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Aliases for PTMA Gene

Aliases for PTMA Gene

  • Prothymosin, Alpha 2 3 5
  • Gene Sequence 28 2 3
  • TMSA 3 4
  • Prothymosin, Alpha (Gene Sequence 28) 2
  • Prothymosin Alpha Protein 3
  • Prothymosin Alpha 3

External Ids for PTMA Gene

Previous HGNC Symbols for PTMA Gene

  • TMSA

Previous GeneCards Identifiers for PTMA Gene

  • GC02P230632
  • GC02P231306
  • GC02P232536
  • GC02P232775
  • GC02P232398
  • GC02P232281
  • GC02P232571

Summaries for PTMA Gene

GeneCards Summary for PTMA Gene

PTMA (Prothymosin, Alpha) is a Protein Coding gene. Diseases associated with PTMA include Hepatitis B and Thymoma. Among its related pathways are Validated targets of C-MYC transcriptional activation and Epstein-Barr virus infection.

UniProtKB/Swiss-Prot for PTMA Gene

  • Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

Gene Wiki entry for PTMA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTMA Gene

Genomics for PTMA Gene

Regulatory Elements for PTMA Gene

Enhancers for PTMA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F231611 1.8 FANTOM5 Ensembl ENCODE 3.5 -92.3 -92263 7.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS TEX44 NMUR1 LINC00471 PTMA DIS3L2 LOC105373928 RN7SL499P
GH02F231602 1.7 FANTOM5 Ensembl ENCODE 2.6 -101.9 -101938 4.1 HDGF PKNOX1 ATF1 SIN3A ARID4B BRCA1 GLIS2 SP3 REST ZNF592 RPL28P2 NMUR1 LINC00471 DIS3L2 PTMA GC02P231604 PIR57970
GH02F231713 1.6 FANTOM5 Ensembl ENCODE 2.2 +9.0 8993 5.0 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RPL28P2 PTMA NCL ENSG00000277986 GC02M231725
GH02F231669 1.7 FANTOM5 Ensembl ENCODE 1.9 -33.7 -33663 6.9 HDGF PKNOX1 WRNIP1 ZFP64 SIN3A YBX1 ZNF48 ETS1 GLIS2 ZNF143 RPL28P2 PTMA DIS3L2 GC02M231678 RN7SL499P
GH02F231679 1.8 FANTOM5 Ensembl ENCODE 1.6 -24.4 -24365 6.5 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 RNU2-22P NPPC COPS7B PTMA GC02M231678 MIR1244-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTMA on UCSC Golden Path with GeneCards custom track

Promoters for PTMA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001662344 1905 6001 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1

Genomic Location for PTMA Gene

Chromosome:
2
Start:
231,706,895 bp from pter
End:
231,713,541 bp from pter
Size:
6,647 bases
Orientation:
Plus strand

Genomic View for PTMA Gene

Genes around PTMA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTMA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTMA Gene

Proteins for PTMA Gene

  • Protein details for PTMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06454-PTMA_HUMAN
    Recommended name:
    Prothymosin alpha
    Protein Accession:
    P06454
    Secondary Accessions:
    • Q15249
    • Q15592

    Protein attributes for PTMA Gene

    Size:
    111 amino acids
    Molecular mass:
    12203 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTMA Gene

    Alternative splice isoforms for PTMA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTMA Gene

Post-translational modifications for PTMA Gene

No data available for DME Specific Peptides for PTMA Gene

Domains & Families for PTMA Gene

Protein Domains for PTMA Gene

Graphical View of Domain Structure for InterPro Entry

P06454

UniProtKB/Swiss-Prot:

PTMA_HUMAN :
  • Belongs to the pro/parathymosin family.
Family:
  • Belongs to the pro/parathymosin family.
genes like me logo Genes that share domains with PTMA: view

No data available for Gene Families for PTMA Gene

Function for PTMA Gene

Molecular function for PTMA Gene

GENATLAS Biochemistry:
prothymosin alpha,widely expressed,abundant audic nuclear protein potential modulator of the interaction of histone 1 with chromatin
UniProtKB/Swiss-Prot Function:
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

