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Aliases for PTMS Gene

Aliases for PTMS Gene

  • Parathymosin 2 3
  • ParaT 3

External Ids for PTMS Gene

Summaries for PTMS Gene

GeneCards Summary for PTMS Gene

PTMS (Parathymosin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PTMS Gene

  • Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections

Gene Wiki entry for PTMS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTMS Gene

Genomics for PTMS Gene

Genomic Location for PTMS Gene

Start:
6,765,516 bp from pter
End:
6,770,952 bp from pter
Size:
5,437 bases
Orientation:
Plus strand

Genomic View for PTMS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTMS Gene

Proteins for PTMS Gene

  • Protein details for PTMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20962-PTMS_HUMAN
    Recommended name:
    Parathymosin
    Protein Accession:
    P20962
    Secondary Accessions:

    Protein attributes for PTMS Gene

    Size:
    102 amino acids
    Molecular mass:
    11530 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTMS Gene

Proteomics data for PTMS Gene at MOPED

Post-translational modifications for PTMS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys15

Other Protein References for PTMS Gene

No data available for DME Specific Peptides for PTMS Gene

Domains for PTMS Gene

Protein Domains for PTMS Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PTMS_HUMAN
Family:
  • Belongs to the pro/parathymosin family.:
    • P20962
genes like me logo Genes that share domains with PTMS: view

No data available for Gene Families for PTMS Gene

Function for PTMS Gene

Molecular function for PTMS Gene

GENATLAS Biochemistry: parathymosin,highly homolog to prothymosin,mainly expressed in liver,kidney,brain,formerly assigned to 17q12-q22
UniProtKB/Swiss-Prot Function: Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PTMS Gene

Localization for PTMS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTMS Gene COMPARTMENTS Subcellular localization image for PTMS gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PTMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10854063
genes like me logo Genes that share ontologies with PTMS: view

Pathways for PTMS Gene

SuperPathways for PTMS Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006260 DNA replication TAS 10854063
genes like me logo Genes that share ontologies with PTMS: view

No data available for Pathways by source for PTMS Gene

Compounds for PTMS Gene

(1) Novoseek inferred chemical compound relationships for PTMS Gene

Compound -log(P) Hits PubMed IDs
zinc 18.8 1
genes like me logo Genes that share compounds with PTMS: view

Transcripts for PTMS Gene

mRNA/cDNA for PTMS Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTMS Gene

Parathymosin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTMS Gene

No ASD Table

Relevant External Links for PTMS Gene

GeneLoc Exon Structure for
PTMS
ECgene alternative splicing isoforms for
PTMS

Expression for PTMS Gene

mRNA expression in normal human tissues for PTMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTMS Gene

SOURCE GeneReport for Unigene cluster for PTMS Gene Hs.504613

genes like me logo Genes that share expressions with PTMS: view

Orthologs for PTMS Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTMS 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTMS 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTMS 36
  • 93.04 (n)
  • 94.51 (a)
PTMS 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptms 16
Species with no ortholog for PTMS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTMS Gene

ENSEMBL:
Gene Tree for PTMS (if available)
TreeFam:
Gene Tree for PTMS (if available)

Paralogs for PTMS Gene

No data available for Paralogs for PTMS Gene

Variants for PTMS Gene

Sequence variations from dbSNP and Humsavar for PTMS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1058410 -- 6,770,445(+) TGAGC(C/G)CCTGC utr-variant-3-prime
rs1882550 -- 6,766,995(+) CGCCG(G/T)CCCCC intron-variant
rs1882551 -- 6,767,122(+) TCTTT(C/G)CTTGC intron-variant
rs2286728 -- 6,765,512(-) CCACT(C/G)CTCAC upstream-variant-2KB
rs2286729 -- 6,764,652(-) CGCTC(C/T)CTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTMS Gene

Variant ID Type Subtype PubMed ID
nsv898635 CNV Loss 21882294
nsv832323 CNV Loss 17160897
dgv1352n71 CNV Loss 21882294
esv27720 CNV Loss 19812545

Relevant External Links for PTMS Gene

HapMap Linkage Disequilibrium report
PTMS

Disorders for PTMS Gene

Relevant External Links for PTMS

Genetic Association Database (GAD)
PTMS
Human Genome Epidemiology (HuGE) Navigator
PTMS
genes like me logo Genes that share disorders with PTMS: view

No data available for UniProtKB/Swiss-Prot for PTMS Gene

Publications for PTMS Gene

  1. Parathymosin affects the binding of linker histone H1 to nucleosomes and remodels chromatin structure. (PMID: 15716277) Martic G. … Papamarcaki T. (J. Biol. Chem. 2005) 2 3 23
  2. The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function. (PMID: 12852257) Hannappel E. … Huff T. (Vitam. Horm. 2003) 3 23
  3. Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ. (PMID: 1862085) Clinton M. … Horecker B.L. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 23
  4. Selective interaction between parathymosin and histone H1. (PMID: 8954154) Kondili K. … Papamarcaki T. (Eur. J. Biochem. 1996) 3 23
  5. Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication. (PMID: 10854063) Vareli K. … van Driel R. (Exp. Cell Res. 2000) 3 23

Products for PTMS Gene

Sources for PTMS Gene

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