Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PTN Gene

protein-coding   GIFtS: 64
GCID: GC07M136912

Pleiotrophin

(Previous name: neurite growth-promoting factor 1)
(Previous symbol: NEGF1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
pleiotrophin1 2     HBBM2 3
NEGF11 2 3 5     HBGF-82 3
Neurite Growth-Promoting Factor 11 2     HBNF-12 3
Heparin Binding Growth Factor 81 2     OSF-12 3
Heparin-Binding Brain Mitogen2 3     HARP2
Heparin-Binding Growth Factor 82 3     HBGF82
Heparin-Binding Growth-Associated Molecule2 3     HBNF2
Heparin-Binding Neurite Outgrowth-Promoting Factor 12 3     Heparin Affin Regulatory Protein2
Osteoblast-Specific Factor 12 3     Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-Promoting
Factor 1)2
HB-GAM2 3     HBNF13

External Ids:    HGNC: 96301   Entrez Gene: 57642   Ensembl: ENSG000001058947   OMIM: 1620955   UniProtKB: P212463   

Export aliases for PTN gene to outside databases

Previous GC identifers: GC07M135254 GC07M136314 GC07M136328 GC07M136369 GC07M136562 GC07M131217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PTN Gene:
PTN (pleiotrophin) is a protein-coding gene. Diseases associated with PTN include benign meningioma, and tetraploidy. GO annotations related to this gene include growth factor activity and protein phosphatase inhibitor activity. An important paralog of this gene is MDK.

UniProtKB/Swiss-Prot: PTN_HUMAN, P21246
Function: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts,
epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation,
an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation

Gene Wiki entry for PTN (Pleiotrophin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTN gene promoter:
         NF-1   NF-1/L   STAT1   IRF-1   IRF-2   POU2F1   Nkx6-1   HFH-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTN promoter sequence
   Search Chromatin IP Primers for PTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

PTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTN gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M136912:  view genomic region     (about GC identifiers)

Start:
136,912,088 bp from pter      End:
137,028,611 bp from pter
Size:
116,524 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 136,256,123-136,372,579     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PTN_HUMAN, P21246 (See protein sequence)
Recommended Name: Pleiotrophin precursor  
Size: 168 amino acids; 18942 Da
Subunit: Interacts with ALK and NEK6
Secondary accessions: Q5U0B0 Q6ICQ5 Q9UCC6

Explore the universe of human proteins at neXtProt for PTN: NX_P21246

Explore proteomics data for PTN at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK61
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002816.1  
    ENSEMBL proteins: 
     ENSP00000341170   ENSP00000376798  

    PTN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PTN (Pleiotrophin/PTN)
    Enzo Life Sciences proteins for PTN
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PTN
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PTN
    GenScript Custom Purified and Recombinant Proteins Services for PTN
    Novus Biologicals PTN Proteins
    Novus Biologicals PTN Lysate
    Sino Biological Recombinant Protein for PTN
    Sino Biological Cell Lysate for PTN
    ProSpec Recombinant Protein for PTN
    Cloud-Clone Corp. Proteins for PTN

    PTN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PTN (Pleiotrophin/PTN)
    OriGene Antibodies for PTN
    OriGene Custom Antibody Services for PTN
    Novus Biologicals PTN Antibodies
    Abcam antibodies for PTN
    Cloud-Clone Corp. Antibodies for PTN
    ThermoFisher Antibodies for PTN
    LSBio Antibodies in human, mouse, rat for PTN

    PTN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTN
    Cloud-Clone Corp. CLIAs for PTN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR020089 PTN/MK_N_dom
     IPR020091 PTN/MK_diS
     IPR000762 Midkine_heparin-bd_GF
     IPR020092 PTN_MK_heparin-bd_GF_CS
     IPR020090 PTN/MK_C_dom

    Graphical View of Domain Structure for InterPro Entry P21246

    ProtoNet protein and cluster: P21246

    1 Blocks protein domain: IPB000762 PTN/MK heparin-binding protein

    UniProtKB/Swiss-Prot: PTN_HUMAN, P21246
    Similarity: Belongs to the pleiotrophin family


    PTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTN_HUMAN, P21246
    Function: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts,
    epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation,
    an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation
    Induction: By heparin and retinoic acid

         Genatlas biochemistry entry for PTN:
    pleiotrophin,18.9kDa,widely expressed and developmentally regulated,heparin-binding cytokine family,inducing
    neurite extension outgrow in osteoblasts and brain cells and in diverse other activities

