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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTK2B Gene

protein-coding   GIFtS: 71
GCID: GC08P027224

protein tyrosine kinase 2 beta

(Previous names: protein tyrosine kinase 2 beta, PTK2B protein tyrosine...)
(Previous symbol: FAK2)
 Explore 84 diseases affiliated with
PTK2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTK2B    

Aliases
for PTK2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Kinase 2 Beta1     Focal Adhesion Kinase 22 3
FAK21 2 3 5     Proline-Rich Tyrosine Kinase 22 3
PYK21 2 3 5     Related Adhesion Focal Tyrosine Kinase2 3
CADTK1 2 3     CAK-Beta1
CAKB1 2 3     FADK 22 3
RAFTK1 2 3     EC 2.7.10.23 8
PTK1 2     FADK22
PTK2B Protein Tyrosine Kinase 2 Beta1 2     PKB2
Calcium-Dependent Tyrosine Kinase2 3     Protein Kinase B2
Calcium-Regulated Non-Receptor Proline-Rich Tyrosine Kinase2 3     Protein-Tyrosine Kinase 2-Beta2
Cell Adhesion Kinase Beta2 3     EC 2.7.108

External Ids:    HGNC: 96121   Entrez Gene: 21852   Ensembl: ENSG000001208997   OMIM: 6012125   UniProtKB: Q142893   

Export aliases for PTK2B gene to outside databases

Previous GC identifers: GC08P027003 GC08P027685 GC08P027190 GC08P025714


Summaries
for PTK2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTK2B:
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels
and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling
intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the
downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and
activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor
activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind
CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded
protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to
kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
Function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell
polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral
immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic
B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates
cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses.
Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity
of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors,
G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to
cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to
the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and
substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the
AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes
activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1.
Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in
the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a
scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and
'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation
of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by
phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates
ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2

Gene Wiki entry for PTK2B


Genomic Views
for PTK2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTK2B gene promoter:
         STAT1   NRSF form 1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PTK2B promoter sequence
   Search SABiosciences Chromatin IP Primers for PTK2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTK2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.1

PTK2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTK2B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P027224:  view genomic region     (about GC identifiers)

Start:
 27,168,999 bp from pter      End:
 27,316,903 bp from pter
Size:
 147,905 bases      Orientation:
 plus strand

Proteins
for PTK2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289 (See protein sequence)
Recommended Name: Protein-tyrosine kinase 2-beta  
Size: 1009 amino acids; 115875 Da
Subunit: Homodimer, or homooligomer. Interacts with SIRPA and SH2D3C. Interacts with ARHGAP10. Interacts with DLG4 (By
similarity). Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form
interacts with SRC (via SH2 domain) and SRC family members. Forms a signaling complex with EPHA1, LCK and
phosphatidylinositol 3-kinase; upon activation by EFNA1. Interacts with GRB2 (via SH2 domain). Interacts with P53/TP53
and MDM2. Interacts with MYLK. Interacts with BCAR1. Interacts with PDPK1. Interacts (hypophosphorylated) with PXN.
Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1. Interacts with LPXN and PTPN12
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic
side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction
with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery
Miscellaneous: Promotes bone resorption, and thus PTK2B/PYK2 inhibitors might be used to treat osteoporosis
6/18 PDB 3D structures from and Proteopedia for PTK2B (see all 18):
2FO6 (3D)        2LK4 (3D)        3CC6 (3D)        3ET7 (3D)        3FZO (3D)        3FZP (3D)    
Secondary accessions: D3DST0 Q13475 Q14290 Q16709 Q6PID4
Alternative splicing: 2 isoforms:  Q14289-1   Q14289-2   

Explore the universe of human proteins at neXtProt for PTK2B: NX_Q14289

Post-translational modifications:

  • Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium
    • concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS). Tyr-402
    is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in
    trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation
    at Tyr-402 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-579; Tyr-580 and
    Tyr-881. Phosphorylation at Tyr-881 is important for interaction with GRB2. Phosphorylated on tyrosine residues upon
    activation of FGR and PKC. Recruitment by NPHP1 to cell matrix adhesions initiates Tyr-402 phosphorylation. In
    monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II,
    thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity.
    Phosphorylation by MYLK promotes ITGB2 activation and is thus essential to trigger neutrophil transmigration during
    lung injury. Dephosphorylated by PTPN121
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14289

    • 4/6 DME Specific Peptides for PTK2B (Q14289) (see all 6)
     RLPIKWM  VCMWEIL  PTANLDR  PESINFRRFT 

    PTK2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_004094.3  NP_775266.1  NP_775267.1  NP_775268.1  

    ENSEMBL proteins: 
     ENSP00000380638   ENSP00000429694   ENSP00000430404   ENSP00000332816   ENSP00000428271  
     ENSP00000416174   ENSP00000427931   ENSP00000428837   ENSP00000380634   ENSP00000342242  
     ENSP00000440926   ENSP00000391995  
    Reactome Protein details: Q14289
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PTK2B Protein
    R&D Systems Recombinant & Natural Proteins for PTK2B (PYK2/FAK2)
    Enzo Life Sciences proteins for PTK2B
    OriGene Purified Proteins (see all 2): PTK2B
    OriGene Protein Over-expression Lysate (see all 4): PTK2B
    OriGene Custom Protein Services for PTK2B 
    GenScript Purified and Recombinant Proteins for PTK2B
    Novus Biologicals PTK2B Proteins
    Novus Biologicals PTK2B Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PTK2B
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----


    PTK2B for ontologies           About GeneDecksing



    PTK2B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTK2B
    R&D Systems Antibodies for PTK2B (PYK2/FAK2)
    Cell Signaling Technology (CST) Antibodies for PTK2B  (Pyk2)
    OriGene Antibodies (see all 3): PTK2B
    OriGene Custom Antibody Services for PTK2B 
    GenScript Custom Superior Antibodies Services for PTK2B
    Novus Biologicals PTK2B Antibodies
    Abcam antibodies for PTK2B 
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    ThermoFisher Antibodies for PTK2B

    Assay Products for PTK2B: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PTK2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTK2B for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR019748 FERM_central
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR005189 Focal_adhesion_kin_target_dom

    Graphical View of Domain Structure for InterPro Entry Q14289

    ProtoNet protein and cluster: Q14289

    2 Blocks protein families:
    IPB005189 Focal adhesion targeting region
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 protein kinase domain


    Function
    for PTK2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
    Function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell
    polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral
    immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic
    B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates
    cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses.
    Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity
    of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors,
    G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to
    cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to
    the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and
    substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the
    AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes
    activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1.
    Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in
    the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a
    scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and
    'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation
    of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by
    phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates
    ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated in response to stimuli that lead to increased intracellular Ca(2+) levels; this activation
    is indirect and may be mediated by calcium-mediated production of reactive oxygen species (ROS). Activated by
    autophosphorylation at Tyr-402; this creates a binding site for SRC family kinases and leads to phosphorylation at
    additional tyrosine residues. Phosphorylation at Tyr-402, Tyr-579 and Tyr-580 is required for optimal kinase activity.
    Inhibited by PF-562,271, BIRB796, PF-4618433 and by PF-431396, PF-2318841 and their derivatives. Inhibited by
    sulfoximine-substituted trifluoromethylpyrimidines. Inhibited by 4-amino and 5-aryl substituted pyridinone compounds

         Genatlas biochemistry entry for PTK2B:
    focal adhesion kinase 2

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): PTK2B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTK2B
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PTK2B (see all 21):
    hsa-miR-4272 hsa-miR-517a hsa-miR-517c hsa-miR-517b hsa-miR-1184 hsa-miR-330-3p hsa-miR-3121-3p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: PTK2B 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of PTK2B Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTK2B (see all 7)
    OriGene shRNA RFP: PTK2B
    OriGene siRNA: PTK2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTK2B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PTK2B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2B (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2B (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK2B (NM_173174)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK2B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PTK2B
    Search LifeMap BioReagents cell lines for PTK2B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK2B

