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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTK2 Gene

protein-coding   GIFtS: 73
GCID: GC08M141667

protein tyrosine kinase 2

(Previous name: PTK2 protein tyrosine kinase 2 )
 Explore 118 diseases affiliated with
PTK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTK2    

Aliases
for PTK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Tyrosine Kinase 21 2     FADK 12 3
FAK1 2 3     P125FAK1
FAK11 2 3     Pp125FAK1
PPP1R711 2 3     EC 2.7.10.23 8
FADK1 2 5     FAK-Related Non-Kinase Polypeptide2
PTK2 Protein Tyrosine Kinase 21 2     Focal Adhesion Kinase 12
Focal Adhesion Kinase-Related Nonkinase2 3     Protein Phosphatase 1, Regulatory Subunit 712
Protein Phosphatase 1 Regulatory Subunit 712 3     Protein-Tyrosine Kinase 23
FRNK2 3     EC 2.7.108

External Ids:    HGNC: 96111   Entrez Gene: 57472   Ensembl: ENSG000001693987   OMIM: 6007585   UniProtKB: Q053973   

Export aliases for PTK2 gene to outside databases

Previous GC identifers: GC08M140557 GC08M141856 GC08M141352 GC08M141639 GC08M141737 GC08M136979


Summaries
for PTK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTK2:
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form
between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK
subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways
triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several
transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only
three of them have been determined. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
Function: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion,
spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell
protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and
placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and
normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation;
required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of
osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor
receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling
complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine
residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling
pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of
MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine
nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho
family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to
P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation.
Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes
phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is
recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2
and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not
contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate
the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene
transcription

summary for PTK2:
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal
transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known
as focal adhesions. Therefore, FAK is plays a key role in cellular migration and motility. FAK has 3
functional domains: a focal adhesion targeting domain (FAT), a catalytic domain and a FERM domain, which
mediates interactions with the cytoplasmic domains of integrins and growth factor receptors. FAK has
multiple phosphorylation sites that are required for binding to adaptor proteins containing SH2 domains
(e.g. Src and SH3 domains (e.g. CAS, GRAF)). Key amongst these phosphorylation sites is Tyr397, which is
important for the interaction of FAK with downstream signaling molecules such as PI 3-K, PLCgamma and Rho
kinase. Overexpression of FAK has been associated with several types of cancer.

Gene Wiki entry for PTK2


Genomic Views
for PTK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTK2 gene promoter:
         SRF   CREB   AP-1   SRF (504 AA)   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

PTK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTK2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M141667:  view genomic region     (about GC identifiers)

Start:
 141,667,999 bp from pter      End:
 142,012,315 bp from pter
Size:
 344,317 bases      Orientation:
 minus strand

Proteins
for PTK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397 (See protein sequence)
Recommended Name: Focal adhesion kinase 1  
Size: 1052 amino acids; 119233 Da
Subunit: Interacts (via first Pro-rich region) with CAS family members (via SH3 domain), including BCAR1, BCAR3, CASS4
and NEDD9. Interacts with GIT1. Interacts with SORBS1. Interacts with ARHGEF28. Interacts with SHB. Interacts with PXN
and TLN1. Interacts with STAT1. Interacts with DCC. Interacts with WASL. Interacts with ARHGEF7. Interacts with GRB2
and GRB7 (By similarity). Component of a complex that contains at least FER, CTTN and PTK2/FAK1. Interacts with BMX.
Interacts with TGFB1I1. Interacts with STEAP4. Interacts with ZFYVE21. Interacts with ESR1. Interacts with PIK3R1 or
PIK3R2. Interacts with SRC, FGR, FLT4 and RET. Interacts with EPHA2 in resting cells; activation of EPHA2 recruits
PTPN11, leading to dephosphorylation of PTK2/FAK1 and dissociation of the complex. Interacts with EPHA1 (kinase
activity-dependent). Interacts with CD4; this interaction requires the presence of HIV-1 gp120. Interacts with PIAS1.
Interacts with ARHGAP26 and SHC1. Interacts with RB1CC1; this inhibits PTK2/FAK1 activity and activation of downstream
signaling pathways. Interacts with P53/TP53 and MDM2. Interacts with LPXN (via LD motif 3)
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome (By similarity). Nucleus.
Note=Constituent of focal adhesions. Detected at microtubules
Developmental stage: Isoform 6 is detected in cultured cells, immediately after seeding and before formation of focal
adhesions (at protein level)
6/16 PDB 3D structures from and Proteopedia for PTK2 (see all 16):
1K04 (3D)        1K05 (3D)        1MP8 (3D)        1OW6 (3D)        1OW7 (3D)        1OW8 (3D)    
Secondary accessions: B4E2N6 F5H4S4 Q14291 Q9UD85
Alternative promoter usage, Alternative splicing: 6 isoforms:  Q05397-1   Q05397-2   Q05397-3   Q05397-4   Q05397-5   Q05397-6   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for PTK2: NX_Q05397

