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PTK2 Gene

protein-coding   GIFtS: 73
GCID: GC08M141667

Protein Tyrosine Kinase 2

(Previous name: PTK2 protein tyrosine kinase 2)
  See PTK2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Tyrosine Kinase 21 2     pp125FAK2 3
PTK2 Protein Tyrosine Kinase 21 2     EC 2.7.10.23 8
Focal Adhesion Kinase-Related Nonkinase2 3     FADK2 5
Protein Phosphatase 1 Regulatory Subunit 712 3     Protein Phosphatase 11
FAK2 3     Regulatory Subunit 711
FAK12 3     FAK-Related Non-Kinase Polypeptide2
FRNK2 3     Focal Adhesion Kinase 12
PPP1R712 3     Protein Phosphatase 1, Regulatory Subunit 712
FADK 12 3     Protein-Tyrosine Kinase 23
p125FAK2 3     EC 2.7.108

External Ids:    HGNC: 96111   Entrez Gene: 57472   Ensembl: ENSG000001693987   OMIM: 6007585   UniProtKB: Q053973   

Export aliases for PTK2 gene to outside databases

Previous GC identifers: GC08M140557 GC08M141856 GC08M141352 GC08M141639 GC08M141737 GC08M136979


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTK2 Gene:
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that
form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member
of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other
subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal
transduction pathways triggered in response to certain neural peptides or to cell interactions with the
extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but
the full-length natures of only three of them have been determined. (provided by RefSeq, Dec 2010)

GeneCards Summary for PTK2 Gene:
PTK2 (protein tyrosine kinase 2) is a protein-coding gene. Diseases associated with PTK2 include scar contracture, and askin's tumor. GO annotations related to this gene include actin binding and signal transducer activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
Function: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration,
adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and
cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic
development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and
proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching
and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and
differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of
numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors.
Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the
phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and
substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the
AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade.
Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating
proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members
mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates
P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC
kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1;
most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated
PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both
SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain
and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear
accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription

summary for PTK2 Gene:
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal
transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known
as focal adhesions. Therefore, FAK is plays a key role in cellular migration and motility. FAK has 3
functional domains: a focal adhesion targeting domain (FAT), a catalytic domain and a FERM domain, which
mediates interactions with the cytoplasmic domains of integrins and growth factor receptors. FAK has
multiple phosphorylation sites that are required for binding to adaptor proteins containing SH2 domains
(e.g. Src and SH3 domains (e.g. CAS, GRAF)). Key amongst these phosphorylation sites is Tyr397, which is
important for the interaction of FAK with downstream signaling molecules such as PI 3-K, PLCgamma and Rho
kinase. Overexpression of FAK has been associated with several types of cancer.

Gene Wiki entry for PTK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTK2 gene promoter:
         SRF   CREB   AP-1   SRF (504 AA)   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTK2 promoter sequence
   Search Chromatin IP Primers for PTK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

PTK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTK2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M141667:  view genomic region     (about GC identifiers)