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS8939945
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA7544443
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI18086875


    PTK2B for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PTK2B:
     Decreased Salmonella enterica   Decreased substrate adherent c  Decreased viability in CMK cel  Decreased viability of wild-ty 
     Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-outs for PTK2B: Ptk2btm1Okig Ptk2btm1Schl
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptk2b):
     cardiovascular system  cellular  homeostasis/metabolism  immune system  muscle 

    PTK2B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTK2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/72 super-pathways (see all 72) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Angiotensin activation of ERK
    		Development Angiotensin activation of ERK1.00
    		Development ACM2 and ACM4 activation of ERK0.74
    		Development_Angiotensin activation of ERK0.98
    		Development_G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Translation_Translation regulation by Alpha-1 adrenergic receptors
    		Translation_Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development_Activation of ERK by Alpha-1 adrenergic receptors0.64
    		Translation Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development Activation of ERK by Alpha-1 adrenergic receptors0.64
    4Development_Endothelin-1/EDNRA transactivation of EGFR
    		Development_Endothelin-1/EDNRA transactivation of EGFR1.00
    		Development Endothelin-1/EDNRA signaling0.41
    		Development Endothelin-1/EDNRA transactivation of EGFR1.00
    		Development_Endothelin-1/EDNRA signaling0.41
    5Development_A3 receptor signaling
    		Development A3 receptor signaling1.00
    		G-protein signaling_G-Protein alpha-q signaling cascades0.53
    		Development_A3 receptor signaling1.00
    		G-protein signaling G-Protein alpha-q signaling cascades0.53

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/18 EMD Millipore Pathways for PTK2B (see all 18)
        Chemotaxis CXCR4 signaling pathway
    Transcription Androgen Receptor nuclear signaling
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades

    5/44 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTK2B (see all 44)
        RhoA Pathway
    Fc-GammaR Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling

    2 Cell Signaling Technology (CST) Pathways for PTK2B
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    5/18 GeneGo (Thomson Reuters) Pathways for PTK2B (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development Angiotensin signaling via PYK2
    Chemotaxis CXCR4 signaling pathway

    5/20 BioSystems Pathways for PTK2B (see all 20) 
        Oncostatin M Signaling Pathway
    EGFR1 Signaling Pathway
    IL-2 Signaling Pathway
    B Cell Receptor Signaling Pathway
    IL-5 Signaling Pathway

    5/7        Reactome Pathways for PTK2B (see all 7)
        Interleukin-2 signaling
    Signal regulatory protein (SIRP) family interactions
    Cytokine Signaling in Immune system
    Pyk2 is activated following IL2 stimulation
    Signaling by Interleukins


    5         Kegg Pathways  (Kegg details for PTK2B):
        Calcium signaling pathway
    Chemokine signaling pathway
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    GnRH signaling pathway


    PTK2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTK2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/127 Interacting proteins for PTK2B (Q142891, 2, 3 ENSP000003328164) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8037532 MINT-8037517 I2D: score=4 STRING: ENSP00000357656
    MAP3K4Q9Y6R42, 3, ENSP000003759864MINT-51385 MINT-51384 I2D: score=3 STRING: ENSP00000375986
    MATKP426792, 3MINT-8037577 MINT-8037562 I2D: score=3 
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-68515 I2D: score=2 STRING: ENSP00000307387
    RHOUQ7L0Q81, 3, ENSP000003556524EBI-2211226,EBI-1638043 I2D: score=1 STRING: ENSP00000355652
    About this table

