Aliases for PTK6 Gene
Aliases for PTK6 Gene
External Ids for PTK6 Gene
- HGNC: 9617
- Entrez Gene: 5753
- Ensembl: ENSG00000101213
- OMIM: 602004
- UniProtKB: Q13882
Previous GeneCards Identifiers for PTK6 Gene
- GC20M062037
- GC20M061997
- GC20M062839
- GC20M062886
- GC20M061630
- GC20M062159
- GC20M058889
Summaries for PTK6 Gene
-
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for PTK6 Gene
PTK6 (Protein Tyrosine Kinase 6) is a Protein Coding gene. Diseases associated with PTK6 include Dysgraphia and Corneal Dystrophy, Band-Shaped. Among its related pathways are Signaling by PTK6 and Signaling by ERBB2. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is SRMS.
UniProtKB/Swiss-Prot for PTK6 Gene
-
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.
-
Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTK6 Gene
Genomics for PTK6 Gene
GeneHancer (GH) Regulatory Elements for PTK6 Gene
Promoters and enhancers for PTK6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PTK6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PTK6 gene promoter:
Regulatory Element Products
Genomic Locations for PTK6 Gene
Genomic Locations for PTK6 Gene
- chr20:63,528,001-63,537,370
- (GRCh38/hg38)
- Size:
- 9,370 bases
- Orientation:
- Minus strand
- chr20:62,159,766-62,168,723
- (GRCh37/hg19)
Genomic View for PTK6 Gene
Genes around PTK6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.33 by Ensembl
- 20q13.33 by Entrez Gene
- 20q13.33 by HGNC
PTK6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTK6 Gene
Proteins for PTK6 Gene
-
Protein details for PTK6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13882-PTK6_HUMAN
- Recommended name:
- Protein-tyrosine kinase 6
- Protein Accession:
- Q13882
- B2RCR3
- B4DW46
- Q58F01
Protein attributes for PTK6 Gene
- Size:
- 451 amino acids
- Molecular mass:
- 51834 Da
- Quaternary structure:
-
- Interacts with GAP-A.p65 (By similarity). Interacts (via SH3 and SH2 domains) with KHDRBS1. Interacts (via SH3 and SH2 domains) with phosphorylated IRS4. Interacts with ADAM15. Interacts (via SH3 domain) with SFPQ. Interacts with EGFR and ERBB2. Interacts with STAP2. Interacts with PNX. Interacts with SFPQ. Interacts with PTK/ATK. Interacts with CTNNB1.
- Miscellaneous:
-
- The inhibitors bind to the ATP-binding pocket.
- SequenceCaution:
-
- Sequence=BAG62908.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PTK6 Gene
Protein Expression for PTK6 Gene
Selected DME Specific Peptides for PTK6 Gene
- Q13882:
-
- RDLAARN
- KWTAPEA
- KSDVWSFG
Post-translational modifications for PTK6 Gene
- Autophosphorylated. Autophosphorylation of Tyr-342 leads to an increase of kinase activity. Tyr-447 binds to the SH2 domain when phosphorylated and negatively regulates kinase activity.
Other Protein References for PTK6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PTK6 (Brk)
- Cell Signaling Technology (CST) Antibodies for PTK6 (Brk)
-
Custom Antibody ServicesOriGene Antibodies for PTK6
- Novus Biologicals Antibodies for PTK6
-
Abcam antibodies for PTK6
-
Cloud-Clone Corp. Antibodies for PTK6
- Invitrogen Antibodies for PTK6
- GeneTex PTK6 antibody for PTK6
- Sino Biological Antibodies for PTK6
Protein Products
-
OriGene Purified Proteins for PTK6
- Search Origene for MassSpec and Protein Over-expression Lysates for PTK6
- Origene Custom Protein Services for PTK6
- Sino Biological Cell Lysates for PTK6
- Sino Biological Recombinant Proteins for PTK6
-
Cloud-Clone Corp. Proteins for PTK6
- GeneTex Proteins for PTK6
-
Abcam proteins for PTK6
Assay Products
-
Cloud-Clone Corp. Assay Kits for PTK6
- antibodies-online: Search results for 11 available PTK6 Elisa Kits ranked by validation data
- Compare Top PTK6 Elisa Kits
-
Quality Products:
Domains & Families for PTK6 Gene
Gene Families for PTK6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for PTK6 Gene
Suggested Antigen Peptide Sequences for PTK6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13882UniProtKB/Swiss-Prot:
PTK6_HUMAN :- The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.
- Domain:
-
- The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.
