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Aliases for PTK7 Gene

Aliases for PTK7 Gene

  • Protein Tyrosine Kinase 7 (Inactive) 2 3 5
  • Colon Carcinoma Kinase 4 2 3 4
  • Pseudo Tyrosine Kinase Receptor 7 3 4
  • PTK7 Protein Tyrosine Kinase 7 2 3
  • Tyrosine-Protein Kinase-Like 7 3 4
  • CCK-4 3 4
  • CCK4 3 4
  • Inactive Tyrosine-Protein Kinase 7 3
  • Protein Tyrosine Kinase 7 2
  • Protein-Tyrosine Kinase 7 4

External Ids for PTK7 Gene

Previous GeneCards Identifiers for PTK7 Gene

  • GC06P043046
  • GC06P043090
  • GC06P043153
  • GC06P042761

Summaries for PTK7 Gene

Entrez Gene Summary for PTK7 Gene

  • This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PTK7 Gene

PTK7 (Protein Tyrosine Kinase 7 (Inactive)) is a Protein Coding gene. Diseases associated with PTK7 include Panic Disorder and Agoraphobia. Among its related pathways are GPCR Pathway and Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LMTK2.

UniProtKB/Swiss-Prot for PTK7 Gene

  • Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Gene Wiki entry for PTK7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTK7 Gene

Genomics for PTK7 Gene

Regulatory Elements for PTK7 Gene

Enhancers for PTK7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G043119 1.6 Ensembl ENCODE dbSUPER 11.9 +47.1 47122 8.7 FOXA2 PKNOX1 MLX ZFP64 ARID4B DMAP1 FEZF1 FOS ZNF263 SP3 CUL7 ENSG00000271970 BICRAL POLH RPL24P4 RPL34P14 RPS2P29 PEX6 PTK7 KLC4
GH06G043011 1.2 ENCODE 11.1 -61.4 -61445 7.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 CUL7 MEA1 KLC4 RN7SL403P PTK7 RPL7L1 DNPH1 PEX6 KLHDC3
GH06G043129 1 ENCODE dbSUPER 11.9 +52.9 52910 0.2 HDGF PKNOX1 RB1 SIN3A ZNF335 ZNF316 CTBP1 POLR2A SCRT2 FOS PTK7 KLC4 CUL7 RN7SL403P PPP2R5D ENSG00000231113 CNPY3 MEA1 KLHDC3 RPL7L1
GH06G043113 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +39.2 39151 4.7 HDGF PKNOX1 CREB3L1 ARNT FEZF1 ZNF2 ZNF766 KLF13 ZNF592 MEF2D CUL7 DNPH1 PEX6 PTK7 PIR51341 SRF
GH06G043103 0.5 ENCODE dbSUPER 12.6 +27.4 27395 0.9 CUL7 PTK7 KLC4 RN7SL403P PIR51341 SRF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTK7 on UCSC Golden Path with GeneCards custom track

Promoters for PTK7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197083 432 1401 PKNOX1 AGO1 ZFP64 SIN3A DMAP1 ZNF121 SLC30A9 GLIS2 KLF7 SP3

Genomic Location for PTK7 Gene

Chromosome:
6
Start:
43,076,268 bp from pter
End:
43,161,720 bp from pter
Size:
85,453 bases
Orientation:
Plus strand

Genomic View for PTK7 Gene

Genes around PTK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTK7 Gene

Proteins for PTK7 Gene

  • Protein details for PTK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13308-PTK7_HUMAN
    Recommended name:
    Inactive tyrosine-protein kinase 7
    Protein Accession:
    Q13308
    Secondary Accessions:
    • A8K974
    • B7Z477
    • E9PFZ5
    • Q13417
    • Q5T650
    • Q6IQ54
    • Q8NFA5
    • Q8NFA6
    • Q8NFA7
    • Q8NFA8

    Protein attributes for PTK7 Gene

    Size:
    1070 amino acids
    Molecular mass:
    118392 Da
    Quaternary structure:
    • Interacts with CTNNB1.

    Alternative splice isoforms for PTK7 Gene

neXtProt entry for PTK7 Gene

Post-translational modifications for PTK7 Gene

  • MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
  • Glycosylation at Asn116, isoforms=2, 3, 4, 5, 6175, isoforms=2, 3, 4, 5, 6184, isoforms=2, 3, 4, 5, 6214, isoforms=2, 3, 4, 5, 6268, isoforms=2, 3, 4, 5, 6283, Asn405, Asn463, Asn567, and Asn646
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PTK7 (CCK4)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PTK7

No data available for DME Specific Peptides for PTK7 Gene

Domains & Families for PTK7 Gene

Suggested Antigen Peptide Sequences for PTK7 Gene

Graphical View of Domain Structure for InterPro Entry

Q13308

UniProtKB/Swiss-Prot:

PTK7_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with PTK7: view

Function for PTK7 Gene

Molecular function for PTK7 Gene

GENATLAS Biochemistry:
protein tyrosine kinase 7,expressed in K-562,human leukemia cell and liver
UniProtKB/Swiss-Prot Function:
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
UniProtKB/Swiss-Prot Induction:
Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines established from highly metastatic invasive carcinomas (at protein level).

