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PTH2R Gene

protein-coding   GIFtS: 61
GCID: GC02P209224

Parathyroid Hormone 2 Receptor

(Previous name: parathyroid hormone receptor 2)
(Previous symbol: PTHR2)
  See PTH2R-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Parathyroid Hormone 2 Receptor1 2
PTHR21 2 3 5
Parathyroid Hormone Receptor 21 2
PTH2 Receptor2 3

External Ids:    HGNC: 96091   Entrez Gene: 57462   Ensembl: ENSG000001444077   OMIM: 6014695   UniProtKB: P491903   

Export aliases for PTH2R gene to outside databases

Previous GC identifers: GC02P208980 GC02P201118


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTH2R Gene:
The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a
receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more
specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and
not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for PTH2R Gene:
PTH2R (parathyroid hormone 2 receptor) is a protein-coding gene. Diseases associated with PTH2R include jansen's metaphyseal chondrodysplasia. GO annotations related to this gene include parathyroid hormone receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: PTH2R_HUMAN, P49190
Function: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G
proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological
systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may
function as a neurotransmitter receptor (By similarity)

summary for PTH2R Gene:
Parathyroid hormone (PTH) receptors are a group of Gs-protein-coupled receptors, currently divided into two
subtypes; PTH1 and PTH2. Each subtype has a distinct distribution and mediates different biological actions.
PTH1 is ubiquitously expressed, but is found at particularly high levels in skeletal muscle and the kidneys.
PTH1 is involved in calcium and phosphate homeostasis and has a role in chondrocyte regulation. PTH2
expression is limited to the brain and testes. Its actions are proposed to include nociception and
regulation of pituitary hormone secretion. The human genes encoding the PTH1 and PTH2 receptors are located
on chromosomes 3p22-21.1 and 2q33 respectively.

Gene Wiki entry for PTH2R (Parathyroid hormone 2 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTH2R gene promoter:
         TBP   Sox5   CUTL1   MEF-2A   Pax-3   CBF-A   CBF-B   aMEF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTH2R promoter sequence
   Search Chromatin IP Primers for PTH2R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTH2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q33

PTH2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTH2R gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P209224:  view genomic region     (about GC identifiers)

Start:
209,224,438 bp from pter      End:
209,719,227 bp from pter
Size:
494,790 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTH2R_HUMAN, P49190 (See protein sequence)
Recommended Name: Parathyroid hormone 2 receptor precursor  
Size: 550 amino acids; 62236 Da
Subunit: Binds to TIPF39/TIP39
Secondary accessions: Q8N429

Explore the universe of human proteins at neXtProt for PTH2R: NX_P49190

Explore proteomics data for PTH2R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51, Asn106, Asn116, Asn121
  • Modification sites at PhosphoSitePlus

  • See PTH2R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005039.1  
    ENSEMBL proteins: 
     ENSP00000272847   ENSP00000393930  
    Reactome Protein details: P49190

    PTH2R Human Recombinant Protein Products:

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    antibodies-online kits for PTH2R (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTHNR: GPCR / Class B : Parathyroid hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PTH2 receptor
    Parathyroid hormone receptors

    4 InterPro protein domains:
     IPR001879 GPCR_2_extracellular_dom
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P49190

    ProtoNet protein and cluster: P49190

    1 Blocks protein domain: IPB000832 G-protein coupled receptors family 2 (secretin-like)

    UniProtKB/Swiss-Prot: PTH2R_HUMAN, P49190
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Find genes that share domains with PTH2R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTH2R_HUMAN, P49190
    Function: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G
    proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological
    systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may
    function as a neurotransmitter receptor (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004991parathyroid hormone receptor activity TAS7797535
         
    Find genes that share ontologies with PTH2R           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PTH2R:
     Increased S DNA content, incre 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pth2r):
     no phenotypic analysis 

    Find genes that share phenotypes with PTH2R           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PTH2R

    miRNA
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    miRTarBase miRNAs that target PTH2R:
    hsa-mir-124-3p (MIRT022285)

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    1 qRT-PCR Assays for microRNA that regulate PTH2R:
    hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidPTH2R 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTH2R_HUMAN, P49190: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7797535
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with PTH2R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTH2R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like
    5G alpha (s) signalling events
    G alpha (s) signalling events