Start:
141,667,999 bp from pter      End:
142,012,315 bp from pter
Size:
344,317 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397 (See protein sequence)
Recommended Name: Focal adhesion kinase 1  
Size: 1052 amino acids; 119233 Da
Subunit: Interacts (via first Pro-rich region) with CAS family members (via SH3 domain), including BCAR1, BCAR3,
CASS4 and NEDD9. Interacts with GIT1. Interacts with SORBS1. Interacts with ARHGEF28. Interacts with SHB.
Interacts with PXN and TLN1. Interacts with STAT1. Interacts with DCC. Interacts with WASL. Interacts with
ARHGEF7. Interacts with GRB2 and GRB7 (By similarity). Component of a complex that contains at least FER, CTTN
and PTK2/FAK1. Interacts with BMX. Interacts with TGFB1I1. Interacts with STEAP4. Interacts with ZFYVE21.
Interacts with ESR1. Interacts with PIK3R1 or PIK3R2. Interacts with SRC, FGR, FLT4 and RET. Interacts with EPHA2
in resting cells; activation of EPHA2 recruits PTPN11, leading to dephosphorylation of PTK2/FAK1 and dissociation
of the complex. Interacts with EPHA1 (kinase activity-dependent). Interacts with CD4; this interaction requires
the presence of HIV-1 gp120. Interacts with PIAS1. Interacts with ARHGAP26 and SHC1. Interacts with RB1CC1; this
inhibits PTK2/FAK1 activity and activation of downstream signaling pathways. Interacts with P53/TP53 and MDM2.
Interacts with LPXN (via LD motif 3). Interacts with MISP. Interacts with CIB1 isoform 2
Developmental stage: Isoform 6 is detected in cultured cells, immediately after seeding and before formation of
focal adhesions (at protein level)
Selected PDB 3D structures from and Proteopedia for PTK2 (see all 23):
1K04 (3D)        1K05 (3D)        1MP8 (3D)        1OW6 (3D)        1OW7 (3D)        1OW8 (3D)    
Secondary accessions: B4E2N6 F5H4S4 Q14291 Q9UD85
Alternative promoter usage, Alternative splicing: 6 isoforms:  Q05397-1   Q05397-2   Q05397-3   Q05397-4   Q05397-5   Q05397-6   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for PTK2: NX_Q05397

Explore proteomics data for PTK2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues upon activation, e.g. upon integrin signaling. Tyr-397 is the major
    autophosphorylation site, but other kinases can also phosphorylate this residue. Phosphorylation at Tyr-397
    promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-576, Tyr-577 and at
    additional tyrosine residues. FGR promotes phosphorylation at Tyr-397 and Tyr-576. FER promotes phosphorylation
    at Tyr-577, Tyr-861 and Tyr-925, even when cells are not adherent. Tyr-397, Tyr-576 and Ser-722 are
    phosphorylated only when cells are adherent. Phosphorylation at Tyr-397 is important for interaction with BMX,
    PIK3R1 and SHC1. Phosphorylation at Tyr-925 is important for interaction with GRB2. Dephosphorylated by PTPN11;
    PTPN11 is recruited to PTK2 via EPHA2 (tyrosine phosphorylated). Microtubule-induced dephosphorylation at Tyr-397
    is crucial for the induction of focal adhesion disassembly; this dephosphorylation could be catalyzed by PTPN11
    and regulated by ZFYVE211
  • Sumoylated; this enhances autophosphorylation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTK2 (Q05397) (see all 24)
     VCMWEIL  PTANLDR  AARNVLV  SEEVHWLH 


    See PTK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186578.1  NP_005598.3  NP_722560.1  

    ENSEMBL proteins: 
     ENSP00000429911   ENSP00000429929   ENSP00000429170   ENSP00000429082   ENSP00000429474  
     ENSP00000430916   ENSP00000428492   ENSP00000341189   ENSP00000428570   ENSP00000429129  
     ENSP00000429023   ENSP00000403416   ENSP00000430603   ENSP00000430828   ENSP00000429437  
     ENSP00000427774   ENSP00000431106   ENSP00000427972   ENSP00000429702   ENSP00000428593  
     ENSP00000429958   ENSP00000428482   ENSP00000428380   ENSP00000428232   ENSP00000429001  
     ENSP00000427825   ENSP00000429895   ENSP00000427762   ENSP00000428792   ENSP00000430277  
     ENSP00000427904   ENSP00000429530   ENSP00000427795   ENSP00000430951   ENSP00000430044  
     ENSP00000429907   ENSP00000429409   ENSP00000430037   ENSP00000429028   ENSP00000431023  
     ENSP00000438009   ENSP00000378644   ENSP00000445742  
    Reactome Protein details: Q05397

