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Aliases for PTH2R Gene

Aliases for PTH2R Gene

  • Parathyroid Hormone 2 Receptor 2 3
  • PTHR2 3 4 6
  • Parathyroid Hormone Receptor 2 2 3
  • PTH2 Receptor 3 4

External Ids for PTH2R Gene

Previous HGNC Symbols for PTH2R Gene

  • PTHR2

Previous GeneCards Identifiers for PTH2R Gene

  • GC02P208980
  • GC02P209224
  • GC02P201118

Summaries for PTH2R Gene

Entrez Gene Summary for PTH2R Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for PTH2R Gene

PTH2R (Parathyroid Hormone 2 Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include parathyroid hormone receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for PTH2R Gene

  • This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).

Gene Wiki entry for PTH2R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTH2R Gene

Genomics for PTH2R Gene

Regulatory Elements for PTH2R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTH2R Gene

Start:
208,359,714 bp from pter
End:
208,854,503 bp from pter
Size:
494,790 bases
Orientation:
Plus strand

Genomic View for PTH2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTH2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTH2R Gene

Proteins for PTH2R Gene

  • Protein details for PTH2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49190-PTH2R_HUMAN
    Recommended name:
    Parathyroid hormone 2 receptor
    Protein Accession:
    P49190
    Secondary Accessions:
    • Q8N429

    Protein attributes for PTH2R Gene

    Size:
    550 amino acids
    Molecular mass:
    62236 Da
    Quaternary structure:
    • Binds to TIPF39/TIP39

neXtProt entry for PTH2R Gene

Proteomics data for PTH2R Gene at MOPED

Post-translational modifications for PTH2R Gene

  • Glycosylation at Asn51, Asn106, Asn116, and Asn121
  • Modification sites at PhosphoSitePlus

Other Protein References for PTH2R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTH2R Gene

Domains for PTH2R Gene

Gene Families for PTH2R Gene

HGNC:
  • PTHNR :GPCR / Class B : Parathyroid hormone receptors
IUPHAR :

Suggested Antigen Peptide Sequences for PTH2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49190

UniProtKB/Swiss-Prot:

PTH2R_HUMAN :
  • P49190
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with PTH2R: view

Function for PTH2R Gene

Molecular function for PTH2R Gene

UniProtKB/Swiss-Prot Function: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).

Gene Ontology (GO) - Molecular Function for PTH2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0004991 parathyroid hormone receptor activity TAS 7797535
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PTH2R: view

Phenotypes for PTH2R Gene

MGI mutant phenotypes for PTH2R:
inferred from 1 alleles
GenomeRNAi human phenotypes for PTH2R:
genes like me logo Genes that share phenotypes with PTH2R: view

Animal Model Products

miRNA for PTH2R Gene

miRTarBase miRNAs that target PTH2R

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTH2R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PTH2R Gene

Localization for PTH2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTH2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTH2R Gene COMPARTMENTS Subcellular localization image for PTH2R gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for PTH2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7797535
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PTH2R: view

Pathways for PTH2R Gene

genes like me logo Genes that share pathways with PTH2R: view

Pathways by source for PTH2R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTH2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PTH2R: view

Compounds for PTH2R Gene

(26) IUPHAR Ligand for PTH2R Gene

Ligand Type Action Affinity Pubmed IDs
TIP39-(7-39) (mouse) Antagonist Antagonist 8.2
TIP39-(7-39) (human/bovine) Antagonist Antagonist 8.2
[125I][Nle8,21,Tyr34]PTH-(1-34)-NH2 (rat) Agonist Full agonist 8
[Ile5,Trp23]PTHrP-(1-36) (human) Agonist Full agonist 7.8
[Ile5,Trp23]PTHrP-(3-36) (human) Agonist Full agonist 7.8
PTHrP-(1-21)/PTH-(22-34) (human) Agonist Full agonist 7.7
[Ile5,Trp23]PTHrP-(2-36) (human) Agonist Full agonist 7.6
[Ile5,Trp23,Tyr36]PTHrP-(1-36)-NH2 (human) Agonist Full agonist 7.5
PTH-(1-34) (human) Agonist Full agonist 7.4
[D-Trp12,Tyr34]PTH-(7-34) (bovine) Antagonist Antagonist 7.4
[Ile5,Trp23]PTHrP-(4-36) (human) Agonist Full agonist 7.4
TIP39-(9-39) (human/bovine) Antagonist Antagonist 7.4
[Trp23]PTHrP-(1-36) (human) Agonist Full agonist 7.3
PTH-(1-34) (rat) Agonist Full agonist 7.2
TIP39 Antagonist Antagonist 7.2
TIP39 Antagonist Antagonist 7.2
PTHrP-(7-34) (human, rat, mouse) Antagonist Antagonist 7.2
[Trp23,Tyr36]PTHrP-(1-36)-NH2 (human) Agonist Full agonist 7
[Ile5,Trp23]PTHrP-(5-36) (human) Agonist Full agonist 7
[Ile5,Trp23]PTHrP-(5-36) Antagonist Antagonist 7
[Phe23]PTH-(1-34) (human) Agonist Full agonist 7
PTHrP-(1-36) Agonist Full agonist 6.5
[Ile5]PTHrP-(1-36) Agonist Full agonist 6.2
PTHrP-(1-34) Agonist Full agonist 6.1
[His5]PTH-(1-34) (human) Agonist Full agonist 5.3
[D-Trp12]PTH-(7-34) (bovine) Antagonist Antagonist

