PTMS Gene
protein-coding GIFtS: 50
GCID: GC12P006875
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parathymosin
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Aliases
for PTMS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Parathymosin1 | | ParaT1 2 |
Export aliases for PTMS gene to outside databasesPrevious GC identifers: GC12M006676 GC12M006801 GC12P006753 GC12P006745 GC12P006746 |
Summaries
for PTMS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PTMS_HUMAN, P20962Function: Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistanceto certain opportunistic infections
Gene Wiki entry for PTMS
|
Genomic Views
for PTMS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PTMS gene promoter:
TBP p53 AP-2alpha isoform 3 AP-2alpha isoform 2 AREB6 FOXO4 deltaCREB AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for PTMS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTMS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13PTMS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P006875: view genomic region
(about GC identifiers)
Start:
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6,874,682 bp from pter |
End:
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6,880,118 bp from pter |
Size:
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5,437 bases |
Orientation:
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plus strand |
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Proteins
for PTMS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PTMS_HUMAN, P20962 (See
protein sequence)Recommended Name: Parathymosin Size: 102 amino acids; 11530 DaExplore the universe of human proteins at neXtProt for PTMS: NX_P20962
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P20962
PTMS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002815.3
ENSEMBL proteins: ENSP00000374113 ENSP00000442325 ENSP00000310088
Human Recombinant Protein Products for PTMS:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PTMS for ontologies About GeneDecksing
PTMS Antibody Products:
Assay Products for PTMS: |
Protein
Domains /
Families
for PTMS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PTMS for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P20962ProtoNet protein and cluster: P20962 1 Blocks protein family: IPB004931 Prothymosin/parathymosin
UniProtKB/Swiss-Prot: PTMS_HUMAN, P20962Similarity: Belongs to the pro/parathymosin family |
Function
for PTMS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PTMS_HUMAN, P20962Function: Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistanceto certain opportunistic infections Genatlas biochemistry entry for PTMS:parathymosin,highly homolog to prothymosin,mainly expressed in liver,kidney,brain,formerly assigned to 17q12-q22
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTMS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTMS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PTMS (NM_002824) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTMS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTMS |
|
Pathways & Interactions
for PTMS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTMS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/11 Interacting proteins for PTMS (P209622, 3 ENSP000003100884) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
PTMS for ontologies About GeneDecksing
|
Drugs & Compounds
for PTMS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PTMS for compounds About GeneDecksing
 Browse Tocris compounds for PTMS
1 Novoseek chemical compound relationship for PTMS gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
18.8 |
1 |
8954154 (1) |
Search CenterWatch for drugs/clinical trials and news about PTMS
|
Transcripts
for PTMS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PTMS gene: NM_002824.4 Unigene Cluster for PTMS: Parathymosin Hs.504613 [show with all ESTs]Unigene Representative Sequence: BM4234406 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000540667 ENST00000389462 ENST00000540874 ENST00000309083(uc001qqq.3)
ENST00000540828 ENST00000538057(uc001qqr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTMS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTMS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PTMS (NM_002824) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PTMS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTMS |
Additional cDNA sequence: BC007616.1 BC017025.1 BC128229.1 21 DOTS entries: DT.97863320 DT.92459184 DT.100788228 DT.91820157 DT.95226559 DT.92459171 DT.100033013 DT.121122888 DT.102829742 DT.95108030 DT.95108035 DT.121122823 DT.121122929 DT.100032121 DT.100044810 DT.121122851 DT.121122855 DT.121456184 DT.87000569 DT.95096549 DT.95288021 5 AceView cDNA sequences: NM_002824 BC017025 BC007616 M24398 Z36803
GeneLoc Exon Structure
|
Expression
for PTMS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PTMS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTGCCCCA
About this image
See PTMS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTMS
SOURCE GeneReport for Unigene cluster: Hs.504613
SABiosciences Custom PCR Arrays for PTMS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTMS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTMS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTMS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTMS |
Orthologs
for PTMS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PTMS gene from 4/7 species (see all 7) About this table
ENSEMBL Gene Tree for PTMS (if available)
TreeFam Gene Tree for PTMS (if available) |
Paralogs
for PTMS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PTMS gene
- PTMA2
PTMS for paralogs About GeneDecksing
|
Genomic Variants
for PTMS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PTMS (6874682 - 6880118 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PTMS
1 CNV: 71451 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTMS |
|
Disorders
/ Diseases
for PTMS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PTMS for disorders About GeneDecksing
OMIM gene information: 168440
OMIM disorders: --
6  diseases for PTMS: About MalaCardshepatitis b prostate carcinoma hepatitis prostatitis
thyroiditis carcinoma
Human Genome Epidemiology (HuGE) Navigator: PTMS (3 documents)
Export disorders for PTMS gene to outside databases
|
Publications
for PTMS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PTMS gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with PTMS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Parathymosin affects the binding of linker histone H1 to nucleosomes and remodels chromatin structure. (PubMed id 15716277)1, 3, 9 Martic G....Papamarcaki T. (2005)
- The sequence of human parathymosin deduced from a cloned human kidney cDNA. (PubMed id 2537638)1, 2 Clinton M.... Horecker B.L. (1989)
- Selective interaction between parathymosin and histone H1. (PubMed id 8954154)1, 9 Kondili K....Papamarcaki T. (1996)
- Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication. (PubMed id 10854063)1, 9 Vareli K....van Driel R. (2000)
- Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ. (PubMed id 1862085)1, 9 Clinton M....Horecker B.L. (1991)
- The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function. (PubMed id 12852257)1, 9 Hannappel E. and Huff T. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
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External Searches for PTMS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTMS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PTMS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTMS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PTMS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PTMS gene:
Search GeneIP for patents involving PTMS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PTMS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PTMS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTMS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTMS | | | OriGene Protein Over-expression Lysate for PTMS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PTMS | | OriGene 3'-UTR Clone for PTMS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTMS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTMS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PTMS | | OriGene Custom Protein Services for PTMS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTMS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTMS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTMS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTMS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTMS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTMS |
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 | | | PTMS Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibody for PTMS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTMS |
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