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PTK6 Gene

protein-coding   GIFtS: 68
GCID: GC20M062159

Protein Tyrosine Kinase 6

(Previous name: PTK6 protein tyrosine kinase 6)
  See related diseases
at
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Aliases
for PTK6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Kinase 61 2     EC 2.7.10.23 8
BRK2 3 5     Protein-Tyrosine Kinase 62
PTK6 Protein Tyrosine Kinase 61 2     Protein-Tyrosine Kinase BRK2
Breast Tumor Kinase2 3     EC 2.7.108
Tyrosine-Protein Kinase BRK2 3     

External Ids:    HGNC: 96171   Entrez Gene: 57532   Ensembl: ENSG000001012137   OMIM: 6020045   UniProtKB: Q138823   

Export aliases for PTK6 gene to outside databases

Previous GC identifers: GC20M062037 GC20M061997 GC20M062839 GC20M062886 GC20M061630 GC20M058889


Summaries
for PTK6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTK6 Gene:
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an
intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells
leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.
Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.
The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for PTK6 Gene:
PTK6 (protein tyrosine kinase 6) is a protein-coding gene. Diseases associated with PTK6 include band keratopathy, and recurrent corneal erosion. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and identical protein binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: PTK6_HUMAN, Q13882
Function: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways
that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to
be context dependent and differ depending on cell type, as well as its intracellular localization. A number of
potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins:
KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety
of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of
proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an
adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic
tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression
by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and
migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth
through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and
proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association
with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of
PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6
activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in
normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways
Function: Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins

Gene Wiki entry for PTK6 Gene


Genomic Views
for PTK6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTK6 gene promoter:
         AREB6   S8   AP-1   NRSF form 1   ATF-2   ARP-1   Pax-2a   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTK6 promoter sequence
   Search Chromatin IP Primers for PTK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

PTK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTK6 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062159:  view genomic region     (about GC identifiers)

Start:
 62,159,766 bp from pter      End:
 62,168,723 bp from pter
Size:
 8,958 bases      Orientation:
 minus strand

Proteins
for PTK6 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PTK6_HUMAN, Q13882 (See protein sequence)
Recommended Name: Protein-tyrosine kinase 6  
Size: 451 amino acids; 51834 Da
Subunit: Interacts with GAP-A.p65 (By similarity). Interacts (via SH3 and SH2 domains) with KHDRBS1. Interacts
(via SH3 and SH2 domains) with phosphorylated IRS4. Interacts with ADAM15. Interacts (via SH3 domain) with SFPQ.
Interacts with EGFR and ERBB2. Interacts with STAP2. Interacts with PNX. Interacts with SFPQ. Interacts with
PTK/ATK. Interacts with CTNNB1
Sequence caution: Sequence=BAG62908.1; Type=Erroneous translation; Note=Wrong choice of CDS;
2 PDB 3D structures from and Proteopedia for PTK6:
1RJA (3D)        2KGT (3D)    
Secondary accessions: B2RCR3 B4DW46 Q58F01
Alternative splicing: 2 isoforms:  Q13882-1   Q13882-2   

Explore the universe of human proteins at neXtProt for PTK6: NX_Q13882

Explore proteomics data for PTK6 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Autophosphorylation of Tyr-342 leads to an increase of kinase activity. Tyr-447 binds to the
    SH2 domain when phosphorylated and negatively regulates kinase activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • 3 DME Specific Peptides for PTK6 (Q13882)
     KWTAPEA  RDLAARN  KSDVWSFG 


    See PTK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243287.1  NP_005966.1  

    ENSEMBL proteins: 
     ENSP00000217185   ENSP00000442460  

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    Cloud-Clone Corp. Proteins for PTK6

    PTK6 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PTK6

    PTK6 Assay Products:

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    Cloud-Clone Corp. ELISAs for PTK6
    Cloud-Clone Corp. CLIAs for PTK6

    Domains /
    Families
    for PTK6 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: PTK6 protein tyrosine kinase 6
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q13882

