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PTN Gene

protein-coding GIFtS: 63

GC07M136562

pleiotrophin
(Previous name: neurite growth-promoting factor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NEGF1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HARP ^²
HB-GAM ^³
HBBM ^³
HBGF-8 ^³
HBGF8 ^¹, ²
HBNF ^¹, ²
HBNF-1 ^³
HBNF1 ^³
NEGF1 ^², ³, ⁵
OSF-1 ^³
pleiotrophin ^²

Descriptions
Heparin-binding brain mitogen ^³
Heparin-binding growth factor 8 ^³
Heparin-binding growth-associated molecule ^², ³
Heparin-binding neurite outgrowth-promoting factor 1 ^³
Osteoblast-specific factor 1 ^³
heparin affin regulatory protein ^²
heparin binding growth factor 8 ^²
neurite growth-promoting factor 1 ^¹, ²
pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) ^²

External Ids
HGNC: 9630¹
Entrez Gene: 5764²
UniProtKB: P21246³
Ensembl: ENSG00000105894⁷

Search outside databases for aliases for PTN gene

Previous GC identifers: GC07M135254 GC07M136314 GC07M136328 GC07M136369

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PTN_HUMAN, P21246

Function: Heparin binding mitogenic protein. Has neurite extension activity

Gene Wiki entry for PTN (Pleiotrophin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PTN gene

Entrez Gene cytogenetic band: 7q33-q34 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33

PTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M136562: (about GC identifiers)

Start:	136,562,628 bp from pter
End:	136,679,086 bp from pter
Size:	116,459 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 136,256,123-136,372,579

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PTN_HUMAN, P21246 (See protein sequence)

Recommended Name: Pleiotrophin precursor

Size: 168 amino acids; 18942 Da

Subcellular location: Secreted

Secondary accessions: Q5U0B0 Q6ICQ5 Q9UCC6

REFSEQ proteins: NP_002816.1

ENSEMBL proteins:

ENSP00000376798 ENSP00000341170

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PTN
	Millipore Purified and/or Recombinant PTN Protein
	Sigma-Aldrich Proteins for PTN
	R&D Systems Recombinant & Natural Proteins for PTN (Pleiotrophin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Pleiotrophin)
	Human Recombinant Proteins from Abnova (PTN)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	10706604
GO:0005783	endoplasmic reticulum	IDA	11256614

About this table

Antibodies for PTN:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PTN
	R&D Systems Antibodies for PTN (Pleiotrophin)
	Antibodies from Abcam (Pleiotrophin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PTN)
	Novus Biologicals Antibodies for PTN

Assays for PTN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P21246

ProtoNet protein and cluster: P21246

1 Blocks protein family: IPB000762 PTN/MK heparin-binding protein

UniProtKB/Swiss-Prot: PTN_HUMAN, P21246

Similarity: Belongs to the pleiotrophin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002825

Applied Biosystems Silencer® siRNAs for PTN

Sigma-Aldrich siRNA and siRNA Panels for PTN

Sigma-Aldrich shRNA Panels and shRNA for PTN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PTN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002825
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002825
untagged cDNA clones in CMV expression vector (see all 2): NM_002825

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002825

UniProtKB/Swiss-Prot: PTN_HUMAN, P21246

Function: Heparin binding mitogenic protein. Has neurite extension activity

Induction: By heparin and retinoic acid

Genatlas biochemistry entry for PTN:

pleiotrophin,18.9kDa,widely expressed and developmentally regulated,heparin-binding cytokine

family,inducing neurite extension outgrow in osteoblasts and brain cells and in diverse other

activities

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptn):

behavior/neurological	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	nervous system	reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004864	phosphoprotein phosphatase inhibitor activity	TAS	10706604
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PTN