Function for PTK6 Gene
Molecular function for PTK6 Gene
- GENATLAS Biochemistry:
- protein tyrosine kinase 6,non receptor type,expressed in K-562,human leukemia cell and liver
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=83 uM for ATP {ECO:0000269 PubMed:12121988}; Vmax=37 nmol/min/mg enzyme {ECO:0000269 PubMed:12121988};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by EGF, NRG1 and IGF1. Inhibited by SOCS3 to phosphorylate STAT3. Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region. Interaction between Trp-184 within SH2-TK linker region and the catalytic domain appears essential for positive regulation of kinase activity.
- UniProtKB/Swiss-Prot Function:
- Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.
- UniProtKB/Swiss-Prot Function:
- Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.
Enzyme Numbers (IUBMB) for PTK6 Gene
Phenotypes From GWAS Catalog for PTK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IDA,TAS | 10913193 |
| GO:0005102 | receptor binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 10913193 |
Phenotypes for PTK6 Gene
- MGI mutant phenotypes for PTK6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTK6:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased IL-8 secretion
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased simian virus 40 (SV40) infection
- Decreased viability in HMC1.1 cells
Animal Models for PTK6 Gene
- MGI Knock Outs for PTK6:
-
- Ptk6 tm1Aty
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PTK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
- Search ViGene Biosciences for PTK6
CRISPR Products
-
OriGene CRISPR knockouts for PTK6
- genomics-online: gRNA clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
- Applied Biological Materials CRISPR for PTK6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTK6
- GenScript: Design CRISPR guide RNA sequences for PTK6
miRNA for PTK6 Gene
- miRTarBase miRNAs that target PTK6
-
- hsa-mir-5587-5p (MIRT542511)
- hsa-mir-6736-5p (MIRT542512)
- hsa-mir-4701-3p (MIRT542513)
- hsa-mir-1262 (MIRT542514)
- hsa-mir-6720-5p (MIRT542515)
- hsa-mir-6512-3p (MIRT542516)
- hsa-mir-542-3p (MIRT542517)
- hsa-mir-4252 (MIRT542518)
- hsa-mir-661 (MIRT542519)
- hsa-mir-6776-5p (MIRT542520)
- hsa-mir-191-3p (MIRT542521)
- hsa-mir-766-3p (MIRT542522)
- hsa-mir-6742-3p (MIRT542523)
- hsa-mir-6849-3p (MIRT542524)
- hsa-mir-1273g-3p (MIRT542525)
- hsa-mir-548s (MIRT665143)
- hsa-mir-4470 (MIRT665144)
- hsa-mir-3926 (MIRT665145)
- hsa-mir-3675-3p (MIRT665146)
- hsa-mir-454-5p (MIRT665147)
- hsa-mir-942-3p (MIRT665148)
- hsa-mir-652-5p (MIRT665149)
- hsa-mir-548as-3p (MIRT665150)
- hsa-mir-6086 (MIRT686071)
- hsa-mir-2467-3p (MIRT686072)
- hsa-mir-377-5p (MIRT686073)
- hsa-mir-1827 (MIRT686074)
- hsa-mir-4257 (MIRT686075)
- hsa-mir-4740-3p (MIRT686076)
- hsa-mir-3614-5p (MIRT686077)
- hsa-mir-6500-3p (MIRT686078)
- hsa-mir-6511a-5p (MIRT686079)
- hsa-mir-1910-3p (MIRT686080)
- hsa-mir-377-3p (MIRT724959)
- hsa-mir-4532 (MIRT724960)
- hsa-mir-1247-3p (MIRT724961)
- hsa-mir-622 (MIRT724962)
- hsa-mir-1306-5p (MIRT724963)
- hsa-mir-1228-3p (MIRT724964)
- hsa-mir-1273h-5p (MIRT762068)
- hsa-mir-149-3p (MIRT762813)
- hsa-mir-30b-3p (MIRT764606)
- hsa-mir-30c-1-3p (MIRT764668)
- hsa-mir-30c-2-3p (MIRT764713)
- hsa-mir-34b-3p (MIRT765791)
- hsa-mir-3689a-3p (MIRT766834)
- hsa-mir-3689b-3p (MIRT766922)
- hsa-mir-3689c (MIRT767010)
- hsa-mir-3929 (MIRT767794)
- hsa-mir-4419b (MIRT768790)
- hsa-mir-4478 (MIRT769541)
- hsa-mir-455-3p (MIRT770401)
- hsa-mir-4649-3p (MIRT770657)
- hsa-mir-4722-5p (MIRT771576)
- hsa-mir-4728-5p (MIRT771729)
- hsa-mir-485-5p (MIRT772635)
- hsa-mir-6499-3p (MIRT776344)
- hsa-mir-6516-5p (MIRT777195)
- hsa-mir-665 (MIRT777597)
- hsa-mir-6779-5p (MIRT778912)
- hsa-mir-6780a-5p (MIRT779002)
- hsa-mir-6785-5p (MIRT779139)
- hsa-mir-6788-5p (MIRT779245)
- hsa-mir-6799-5p (MIRT779438)
- hsa-mir-6807-5p (MIRT779603)
- hsa-mir-6808-5p (MIRT779695)
- hsa-mir-6883-5p (MIRT780935)
