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Aliases for PTMS Gene

Aliases for PTMS Gene

  • Parathymosin 2 3 5
  • ParaT 3

External Ids for PTMS Gene

Previous GeneCards Identifiers for PTMS Gene

  • GC12M006676
  • GC12M006801
  • GC12P006753
  • GC12P006745
  • GC12P006746
  • GC12P006875

Summaries for PTMS Gene

GeneCards Summary for PTMS Gene

PTMS (Parathymosin) is a Protein Coding gene. Diseases associated with PTMS include ecthyma.

UniProtKB/Swiss-Prot for PTMS Gene

  • Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

Gene Wiki entry for PTMS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTMS Gene

Genomics for PTMS Gene

Regulatory Elements for PTMS Gene

Promoters for PTMS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTMS on UCSC Golden Path with GeneCards custom track

Genomic Location for PTMS Gene

Chromosome:
12
Start:
6,765,516 bp from pter
End:
6,770,952 bp from pter
Size:
5,437 bases
Orientation:
Plus strand

Genomic View for PTMS Gene

Genes around PTMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTMS Gene

Proteins for PTMS Gene

  • Protein details for PTMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20962-PTMS_HUMAN
    Recommended name:
    Parathymosin
    Protein Accession:
    P20962

    Protein attributes for PTMS Gene

    Size:
    102 amino acids
    Molecular mass:
    11530 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTMS Gene

Proteomics data for PTMS Gene at MOPED

Post-translational modifications for PTMS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTMS Gene

No data available for DME Specific Peptides for PTMS Gene

Domains & Families for PTMS Gene

Protein Domains for PTMS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PTMS Gene

Graphical View of Domain Structure for InterPro Entry

P20962

UniProtKB/Swiss-Prot:

PTMS_HUMAN :
  • Belongs to the pro/parathymosin family.
Family:
  • Belongs to the pro/parathymosin family.
genes like me logo Genes that share domains with PTMS: view

No data available for Gene Families for PTMS Gene

Function for PTMS Gene

Molecular function for PTMS Gene

GENATLAS Biochemistry:
parathymosin,highly homolog to prothymosin,mainly expressed in liver,kidney,brain,formerly assigned to 17q12-q22
UniProtKB/Swiss-Prot Function:
Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.
genes like me logo Genes that share phenotypes with PTMS: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTMS Gene

Localization for PTMS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTMS Gene COMPARTMENTS Subcellular localization image for PTMS gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 2
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PTMS Gene

Pathways & Interactions for PTMS Gene

SuperPathways for PTMS Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication TAS 10854063
genes like me logo Genes that share ontologies with PTMS: view

No data available for Pathways by source and SIGNOR curated interactions for PTMS Gene

Drugs & Compounds for PTMS Gene

(1) Drugs for PTMS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PTMS: view

Transcripts for PTMS Gene

mRNA/cDNA for PTMS Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTMS Gene

Parathymosin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTMS Gene

No ASD Table

Relevant External Links for PTMS Gene

GeneLoc Exon Structure for
PTMS
ECgene alternative splicing isoforms for
PTMS

Expression for PTMS Gene

mRNA expression in normal human tissues for PTMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTMS Gene

This gene is overexpressed in Fetal Brain (15.2) and Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTMS Gene



SOURCE GeneReport for Unigene cluster for PTMS Gene Hs.504613

genes like me logo Genes that share expression patterns with PTMS: view

Protein tissue co-expression partners for PTMS Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTMS Gene

Orthologs for PTMS Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTMS Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PTMS 35
  • 93.04 (n)
  • 94.51 (a)
PTMS 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTMS 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTMS 36
  • 100 (a)
OneToOne
Species with no ortholog for PTMS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTMS Gene

ENSEMBL:
Gene Tree for PTMS (if available)
TreeFam:
Gene Tree for PTMS (if available)

Paralogs for PTMS Gene

No data available for Paralogs for PTMS Gene

Variants for PTMS Gene

Sequence variations from dbSNP and Humsavar for PTMS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1882550 -- 6,766,995(+) CGCCG(G/T)CCCCC intron-variant
rs1882551 -- 6,767,122(+) TCTTT(C/G)CTTGC intron-variant
rs2286728 -- 6,765,512(-) CCACT(C/G)CTCAC upstream-variant-2KB
rs2286729 -- 6,764,652(-) CGCTC(C/T)CTCCC upstream-variant-2KB
rs3835030 -- 6,764,686(-) CCCCC(C/G)CCCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTMS Gene

Variant ID Type Subtype PubMed ID
nsv898635 CNV Loss 21882294
nsv832323 CNV Loss 17160897
dgv1352n71 CNV Loss 21882294
esv27720 CNV Loss 19812545

Variation tolerance for PTMS Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTMS Gene

HapMap Linkage Disequilibrium report
PTMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTMS Gene

Disorders for PTMS Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTMS Gene - From: DISEASES

Disorder Aliases PubMed IDs
ecthyma
- elite association - COSMIC cancer census association via MalaCards
Search PTMS in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTMS

Genetic Association Database (GAD)
PTMS
Human Genome Epidemiology (HuGE) Navigator
PTMS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTMS
genes like me logo Genes that share disorders with PTMS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTMS Gene

Publications for PTMS Gene

  1. Parathymosin affects the binding of linker histone H1 to nucleosomes and remodels chromatin structure. (PMID: 15716277) Martic G. … Papamarcaki T. (J. Biol. Chem. 2005) 2 3 23 67
  2. The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function. (PMID: 12852257) Hannappel E. … Huff T. (Vitam. Horm. 2003) 3 23
  3. Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication. (PMID: 10854063) Vareli K. … van Driel R. (Exp. Cell Res. 2000) 3 23
  4. Selective interaction between parathymosin and histone H1. (PMID: 8954154) Kondili K. … Papamarcaki T. (Eur. J. Biochem. 1996) 3 23
  5. Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ. (PMID: 1862085) Clinton M. … Horecker B.L. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 23

Products for PTMS Gene

Sources for PTMS Gene

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