5/99 Interacting proteins for PTN (ENSP00000341170³ P21246²) via UniProtKB, MINT, and/or STRING (see all 99 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHD3	Q12873²	MINT-63554 MINT-3980182
APOBEC3G	Q9HC16²	MINT-65551
ARIH2	O95376²	MINT-63291
ATP5C1	P36542²	MINT-63702
BARD1	Q99728²	MINT-3978824

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	TAS	10706604
GO:0007399	nervous system development	TAS	2270483
GO:0007612	learning	IEA	--
GO:0008284	positive regulation of cell proliferation	TAS	2270483
GO:0030282	bone mineralization	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PTN
10/12 Novoseek chemical compound relationships for PTN gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
chondroitin sulfate	59.67	27	16373346 (7), 12684467 (2), 16175577 (2), 17680989 (1) (see all 8)
tyrosine	59.06	94	10706604 (5), 15925565 (4), 9235965 (3), 18474614 (3) (see all 37)
neurocan	52.76	4	9507007 (3), 11766883 (1)
heparan sulfate	42.32	9	10075664 (2), 15203110 (1), 16156786 (1), 16155004 (1) (see all 5)
wortmannin	24.36	3	9235965 (1), 11241349 (1), 17960557 (1)
matrigel	16.94	3	11241349 (1), 15001987 (1), 15797857 (1)
glycosaminoglycan	15.68	2	15203110 (1)
thymidine	11.21	4	11936877 (1), 9389569 (1), 9041202 (1), 12421346 (1)
oligonucleotide	9.14	1	1407714 (1)
nitric oxide	0.00	20	19058221 (4), 11241349 (2), 17960557 (1), 17614755 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002825

Sigma-Aldrich siRNA and siRNA Panels for PTN

Sigma-Aldrich shRNA Panels and shRNA for PTN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002825

REFSEQ mRNAs for PTN gene:

NM_002825.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002825

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002825
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002825
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002825

Additional cDNA sequence:

AK290488.1 AK297725.1 AK313424.1 BC005916.1 BT019692.1 CR450338.1 CR596476.1 CR609152.1

CR614046.1 CR619084.1 CR620419.1 CR624136.1 D90226.1 M57399.1 X52946.1

9 DOTS entries:

DT.317555 DT.99936772 DT.92444840 DT.100796060 DT.100796063 DT.100796066 DT.92444835 DT.92444824

DT.92444844

24/268 AceView cDNA sequences (see all 268 ):

AI797499 AI419278 CK002913 H88349 BM968820 AW590267 CR609152 CR596476

AA318830 BQ302232 AI380075 CD672995 AA846221 BX463559 BM929772 AU120808

H87964 D90226 BC005916 BX444323 X52946 H88665 AW157101 BI759999

highest scoring ESTs for PTN:

M57399 AA090718 AA090747 AA318827 AA318830 AA319095 AI338085 AI611319 AI797499 AI879135

Unigene Cluster for PTN:

Pleiotrophin

Hs.371249 [show with all ESTs]

Unigene Representative Sequence: CR624136

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000393083 ENST00000348225

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PTN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PTN

¹ / ² / ³

8 probe-sets matching PTN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
234_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.89	M57399	1.00	1.00	1.00	1
34820_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.11	M57399	1.00	1.00	1.00	1
211737_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005916	0.80	1.00	0.91	1
209466_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M57399	1.00	1.00	1.00	1
209465_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL565812	0.60	1.00	0.82	1
211737_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209466_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209465_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PTN for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCTAGTTCA

SOURCE GeneReport for Unigene cluster: Hs.371249
Expression variation in blood from EXPOLDB for PTN
UniProtKB/Swiss-Prot: PTN_HUMAN, P21246
Tissue specificity: Osteoblast and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PTN gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PTN¹	--	pleiotrophin	93.85(n) 98.21(a)	475509 XM_532732.2 XP_532732.2
cow (Bos taurus)	PTN¹	--	pleiotrophin	92.66(n) 97.02(a)	280904 NM_173955.1 NP_776380.1
rat (Rattus norvegicus)	Ptn¹	--	pleiotrophin	90.08(n) 97.62(a)	24924 NM_017066.2 NP_058762.1
mouse (Mus musculus)	Ptn^{1, 5}	6 (13.50 cM)⁵	pleiotrophin^{1, 5}	89.09(n)¹ 97.62(a)¹	19242¹ NM_008973.2¹ NP_032999.1¹ AK011346⁵ AK011699⁵ (see all 26)
chicken (Gallus gallus)	PTN¹	--	pleiotrophin	85.07(n) 91.41(a)	418125 XM_416358.2 XP_416358.1

About this table Species with no ortholog for PTN

ENSEMBL Gene Tree for PTN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/668 NCBI SNPs in PTN are shown (see all 668 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 267)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs321198^1,2	A,C,F,H	136680378(+)	`ACTTCC/TGTGTG`	1	--	ng3¹		9	MN EU EA WA NA	966
--	rs224161^1,2	A,C,F,H	136680826(+)	`tggagA/Gtagtc`	1	--	ng3¹		4	EU EA WA	418
	rs6970141^1,2	A,C,F,H	136562354(+)	`ACTGTC/TGCTAG`	1	--	ng5¹		16	EA NA EU WA	1472
	rs161335^1,2	A,C,F,H	136680885(+)	`gaagcC/Tgggga`	1	--	ng3¹		8	EU EA WA	830
	rs12668115^1,2	C,F,H	136562578(+)	`ATAAAT/CGACTA`	1	--	ng5¹		11	NA EU EA WA	974
	rs17168987^1,2	C,F,H	136562506(+)	`CCTTTG/ATGCCC`	1	--	ng5¹		15	NA EU EA WA	1400
	rs1647723^1,2	H	136562223(-)	`TCTGTT/GGGCCT`	1	--	ng5¹		5	MN EU EA WA	594
	rs4636151^1,2	H	136680935(+)	`taccaG/Aaaagc`	1	--	ng3¹		4	EU EA WA	416
	rs322347^1,2	A,C,F,H,O	136643724(-)	`CACCAC/TTGTAG`	1	--	int¹		11	EU EA WA NA	974
	rs322246^1,2	A,C,F,H,O	136610707(+)	`ATAATA/GTCCCA`	1	--	int¹		16	EU EA WA NA	1416

About this table

HapMap Linkage Disequilibrium images for PTN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 162095

10/36 Novoseek disease relationships for PTN gene (see all 36 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	63.80	39	15986444 (7), 14692702 (3), 15908427 (3), 15684595 (3) (see all 14)
benign meningioma	44.77	2	1407714 (1), 15379633 (1)
tumors	44.00	179	16554021 (5), 8063762 (4), 18156802 (4), 14504053 (3) (see all 55)
lymphoma	38.92	19	12107166 (2), 11809760 (2), 15886198 (1), 15908427 (1) (see all 12)
glioma	38.06	20	12421346 (7), 14692702 (1), 16923162 (1), 15684595 (1) (see all 9)
choriocarcinoma	33.73	5	10962555 (2), 18221061 (1), 8962128 (1), 11016659 (1)
mammary tumor	30.83	6	16507572 (1), 17578909 (1), 18156802 (1), 15379633 (1) (see all 5)
carcinoma embryonal	28.39	2	1373617 (1)
cancer	25.83	39	18221061 (3), 9776412 (2), 1464602 (2), 15542254 (2) (see all 17)
breast cancer	24.27	58	17578909 (6), 7533562 (4), 9201975 (3), 17490616 (2) (see all 11)

About this table

Human Genome Epidemiology Navigator: PTN (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

AACR: Serum Pleiotrophin Proposed as Marker for Early Stage Testicular Cancer

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/226 PubMed articles for PTN gene (see all 226 ):

Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene. (PubMed id 1457401)^{1, 2, 3, 4} Milner P.G.... Kumar B.V. (1992)
Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins. (PubMed id 1768439)^{1, 2, 3, 4} Kretschmer P.J....Kovesdi I. (1991)
Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor- 1. (PubMed id 9299545)^{1, 3, 4} Masuda H.... Hashimoto-Gotoh T. (1997)
A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine. (PubMed id 1733956)^{1, 3, 4} Wellsein A.... Lippman M.E. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant. (PubMed id 8484754)^{3, 4} Kretschmer P.J....Kovesdi I. (1993)
Comparison of the disulfide bond arrangements of human recombinant and bovine brain heparin binding neurite-promoting factors. (PubMed id 8484780)^{3, 4} Hulmes J.D.... Bohlen P. (1993)
Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues. (PubMed id 1701634)^{3, 4} Tezuka K.I....Hashimoto-Gotoh T. (1990)
Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. (PubMed id 2270483)^{3, 4} Li Y.-S.... Deuel T.F. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5764	HGNC: 9630	AceView: PTN	Ensembl:ENSG00000105894	euGenes: HUgn5764
ECgene: PTN	H-InvDB: PTN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PTN	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Pleiotrophin

Licensable Technologies for PTN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PTN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PTN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PTN		Antibodies for PTN
	Explore super-pooled esiRNAs		Proteins for PTN
	Lentivirus-delivered shRNAs for PTN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PTN)
	Antibodies (PTN)
	Chimera RNAi (PTN)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Pleiotrophin)
	Antibodies (Pleiotrophin)

Search OriGene for PTN

Search Tocris compounds for PTN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PTN

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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PTN Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for PTN

Summaries
for PTN

Genomic Location
for PTN

Proteins
for PTN

Protein Domains/
Families
for PTN

Gene Function
for PTN

Pathways & Interactions
for PTN

Drugs & Compounds
for PTN

Transcripts
for PTN

Expression
for PTN

Orthologs
for PTN

Paralogs
for PTN

SNPs/Variants
for PTN

Disorders & Mutations
for PTN

Medical News
for PTN

Publications
for PTN

Search for PTN

Genome Databases showing PTN

Other Databases showing PTN

Specialized Databases showing PTN

Licensable Technologies
for PTN

Services
for PTN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PTN (Gene Symbol)
HARP
HB-GAM
HBBM
HBGF-8
HBGF8
HBNF
HBNF-1
HBNF1
NEGF1
OSF-1
pleiotrophin
Heparin-binding brain mitogen
Heparin-binding growth factor 8
Heparin-binding growth-associated molecule
Heparin-binding neurite outgrowth-promoting factor 1
Osteoblast-specific factor 1
heparin affin regulatory protein
heparin binding growth factor 8
neurite growth-promoting factor 1
pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

PTN Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor PTN

Summariesfor PTN

Genomic Locationfor PTN

Proteinsfor PTN

Protein Domains/Familiesfor PTN

Gene Functionfor PTN

Pathways & Interactionsfor PTN

Drugs & Compoundsfor PTN

Transcriptsfor PTN

Expression for PTN

Orthologsfor PTN

Paralogsfor PTN

SNPs/Variantsfor PTN

Disorders & Mutationsfor PTN

Medical Newsfor PTN

Publicationsfor PTN

Search for PTN

Genome Databases showing PTN

Other Databases showing PTN

Specialized Databases showing PTN

Licensable Technologiesfor PTN

Servicesfor PTN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PTN

Summaries
for PTN

Genomic Location
for PTN

Proteins
for PTN

Protein Domains/
Families
for PTN

Gene Function
for PTN

Pathways & Interactions
for PTN

Drugs & Compounds
for PTN

Transcripts
for PTN

Expression
for PTN

Orthologs
for PTN

Paralogs
for PTN

SNPs/Variants
for PTN

Disorders & Mutations
for PTN

Medical News
for PTN

Publications
for PTN

Licensable Technologies
for PTN

Services
for PTN