- hsa-mir-6884-5p (MIRT781023)
- hsa-mir-6893-5p (MIRT781228)
- hsa-mir-7106-5p (MIRT781370)
- hsa-mir-7160-5p (MIRT781627)
- hsa-mir-940 (MIRT782922)
miRNA Products
- Search ViGene Biosciences for PTK6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PTK6
- Browse OriGene Inhibitory RNA Products For PTK6
- genomics-online: shRNA clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
Clone Products
- Sino Biological Human cDNA Clone for PTK6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTK6
- Applied Biological Materials Clones for PTK6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PTK6
-
ViGene Biosciences adenoviral particle packaged cDNA for PTK6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTK6 Gene
Localization for PTK6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTK6 Gene
- Cytoplasm. Nucleus. Cell projection, ruffle. Membrane. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Plasma membrane (3)
- Nuclear bodies (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IEA,IDA | 15572663 |
| GO:0005634 | nucleus | IDA,IEA | 10913193 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 15572663 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PTK6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by PTK6 |
.01
|
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | Signaling by ERBB2 | ||
| 5 | Mitotic G1-G1/S phases |
.83
|
|
Pathways by source for PTK6 Gene
1 Cell Signaling Technology pathway for PTK6 Gene
2 BioSystems pathways for PTK6 Gene
20 Reactome pathways for PTK6 Gene
1 Qiagen pathway for PTK6 Gene
Interacting Proteins for PTK6 Gene
Selected Interacting proteins:
ENSP00000217185
Q13882-PTK6_HUMAN
for PTK6 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for PTK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | TAS | 8036022 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | -- |
| GO:0007260 | tyrosine phosphorylation of STAT protein | IDA | 16568091 |
| GO:0009968 | negative regulation of signal transduction | TAS | -- |
| GO:0010976 | positive regulation of neuron projection development | IMP | 17910947 |
Drugs & Compounds for PTK6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vandetanib | Approved April 2011 | Pharma | Target, inhibitor | VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| ATP | Investigational | Nutra | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for PTK6 Gene
mRNA/cDNA for PTK6 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (53) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTK6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PTK6
- genomics-online: gRNA clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
- Applied Biological Materials CRISPR for PTK6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTK6
- GenScript: Design CRISPR guide RNA sequences for PTK6
miRNA Products
- Search ViGene Biosciences for PTK6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PTK6
- Browse OriGene Inhibitory RNA Products For PTK6
- genomics-online: shRNA clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
Clone Products
- Sino Biological Human cDNA Clone for PTK6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTK6
- Applied Biological Materials Clones for PTK6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for PTK6 Gene
mRNA differential expression in normal tissues according to GTEx for PTK6 Gene
This gene is overexpressed in Esophagus - Mucosa (x14.2), Skin - Sun Exposed (Lower leg) (x6.4), Skin - Not Sun Exposed (Suprapubic) (x6.2), Colon - Transverse (x5.4), and Vagina (x4.9).
This gene is overexpressed in Cervix (64.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTK6 Gene
NURSA nuclear receptor signaling pathways regulating expression of PTK6 Gene:
PTK6SOURCE GeneReport for Unigene cluster for PTK6 Gene:
Hs.51133mRNA Expression by UniProt/SwissProt for PTK6 Gene:
Q13882-PTK6_HUMAN
Tissue specificity:
Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines.
