchGear 3'UTR luciferase reporter plasmid: PTP4A3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF041434.1 AJ276554.1 AK128380.1 AY819648.1 BC003105.1 BT007303.1 U87168.1 

    9 DOTS entries:

    DT.100027011  DT.86855102  DT.407646  DT.100802459  DT.40133000  DT.100783221  DT.97827688  DT.121489739 
    DT.86855103 

    24/192 AceView cDNA sequences (see all 192):

    BM708902 T19182 BM701686 AW189182 U87168 CK819091 NM_007079 BM790933 
    AL542316 AL528298 BQ637188 AJ572032 BX439784 BQ637038 BC003105 BM791220 
    AA454501 BQ639361 AJ572627 NM_032611 AL550979 AL574689 BQ881257 BE778111 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A3    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                       -                           
    SP2:                                -                           
    SP3:                                -           -               
    SP4:                                                            


    ECgene alternative splicing isoforms for PTP4A3

    Expression
    for PTP4A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTP4A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGTCAGGA
    PTP4A3 Expression
    About this image

    PTP4A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTP4A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTP4A3

    SOURCE GeneReport for Unigene cluster: Hs.43666

    UniProtKB/Swiss-Prot: TP4A3_HUMAN, O75365
    Tissue specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently
    overexpressed in colon cancer metastasis

        SABiosciences Expression via Pathway-Focused PCR Array including PTP4A3: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PTP4A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTP4A3 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ptp4a31 , 5 protein tyrosine phosphatase 4a31, 5 88.44(n)1
    96.53(a)1    		   15 (34.05 cM)5
    192451  NM_001166388.11  NP_001159860.11 
     737231455 
    chicken
    (Gallus gallus)    		 Aves PTP4A31 protein tyrosine phosphatase type IVA, member 3 82.85(n)
    91.33(a)    		   768713  XM_001231578.2  XP_001231579.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PTP4A36
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(14982135-15001237)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc54b052 wufc54b05 79.03(n)   325062  CB358392.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta PRL-16
    		 PRL-1
    		 55(a)
    		 1 → many
    		 2L(16245835-16257606)
    worm
    (Caenorhabditis elegans)    		 Secernentea prl-16
    		 Protein PRL-1; Putative prenylated protein tyrosin...
    		 47(a)
    		 1 → many
    		 X(3940121-3943295)


    ENSEMBL Gene Tree for PTP4A3 (if available)
    TreeFam Gene Tree for PTP4A3 (if available) 

    Paralogs
    for PTP4A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTP4A3 gene
    PTP4A12  PTP4A22  
    2 SIMAP similar genes for PTP4A3 using alignment to 3 protein entries:     TP4A3_HUMAN (see all proteins):
    PTP4A2    PTP4A1

    PTP4A3 for paralogs           About GeneDecksing



    Genomic Variants
    for PTP4A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/298 NCBI SNPs in PTP4A3 are shown (see all 298)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1126809691,2
    		F--142430036(+) TGTGGC/TGGCTG 2 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs74602621,2
    		C,F,A,H--142430086(+) AGGGCA/TGGCAG 2 -- us2k111Minor allele frequency- T:0.20EA NS NA WA 662
    rs1897411231,2
    		--142430407(+) GGACCC/TCTCAG 2 -- us2k10--------
    rs1495287671,2
    		--142430415(+) CAGCAA/GCAGTG 2 -- us2k10--------
    rs784250731,2
    		C,F--142430457(+) CCTCAT/GCGTGC 2 -- us2k13Minor allele frequency- G:0.08WA NA EA 358
    rs1181733341,2
    		--142430469(+) CATGGG/TGTAAC 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs774989261,2
    		F--142430493(+) CCTTGC/GTCAAG 2 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1813069541,2
    		--142430515(+) CTTCCA/GTAGAG 2 -- us2k10--------
    rs1853628071,2
    		--142430656(+) CAGGGC/TCCTGT 2 -- us2k10--------
    rs1441282561,2
    		--142430688(+) GCCACA/CTGTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTP4A3 (142402093 - 142441620 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for PTP4A3
         5 CNVs: 30289 36766 36767 53637 30288
         1 Indel: 70456

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing PTP4A3:
    Ovarian Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTP4A3
    DNA2.0 Custom Variant and Variant Library Synthesis for PTP4A3

    Disorders / Diseases
    for PTP4A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTP4A3 for disorders           About GeneDecksing

    OMIM gene information: 606449    OMIM disorders: --

    19 diseases for PTP4A3:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    colon adenocarcinoma    hepatocellular carcinoma
    esophagitis    endometriosis    colon cancer    gastric cancer
    ovarian cancer    nasopharyngitis    colorectal cancer    cholangiocarcinoma
    lung cancer    adenocarcinoma    carcinoma    breast cancer
    myeloma    melanoma    malaria

    2 Novoseek disease relationships for PTP4A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 14 4 15161639 (2), 17717498 (1), 15788667 (1)
    tumors 4.65 1 15161639 (1)


    Export disorders for PTP4A3 gene to outside databases

    Publications
    for PTP4A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTP4A3 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with PTP4A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. (PubMed id 11355880)1, 2, 9 Matter W.F.... Vlahos C.J. (2001)
    2. Structural insights into molecular function of the metastasis- associated phosphatase PRL-3. (PubMed id 14704153)1, 2 Kozlov G.... Ekiel I. (2004)
    3. Structure of human PRL-3, the phosphatase associated with cancer metastasis. (PubMed id 15135076)1, 2 Kim K.-A.... Cheong C. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. (PubMed id 12782572)1, 2 Zeng Q.... Hong W. (2003)
    6. The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. (PubMed id 12235145)1, 2 Wang J.... Herbst R. (2002)
    7. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. (PubMed id 12516958)1, 2 Pathak M.K.... Yi T. (2002)
    8. A phosphatase associated with metastasis of colorectal cancer. (PubMed id 11598267)1, 2 Saha S....Vogelstein B. (2001)
    9. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. (PubMed id 9633825)1, 2 Dayton M.A. and Knobloch T.J. (1997)
    10. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. (PubMed id 15788667)1, 9 Li J....Zeng Q. (2005)

    External Searches for PTP4A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTP4A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11156 HGNC: 9636 AceView: PTP4A3 Ensembl:ENSG00000184489 euGenes: HUgn11156
    ECgene: PTP4A3 H-InvDB: PTP4A3

    Other Databases showing PTP4A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTP4A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTP4A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTP4A3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTP4A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTP4A3 gene:
    Search GeneIP for patents involving PTP4A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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