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PTHLH Gene

protein-coding GIFtS: 63

GC12M028002

parathyroid hormone-like hormone
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HHM ^¹, ²
MGC14611 ^²
PLP ^¹, ²
PTH-rP ^³
PTHR ^¹, ²
PTHRP ^¹, ², ³
PTHrP ^³
osteostatin ^²

Descriptions
PTH-related protein ^²
humoral hypercalcemia of malignancy ^²
parathyroid hormone-like hormone ^²
parathyroid hormone-like protein ^²
parathyroid hormone-like related protein ^²
parathyroid hormone-related protein ^²
parathyroid-like protein ^²

External Ids
HGNC: 9607¹
Entrez Gene: 5744²
UniProtKB: P12272³
Ensembl: ENSG00000087494⁷

Search outside databases for aliases for PTHLH gene

Previous GC identifers: GC12M028487 GC12M028138 GC12M028011 GC12M028006

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PTHLH:

The protein encoded by this gene is a member of the parathyroid hormone family. This hormone

regulates endochondral bone development and epithelial-mesenchymal interactions during the

formation of the mammary glands and teeth. This hormone is involved in lactation possibly by

regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone,

PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively

spliced transcript variants encoding two distinct isoforms have been observed. There is also

evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame

and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.

[provided by RefSeq]

UniProtKB/Swiss-Prot: PTHR_HUMAN, P12272

Function: Osteostatin is a potent inhibitor of osteoclastic bone resorption

Gene Wiki entry for PTHLH (Parathyroid_hormone-related_protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PTHLH gene

Entrez Gene cytogenetic band: 12p12.1-p11.2 Ensembl cytogenetic band: 12p11.22 HGNC cytogenetic band: 12p12.1-p11.2

PTHLH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M028002: (about GC identifiers)

Start:	28,002,284 bp from pter
End:	28,016,183 bp from pter
Size:	13,900 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009714.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PTHR_HUMAN, P12272 (See protein sequence)

Recommended Name: Parathyroid hormone-related protein precursor

Size: 177 amino acids; 20194 Da

Subcellular location: Cytoplasm. Nucleus. Secreted

PDB structures from and Proteopedia :

1BZG (3D)

1ET3 (3D)

1M5N (3D)

3FFD (3D)

Secondary accessions: Q15251

Alternative splicing: 3 isoforms: P12272-1 P12272-2 P12272-3 (Additional isoforms seem to exist)

Post-translational modifications:

There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin

(PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of

these secretory forms is believed to have one or more of its own receptors that mediates the

normal paracrine, autocrine and endocrine actions¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_002811.1 NP_945315.1 NP_945316.1 NP_945317.1

ENSEMBL proteins:

ENSP00000346398 ENSP00000201015 ENSP00000379209 ENSP00000379213

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PTHLH, Parathyroid hormone related protein)
	Human Recombinant Proteins from Abnova (PTHLH)

OriGene Purified Recombinant Human Proteins (see all 3): PTHLH

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	8641188
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	10803599

About this table

Antibodies for PTHLH:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PTHLH
	Sigma-Aldrich Antibodies for PTHLH
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PTHLH, Parathyroid hormone related protein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PTHLH)
	Novus Biologicals Antibodies for PTHLH

Assays for PTHLH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P12272

ProtoNet protein and cluster: P12272

1 Blocks protein family: IPB001415 Parathyroid hormone

UniProtKB/Swiss-Prot: PTHR_HUMAN, P12272

Similarity: Belongs to the parathyroid hormone family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTHLH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTHLH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_198964

Applied Biosystems Silencer® siRNAs for PTHLH

Sigma-Aldrich siRNA and siRNA Panels for PTHLH

Sigma-Aldrich shRNA for PTHLH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PTHLH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_002820
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_002820
untagged cDNA clones in CMV expression vector (see all 5): J03580

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198965

UniProtKB/Swiss-Prot: PTHR_HUMAN, P12272

Function: Neuroendocrine peptide which is a critical regulator of cellular and organ growth,

development, migration, differentiation and survival and of epithelial calcium ion transport.

