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PTK6 Gene(Protein Coding)

Protein Tyrosine Kinase 6

GCID:
GC20M063528
GIFtS:
66
Genes Participants
UDN Logo

Aliases for PTK6 Gene

Aliases for PTK6 Gene

  • Protein Tyrosine Kinase 6 2 3 5
  • PTK6 Protein Tyrosine Kinase 6 2 3
  • Tyrosine-Protein Kinase BRK 3 4
  • Breast Tumor Kinase 3 4
  • EC 2.7.10.2 4 61
  • BRK 3 4
  • Protein-Tyrosine Kinase BRK 3
  • Protein-Tyrosine Kinase 6 3
  • EC 2.7.10 61

External Ids for PTK6 Gene

Previous GeneCards Identifiers for PTK6 Gene

  • GC20M062037
  • GC20M061997
  • GC20M062839
  • GC20M062886
  • GC20M061630
  • GC20M062159
  • GC20M058889

Summaries for PTK6 Gene

Entrez Gene Summary for PTK6 Gene

  • The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for PTK6 Gene

PTK6 (Protein Tyrosine Kinase 6) is a Protein Coding gene. Diseases associated with PTK6 include Dysgraphia and Breast Cancer. Among its related pathways are Signaling by PTK6 and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is SRMS.

UniProtKB/Swiss-Prot for PTK6 Gene

  • Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.

  • Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.

Tocris Summary for PTK6 Gene

Gene Wiki entry for PTK6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTK6 Gene

Genomics for PTK6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for PTK6 Gene

Enhancers for PTK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G063536 1.7 FANTOM5 ENCODE dbSUPER 12.7 -0.4 -421 3.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PPDPF PTK6 FNDC11 SRMS SAMD10 PRPF6 UCKL1 YTHDF1 ENSG00000275812
GH20G063611 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -75.4 -75355 1.6 CTCF TFAP4 SAP130 MAX ZNF644 RAD21 TEAD3 RARA NR2F6 GATAD2A FNDC11 SRMS PTK6 STMN3 RGS19 LIME1 OPRL1 GMEB2 HELZ2 TPD52L2
GH20G063519 1.6 FANTOM5 ENCODE dbSUPER 10.4 +15.9 15915 4.0 HDGF PKNOX1 FOXA2 SIN3A ZBTB7B ZNF207 ZNF263 SP3 REST SMARCB1 PPDPF PTK6 EEF1A2 KCNQ2 CHRNA4 STMN3 GC20M063514
GH20G063533 1.2 ENCODE dbSUPER 12.7 +2.7 2707 2.3 BRCA1 ZNF48 YY1 KLF7 SMARCB1 SMARCA4 GLIS1 HNF4A WT1 SP7 PTK6 GC20M063514
GH20G063524 1 dbSUPER 14.5 +11.9 11902 2.4 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B YY1 ZNF121 GLIS2 ZNF143 FOS SRMS PTK6 LOC105372725 EEF1A2 FNDC11 GC20M063514
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTK6 on UCSC Golden Path with GeneCards custom track

Promoters for PTK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139917 -630 801 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Transcription factor binding sites by QIAGEN in the PTK6 gene promoter:

Genomic Location for PTK6 Gene

Chromosome:
20
Start:
63,528,001 bp from pter
End:
63,537,370 bp from pter
Size:
9,370 bases
Orientation:
Minus strand

Genomic View for PTK6 Gene

Genes around PTK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTK6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PTK6 Gene

Proteins for PTK6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PTK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13882-PTK6_HUMAN
    Recommended name:
    Protein-tyrosine kinase 6
    Protein Accession:
    Q13882
    Secondary Accessions:
    • B2RCR3
    • B4DW46
    • Q58F01

    Protein attributes for PTK6 Gene

    Size:
    451 amino acids
    Molecular mass:
    51834 Da
    Quaternary structure:
    • Interacts with GAP-A.p65 (By similarity). Interacts (via SH3 and SH2 domains) with KHDRBS1. Interacts (via SH3 and SH2 domains) with phosphorylated IRS4. Interacts with ADAM15. Interacts (via SH3 domain) with SFPQ. Interacts with EGFR and ERBB2. Interacts with STAP2. Interacts with PNX. Interacts with SFPQ. Interacts with PTK/ATK. Interacts with CTNNB1.
    Miscellaneous:
    • The inhibitors bind to the ATP-binding pocket.
    SequenceCaution:
    • Sequence=BAG62908.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTK6 Gene

    Alternative splice isoforms for PTK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTK6 Gene

Protein Expression for PTK6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PTK6 Gene

Q13882:
  • RDLAARN
  • KWTAPEA
  • KSDVWSFG

Post-translational modifications for PTK6 Gene

  • Autophosphorylated. Autophosphorylation of Tyr-342 leads to an increase of kinase activity. Tyr-447 binds to the SH2 domain when phosphorylated and negatively regulates kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for PTK6 Gene

Gene Families for PTK6 Gene

HGNC:
IUPHAR :

Protein Domains for PTK6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PTK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13882

UniProtKB/Swiss-Prot:

PTK6_HUMAN :
  • The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.
Domain:
  • The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in protein-protein interactions, but is likely more important for the regulation of catalytic activity.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.
genes like me logo Genes that share domains with PTK6: view

Function for PTK6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PTK6 Gene

GENATLAS Biochemistry:
protein tyrosine kinase 6,non receptor type,expressed in K-562,human leukemia cell and liver
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=83 uM for ATP {ECO:0000269 PubMed:12121988}; Vmax=37 nmol/min/mg enzyme {ECO:0000269 PubMed:12121988};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by EGF, NRG1 and IGF1. Inhibited by SOCS3 to phosphorylate STAT3. Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region. Interaction between Trp-184 within SH2-TK linker region and the catalytic domain appears essential for positive regulation of kinase activity.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.
UniProtKB/Swiss-Prot Function:
Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.

Enzyme Numbers (IUBMB) for PTK6 Gene

Gene Ontology (GO) - Molecular Function for PTK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS,IDA 10913193
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 10913193
genes like me logo Genes that share ontologies with PTK6: view
genes like me logo Genes that share phenotypes with PTK6: view

Animal Models for PTK6 Gene

MGI Knock Outs for PTK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTK6

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTK6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTK6 Gene

Localization for PTK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTK6 Gene

Cytoplasm. Nucleus. Cell projection, ruffle. Membrane. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTK6 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA,IEA 15572663
GO:0005634 nucleus IEA,IDA 10913193
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 15572663
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTK6: view

Pathways & Interactions for PTK6 Gene

genes like me logo Genes that share pathways with PTK6: view

Pathways by source for PTK6 Gene

2 BioSystems pathways for PTK6 Gene
1 Qiagen pathway for PTK6 Gene

SIGNOR curated interactions for PTK6 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PTK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 8036022
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007260 tyrosine phosphorylation of STAT protein IDA 16568091
GO:0009968 negative regulation of signal transduction TAS --
GO:0010976 positive regulation of neuron projection development IMP 17910947
genes like me logo Genes that share ontologies with PTK6: view

Drugs & Compounds for PTK6 Gene

Products:

  1. Drug

(3) Drugs for PTK6 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vandetanib Approved April 2011 Pharma Target, inhibitor VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for PTK6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PTK6: view

Transcripts for PTK6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PTK6 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(53) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTK6 Gene

Protein tyrosine kinase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTK6

Alternative Splicing Database (ASD) splice patterns (SP) for PTK6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - -
SP5: - - - -
SP6:

Relevant External Links for PTK6 Gene

GeneLoc Exon Structure for
PTK6
ECgene alternative splicing isoforms for
PTK6

Expression for PTK6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTK6 Gene

mRNA expression in normal human tissues for PTK6 Gene
mRNA expression by BioGPS for PTK6 GenemRNA expression by GTEx for PTK6 Gene

mRNA differential expression in normal tissues according to GTEx for PTK6 Gene

This gene is overexpressed in Esophagus - Mucosa (x14.2), Skin - Sun Exposed (Lower leg) (x6.4), Skin - Not Sun Exposed (Suprapubic) (x6.2), Colon - Transverse (x5.4), and Vagina (x4.9).