         Summary: 
    During embryonic development, PTN as signaling molecule is secreted from the following cells:
                
    Kidney: Metanephric Mesenchyme Cells (Metanephric Mesenchyme)
    PTN as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Brain: Dopaminergic neuron-like cells, Dopaminergic neuron-like cells
    Neurons: Dopaminergic neuron-like cells, Dopaminergic neuron-like cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity TAS10706604
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
         
    PTN for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptn):
     behavior/neurological  cellular  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  nervous system  reproductive system 

    PTN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTN: Ptntm1Rau Ptntm1Tmu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTN

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PTN using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PTN:
    hsa-miR-96* hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidPTN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTN
    Predesigned siRNA for gene silencing in human, mouse, rat PTN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTN

    Clone
    Products:
         
    OriGene clones in human, mouse for PTN (see all 9)
    OriGene ORF clones in mouse, rat for PTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTN (NM_002825)
    Sino Biological Human cDNA Clone for PTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTN
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PTN_HUMAN, P21246: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    cytosol3
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS10706604
    GO:0005783endoplasmic reticulum IDA--

    PTN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PTN About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTN (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for PTN
        Neurophysiological process Receptor-mediated axon growth repulsion

    1 BioSystems Pathway for PTN
        Syndecan-3-mediated signaling events



        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTN: 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTN (P212462, 3 ENSP000003411704) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-65816 I2D: score=5 
    DNAJB11Q9UBS42, 3MINT-65690 MINT-8254276 I2D: score=5 
    GLYATQ6IB772, 3, ENSP000003402004MINT-63081 I2D: score=5 STRING: ENSP00000340200
    LUC7L2Q9Y3832, 3MINT-65816 I2D: score=5 
    GADD45GO952572, 3, ENSP000002525064MINT-3979103 I2D: score=4 STRING: ENSP00000252506
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification ----
    GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway TAS10706604
    GO:0007399nervous system development TAS2270483
    GO:0007612learning IEA--
    GO:0008284positive regulation of cell proliferation TAS2270483

    PTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTN

    1 HMDB Compound for PTN    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    Selected Novoseek inferred chemical compound relationships for PTN gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 63.3 144 17607711 (5), 10075664 (5), 10413105 (4), 11936877 (3) (see all 43)
    tyrosine 60.3 100 10706604 (5), 15925565 (4), 9235965 (3), 18474614 (3) (see all 41)
    chondroitin sulfate 58.2 27 16373346 (7), 12684467 (2), 16175577 (2), 17680989 (1) (see all 8)
    neurocan 51 4 9507007 (3), 11766883 (1)
    dermatan sulfate 49.6 12 10075664 (3), 10600521 (1), 15203110 (1), 17145750 (1) (see all 6)
    heparan sulfate 44.1 9 10075664 (2), 15203110 (1), 16156786 (1), 16155004 (1) (see all 5)
    vegf 37.8 23 11241349 (2), 17960557 (2), 12762884 (2), 15001987 (2) (see all 14)
    agar 29.5 4 9389569 (1), 8241100 (1), 11016659 (1), 1464602 (1)
    retinoic acid 23.7 9 14708942 (3), 1373617 (2), 1768439 (1), 8408430 (1)
    wortmannin 22.3 3 9235965 (1), 11241349 (1), 17960557 (1)



    PTN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PTN gene: 
    NM_002825.5  

    Unigene Cluster for PTN:

    Pleiotrophin
    Hs.371249  [show with all ESTs]
    Unigene Representative Sequence: NM_002825
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348225(uc003vtq.2) ENST00000393083

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTN using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PTN:
    hsa-miR-96* hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidPTN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTN
    Predesigned siRNA for gene silencing in human, mouse, rat PTN
    Clone
    Products:
         
    OriGene clones in human, mouse for PTN (see all 9)
    OriGene ORF clones in mouse, rat for PTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTN (NM_002825)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PTN
    OriGene qSTAR qPCR primer pairs in human, mouse for PTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTN
      QuantiTect SYBR Green Assays in human, mouse, rat PTN
      QuantiFast Probe-based Assays in human, mouse, rat PTN

    Additional mRNA sequence: 