Regulates endochondral bone development and epithelial-mesenchymal interactions during the

formation of the mammary glands and teeth

Function: Osteostatin is a potent inhibitor of osteoclastic bone resorption

Genatlas biochemistry entry for PTHLH:

parathyroid hormone-like hormone,expressed by pancreatic islet cells,putatively involved in the

regulation of insulin secretion

15/22 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Pthlh) (see all 22 ):

	adipose tissue	behavior/neurological	cellular	craniofacial
digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	TAS	2708388
GO:0005509	calcium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PTHLH

5/47 Interacting proteins for PTHLH (ENSP00000346398³) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IHH	ENSP00000295731³	STRING (score=.998)
PTH1R	ENSP00000324788³	STRING (score=.997)
PTH	ENSP00000282091³	STRING (score=.993)
IL6	ENSP00000258743³	STRING (score=.983)
PTCH1	ENSP00000332353³	STRING (score=.977)

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5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IDA	9008714
GO:0001958	endochondral ossification	IEA	--
GO:0002076	osteoblast development	IEA	--
GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	IDA	9832460
GO:0007267	cell-cell signaling	TAS	2549037

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PTHLH
10/50 Novoseek chemical compound relationships for PTHLH gene (see all 50 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	76.47	710	16006777 (7), 18096456 (6), 8156530 (6), 8018531 (5) (see all 99)
pck-3145	66.95	5	16222145 (3), 15289344 (1)
1,25 dihydroxy vitamin d3	63.12	41	16794368 (4), 8462465 (2), 8359229 (2), 17904173 (2) (see all 24)
cyclic amp	55.95	39	8312363 (3), 8319205 (3), 2108793 (2), 8328312 (2) (see all 25)
forskolin	54.05	27	9175633 (2), 8380405 (2), 10352098 (1), 10548524 (1) (see all 15)
trifluoroethanol	39.10	2	8138348 (1)
ag-1296	37.60	3	15219850 (1), 15336602 (1)
thymidine	36.10	16	11891011 (2), 12230264 (2), 7599071 (1), 11517192 (1) (see all 14)
phosphorus	35.46	11	16160737 (2), 8627105 (1), 7640009 (1), 12683897 (1) (see all 7)
pyridinoline	27.82	1	12794841 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTHLH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTHLH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_198964

Sigma-Aldrich siRNA and siRNA Panels for PTHLH

Sigma-Aldrich shRNA for PTHLH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002820 NM_198964 NM_198965 NM_198966

REFSEQ mRNAs for PTHLH gene (4 alternative transcripts):

NM_002820.2 NM_198964.1 NM_198965.1 NM_198966.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002820 NM_198964 NM_198965 NM_198966

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_002820
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_002820
                                 untagged cDNA clones in CMV expression vector (see all 5): J03580

Additional cDNA sequence:

AK313476.1 BC005961.1 BT007178.1 CR541882.1 J03580.1 J03802.1 M26958.1 M26959.1

9 DOTS entries:

DT.40297109 DT.100745590 DT.101979164 DT.91712557 DT.95270704 DT.95270703 DT.121164115 DT.121164170

DT.95270705

24/62 AceView cDNA sequences (see all 62 ):

AA453402 CR541882 NM_002820 NM_198966 BF155666 BG680355 CK903432 BF447014

M34071 NM_198965 BI963162 NM_198964 AA158170 AA845432 AA374372 BG678818

BG676028 BG680295 AW845113 AI784672 BG679319 CF454324 BT007178 BM924176

highest scoring ESTs for PTHLH:

BC005961 BF541944 BG678065 BG678818 BG680295 BG680355 BI752853 J03802 M26959 AA131693

Unigene Cluster for PTHLH:

Parathyroid hormone-like hormone

Hs.591159 [show with all ESTs]

Unigene Representative Sequence: J03580

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for PTHLH

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8
SP1:					-		-						-
SP2:													-										-
SP3:							-						-
SP4:

About this scheme

ECgene alternative splicing isoforms for PTHLH

4 Ensembl transcripts including schematic representations:

ENST00000354417 ENST00000201015 ENST00000395868 ENST00000395872

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PTHLH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PTHLH

¹ / ² / ³

8 probe-sets matching PTHLH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
615_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M24351	0.20	1.00	0.72	1
37989_at²^{, 3}	U95-A	1	1.00	1.00	0.62	0.52	J03802	0.80	1.00	0.91	1
211756_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005961	0.80	1.00	0.91	1
206300_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002820	0.60	1.00	0.82	1
210355_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J03580	0.60	1.00	0.82	1
211756_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206300_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210355_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAAAATAAC

SOURCE GeneReport for Unigene cluster: Hs.591159
Expression variation in blood from EXPOLDB for PTHLH
UniProtKB/Swiss-Prot: PTHR_HUMAN, P12272
Tissue specificity: Ubiquitous. Also expressed in the mammary gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PTHLH gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PTHLH¹	--	parathyroid hormone-like hormone	90.77(n) 91.53(a)	403987 NM_001003303.1 NP_001003303.1
chimpanzee (Pan troglodytes)	PTHLH¹	--	parathyroid hormone-like hormone	100(n) 100(a)	473393 XM_001142021.1 XP_001142021.1
cow (Bos taurus)	PTHLH¹	--	parathyroid hormone-like hormone	89.46(n) 90.8(a)	286767 NM_174753.1 NP_777178.1
rat (Rattus norvegicus)	Pthlh¹	--	parathyroid hormone-like hormone	83.33(n) 90.8(a)	24695 NM_012636.1 NP_036768.1
mouse (Mus musculus)	Pthlh^{1, 5}	6 (74.00 cM)⁵	parathyroid hormone-like peptide^{1, 5}	83.62(n)¹ 87.43(a)¹	19227¹ NM_008970.1¹ NP_032996.1¹ AJ278119⁵ AW540230⁵ (see all 17)

About this table Species with no ortholog for PTHLH

ENSEMBL Gene Tree for PTHLH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/131 NCBI SNPs in PTHLH are shown (see all 131 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 71)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs39635^1,2	A,C,F,H,O	28017512(-)	`AGGAGG/TAAAGA`	2	--	ng3¹ trp³		4	EU EA WA	416
	rs6252^1,2	A,C,F,H	28002340(+)	`TACTGT/CTATTT`	2	--	ut3¹		5	MN EU EA WA	504
	rs10843041^1,2	A,C,F,H	28001871(+)	`ATATCG/ATTGTT`	2	--	ng5¹		7	EU EA WA NA	542
	rs27633^1,2	A,C,F,H	28015572(-)	`TGGGGA/CGGGTA`	4	--	ng3¹ int¹ tfbs³		5	EU EA WA	1284
	rs26303^1,2	A,C,F,H	28015097(-)	`TAGCCG/CATGCT`	4	--	int¹ ng3¹ ese³		5	MN EU EA WA	592
	rs6246^1,2	A,C,F	28014160(-)	`GGGCCT/CGGTTC`	4	--	ut5¹ int¹		5	MN EA NA	1632
	rs2796^1,2	C,F,H	28007378(-)	`AAGCAG/ATACCC`	4	--	int¹ ut3¹		7	MN EU EA WA	2114
	rs6245^1,2	C,F,H	28007324(-)	`CTAGAG/ACCCAT`	4	--	ut3¹ int¹		2	MN EU	142
	rs6253^1,2	A,C,F	28007208(-)	`AGTGTG/ATTTCT`	4	--	int¹ ut3¹		4	MN EA NA	1768
	rs6248^1,2	C,F,H	28006083(-)	`TTTCCT/CTTGAC`	4	--	int¹ ng5¹		11	MN EU EA WA	2588

About this table

HapMap Linkage Disequilibrium images for PTHLH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 168470

UniProtKB/Swiss-Prot: PTHR_HUMAN, P12272

Produced by many tumors from patients with HHM (humoral hypercalcemia of malignancy)

10/94 Novoseek disease relationships for PTHLH gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypercalcemia	96.72	1412	1424212 (6), 8453901 (6), 10660809 (6), 1434529 (5) (see all 99)
osteolytic	84.04	92	8833902 (4), 16813525 (3), 10898330 (3), 7754638 (2) (see all 51)
bone metastases	81.81	137	1782489 (7), 10861577 (7), 19139120 (5), 11741801 (5) (see all 50)
paraneoplastic syndromes	77.81	25	11911944 (1), 14613038 (1), 16022632 (1), 7768974 (1) (see all 17)
hyperparathyroidism primary	72.66	25	1424212 (2), 1449040 (2), 2056982 (2), 8060769 (2) (see all 18)
osteolysis	72.45	33	10898332 (2), 11701443 (2), 11996903 (2), 16885353 (2) (see all 21)
bone destruction	70.76	21	9362422 (2), 9362421 (1), 10548524 (1), 8833902 (1) (see all 17)
tumors	60.72	741	11893937 (7), 7754638 (6), 2293655 (6), 8004587 (6) (see all 99)
pseudohypoparathyroidism, type ib	60.33	1	9100569 (1)
metastasis	59.53	225	9362424 (8), 14696114 (5), 8003863 (5), 8752176 (4) (see all 99)