    ProtoNet protein and cluster: Q13882

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: PTK6_HUMAN, Q13882
    Domain: The SH3 domain plays a major role in substrate interactions. The SH2 domain of PTK6 plays a role in
    protein-protein interactions, but is likely more important for the regulation of catalytic activity
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    PTK6 for domains           About GeneDecksing


    Function
    for PTK6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTK6_HUMAN, Q13882
    Function: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways
    that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to
    be context dependent and differ depending on cell type, as well as its intracellular localization. A number of
    potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins:
    KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety
    of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of
    proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an
    adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic
    tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression
    by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and
    migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth
    through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and
    proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association
    with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of
    PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6
    activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in
    normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways
    Function: Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by EGF, NRG1 and IGF1. Inhibited by SOCS3 to phosphorylate STAT3. Stabilized in the
    inactive form by an association between the SH3 domain and the SH2-TK linker region. Interaction between Trp-184
    within SH2-TK linker region and the catalytic domain appears essential for positive regulation of kinase activity
    Biophysicochemical properties: Kinetic parameters: KM=83 uM for ATP; Vmax=37 nmol/min/mg enzyme;

         Genatlas biochemistry entry for PTK6:
    protein tyrosine kinase 6,non receptor type,expressed in K-562,human leukemia cell and liver

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA10913193
    GO:0005515protein binding IPI10913193
         
    PTK6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTK6:
     Decreased viability in HMC1.1  

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ptk6):
     digestive/alimentary 

    PTK6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptk6tm1Aty for PTK6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTK6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTK6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTK6

    miRNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PTK6 (NM_005975)
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK6


    Localization
    for PTK6 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    PTK6_HUMAN, Q13882: Cytoplasm. Nucleus. Cell projection, ruffle. Membrane (By similarity). Note=Colocalizes with
    KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but
    cytoplasmic localization in cancer prostate
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol3
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA15572663
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA15572663
    GO:0005886plasma membrane ----

    PTK6 for ontologies           About GeneDecksing


    Pathways & Interactions
    for PTK6 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTK6 About    
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    		Focal Adhesion0.65
    2Sweet Taste Signaling
    		Sperm Motility0.37
    3Selected targets of p53
    		Selected targets of p53
    4EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTK6
        Sperm Motility

    2 BioSystems Pathways for PTK6
        Focal Adhesion
    EGFR1 Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTK6
    Interactions:

        GeneGlobe Interaction Network for PTK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for PTK6 (Q138821, 2, 3 ENSP000002171854) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFPQP232461, 2, 3, ENSP000003497484EBI-1383632,EBI-355453 MINT-7231528 MINT-7231563 MINT-7231550 MINT-7231537 MINT-7231572 I2D: score=1 STRING: ENSP00000349748
    PTK6Q138821, 2EBI-1383632,EBI-1383632 MINT-7309884 MINT-8033702
    ERBB3P218602, 3, ENSP000002671014MINT-74688 I2D: score=4 STRING: ENSP00000267101
    EGFRP005332, 3, ENSP000002754934MINT-74687 I2D: score=4 STRING: ENSP00000275493
    KHDRBS1Q076663, ENSP000003138294I2D: score=2 STRING: ENSP00000313829
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS8036022
    GO:0010976positive regulation of neuron projection development IMP17910947
    GO:0016477cell migration IDA15572663
    GO:0042503tyrosine phosphorylation of Stat3 protein IDA16568091
    GO:0042506tyrosine phosphorylation of Stat5 protein IDA17997837

    PTK6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTK6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTK6

    2 HMDB Compounds for PTK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for PTK6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 67.8 103 9749526 (4), 12121988 (4), 8036022 (4), 17997837 (4) (see all 32)



    PTK6 for compounds           About GeneDecksing



    Transcripts
    for PTK6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for PTK6 gene (2 alternative transcripts): 
    NM_001256358.1  NM_005975.3  

    Unigene Cluster for PTK6:

    Protein tyrosine kinase 6
    Hs.51133  [show with all ESTs]
    Unigene Representative Sequence: NM_005975
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217185(uc011aaz.1 uc002yfg.3 uc011aay.2 uc011aba.2)
    ENST00000542869
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat PTK6