    Gene Ontology (GO): 5/84 biological process terms (GO ID links to tree view) (see all 84):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0000302response to reactive oxygen species ----
    GO:0001525angiogenesis ----
    GO:0001556oocyte maturation IEA--
    GO:0001666response to hypoxia IEA--


    PTK2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTK2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTK2B for compounds           About GeneDecksing

    EMD Millipore small molecules for PTK2B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTK2B

    10/13 HMDB Compounds for PTK2B (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----

    3 DrugBank Compounds for PTK2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LeflunomideLeflunomidum [INN-Latin] (see all 2)75706-12-6targetantagonist17103252 19149483 17604599
    Genistein4',5, 7-Trihydroxyisoflavone (see all 4)446-72-0target--17139284 17016423
    4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide-- --target--10592235

    10/145 Novoseek chemical compound relationships for PTK2B gene (see all 145)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 92.8 1858 10037772 (9), 10749687 (9), 11739373 (6), 8695788 (6) (see all 99)
    herbimycin a 90.3 100 9028864 (2), 7691610 (2), 16696126 (2), 8392438 (2) (see all 83)
    genistein 88.9 249 9667736 (4), 8442770 (3), 8891338 (3), 18718176 (2) (see all 99)
    erbstatin 78.2 16 14515350 (1), 9248222 (1), 7852849 (1), 10773618 (1) (see all 9)
    phosphotyrosine 73.1 17 11208605 (1), 8920763 (1), 10773618 (1), 18503146 (1) (see all 15)
    beta-hydroxyisovalerylshikonin 70 16 14551501 (6), 12592388 (2), 12716473 (2)
    ag 1478 68.3 4 9722539 (1), 18667434 (1), 18182168 (1), 19946718 (1)
    ag957 68.3 3 9823945 (1), 12380934 (1)
    ag 213 68.2 2 1375248 (1)
    ag 18 67.1 3 12634073 (1), 19251944 (1), 11467832 (1)

    Search CenterWatch for drugs/clinical trials and news about PTK2B / FAK2 

    Transcripts
    for PTK2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTK2B gene (4 alternative transcripts): 
    NM_004103.4  NM_173174.2  NM_173175.2  NM_173176.2  

    Unigene Cluster for PTK2B:

    PTK2B protein tyrosine kinase 2 beta
    Hs.491322  [show with all ESTs]
    Unigene Representative Sequence: NM_173174
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000397501(uc003xfn.2) ENST00000519650 ENST00000522338 ENST00000521164
    ENST00000346049(uc003xfp.2) ENST00000522517 ENST00000412793 ENST00000496920
    ENST00000517339(uc010luq.1) ENST00000521000 ENST00000519512 ENST00000397497(uc003xfr.1 uc003xfs.1)
    ENST00000461615 ENST00000495097 ENST00000482543 ENST00000522245 ENST00000338238
    ENST00000544172(uc022ate.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): PTK2B
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTK2B
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PTK2B (see all 21):
    hsa-miR-4272 hsa-miR-517a hsa-miR-517c hsa-miR-517b hsa-miR-1184 hsa-miR-330-3p hsa-miR-3121-3p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: PTK2B 3' UTR sequence
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of PTK2B Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTK2B (see all 7)
    OriGene shRNA RFP: PTK2B
    OriGene siRNA: PTK2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTK2B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2B (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2B (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK2B (NM_173174)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK2B 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTK2B
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    Additional cDNA sequence: 

    AB209085.1 AK128371.1 AY429564.1 BC036651.2 BC042599.2 D45853.1 L49207.1 U33284.1 
    U43522.1 

    14 DOTS entries:

    DT.95360491  DT.95226435  DT.100816481  DT.100035969  DT.101971785  DT.100816479  DT.40227837  DT.120647184 
    DT.120647207  DT.91747726  DT.92005520  DT.97854200  DT.120647181  DT.92043930 

    24/232 AceView cDNA sequences (see all 232):

