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Aliases for PTP4A1 Gene

Aliases for PTP4A1 Gene

  • Protein Tyrosine Phosphatase Type IVA, Member 1 2 3 5
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 1 3 4
  • Protein-Tyrosine Phosphatase 4a1 3 4
  • EC 3.1.3.48 4 61
  • PTPCAAX1 3 4
  • PRL-1 3 4
  • PRL1 3 4
  • Protein Tyrosine Phosphatase Type IVA Protein 1 3
  • Protein Tyrosine Phosphatase Type IVA 1 3
  • PTP(CAAX1) 3
  • PTP(CAAXI) 4
  • HH72 3

External Ids for PTP4A1 Gene

Previous GeneCards Identifiers for PTP4A1 Gene

  • GC06P064264
  • GC06P064279
  • GC06P064340
  • GC06P061461

Summaries for PTP4A1 Gene

Entrez Gene Summary for PTP4A1 Gene

  • This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

GeneCards Summary for PTP4A1 Gene

PTP4A1 (Protein Tyrosine Phosphatase Type IVA, Member 1) is a Protein Coding gene. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A2.

UniProtKB/Swiss-Prot for PTP4A1 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.

Gene Wiki entry for PTP4A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTP4A1 Gene

Genomics for PTP4A1 Gene

Regulatory Elements for PTP4A1 Gene

Enhancers for PTP4A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G063456 1.3 FANTOM5 ENCODE 3.1 -62.9 -62947 4.8 HNRNPUL1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 ZHX2 LGSN PTP4A1 GC06M063463 GC06M063429 GC06M063428 GC06M063427 GC06M063421
GH06G063509 1.3 FANTOM5 ENCODE 1.6 -11.3 -11325 2.7 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SP5 MXD4 NFYC LGSN ENSG00000236345 PTP4A1 GC06P063496
GH06G063526 1.6 Ensembl ENCODE dbSUPER 0.4 +7.0 6967 3.7 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LGSN GC06M063529 PTP4A1
GH06G063518 0.9 ENCODE 0.7 -2.6 -2579 1.7 HDGF PKNOX1 ATF1 MLX CBX5 ZNF207 MXD4 JUNB PPARG TBX21 PTP4A1 GC06P063496
GH06G063522 0.8 ENCODE 0.7 +1.0 1043 0.2 SOX13 HNRNPUL1 DRAP1 TFAP4 FOXA2 SAP130 ARID4B CEBPG ZNF384 DNMT3B LGSN PTP4A1 GC06M063529
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTP4A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTP4A1 Gene

Chromosome:
6
Start:
63,521,748 bp from pter
End:
63,583,588 bp from pter
Size:
61,841 bases
Orientation:
Plus strand

Genomic View for PTP4A1 Gene

Genes around PTP4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A1 Gene

Proteins for PTP4A1 Gene

  • Protein details for PTP4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93096-TP4A1_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 1
    Protein Accession:
    Q93096
    Secondary Accessions:
    • B2R6C8
    • O00648
    • Q49A54

    Protein attributes for PTP4A1 Gene

    Size:
    173 amino acids
    Molecular mass:
    19815 Da
    Quaternary structure:
    • Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.

    Three dimensional structures from OCA and Proteopedia for PTP4A1 Gene

neXtProt entry for PTP4A1 Gene

Selected DME Specific Peptides for PTP4A1 Gene

Q93096:
  • DWPFDDGAPP
  • EELKKYGVTT
  • KFREEPGCC
  • HCVAGLGRAPVLVA
  • YLEKYRPK
  • MRFLITHNP
  • NQIVDDWL
  • QFIRQKRRGA
  • GMKYEDA

Post-translational modifications for PTP4A1 Gene

  • Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
  • Ubiquitination at Lys15 and Lys32
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PTP4A1
  • Cloud-Clone Corp. Antibodies for PTP4A1

Domains & Families for PTP4A1 Gene

Gene Families for PTP4A1 Gene

Suggested Antigen Peptide Sequences for PTP4A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q93096

UniProtKB/Swiss-Prot:

TP4A1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A1: view

Function for PTP4A1 Gene

Molecular function for PTP4A1 Gene

GENATLAS Biochemistry:
rat nuclear protein tyrosine phosphatase homolog,involved in cellular growth of the liver in differentiation of intestine and other tissues
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and pentamidine.
UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated upon tetrodotoxin treatment.