Evidence on tissue expression from TISSUES for PTK6 Gene
- Skin(4.4)
- Blood(4.3)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for PTK6
-
OriGene qPCR primer pairs and template standards for PTK6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTK6 Gene
Orthologs for PTK6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTK6 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PTK6 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ptk6 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ptk6 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PTK6 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTK6 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PTK6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptk6 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptk6b 33 34 |
|
||
| ptk6a 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F09A5.2 35 |
|
|
|
| F57B9.8 35 |
|
|
- Species where no ortholog for PTK6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PTK6 Gene
(60) SIMAP similar genes for PTK6 Gene using alignment to 1 proteins:
- HCK
- FYN
- FRK
- EPHA2
- YES1
- SRC
- LYN
- IGF1R
- EPHA6
- GRB2
- FGR
- SRMS
- INSR
- EPHA4
- BLK
- BCR/ABL fusion
- LCK
- FER
- EPHA3
- BTK kinase deficient isoform 2
- BMX
- ABL2
- PTK2
- EPHB3
- EPHB2
- TEC
- TXK
- EPHB2 variant protein
- EPHA5
- DKFZp666O0110
- MATK
- BTK
- lsk
- TPM3-ROS1
- SLC34A2/ROS1 fusion
- SLC34A2/ROS fusion
- SLC34A2-ROS1
- SDC4-ROS1_S4
- R34
- SDC4-ROS1_S4
- R32
- SDC4-ROS1_S2
- R32
- ROS1
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- EZR-ROS1
- EPHB1
- CD74/ROS fusion
- CD74-ROS1_C6
- R32
- TNK2
- FGFR4
- FES
- CSK
- ITK
- FGFR2
- urf-ret
- FGFR3
- FGFR1
Variants for PTK6 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042747 | -- | 63,532,921(-) | T/A | intron_variant | |
| rs1000096831 | -- | 63,537,526(-) | G/A | upstream_transcript_variant | |
| rs1000142632 | -- | 63,531,825(-) | C/A/G | intron_variant | |
| rs1000689972 | -- | 63,535,667(-) | G/A | intron_variant | |
| rs1000956363 | -- | 63,536,336(-) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv521n27 | CNV | loss | 19166990 |
| dgv522n27 | CNV | loss | 19166990 |
| dgv7667n54 | CNV | loss | 21841781 |
| esv2758806 | CNV | gain+loss | 17122850 |
| nsv1118925 | CNV | deletion | 24896259 |
| nsv470563 | CNV | loss | 18288195 |
| nsv521734 | CNV | loss | 19592680 |
| nsv586569 | CNV | loss | 21841781 |
| nsv586571 | CNV | loss | 21841781 |
| nsv586573 | CNV | loss | 21841781 |
| nsv834033 | CNV | gain | 17160897 |
| nsv834034 | CNV | loss | 17160897 |
| nsv953306 | CNV | deletion | 24416366 |
| nsv9825 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.01;
37.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTK6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTK6 Gene
Disorders for PTK6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dysgraphia |
|
|
| corneal dystrophy, band-shaped |
|
|
| breast cancer |
|
Search PTK6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTK6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTK6 Gene
Publications for PTK6 Gene
- BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. (PMID: 19439179) Lukong KE … Richard S (Cellular signalling 2009) 3 4 22 58
- Brk is coamplified with ErbB2 to promote proliferation in breast cancer. (PMID: 18719096) Xiang B … Muthuswamy SK (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 22 58
- Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. (PMID: 18829532) Shen CH … Chen RH (Cancer research 2008) 3 4 22 58
- Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PMID: 17997837) Weaver AM … Silva CM (Breast cancer research : BCR 2007) 3 4 22 58
- Identification of STAT3 as a specific substrate of breast tumor kinase. (PMID: 16568091) Liu L … Reich NC (Oncogene 2006) 3 4 22 58
Products for PTK6 Gene
- R&D Systems Antibodies for PTK6 (Brk)
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- Custom Antibody ServicesOriGene Antibodies for PTK6
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- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for PTK6
- Cell Signaling Technology (CST) Antibodies for PTK6 (Brk)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for PTK6
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
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- Novus Biologicals proteins and lysates for PTK6
- Novus Biologicals
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- Abcam antibodies for PTK6
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- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- Cloud-Clone Corp. Antibodies for PTK6
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PTK6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTK6
- antibodies-online: Search results for 157 available PTK6 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 15 available PTK6 Proteins ranked by validation data
- Compare Top PTK6 Proteins
- GeneTex PTK6 antibody for PTK6
- GeneTex Proteins for PTK6
- ViGene Biosciences adenoviral particle packaged cDNA for PTK6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PTK6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
- Search ViGene Biosciences for PTK6
- Search Santa Cruz Biotechnology (SCBT) for PTK6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTK6
- Horizon Cell Lines for PTK6
- genomics-online: cdna clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
- orf clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
- genomics-online: gRNA clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
- genomics-online: primer clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
- genomics-online: shRNA clones - Search results for 111 available PTK6 gene related products
- Overview of 111 available PTK6 gene related products
Sources for PTK6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew