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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTK7 Gene

protein-coding   GIFtS: 62
GCID: GC06P043044

protein tyrosine kinase 7

(Previous name: PTK7 protein tyrosine kinase 7 )
 Explore 23 diseases affiliated with
PTK7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTK7    

Aliases
for PTK7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Kinase 71 2     Tyrosine-Protein Kinase-Like 72 3
CCK41 2 3     CCK-42 3
PTK7 Protein Tyrosine Kinase 71 2     Inactive Tyrosine-Protein Kinase 72
Colon Carcinoma Kinase 42 3     Protein-Tyrosine Kinase 73
Pseudo Tyrosine Kinase Receptor 72 3     

External Ids:    HGNC: 96181   Entrez Gene: 57542   Ensembl: ENSG000001126557   OMIM: 6018905   UniProtKB: Q133083   

Export aliases for PTK7 gene to outside databases

Previous GC identifers: GC06P043046 GC06P043090 GC06P043153 GC06P042761


Summaries
for PTK7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTK7:
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular
signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved
in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308
Function: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known
as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell
migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis,
epithelial tissue organization and angiogenesis

Gene Wiki entry for PTK7


Genomic Views
for PTK7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTK7 gene promoter:
         GR   Sox5   GATA-3   Bach2   GR-beta   RelA   GR-alpha   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1-p12.2   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1-p12.2

PTK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTK7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043044:  view genomic region     (about GC identifiers)

Start:
 43,044,006 bp from pter      End:
 43,129,457 bp from pter
Size:
 85,452 bases      Orientation:
 plus strand

Proteins
for PTK7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308 (See protein sequence)
Recommended Name: Inactive tyrosine-protein kinase 7 precursor  
Size: 1070 amino acids; 118392 Da
Subunit: Interacts with CTNNB1
Subcellular location: Membrane; Single-pass type I membrane protein. Cell junction. Note=Co-localizes with MMP14 at
cell junctions. Also localizes at the leading edge of migrating cells
Secondary accessions: A8K974 B7Z477 E9PFZ5 Q13417 Q5T650 Q6IQ54 Q8NFA5 Q8NFA6 Q8NFA7 Q8NFA8
Alternative splicing: 6 isoforms:  Q13308-1   Q13308-2   Q13308-3   Q13308-4   Q13308-5   Q13308-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PTK7: NX_Q13308

Post-translational modifications:

  • MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane
    • C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13308

    • PTK7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257327.1  NP_002812.2  NP_690619.1  NP_690620.1  NP_690621.1  

    ENSEMBL proteins: 
     ENSP00000230419   ENSP00000417607   ENSP00000420322   ENSP00000419037   ENSP00000326029  
     ENSP00000325992   ENSP00000230418   ENSP00000325462   ENSP00000418754   ENSP00000420165  
     ENSP00000420765   ENSP00000419096   ENSP00000418545   ENSP00000418462   ENSP00000420186  
     ENSP00000418386  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): PTK7
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    Novus Biologicals PTK7 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PTK7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005887integral to plasma membrane TAS7478540
    GO:0005911cell-cell junction IDA--
    GO:0016021integral to membrane ----


    PTK7 for ontologies           About GeneDecksing



    PTK7 Antibody Products: 
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    Uscn ELISAs and CLIAs for PTK7

    Protein Domains /
    Families
    for PTK7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTK7 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q13308

    ProtoNet protein and cluster: Q13308

    4 Blocks protein families:
    IPB002011 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Function
    for PTK7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308
    Function: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known
    as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell
    migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis,
    epithelial tissue organization and angiogenesis
    Induction: Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines
    established from highly metastatic invasive carcinomas (at protein level)

         Genatlas biochemistry entry for PTK7:
    protein tyrosine kinase 7,expressed in K-562,human leukemia cell and liver

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTK7
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PTK7:
    hsa-miR-205 hsa-miR-409-5p hsa-miR-3141 hsa-miR-2278 hsa-miR-503 hsa-miR-452*
    SwitchGear 3'UTR luciferase reporter plasmid: PTK7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTK7 (see all 7)
    OriGene shRNA RFP: PTK7
    OriGene siRNA: PTK7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTK7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PTK7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTK7 (see all 10)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS8882711
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    PTK7 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PTK7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased mitotic index 

    Animal Models:
         12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptk7):
     behavior/neurological  cardiovascular system  embryogenesis  growth/size  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  nervous system  renal/urinary system  respiratory system 
     skeleton  vision/eye 

    PTK7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTK7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTK7 (see all 29)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for PTK7
        Tyrosine Kinases / Adaptors



    PTK7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTK7

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for PTK7 (Q133082, 3 ENSP000002304194) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352222, 3, ENSP000003444564MINT-8114708 MINT-8114662 MINT-8114684 MINT-8114810 MINT-8114644 I2D: score=1 STRING: ENSP00000344456
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    DVL2O146413I2D: score=1 
    WNT9BO149053I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001736establishment of planar polarity IEA--
    GO:0001843neural tube closure IEA--
    GO:0003401axis elongation IEA--
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS7478540