    AA831122 AA904030 AI913993 BM980790 CA449933 AI590090 NM_173176 NM_173174 
    CD369939 AA464439 AA477775 R85257 CB156700 CB850679 CR613708 AA814433 
    AA938078 BF932497 NM_004103 AA507650 BM712234 CA446390 AA826177 NM_173175 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PTK2B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:        -     -     -           -     -           -                                                     -           -                                       
    SP2:                                -     -           -                                                     -           -                                       
    SP3:                                                                                                                                                            
    SP4:                                                  -                                                                                                         
    SP5:              -     -           -     -           -                                                                                                         

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                                  -                                                   
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PTK2B

    Expression
    for PTK2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTK2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTTGCATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTK2B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTK2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTK2B

    SOURCE GeneReport for Unigene cluster: Hs.491322

    UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
    Tissue specificity: Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney
    (at protein level). Also expressed in spleen and lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including PTK2B: 
              HIV Host Response in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Osmotic Stress in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK2B

    Orthologs
    for PTK2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTK2B gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PTK2B1 PTK2B protein tyrosine kinase 2 beta 79(n)
    80.16(a)    		   421998  XM_003641070.1  XP_003641118.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PTK2B6
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343696.1(210677-265559)
    zebrafish
    (Danio rerio)    		 Actinopterygii AJ490510.22   -- 73.7(n)   245950  AJ490510.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea kin-323 protein kinase 30(a)
    (best of 2)    		     --


    ENSEMBL Gene Tree for PTK2B (if available)
    TreeFam Gene Tree for PTK2B (if available) 

    Paralogs
    for PTK2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTK2B gene
    SYK2  TNK12  JAK22  JAK32  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  PTK22  ERBB22  ZAP702  EGFR2  
    18/20 SIMAP similar genes for PTK2B using alignment to 7 protein entries:     FAK2_HUMAN (see all proteins) (see all similar genes):
    ABL1    EPHA2    FES    tec    PTK2    BTK kinase deficient isoform 6
    DKFZp666O0110    HCK    DKFZp686M05208    DKFZp434L0319    ERBB4    CSK
    FGR    BTK kinase deficient isoform 2    FGFR1    MET    FLT1    NEK6

    PTK2B for paralogs           About GeneDecksing



    Genomic Variants
    for PTK2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2748 NCBI SNPs in PTK2B are shown (see all 2748)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2012742821,2
    		C,other25838835(+) TGAATC/TGTATT 8 R C mis10--------
    rs1136762631,2
    		--25712964(+) GATAAC/TACAAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1139703241,2
    		F--25713252(+) AGCACG/AGGCCC 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1121415831,2
    		F--25713275(+) TGAAGA/CAGCAG 1 -- us2k11Minor allele frequency- C:0.01EA 288
    rs1129975481,2
    		--25713931(+) CACCCA/GCCCGG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs70061831,2
    		C,F,H,--25713944(+) GCCAAC/AGCCCG 1 -- us2k18Minor allele frequency- A:0.10NS EA NA WA 660
    rs126795031,2
    		C,F,H,--25713971(+) AATCGC/TCCAGT 1 -- us2k15Minor allele frequency- T:0.05NS EA NA 420
    rs170569891,2
    		C,F,H,--25714229(+) TTCCGG/ACTGCA 1 -- ut5116Minor allele frequency- A:0.09NA NS EA WA 1628
    rs70057461,2
    		C,F,H,--25714399(+) CCTATG/ACCACT 1 -- int16Minor allele frequency- A:0.03NS EA WA 540
    rs770823381,2
    		C,--25714544(+) TCATCA/CTGTTT 1 -- int12Minor allele frequency- C:0.09CSA WA 120

    HapMap Linkage Disequilibrium report for PTK2B (27168999 - 27316903 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PTK2B
         2 Indels: 10910 100304

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTK2B
    DNA2.0 Custom Variant and Variant Library Synthesis for PTK2B

    Disorders / Diseases
    for PTK2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTK2B for disorders           About GeneDecksing

