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PTK7 Gene

protein-coding   GIFtS: 65
GCID: GC06P043044

Protein Tyrosine Kinase 7

(Previous name: PTK7 protein tyrosine kinase 7)
  See PTK7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Kinase 71 2     CCK-42 3
PTK7 Protein Tyrosine Kinase 71 2     CCK42 3
Colon Carcinoma Kinase 42 3     Inactive Tyrosine-Protein Kinase 72
Pseudo Tyrosine Kinase Receptor 72 3     Protein-Tyrosine Kinase 73
Tyrosine-Protein Kinase-Like 72 3     

External Ids:    HGNC: 96181   Entrez Gene: 57542   Ensembl: ENSG000001126557   OMIM: 6018905   UniProtKB: Q133083   

Export aliases for PTK7 gene to outside databases

Previous GC identifers: GC06P043046 GC06P043090 GC06P043153 GC06P042761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTK7 Gene:
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular
signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is
involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and
adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Jul 2012)

GeneCards Summary for PTK7 Gene:
PTK7 (protein tyrosine kinase 7) is a protein-coding gene. Diseases associated with PTK7 include panic disorder, and agoraphobia. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308
Function: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also
known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell
adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a
role in embryogenesis, epithelial tissue organization and angiogenesis

Gene Wiki entry for PTK7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTK7 gene promoter:
         GR   Sox5   GATA-3   Bach2   GR-beta   RelA   GR-alpha   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTK7 promoter sequence
   Search Chromatin IP Primers for PTK7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1-p12.2   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1-p12.2

PTK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTK7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043044:  view genomic region     (about GC identifiers)

Start:
43,044,006 bp from pter      End:
43,129,457 bp from pter
Size:
85,452 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308 (See protein sequence)
Recommended Name: Inactive tyrosine-protein kinase 7 precursor  
Size: 1070 amino acids; 118392 Da
Subunit: Interacts with CTNNB1
Secondary accessions: A8K974 B7Z477 E9PFZ5 Q13417 Q5T650 Q6IQ54 Q8NFA5 Q8NFA6 Q8NFA7 Q8NFA8
Alternative splicing: 6 isoforms:  Q13308-1   Q13308-2   Q13308-3   Q13308-4   Q13308-5   Q13308-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTK7: NX_Q13308

Explore proteomics data for PTK7 at MOPED

Post-translational modifications: 

  • MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane
    C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway1
  • Glycosylation2 at Asn116, Asn175, Asn184, Asn214, Asn268, Asn283, Asn405, Asn463, Asn567, Asn646
  • Modification sites at PhosphoSitePlus

  • See PTK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257327.1  NP_002812.2  NP_690619.1  NP_690620.1  NP_690621.1  

    ENSEMBL proteins: 
     ENSP00000230419   ENSP00000417607   ENSP00000420322   ENSP00000419037   ENSP00000325462  
     ENSP00000326029   ENSP00000325992   ENSP00000230418   ENSP00000418754   ENSP00000420165  
     ENSP00000420765   ENSP00000418545   ENSP00000419096   ENSP00000418462   ENSP00000420186  
     ENSP00000418386  

    PTK7 Human Recombinant Protein Products:

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    Novus Biologicals PTK7 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PTK7 

    PTK7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTK7
    R&D Systems Antibodies for PTK7 (PTK7/CCK4)
    Cell Signaling Technology (CST) Antibodies for PTK7  (CCK4)
    OriGene Antibodies for PTK7
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    LSBio Antibodies in human, mouse, rat for PTK7

    PTK7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PTK7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: PTK7 protein tyrosine kinase 7
    CCK4 family
    ROR family and other RTKs

    Selected InterPro protein domains (see all 10):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13308

    ProtoNet protein and cluster: Q13308

    4 Blocks protein domains:
    IPB002011 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PTK7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTK7_HUMAN, Q13308
    Function: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also
    known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell
    adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a
    role in embryogenesis, epithelial tissue organization and angiogenesis
    Induction: Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines
    established from highly metastatic invasive carcinomas (at protein level)

         Genatlas biochemistry entry for PTK7:
    protein tyrosine kinase 7,expressed in K-562,human leukemia cell and liver