    PTK7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTK7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTK7 for compounds           About GeneDecksing

    EMD Millipore small molecules for PTK7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTK7

    2 HMDB Compounds for PTK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    10/19 Novoseek chemical compound relationships for PTK7 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholecystokinin tetrapeptide 98.5 28 15467707 (2), 1911739 (1), 9755359 (1), 8771610 (1) (see all 27)
    tetrapeptide 92.6 57 15706463 (2), 8458396 (1), 8880078 (1), 9285937 (1) (see all 55)
    asperlicin 80.3 1 12789687 (1)
    acth 59.2 17 10840174 (3), 10664826 (2), 16817979 (2), 9335081 (1) (see all 11)
    alprazolam 44.8 2 12700707 (2)
    gaba 36.2 12 12658378 (6), 17109076 (3)
    5-hydroxytryptophan 35 2 15346539 (1), 15260907 (1)
    vigabatrin 32.7 2 11682253 (2)
    citalopram 23.3 5 16541242 (3), 9401314 (2)
    benzodiazepine 15.8 6 7838917 (3)

    Search CenterWatch for drugs/clinical trials and news about PTK7 

    Transcripts
    for PTK7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTK7 gene (6 alternative transcripts): 
    NM_001270398.1  NM_002821.4  NM_152880.3  NM_152881.3  NM_152882.3  NM_152883.1  

    Unigene Cluster for PTK7:

    PTK7 protein tyrosine kinase 7
    Hs.90572  [show with all ESTs]
    Unigene Representative Sequence: NM_002821
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000230419(uc003oub.1 uc003ouc.1 uc003oud.1 uc003oue.1 uc003ouf.1 uc003oug.1 uc011dve.1)
    ENST00000476760 ENST00000470019(uc010jyj.1) ENST00000471863(uc003oua.3)
    ENST00000352931 ENST00000345201 ENST00000230418 ENST00000349241 ENST00000487673
    ENST00000481273 ENST00000481946 ENST00000490710 ENST00000489707 ENST00000470471
    ENST00000493339 ENST00000494146 ENST00000461100 ENST00000497957

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF531868.1 AF531869.1 AF531870.1 AF531871.1 AF531872.1 AK055648.1 AK124108.1 AK291016.1 
    AK292589.1 AK296931.1 AK296953.1 AL157486.1 BC002377.2 BC014626.2 BC046109.2 BC071557.1 
    NR_072997.1 NR_072998.1 U33635.1 U40271.2 

    21 DOTS entries:

    DT.95315961  DT.100028547  DT.92454201  DT.100028554  DT.100788727  DT.102833039  DT.99930053  DT.95286308 
    DT.100028548  DT.100788728  DT.100804885  DT.70102513  DT.100028549  DT.95291408  DT.95291444  DT.100753629 
    DT.121376098  DT.316354  DT.80100210  DT.92454195  DT.95291438 

    24/253 AceView cDNA sequences (see all 253):

    NM_152883 BC071557 BM970585 AI589821 AK131487 AK055648 BU682156 AI589807 
    BC002377 CA389442 AI656361 AW204568 AF531870 AU125657 AW297907 AI471986 
    AI371770 BM801688 AL157486 AA634328 BM970687 BQ478270 BQ028740 AI648506 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for PTK7 (see all 19)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
    SP1:        -                                         -                       -     -                                                                       -   
    SP2:        -                 -     -                 -                       -     -                                                                       -   
    SP3:        -                                         -                       -     -                                                           -     -     -   
    SP4:        -                                         -                       -     -                                                                       -   
    SP5:        -                                         -                       -     -                                   -     -                             -   

    ExUns: 16a · 16b · 16c · 16d ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
    SP1:  -     -     -           -     -                 -                       -                                       
    SP2:  -     -     -           -     -                 -                       -                                       
    SP3:  -     -     -           -     -                 -                       -                                       
    SP4:  -     -     -           -     -                 -     -     -     -     -                                       
    SP5:  -     -     -           -     -                 -                       -                                       


    ECgene alternative splicing isoforms for PTK7

    Expression
    for PTK7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGTAGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTK7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTK7

    SOURCE GeneReport for Unigene cluster: Hs.90572

    UniProtKB/Swiss-Prot: PTK7_HUMAN, Q13308
    Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in
    thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in
    colon

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    Orthologs
    for PTK7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTK7 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PTK71 PTK7 protein tyrosine kinase 7 73.49(n)
    72.82(a)    		   421257  NM_001031035.1  NP_001026206.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PTK76
    		 --
    		 69(a)
    		 1 ↔ 1
    		 2(143969579-143997812)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC060500.12   -- 76.41(n)    BC060500.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1122116
    		 zgc:112211
    		 60(a)
    		 1 ↔ 1
    		 22(41304083-41369035)
    fruit fly
    (Drosophila melanogaster)    		 Insecta otk1 , 3 axon guidance cell adhesion receptor3
    off-track1    		 44(a)
    (best of 2)3
    52.37(n)1
    39.9(a)1    		   362831  NM_078981.21  NP_523705.21 


    ENSEMBL Gene Tree for PTK7 (if available)
    TreeFam Gene Tree for PTK7 (if available) 