    OMIM gene information: 601212    OMIM disorders: --

    UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
  • Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion, in
    • tumor formation and metastasis. Elevated PTK2B/PYK2 expression is seen in gliomas, hepatocellular carcinoma, lung
    cancer and breast cancer

    20/84 diseases for PTK2B (see all 84):    About MalaCards
    dna topoisomerase i    traumatic brain injury    transient cerebral ischemia    brain injury
    crescentic glomerulonephritis    myeloproliferative disorder    laryngeal squamous cell carcinoma    insulin resistance
    adenoid cystic carcinoma    malignant glioma    retinal degeneration    systemic lupus erythematosus
    cystic fibrosis    acute promyelocytic leukemia    squamous cell carcinoma    myeloid leukemia
    lupus erythematosus    gangliosidosis    rheumatoid arthritis    chronic myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for PTK2B:
    Gangliosidosis

    10/68 Novoseek disease relationships for PTK2B gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 45.6 7 9566916 (1), 17605888 (1), 12488463 (1), 15087031 (1) (see all 7)
    hypo-osmolality 35.8 5 10811968 (3), 10381589 (2)
    leukemia 27 14 9569020 (2), 7488237 (1), 11114726 (1), 14636885 (1) (see all 12)
    tumors 25.2 61 7475883 (4), 8442941 (4), 8179861 (3), 20074345 (3) (see all 34)
    sarcoma avian 24.6 3 8278385 (1), 1309253 (1)
    blast crisis 23.2 1 15087031 (1)
    glioma 22.2 36 16962067 (4), 15499613 (3), 15967096 (3), 12900387 (2) (see all 14)
    necrosis 14.7 12 12515814 (2), 8778024 (1), 10521452 (1), 8739563 (1) (see all 9)
    cholera 11 1 9028864 (1)
    breast cancer 10.6 47 18832579 (5), 10713673 (3), 1380891 (3), 14654952 (3) (see all 17)

    Human Genome Epidemiology (HuGE) Navigator: PTK2B (12 documents)

    Export disorders for PTK2B gene to outside databases

    Publications
    for PTK2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTK2B gene, integrated from 9 sources (see all 1039):
    (articles sorted by number of sources associating them with PTK2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. (PubMed id 7499242)1, 2, 3, 9 Avraham S.... Avraham H. (1995)
    2. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. (PubMed id 7544443)1, 2, 3, 9 Lev S.... Schlessinger J. (1995)
    3. Pyk2 inhibition of p53 as an adaptive and intrinsic m echanism facilitating cell proliferation and survival. (PubMed id 19880522)1, 2, 9 Lim S.T....Schlaepfer D.D. (2010)
    4. Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation. (PubMed id 18765415)1, 2, 9 Sun C.K....Fan S.T. (2008)
    5. Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. (PubMed id 19086031)1, 2, 9 Rufanova V.A....Sorokin A. (2009)
    6. A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. (PubMed id 9545257)1, 2, 9 Li X.... Earp H.S. (1998)
    7. T cell receptor activation leads to two distinct phas es of Pyk2 activation and actin cytoskeletal rearrangement in human T cells. (PubMed id 20381867)1, 2, 9 Collins M....Houtman J.C. (2010)
    8. Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. (PubMed id 11493697)1, 2, 9 Benzing T.... Walz G. (2001)
    9. A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation. (PubMed id 19207108)1, 2, 9 Gao C. and Blystone S.D. (2009)
    10. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PubMed id 17329398)1, 2, 9 Sahu S.N....Gupta A. (2007)

    External Searches for PTK2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTK2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2185 HGNC: 9612 AceView: PTK2B Ensembl:ENSG00000120899 euGenes: HUgn2185
    ECgene: PTK2B Kegg: 2185 H-InvDB: PTK2B

    Other Databases showing PTK2B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTK2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTK2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTK2B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTK2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTK2B gene:
    Search GeneIP for patents involving PTK2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PTK2B gene

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    About This Section

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