Post-translational modifications:

  • Phosphorylated on tyrosine residues upon activation, e.g. upon integrin signaling. Tyr-397 is the major
    • autophosphorylation site, but other kinases can also phosphorylate this residue. Phosphorylation at Tyr-397 promotes
    interaction with SRC and SRC family members, leading to phosphorylation at Tyr-576, Tyr-577 and at additional tyrosine
    residues. FGR promotes phosphorylation at Tyr-397 and Tyr-576. FER promotes phosphorylation at Tyr-577, Tyr-861 and
    Tyr-925, even when cells are not adherent. Tyr-397, Tyr-576 and Ser-722 are phosphorylated only when cells are
    adherent. Phosphorylation at Tyr-397 is important for interaction with BMX, PIK3R1 and SHC1. Phosphorylation at
    Tyr-925 is important for interaction with GRB2. Dephosphorylated by PTPN11; PTPN11 is recruited to PTK2 via EPHA2
    (tyrosine phosphorylated). Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal
    adhesion disassembly; this dephosphorylation could be catalyzed by PTPN11 and regulated by ZFYVE211
  • Sumoylated; this enhances autophosphorylation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05397

    • 4/24 DME Specific Peptides for PTK2 (Q05397) (see all 24)
     VCMWEIL  PTANLDR  AARNVLV  SEEVHWLH 

    PTK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186578.1  NP_005598.3  NP_722560.1  

    ENSEMBL proteins: 
     ENSP00000429911   ENSP00000429929   ENSP00000429170   ENSP00000429082   ENSP00000429474  
     ENSP00000430916   ENSP00000428492   ENSP00000341189   ENSP00000428570   ENSP00000429129  
     ENSP00000429023   ENSP00000403416   ENSP00000430603   ENSP00000430828   ENSP00000429437  
     ENSP00000427774   ENSP00000431106   ENSP00000427972   ENSP00000429702   ENSP00000428593  
     ENSP00000429958   ENSP00000428482   ENSP00000428380   ENSP00000428232   ENSP00000429001  
     ENSP00000427825   ENSP00000429895   ENSP00000427762   ENSP00000428792   ENSP00000430277  
     ENSP00000427904   ENSP00000429530   ENSP00000427795   ENSP00000430951   ENSP00000430044  
     ENSP00000429907   ENSP00000429409   ENSP00000430037   ENSP00000429028   ENSP00000431023  
     ENSP00000438009   ENSP00000378644   ENSP00000445742  
    Reactome Protein details: Q05397
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PTK2 Protein
    R&D Systems Recombinant & Natural Proteins for PTK2 (FAK)
    Enzo Life Sciences proteins for PTK2
    OriGene Purified Proteins (see all 2): PTK2
    OriGene Protein Over-expression Lysate (see all 3): PTK2
    OriGene Custom Protein Services for PTK2 
    GenScript Purified and Recombinant Proteins for PTK2
    Novus Biologicals PTK2 Proteins
    Novus Biologicals PTK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PTK2

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15855171
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--