About this table

Human Gene Mutation Database: PTHLH
Human Genome Epidemiology Navigator: PTHLH (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1088 PubMed articles for PTHLH gene (see all 1088 ):

Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects. (PubMed id 2708388)^{2, 3, 4} Yasuda T.... Goltzman D. (1989)
Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles. (PubMed id 12852260)^{1, 3, 4} Jans D.A.... Gillespie M.T. (2003)
Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein. (PubMed id 11401507)^{1, 3, 4} Lam M.H.... Jans D.A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Minireview: parathyroid hormone-related protein as an intracrine factor -- trafficking mechanisms and functional consequences. (PubMed id 12538599)^{3, 4} Fiaschi-Taesch N.M. and Stewart A.F. (2003)
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. (PubMed id 12504010)^{3, 4} Cingolani G.... Gerace L. (2002)
The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution. (PubMed id 10050767)^{3, 4} Weidler M....Rosch P. (1999)
C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells. (PubMed id 9144344)^{3, 4} Martinez M.E.... Esbrit P. (1997)
Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo. (PubMed id 9048639)^{3, 4} Cornish J.... Reid I.R. (1997)
A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP107-111. (PubMed id 1954916)^{3, 4} Fenton A.J.... Nicholson G.C. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5744	HGNC: 9607	AceView: PTHLH	Ensembl:ENSG00000087494	euGenes: HUgn5744
ECgene: PTHLH	H-InvDB: PTHLH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PTHLH	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PTHLH
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PTHLH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PTHLH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PTHLH		Antibodies for PTHLH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PTHLH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PTHLH)
	Antibodies (PTHLH)
	Chimera RNAi (PTHLH)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PTHLH, Parathyroid hormone related protein)
	Antibodies (PTHLH, Parathyroid hormone related protein)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for PTHLH

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PTHLH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PTHLH Gene at Home site.
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PTHLH Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for PTHLH

Summaries
for PTHLH

Genomic Location
for PTHLH

Proteins
for PTHLH

Protein Domains/
Families
for PTHLH

Gene Function
for PTHLH

Pathways & Interactions
for PTHLH

Drugs & Compounds
for PTHLH

Transcripts
for PTHLH

Expression
for PTHLH

Orthologs
for PTHLH

Paralogs
for PTHLH

SNPs/Variants
for PTHLH

Disorders & Mutations
for PTHLH

Medical News
for PTHLH

Publications
for PTHLH

Search for PTHLH

Genome Databases showing PTHLH

Other Databases showing PTHLH

Specialized Databases showing PTHLH

Licensable Technologies
for PTHLH

Services
for PTHLH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PTHLH Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor PTHLH

Summariesfor PTHLH

Genomic Locationfor PTHLH

Proteinsfor PTHLH

Protein Domains/Familiesfor PTHLH

Gene Functionfor PTHLH

Pathways & Interactionsfor PTHLH

Drugs & Compoundsfor PTHLH

Transcriptsfor PTHLH

Expression for PTHLH

Orthologsfor PTHLH

Paralogsfor PTHLH

SNPs/Variantsfor PTHLH

Disorders & Mutationsfor PTHLH

Medical Newsfor PTHLH

Publicationsfor PTHLH

Search for PTHLH

Genome Databases showing PTHLH

Other Databases showing PTHLH

Specialized Databases showing PTHLH

Licensable Technologiesfor PTHLH

Servicesfor PTHLH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PTHLH

Summaries
for PTHLH

Genomic Location
for PTHLH

Proteins
for PTHLH

Protein Domains/
Families
for PTHLH

Gene Function
for PTHLH

Pathways & Interactions
for PTHLH

Drugs & Compounds
for PTHLH

Transcripts
for PTHLH

Expression
for PTHLH

Orthologs
for PTHLH

Paralogs
for PTHLH

SNPs/Variants
for PTHLH

Disorders & Mutations
for PTHLH

Medical News
for PTHLH

Publications
for PTHLH

Licensable Technologies
for PTHLH

Services
for PTHLH