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS8882711
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PTK7           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTK7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased mitotic index 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ptk7):
     behavior/neurological  cardiovascular system  craniofacial  embryogenesis  growth/size/body 
     hearing/vestibular/ear  limbs/digits/tail  mortality/aging  nervous system  renal/urinary system 
     respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with PTK7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTK7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTK7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTK7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTK7

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTK7:
    hsa-mir-92a-3p (MIRT049679), hsa-mir-324-5p (MIRT043228), hsa-mir-7-5p (MIRT025958), hsa-mir-193b-3p (MIRT041454), hsa-mir-124-3p (MIRT023149)

    Block miRNA regulation of human, mouse, rat PTK7 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PTK7:
    hsa-miR-205 hsa-miR-409-5p hsa-miR-3141 hsa-miR-2278 hsa-miR-503 hsa-miR-452*
    SwitchGear 3'UTR luciferase reporter plasmidPTK7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTK7
    Predesigned siRNA for gene silencing in human, mouse, rat PTK7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTK7

    Clone
    Products:
         
    OriGene clones in human, mouse for PTK7 (see all 26)
    OriGene ORF clones in mouse, rat for PTK7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK7 (NM_152880)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK7
    Addgene plasmids for PTK7 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PTK7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTK7_HUMAN, Q13308: Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at
    cell junctions. Also localizes at the leading edge of migrating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS7478540
    GO:0005911cell-cell junction IDA--
    GO:0016020membrane ----

    Find genes that share ontologies with PTK7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTK7 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71


    Find genes that share SuperPaths with PTK7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTK7 (see all 29)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for PTK7
        Tyrosine Kinases / Adaptors


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTK7
    Interactions:

        Search GeneGlobe Interaction Network for PTK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for PTK7 (Q133081, 2, 3 ENSP000002304194) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-2803245,EBI-491549 MINT-8114708 MINT-8114662 MINT-8114684 MINT-8114810 MINT-8114644 I2D: score=1 STRING: ENSP00000344456
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    WNT9BO149053, ENSP000002900154I2D: score=1 STRING: ENSP00000290015
    DVL2O146413, ENSP000000053404I2D: score=1 STRING: ENSP00000005340
    WNT9AENSP000002721644STRING: ENSP00000272164
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001736establishment of planar polarity IEA--
    GO:0001843neural tube closure IEA--
    GO:0003401axis elongation IEA--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with PTK7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTK7

    2 HMDB Compounds for PTK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for PTK7 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholecystokinin tetrapeptide 98.5 28 15467707 (2), 1911739 (1), 9755359 (1), 8771610 (1) (see all 27)
    tetrapeptide 92.6 57 15706463 (2), 8458396 (1), 8880078 (1), 9285937 (1) (see all 55)
    asperlicin 80.3 1 12789687 (1)
    acth 59.2 17 10840174 (3), 10664826 (2), 16817979 (2), 9335081 (1) (see all 11)
    alprazolam 44.8 2 12700707 (2)
    gaba 36.2 12 12658378 (6), 17109076 (3)
    5-hydroxytryptophan 35 2 15346539 (1), 15260907 (1)
    vigabatrin 32.7 2 11682253 (2)
    citalopram 23.3 5 16541242 (3), 9401314 (2)
    benzodiazepine 15.8 6 7838917 (3)



    Find genes that share compounds with PTK7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTK7 gene (6 alternative transcripts): 
    NM_001270398.1  NM_002821.4  NM_152880.3  NM_152881.3  NM_152882.3  NM_152883.1  

    Unigene Cluster for PTK7:

    Protein tyrosine kinase 7
    Hs.90572  [show with all ESTs]
    Unigene Representative Sequence: NM_002821
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000230419(uc003oub.1 uc003ouc.1 uc003oud.1 uc003oue.1 uc003ouf.1 uc003oug.1 uc011dve.1)
    ENST00000476760 ENST00000470019(uc010jyj.1) ENST00000471863(uc003oua.3)
    ENST00000349241 ENST00000352931 ENST00000345201 ENST00000230418 ENST00000487673
    ENST00000481273 ENST00000481946 ENST00000490710 ENST00000489707 ENST00000470471
    ENST00000493339 ENST00000461100 ENST00000494146 ENST00000497957
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate PTK7:
    hsa-miR-205 hsa-miR-409-5p hsa-miR-3141 hsa-miR-2278 hsa-miR-503 hsa-miR-452*
    SwitchGear 3'UTR luciferase reporter plasmidPTK7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTK7
    Clone
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    OriGene ORF clones in mouse, rat for PTK7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK7 (NM_152880)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK7
    Addgene plasmids for PTK7 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTK7
      QuantiTect SYBR Green Assays in human, mouse, rat PTK7
      QuantiFast Probe-based Assays in human, mouse, rat PTK7