Gene Ontology (GO) - Molecular Function for PTMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15607035
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with PTMA: view
genes like me logo Genes that share phenotypes with PTMA: view

Animal Model Products

miRNA for PTMA Gene

miRTarBase miRNAs that target PTMA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTMA Gene

Localization for PTMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTMA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTMA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for PTMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 10854063
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PTMA: view

Pathways & Interactions for PTMA Gene

genes like me logo Genes that share pathways with PTMA: view

Pathways by source for PTMA Gene

1 BioSystems pathway for PTMA Gene
1 KEGG pathway for PTMA Gene

Gene Ontology (GO) - Biological Process for PTMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 10854063
GO:0043486 histone exchange IEA --
genes like me logo Genes that share ontologies with PTMA: view

No data available for SIGNOR curated interactions for PTMA Gene

Drugs & Compounds for PTMA Gene

(19) Drugs for PTMA Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thymalfasin Approved, Investigational Pharma 27

(3) Additional Compounds for PTMA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTMA: view

Transcripts for PTMA Gene

Unigene Clusters for PTMA Gene

Prothymosin, alpha:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTMA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2:
SP3: -
SP4: - -

Relevant External Links for PTMA Gene

GeneLoc Exon Structure for
PTMA
ECgene alternative splicing isoforms for
PTMA

Expression for PTMA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTMA Gene

Protein differential expression in normal tissues from HIPED for PTMA Gene

This gene is overexpressed in Oral epithelium (12.7), Fetal Brain (11.4), and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTMA Gene



Protein tissue co-expression partners for PTMA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTMA Gene:

PTMA

SOURCE GeneReport for Unigene cluster for PTMA Gene:

Hs.459927
genes like me logo Genes that share expression patterns with PTMA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTMA Gene

Orthologs for PTMA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTMA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTMA 34
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia PTMA 35 35
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ptma 35
  • 95 (a)
OneToMany
Gm6625 35
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PTMA 34 35
  • 92.42 (n)
-- 35
  • 88 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PTMA 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTMA 35
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ptma-prov 34
zebrafish
(Danio rerio)
Actinopterygii ptma 34
Species where no ortholog for PTMA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTMA Gene

ENSEMBL:
Gene Tree for PTMA (if available)
TreeFam:
Gene Tree for PTMA (if available)

Paralogs for PTMA Gene

genes like me logo Genes that share paralogs with PTMA: view

No data available for Paralogs for PTMA Gene

Variants for PTMA Gene

Sequence variations from dbSNP and Humsavar for PTMA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10175813 -- 231,711,859(+) AGCTG(A/G)TAATG intron-variant, upstream-variant-2KB
rs1058315 -- 231,709,234(+) GGCCG(C/G)CGGTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1058316 -- 231,709,410(+) GTGCG(C/T)CGGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1059834 -- 231,711,939(+) agaag(A/G)ggaag intron-variant, upstream-variant-2KB, reference, missense
rs1060635 -- 231,713,184(+) CTCGG(A/G)TGACC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTMA Gene

Variant ID Type Subtype PubMed ID
nsv979182 CNV duplication 23825009
nsv834568 CNV loss 17160897
nsv428408 CNV gain+loss 18775914
nsv3204 CNV deletion 18451855
esv2759117 CNV gain+loss 17122850

Variation tolerance for PTMA Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTMA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTMA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTMA Gene

Disorders for PTMA Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTMA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
thymoma
  • thymus neoplasms
invasive malignant thymoma
  • infiltrating thymoma
- elite association - COSMIC cancer census association via MalaCards
Search PTMA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTMA

Genetic Association Database (GAD)
PTMA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTMA
genes like me logo Genes that share disorders with PTMA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTMA Gene

Publications for PTMA Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  2. Effects of zinc binding on the structure and dynamics of the intrinsically disordered protein prothymosin alpha: evidence for metalation as an entropic switch. (PMID: 17929838) Yi S. … Choy W.Y. (Biochemistry 2007) 3 22 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2. (PMID: 7916742) Szabo P. … Horecker B.L. (Hum. Genet. 1993) 3 4 64

Products for PTMA Gene

Sources for PTMA Gene

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