Aliases for PTN Gene
External Ids for PTN Gene
Previous HGNC Symbols for PTN Gene
Previous GeneCards Identifiers for PTN Gene
GeneCards Summary for PTN Gene
PTN (Pleiotrophin) is a Protein Coding gene. Diseases associated with PTN include Bronchus Cancer and Toxic Diffuse Goiter. Among its related pathways are Development Slit-Robo signaling and p70S6K Signaling. GO annotations related to this gene include growth factor activity and protein phosphatase inhibitor activity. An important paralog of this gene is MDK.
UniProtKB/Swiss-Prot for PTN Gene
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).