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PTK2B Gene

protein-coding GIFtS: 71

GC08P027224

PTK2B protein tyrosine kinase 2 beta
(Previous name: protein tyrosine kinase 2 beta )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FAK2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CADTK ^¹, ², ³
CAKB ^¹, ²
EC 2.7.10.2 ^³
FADK2 ^²
FAK2 ^², ³, ⁵
FRNK ^²
OTTHUMP00000128275 ^²
OTTHUMP00000162913 ^²
PKB ^²
PTK ^¹, ²
PYK2 ^¹, ², ³, ⁵
RAFTK ^¹, ², ³

Descriptions
CAK beta ^², ³
Calcium-dependent tyrosine kinase ^², ³
Cell adhesion kinase beta ^², ³
FADK 2 ^³
Focal adhesion kinase 2 ^², ³
PTK2B protein tyrosine kinase 2 beta ^²
Proline-rich tyrosine kinase 2 ^², ³
Related adhesion focal tyrosine kinase ^², ³
protein kinase B ^²
protein tyrosine kinase 2 beta ^¹, ²

External Ids
HGNC: 9612¹
Entrez Gene: 2185²
UniProtKB: Q14289³
Ensembl: ENSG00000120899⁷

Search outside databases for aliases for PTK2B gene

Previous GC identifers: GC08P027003 GC08P027685 GC08P027190

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PTK2B:

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced

regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein

may represent an important signaling intermediate between neuropeptide-activated receptors or

neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal

activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response

to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor

activation, membrane depolarization, or protein kinase C activation. This protein has been shown

to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2

domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases

but lacks significant sequence similarity to kinases from other subfamilies. Four transcript

variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289

Function: Involved in calcium induced regulation of ion channel and activation of the map kinase

signaling pathway. May represent an important signaling intermediate between neuropeptide

activated receptors or neurotransmitters that increase calcium flux and the downstream signals

that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the

voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the

stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA

'Tyr-125' phosphorylation

Gene Wiki entry for PTK2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PTK2B gene

Entrez Gene cytogenetic band: 8p21.1 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.1

PTK2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P027224: (about GC identifiers)

Start:	27,224,916 bp from pter
End:	27,372,820 bp from pter
Size:	147,905 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_023666.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289 (See protein sequence)

Recommended Name: Protein tyrosine kinase 2 beta

Size: 1009 amino acids; 115875 Da

Subunit: Interacts with Crk-associated substrate (Cas), PTPNS1 and SH2D3C (By similarity).

Interacts with nephrocystin, ASAP2, OPHN1L, SKAP2 and TGFB1I1

Subcellular location: Cytoplasm. Cell membrane. Note=Interaction with nephrocystin induces the

membrane-association of the kinase

PDB structures from and Proteopedia :

2FO6 (3D)

3CC6 (3D)

3FZO (3D)

3FZP (3D)

3FZR (3D)

3FZS (3D)

3FZT (3D)

3GM1 (3D)

3GM2 (3D)

3GM3 (3D)

Secondary accessions: Q13475 Q14290 Q16709

Alternative splicing: 2 isoforms: Q14289-1 Q14289-2

Post-translational modifications:

Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular

calcium concentration, as well as by PKC activation. Recruitment by nephrocystin to cell matrix

adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for

tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and

L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity

(By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_004094.3 NP_775266.1 NP_775267.1 NP_775268.1

ENSEMBL proteins:

ENSP00000342242 ENSP00000380638 ENSP00000380634 ENSP00000332816

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PTK2B
	Millipore Purified and/or Recombinant PTK2B Protein
	Sigma-Aldrich Proteins for PTK2B
	R&D Systems Recombinant & Natural Proteins for PTK2B (PYK2/FAK2)
	Enzo Life Sciences proteins for PTK2B
	Recombinant Proteins from Abcam (PYK2)
	Human Recombinant Proteins from Abnova (PTK2B)

OriGene Purified Recombinant Human Protein: PTK2B

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	7499242
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005925	focal adhesion	IEA	--

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Antibodies for PTK2B:

	Invitrogen Antibodies for PTK2B
	Millipore Mono- and Polyclonal Antibodies for the study of PTK2B
	Sigma-Aldrich Antibody Arrays and Antibodies for PTK2B
	R&D Systems Antibodies for PTK2B (PYK2/FAK2)
	Cell Signaling Technology (CST) Antibodies for PTK2B (Pyk2)
	Antibodies from Abcam (PYK2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PTK2B)
	Novus Biologicals Antibodies for PTK2B

Assays for PTK2B:

	Invitrogen Assays for PTK2B
	Millipore Kits and Assays for the Analysis of PTK2B
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14289