    PTK2 for ontologies           About GeneDecksing



    PTK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTK2
    R&D Systems Antibodies for PTK2 (FAK)
    Cell Signaling Technology (CST) Antibodies for PTK2  (FAK)
    OriGene Antibodies (see all 9): PTK2
    OriGene Custom Antibody Services for PTK2 
    GenScript Custom Superior Antibodies Services for PTK2
    Novus Biologicals PTK2 Antibodies
    Abcam antibodies for PTK2 
    Uscn Antibodies for PTK2
    ThermoFisher Antibody for PTK2

    Assay Products for PTK2: 
    EMD Millipore Kits and Assays for the Analysis of PTK2
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for PTK2 (FAK)         (see all)
    GenScript Custom Assay Services for PTK2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PTK2

    Protein Domains /
    Families
    for PTK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTK2 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR019748 FERM_central
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR005189 Focal_adhesion_kin_target_dom

    Graphical View of Domain Structure for InterPro Entry Q05397

    ProtoNet protein and cluster: Q05397

    2 Blocks protein families:
    IPB005189 Focal adhesion targeting region
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
    Domain: The Pro-rich regions interact with the SH3 domain of CAS family members, such as BCAR1 and NEDD9, and with the
    GTPase activating protein ARHGAP26
    Domain: The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the
    localization of FAK1 to focal adhesions
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 protein kinase domain


    Function
    for PTK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
    Function: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion,
    spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell
    protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and
    placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and
    normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation;
    required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of
    osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor
    receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling
    complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine
    residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling
    pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of
    MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine
    nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho
    family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to
    P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation.
    Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes
    phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is
    recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2
    and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not
    contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate
    the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene
    transcription
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Subject to autoinhibition, mediated by interactions between the FERM domain and the kinase domain.
    Activated by autophosphorylation at Tyr-397. This promotes interaction with SRC and phosphorylation at Tyr-576 and
    Tyr-577 in the kinase activation loop. Phosphorylation at Tyr-576 and Tyr-577 is required for maximal kinase activity.
    Inhibited by TAC544, TAE226, PF-573,228 and PF-562,271

         Genatlas biochemistry entry for PTK2:
    focal adhesion kinase 1,pp125FAK,widely expressed in T and B lymphocytes,with a splice variant,FAK1A,expressed in
    brain,primary mediator of integrin signaling after integrin mediated cell adhesion and FAK phosphorylation,also
    mediating a direct interaction with the C terminal SH2 domain of phospholipase C (PCLG1)

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target PTK2:
    hsa-mir-193a-3p (MIRT004001)

    OriGene 3'-UTR Clone (see all 2): PTK2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTK2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTK2 (see all 23):
    hsa-miR-4251 hsa-let-7a-2* hsa-miR-340 hsa-miR-410 hsa-miR-548a-3p hsa-miR-633 hsa-let-7g* hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: PTK2 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of PTK2 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTK2 (see all 7)
    OriGene shRNA RFP: PTK2
    OriGene siRNA: PTK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTK2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PTK2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK2 (NM_173174)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PTK2
    Search LifeMap BioReagents cell lines for PTK2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK2

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA16803572
    GO:0004672protein kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA11331870
    GO:0004871signal transducer activity IEA--


    PTK2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PTK2:
     Decreased substrate adherent c  Decreased viability in HMC1.1   Decreased viability with pacli  Increased circadian period len 
     Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for PTK2: Ptk2tm1Ilic Ptk2tm1Imeg Ptk2tm1.1Jtpa Ptk2tm1.2Guan
         15/20 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Ptk2) (see all 20):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    PTK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/79 super-pathways (see all 79) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Integrin outside-in signaling0.37
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    		Cytoskeleton remodeling_Integrin outside-in signaling0.37
    		Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility0.32
    2Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4Cytoskeleton remodeling Slit-Robo signaling
    		Cytoskeleton remodeling Slit-Robo signaling1.00
    		Cell adhesion_Cadherin-mediated cell adhesion0.28
    		Development_Slit-Robo signaling0.92
    		Cell adhesion Cadherin-mediated cell adhesion0.28
    5Focal Adhesion
    		Focal Adhesion1.00
    		Integrin-mediated cell adhesion0.38
    		Focal adhesion0.66
    		HGF Pathway0.24

