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Aliases for PTK2 Gene

Aliases for PTK2 Gene

  • Protein Tyrosine Kinase 2 2 3
  • Protein Phosphatase 1 Regulatory Subunit 71 3 4
  • Focal Adhesion Kinase-Related Nonkinase 3 4
  • PTK2 Protein Tyrosine Kinase 2 2 3
  • EC 2.7.10.2 4 64
  • Pp125FAK 3 4
  • PPP1R71 3 4
  • P125FAK 3 4
  • FADK 1 3 4
  • FADK 3 6
  • FAK1 3 4
  • FRNK 3 4
  • FAK 3 4
  • Protein Phosphatase 1, Regulatory Subunit 71 3
  • Focal Adhesion Kinase Isoform FAK-Del33 3
  • FAK-Related Non-Kinase Polypeptide 3
  • Protein-Tyrosine Kinase 2 4
  • Focal Adhesion Kinase 1 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 71 2
  • EC 2.7.10 64

External Ids for PTK2 Gene

Summaries for PTK2 Gene

Entrez Gene Summary for PTK2 Gene

  • This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]

GeneCards Summary for PTK2 Gene

PTK2 (Protein Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with PTK2 include scar contracture and breast cancer. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include actin binding and signal transducer activity. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for PTK2 Gene

  • Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

Tocris Summary for PTK2 Gene

  • Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. Therefore, FAK is plays a key role in cellular migration and motility. FAK has 3 functional domains: a focal adhesion targeting domain (FAT), a catalytic domain and a FERM domain, which mediates interactions with the cytoplasmic domains of integrins and growth factor receptors. FAK has multiple phosphorylation sites that are required for binding to adaptor proteins containing SH2 domains (e.g. Src and SH3 domains (e.g. CAS, GRAF)). Key amongst these phosphorylation sites is Tyr397, which is important for the interaction of FAK with downstream signaling molecules such as PI 3-K, PLCgamma and Rho kinase. Overexpression of FAK has been associated with several types of cancer.

Gene Wiki entry for PTK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTK2 Gene

Genomics for PTK2 Gene

Genomic Location for PTK2 Gene

Start:
140,657,900 bp from pter
End:
141,002,216 bp from pter
Size:
344,317 bases
Orientation:
Minus strand

Genomic View for PTK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTK2 Gene

Regulatory Elements for PTK2 Gene

Proteins for PTK2 Gene

  • Protein details for PTK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05397-FAK1_HUMAN
    Recommended name:
    Focal adhesion kinase 1
    Protein Accession:
    Q05397
    Secondary Accessions:
    • B4E2N6
    • F5H4S4
    • J3QT16
    • Q14291
    • Q8IYN9
    • Q9UD85

    Protein attributes for PTK2 Gene

    Size:
    1052 amino acids
    Molecular mass:
    119233 Da
    Quaternary structure:
    • Interacts (via first Pro-rich region) with CAS family members (via SH3 domain), including BCAR1, BCAR3, CASS4 and NEDD9. Interacts with GIT1. Interacts with SORBS1. Interacts with ARHGEF28. Interacts with SHB. Interacts with PXN and TLN1. Interacts with STAT1. Interacts with DCC. Interacts with WASL. Interacts with ARHGEF7. Interacts with GRB2 and GRB7 (By similarity). Component of a complex that contains at least FER, CTTN and PTK2/FAK1. Interacts with BMX. Interacts with TGFB1I1. Interacts with STEAP4. Interacts with ZFYVE21. Interacts with ESR1. Interacts with PIK3R1 or PIK3R2. Interacts with SRC, FGR, FLT4 and RET. Interacts with EPHA2 in resting cells; activation of EPHA2 recruits PTPN11, leading to dephosphorylation of PTK2/FAK1 and dissociation of the complex. Interacts with EPHA1 (kinase activity-dependent). Interacts with CD4; this interaction requires the presence of HIV-1 gp120. Interacts with PIAS1. Interacts with ARHGAP26 and SHC1. Interacts with RB1CC1; this inhibits PTK2/FAK1 activity and activation of downstream signaling pathways. Interacts with P53/TP53 and MDM2. Interacts with LPXN (via LD motif 3). Interacts with MISP. Interacts with CIB1 isoform 2. Interacts with CD36. Interacts with EMP2; regulates PTK2 activation and localization (PubMed:19494199).

