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PTK2B Gene

protein-coding   GIFtS: 73
GCID: GC08P027224

Protein Tyrosine Kinase 2 Beta

(Previous names: protein tyrosine kinase 2 beta, PTK2B protein tyrosine kinase...)
(Previous symbol: FAK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Kinase 2 Beta1 2     CAK-beta2 3
FAK21 2 3 5     CAKB2 3
PYK22 3 5     RAFTK2 3
PTK2B Protein Tyrosine Kinase 2 Beta1 2     FADK 22 3
Calcium-Dependent Tyrosine Kinase2 3     EC 2.7.10.23 8
Calcium-Regulated Non-Receptor Proline-Rich Tyrosine Kinase2 3     FADK22
Cell Adhesion Kinase Beta2 3     PKB2
Focal Adhesion Kinase 22 3     PTK2
Proline-Rich Tyrosine Kinase 22 3     Protein Kinase B2
Related Adhesion Focal Tyrosine Kinase2 3     Protein-Tyrosine Kinase 2-Beta2
CADTK2 3     EC 2.7.108

External Ids:    HGNC: 96121   Entrez Gene: 21852   Ensembl: ENSG000001208997   OMIM: 6012125   UniProtKB: Q142893   

Export aliases for PTK2B gene to outside databases

Previous GC identifers: GC08P027003 GC08P027685 GC08P027190 GC08P025714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTK2B Gene:
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion
channels and activation of the map kinase signaling pathway. The encoded protein may represent an important
signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux
and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine
phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic
acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been
shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of
GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant
sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTK2B Gene:
PTK2B (protein tyrosine kinase 2 beta) is a protein-coding gene. Diseases associated with PTK2B include cd45 deficiency, and gallbladder adenocarcinoma. GO annotations related to this gene include protein tyrosine kinase activity and signal transducer activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
Function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell
polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the
humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration
of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation.
Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell
responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit
differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen
receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors,
and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members
upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for
scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of
phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates
production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including
activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and
RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity,
P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby
allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA
receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity
and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium
channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and
SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2

Gene Wiki entry for PTK2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTK2B gene promoter:
         STAT1   NRSF form 1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PTK2B promoter sequence
   Search Chromatin IP Primers for PTK2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTK2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.1

PTK2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTK2B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P027224:  view genomic region     (about GC identifiers)

Start:
27,168,999 bp from pter      End:
27,316,908 bp from pter
Size:
147,910 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289 (See protein sequence)
Recommended Name: Protein-tyrosine kinase 2-beta  
Size: 1009 amino acids; 115875 Da
Subunit: Homodimer, or homooligomer. Interacts with SIRPA and SH2D3C. Interacts with ARHGAP10. Interacts with DLG4
(By similarity). Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form
interacts with SRC (via SH2 domain) and SRC family members. Forms a signaling complex with EPHA1, LCK and
phosphatidylinositol 3-kinase; upon activation by EFNA1. Interacts with GRB2 (via SH2 domain). Interacts with
P53/TP53 and MDM2. Interacts with MYLK. Interacts with BCAR1. Interacts with PDPK1. Interacts
(hypophosphorylated) with PXN. Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1. Interacts with
LPXN and PTPN12
Miscellaneous: Promotes bone resorption, and thus PTK2B/PYK2 inhibitors might be used to treat osteoporosis
Selected PDB 3D structures from and Proteopedia for PTK2B (see all 18):
2FO6 (3D)        2LK4 (3D)        3CC6 (3D)        3ET7 (3D)        3FZO (3D)        3FZP (3D)    
Secondary accessions: D3DST0 Q13475 Q14290 Q16709 Q6PID4
Alternative splicing: 2 isoforms:  Q14289-1   Q14289-2   

Explore the universe of human proteins at neXtProt for PTK2B: NX_Q14289

Explore proteomics data for PTK2B at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium
    concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS).
    Tyr-402 is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402.
    Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on
    the other subunit. Phosphorylation at Tyr-402 promotes interaction with SRC and SRC family members, leading to
    phosphorylation at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is important for interaction with
    GRB2. Phosphorylated on tyrosine residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell matrix
    adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine
    phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also
    induce autophosphorylation and increase kinase activity. Phosphorylation by MYLK promotes ITGB2 activation and is
    thus essential to trigger neutrophil transmigration during lung injury. Dephosphorylated by PTPN121
  • Ubiquitination2 at Lys188, Lys944
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTK2B (Q14289) (see all 6)
     RLPIKWM  VCMWEIL  PTANLDR  PESINFRRFT 