    Find genes that share SuperPaths with PTH2R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PTH2R
        GPCRs, Class B Secretin-like

    2 Reactome Pathways for PTH2R
        G alpha (s) signalling events
    Class B/2 (Secretin family receptors)


    1 Kegg Pathway  (Kegg details for PTH2R):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including PTH2R: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTH2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTH2R (P491902, 3 ENSP000002728474) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51635 I2D: score=3 
    CALM3P621582, 3MINT-51635 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51635 I2D: score=3 STRING: ENSP00000349467
    PTHP012703, ENSP000002820914I2D: score=2 STRING: ENSP00000282091
    PTH2Q96A983, ENSP000002706314I2D: score=1 STRING: ENSP00000270631
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS7797535

    Find genes that share ontologies with PTH2R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PTH2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Parathyroid hormone (1-34) (human)Parathyroid hormone (PTH) receptor agonist[52232-67-4]

    Selected IUPHAR Ligands for PTH2R (PTH2 receptor) (see all 26)    About this table
    LigandTypeActionAffinityPubmed IDs
    PTH-(1-34) (rat)
    AgonistFull agonist7.2 - 9.511602681 10537121 10854439
    TIP39
    AgonistFull agonist7.6 - 9.211602681 10854439
    TIP39
    AgonistFull agonist8.811602681
    TIP39-(7-39) (mouse)
    AntagonistAntagonist8.211602681
    [125I][Nle8,21,Tyr34]PTH-(1-34)-NH2 (rat)
    AgonistFull agonist8.19360953
    PTHrP-(1-21)/PTH-(22-34) (human)
    AntagonistAntagonist7 - 88702701 11602681
    [Ile5,Trp23]PTHrP-(1-36) (human)
    AgonistFull agonist7.1 - 88702701 10537121
    PTH-(1-34) (human)
    AgonistFull agonist7.7 - 7.88702701 11602681
    [Ile5,Trp23,Tyr36]PTHrP-(1-36)-NH2 (human)
    AgonistFull agonist7.79360953
    [Trp23]PTHrP-(1-36) (human)
    AgonistFull agonist7.58702701

    1 Novoseek inferred chemical compound relationship for PTH2R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 18.8 1 12529938 (1)



    Find genes that share compounds with PTH2R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTH2R gene: 
    NM_005048.3  

    Unigene Cluster for PTH2R:

    Parathyroid hormone 2 receptor
    Hs.570296  [show with all ESTs]
    Unigene Representative Sequence: NR_073601
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413482 ENST00000272847(uc010zjb.2 uc002vdb.3) ENST00000419079(uc010fuo.1)
    ENST00000487472
    miRNA
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    Additional mRNA sequence: 

    AK294181.1 AK309827.1 AY497546.1 BC036811.1 NR_073601.1 U25128.1 

    3 DOTS entries:

    DT.404030  DT.121010025  DT.100686538 

    16 AceView cDNA sequences:

    NM_005048 BC036811 CR617338 AL527631 AY497546 U25128 BU676094 BM808818 
    BM662901 AL120953 AI655036 BQ231022 AL043796 AA223069 BF155763 AL162097 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTH2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGATCAAT
    PTH2R Expression
    About this image

    PTH2R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTH2R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.570296

    UniProtKB/Swiss-Prot: PTH2R_HUMAN, P49190
    Tissue specificity: Expressed abundantly in brain and pancreas. Also expressed in the testis

        Pathway & Disease-focused RT2 Profiler PCR Array including PTH2R: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PTH2R gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pth2r1 , 5 parathyroid hormone 2 receptor1, 5 84.31(n)1
    83.52(a)1
      1 (33.05 cM)5
    2135271  NM_139270.21  NP_644676.11 
     652820565 
    chicken
    (Gallus gallus)
    Aves PTH3R6
    Uncharacterized protein
    48(a)
    many ↔ many
    27(2822027-2826383) ENSGALG00000019797
    lizard
    (Anolis carolinensis)
    Reptilia PTH2R6
    parathyroid hormone 2 receptor
    74(a)
    1 ↔ 1
    4(90298442-90347855)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pth2r1 parathyroid hormone 2 receptor 71(n)
    73.84(a)
      100488565  XM_002937118.2  XP_002937164.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pthr22 parathyroid hormone receptor 2 77.13(n)   30650  AF132082.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dh44-R16
    Dh44-R26
    Diuretic hormone 44 receptor 2
    26(a)
    25(a)
    many ↔ many
    many ↔ many
    2R(10265630-10272864)
    2R(8361949-8375491)