ProtoNet protein and cluster: Q14289

2 Blocks protein families:

IPB005189 Focal adhesion targeting region

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily

Similarity: Contains 1 FERM domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTK2B)
		Millipore RNAi Products for the Analysis of PTK2B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PTK2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004103

Applied Biosystems Silencer® siRNAs for PTK2B

Sigma-Aldrich siRNA and siRNA Panels for PTK2B

Sigma-Aldrich shRNA Panels and shRNA for PTK2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PTK2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004103
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004103
untagged cDNA clones in CMV expression vector (see all 6): NM_004103

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173176

UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289

Function: Involved in calcium induced regulation of ion channel and activation of the map kinase

signaling pathway. May represent an important signaling intermediate between neuropeptide

activated receptors or neurotransmitters that increase calcium flux and the downstream signals

that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the

voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the

stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA

'Tyr-125' phosphorylation

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for PTK2B:

focal adhesion kinase 2

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptk2b):

homeostasis/metabolism

immune system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS	8497321
GO:0004871	signal transducer activity	NAS	10867021
GO:0005515	protein binding	IPI	9020138
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/12 Sigma-Aldrich "Your Favorite Gene" Pathways for PTK2B (Your Favorite Gene powered by Ingenuity) (see all 12 )

ERK/MAPK Signaling
Fc&gamma
IL-15 Production
G-Protein Coupled Receptor Signaling
Cholecystokinin/Gastrin-mediated Signaling

GeneDecks PTK2B for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PTK2B

5/144 Interacting proteins for PTK2B (ENSP00000332816³ Q14289^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 144 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHOU	Q7L0Q8¹	STRING (score=.826) EBI-298640, EBI-1638043
PDCD6IP	Q8WUM4²	STRING (score=.712) MINT-68515
MAP3K4	Q9Y6R4²	MINT-51385 MINT-51384
BCAR1	ENSP00000162330³	STRING (score=.999)
PXN	ENSP00000228307³	STRING (score=.999)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	TAS	10867021
GO:0006468	protein amino acid phosphorylation	TAS	7529876
GO:0006915	apoptosis	TAS	10880513
GO:0006950	response to stress	TAS	8939945
GO:0007165	signal transduction	TAS	7499242 10867021

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PTK2B
10/56 Novoseek chemical compound relationships for PTK2B gene (see all 56 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	92.88	1760	10037772 (9), 10749687 (9), 11739373 (6), 8695788 (6) (see all 99)
phosphotyrosine	73.47	17	11208605 (1), 8920763 (1), 10773618 (1), 18503146 (1) (see all 15)
beta-hydroxyisovalerylshikonin	69.87	16	14551501 (6), 12592388 (2), 12716473 (2)
ag957	68.75	3	9823945 (1), 12380934 (1)
phosphatidylinositol	61.74	51	10797305 (4), 11262415 (2), 10037772 (1), 11694268 (1) (see all 25)
vanadate	61.58	14	7694572 (3), 7535209 (2), 12175337 (1), 9119896 (1) (see all 6)
ginsenoside rd	61.21	2	10763582 (1), 10763583 (1)
bisindolylmaleimide	59.17	6	9028864 (1), 8794869 (1), 9491850 (1), 10210645 (1) (see all 5)
sodium orthovanadate	58.49	3	8842442 (1), 10085098 (1)
daidzein	57.61	10	9918844 (1), 8621613 (1), 16715119 (1), 9521814 (1) (see all 8)

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1 PharmGKB drug compound relationship for PTK2B gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	12911626

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTK2B)
		Millipore RNAi Products for the Analysis of PTK2B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PTK2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004103

Sigma-Aldrich siRNA and siRNA Panels for PTK2B

Sigma-Aldrich shRNA Panels and shRNA for PTK2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004103 NM_173174 NM_173175 NM_173176

REFSEQ mRNAs for PTK2B gene (4 alternative transcripts):

NM_004103.3 NM_173174.1 NM_173175.1 NM_173176.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004103 NM_173174 NM_173175 NM_173176

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004103
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004103
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_004103

Additional cDNA sequence:

AB209085.1 AK128371.1 AY429564.1 BC036651.2 BC042599.2 CR613708.1 D45853.1 L49207.1

U33284.1 U43522.1

15 DOTS entries:

DT.95360491 DT.95226435 DT.100816481 DT.101971785 DT.100035969 DT.100816479 DT.40227837 DT.120647181

DT.120647184 DT.120647207 DT.120647240 DT.91747726 DT.92005520 DT.92043930 DT.97854200

24/232 AceView cDNA sequences (see all 232 ):

BM980790 CR613708 CD369939 AA904030 AI590090 CB156700 BF932497 AA938078

AA322905 NM_173175 NM_004103 AI913993 NM_173176 AA814433 BF986368 CB850679

AA507650 CA446390 NM_173174 AA477775 AA826177 CF137401 BQ009032 BM712234

highest scoring ESTs for PTK2B:

U33284 U43522 AA306646 AA309559 AA464438 AA464439 AA477775 AA477885 AA507517 AA586324

Unigene Cluster for PTK2B:

PTK2B protein tyrosine kinase 2 beta

Hs.491322 [show with all ESTs]

Unigene Representative Sequence: BC036651

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PTK2B (see all 10 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^
SP1:			-		-		-				-		-				-																		-				-
SP2:											-		-				-																		-				-
SP3:
SP4:																	-
SP5:					-		-				-		-				-

ExUns:	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29a	·	29b	^	30	^	31	^	32	^	33	^	34	^	35
SP1:
SP2:
SP3:																	-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PTK2B

4 Ensembl transcripts including schematic representations:

ENST00000338238 ENST00000397501 ENST00000397497 ENST00000346049

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PTK2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PTK2B

¹ / ² / ³

6 probe-sets matching PTK2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2009_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.79	U33284	1.00	0.90	0.95	1
33804_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.22	U43522	1.00	0.90	0.95	1
203111_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004103	0.60	1.00	0.82	1
203110_at²^{, 3}	U133-A	2	1.00	0.95	--	--	U43522	1.00	0.90	0.95	1
203111_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203110_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks PTK2B for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTTTGCATA

SOURCE GeneReport for Unigene cluster: Hs.491322
Expression variation in blood from EXPOLDB for PTK2B
UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
Tissue specificity: Most abundant in the brain, with highest levels in amygdala and hippocampus.
Low levels in kidney. Also expressed in spleen and lymphocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for PTK2B gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PTK2B¹	--	PTK2B protein tyrosine kinase 2 beta	91.05(n) 96.23(a)	486102 XM_543228.2 XP_543228.2
chimpanzee (Pan troglodytes)	PTK2B¹	--	PTK2B protein tyrosine kinase 2 beta	99.47(n) 99.6(a)	464073 XM_519675.2 XP_519675.2
cow (Bos taurus)	PTK2B¹	--	PTK2B protein tyrosine kinase 2 beta	90.88(n) 95.64(a)	541008 XM_614070.3 XP_614070.3
rat (Rattus norvegicus)	Ptk2b¹	--	PTK2B protein tyrosine kinase 2 beta	88.73(n) 95.54(a)	50646 NM_017318.1 NP_059014.1
mouse (Mus musculus)	Ptk2b^{1, 5}	14 (28.00 cM)⁵	PTK2 protein tyrosine kinase 2 beta^{1, 5}	88.9(n)¹ 95.24(a)¹	19229¹ NM_172498.2¹ NP_766086.1¹ AA537970⁵ AI153373⁵ (see all 13)

About this table Species with no ortholog for PTK2B

ENSEMBL Gene Tree for PTK2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PTK2B gene

PTK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/822 NCBI SNPs in PTK2B are shown (see all 822 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 371)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1316370^1,2	A,C,F,H,O	27236982(+)	`GCAACC/TTATGC`	3	--	int¹ ng5¹		16	NS EU EA WA NA	1084
	rs939269^1,2	A,C,F,H,O	27237373(+)	`AACTCA/TCCTTT`	4	--	ng5¹ int¹ trp³		11	NA EU EA WA	920
	rs2241649^1,2	A,C,F,H,O	27310997(+)	`TGCCGA/GTCTTA`	4	--	ut5¹ ese³		12	EA EU WA NA	2442
	rs2271920^1,2	A,C,F,H	27372034(-)	`CCTTCC/TCCCTG`	4	--	ut3¹ ese³ trp³		5	EA EU WA	1902
	rs9693010^1,2	A,C,F,H	27236996(+)	`ATGGAG/CAGCAT`	3	--	ng5¹ int¹		7	EU EA WA NA	560
	rs11993843^1,2	A,C,F,H	27238183(+)	`ATGAGG/AATGAT`	4	--	int¹ ng5¹		9	NA MN EA EU WA	1802
	rs751019^1,2	C,F,H,O	27364502(+)	`TGATAA/CGTCCC`	4	K/T	mis¹ ese³		11	EU EA WA	2136
--	rs9693096^1,2	C,F,H	27237175(+)	`GCCACC/ACCAGA`	4	--	int¹ ng5¹ tfbs³		7	EU EA WA NA	560
--	rs11989506^1,2	C,F,H	27236979(+)	`ATTGCA/CACTTA`	3	--	ng5¹ int¹		4	EU EA WA	402
	rs10095624^1,2	A,C,F	27238193(+)	`TGCTGC/AGTACA`	4	--	int¹ ng5¹		5	NA MN EA	1394

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HapMap Linkage Disequilibrium images for PTK2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601212