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/15 EMD Millipore Pathways for PTK2 (see all 15)
        Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling Integrin outside-in signaling
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cell adhesion PLAU signaling

    5/40 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTK2 (see all 40)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for PTK2
        Tyrosine Kinases / Adaptors
    Adhesion

    3 Tocris Bioscience Pathways for PTK2
        Akt Pathway
    VEGF Pathway
    MAPK Pathway

    5/16 GeneGo (Thomson Reuters) Pathways for PTK2 (see all 16)
        Development VEGF signaling via VEGFR2 - generic cascades
    Cell adhesion Integrin inside-out signaling
    Development EGFR signaling pathway
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility

    5/17 BioSystems Pathways for PTK2 (see all 17) 
        Integrin-mediated cell adhesion
    ErbB signaling pathway
    Angiogenesis
    Focal Adhesion
    Regulation of Actin Cytoskeleton

    5/23        Reactome Pathways for PTK2 (see all 23)
        Developmental Biology
    Apoptosis
    GRB2:SOS provides linkage to MAPK signaling for Intergrins
    Signal regulatory protein (SIRP) family interactions
    Signal Transduction


    5/11         Kegg Pathways  (Kegg details for PTK2) (see all 11):
        ErbB signaling pathway
    Chemokine signaling pathway
    Axon guidance
    VEGF signaling pathway
    Focal adhesion


    PTK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/270 Interacting proteins for PTK2 (Q053971, 2, 3 ENSP000003411894) via UniProtKB, MINT, STRING, and/or I2D (see all 270)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-702142,EBI-366083 MINT-7294020 I2D: score=4 STRING: ENSP00000269305
    GRB2P629932, 3, ENSP000003390074MINT-8036897 MINT-8256602 I2D: score=7 STRING: ENSP00000339007
    BCAR1P569452, 3, ENSP000001623304MINT-74938 I2D: score=9 STRING: ENSP00000162330
    DDX39AO001482, 3, ENSP000002427764MINT-8267513 I2D: score=2 STRING: ENSP00000242776
    EPS8L2Q9H6S32, 3, ENSP000003208284MINT-8267541 I2D: score=2 STRING: ENSP00000320828
    About this table

    Gene Ontology (GO): 5/66 biological process terms (GO ID links to tree view) (see all 66):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0001525angiogenesis TAS--
    GO:0001568blood vessel development ----
    GO:0001570vasculogenesis IEA--
    GO:0001764neuron migration IEA--


    PTK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for PTK2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PTK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Y 11Potent and selective FAK inhibitor[1086639-59-9]
    FAK Inhibitor 14Selective FAK inhibitor[4506-66-5]
    PF 573228Potent and selective FAK inhibitor[869288-64-2]

    10/12 HMDB Compounds for PTK2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----

    3 DrugBank Compounds for PTK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE-- --target--10592235
    7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE-- --target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target----

    10/125 Novoseek chemical compound relationships for PTK2 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.5 1529 16253116 (8), 1385445 (8), 10348703 (8), 8051157 (7) (see all 99)
    phosphotyrosine 78 98 8937737 (4), 7986754 (3), 15554394 (3), 7706413 (2) (see all 54)
    cytochalasin d 73.9 42 11029408 (2), 7556524 (2), 15963258 (1), 16461767 (1) (see all 35)
    phosphatidylinositol 67.2 62 8824286 (6), 10843867 (3), 8694818 (3), 9268316 (1) (see all 42)
    herbimycin a 65.7 12 9566877 (3), 8817517 (2), 11095944 (1), 11581189 (1) (see all 8)
    matrigel 64.2 19 11774285 (2), 11369141 (1), 12595342 (1), 16547501 (1) (see all 11)
    ly294002 63.8 12 18854312 (1), 9990307 (1), 11095944 (1), 19635908 (1) (see all 11)
    echistatin 61.8 13 10931187 (7), 10903427 (3), 15661571 (1), 12147603 (1) (see all 5)
    wortmannin 61.2 22 10537051 (3), 9057639 (2), 10843867 (1), 9990307 (1) (see all 17)
    cilengitide 58.2 6 19212436 (2), 19114005 (1)