    ENSEMBL Gene Tree for PTH2R (if available)
    TreeFam Gene Tree for PTH2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTH2R gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    11 SIMAP similar genes for PTH2R using alignment to 2 protein entries:     PTH2R_HUMAN (see all proteins):
    PTHR2    PTH1R    VIPR2    GCGR    SCTR    GLP2R
    VIPR1    CALCR    GHRHR    GIPR    GLP1R

    Find genes that share paralogs with PTH2R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTH2R (see all 2415)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021186721,2
    C--209224020(+) CAGAA-/AGCAGCCA 1 -- us2k10--------
    rs1907092801,2
    --209224042(+) GCTTTC/GAATTT 1 -- us2k10--------
    rs1147166671,2
    C,F--209224062(+) CATGCA/GGAAAA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1453097321,2
    --209224106(+) TCCTTC/TTGTTA 1 -- us2k10--------
    rs1380317491,2
    --209224107(+) CCTTTC/TGTTAC 1 -- us2k10--------
    rs1149282961,2
    F--209224152(+) TAGTTC/GTAGAA 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1820262541,2
    C--209224207(+) TGCCTC/TACCTG 1 -- us2k10--------
    rs1391413871,2
    C--209224229(+) TCGCT-/TTC   
      TGTTCA
    TTCTG
    1 -- us2k10--------
    rs1858268541,2
    --209224239(+) TTCATC/TCTGTT 1 -- us2k10--------
    rs1425098241,2
    --209224265(+) TGTTTA/CACCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTH2R (209224438 - 209474438 bp, first 250kb of PTH2R)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PTH2R:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666372CNV Deletion23128226
    nsv3138CNV Insertion18451855

    Human Gene Mutation Database (HGMD): PTH2R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTH2R
    DNA2.0 Custom Variant and Variant Library Synthesis for PTH2R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601469    OMIM disorders: --

    1 disease for PTH2R:    
    About MalaCards
    jansen's metaphyseal chondrodysplasia


    Find genes that share disorders with PTH2R           About GenesLikeMe

    Genetic Association Database (GAD): PTH2R
    Human Genome Epidemiology (HuGE) Navigator: PTH2R (1 document)

    Export disorders for PTH2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTH2R gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with PTH2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes. (PubMed id 18280230)1, 4, 9 Tenne M....Akesson K. (Bone 2008)
    2. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. (PubMed id 7797535)1, 2, 9 Usdin T.B.... Bonner T.I. (J. Biol. Chem. 1995)
    3. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. (PubMed id 11861531)1, 2, 9 John M.R.... Jueppner H. (Endocrinology 2002)
    4. Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. (PubMed id 8921382)1, 2, 9 Usdin T.B.... Bonner T.I. (Genomics 1996)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism. (PubMed id 12834174)1, 9 Seeliger S....Kosch M. (Clin. Nephrol. 2003)
    7. Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. (PubMed id 10854439)1, 9 Hoare S.R....Usdin T.B. (J. Biol. Chem. 2000)
    8. Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. (PubMed id 9482662)1, 9 Clark J.A....Usdin T.B. (Mol. Endocrinol. 1998)
    9. Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. (PubMed id 19401215)1, 9 BagA^ A.G....Dobolyi A. (Neuroscience 2009)
    10. Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem. (PubMed id 18459453)1, 9 BagA^ A.G....Dobolyi A. (Ideggyogy Sz 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5746 HGNC: 9609 AceView: PTHR2 Ensembl:ENSG00000144407 euGenes: HUgn5746
    ECgene: PTH2R Kegg: 5746 H-InvDB: PTH2R

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PTH2R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PTH2R gene:
    Search GeneIP for patents involving PTH2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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