    Additional mRNA sequence: 

    AK124082.1 AK301364.1 AK301691.1 AK315232.1 BC035843.1 X78549.1 

    9 DOTS entries:

    DT.303036  DT.101978621  DT.92051768  DT.100695118  DT.92421242  DT.100759966  DT.120832665  DT.95369810 
    DT.95369812 

    Selected AceView cDNA sequences (see all 53):

    CA433705 BM006730 BQ879667 BM761644 CR591121 BQ685944 BG676075 BM843462 
    AK124082 BQ685888 BC035843 BM850191 NM_005975 T29360 BM845045 BX362609 
    BM842269 BM842871 BM019354 BG739864 AA887585 AW328487 BX390765 BM006572 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTK6 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
    SP1:                    -     -     -                                                                                             
    SP2:                                -           -           -     -     -     -                                                   
    SP3:                                -                                                                                             
    SP4:                    -     -     -     -     -                 -                                                               
    SP5:                    -     -     -           -                                                                                 


    ECgene alternative splicing isoforms for PTK6

    Expression
    for PTK6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAGTCAT
    PTK6 Expression
    About this image

    PTK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    PTK6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.51133

    UniProtKB/Swiss-Prot: PTK6_HUMAN, Q13882
    Tissue specificity: Epithelia-specific. Very high level in colon and high levels in small intestine and prostate,
    and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage
    of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers,
    squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain,
    placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell
    lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines

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    Orthologs
    for PTK6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTK6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ptk61 , 5 PTK6 protein tyrosine kinase 61, 5 82.93(n)1
    80.4(a)1    		   2 (103.62 cM)5
    204591  NM_009184.21  NP_033210.11 
     1811937215 
    lizard
    (Anolis carolinensis)    		 Reptilia PTK66
    		 protein tyrosine kinase 6
    		 59(a)
    		 1 ↔ 1
    		 4(154306508-154324113)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia ptk61 protein tyrosine kinase 6 57.58(n)
    51.59(a)    		   100490792  XM_002942383.2  XP_002942429.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii BQ262729.12   -- 72.97(n)    BQ262729.1 


    ENSEMBL Gene Tree for PTK6 (if available)
    TreeFam Gene Tree for PTK6 (if available)

    Paralogs
    for PTK6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTK6 gene
    FRK2  LCK2  BLK2  LYN2  FGR2  YES12  HCK2  ABL12  
    SRC2  FYN2  ABL22  SRMS2  
    Selected SIMAP similar genes for PTK6 using alignment to 1 protein entry:     PTK6_HUMAN(see all similar genes):
    FRK    FYN    HCK    EPHA2    YES1    SRC
    EPHA6    FGR    GRB2    IGF1R    LYN    BLK
    EPHA4    INSR    SRMS    BCR/ABL fusion    ABL2    BMX

    PTK6 for paralogs           About GeneDecksing



    Genomic Variants
    for PTK6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTK6 (see all 439)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1921478301,2
    		C--62159283(+) CTGATA/TGCAAA 2 -- ds50010--------
    rs1486236031,2
    		C--62159332(+) TGACCA/GAAGAC 2 -- ds50010--------
    rs1844639651,2
    		--62159445(+) ATAACA/CAAAAT 2 -- ds50010--------
    rs1882853031,2
    		--62159467(+) ACATTA/GCACCA 2 -- ds50010--------
    rs1863321,2
    		C,F,A,H--62159468(-) ctggtG/Acaatg 2 -- ds500126Minor allele frequency- A:0.40NS MN EA NA WA CSA 2500
    rs48095781,2
    		C,F,A,H--62159496(+) gtgagT/Atagga 2 -- ds50016Minor allele frequency- A:0.47NA EA 250
    rs3106441,2
    		C,F,A,H--62159504(-) gatatA/Gtatcc 2 -- ds500122Minor allele frequency- G:0.38MN NS EA NA WA CSA 2530
    rs1420613791,2
    		--62159511(+) TATCAC/TAGGAT 2 -- ds50010--------
    rs761186781,2
    		F--62159566(+) CATATC/TAAAAC 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs733244421,2
    		C--62159572(+) AAAACC/TAAACC 2 -- ds50012Minor allele frequency- T:0.44WA 120