(1) Novoseek inferred chemical compound relationships for PTH2R Gene

Compound -log(P) Hits PubMed IDs
calcium 18.8 1
genes like me logo Genes that share compounds with PTH2R: view

Transcripts for PTH2R Gene

mRNA/cDNA for PTH2R Gene

Unigene Clusters for PTH2R Gene

Parathyroid hormone 2 receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTH2R

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTH2R Gene

No ASD Table

Relevant External Links for PTH2R Gene

GeneLoc Exon Structure for
PTH2R
ECgene alternative splicing isoforms for
PTH2R

Expression for PTH2R Gene

mRNA expression in normal human tissues for PTH2R Gene

mRNA differential expression in normal tissues according to GTEx for PTH2R Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.1), Kidney - Cortex (8.9), Brain - Cortex (6.7), and Brain - Amygdala (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTH2R Gene

SOURCE GeneReport for Unigene cluster for PTH2R Gene Hs.570296

mRNA Expression by UniProt/SwissProt for PTH2R Gene

P49190-PTH2R_HUMAN
Tissue specificity: Expressed abundantly in brain and pancreas. Also expressed in the testis.
genes like me logo Genes that share expressions with PTH2R: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PTH2R Gene

Orthologs for PTH2R Gene

This gene was present in the common ancestor of animals.

Orthologs for PTH2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTH2R 35
  • 99.27 (n)
  • 99.27 (a)
PTH2R 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTH2R 35
  • 88.55 (n)
  • 89.09 (a)
PTH2R 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTH2R 35
  • 86.1 (n)
  • 83.76 (a)
PTH2R 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pth2r 35
  • 84.31 (n)
  • 83.52 (a)
Pth2r 16
Pth2r 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTH2R 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTH2R 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pth2r 35
  • 83.52 (n)
  • 82.07 (a)
chicken
(Gallus gallus)
Aves PTH3R 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia PTH2R 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pth2r 35
  • 71 (n)
  • 73.84 (a)
zebrafish
(Danio rerio)
Actinopterygii pth2r 35
  • 65.62 (n)
  • 65.49 (a)
pth2r 36
  • 58 (a)
OneToMany
PTH2R (2 of 2) 36
  • 62 (a)
OneToMany
pthr2 35
fruit fly
(Drosophila melanogaster)
Insecta Dh44-R1 36
  • 26 (a)
ManyToMany
Dh44-R2 36
  • 25 (a)
ManyToMany
Species with no ortholog for PTH2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTH2R Gene

ENSEMBL:
Gene Tree for PTH2R (if available)
TreeFam:
Gene Tree for PTH2R (if available)

Paralogs for PTH2R Gene

Selected SIMAP similar genes for PTH2R Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTH2R: view

Variants for PTH2R Gene

Sequence variations from dbSNP and Humsavar for PTH2R Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs717575 -- 208,385,603(-) GAATT(A/G)CAGCA intron-variant
rs879707 -- 208,470,253(+) TGTAA(A/G)TATTT intron-variant
rs897081 -- 208,475,187(+) GTGAA(A/T)ATGCA intron-variant
rs897082 -- 208,475,188(+) TGAAA(A/G)TGCAA intron-variant
rs897083 -- 208,477,369(+) GTCTC(A/G)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTH2R Gene

Variant ID Type Subtype PubMed ID
nsv3138 CNV Insertion 18451855
esv2666372 CNV Deletion 23128226

Relevant External Links for PTH2R Gene

HapMap Linkage Disequilibrium report
PTH2R
Human Gene Mutation Database (HGMD)
PTH2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTH2R Gene

Disorders for PTH2R Gene

Relevant External Links for PTH2R

Genetic Association Database (GAD)
PTH2R
Human Genome Epidemiology (HuGE) Navigator
PTH2R
genes like me logo Genes that share disorders with PTH2R: view

No data available for UniProtKB/Swiss-Prot for PTH2R Gene

Publications for PTH2R Gene

  1. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. (PMID: 7797535) Usdin T.B. … Bonner T.I. (J. Biol. Chem. 1995) 3 4 23
  2. Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. (PMID: 8921382) Usdin T.B. … Bonner T.I. (Genomics 1996) 3 4 23
  3. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. (PMID: 11861531) John M.R. … Jueppner H. (Endocrinology 2002) 3 4 23
  4. Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes. (PMID: 18280230) Tenne M. … Akesson K. (Bone 2008) 3 23 48
  5. Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem. (PMID: 18459453) BagA^ A.G. … Dobolyi A. (Ideggyogy Sz 2008) 3 23

Products for PTH2R Gene

Sources for PTH2R Gene

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