    Search CenterWatch for drugs/clinical trials and news about PTK2 / FAK1 

    Transcripts
    for PTK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTK2 gene (3 alternative transcripts): 
    NM_001199649.1  NM_005607.4  NM_153831.3  

    Unigene Cluster for PTK2:

    PTK2 protein tyrosine kinase 2
    Hs.395482  [show with all ESTs]
    Unigene Representative Sequence: NM_001199649
    18/59 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 59):
    ENST00000522684(uc011ljp.2 uc003yvp.3 uc003yvq.3 uc003yvr.3 uc003yvs.3 uc003yvu.3)
    ENST00000519654 ENST00000519465(uc003yvo.3) ENST00000517887 ENST00000521059(uc003yvt.3)
    ENST00000517712 ENST00000523539 ENST00000340930 ENST00000519993(uc011ljq.2 uc003yvv.3)
    ENST00000519419 ENST00000524202 ENST00000430260 ENST00000521986 ENST00000523435
    ENST00000522950 ENST00000523805 ENST00000520460 ENST00000521985

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): PTK2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTK2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTK2 (see all 23):
    hsa-miR-4251 hsa-let-7a-2* hsa-miR-340 hsa-miR-410 hsa-miR-548a-3p hsa-miR-633 hsa-let-7g* hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: PTK2 3' UTR sequence
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of PTK2 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTK2 (see all 7)
    OriGene shRNA RFP: PTK2
    OriGene siRNA: PTK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTK2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTK2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PTK2 (NM_173174)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTK2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTK2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTK2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTK2

    Additional cDNA sequence: 

    AB209071.1 AK094999.1 AK124810.1 AK294873.1 AK301557.1 AK304356.1 AL832961.1 BC015361.1 
    BC028733.2 BC035404.2 BC043202.2 L13616.1 

    24/54 DOTS entries (see all 54):

    DT.100826838  DT.97762498  DT.86857405  DT.92452096  DT.100826836  DT.100826834  DT.95330431  DT.100767523 
    DT.121493363  DT.92452103  DT.121493349  DT.40252503  DT.92452106  DT.121493412  DT.121493502  DT.100037401 
    DT.121493487  DT.40226695  DT.92452098  DT.99939714  DT.104825  DT.121493454  DT.92031262  DT.92042671 

    24/332 AceView cDNA sequences (see all 332):

    N42230 BQ438629 AI911936 CB990597 AI280857 BU193994 AU139054 AU124489 
    AW576492 CB961426 AW236685 AI126054 AA089644 BG260768 NM_153831 CF138217 
    BU676501 F02630 CA391975 AA983514 BX355730 AI566853 BC035404 AA907418 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for PTK2 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                          -     -     -                 -     -     -     -     -     -           -                       -                                 
    SP2:                                                                                                  -                       -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36a ·
    SP1:                                -                       -           -                             -     -                                               -   
    SP2:                                -                       -           -                             -     -                 -     -                       -   
    SP3:                                -                                   -                             -     -                                         -     -   
    SP4:                                                        -           -                             -     -                                               -   
    SP5:                                                                                                        -                                                   

    ExUns: 36b ^ 37 ^ 38a · 38b · 38c ^ 39 ^ 40 ^ 41 ^ 42a · 42b · 42c
    SP1:              -                       -     -                     
    SP2:              -                       -     -                     
    SP3:              -                       -     -                     
    SP4:              -                       -     -                     
    SP5:                                                                  


    ECgene alternative splicing isoforms for PTK2

    Expression
    for PTK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/27 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 27) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneStylopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneZeugopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BrainAnterior Pia MaterMeningeal FibroblastsMeninges
    LimbAutopodMesenchymal Condensate CellsBone, Cartilage
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    LimbStylopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTK2

    SOURCE GeneReport for Unigene cluster: Hs.395482

    UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
    Tissue specificity: Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at
    protein level). Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including PTK2 (see all 12): 
              Lymphoma in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTK2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTK2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTK2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTK2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTK2

