Aliases for PTN Gene
External Ids for PTN Gene
Previous HGNC Symbols for PTN Gene
Previous GeneCards Identifiers for PTN Gene
GeneCards Summary for PTN Gene
PTN (Pleiotrophin) is a Protein Coding gene. Diseases associated with PTN include bronchus cancer and toxic diffuse goiter. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. GO annotations related to this gene include growth factor activity and protein phosphatase inhibitor activity. An important paralog of this gene is MDK.
UniProtKB/Swiss-Prot for PTN Gene
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.