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Aliases for PTP4A2 Gene

Aliases for PTP4A2 Gene

  • Protein Tyrosine Phosphatase Type IVA, Member 2 2 3 5
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 2 3 4
  • Protein-Tyrosine Phosphatase 4a2 3 4
  • PTP(CAAXII) 3 4
  • EC 3.1.3.48 4 61
  • PTPCAAX2 3 4
  • HU-PP-1 3 4
  • PRL-2 3 4
  • OV-1 3 4
  • PRL2 3 4
  • Protein Tyrosine Phosphatase Type IVA 2 3
  • Phosphatase Of Regenerating Liver 2 3
  • Protein Tyrosine Phosphatase IVA2 3
  • Protein Tyrosine Phosphatase IVA 3
  • Ptp-IV1a 3
  • Ptp-IV1b 3
  • HH7-2 3
  • PTP4A 3
  • HH13 3

External Ids for PTP4A2 Gene

Previous HGNC Symbols for PTP4A2 Gene

  • PTP4A

Previous GeneCards Identifiers for PTP4A2 Gene

  • GC01M032182
  • GC01M031359
  • GC01M031798
  • GC01M032041
  • GC01M032372
  • GC01M030488

Summaries for PTP4A2 Gene

Entrez Gene Summary for PTP4A2 Gene

  • The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

GeneCards Summary for PTP4A2 Gene

PTP4A2 (Protein Tyrosine Phosphatase Type IVA, Member 2) is a Protein Coding gene. Diseases associated with PTP4A2 include Myopathy, Centronuclear. Among its related pathways are Signaling events mediated by PRL and RAB geranylgeranylation. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A1.

UniProtKB/Swiss-Prot for PTP4A2 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Gene Wiki entry for PTP4A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTP4A2 Gene

Genomics for PTP4A2 Gene

Regulatory Elements for PTP4A2 Gene

Enhancers for PTP4A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G031845 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +97.0 96984 5.0 HDGF YBX3 CBX3 ARNT CHAMP1 RARA ZNF121 ZNF366 BCLAF1 ZNF263 PTP4A2 MTMR9LP SPOCD1 LCK SYNC ENSG00000203620
GH01G031842 1.4 Ensembl ENCODE dbSUPER 11.2 +101.3 101312 1.3 HDAC1 PKNOX1 ARNT ZBTB40 CHAMP1 TCF12 SMARCA5 NCOA1 CEBPB ZEB2 PTP4A2 PEF1 SYNC ENSG00000203620 SPOCD1
GH01G031920 1.2 Ensembl ENCODE dbSUPER 12.5 +22.2 22157 3.4 FOXA2 ZKSCAN1 ZEB1 FOXM1 ZNF121 ZNF366 POLR2A RFX1 ATF2 POLR2H PTP4A2 KHDRBS1 SPOCD1 ENSG00000269967 ENSG00000228634
GH01G031980 1.3 Ensembl ENCODE 11.4 -37.1 -37126 2.5 FOXA2 PKNOX1 ATF1 ARID4B ZNF48 ZNF2 GLIS2 ELK1 ZNF143 REST KHDRBS1 PTP4A2
GH01G031912 1.1 ENCODE dbSUPER 11.8 +32.1 32131 1.2 PKNOX1 TBL1XR1 BMI1 FEZF1 RELB IKZF2 CREM SMAD5 CBFB JUNB PTP4A2 SPOCD1 GC01M031906 ENSG00000269967
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTP4A2 on UCSC Golden Path with GeneCards custom track

Promoters for PTP4A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004288 156 601 HDGF CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for PTP4A2 Gene

Chromosome:
1
Start:
31,906,421 bp from pter
End:
31,944,856 bp from pter
Size:
38,436 bases
Orientation:
Minus strand

Genomic View for PTP4A2 Gene

Genes around PTP4A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A2 Gene

Proteins for PTP4A2 Gene

  • Protein details for PTP4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12974-TP4A2_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 2
    Protein Accession:
    Q12974
    Secondary Accessions:
    • A8K9I8
    • B4DM39
    • D3DPP0
    • E9PGJ6
    • O00649
    • Q15197
    • Q15259
    • Q15260
    • Q15261
    • R4GN50

    Protein attributes for PTP4A2 Gene

    Size:
    167 amino acids
    Molecular mass:
    19127 Da
    Quaternary structure:
    • In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.
    Miscellaneous:
    • A processed pseudogene with 96% sequence identity was found in the BRCA1 (113705) region of 17q21.

    Three dimensional structures from OCA and Proteopedia for PTP4A2 Gene

    Alternative splice isoforms for PTP4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTP4A2 Gene

Selected DME Specific Peptides for PTP4A2 Gene

Q12974:
  • DWPFDDGAPP
  • EELKKYGVTT
  • KFREEPGCC
  • HCVAGLGRAPVLVA
  • YLEKYRPK
  • MRFLITHNP
  • NQIVDDWL
  • QFIRQKRRGA
  • GMKYEDA

Post-translational modifications for PTP4A2 Gene

  • Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for PTP4A2

Domains & Families for PTP4A2 Gene

Gene Families for PTP4A2 Gene

Suggested Antigen Peptide Sequences for PTP4A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12974

UniProtKB/Swiss-Prot:

TP4A2_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A2: view

Function for PTP4A2 Gene

Molecular function for PTP4A2 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase 4A,member 2,homolog to rat PRL1 (regenerating liver protein tyrosine phosphatase 1),mainly expressed in nucleus
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and pentamidine.
UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Enzyme Numbers (IUBMB) for PTP4A2 Gene

Gene Ontology (GO) - Molecular Function for PTP4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004727 prenylated protein tyrosine phosphatase activity TAS 9514946
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTP4A2: view
genes like me logo Genes that share phenotypes with PTP4A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTP4A2

