Aliases for PTK6 Gene
Aliases for PTK6 Gene
External Ids for PTK6 Gene
- HGNC: 9617
- Entrez Gene: 5753
- Ensembl: ENSG00000101213
- OMIM: 602004
- UniProtKB: Q13882
Previous GeneCards Identifiers for PTK6 Gene
- GC20M062037
- GC20M061997
- GC20M062839
- GC20M062886
- GC20M061630
- GC20M062159
- GC20M058889
Summaries for PTK6 Gene
-
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for PTK6 Gene
PTK6 (Protein Tyrosine Kinase 6) is a Protein Coding gene. Diseases associated with PTK6 include Dysgraphia and Breast Cancer. Among its related pathways are Signaling by PTK6 and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is SRMS.
UniProtKB/Swiss-Prot for PTK6 Gene
-
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.
-
Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTK6 Gene
Genomics for PTK6 Gene
Regulatory Elements for PTK6 Gene
Enhancers for PTK6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PTK6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PTK6 gene promoter:
Regulatory Element Products
Genomic Location for PTK6 Gene
- Chromosome:
- 20
- Start:
- 63,528,001 bp from pter
- End:
- 63,537,370 bp from pter
- Size:
- 9,370 bases
- Orientation:
- Minus strand
Genomic View for PTK6 Gene
Genes around PTK6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.33 by Ensembl
- 20q13.33 by Entrez Gene
- 20q13.33 by HGNC
PTK6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTK6 Gene
Proteins for PTK6 Gene
-
Protein details for PTK6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13882-PTK6_HUMAN
- Recommended name:
- Protein-tyrosine kinase 6
- Protein Accession:
- Q13882
- B2RCR3
- B4DW46
- Q58F01
Protein attributes for PTK6 Gene
- Size:
- 451 amino acids
- Molecular mass:
- 51834 Da
- Quaternary structure:
-
- Interacts with GAP-A.p65 (By similarity). Interacts (via SH3 and SH2 domains) with KHDRBS1. Interacts (via SH3 and SH2 domains) with phosphorylated IRS4. Interacts with ADAM15. Interacts (via SH3 domain) with SFPQ. Interacts with EGFR and ERBB2. Interacts with STAP2. Interacts with PNX. Interacts with SFPQ. Interacts with PTK/ATK. Interacts with CTNNB1.
- Miscellaneous:
-
- The inhibitors bind to the ATP-binding pocket.
- SequenceCaution:
-
- Sequence=BAG62908.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PTK6 Gene
Protein Expression for PTK6 Gene
Selected DME Specific Peptides for PTK6 Gene
- Q13882:
-
- RDLAARN
- KWTAPEA
- KSDVWSFG
Post-translational modifications for PTK6 Gene
- Autophosphorylated. Autophosphorylation of Tyr-342 leads to an increase of kinase activity. Tyr-447 binds to the SH2 domain when phosphorylated and negatively regulates kinase activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PTK6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PTK6
- R&D Systems Antibodies for PTK6 (Brk)
-
Custom Antibody ServicesOriGene Antibodies for PTK6
- Novus Biologicals Antibodies for PTK6
-
Cloud-Clone Corp. Antibodies for PTK6
- Invitrogen Antibodies for PTK6
- antibodies-online Antibodies for PTK6: See all 138
- GeneTex PTK6 antibody for PTK6
Protein Products
- EMD Millipore Purified and/or Recombinant PTK6 Protein
-
OriGene Purified Proteins for PTK6
- Search Origene for MassSpec and Protein Over-expression Lysates for PTK6
- Origene Custom Protein Services for PTK6
- Sino Biological Recombinant Proteins for PTK6
- Sino Biological Cell Lysates for PTK6
-
Cloud-Clone Corp. Proteins for PTK6
- antibodies-online Proteins for PTK6: See all 12
- Search antibodies-online for peptides
- GeneTex Proteins for PTK6
Domains & Families for PTK6 Gene
Gene Families for PTK6 Gene
- HGNC:
- IUPHAR :
Protein Domains for PTK6 Gene
Suggested Antigen Peptide Sequences for PTK6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13882UniProtKB/Swiss-Prot:
PTK6_HUMAN :- The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.
