PTN Gene

Aliases
for PTN gene

Previous GC identifers: GC07M135254 GC07M136314 GC07M136328 GC07M136369 GC07M136562 GC07M131217

Summaries
for PTN gene

Genomic Views
for PTN gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTN promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTN

PTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M136912:  view genomic region     (about GC identifiers)

Proteins
for PTN gene

Explore the universe of human proteins at neXtProt for PTN: NX_P21246

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant PTN Protein
	R&D Systems Recombinant & Natural Proteins for PTN (Pleiotrophin/PTN)
	Enzo Life Sciences proteins for PTN
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PTN OriGene Custom Protein Services for PTN
	GenScript Custom Purified and Recombinant Proteins Services for PTN
	Novus Biologicals PTN Proteins Novus Biologicals PTN Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PTN
	Uscn Proteins for PTN

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PTN (Pleiotrophin/PTN)
	OriGene Antibodies: PTN OriGene Custom Antibody Services for PTN
	GenScript Custom Superior Antibodies Services for PTN
	Novus Biologicals PTN Antibodies
	Abcam antibodies for PTN
	Uscn Antibodies for PTN
	ThermoFisher Antibodies for PTN

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PTN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTN

Protein Domains /
Families
for PTN gene

ProtoNet protein and cluster: P21246

Function
for PTN gene

miRNA Products:		OriGene 3'-UTR Clone: PTN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PTN:
		hsa-miR-96* hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: PTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTN (see all 7) OriGene shRNA RFP: PTN OriGene siRNA: PTN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTN

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PTN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTN (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTN (NM_002825)
		Sino Biological Human cDNA Clone for PTN
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTN
		Search LifeMap BioReagents cell lines for PTN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Ptn)

Pathways & Interactions
for PTN gene

	Super-pathway	contained gene-specific pathways
1	Apoptotic Pathways in Synovial Fibroblasts	8/14 pathways (see all 14) Apoptotic Pathways in Synovial Fibroblasts 1.00 ERK5 Signaling 0.61 p53 Mediated Apoptosis 0.84 eIF2 Pathway 0.60 Mitochondrial Apoptosis 0.73 Rac1 Pathway 0.58 Telomerase Components in Cell Signaling 0.72 Nuclear Receptor Activation by Vitamin-A 0.57
2	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58
3	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
4	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JAK-STAT Pathway 0.57 MAPK Family Pathway 0.60 JNK Pathway 0.50
5	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48

1 EMD Millipore Pathway for PTN

Neurophysiological process Receptor-mediated axon growth repulsion

5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTN

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 GeneGo (Thomson Reuters) Pathway for PTN

Neurophysiological process Receptor-mediated axon growth repulsion

1 BioSystems Pathway for PTN

Syndecan-3-mediated signaling events

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for PTN gene

Transcripts
for PTN gene

Expression
for PTN gene

PTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTAGTTCA

9 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyMetanephric MesenchymeMetanephric Mesenchyme Cells			Kidney
	LiverHepatic MesenchymeMesothelial Cells			Liver
	BrainBlood Brain BarrierAdult Endothelial Cells			Blood Brain Barrier, Endothelium
	Gut TubeForegutForegut Endoderm Cells			Endoderm
	LungTracheaBasal Cells			Lung
	OvaryAntral FollicleCumulus Cells			Ovary
	KidneyMetanephros			Kidney
	LungLung Bud			Lung
	Reproductive SystemMesonephros			Reproductive System
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
	Posterior foregut-like cells (A scalable, suspensi...)
	Primordial germ cell-like cells (Reconstitution of mo...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTN

Orthologs
for PTN gene

Paralogs
for PTN gene

Paralogs for PTN gene

MDK²  

1 SIMAP similar gene for PTN using alignment to 2 protein entries:     PTN_HUMAN (see all proteins):

MDK

PTN for paralogs           About GeneDecksing

Genomic Variants
for PTN gene

10/2076 NCBI SNPs in PTN are shown (see all 2076)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1460343191,2		--	136911678(+)	CTTAGA/GGGCCA	1	--	int1		0	--	--	--	--
rs16477231,2	C,H	--	136911683(-)	TCTGTT/GGGCCT	1	--	int1		5		MN NS EA	594
rs1150007121,2	F,	--	136911792(+)	CATTAC/TAGTGA	1	--	int1		1		WA	118
rs69701411,2	C,F,A,H,	--	136911814(+)	ACTGTC/TGCTAG	1	--	int1		31		EA NA NS WA CSA	3402
rs1386286151,2		--	136911832(+)	ATATCC/TACTAT	1	--	int1		0	--	--	--	--
rs1914649431,2		--	136911867(+)	ACCCTA/CGACTA	1	--	int1		0	--	--	--	--
rs171689871,2	C,F,H,	--	136911966(+)	CCTTTG/ATGCCC	1	--	int1		30		NA NS EA WA CSA	3122
rs126681151,2	C,F,H,	--	136912038(+)	ATAAAT/CGACTA	1	--	int1		28		NA NS EA WA CSA	2914
rs715413431,2	C,F,	--	136912229(+)	AAAAGT/ACAACA	1	--	ut31		2		NA	4
rs1459080291,2	C,	--	136912464(+)	AATGT-/AAAAAA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTN (136912088 - 137028611 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for PTN
     3 CNVs: 94891 7605 64958
     2 Indels: 47245 82197

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTN

DNA2.0 Custom Variant and Variant Library Synthesis for PTN

Disorders / Diseases
for PTN gene

20/50 diseases for PTN

10/37 Novoseek disease relationships for PTN gene (see all 37)    About this table

Publications
for PTN gene

PubMed articles for PTN gene, integrated from 9 sources (see all 264): (articles sorted by number of sources associating them with PTN)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene. (PubMed id 1457401)^{1, 2, 3, 9} Milner P.G.... Kumar B.V. (1992)
2. Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins. (PubMed id 1768439)^{1, 2, 3, 9} Kretschmer P.J.... Kovesdi I. (1991)
3. Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin. (PubMed id 11278720)^{1, 2, 9} Stoica G.E....Wellstein A. (2001)
4. Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor- 1. (PubMed id 9299545)^{1, 2, 9} Masuda H.... Hashimoto-Gotoh T. (1997)
5. A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine. (PubMed id 1733956)^{1, 2, 9} Wellsein A.... Lippman M.E. (1992)
6. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. (PubMed id 2270483)^{1, 2, 9} Li Y.-S.... Deuel T.F. (1990)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
9. Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant. (PubMed id 8484754)^{1, 2} Kretschmer P.J....Kovesdi I. (1993)
10. Comparison of the disulfide bond arrangements of human recombinant and bovine brain heparin binding neurite-promoting factors. (PubMed id 8484780)^{1, 2} Hulmes J.D.... Bohlen P. (1993)

External Searches for PTN gene

Genome Databases showing PTN gene

Other Databases showing PTN gene

Specialized Databases showing PTN gene

Products
for PTN gene