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTP4A2 Gene

Localization for PTP4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A2 Gene

Cell membrane. Early endosome. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTP4A2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
nucleus 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PTP4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IDA 10940933
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTP4A2: view

Pathways & Interactions for PTP4A2 Gene

genes like me logo Genes that share pathways with PTP4A2: view

Pathways by source for PTP4A2 Gene

1 BioSystems pathway for PTP4A2 Gene
1 Qiagen pathway for PTP4A2 Gene

Interacting Proteins for PTP4A2 Gene

SIGNOR curated interactions for PTP4A2 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTP4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PTP4A2: view

Drugs & Compounds for PTP4A2 Gene

(12) Drugs for PTP4A2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(7) Additional Compounds for PTP4A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with PTP4A2: view

Transcripts for PTP4A2 Gene

Unigene Clusters for PTP4A2 Gene

Protein tyrosine phosphatase type IVA, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6: -

Relevant External Links for PTP4A2 Gene

GeneLoc Exon Structure for
PTP4A2
ECgene alternative splicing isoforms for
PTP4A2

Expression for PTP4A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTP4A2 Gene

Protein differential expression in normal tissues from HIPED for PTP4A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Frontal cortex (6.7), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTP4A2 Gene



Protein tissue co-expression partners for PTP4A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTP4A2 Gene:

PTP4A2

SOURCE GeneReport for Unigene cluster for PTP4A2 Gene:

Hs.470477

mRNA Expression by UniProt/SwissProt for PTP4A2 Gene:

Q12974-TP4A2_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.

Evidence on tissue expression from TISSUES for PTP4A2 Gene

  • Nervous system(4.9)
  • Bone marrow(4.4)
  • Lung(3.6)
  • Liver(3)
  • Blood(2.8)
  • Eye(2.6)
  • Heart(2.5)
  • Intestine(2.5)
  • Spleen(2.4)
  • Muscle(2.3)
  • Kidney(2.1)
  • Lymph node(2.1)
  • Pancreas(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with PTP4A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A2 Gene

Orthologs for PTP4A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTP4A2 34 35
  • 99 (n)
oppossum
(Monodelphis domestica)
Mammalia PTP4A2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A2 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTP4A2 34 35
  • 96.81 (n)
cow
(Bos Taurus)
Mammalia PTP4A2 34 35
  • 96.21 (n)
mouse
(Mus musculus)
Mammalia Ptp4a2 34 16 35
  • 95.41 (n)
rat
(Rattus norvegicus)
Mammalia Ptp4a2 34
  • 92.81 (n)
chicken
(Gallus gallus)
Aves PTP4A2 34 35
  • 85.63 (n)
lizard
(Anolis carolinensis)
Reptilia PTP4A2 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptp4a2 34
  • 80.44 (n)
zebrafish
(Danio rerio)
Actinopterygii ptp4a2b 34 35
  • 75.25 (n)
ptp4a2a 35
  • 60 (a)
OneToMany
Dr.3996 34
fruit fly
(Drosophila melanogaster)
Insecta PRL-1 36 35
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea T19D2.2 35
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10622 35
  • 63 (a)
OneToMany
Species where no ortholog for PTP4A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTP4A2 Gene

ENSEMBL:
Gene Tree for PTP4A2 (if available)
TreeFam:
Gene Tree for PTP4A2 (if available)

Paralogs for PTP4A2 Gene

Paralogs for PTP4A2 Gene

(2) SIMAP similar genes for PTP4A2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PTP4A2 Gene

genes like me logo Genes that share paralogs with PTP4A2: view

Variants for PTP4A2 Gene

Sequence variations from dbSNP and Humsavar for PTP4A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000021497 -- 31,939,283(+) GGGAG(A/G)TTGAG intron-variant, upstream-variant-2KB
rs1000116051 -- 31,938,323(+) TTACA(A/G)CCCGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000197062 -- 31,914,945(+) GGAGG(A/G)GGATG intron-variant
rs1000233146 -- 31,914,620(+) CTCCA(G/T)TTCTC intron-variant
rs1000282597 -- 31,926,807(+) AGAAG(C/T)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTP4A2 Gene

Variant ID Type Subtype PubMed ID
dgv71n106 CNV deletion 24896259
esv2127776 CNV deletion 18987734
esv2746463 CNV deletion 23290073
esv2746475 CNV deletion 23290073
esv2758930 CNV loss 17122850
esv33582 CNV loss 17666407
esv3560360 CNV deletion 23714750
nsv1009817 CNV gain 25217958
nsv1076345 CNV deletion 25765185
nsv1144366 CNV deletion 24896259
nsv834591 CNV loss 17160897
nsv945868 CNV duplication 23825009
nsv947424 CNV duplication 23825009
nsv950583 CNV duplication 24416366

Variation tolerance for PTP4A2 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTP4A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTP4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A2 Gene

Disorders for PTP4A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTP4A2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
myopathy, centronuclear
  • centronuclear myopathy, autosomal, modifier of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTP4A2

Genetic Association Database (GAD)
PTP4A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTP4A2
genes like me logo Genes that share disorders with PTP4A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTP4A2 Gene

Publications for PTP4A2 Gene

  1. Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase. (PMID: 8661118) Zhao Z. … Caskey C.T. (Genomics 1996) 2 3 4 22 64
  2. Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene. (PMID: 11734337) Wang Q. … Waxman J. (Cancer Lett. 2002) 3 4 22 64
  3. Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. (PMID: 9018080) Cates C.A. … Crowell D.N. (Cancer Lett. 1996) 3 4 22 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PTP4A2 Gene

Sources for PTP4A2 Gene

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