    Orthologs
    for PTK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTK2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PTK21 PTK2 protein tyrosine kinase 2 83.86(n)
    94.86(a)    		   396416  NM_205435.1  NP_990766.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PTK26
    		 --
    		 91(a)
    		 1 ↔ 1
    		 4(15495901-15611749)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.68192 Xenopus laevis focal adhesion kinase pp125FAK mRNA, complete cds less 79.58(n)    U11078.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ptk22 protein tyrosine kinase 2 77.53(n)   142986  AF348085.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Fak56D1 , 3 cytoskeletal anchoring protein tyrosine
    kinase less3
    Focal Adhesion Kinase1    		 37(a)3
    48.89(n)1
    42.92(a)1    		   56D53
    372331  NM_001144247.21  NP_001137719.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea kin-321 , 3 protein kinase3
    Protein KIN-321    		 35(a)3
    47.83(n)1
    36.45(a)1    		   1721351  NM_170854.21  NP_740841.11 


    ENSEMBL Gene Tree for PTK2 (if available)
    TreeFam Gene Tree for PTK2 (if available) 

    Paralogs
    for PTK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTK2 gene
    SYK2  TNK12  JAK22  JAK32  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  ERBB22  ZAP702  PTK2B2  EGFR2  
    18/54 SIMAP similar genes for PTK2 using alignment to 36 protein entries:     FAK1_HUMAN (see all proteins) (see all similar genes):
    DKFZp666O0110    EPHA4    FLT4    FES    TYK2    TNK2
    ABL1    MET    EPHA6    ALK    EML4-ALK    EPHB1
    FRK    PPFIBP1-ALK    SQSTM1-ALK    PTK2B    FGFR1    DKFZp434L0319

    PTK2 for paralogs           About GeneDecksing



    Genomic Variants
    for PTK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5400 NCBI SNPs in PTK2 are shown (see all 5400)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs758840901,2
    		F,--136978818(+) AAGGTT/GCTTTC 3 -- ds50011Minor allele frequency- G:0.09WA 118
    rs101086151,2
    		C,F,H,--136978820(+) GGTTCT/CTTCAT 3 -- ds500111Minor allele frequency- C:0.03NS EA NA WA 1310
    rs43205281,2
    		H--136979043(+) GCCATC/TTGAAG 3 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs2010703071,2
    		C--136979310(+) GGCTGG/TAAAAT 3 -- ut310--------
    rs752779901,2
    		F,--136979851(+) GAACAT/CAAATT 3 -- ut311Minor allele frequency- C:0.02WA 118
    rs413055271,2
    		--136979907(+) AAAAAC/TGCCAC 3 -- ut310--------
    rs559394211,2
    		C,F--136980161(+) GGTCTC/TGTCTG 6 T syn11Minor allele frequency- T:0.00NA 4544
    rs1998731621,2
    		C--136980412(+) TTTTTC/TCTTTT 3 -- int10--------
    rs785689101,2
    		F,--136980636(+) CAATAG/TGATGT 3 -- int11Minor allele frequency- T:0.04WA 118
    rs100882341,2
    		C,F,H,--136980655(+) ATCTTT/AAAATT 3 -- int15Minor allele frequency- A:0.03NS EA WA 492

    HapMap Linkage Disequilibrium report for PTK2 (141667999 - 141917999 bp, first 250kb of PTK2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for PTK2
         4 CNVs: 1806 31454 65286 82807

    SABiosciences Cancer Mutation PCR Assays
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing PTK2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTK2
    DNA2.0 Custom Variant and Variant Library Synthesis for PTK2

    Disorders / Diseases
    for PTK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTK2 for disorders           About GeneDecksing

    OMIM gene information: 600758    OMIM disorders: --

    UniProtKB/Swiss-Prot: FAK1_HUMAN, Q05397
  • Note=Aberrant PTK2/FAK1 expression may play a role in cancer cell proliferation, migration and invasion, in
    • tumor formation and metastasis. PTK2/FAK1 overexpression is seen in many types of cancer