    PTK2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PTK2 Protein
    R&D Systems Recombinant & Natural Proteins for PTK2 (FAK)
    Enzo Life Sciences proteins for PTK2
    OriGene Purified Proteins for PTK2
    OriGene Protein Over-expression Lysate for PTK2
    OriGene MassSpec for PTK2
    OriGene Custom Protein Services for PTK2
    GenScript Custom Purified and Recombinant Proteins Services for PTK2
    Novus Biologicals PTK2 Proteins
    Novus Biologicals PTK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PTK2 

     
    antibodies-online proteins for PTK2 (5 products) 

     
    antibodies-online peptides for PTK2

    PTK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTK2
    R&D Systems Antibodies for PTK2 (FAK)
    Cell Signaling Technology (CST) Antibodies for PTK2  (FAK)
    OriGene Antibodies for PTK2
    OriGene Custom Antibody Services for PTK2
    Novus Biologicals PTK2 Antibodies
    Abcam antibodies for PTK2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PTK2
    LSBio Antibodies in human, mouse, rat for PTK2
    antibodies-online antibodies for PTK2 (577 products) 

    PTK2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of PTK2
    OriGene Custom Assay Services for PTK2
    R&D Systems ELISAs for PTK2 (FAK)         (see all)
    GenScript Custom Assay Services for PTK2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PTK2 
    antibodies-online kits for PTK2 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    IUPHAR Guide to PHARMACOLOGY protein family classification: PTK2 protein tyrosine kinase 2
    Fak family

    Selected InterPro protein domains (see all 10):
     IPR019748 FERM_central
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR005189 Focal_adhesion_kin_target_dom

    Graphical View of Domain Structure for InterPro Entry Q05397

    ProtoNet protein and cluster: Q05397

    2 Blocks protein domains:
    IPB005189 Focal adhesion targeting region
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
    Domain: The Pro-rich regions interact with the SH3 domain of CAS family members, such as BCAR1 and NEDD9, and with
    the GTPase activating protein ARHGAP26
    Domain: The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the
    localization of FAK1 to focal adhesions
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PTK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAK1_HUMAN, Q05397
    Function: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration,
    adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and
    cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic
    development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and
    proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching
    and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and
    differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of
    numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors.
    Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the
    phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and
    substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the
    AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade.
    Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating
    proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members
    mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates
    P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC
    kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1;
    most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated
    PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both
    SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain
    and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear
    accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Subject to autoinhibition, mediated by interactions between the FERM domain and the kinase
    domain. Activated by autophosphorylation at Tyr-397. This promotes interaction with SRC and phosphorylation at
    Tyr-576 and Tyr-577 in the kinase activation loop. Phosphorylation at Tyr-576 and Tyr-577 is required for maximal
    kinase activity. Inhibited by TAC544, TAE226, PF-573,228 and PF-562,271

         Genatlas biochemistry entry for PTK2:
    focal adhesion kinase 1,pp125FAK,widely expressed in T and B lymphocytes,with a splice variant,FAK1A,expressed in
    brain,primary mediator of integrin signaling after integrin mediated cell adhesion and FAK phosphorylation,also
    mediating a direct interaction with the C terminal SH2 domain of phospholipase C (PCLG1)

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA16803572
    GO:0004672protein kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA10655584
    GO:0004871signal transducer activity IEA--
         
    Find genes that share ontologies with PTK2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PTK2:
     Decreased substrate adherent c  Decreased viability in HMC1.1   Decreased viability with pacli  Increased circadian period len 
     Synthetic lethal with c-Myc af 

         Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Ptk2) (see all 20):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with PTK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTK2: Ptk2tm1Ilic Ptk2tm1Imeg Ptk2tm1.1Jtpa Ptk2tm1.2Guan

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTK2

    miRNA
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    miRTarBase miRNAs that target PTK2:
    hsa-mir-138-5p (MIRT006388), hsa-mir-193a-3p (MIRT004001), hsa-mir-7-5p (MIRT006900), hsa-let-7e-5p (MIRT051491), hsa-mir-21-5p (MIRT030918), hsa-let-7c-5p (MIRT051867)

    Block miRNA regulation of human, mouse, rat PTK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTK2 (see all 23):
    hsa-miR-4251 hsa-let-7a-2* hsa-miR-340 hsa-miR-410 hsa-miR-548a-3p hsa-miR-633 hsa-let-7g* hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidPTK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTK2

