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Aliases for PTK7 Gene

Aliases for PTK7 Gene

  • Protein Tyrosine Kinase 7 (Inactive) 2 3
  • Colon Carcinoma Kinase 4 2 3 4
  • Pseudo Tyrosine Kinase Receptor 7 3 4
  • PTK7 Protein Tyrosine Kinase 7 2 3
  • Tyrosine-Protein Kinase-Like 7 3 4
  • CCK-4 3 4
  • CCK4 3 4
  • Inactive Tyrosine-Protein Kinase 7 3
  • Protein Tyrosine Kinase 7 2
  • Protein-Tyrosine Kinase 7 4

External Ids for PTK7 Gene

Summaries for PTK7 Gene

Entrez Gene Summary for PTK7 Gene

  • This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PTK7 Gene

PTK7 (Protein Tyrosine Kinase 7 (Inactive)) is a Protein Coding gene. Diseases associated with PTK7 include panic disorder and agoraphobia. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot for PTK7 Gene

  • Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Gene Wiki entry for PTK7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTK7 Gene

Genomics for PTK7 Gene

Genomic Location for PTK7 Gene

Start:
43,076,268 bp from pter
End:
43,161,720 bp from pter
Size:
85,453 bases
Orientation:
Plus strand

Genomic View for PTK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTK7 Gene

Regulatory Elements for PTK7 Gene

Proteins for PTK7 Gene

  • Protein details for PTK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13308-PTK7_HUMAN
    Recommended name:
    Inactive tyrosine-protein kinase 7
    Protein Accession:
    Q13308
    Secondary Accessions:
    • A8K974
    • B7Z477
    • E9PFZ5
    • Q13417
    • Q5T650
    • Q6IQ54
    • Q8NFA5
    • Q8NFA6
    • Q8NFA7
    • Q8NFA8

    Protein attributes for PTK7 Gene

    Size:
    1070 amino acids
    Molecular mass:
    118392 Da
    Quaternary structure:
    • Interacts with CTNNB1.

    Alternative splice isoforms for PTK7 Gene

neXtProt entry for PTK7 Gene

Proteomics data for PTK7 Gene at MOPED

Post-translational modifications for PTK7 Gene

  • MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn116, Asn175, Asn184, Asn214, Asn268, Asn283, Asn405, Asn463, Asn567, and Asn646

No data available for DME Specific Peptides for PTK7 Gene

Domains for PTK7 Gene

Gene Families for PTK7 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

PTK7_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive:
    • Q13308
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q13308
  • Contains 1 protein kinase domain.:
    • Q13308
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.:
    • Q13308
genes like me logo Genes that share domains with PTK7: view

Function for PTK7 Gene

Molecular function for PTK7 Gene

GENATLAS Biochemistry: protein tyrosine kinase 7,expressed in K-562,human leukemia cell and liver
UniProtKB/Swiss-Prot Function: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
UniProtKB/Swiss-Prot Induction: Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines established from highly metastatic invasive carcinomas (at protein level).

Gene Ontology (GO) - Molecular Function for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity --
GO:0005515 protein binding IPI 21132015
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PTK7: view
genes like me logo Genes that share phenotypes with PTK7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PTK7 Gene

Localization for PTK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTK7 Gene

Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTK7 Gene COMPARTMENTS Subcellular localization image for PTK7 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 7478540
GO:0005911 cell-cell junction IDA 20837484
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PTK7: view

Pathways for PTK7 Gene

genes like me logo Genes that share pathways with PTK7: view

Pathways by source for PTK7 Gene

1 Cell Signaling Technology pathway for PTK7 Gene

Gene Ontology (GO) - Biological Process for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001736 establishment of planar polarity IBA --
GO:0001843 neural tube closure IEA --
GO:0003401 axis elongation IBA --
GO:0006468 protein phosphorylation --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with PTK7: view

Compounds for PTK7 Gene

(2) HMDB Compounds for PTK7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(19) Novoseek inferred chemical compound relationships for PTK7 Gene

Compound -log(P) Hits PubMed IDs
cholecystokinin tetrapeptide 98.5 28
tetrapeptide 92.6 56
asperlicin 80.3 1
acth 59.2 15
alprazolam 44.8 2
genes like me logo Genes that share compounds with PTK7: view

Transcripts for PTK7 Gene

Unigene Clusters for PTK7 Gene

Protein tyrosine kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTK7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10:
SP11: - - - - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 16a · 16b · 16c · 16d ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8:
SP9: - - - - -
SP10: - -
SP11: - - - - -
SP12:
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - - -
SP16: -
SP17:
SP18:
SP19: - -