    Additional mRNA sequence: 

    AF531868.1 AF531869.1 AF531870.1 AF531871.1 AF531872.1 AK055648.1 AK124108.1 AK291016.1 
    AK292589.1 AK296931.1 AK296953.1 AL157486.1 BC002377.2 BC014626.2 BC046109.2 BC071557.1 
    NR_072997.1 NR_072998.1 U33635.1 U40271.2 

    21 DOTS entries:

    DT.95315961  DT.100028547  DT.92454201  DT.100028554  DT.100788727  DT.102833039  DT.99930053  DT.95286308 
    DT.100028548  DT.100788728  DT.100804885  DT.70102513  DT.100028549  DT.95291408  DT.95291444  DT.100753629 
    DT.121376098  DT.316354  DT.80100210  DT.92454195  DT.95291438 

    Selected AceView cDNA sequences (see all 253):

    BC071557 AU279814 AA669430 AI140260 AX748119 BQ028740 AI335972 AI817752 
    AW297907 NM_152881 BM048660 BM970687 AF531872 NM_152883 BM970585 AW593617 
    AA634328 AK093428 AL157665 BU633454 BX477790 BM974330 AI306512 CD514588 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTK7 (see all 19)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
    SP1:        -                                         -                       -     -                                                                       -   
    SP2:        -                 -     -                 -                       -     -                                                                       -   
    SP3:        -                                         -                       -     -                                                           -     -     -   
    SP4:        -                                         -                       -     -                                                                       -   
    SP5:        -                                         -                       -     -                                   -     -                             -   

    ExUns: 16a · 16b · 16c · 16d ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
    SP1:  -     -     -           -     -                 -                       -                                       
    SP2:  -     -     -           -     -                 -                       -                                       
    SP3:  -     -     -           -     -                 -                       -                                       
    SP4:  -     -     -           -     -                 -     -     -     -     -                                       
    SP5:  -     -     -           -     -                 -                       -                                       


    ECgene alternative splicing isoforms for PTK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PTK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGTAGGG
    PTK7 Expression
    About this image

    PTK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTK7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90572

    UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308
    Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed
    in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not
    expressed in colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTK7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptk71 , 5 PTK7 protein tyrosine kinase 71, 5 87.79(n)1
    92.61(a)1
      17 (22.90 cM)5
    714611  NM_175168.41  NP_780377.11 
     465644515 
    chicken
    (Gallus gallus)
    Aves PTK71 PTK7 protein tyrosine kinase 7 69.3(n)
    66.39(a)
      421257  NM_001031035.1  NP_001026206.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTK76
    protein tyrosine kinase 7
    69(a)
    1 ↔ 1
    2(143967944-144090337)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060500.12   -- 76.41(n)    BC060500.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ptk7b1 protein tyrosine kinase 7b 62.28(n)
    53.15(a)
      100150035  XM_005173043.1  XP_005173100.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta otk1 , 3 axon guidance cell adhesion receptor3
    off-track1
    44(a)
    (best of 2)3
    47.45(n)1
    34.8(a)1
      362831  NM_078981.21  NP_523705.21 


    ENSEMBL Gene Tree for PTK7 (if available)
    TreeFam Gene Tree for PTK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTK7 gene
    IGSF102  NCAM22  ENSG000002154282  MXRA52  NCAM12  
    Selected SIMAP similar genes for PTK7 using alignment to 10 protein entries:     PTK7_HUMAN (see all proteins) (see all similar genes):
    DKFZp434L0319    MET    EZR-ROS1    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1    R32
    R34    SLC34A2-ROS1    TPM3-ROS1    AURKC    NTRK1    ABL1
    BRAF    FGR    LTK    MUSK    A20    EML4-ALK