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    OriGene ORF clones in mouse, rat for PTK2
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    GenScript: all cDNA clones in your preferred vector (see all 4): PTK2 (NM_173174)
    Sino Biological Human cDNA Clone for PTK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK2
    Addgene plasmids for PTK2 

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    eBioscience FlowRNA Probe Sets ( VA1-12094) for PTK2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAK1_HUMAN, Q05397: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
    Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome (By similarity). Nucleus. Note=Constituent of focal adhesions. Detected at microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    nucleus5
    plasma membrane5
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15855171
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PTK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTK2 About   (see all 78)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    2EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    3Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Cytoskeleton remodeling Slit Robo signaling0.92
    4Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    5Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39


    Find genes that share SuperPaths with PTK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PTK2
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTK2 (see all 40)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for PTK2
        Tyrosine Kinases / Adaptors
    Adhesion

    3 Tocris Bioscience Pathways for PTK2
        Akt Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PTK2 (see all 16)
        Development VEGF signaling via VEGFR2 - generic cascades
    Cell adhesion Integrin inside-out signaling
    Development EGFR signaling pathway
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility

    Selected BioSystems Pathways for PTK2 (see all 18)
        Angiogenesis
    Focal Adhesion
    Integrin-mediated cell adhesion
    ErbB signaling pathway
    Androgen receptor signaling pathway


    Selected Reactome Pathways for PTK2 (see all 9)
        NCAM signaling for neurite out-growth
    p130Cas linkage to MAPK signaling for integrins
    GRB2:SOS provides linkage to MAPK signaling for Integrins
    Netrin mediated repulsion signals
    Signal regulatory protein (SIRP) family interactions


    Selected Kegg Pathways  (Kegg details for PTK2) (see all 14):
        ErbB signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Axon guidance
    VEGF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTK2 (see all 12): 
              Lymphoma in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTK2 (Q053971, 2, 3 ENSP000003411894) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCAR1P569451, 2, 3, ENSP000001623304EBI-702142,EBI-702093 MINT-74938 I2D: score=9 STRING: ENSP00000162330
    TP53P046371, 2, 3, ENSP000002693054EBI-702142,EBI-366083 MINT-7294020 I2D: score=4 STRING: ENSP00000269305
    GRB2P629932, 3, ENSP000003390074MINT-8036897 MINT-8256602 I2D: score=7 STRING: ENSP00000339007
    DDX39AO001482, 3, ENSP000002427764MINT-8267513 I2D: score=2 STRING: ENSP00000242776
    EPHA2P293171, 3, ENSP000003512094EBI-702142,EBI-702104 I2D: score=2 STRING: ENSP00000351209
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 69):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0001525angiogenesis TAS--
    GO:0001568blood vessel development ----
    GO:0001570vasculogenesis IEA--
    GO:0001764neuron migration IEA--

    Find genes that share ontologies with PTK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PTK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Y 11Potent and selective FAK inhibitor[1086639-59-9]
    PF 431396Dual FAK/PYK2 inhibitor[717906-29-1]
    FAK Inhibitor 14Selective FAK inhibitor[4506-66-5]
    PF 573228Potent and selective FAK inhibitor[869288-64-2]

    Selected HMDB Compounds for PTK2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----

    3 DrugBank Compounds for PTK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE-- --target--10592235
    7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE-- --target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target----

    Selected Novoseek inferred chemical compound relationships for PTK2 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.5 1529 16253116 (8), 1385445 (8), 10348703 (8), 8051157 (7) (see all 99)
    phosphotyrosine 78 98 8937737 (4), 7986754 (3), 15554394 (3), 7706413 (2) (see all 54)
    cytochalasin d 73.9 42 11029408 (2), 7556524 (2), 15963258 (1), 16461767 (1) (see all 35)
    phosphatidylinositol 67.2 62 8824286 (6), 10843867 (3), 8694818 (3), 9268316 (1) (see all 42)
    herbimycin a 65.7 12 9566877 (3), 8817517 (2), 11095944 (1), 11581189 (1) (see all 8)
    matrigel 64.2 19 11774285 (2), 11369141 (1), 12595342 (1), 16547501 (1) (see all 11)
    ly294002 63.8 12 18854312 (1), 9990307 (1), 11095944 (1), 19635908 (1) (see all 11)
    echistatin 61.8 13 10931187 (7), 10903427 (3), 15661571 (1), 12147603 (1) (see all 5)
    wortmannin 61.2 22 10537051 (3), 9057639 (2), 10843867 (1), 9990307 (1) (see all 17)
    cilengitide 58.2 6 19212436 (2), 19114005 (1)