Relevant External Links for PTK7 Gene

GeneLoc Exon Structure for
PTK7
ECgene alternative splicing isoforms for
PTK7

Expression for PTK7 Gene

mRNA expression in normal human tissues for PTK7 Gene

mRNA differential expression in normal tissues according to GTEx for PTK7 Gene

This gene is overexpressed in Uterus (5.4) and Ovary (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTK7 Gene

SOURCE GeneReport for Unigene cluster for PTK7 Gene Hs.90572

mRNA Expression by UniProt/SwissProt for PTK7 Gene

Q13308-PTK7_HUMAN
Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon
genes like me logo Genes that share expressions with PTK7: view

Orthologs for PTK7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTK7 36
  • 98.97 (n)
  • 98.87 (a)
PTK7 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTK7 36
  • 89.51 (n)
  • 93.49 (a)
PTK7 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTK7 36
  • 89.48 (n)
  • 93.49 (a)
PTK7 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptk7 36
  • 87.79 (n)
  • 92.61 (a)
Ptk7 16
Ptk7 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTK7 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTK7 36
  • 69.3 (n)
  • 66.39 (a)
PTK7 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTK7 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487595 36
  • 70.31 (n)
  • 70.78 (a)
zebrafish
(Danio rerio)
Actinopterygii ptk7a 37
  • 60 (a)
OneToOne
ptk7b 36
  • 62.28 (n)
  • 53.15 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011489 36
  • 49.28 (n)
  • 38.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8964 37
  • 26 (a)
OneToMany
otk 36
  • 47.45 (n)
  • 34.8 (a)
otk 37
  • 28 (a)
OneToMany
otk 38
  • 44 (a)
CG8964 38
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToOne
Species with no ortholog for PTK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTK7 Gene

ENSEMBL:
Gene Tree for PTK7 (if available)
TreeFam:
Gene Tree for PTK7 (if available)

Paralogs for PTK7 Gene

Paralogs for PTK7 Gene

genes like me logo Genes that share paralogs with PTK7: view

Variants for PTK7 Gene

Sequence variations from dbSNP and Humsavar for PTK7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1034246 -- 43,100,632(-) CACGG(A/C)CAAAT intron-variant
rs1051709 -- 43,161,114(+) AGTTT(C/T)CCCTG utr-variant-3-prime, nc-transcript-variant
rs1105024 -- 43,116,036(-) AGAGC(C/T)ACGAG intron-variant
rs1109942 -- 43,078,613(-) AACAG(G/T)GGGAT intron-variant
rs1537638 -- 43,128,461(+) CTTTG(C/T)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTK7 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990
nsv437509 CNV Loss 16327808
nsv462932 CNV Loss 19166990
nsv521730 CNV Loss 19592680

Relevant External Links for PTK7 Gene

HapMap Linkage Disequilibrium report
PTK7
Human Gene Mutation Database (HGMD)
PTK7

Disorders for PTK7 Gene

(2) University of Copenhagen DISEASES for PTK7 Gene

(10) Novoseek inferred disease relationships for PTK7 Gene

Disease -log(P) Hits PubMed IDs
panic 91.9 73
panic attacks 91.5 44
panic disorder 86.7 43
premenstrual dysphoric disorder 47.5 3
effects cardiovascular 34.5 3

Relevant External Links for PTK7

Genetic Association Database (GAD)
PTK7
genes like me logo Genes that share disorders with PTK7: view

No data available for UniProtKB/Swiss-Prot for PTK7 Gene

Publications for PTK7 Gene

  1. Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. (PMID: 7478540) Mossie K. … Ullrich A. (Oncogene 1995) 2 3 4 23
  2. Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA. (PMID: 12427550) Jung J.-W. … Lee S.-T. (Biochim. Biophys. Acta 2002) 3 4 23
  3. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. (PMID: 8882711) Park S.-K. … Lee S.-T. (J. Biochem. 1996) 3 4 23
  4. Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. (PMID: 18471990) Shin W.-S. … Lee S.-T. (Biochem. Biophys. Res. Commun. 2008) 3 4
  5. The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome. (PMID: 20558616) Prebet T. … Borg J.-P. (Blood 2010) 3 4

Products for PTK7 Gene

  • Addgene plasmids for PTK7

Sources for PTK7 Gene

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