    See PTK2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_004094.3  NP_775266.1  NP_775267.1  NP_775268.1  

    ENSEMBL proteins: 
     ENSP00000380638   ENSP00000429694   ENSP00000430404   ENSP00000332816   ENSP00000428271  
     ENSP00000416174   ENSP00000427931   ENSP00000428837   ENSP00000380634   ENSP00000342242  
     ENSP00000440926   ENSP00000391995  
    Reactome Protein details: Q14289

    PTK2B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PTK2B Protein
    R&D Systems Recombinant & Natural Proteins for PTK2B (PYK2/FAK2)
    Enzo Life Sciences proteins for PTK2B
    OriGene Purified Proteins for PTK2B
    OriGene Protein Over-expression Lysate for PTK2B
    OriGene MassSpec for PTK2B
    OriGene Custom Protein Services for PTK2B
    GenScript Custom Purified and Recombinant Proteins Services for PTK2B
    Novus Biologicals PTK2B Proteins
    Novus Biologicals PTK2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PTK2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTK2B
    R&D Systems Antibodies for PTK2B (PYK2/FAK2)
    Cell Signaling Technology (CST) Antibodies for PTK2B  (Pyk2)
    OriGene Antibodies for PTK2B
    OriGene Custom Antibody Services for PTK2B
    Novus Biologicals PTK2B Antibodies
    Abcam antibodies for PTK2B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PTK2B
    LSBio Antibodies in human, mouse, rat for PTK2B

    PTK2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTK2B
    R&D Systems Proteome Profiler Antibody Arrays for PTK2B (PYK2/FAK2)
    GenScript Custom Assay Services for PTK2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PTK2B protein tyrosine kinase 2 beta
    Fak family

    Selected InterPro protein domains (see all 11):
     IPR019748 FERM_central
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR005189 Focal_adhesion_kin_target_dom

    Graphical View of Domain Structure for InterPro Entry Q14289

    ProtoNet protein and cluster: Q14289

    2 Blocks protein domains:
    IPB005189 Focal adhesion targeting region
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 protein kinase domain


    PTK2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAK2_HUMAN, Q14289
    Function: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell
    polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the
    humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration
    of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation.
    Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell
    responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit
    differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen
    receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors,
    and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members
    upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for
    scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of
    phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates
    production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including
    activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and
    RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity,
    P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby
    allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA
    receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity
    and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium
    channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and
    SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated in response to stimuli that lead to increased intracellular Ca(2+) levels; this
    activation is indirect and may be mediated by calcium-mediated production of reactive oxygen species (ROS).
    Activated by autophosphorylation at Tyr-402; this creates a binding site for SRC family kinases and leads to
    phosphorylation at additional tyrosine residues. Phosphorylation at Tyr-402, Tyr-579 and Tyr-580 is required for
    optimal kinase activity. Inhibited by PF-562,271, BIRB796, PF-4618433 and by PF-431396, PF-2318841 and their
    derivatives. Inhibited by sulfoximine-substituted trifluoromethylpyrimidines. Inhibited by 4-amino and 5-aryl
    substituted pyridinone compounds

         Genatlas biochemistry entry for PTK2B:
    focal adhesion kinase 2

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS8939945
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA7544443
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI10521452
         
    PTK2B for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PTK2B:
     Decreased Salmonella enterica   Decreased substrate adherent c  Decreased viability in CMK cel  Decreased viability of wild-ty 
     Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptk2b):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     muscle 

    PTK2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTK2B: Ptk2btm1Okig Ptk2btm1Schl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTK2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTK2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTK2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTK2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTK2B:
    hsa-mir-23b-3p (MIRT006963), hsa-mir-335-5p (MIRT018928)

    Block miRNA regulation of human, mouse, rat PTK2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTK2B (see all 21):
    hsa-miR-4272 hsa-miR-517a hsa-miR-517c hsa-miR-517b hsa-miR-1184 hsa-miR-330-3p hsa-miR-3121-3p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPTK2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTK2B
    Predesigned siRNA for gene silencing in human, mouse, rat PTK2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTK2B

    Clone
    Products:
         
    OriGene clones in human, mouse for PTK2B (see all 26)
    OriGene ORF clones in mouse, rat for PTK2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK2B (NM_173174)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK2B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTK2B
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTK2B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAK2_HUMAN, Q14289: Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein;
    Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus.
    Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the
    cell periphery
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----