    Paralogs
    for PTK7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTK7 gene
    VCAM12  IGSF102  HMCN12  ENSG000002154282  HMCN22  MXRA52  HSPG22  
    18/41 SIMAP similar genes for PTK7 using alignment to 10 protein entries:     PTK7_HUMAN (see all proteins) (see all similar genes):
    DKFZp434L0319    MET    EZR-ROS1    AURKC    NTRK1    ABL1
    BRAF    FGR    LTK    MUSK    EML4-ALK    PPFIBP1-ALK
    BTK kinase deficient isoform 2    DDR1    EPHA2    RYK    tec    ALK

    PTK7 for paralogs           About GeneDecksing



    Genomic Variants
    for PTK7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1500 NCBI SNPs in PTK7 are shown (see all 1500)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1472444121,2
    		--43042018(+) GCAGCC/TGCCTT 9 -- int1 us2k10--------
    rs1141946781,2
    		F,--43042143(+) ATTCAT/CGTGGT 9 -- int1 us2k11Minor allele frequency- C:0.03NA 120
    rs2011948231,2
    		--43042344(+) GGGTAA/GTGTTG 9 -- us2k1 int10--------
    rs2017483281,2
    		--43042420(+) CAACCC/TGGCCC 9 -- ut31 us2k10--------
    rs1828437421,2
    		--43042485(+) CCTGGA/CTCTTC 9 -- us2k1 ut310--------
    rs1865542191,2
    		--43042500(+) CCCCTA/CGGTGG 9 -- ut31 us2k10--------
    rs1407537021,2
    		--43042752(+) CTGGCC/TGCTCT 10 -- ut31 us2k10--------
    rs1452872271,2
    		--43042812(+) TTAAAC/TAAAAG 10 -- us2k1 ut310--------
    rs1914278041,2
    		--43042823(+) AATCAA/GGTAAC 10 -- us2k1 ut310--------
    rs1147411031,2
    		F,--43043303(+) TCCTCC/GTGACC 10 -- us2k1 ds50011Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for PTK7 (43044006 - 43129457 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PTK7: --
    Human Gene Mutation Database (HGMD): PTK7

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PTK7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTK7 for disorders           About GeneDecksing

    OMIM gene information: 601890    OMIM disorders: --

    20/23 diseases for PTK7 (see all 23):    About MalaCards
    colon carcinoma    obsessive-compulsive disorder    social phobia    agoraphobia
    anxiety disorder    panic disorder    phobia    irritable bowel syndrome
    carcinoma    acute myeloid leukemia    myeloid leukemia    hypothyroidism
    colon cancer    schizophrenia    blindness    colorectal cancer
    leukemia    melanoma    thyroiditis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for PTK7:
    Panic disorder     Agoraphobia

    10 Novoseek disease relationships for PTK7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    panic 91.9 90 15467707 (5), 18534623 (3), 16817979 (3), 17035932 (3) (see all 45)
    panic attacks 91.5 47 9085405 (4), 11668667 (4), 10693152 (2), 19289240 (2) (see all 34)
    panic disorder 86.7 45 1467375 (3), 18534623 (2), 7855203 (2), 10693152 (2) (see all 34)
    premenstrual dysphoric disorder 47.5 5 9885787 (2), 11457531 (1)
    effects cardiovascular 34.5 4 7838917 (1), 8886299 (1), 10082241 (1)
    agoraphobia 30.7 1 8771610 (1)
    anxiety disorders 30.1 1 2180549 (1)
    colon carcinoma 20.7 5 7478540 (2), 17173930 (1), 15683231 (1)
    psychiatric disorder 0 1 10631762 (1)
    schizophrenia 0 1 11803530 (1)


    Export disorders for PTK7 gene to outside databases

    Publications
    for PTK7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTK7 gene, integrated from 9 sources (see all 161):
    (articles sorted by number of sources associating them with PTK7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. (PubMed id 7478540)1, 2, 3, 9 Mossie K.... Ullrich A. (1995)
    2. Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA. (PubMed id 12427550)1, 2, 9 Jung J.W....Lee S.T. (2002)
    3. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. (PubMed id 8882711)1, 2, 9 Park S.-K.... Lee S.-T. (1996)
    4. Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling. (PubMed id 21132015)1, 2 Puppo F.... Borg J.-P. (2011)
    5. Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway. (PubMed id 21103379)1, 2 Meng L.... Tan W. (2010)
    6. The cell polarity PTK7 receptor acts as a modulator o f the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome. (PubMed id 20558616)1, 2 Prebet T....Borg J.P. (2010)
    7. The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. (PubMed id 20837484)1, 2 Golubkov V.S.... Strongin A.Y. (2010)
    8. Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. (PubMed id 18471990)1, 2 Shin W.S....Lee S.T. (2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)

    External Searches for PTK7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTK7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5754 HGNC: 9618 AceView: PTK7 Ensembl:ENSG00000112655 euGenes: HUgn5754
    ECgene: PTK7 H-InvDB: PTK7

    Other Databases showing PTK7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTK7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTK7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTK7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTK7 gene:
    Search GeneIP for patents involving PTK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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