Aliases for PTP4A2 Gene
External Ids for PTP4A2 Gene
Previous HGNC Symbols for PTP4A2 Gene
Previous GeneCards Identifiers for PTP4A2 Gene
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
GeneCards Summary for PTP4A2 Gene
PTP4A2 (Protein Tyrosine Phosphatase Type IVA, Member 2) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and PAK Pathway. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A1.
UniProtKB/Swiss-Prot for PTP4A2 Gene
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.