10/65 Novoseek disease relationships for PTK2B gene (see all 65 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	47.09	7	9566916 (1), 17605888 (1), 12488463 (1), 15087031 (1) (see all 7)
hypo-osmolality	36.86	5	10811968 (3), 10381589 (2)
leukemia	27.63	13	9569020 (2), 7488237 (1), 11114726 (1), 14636885 (1) (see all 11)
sarcoma avian	25.95	3	8278385 (1), 1309253 (1)
blast crisis	24.71	1	15087031 (1)
tumors	23.87	57	7475883 (4), 8442941 (4), 8179861 (3), 8920763 (2) (see all 32)
glioma	18.04	26	16962067 (4), 15499613 (3), 15967096 (3), 12900387 (2) (see all 11)
necrosis	16.86	12	12515814 (2), 8778024 (1), 10521452 (1), 8739563 (1) (see all 9)
breast cancer	12.11	46	18832579 (5), 10713673 (3), 1380891 (3), 14654952 (3) (see all 16)
erythroleukemia	9.78	1	11748589 (1)

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Human Genome Epidemiology Navigator: PTK2B (2 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/817 PubMed articles for PTK2B gene (see all 817 ):

Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. (PubMed id 7499242)^{1, 2, 3, 4} Avraham S....Groopman J.E. (1995)
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. (PubMed id 7544443)^{1, 2, 3, 4} Lev S.... Schlessinger J. (1995)
A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. (PubMed id 9545257)^{1, 3, 4} Li X.... Earp H.S. (1998)
Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. (PubMed id 11493697)^{1, 3, 4} Benzing T.... Walz G. (2001)
Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. (PubMed id 9422762)^{1, 3, 4} Matsuya M.... Sasaki T. (1998)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)^{3, 4} Nusbaum C....Lander E.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. (PubMed id 12893833)^{3, 4} Takahashi T.... Matsumoto M. (2003)
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)^{3, 4} Salomon A.R.... Peters E.C. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2185	HGNC: 9612	AceView: PTK2B	Ensembl:ENSG00000120899	euGenes: HUgn2185
ECgene: PTK2B	H-InvDB: PTK2B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PTK2B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PTK2B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PTK2B:

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Antibodies & Assays for PTK2B (Pyk2)

	Recombinant Proteins (PYK2)
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Antibodies for PTK2B

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PTK2B Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for PTK2B

Summaries
for PTK2B

Genomic Location
for PTK2B

Proteins
for PTK2B

Protein Domains/
Families
for PTK2B

Gene Function
for PTK2B

Pathways & Interactions
for PTK2B

Drugs & Compounds
for PTK2B

Transcripts
for PTK2B

Expression
for PTK2B

Orthologs
for PTK2B

Paralogs
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SNPs/Variants
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Disorders & Mutations
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Medical News
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Publications
for PTK2B

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Genome Databases showing PTK2B

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PTK2B (Gene Symbol)
CADTK
CAKB
EC 2.7.10.2
FADK2
FAK2
FRNK
OTTHUMP00000128275
OTTHUMP00000162913
PKB
PTK
PYK2
RAFTK
CAK beta
Calcium-dependent tyrosine kinase
Cell adhesion kinase beta
FADK 2
Focal adhesion kinase 2
PTK2B protein tyrosine kinase 2 beta
Proline-rich tyrosine kinase 2
Related adhesion focal tyrosine kinase
protein kinase B
protein tyrosine kinase 2 beta

PTK2B Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor PTK2B

Summariesfor PTK2B

Genomic Locationfor PTK2B

Proteinsfor PTK2B

Protein Domains/Familiesfor PTK2B

Gene Functionfor PTK2B

Pathways & Interactionsfor PTK2B

Drugs & Compoundsfor PTK2B

Transcriptsfor PTK2B

Expression for PTK2B

Orthologsfor PTK2B

Paralogsfor PTK2B

SNPs/Variantsfor PTK2B

Disorders & Mutationsfor PTK2B

Medical Newsfor PTK2B

Publicationsfor PTK2B

Search for PTK2B

Genome Databases showing PTK2B

Other Databases showing PTK2B

Specialized Databases showing PTK2B

Licensable Technologiesfor PTK2B

Servicesfor PTK2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PTK2B

Summaries
for PTK2B

Genomic Location
for PTK2B

Proteins
for PTK2B

Protein Domains/
Families
for PTK2B

Gene Function
for PTK2B

Pathways & Interactions
for PTK2B

Drugs & Compounds
for PTK2B

Transcripts
for PTK2B

Expression
for PTK2B

Orthologs
for PTK2B

Paralogs
for PTK2B

SNPs/Variants
for PTK2B

Disorders & Mutations
for PTK2B

Medical News
for PTK2B

Publications
for PTK2B

Licensable Technologies
for PTK2B

Services
for PTK2B