Aliases for PTN Gene
External Ids for PTN Gene
Previous HGNC Symbols for PTN Gene
Previous GeneCards Identifiers for PTN Gene
The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
GeneCards Summary for PTN Gene
PTN (Pleiotrophin) is a Protein Coding gene. Diseases associated with PTN include Toxic Diffuse Goiter and Breast Cancer. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include growth factor activity and protein phosphatase inhibitor activity. An important paralog of this gene is MDK.
UniProtKB/Swiss-Prot for PTN Gene
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).