    Find genes that share compounds with PTK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PTK2 gene (3 alternative transcripts): 
    NM_001199649.1  NM_005607.4  NM_153831.3  

    Unigene Cluster for PTK2:

    Protein tyrosine kinase 2
    Hs.395482  [show with all ESTs]
    Unigene Representative Sequence: NM_001199649
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 59):
    ENST00000522684(uc011ljp.2 uc003yvp.3 uc003yvq.3 uc003yvr.3 uc003yvs.3 uc003yvu.3)
    ENST00000519654 ENST00000519465(uc003yvo.3) ENST00000517887 ENST00000521059(uc003yvt.3)
    ENST00000517712 ENST00000523539 ENST00000340930 ENST00000519993(uc011ljq.2 uc003yvv.3)
    ENST00000519419 ENST00000524202 ENST00000430260 ENST00000521986 ENST00000523435
    ENST00000522950 ENST00000523805 ENST00000520460 ENST00000521985
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTK2 (see all 23):
    hsa-miR-4251 hsa-let-7a-2* hsa-miR-340 hsa-miR-410 hsa-miR-548a-3p hsa-miR-633 hsa-let-7g* hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidPTK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PTK2
    Predesigned siRNA for gene silencing in human, mouse, rat PTK2
    Clone
    Products:
         
    OriGene clones in human, mouse for PTK2 (see all 16)
    OriGene ORF clones in mouse, rat for PTK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK2 (NM_173174)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK2
    Addgene plasmids for PTK2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PTK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTK2
      QuantiTect SYBR Green Assays in human, mouse, rat PTK2
      QuantiFast Probe-based Assays in human, mouse, rat PTK2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12094) for PTK2 

    Additional mRNA sequence: 

    AB209071.1 AK094999.1 AK124810.1 AK294873.1 AK301557.1 AK304356.1 AL832961.1 BC015361.1 
    BC028733.2 BC035404.2 BC043202.2 L13616.1 

    Selected DOTS entries (see all 54):

    DT.100826838  DT.97762498  DT.86857405  DT.92452096  DT.100826836  DT.100826834  DT.95330431  DT.100767523 
    DT.121493363  DT.92452103  DT.121493349  DT.40252503  DT.92452106  DT.121493412  DT.121493502  DT.100037401 
    DT.121493487  DT.40226695  DT.92452098  DT.99939714  DT.104825  DT.121493454  DT.92031262  DT.92042671 

    Selected AceView cDNA sequences (see all 332):

    BG260768 AA089644 CR616513 BQ771723 AI280857 BC015361 AI632051 CA390101 
    AI262295 F03753 BC035404 CA448542 BX479808 CB961426 AA031670 CB155981 
    AL832961 AI818856 AI341506 BC028733 AA983644 BX355730 AA554361 AI635043 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTK2 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                          -     -     -                 -     -     -     -     -     -           -                       -                                 
    SP2:                                                                                                  -                       -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36a ·
    SP1:                                -                       -           -                             -     -                                               -   
    SP2:                                -                       -           -                             -     -                 -     -                       -   
    SP3:                                -                                   -                             -     -                                         -     -   
    SP4:                                                        -           -                             -     -                                               -   
    SP5:                                                                                                        -                                                   

    ExUns: 36b ^ 37 ^ 38a · 38b · 38c ^ 39 ^ 40 ^ 41 ^ 42a · 42b · 42c
    SP1:              -                       -     -                     
    SP2:              -                       -     -                     
    SP3:              -                       -     -                     
    SP4:              -                       -     -                     
    SP5:                                                                  


    ECgene alternative splicing isoforms for PTK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PTK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTK2 Expression
    About this image