- Domain:
-
- The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.
Function for PTK6 Gene
Molecular function for PTK6 Gene
- GENATLAS Biochemistry:
- protein tyrosine kinase 6,non receptor type,expressed in K-562,human leukemia cell and liver
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=83 uM for ATP {ECO:0000269 PubMed:12121988}; Vmax=37 nmol/min/mg enzyme {ECO:0000269 PubMed:12121988};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by EGF, NRG1 and IGF1. Inhibited by SOCS3 to phosphorylate STAT3. Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region. Interaction between Trp-184 within SH2-TK linker region and the catalytic domain appears essential for positive regulation of kinase activity.
- UniProtKB/Swiss-Prot Function:
- Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.
- UniProtKB/Swiss-Prot Function:
- Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.
Enzyme Numbers (IUBMB) for PTK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | TAS,IDA | 10913193 |
| GO:0005102 | receptor binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 10913193 |
Phenotypes for PTK6 Gene
- MGI mutant phenotypes for PTK6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTK6:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased IL-8 secretion
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased simian virus 40 (SV40) infection
- Decreased viability in HMC1.1 cells
Animal Models for PTK6 Gene
- MGI Knock Outs for PTK6:
-
- Ptk6 tm1Aty
Animal Model Products
-
Taconic Biosciences Mouse Models for PTK6
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTK6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PTK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
- Search ViGene Biosciences for PTK6
CRISPR Products
-
OriGene CRISPR knockouts for PTK6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTK6
- GenScript: Design CRISPR guide RNA sequences for PTK6
miRNA for PTK6 Gene
- miRTarBase miRNAs that target PTK6
-
- hsa-mir-5587-5p (MIRT542511)
- hsa-mir-6736-5p (MIRT542512)
- hsa-mir-4701-3p (MIRT542513)
- hsa-mir-1262 (MIRT542514)
- hsa-mir-6720-5p (MIRT542515)
- hsa-mir-6512-3p (MIRT542516)
- hsa-mir-542-3p (MIRT542517)
- hsa-mir-4252 (MIRT542518)
- hsa-mir-661 (MIRT542519)
- hsa-mir-6776-5p (MIRT542520)
- hsa-mir-191-3p (MIRT542521)
- hsa-mir-766-3p (MIRT542522)
- hsa-mir-6742-3p (MIRT542523)
- hsa-mir-6849-3p (MIRT542524)
- hsa-mir-1273g-3p (MIRT542525)
- hsa-mir-548s (MIRT665143)
- hsa-mir-4470 (MIRT665144)
- hsa-mir-3926 (MIRT665145)
- hsa-mir-3675-3p (MIRT665146)
- hsa-mir-454-5p (MIRT665147)
- hsa-mir-942-3p (MIRT665148)
- hsa-mir-652-5p (MIRT665149)
- hsa-mir-548as-3p (MIRT665150)
- hsa-mir-6086 (MIRT686071)
- hsa-mir-2467-3p (MIRT686072)
- hsa-mir-377-5p (MIRT686073)
- hsa-mir-1827 (MIRT686074)
- hsa-mir-4257 (MIRT686075)
- hsa-mir-4740-3p (MIRT686076)
- hsa-mir-3614-5p (MIRT686077)
- hsa-mir-6500-3p (MIRT686078)
- hsa-mir-6511a-5p (MIRT686079)
- hsa-mir-1910-3p (MIRT686080)
- hsa-mir-377-3p (MIRT724959)
- hsa-mir-4532 (MIRT724960)
- hsa-mir-1247-3p (MIRT724961)
- hsa-mir-622 (MIRT724962)
- hsa-mir-1306-5p (MIRT724963)
- hsa-mir-1228-3p (MIRT724964)
miRNA Products
- Search ViGene Biosciences for PTK6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PTK6
- Browse OriGene Inhibitory RNA Products For PTK6
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
Clone Products
- Sino Biological Human cDNA Clone for PTK6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTK6
- VectorBuilder custom plasmid, inducible vectors for PTK6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTK6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PTK6
-
ViGene Biosciences adenoviral particle packaged cDNA for PTK6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTK6 Gene
Localization for PTK6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTK6 Gene
- Cytoplasm. Nucleus. Cell projection, ruffle. Membrane. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IDA,IEA | 15572663 |