    HapMap Linkage Disequilibrium report for PTK6 (62159766 - 62168723 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTK6 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv521n27CNV Loss19166990
    nsv913213CNV Loss21882294
    dgv4618n71CNV Loss21882294
    dgv4643n71CNV Loss21882294
    nsv913207CNV Loss21882294
    nsv521734CNV Loss19592680
    dgv4639n71CNV Loss21882294
    nsv470563CNV Loss18288195
    dgv522n27CNV Loss19166990
    nsv913190CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing PTK6:
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing PTK6
    DNA2.0 Custom Variant and Variant Library Synthesis for PTK6

    Disorders / Diseases
    for PTK6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602004    OMIM disorders: --

    20 diseases for PTK6:    
    About MalaCards
    band keratopathy    recurrent corneal erosion    keratopathy    oral squamous cell carcinoma
    prostate adenocarcinoma    esophageal squamous cell carcinoma    laryngeal squamous cell carcinoma    squamous cell carcinoma
    esophagitis    laryngitis    breast cancer    prostatitis
    ovarian cancer    adenocarcinoma    melanoma    prostate cancer
    endotheliitis    lung cancer    neuronitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for PTK6:
    Recurrent corneal erosion

    PTK6 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for PTK6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 57.9 25 19661439 (4), 12902983 (4), 19439179 (2), 8940083 (1) (see all 10)
    breast cancer 53.1 53 17997837 (6), 17483331 (4), 18719096 (3), 17299391 (3) (see all 17)
    tumors 37.6 94 12833144 (4), 17483331 (3), 19661439 (3), 18829532 (3) (see all 24)
    carcinoma 13 10 16855388 (3), 12833144 (1), 19661439 (1), 18829532 (1)
    carcinoma squamous cell 0 1 15870689 (1)
    cancer 0 7 12833144 (1), 18719096 (1), 15572663 (1), 15075665 (1) (see all 5)

    Genetic Association Database (GAD): PTK6
    Human Genome Epidemiology (HuGE) Navigator: PTK6 (3 documents)

    Export disorders for PTK6 gene to outside databases

    Publications
    for PTK6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTK6 gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with PTK6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PubMed id 17997837)1, 2, 9 Weaver A.M. and Silva C.M. (Breast Cancer Res. 2007)
    2. BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. (PubMed id 19439179)1, 2, 9 Lukong K.E.... Richard S. (Cell. Signal. 2009)
    3. Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. (PubMed id 18829532)1, 2, 9 Shen C.H.... Chen R.H. (Cancer Res. 2008)
    4. Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. (PubMed id 12121988)1, 2, 9 Qiu H. and Miller W.T. (J. Biol. Chem. 2002)
    5. Identification of STAT3 as a specific substrate of breast tumor kinase. (PubMed id 16568091)1, 2, 9 Liu L.... Reich N.C. (Oncogene 2006)
    6. Regulated association of protein kinase B/Akt with breast tumor kinase. (PubMed id 15539407)1, 2, 9 Zhang P....Lange C.A. (J. Biol. Chem. 2005)
    7. Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. (PubMed id 15572663)1, 2, 9 Chen H.Y.... Chen R.H. (Mol. Cell. Biol. 2004)
    8. Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. (PubMed id 12833144)1, 2, 9 Derry J.J.... Tyner A.L. (Oncogene 2003)
    9. Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. (PubMed id 9749526)1, 2, 9 Lee H.-Y.... Lee S.-T. (Mol. Cells 1998)
    10. Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk. (PubMed id 9333026)1, 2, 9 Mitchell P.J.... Crompton M.R. (Oncogene 1997)

    External Searches for PTK6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTK6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5753 HGNC: 9617 AceView: PTK6 Ensembl:ENSG00000101213 euGenes: HUgn5753
    ECgene: PTK6 H-InvDB: PTK6

    Other Databases showing PTK6 gene

    (According to HUGE)
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    Specialized Databases showing PTK6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PTK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTK6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTK6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for PTK6 gene:
    Search GeneIP for patents involving PTK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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