Protein differential expression in normal tissues from HIPED for PTK6 Gene

This gene is overexpressed in Cervix (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTK6 Gene



Protein tissue co-expression partners for PTK6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTK6 Gene:

PTK6

SOURCE GeneReport for Unigene cluster for PTK6 Gene:

Hs.51133

mRNA Expression by UniProt/SwissProt for PTK6 Gene:

Q13882-PTK6_HUMAN
Tissue specificity: Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines.

Evidence on tissue expression from TISSUES for PTK6 Gene

  • Skin(4.4)
  • Blood(4.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with PTK6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTK6 Gene

Orthologs for PTK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PTK6 34
  • 98.18 (n)
cow
(Bos Taurus)
 Mammalia PTK6 35 34
  • 85.52 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ptk6 34 16 35
  • 82.93 (n)
rat
(Rattus norvegicus)
 Mammalia Ptk6 34
  • 81.81 (n)
oppossum
(Monodelphis domestica)
 Mammalia PTK6 35
  • 69 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PTK6 35
  • 68 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PTK6 35
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ptk6 34
  • 57.58 (n)
zebrafish
(Danio rerio)
 Actinopterygii ptk6b 34 35
  • 55.4 (n)
ptk6a 35
  • 41 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea F09A5.2 36
  • 32 (a)
F57B9.8 36
  • 31 (a)
Species where no ortholog for PTK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTK6 Gene

ENSEMBL:
Gene Tree for PTK6 (if available)
TreeFam:
Gene Tree for PTK6 (if available)

Paralogs for PTK6 Gene

Variants for PTK6 Gene

Sequence variations from dbSNP and Humsavar for PTK6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000042747 -- 63,532,921(+) CCGAT(A/T)TCTTC intron-variant
rs1000096831 -- 63,537,526(+) TTAGC(A/G)CCCGC upstream-variant-2KB
rs1000142632 -- 63,531,825(+) TCCCT(A/C/G)CCGGA intron-variant
rs1000689972 -- 63,535,667(+) CAGAA(A/G)ACCAC intron-variant
rs1000956363 -- 63,536,336(+) ACGAG(C/G)TCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTK6 Gene

Variant ID Type Subtype PubMed ID
dgv521n27 CNV loss 19166990
dgv522n27 CNV loss 19166990
dgv7667n54 CNV loss 21841781
esv2758806 CNV gain+loss 17122850
nsv1118925 CNV deletion 24896259
nsv470563 CNV loss 18288195
nsv521734 CNV loss 19592680
nsv586569 CNV loss 21841781
nsv586571 CNV loss 21841781
nsv586573 CNV loss 21841781
nsv834033 CNV gain 17160897
nsv834034 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for PTK6 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTK6 Gene

Disorders for PTK6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTK6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dysgraphia
  • agraphia
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search PTK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTK6

Genetic Association Database (GAD)
PTK6
Human Genome Epidemiology (HuGE) Navigator
PTK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTK6
genes like me logo Genes that share disorders with PTK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTK6 Gene

Publications for PTK6 Gene

  1. BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. (PMID: 19439179) Lukong K.E. … Richard S. (Cell. Signal. 2009) 3 4 22 64
  2. Brk is coamplified with ErbB2 to promote proliferation in breast cancer. (PMID: 18719096) Xiang B. … Muthuswamy S.K. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 22 64
  3. Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. (PMID: 18829532) Shen C.H. … Chen R.H. (Cancer Res. 2008) 3 4 22 64
  4. Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PMID: 17997837) Weaver A.M. … Silva C.M. (Breast Cancer Res. 2007) 3 4 22 64
  5. Identification of STAT3 as a specific substrate of breast tumor kinase. (PMID: 16568091) Liu L. … Reich N.C. (Oncogene 2006) 3 4 22 64

Products for PTK6 Gene

  • Cloud-Clone Corp. Antibodies for PTK6
  • Cloud-Clone Corp. Proteins for PTK6
  • Cloud-Clone Corp Assay Kits for PTK6
  • Addgene plasmids for PTK6

Sources for PTK6 Gene

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