| GO:0005634 | nucleus | IEA,IDA | 10913193 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 15572663 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PTK6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by PTK6 |
.01
|
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | Signaling by ERBB2 | ||
| 5 | Mitotic G1-G1/S phases |
.83
|
|
Pathways by source for PTK6 Gene
2 BioSystems pathways for PTK6 Gene
20 Reactome pathways for PTK6 Gene
1 Qiagen pathway for PTK6 Gene
Interacting Proteins for PTK6 Gene
Selected Interacting proteins:
ENSP00000217185
Q13882-PTK6_HUMAN
for PTK6 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for PTK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | TAS | 8036022 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | -- |
| GO:0007260 | tyrosine phosphorylation of STAT protein | IDA | 16568091 |
| GO:0009968 | negative regulation of signal transduction | TAS | -- |
| GO:0010976 | positive regulation of neuron projection development | IMP | 17910947 |
Drugs & Compounds for PTK6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vandetanib | Approved April 2011 | Pharma | Target, inhibitor | VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Adenosine triphosphate | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for PTK6 Gene
mRNA/cDNA for PTK6 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (53) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTK6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PTK6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTK6
- GenScript: Design CRISPR guide RNA sequences for PTK6
miRNA Products
- Search ViGene Biosciences for PTK6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PTK6
- Browse OriGene Inhibitory RNA Products For PTK6
-
ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
Clone Products
- Sino Biological Human cDNA Clone for PTK6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTK6
- VectorBuilder custom plasmid, inducible vectors for PTK6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTK6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for PTK6 Gene
mRNA differential expression in normal tissues according to GTEx for PTK6 Gene
This gene is overexpressed in Esophagus - Mucosa (x14.2), Skin - Sun Exposed (Lower leg) (x6.4), Skin - Not Sun Exposed (Suprapubic) (x6.2), Colon - Transverse (x5.4), and Vagina (x4.9).
This gene is overexpressed in Cervix (64.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTK6 Gene
NURSA nuclear receptor signaling pathways regulating expression of PTK6 Gene:
PTK6SOURCE GeneReport for Unigene cluster for PTK6 Gene:
Hs.51133mRNA Expression by UniProt/SwissProt for PTK6 Gene:
Q13882-PTK6_HUMAN
Tissue specificity:
Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines.
Evidence on tissue expression from TISSUES for PTK6 Gene
- Skin(4.4)
- Blood(4.3)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for PTK6
-
OriGene qPCR primer pairs and template standards for PTK6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTK6 Gene
Orthologs for PTK6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTK6 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PTK6 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ptk6 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ptk6 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PTK6 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTK6 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PTK6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptk6 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptk6b 34 35 |
|
||
| ptk6a 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F09A5.2 36 |
|
|
|
| F57B9.8 36 |
|
|
- Species where no ortholog for PTK6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PTK6 Gene
(60) SIMAP similar genes for PTK6 Gene using alignment to 1 proteins:
- HCK
- FYN
- FRK
- EPHA2
- YES1
- SRC
- LYN
- IGF1R
- EPHA6
- GRB2
- FGR
- SRMS
- INSR
- EPHA4
- BLK
- BCR/ABL fusion
- LCK
- FER
- EPHA3
- BTK kinase deficient isoform 2
- BMX
- ABL2
- PTK2
- EPHB3
- EPHB2
- TEC
- TXK
- EPHB2 variant protein
- EPHA5
- DKFZp666O0110
- MATK