    PTK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Meningeal Fibroblasts Anterior Pia Mater
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytes Autopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytes Autopod Epiphyseal End
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Lens Vesicle Cells Lens Vesicle
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Common Dendritic Cell Precursors Hematopoietic Bone Marrow
    PTK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.395482

    UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
    Tissue specificity: Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at
    protein level). Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTK2 (see all 12): 
              Lymphoma in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PTK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTK2
    QuantiTect SYBR Green Assays in human, mouse, rat PTK2
    QuantiFast Probe-based Assays in human, mouse, rat PTK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for PTK2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptk21 , 5 PTK2 protein tyrosine kinase 21, 5 90.75(n)1
    97.34(a)1
      15 (33.94 cM)5
    140831  NM_007982.21  NP_032008.21 
     732051055 
    chicken
    (Gallus gallus)
    Aves PTK21 PTK2 protein tyrosine kinase 2 83.86(n)
    94.86(a)
      396416  NM_205435.1  NP_990766.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTK26
    protein tyrosine kinase 2
    86(a)
    1 ↔ 1
    4(15476845-15611749)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68192 Xenopus laevis focal adhesion kinase pp125FAK mRNA, complete cds less 79.58(n)    U11078.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ptk22 protein tyrosine kinase 2 77.53(n)   142986  AF348085.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fak56D3
    Fak1
    cytoskeletal anchoring protein tyrosine
    kinase less3
    Focal adhesion kinase1
    37(a)3
    48.81(n)1
    42.58(a)1
      56D53
    372331  NM_001144247.21  NP_001137719.21 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-321 , 3 protein kinase3
    kin-321
    35(a)3
    48.08(n)1
    36.73(a)1
      1721351  NM_170854.31  NP_740841.11 


    ENSEMBL Gene Tree for PTK2 (if available)
    TreeFam Gene Tree for PTK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTK2 gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  ERBB22  ZAP702  EGFR2  PTK2B2  
    Selected SIMAP similar genes for PTK2 using alignment to 36 protein entries:     FAK1_HUMAN (see all proteins) (see all similar genes):
    DKFZp666O0110    EPHA4    FLT4    FES    TYK2    TNK2
    ABL1    MET    EPHA6    A20    ALK    EML4-ALK
    EPHB1    FRK    PPFIBP1-ALK    SQSTM1-ALK    PTK2B    FGFR1

    Find genes that share paralogs with PTK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTK2 (see all 6633)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0416844
    A glioblastoma multiforme sample4--see VAR_0416842 V A mis40--------
    VAR_0416864
    A metastatic melanoma sample4--see VAR_0416862 K E mis40--------
    rs1892410801,2
    --136989996(+) ATATAC/TATATA 3 -- int10--------
    rs737147171,2
    C,F--136990012(+) ATATAC/TACACT 3 -- int11Minor allele frequency- T:0.00WA 2
    rs605278981,2
    C--137004434(+) AAAAA-/A/AA  
            
    GCTTC
    3 -- int11NA 2
    rs1511551421,2
    C--137018482(+) GGTTT-/ACTG  
            
    TTTTT
    3 -- int10--------
    rs1380949791,2
    C--137024438(+) AGAAT-/AACAACAA 3 -- int10--------
    rs778847331,2
    C--137024440(+) AATAAC/TAACAA 3 -- int10--------
    rs670162251,2
    C--137028389(+) GGCAG-/CCGGCA 3 -- int10--------
    rs113068111,2
    C--137036624(+) CTTTT-/AAAAAA 3 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for PTK2 (141667999 - 141917999 bp, first 250kb of PTK2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTK2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665041CNV Deletion23128226
    esv2737756CNV Deletion23290073
    esv2670372CNV Deletion23128226
    esv2422061CNV Duplication20811451
    esv1765152CNV Insertion17803354
    esv1325604CNV Insertion17803354
    nsv831482CNV Loss17160897
    nsv438084CNV Loss16468122
    nsv465952CNV Loss19166990
    esv23036CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    3 Copy Number PCR Panels containing PTK2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing PTK2
    DNA2.0 Custom Variant and Variant Library Synthesis for PTK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600758    OMIM disorders: --

    UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
  • Note=Aberrant PTK2/FAK1 expression may play a role in cancer cell proliferation, migration and invasion,
    in tumor formation and metastasis. PTK2/FAK1 overexpression is seen in many types of cancer

  • 4 diseases for PTK2:    
    About MalaCards
    scar contracture    askin's tumor    gastroesophageal junction adenocarcinoma    breast cancer


    Find genes that share disorders with PTK2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTK2 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 62.9 131 17309983 (4), 17687194 (3), 18606490 (3), 16638855 (3) (see all 81)
    tumors 58.5 433 18987997 (8), 19521985 (7), 17185517 (5), 11359909 (5) (see all 99)
    cancer 56.3 217 19169797 (5), 20014455 (4), 12884911 (4), 17907961 (3) (see all 99)
    colon cancer 50.5 63 12939401 (4), 10873094 (3), 16998832 (3), 16001424 (2) (see all 34)
    breast cancer 47.6 132 12167618 (4), 19671193 (4), 18383836 (4), 20101634 (4) (see all 44)
    breast carcinoma 39.2 24 17884781 (8), 16547501 (1), 17549404 (1), 9164861 (1) (see all 14)
    glioblastoma 37.8 30 16288224 (4), 12784878 (3), 19268501 (2), 11479198 (2) (see all 14)
    hepatocellular carcinoma 37.7 31 12549072 (3), 11783016 (3), 16094707 (2), 18979199 (2) (see all 17)
    melanoma 37.6 64 16179862 (4), 16552181 (4), 18606490 (4), 11683393 (3) (see all 30)
    glioma 33.6 41 17219439 (4), 16424009 (2), 17332925 (2), 17431114 (2) (see all 22)

    Genetic Association Database (GAD): PTK2
    Human Genome Epidemiology (HuGE) Navigator: PTK2 (6 documents)
    Tumor Gene Database (TGDB): PTK2

    Export disorders for PTK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTK2 gene, integrated from 10 sources (see all 1644):
    (articles sorted by number of sources associating them with PTK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of an N-terminally truncated form of human focal adhesion kinase in brain. (PubMed id 8422239)1, 2, 3 Andre E. and Becker-Andre M. (Biochem. Biophys. Res. Commun. 1993)
    2. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. (PubMed id 15855171)1, 2, 9 Golubovskaya V.M.... Cance W.G. (J. Biol. Chem. 2005)
    3. Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. (PubMed id 7692878)1, 2, 9 Whitney G.S.... Kanner S.B. (DNA Cell Biol. 1993)
    4. Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts. (PubMed id 20109444)1, 2, 9 Cai G.Q.... Ding Q. (Exp. Cell Res. 2010)
    5. Integrin-regulated FAK-Src signaling in normal and cancer cells. (PubMed id 16919435)1, 2, 9 Mitra S.K. and Schlaepfer D.D. (Curr. Opin. Cell Biol. 2006)
    6. A novel Cas family member, HEPL, regulates FAK and cell spreading. (PubMed id 18256281)1, 2, 9 Singh M.K.... Golemis E.A. (Mol. Biol. Cell 2008)
    7. Focal adhesion kinase and p53 signal transduction pathways in cancer. (PubMed id 20515733)1, 2, 9 Golubovskaya V.M. and Cance W. (Front. Biosci. 2010)
    8. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. (PubMed id 19147981)1, 2, 9 Pylayeva Y....Giancotti F.G. (J. Clin. Invest. 2009)
    9. Nuclear FAK promotes cell proliferation and survival through FERM- enhanced p53 degradation. (PubMed id 18206965)1, 2, 9 Lim S.T.... Ilic D. (Mol. Cell 2008)
    10. Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5. (PubMed id 16927379)1, 2, 9 Salasznyk R.M.... Plopper G.E. (J. Cell. Biochem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5747 HGNC: 9611 AceView: PTK2 Ensembl:ENSG00000169398 euGenes: HUgn5747
    ECgene: PTK2 Kegg: 5747 H-InvDB: PTK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTK2 gene:
    Search GeneIP for patents involving PTK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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