    AK290488.1 AK297725.1 AK313424.1 BC005916.1 BT019692.1 CR450338.1 D90226.1 M57399.1 
    X52946.1 

    19 DOTS entries:

    DT.317555  DT.99936772  DT.92444840  DT.100796060  DT.100796063  DT.100796066  DT.121385298  DT.92444835 
    DT.100687269  DT.456355  DT.91779772  DT.92444824  DT.92444844  DT.100687279  DT.121385358  DT.423630 
    DT.91779825  DT.91779856  DT.92340111 

    Selected AceView cDNA sequences (see all 268):

    BM929772 CR596476 CD672995 BF971299 CD106944 H88349 H87964 AU120808 
    H88608 AA318830 AW590267 BC005916 BM924624 BM968820 AI419278 CR620419 
    H88665 BQ302232 CR609152 AI380075 BM684821 AW157101 BI759999 H88609 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTAGTTCA
    PTN Expression
    About this image


    PTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
             Floor plate-like cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    PTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371249

    UniProtKB/Swiss-Prot: PTN_HUMAN, P21246
    Tissue specificity: Osteoblast and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTN: 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PTN
    OriGene qSTAR qPCR primer pairs in human, mouse for PTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTN
    QuantiTect SYBR Green Assays in human, mouse, rat PTN
    QuantiFast Probe-based Assays in human, mouse, rat PTN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PTN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptn1 , 5 pleiotrophin1, 5 89.09(n)1
    97.62(a)1
      6 (15.48 cM)5
    192421  NM_008973.21  NP_032999.11 
     367156635 
    chicken
    (Gallus gallus)
    Aves PTN1 pleiotrophin 85.75(n)
    93.55(a)
      418125  NM_001276362.1  NP_001263291.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTN6
    pleiotrophin
    75(a)
    1 ↔ 1
    GL343419.1(182035-288042)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9012 Xenopus laevis mRNA for pleiotrophic factor-beta2, more 80.67(n)    D42060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF149801.12   -- 72.97(n)   65231  AF149801.1 


    ENSEMBL Gene Tree for PTN (if available)
    TreeFam Gene Tree for PTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PTN gene
    MDK2  
    1 SIMAP similar gene for PTN using alignment to 2 protein entries:     PTN_HUMAN (see all proteins):
    MDK

    PTN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PTN (see all 2410)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460343191,2
    --136911678(+) CTTAGA/GGGCCA 1 -- int10--------
    rs16477231,2
    C,H--136911683(-) TCTGTT/GGGCCT 1 -- int15Minor allele frequency- G:0.00MN NS EA 594
    rs1150007121,2
    F--136911792(+) CATTAC/TAGTGA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs69701411,2
    C,F,A,H--136911814(+) ACTGTC/TGCTAG 1 -- int131Minor allele frequency- N:0.00EA NA NS WA CSA 3402
    rs1386286151,2
    C--136911832(+) ATATCC/TACTAT 1 -- int10--------
    rs1914649431,2
    --136911867(+) ACCCTA/CGACTA 1 -- int10--------
    rs587555091,2
    C--136911936(+) AATAC-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs171689871,2
    C,F,H--136911966(+) CCTTTG/ATGCCC 1 -- int130Minor allele frequency- A:0.15NA NS EA WA CSA 3122
    rs126681151,2
    C,F,H--136912038(+) ATAAAT/CGACTA 1 -- int128Minor allele frequency- C:0.14NA NS EA WA CSA 2914
    rs357548801,2
    C--136912215(+) AAAAA-/A/AA  
            
    AAAGT
    2 -- ut311NA 2

    HapMap Linkage Disequilibrium report for PTN (136912088 - 137028611 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTN (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735205CNV Deletion23290073
    esv2668149CNV Deletion23128226
    esv2669214CNV Deletion23128226
    esv2166281CNV Deletion18987734
    nsv889242CNV Loss21882294
    nsv524262CNV Loss19592680
    dgv7498n71CNV Loss21882294
    nsv889235CNV Loss21882294
    esv24450CNV Loss19812545
    dgv7497n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTN
    DNA2.0 Custom Variant and Variant Library Synthesis for PTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 162095    OMIM disorders: --

    Selected diseases for PTN (see all 49):    
    About MalaCards
    benign meningioma    tetraploidy    trigeminal neuralgia    peyronie's disease
    peyronies disease    meningioma    fibrous histiocytoma    histiocytoma
    wilms tumor    cholesteatoma    hypertrophic scars    malignant glioma
    testicular cancer    choriocarcinoma    osteoarthritis    osteosarcoma
    astrocytoma    lung cancer    peritonitis    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for PTN:
    Cancer