- BTK
- lsk
- TPM3-ROS1
- SLC34A2/ROS1 fusion
- SLC34A2/ROS fusion
- SLC34A2-ROS1
- SDC4-ROS1_S4
- R34
- SDC4-ROS1_S4
- R32
- SDC4-ROS1_S2
- R32
- ROS1
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- EZR-ROS1
- EPHB1
- CD74/ROS fusion
- CD74-ROS1_C6
- R32
- TNK2
- FGFR4
- FES
- CSK
- ITK
- FGFR2
- urf-ret
- FGFR3
- FGFR1
Variants for PTK6 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042747 | -- | 63,532,921(+) | CCGAT(A/T)TCTTC | intron-variant | |
| rs1000096831 | -- | 63,537,526(+) | TTAGC(A/G)CCCGC | upstream-variant-2KB | |
| rs1000142632 | -- | 63,531,825(+) | TCCCT(A/C/G)CCGGA | intron-variant | |
| rs1000689972 | -- | 63,535,667(+) | CAGAA(A/G)ACCAC | intron-variant | |
| rs1000956363 | -- | 63,536,336(+) | ACGAG(C/G)TCGTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv521n27 | CNV | loss | 19166990 |
| dgv522n27 | CNV | loss | 19166990 |
| dgv7667n54 | CNV | loss | 21841781 |
| esv2758806 | CNV | gain+loss | 17122850 |
| nsv1118925 | CNV | deletion | 24896259 |
| nsv470563 | CNV | loss | 18288195 |
| nsv521734 | CNV | loss | 19592680 |
| nsv586569 | CNV | loss | 21841781 |
| nsv586571 | CNV | loss | 21841781 |
| nsv586573 | CNV | loss | 21841781 |
| nsv834033 | CNV | gain | 17160897 |
| nsv834034 | CNV | loss | 17160897 |
| nsv953306 | CNV | deletion | 24416366 |
| nsv9825 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.01;
37.09% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PTK6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PTK6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTK6 Gene
Disorders for PTK6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dysgraphia |
|
|
| breast cancer |
|
Search PTK6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PTK6
No data available for UniProtKB/Swiss-Prot and Genatlas for PTK6 Gene
Publications for PTK6 Gene
- BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. (PMID: 19439179) Lukong K.E. … Richard S. (Cell. Signal. 2009) 3 4 22 64
- Brk is coamplified with ErbB2 to promote proliferation in breast cancer. (PMID: 18719096) Xiang B. … Muthuswamy S.K. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 22 64
- Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. (PMID: 18829532) Shen C.H. … Chen R.H. (Cancer Res. 2008) 3 4 22 64
- Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PMID: 17997837) Weaver A.M. … Silva C.M. (Breast Cancer Res. 2007) 3 4 22 64
- Identification of STAT3 as a specific substrate of breast tumor kinase. (PMID: 16568091) Liu L. … Reich N.C. (Oncogene 2006) 3 4 22 64
Products for PTK6 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PTK6
- EMD Millipore Purified and/or Recombinant PTK6 Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for PTK6 (Brk)
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- Custom Antibody ServicesOriGene Antibodies for PTK6
- Browse OriGene ELISA Kits
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Cloud-Clone Corp. Antibodies for PTK6
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- Taconic Biosciences Mouse Models for PTK6
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Addgene plasmids for PTK6
- antibodies-online Antibodies for PTK6: See all 138
- antibodies-online Kits for PTK6: See all 9
- antibodies-online Proteins for PTK6: See all 12
- Search antibodies-online for peptides
- GeneTex PTK6 antibody for PTK6
- GeneTex Proteins for PTK6
- ViGene Biosciences adenoviral particle packaged cDNA for PTK6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PTK6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PTK6 gene
- Search ViGene Biosciences for PTK6
- Search Santa Cruz Biotechnology (SCBT) for PTK6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTK6
- Horizon Cell Lines for PTK6
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTK6
- VectorBuilder custom plasmid, inducible vectors for PTK6
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PTK6 Gene
- (1) GeneCards
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- (74) Cloud-Clone Corp.
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