    Three dimensional structures from OCA and Proteopedia for PTK2 Gene

    Alternative splice isoforms for PTK2 Gene

neXtProt entry for PTK2 Gene

Proteomics data for PTK2 Gene at MOPED

Post-translational modifications for PTK2 Gene

  • Phosphorylated on tyrosine residues upon activation, e.g. upon integrin signaling. Tyr-397 is the major autophosphorylation site, but other kinases can also phosphorylate this residue. Phosphorylation at Tyr-397 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-576, Tyr-577 and at additional tyrosine residues. FGR promotes phosphorylation at Tyr-397 and Tyr-576. FER promotes phosphorylation at Tyr-577, Tyr-861 and Tyr-925, even when cells are not adherent. Tyr-397, Tyr-576 and Ser-722 are phosphorylated only when cells are adherent. Phosphorylation at Tyr-397 is important for interaction with BMX, PIK3R1 and SHC1. Phosphorylation at Tyr-925 is important for interaction with GRB2. Dephosphorylated by PTPN11; PTPN11 is recruited to PTK2 via EPHA2 (tyrosine phosphorylated). Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly; this dephosphorylation could be catalyzed by PTPN11 and regulated by ZFYVE21.
  • Sumoylated; this enhances autophosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PTK2 Gene

Gene Families for PTK2 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
IUPHAR :

UniProtKB/Swiss-Prot:

FAK1_HUMAN
Domain:
  • The Pro-rich regions interact with the SH3 domain of CAS family members, such as BCAR1 and NEDD9, and with the GTPase activating protein ARHGAP26:
    • Q05397
  • The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions:
    • Q05397
  • Contains 1 FERM domain.:
    • Q05397
  • Contains 1 protein kinase domain.:
    • Q05397
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.:
    • Q05397
genes like me logo Genes that share domains with PTK2: view

Function for PTK2 Gene

Molecular function for PTK2 Gene

GENATLAS Biochemistry: focal adhesion kinase 1,pp125FAK,widely expressed in T and B lymphocytes,with a splice variant,FAK1A,expressed in brain,primary mediator of integrin signaling after integrin mediated cell adhesion and FAK phosphorylation,also mediating a direct interaction with the C terminal SH2 domain of phospholipase C (PCLG1)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Subject to autoinhibition, mediated by interactions between the FERM domain and the kinase domain. Activated by autophosphorylation at Tyr-397. This promotes interaction with SRC and phosphorylation at Tyr-576 and Tyr-577 in the kinase activation loop. Phosphorylation at Tyr-576 and Tyr-577 is required for maximal kinase activity. Inhibited by TAC544, TAE226, PF-573,228 and PF-562,271.
UniProtKB/Swiss-Prot Function: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

Enzyme Numbers (IUBMB) for PTK2 Gene

Gene Ontology (GO) - Molecular Function for PTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 16803572
GO:0004672 protein kinase activity TAS --
GO:0004713 protein tyrosine kinase activity ISS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA 10655584
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with PTK2: view
genes like me logo Genes that share phenotypes with PTK2: view

Animal Models for PTK2 Gene

MGI Knock Outs for PTK2:

No data available for Transcription Factor Targeting and HOMER Transcription for PTK2 Gene

Localization for PTK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTK2 Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Constituent of focal adhesions. Detected at microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTK2 Gene COMPARTMENTS Subcellular localization image for PTK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 24036928
GO:0005634 nucleus IDA 15855171
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTK2: view

Pathways for PTK2 Gene

genes like me logo Genes that share pathways with PTK2: view

Gene Ontology (GO) - Biological Process for PTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0001525 angiogenesis TAS 20552554
GO:0001568 blood vessel development --
GO:0001570 vasculogenesis IEA --
GO:0001764 neuron migration IEA --
genes like me logo Genes that share ontologies with PTK2: view

Compounds for PTK2 Gene

(4) Tocris Compounds for PTK2 Gene

Compound Action Cas Number
FAK Inhibitor 14 Selective FAK inhibitor [4506-66-5]
PF 431396 Dual FAK/PYK2 inhibitor [717906-29-1]
PF 573228 Potent and selective FAK inhibitor [869288-64-2]
Y 11 Potent and selective FAK inhibitor [1086639-59-9]

(12) HMDB Compounds for PTK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
LPA(0:0/16:0)
  • Lysophosphatidic acid(16:0)
Not Available
LPA(0:0/18:0)
  • 2-octadecanoyl-phosphatidic acid
Not Available
LPA(0:0/18:1(9Z))
  • LPA(18:1)
Not Available

(125) Novoseek inferred chemical compound relationships for PTK2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 89.5 374
phosphotyrosine 78 67
cytochalasin d 73.9 37
phosphatidylinositol 67.2 51
herbimycin a 65.7 11
genes like me logo Genes that share compounds with PTK2: view

Transcripts for PTK2 Gene

Unigene Clusters for PTK2 Gene

Protein tyrosine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - - - - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - - -
SP8: - - -
SP9: - - - - -
SP10:
SP11:
SP12: - - - - - - - - - - - -
SP13: - - -
SP14: - - - - - - - - - - -
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:
SP21:
SP22: -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36a ·
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22:

ExUns: 36b ^ 37 ^ 38a · 38b · 38c ^ 39 ^ 40 ^ 41 ^ 42a · 42b · 42c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21: -
SP22:

Relevant External Links for PTK2 Gene

GeneLoc Exon Structure for
PTK2
ECgene alternative splicing isoforms for
PTK2

Expression for PTK2 Gene

mRNA expression in normal human tissues for PTK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTK2 Gene

SOURCE GeneReport for Unigene cluster for PTK2 Gene Hs.395482

mRNA Expression by UniProt/SwissProt for PTK2 Gene

Q05397-FAK1_HUMAN
Tissue specificity: Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous.
genes like me logo Genes that share expressions with PTK2: view

Orthologs for PTK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTK2 36
  • 99.66 (n)
  • 99.81 (a)
PTK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTK2 36
  • 88.43 (n)
  • 96.29 (a)
PTK2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTK2 36
  • 91.72 (n)
  • 96.9 (a)
PTK2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptk2 36
  • 90.75 (n)
  • 97.34 (a)
Ptk2 16
Ptk2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTK2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTK2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptk2 36
  • 90.87 (n)
  • 96.96 (a)
chicken
(Gallus gallus)
Aves PTK2 36
  • 83.86 (n)
  • 94.86 (a)
PTK2 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTK2 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6819 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ptk2 36
  • 78.27 (n)
  • 90.87 (a)
Str.16767 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4722 36
zebrafish
(Danio rerio)
Actinopterygii ptk2 36
ptk2.2 37
  • 59 (a)
OneToOne
ptk2ab 36
  • 74.12 (n)
  • 83.21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011118 36
  • 48.4 (n)
  • 44.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fak 36
  • 48.81 (n)
  • 42.58 (a)
Fak56D 37
  • 26 (a)
OneToMany
Fak56D 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-32 36
  • 48.08 (n)
  • 36.73 (a)
kin-32 37
  • 30 (a)
OneToMany
kin-32 38
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5720 37
  • 46 (a)
OneToMany
Species with no ortholog for PTK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTK2 Gene

ENSEMBL:
Gene Tree for PTK2 (if available)
TreeFam:
Gene Tree for PTK2 (if available)

Paralogs for PTK2 Gene

Paralogs for PTK2 Gene

genes like me logo Genes that share paralogs with PTK2: view

Variants for PTK2 Gene

Sequence variations from dbSNP and Humsavar for PTK2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3639 -- 140,674,071(+) TCTAT(C/T)ACACT intron-variant
rs7460 -- 140,658,761(-) CAATG(A/T)TATTT utr-variant-3-prime
rs10149 -- 140,658,695(+) GTTNT(G/T)GAACT utr-variant-3-prime
rs12210 -- 140,879,188(+) TGGGA(A/G)CAAAG intron-variant
rs14342 -- 140,658,711(+) TCAAT(C/G)CAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTK2 Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV Deletion 23290073
nsv465952 CNV Loss 19166990
nsv526444 CNV Gain 19592680
nsv891536 CNV Gain 21882294
esv1765152 CNV Insertion 17803354
esv2665041 CNV Deletion 23128226
esv2670372 CNV Deletion 23128226
nsv831482 CNV Loss 17160897
esv1325604 CNV Insertion 17803354
nsv524300 CNV Gain 19592680
nsv8392 CNV Gain 18304495
esv23036 CNV Gain 19812545
nsv438084 CNV Loss 16468122
esv2422061 CNV Duplication 20811451

Relevant External Links for PTK2 Gene

HapMap Linkage Disequilibrium report
PTK2

Disorders for PTK2 Gene

UniProtKB/Swiss-Prot

FAK1_HUMAN
  • Note=Aberrant PTK2/FAK1 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. PTK2/FAK1 overexpression is seen in many types of cancer.

(95) Novoseek inferred disease relationships for PTK2 Gene

Disease -log(P) Hits PubMed IDs
metastasis 62.9 111
tumors 58.5 215
cancer 56.3 145
colon cancer 50.5 48
breast cancer 47.6 87

Relevant External Links for PTK2

Genetic Association Database (GAD)
PTK2
Human Genome Epidemiology (HuGE) Navigator
PTK2
Tumor Gene Database (TGDB):
PTK2
genes like me logo Genes that share disorders with PTK2: view

Publications for PTK2 Gene

  1. Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. (PMID: 7692878) Whitney G.S. … Kanner S.B. (DNA Cell Biol. 1993) 3 4 23
  2. Focal adhesion kinase is upstream of phosphatidylinositol 3- kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. (PMID: 15166238) Xia H. … Henke C.A. (J. Biol. Chem. 2004) 3 4 23
  3. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. (PMID: 15855171) Golubovskaya V.M. … Cance W.G. (J. Biol. Chem. 2005) 3 4 23
  4. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. (PMID: 15895076) Ezratty E.J. … Gundersen G.G. (Nat. Cell Biol. 2005) 3 4 23
  5. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. (PMID: 16452200) Garces C.A. … Cance W.G. (Cancer Res. 2006) 3 4 23

Products for PTK2 Gene

  • Addgene plasmids for PTK2

Sources for PTK2 Gene

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