    PTN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PTN gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 62.7 40 15986444 (7), 14692702 (3), 15908427 (3), 19177199 (3) (see all 14)
    tumors 44.5 187 16554021 (5), 8063762 (4), 18156802 (4), 14504053 (3) (see all 59)
    benign meningioma 42.6 2 1407714 (1), 15379633 (1)
    lymphoma 42.2 23 12107166 (2), 11809760 (2), 15886198 (1), 15908427 (1) (see all 15)
    glioma 35.7 20 12421346 (7), 14692702 (1), 16923162 (1), 15684595 (1) (see all 9)
    choriocarcinoma 31.8 5 10962555 (2), 18221061 (1), 8962128 (1), 11016659 (1)
    mammary tumor 28.8 6 16507572 (1), 17578909 (1), 18156802 (1), 15379633 (1) (see all 5)
    neovascularization 27.1 8 18391787 (3), 16614316 (1), 17515817 (1)
    carcinoma embryonal 26.6 2 1373617 (1)
    metastasis 23.5 22 8962127 (3), 15606670 (2), 11241349 (1), 9389569 (1) (see all 12)

    Genetic Association Database (GAD): PTN
    Human Genome Epidemiology (HuGE) Navigator: PTN (4 documents)

    Export disorders for PTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PTN gene, integrated from 10 sources (see all 272):
    (articles sorted by number of sources associating them with PTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene. (PubMed id 1457401)1, 2, 3, 9 Milner P.G.... Kumar B.V. (Biochemistry 1992)
    2. Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins. (PubMed id 1768439)1, 2, 3, 9 Kretschmer P.J.... Kovesdi I. (Growth Factors 1991)
    3. Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin. (PubMed id 11278720)1, 2, 9 Stoica G.E.... Wellstein A. (J. Biol. Chem. 2001)
    4. Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor- 1. (PubMed id 9299545)1, 2, 9 Masuda H.... Hashimoto-Gotoh T. (Biochem. Biophys. Res. Commun. 1997)
    5. A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine. (PubMed id 1733956)1, 2, 9 Wellsein A.... Lippman M.E. (J. Biol. Chem. 1992)
    6. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. (PubMed id 2270483)1, 2, 9 Li Y.-S.... Deuel T.F. (Science 1990)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)1, 2 Vaz Meirelles G.... Kobarg J. (J. Proteome Res. 2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5764 HGNC: 9630 AceView: PTN Ensembl:ENSG00000105894 euGenes: HUgn5764
    ECgene: PTN H-InvDB: PTN

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PTN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTN Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Pleiotrophin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PTN gene:
    Search GeneIP for patents involving PTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for PTN (Pleiotrophin/PTN)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for PTN (Pleiotrophin/PTN)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PTN   OriGene RNAi products in human, mouse, rat for PTN  
     OriGene qPCR primer pairs and template standards for PTN   OriGene Protein Over-expression Lysate for PTN  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PTN  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PTN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTN   OriGene Custom Protein Services for PTN  

     
     
     Block miRNA regulation of human, mouse, rat PTN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PTN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTN Predesigned siRNA for gene silencing in human, mouse, rat PTN
     QuantiFast Probe-based Assays in human, mouse, rat PTN QuantiTect SYBR Green Assays in human, mouse, rat PTN
     PCR Arrays including human, mouse, rat PTN Search Chromatin IP Primers for PTN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTN  GeneGlobe Interaction Network for PTN
     Regulatory tfbs in PTN promoter
     GenScript Custom Purified and Recombinant Proteins Services for PTN GenScript cDNA clones with any tag delivered in your preferred vector for PTN
     GenScript Custom Assay Services for PTN GenScript Custom overexpressing Cell Line Services for PTN
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PTN
     Proteins for PTN
     Cell Lysates for PTN
     cDNA Clones for PTN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for PTN
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PTN antibodies
     PTN proteins
     PTN lysates
     Antibodies for PTN
     See all of Abcam's Antibodies, Kits and Proteins for PTN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PTN
     Proteins for PTN
     Antibodies for PTN
     ELISAs for PTN
     CLIAs for PTN



     Browse ESI BIO Cell Lines and PureStem Progenitors for PTN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTN
     SwitchGear 3'UTR luciferase reporter plasmids for PTN
     SwitchGear Promoter luciferase reporter plasmids for PTN
     ThermoFisher Antibodies for PTN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTN
     LSBio Antibodies in human, mouse, rat for PTN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PTN gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4