Enzyme Numbers (IUBMB) for PTP4A1 Gene

Gene Ontology (GO) - Molecular Function for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IBA,NAS 10569806
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTP4A1: view
genes like me logo Genes that share phenotypes with PTP4A1: view

Animal Model Products

CRISPR Products

miRNA for PTP4A1 Gene

miRTarBase miRNAs that target PTP4A1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTP4A1 Gene

Localization for PTP4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A1 Gene

Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTP4A1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
endoplasmic reticulum 5
endosome 5
nucleus 3
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IDA 10940933
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PTP4A1: view

Pathways & Interactions for PTP4A1 Gene

genes like me logo Genes that share pathways with PTP4A1: view

Pathways by source for PTP4A1 Gene

1 BioSystems pathway for PTP4A1 Gene
1 Qiagen pathway for PTP4A1 Gene

SIGNOR curated interactions for PTP4A1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0016311 dephosphorylation IEA --
GO:0030335 positive regulation of cell migration IBA --
genes like me logo Genes that share ontologies with PTP4A1: view

Drugs & Compounds for PTP4A1 Gene

(9) Drugs for PTP4A1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(11) Additional Compounds for PTP4A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with PTP4A1: view

Transcripts for PTP4A1 Gene

Unigene Clusters for PTP4A1 Gene

Protein tyrosine phosphatase type IVA, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:

Relevant External Links for PTP4A1 Gene

GeneLoc Exon Structure for
PTP4A1
ECgene alternative splicing isoforms for
PTP4A1

Expression for PTP4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTP4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTP4A1 Gene

This gene is overexpressed in Liver (x6.8) and Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for PTP4A1 Gene

This gene is overexpressed in Brain (22.8), Heart (12.5), Pancreas (9.7), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTP4A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PTP4A1 Gene:

PTP4A1

SOURCE GeneReport for Unigene cluster for PTP4A1 Gene:

Hs.227777

mRNA Expression by UniProt/SwissProt for PTP4A1 Gene:

Q93096-TP4A1_HUMAN
Tissue specificity: Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.

Evidence on tissue expression from TISSUES for PTP4A1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.7)
  • Muscle(4.5)
  • Heart(2.7)
  • Blood(2.5)
  • Kidney(2.5)
  • Skin(2.5)
  • Intestine(2.3)
  • Stomach(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PTP4A1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A1 Gene

Orthologs for PTP4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTP4A1 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia PTP4A1 34 35
  • 97.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A1 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptp4a1 34
  • 95.57 (n)
cow
(Bos Taurus)
Mammalia PTP4A1 34 35
  • 95.18 (n)
mouse
(Mus musculus)
Mammalia Ptp4a1 34 16 35
  • 94.99 (n)
oppossum
(Monodelphis domestica)
Mammalia PTP4A1 35
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTP4A1 34 35
  • 86.13 (n)
lizard
(Anolis carolinensis)
Reptilia PTP4A1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptp4a1 34
  • 82.66 (n)
Str.6243 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7522 34
zebrafish
(Danio rerio)
Actinopterygii ptp4a1 34 35
  • 77.46 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.678 34
fruit fly
(Drosophila melanogaster)
Insecta PRL-1 36 34 35
  • 58.63 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008708 34
  • 56.63 (n)
worm
(Caenorhabditis elegans)
Secernentea prl-1 34
  • 58.13 (n)
T19D2.2 35
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10622 35
  • 63 (a)
OneToMany
Species where no ortholog for PTP4A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTP4A1 Gene

ENSEMBL:
Gene Tree for PTP4A1 (if available)
TreeFam:
Gene Tree for PTP4A1 (if available)

Paralogs for PTP4A1 Gene

Paralogs for PTP4A1 Gene

(2) SIMAP similar genes for PTP4A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTP4A1: view

Variants for PTP4A1 Gene

Sequence variations from dbSNP and Humsavar for PTP4A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000100161 -- 63,532,841(+) AAAAA(A/C)ATAGT intron-variant
rs1000130102 -- 63,557,357(+) GGTCA(A/G)GAGTT intron-variant
rs1000154491 -- 63,582,637(+) TAGTG(A/G)GATGA utr-variant-3-prime
rs1000156309 -- 63,538,641(+) GCAAA(A/G)GAGAT intron-variant
rs1000185087 -- 63,582,266(+) AAACT(A/G)TTACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTP4A1 Gene

Variant ID Type Subtype PubMed ID
nsv965739 CNV duplication 23825009
nsv965740 CNV duplication 23825009

Variation tolerance for PTP4A1 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTP4A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTP4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A1 Gene

Disorders for PTP4A1 Gene

Relevant External Links for PTP4A1

Genetic Association Database (GAD)
PTP4A1
Human Genome Epidemiology (HuGE) Navigator
PTP4A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTP4A1

No disorders were found for PTP4A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTP4A1 Gene

Publications for PTP4A1 Gene

  1. The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer. (PMID: 9642300) Peng Y. … Taub R. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. (PMID: 15571731) Jeong D.G. … Ryu S.E. (J. Mol. Biol. 2005) 3 4 22 64
  3. Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. (PMID: 15501285) Raghavendra Prasad H.S. … Gopalakrishnakone P. (Toxicon 2004) 3 4 22 64
  4. The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. (PMID: 12235145) Wang J. … Herbst R. (J. Biol. Chem. 2002) 3 4 22 64
  5. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. (PMID: 10940933) Gjoerloff-Wingren A. … Mustelin T. (Eur. J. Immunol. 2000) 3 4 22 64

Products for PTP4A1 Gene

Sources for PTP4A1 Gene

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