    Find genes that share paralogs with PTK7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTK7 (see all 1859)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0415084
    A colorectal adenocarcinoma sample4--see VAR_0415082 A V mis40--------
    rs1166578571,2
    C,F--43043336(+) TTTCAC/TAACAA 7 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1836403431,2
    --43043451(+) AGACTG/TCCTGG 7 -- us2k10--------
    rs1876777151,2
    --43043862(+) GTCCCC/GTGCAC 7 -- us2k10--------
    rs1909528651,2
    --43043911(+) CAGACC/TCCTCC 7 -- us2k10--------
    rs1835246081,2
    --43044171(+) CGCGGA/GGCGCA 7 -- ut51 us2k1 nc-transcript-variant0--------
    rs2012494741,2
    C--43044233(+) TGGGAC/GCTGCG 11 P A mis1 us2k10--------
    rs1510169191,2
    --43044494(+) GCCTCC/TAGGGA 7 -- int1 us2k10--------
    rs1866630121,2
    --43044598(+) TGCCGA/CGAGTT 7 -- int1 ut510--------
    rs734364291,2
    C,F--43044620(+) GGCCCA/GGATGG 7 -- int1 ut517Minor allele frequency- G:0.07WA NA EA 366

    HapMap Linkage Disequilibrium report for PTK7 (43044006 - 43129457 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PTK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462932CNV Loss19166990
    nsv462930CNV Loss19166990
    nsv437509CNV Loss16327808
    nsv521730CNV Loss19592680
    nsv462927CNV Loss19166990

    Human Gene Mutation Database (HGMD): PTK7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTK7
    DNA2.0 Custom Variant and Variant Library Synthesis for PTK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601890    OMIM disorders: --

    3 diseases for PTK7:    
    About MalaCards
    panic disorder    agoraphobia    social phobia

    2 diseases from the University of Copenhagen DISEASES database for PTK7:
    Panic disorder     Agoraphobia

    Find genes that share disorders with PTK7           About GenesLikeMe

    10 Novoseek inferred disease relationships for PTK7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    panic 91.9 90 15467707 (5), 18534623 (3), 16817979 (3), 17035932 (3) (see all 45)
    panic attacks 91.5 47 9085405 (4), 11668667 (4), 10693152 (2), 19289240 (2) (see all 34)
    panic disorder 86.7 45 1467375 (3), 18534623 (2), 7855203 (2), 10693152 (2) (see all 34)
    premenstrual dysphoric disorder 47.5 5 9885787 (2), 11457531 (1)
    effects cardiovascular 34.5 4 7838917 (1), 8886299 (1), 10082241 (1)
    agoraphobia 30.7 1 8771610 (1)
    anxiety disorders 30.1 1 2180549 (1)
    colon carcinoma 20.7 5 7478540 (2), 17173930 (1), 15683231 (1)
    psychiatric disorder 0 1 10631762 (1)
    schizophrenia 0 1 11803530 (1)

    Genetic Association Database (GAD): PTK7

    Export disorders for PTK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTK7 gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with PTK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. (PubMed id 7478540)1, 2, 3, 9 Mossie K.... Ullrich A. (Oncogene 1995)
    2. Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA. (PubMed id 12427550)1, 2, 9 Jung J.-W.... Lee S.-T. (Biochim. Biophys. Acta 2002)
    3. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. (PubMed id 8882711)1, 2, 9 Park S.-K.... Lee S.-T. (J. Biochem. 1996)
    4. Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling. (PubMed id 21132015)1, 2 Puppo F.... Borg J.-P. (EMBO Rep. 2011)
    5. Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway. (PubMed id 21103379)1, 2 Meng L.... Tan W. (PLoS ONE 2010)
    6. The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome. (PubMed id 20558616)1, 2 Prebet T.... Borg J.-P. (Blood 2010)
    7. The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. (PubMed id 20837484)1, 2 Golubkov V.S.... Strongin A.Y. (J. Biol. Chem. 2010)
    8. Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. (PubMed id 18471990)1, 2 Shin W.-S.... Lee S.-T. (Biochem. Biophys. Res. Commun. 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5754 HGNC: 9618 AceView: PTK7 Ensembl:ENSG00000112655 euGenes: HUgn5754
    ECgene: PTK7 H-InvDB: PTK7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTK7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTK7 gene:
    Search GeneIP for patents involving PTK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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