    PTK2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTK2B About   (see all 71)  
    See pathways by source

    SuperPathContained pathways About
    1Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    2IL2-mediated signaling events
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Development Angiotensin activation of ERK
    Development Angiotensin activation of ERK0.74
    Development Angiotensin signaling via PYK20.67
    Development ACM2 and ACM4 activation of ERK0.74
    Development G Proteins mediated regulation MARK ERK signaling0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTK2B (see all 44)
        RhoA Pathway
    Fc-GammaR Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling

    2 Cell Signaling Technology (CST) Pathways for PTK2B
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for PTK2B (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development Angiotensin signaling via PYK2
    Chemotaxis CXCR4 signaling pathway

    Selected BioSystems Pathways for PTK2B (see all 22)
        EGFR1 Signaling Pathway
    Oncostatin M Signaling Pathway
    BDNF signaling pathway
    IL-5 Signaling Pathway
    TCR Signaling Pathway

    2 Reactome Pathways for PTK2B
        Signal regulatory protein (SIRP) family interactions
    Interleukin-2 signaling


    Selected Kegg Pathways  (Kegg details for PTK2B) (see all 6):
        Calcium signaling pathway
    Chemokine signaling pathway
    Natural killer cell mediated cytotoxicity
    Leukocyte transendothelial migration
    GnRH signaling pathway


    PTK2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTK2B: 
              HIV Host Response in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Osmotic Stress in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTK2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTK2B (Q142891, 2, 3 ENSP000003328164) via UniProtKB, MINT, STRING, and/or I2D (see all 137)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K4Q9Y6R42, 3, ENSP000003759864MINT-51385 MINT-51384 I2D: score=3 STRING: ENSP00000375986
    GRB2P629932, 3, ENSP000003390074MINT-8037043 I2D: score=5 STRING: ENSP00000339007
    MATKP426792, 3MINT-8037577 MINT-8037562 I2D: score=3 
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-68515 I2D: score=2 STRING: ENSP00000307387
    SRCP129311, 2, 3, ENSP000003509414EBI-298640,EBI-621482 MINT-8037547 MINT-8037487 MINT-8037502 I2D: score=6 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 84):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0000302response to reactive oxygen species ----
    GO:0001525angiogenesis ----
    GO:0001556oocyte maturation IEA--
    GO:0001666response to hypoxia IEA--

    PTK2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTK2B (FAK2)

    Selected HMDB Compounds for PTK2B (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----

    3 DrugBank Compounds for PTK2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LeflunomideLeflunomidum [INN-Latin] (see all 2)75706-12-6targetantagonist17103252 19149483 17604599
    Genistein4',5, 7-Trihydroxyisoflavone (see all 4)446-72-0target--17139284 17016423
    4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PTK2B gene (see all 145)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 92.8 1858 10037772 (9), 10749687 (9), 11739373 (6), 8695788 (6) (see all 99)
    herbimycin a 90.3 100 9028864 (2), 7691610 (2), 16696126 (2), 8392438 (2) (see all 83)
    genistein 88.9 249 9667736 (4), 8442770 (3), 8891338 (3), 18718176 (2) (see all 99)
    erbstatin 78.2 16 14515350 (1), 9248222 (1), 7852849 (1), 10773618 (1) (see all 9)
    phosphotyrosine 73.1 17 11208605 (1), 8920763 (1), 10773618 (1), 18503146 (1) (see all 15)
    beta-hydroxyisovalerylshikonin 70 16 14551501 (6), 12592388 (2), 12716473 (2)
    ag 1478 68.3 4 9722539 (1), 18667434 (1), 18182168 (1), 19946718 (1)
    ag957 68.3 3 9823945 (1), 12380934 (1)
    ag 213 68.2 2 1375248 (1)
    ag 18 67.1 3 12634073 (1), 19251944 (1), 11467832 (1)



    PTK2B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for PTK2B gene (4 alternative transcripts): 
    NM_004103.4  NM_173174.2  NM_173175.2  NM_173176.2  

    Unigene Cluster for PTK2B:

    Protein tyrosine kinase 2 beta
    Hs.491322  [show with all ESTs]
    Unigene Representative Sequence: NM_173174
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000397501(uc003xfn.2) ENST00000519650 ENST00000522338 ENST00000521164
    ENST00000346049(uc003xfp.2) ENST00000522517 ENST00000412793 ENST00000496920
    ENST00000517339(uc010luq.1) ENST00000521000 ENST00000519512 ENST00000397497(uc003xfr.1 uc003xfs.1)
    ENST00000461615 ENST00000495097 ENST00000482543 ENST00000522245 ENST00000338238
    ENST00000544172(uc022ate.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTK2B (see all 21):
    hsa-miR-4272 hsa-miR-517a hsa-miR-517c hsa-miR-517b hsa-miR-1184 hsa-miR-330-3p hsa-miR-3121-3p hsa-miR-23a
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      QuantiFast Probe-based Assays in human, mouse, rat PTK2B

    Additional mRNA sequence: 

    AB209085.1 AK128371.1 AY429564.1 BC036651.2 BC042599.2 D45853.1 L49207.1 U33284.1 
    U43522.1 

    14 DOTS entries:

    DT.95360491  DT.95226435  DT.100816481  DT.100035969  DT.101971785  DT.100816479  DT.40227837  DT.120647184 
    DT.120647207  DT.91747726  DT.92005520  DT.97854200  DT.120647181  DT.92043930 

    Selected AceView cDNA sequences (see all 232):

    CD369939 AA938078 AA464439 BM980790 CA449933 AA904030 AI913993 AA814433 
    BF986368 BQ009032 R85257 NM_004103 AY429564 CB850679 AA826177 NM_173176 
    CF137401 CR613708 NM_173174 BM699944 CB156700 CA446390 BM712234 AA507650 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTK2B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:        -     -     -           -     -           -                                                     -           -                                       
    SP2:                                -     -           -                                                     -           -                                       
    SP3:                                                                                                                                                            
    SP4:                                                  -                                                                                                         
    SP5:              -     -           -     -           -                                                                                                         

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                                  -                                                   
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PTK2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTK2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGCATA
    PTK2B Expression
    About this image


    PTK2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    PTK2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTK2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491322

    UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
    Tissue specificity: Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in
    kidney (at protein level). Also expressed in spleen and lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTK2B: 
              HIV Host Response in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Osmotic Stress in human mouse rat
              Cell Motility in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTK2B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptk2b1 , 5 PTK2 protein tyrosine kinase 2 beta1, 5 88.97(n)1
    95.24(a)1
      14 (34.36 cM)5
    192291  NM_001162366.11  NP_001155838.11 
     661532575 
    chicken
    (Gallus gallus)
    Aves PTK2B1 PTK2B protein tyrosine kinase 2 beta 78.79(n)
    79.63(a)
      421998  XM_004935843.1  XP_004935900.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTK2B6
    protein tyrosine kinase 2 beta
    72(a)
    1 ↔ 1
    GL343696.1(207535-265559)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptk2b1 protein tyrosine kinase 2 beta 73.42(n)
    76.89(a)
      496459  NM_001011049.1  NP_001011049.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ490510.22   -- 73.7(n)   245950  AJ490510.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fak56D3 cytoskeletal anchoring protein tyrosine
    kinase
    31(a)   56D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea kin-323 protein kinase 30(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for PTK2B (if available)
    TreeFam Gene Tree for PTK2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTK2B gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  PTK22  ERBB22  ZAP702  EGFR2  
    Selected SIMAP similar genes for PTK2B using alignment to 7 protein entries:     FAK2_HUMAN (see all proteins) (see all similar genes):
    ABL1    EPHA2    FES    tec    PTK2    BTK kinase deficient isoform 6
    DKFZp666O0110    HCK    DKFZp686M05208    DKFZp434L0319    ERBB4    CSK
    FGR    BTK kinase deficient isoform 2    FGFR1    MET    NEK6    SRC

    PTK2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTK2B (see all 3445)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012742821,2
    Cuntested127530920(+) TGAATC/TGTATT 8 R C mis10--------
    rs586336441,2
    C--25747511(+) CACTT-/G/TGGGAG 4 -- int10--------
    rs58903671,2
    C--25749796(+) ctact-/AAaaaaa 4 -- int1 trp30--------
    rs1119307591,2
    C--25752961(+) CCCAGC/GCAGGC 4 -- int10--------
    rs1836301041,2
    --25753586(+) ATATAA/TATATA 4 -- int10--------
    rs106403861,2
    C--25756128(+) CTCTA-/ACACACA 4 -- int10--------
    rs1423641691,2
    C--25790384(+) AAGGC-/TTTTTT 4 -- int10--------
    rs112676271,2
    C--25800416(+) GCTGA-/GCAGCTCT
    CCTGCAGCCTC
    GCAGC
    4 -- int10--------
    rs1454282781,2
    C--25800426(+) TCTCC-/TGCAGCCT
    CGCAGCTCTCC
    CATAT
    4 -- int10--------
    rs1489843041,2
    C--25803705(+) TCAAA-/AAAC  
            
    AAACA
    4 -- int10--------

    HapMap Linkage Disequilibrium report for PTK2B (27168999 - 27316908 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PTK2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2092173CNV Deletion18987734
    esv2673904CNV Deletion23128226
    esv2676555CNV Deletion23128226
    esv2430348CNV Insertion19546169
    nsv471719CNV Loss16327809
    nsv890695CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTK2B
    DNA2.0 Custom Variant and Variant Library Synthesis for PTK2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601212    OMIM disorders: --

    UniProtKB/Swiss-Prot: FAK2_HUMAN, Q14289
  • Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion,
    in tumor formation and metastasis. Elevated PTK2B/PYK2 expression is seen in gliomas, hepatocellular carcinoma,
    lung cancer and breast cancer

  • Selected diseases for PTK2B (see all 86):    
    About MalaCards
    cd45 deficiency    gallbladder adenocarcinoma    gangliosidosis    crescentic glomerulonephritis
    transient cerebral ischemia    ischemia    agammaglobulinemia    hypertrophic scars
    myeloproliferative disorder    brain ischemia    retinal degeneration    cholera
    dental caries    traumatic brain injury    adenoid cystic carcinoma    osteoporosis
    adenoiditis    brain injury    malignant glioma    papillary carcinoma

    1 disease from the University of Copenhagen DISEASES database for PTK2B:
    Gangliosidosis

    PTK2B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PTK2B gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 45.6 7 9566916 (1), 17605888 (1), 12488463 (1), 15087031 (1) (see all 7)
    hypo-osmolality 35.8 5 10811968 (3), 10381589 (2)
    leukemia 27 14 9569020 (2), 7488237 (1), 11114726 (1), 14636885 (1) (see all 12)
    tumors 25.2 61 7475883 (4), 8442941 (4), 8179861 (3), 20074345 (3) (see all 34)
    sarcoma avian 24.6 3 8278385 (1), 1309253 (1)
    blast crisis 23.2 1 15087031 (1)
    glioma 22.2 36 16962067 (4), 15499613 (3), 15967096 (3), 12900387 (2) (see all 14)
    necrosis 14.7 12 12515814 (2), 8778024 (1), 10521452 (1), 8739563 (1) (see all 9)
    cholera 11 1 9028864 (1)
    breast cancer 10.6 47 18832579 (5), 10713673 (3), 1380891 (3), 14654952 (3) (see all 17)

    Genetic Association Database (GAD): PTK2B
    Human Genome Epidemiology (HuGE) Navigator: PTK2B (12 documents)

    Export disorders for PTK2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTK2B gene, integrated from 10 sources (see all 1056):
    (articles sorted by number of sources associating them with PTK2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. (PubMed id 7499242)1, 2, 3, 9 Avraham S.... Avraham H. (J. Biol. Chem. 1995)
    2. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. (PubMed id 7544443)1, 2, 3, 9 Lev S.... Schlessinger J. (Nature 1995)
    3. Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. (PubMed id 19880522)1, 2, 9 Lim S.T.... Schlaepfer D.D. (J. Biol. Chem. 2010)
    4. Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation. (PubMed id 18765415)1, 2, 9 Sun C.K.... Fan S.T. (Carcinogenesis 2008)
    5. Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. (PubMed id 19086031)1, 2, 9 Rufanova V.A.... Sorokin A. (J. Cell. Physiol. 2009)
    6. A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. (PubMed id 9545257)1, 2, 9 Li X.... Earp H.S. (J. Biol. Chem. 1998)
    7. T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells. (PubMed id 20381867)1, 2, 9 Collins M.... Houtman J.C. (Mol. Immunol. 2010)
    8. Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. (PubMed id 11493697)1, 2, 9 Benzing T.... Walz G. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation. (PubMed id 19207108)1, 2, 9 Gao C. and Blystone S.D. (Biochem. J. 2009)
    10. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PubMed id 17329398)1, 2, 9 Sahu S.N.... Gupta A. (Am. J. Physiol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2185 HGNC: 9612 AceView: PTK2B Ensembl:ENSG00000120899 euGenes: HUgn2185
    ECgene: PTK2B Kegg: 2185 H-InvDB: PTK2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTK2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTK2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTK2B gene:
    Search GeneIP for patents involving PTK2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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