Gene Ontology (GO) - Molecular Function for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 21132015
GO:0005524 ATP binding IEA --
GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway NAS,IEA 24431302
genes like me logo Genes that share ontologies with PTK7: view
genes like me logo Genes that share phenotypes with PTK7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTK7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTK7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTK7 Gene

Localization for PTK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTK7 Gene

Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTK7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0005911 cell-cell junction IDA 20837484
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTK7: view

Pathways & Interactions for PTK7 Gene

genes like me logo Genes that share pathways with PTK7: view

SIGNOR curated interactions for PTK7 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001736 establishment of planar polarity IEA --
GO:0001843 neural tube closure IEA --
GO:0003281 ventricular septum development IEA --
GO:0003401 axis elongation IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PTK7: view

Drugs & Compounds for PTK7 Gene

(14) Drugs for PTK7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(7) Additional Compounds for PTK7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PTK7: view

Transcripts for PTK7 Gene

Unigene Clusters for PTK7 Gene

Protein tyrosine kinase 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTK7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTK7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10:
SP11: - - - - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 16a · 16b · 16c · 16d ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8:
SP9: - - - - -
SP10: - -
SP11: - - - - -
SP12:
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - - -
SP16: -
SP17:
SP18:
SP19: - -

Relevant External Links for PTK7 Gene

GeneLoc Exon Structure for
PTK7
ECgene alternative splicing isoforms for
PTK7

Expression for PTK7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTK7 Gene

mRNA differential expression in normal tissues according to GTEx for PTK7 Gene

This gene is overexpressed in Uterus (x5.4) and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for PTK7 Gene

This gene is overexpressed in Uterus (18.2), Fetal ovary (9.0), and Ovary (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTK7 Gene



NURSA nuclear receptor signaling pathways regulating expression of PTK7 Gene:

PTK7

SOURCE GeneReport for Unigene cluster for PTK7 Gene:

Hs.90572

mRNA Expression by UniProt/SwissProt for PTK7 Gene:

Q13308-PTK7_HUMAN
Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

Evidence on tissue expression from TISSUES for PTK7 Gene

  • Liver(4.2)
  • Nervous system(3.5)
  • Gall bladder(2.2)
  • Heart(2.2)
  • Pancreas(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with PTK7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTK7 Gene

Orthologs for PTK7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTK7 34 35
  • 98.97 (n)
cow
(Bos Taurus)
Mammalia PTK7 34 35
  • 89.51 (n)
dog
(Canis familiaris)
Mammalia PTK7 34 35
  • 89.48 (n)
mouse
(Mus musculus)
Mammalia Ptk7 34 16 35
  • 87.79 (n)
oppossum
(Monodelphis domestica)
Mammalia PTK7 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTK7 34 35
  • 69.3 (n)
lizard
(Anolis carolinensis)
Reptilia PTK7 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487595 34
  • 70.31 (n)
zebrafish
(Danio rerio)
Actinopterygii ptk7b 34
  • 62.28 (n)
ptk7a 35
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011489 34
  • 49.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta otk 36 34 35
  • 47.45 (n)
CG8964 36 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for PTK7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTK7 Gene

ENSEMBL:
Gene Tree for PTK7 (if available)
TreeFam:
Gene Tree for PTK7 (if available)

Paralogs for PTK7 Gene

Paralogs for PTK7 Gene

genes like me logo Genes that share paralogs with PTK7: view

Variants for PTK7 Gene

Sequence variations from dbSNP and Humsavar for PTK7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_041508 A colorectal adenocarcinoma sample
rs1000016969 -- 43,114,906(+) GCATG(G/T)TGGCA intron-variant
rs1000026213 -- 43,116,936(+) CTCGT(C/G)CTTCA intron-variant
rs1000078234 -- 43,146,834(+) TTATC(A/G)CGGTA intron-variant
rs1000088647 -- 43,115,248(+) AGGAA(C/G)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTK7 Gene

Variant ID Type Subtype PubMed ID
dgv10640n54 CNV loss 21841781
esv3571027 CNV loss 25503493
nsv1017398 CNV gain 25217958
nsv437509 CNV loss 16327808
nsv462927 CNV loss 19166990
nsv462930 CNV loss 19166990
nsv462932 CNV loss 19166990
nsv521730 CNV loss 19592680
nsv602992 CNV loss 21841781
nsv602996 CNV loss 21841781
nsv950169 CNV deletion 24416366

Variation tolerance for PTK7 Gene

Residual Variation Intolerance Score: 4.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTK7 Gene

Human Gene Mutation Database (HGMD)
PTK7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTK7 Gene

Disorders for PTK7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PTK7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
panic disorder
  • panic anxiety syndrome
agoraphobia
  • fear of open spaces
social phobia
  • phobia social
phobic disorder
  • phobic anxiety disorder
cataract 14, multiple types
  • cataract 14 multiple types
- elite association - COSMIC cancer census association via MalaCards
Search PTK7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTK7

Genetic Association Database (GAD)
PTK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTK7
genes like me logo Genes that share disorders with PTK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTK7 Gene

Publications for PTK7 Gene

  1. Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. (PMID: 7478540) Mossie K. … Ullrich A. (Oncogene 1995) 2 3 4 22 64
  2. Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA. (PMID: 12427550) Jung J.-W. … Lee S.-T. (Biochim. Biophys. Acta 2002) 3 4 22 64
  3. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. (PMID: 8882711) Park S.-K. … Lee S.-T. (J. Biochem. 1996) 3 4 22 64
  4. Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling. (PMID: 21132015) Puppo F. … Borg J.-P. (EMBO Rep. 2011) 3 4 64
  5. The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome. (PMID: 20558616) Prebet T. … Borg J.-P. (Blood 2010) 3 4 64

Products for PTK7 Gene

Sources for PTK7 Gene

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