    20/118 diseases for PTK2 (see all 118):    About MalaCards
    estrogen-receptor positive breast cancer    glanzmann's thrombasthenia    gastroesophageal junction adenocarcinoma    wiskott-aldrich syndrome
    laryngeal squamous cell carcinoma    squamous cell carcinoma    clostridium difficile    muscular dystrophy
    thrombasthenia    bile duct carcinoma    gastrointestinal stromal tumor    askin's tumor
    congenital muscular dystrophy    carcinoma    myeloid leukemia    myocardial infarction
    oral squamous cell carcinoma    malignant glioma    acute myocardial infarction    esophageal squamous cell carcinoma

    10/95 Novoseek disease relationships for PTK2 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 62.9 131 17309983 (4), 17687194 (3), 18606490 (3), 16638855 (3) (see all 81)
    tumors 58.5 433 18987997 (8), 19521985 (7), 17185517 (5), 11359909 (5) (see all 99)
    cancer 56.3 217 19169797 (5), 20014455 (4), 12884911 (4), 17907961 (3) (see all 99)
    colon cancer 50.5 63 12939401 (4), 10873094 (3), 16998832 (3), 16001424 (2) (see all 34)
    breast cancer 47.6 132 12167618 (4), 19671193 (4), 18383836 (4), 20101634 (4) (see all 44)
    breast carcinoma 39.2 24 17884781 (8), 16547501 (1), 17549404 (1), 9164861 (1) (see all 14)
    glioblastoma 37.8 30 16288224 (4), 12784878 (3), 19268501 (2), 11479198 (2) (see all 14)
    hepatocellular carcinoma 37.7 31 12549072 (3), 11783016 (3), 16094707 (2), 18979199 (2) (see all 17)
    melanoma 37.6 64 16179862 (4), 16552181 (4), 18606490 (4), 11683393 (3) (see all 30)
    glioma 33.6 41 17219439 (4), 16424009 (2), 17332925 (2), 17431114 (2) (see all 22)

    Genetic Association Database (GAD): PTK2
    Human Genome Epidemiology (HuGE) Navigator: PTK2 (6 documents)
    Tumor Gene Database (TGDB): PTK2

    Export disorders for PTK2 gene to outside databases

    Publications
    for PTK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTK2 gene, integrated from 9 sources (see all 1590):
    (articles sorted by number of sources associating them with PTK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of an N-terminally truncated form of human focal adhesion kinase in brain. (PubMed id 8422239)1, 2, 3 Andre E. and Becker-Andre M. (1993)
    2. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. (PubMed id 15855171)1, 2, 9 Golubovskaya V.M....Cance W.G. (2005)
    3. Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. (PubMed id 7692878)1, 2, 9 Whitney G.S.... Kanner S.B. (1993)
    4. Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts. (PubMed id 20109444)1, 2, 9 Cai G.Q....Ding Q. (2010)
    5. Integrin-regulated FAK-Src signaling in normal and cancer cells. (PubMed id 16919435)1, 2, 9 Mitra S.K. and Schlaepfer D.D. (2006)
    6. A novel Cas family member, HEPL, regulates FAK and cell spreading. (PubMed id 18256281)1, 2, 9 Singh M.K.... Golemis E.A. (2008)
    7. Focal adhesion kinase and p53 signal transduction pat hways in cancer. (PubMed id 20515733)1, 2, 9 Golubovskaya V.M. and Cance W. (2010)
    8. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. (PubMed id 19147981)1, 2, 9 Pylayeva Y....Giancotti F.G. (2009)
    9. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. (PubMed id 18206965)1, 2, 9 Lim S.T....Ilic D. (2008)
    10. Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5. (PubMed id 16927379)1, 2, 9 Salasznyk R.M....Plopper G.E. (2007)

    External Searches for PTK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing PTK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5747 HGNC: 9611 AceView: PTK2 Ensembl:ENSG00000169398 euGenes: HUgn5747
    ECgene: PTK2 Kegg: 5747 H-InvDB: PTK2

    Other Databases showing PTK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTK2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PTK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTK2 gene:
    Search GeneIP for patents involving PTK2

    GeneCards and IP:
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