Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTH1R Gene

protein-coding GIFtS: 65
GCID: GC03P046895

parathyroid hormone 1 receptor

(Previous name: parathyroid hormone receptor 1 )
(Previous symbols: PTHR, PTHR1)

Explore 68 diseases affiliated with
PTH1R via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Parathyroid Hormone 1 Receptor¹ ² ³		PTH1 Receptor² ³
PTHR¹ ² ³ ⁵		PFE² ⁵
PTHR1¹ ² ³ ⁵		Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor²
Parathyroid Hormone Receptor 1¹ ²		Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor²
PTH/PTHr Receptor² ³		Seven Transmembrane Helix Receptor²
PTH/PTHrP Type I Receptor² ³

External Ids:	HGNC: 9608¹	Entrez Gene: 5745²	Ensembl: ENSG00000160801⁷	OMIM: 168468⁵	UniProtKB: Q03431³

Export aliases for PTH1R gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTH1R:

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for

parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated

by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects

in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand

type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this

gene. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: PTH1R_HUMAN, Q03431

Function: This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this

receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second

messenger system

Gene Wiki entry for PTH1R (Parathyroid hormone 1 receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTH1R gene promoter:
CREB PPAR-gamma1 p53 deltaCREB PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTH1R promoter sequence

Search SABiosciences Chromatin IP Primers for PTH1R

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTH1R

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21.1 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p22-p21.1

PTH1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTH1R gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P046895: view genomic region (about GC identifiers)

Start:	46,919,236 bp from pter	End:	46,945,289 bp from pter
Size:	26,054 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PTH1R_HUMAN, Q03431 (See protein sequence)

Recommended Name: Parathyroid hormone/parathyroid hormone-related peptide receptor precursor

Size: 593 amino acids; 66361 Da

Subunit: Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand.

Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed

by GNG2 and GNB1

Subcellular location: Cell membrane; Multi-pass membrane protein

6/7 PDB 3D structures from and Proteopedia for PTH1R (see all 7):

1BL1 (3D)

1ET2 (3D)

1ET3 (3D)

3C4M (3D)

3H3G (3D)

3KJ5 (3D)

Secondary accessions: Q2M1U3

Explore the universe of human proteins at neXtProt for PTH1R: NX_Q03431

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q03431

PTH1R Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000307.1 NP_001171673.1

ENSEMBL proteins:

ENSP00000402723 ENSP00000411424 ENSP00000400977 ENSP00000321999 ENSP00000389811

ENSP00000396176 ENSP00000413774

Reactome Protein details: Q03431
Human Recombinant Protein Products for PTH1R:

	EMD Millipore Purified and/or Recombinant PTH1R Protein
	R&D Systems Recombinant & Natural Proteins for PTH1R (PTH1R/PTHR1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PTH1R OriGene Custom Protein Services for PTH1R
	GenScript Custom Purified and Recombinant Proteins Services for PTH1R
	Novus Biologicals PTH1R Protein Novus Biologicals PTH1R Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTH1R

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	19674967

PTH1R for ontologies About GeneDecksing

PTH1R Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PTH1R (PTH1R/PTHR1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for PTH1R
	GenScript Custom Superior Antibodies Services for PTH1R
	Novus Biologicals PTH1R Antibodies
	Abcam antibodies for PTH1R
	Uscn Antibodies for PTH1R
	ThermoFisher Antibody for PTH1R

Assay Products for PTH1R:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript PTH1R-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTH1R

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTH1R for domains About GeneDecksing

5 InterPro domains/families:

IPR002170 GPCR_2_parathyroid_rcpt

IPR001879 GPCR_2_extracellular_dom

IPR000832 GPCR_2_secretin-like

IPR017983 GPCR_2_secretin-like_CS

IPR017981 GPCR_2-like

Graphical View of Domain Structure for InterPro Entry Q03431

ProtoNet protein and cluster: Q03431

2 Blocks protein families:

IPB000832 G-protein coupled receptors family 2 (secretin-like)

IPB002170 Parathyroid hormone receptor signature

UniProtKB/Swiss-Prot: PTH1R_HUMAN, Q03431

Similarity: Belongs to the G-protein coupled receptor 2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PTH1R_HUMAN, Q03431

Function: This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this

receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second

messenger system

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004991	parathyroid hormone receptor activity	IDA	19674967
GO:0017046	peptide hormone binding	IDA	19674967
GO:0043621	protein self-association	IDA	19674967

PTH1R for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Pth1r):

craniofacial	digestive/alimentary	embryogenesis	growth/size	homeostasis/metabolism
limbs/digits/tail	mortality/aging	respiratory system	skeleton

PTH1R for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PTH1R: Pth1r^tm4Hmk Pth1r^tm3Hmk Pth1r^tm1Abas Pth1r^tm1Hmk

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PTH1R

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTH1R
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate PTH1R:
		hsa-miR-125a-5p hsa-miR-125b hsa-miR-133a hsa-miR-133b hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: PTH1R 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTH1R (see all 4) OriGene shRNA RFP: PTH1R OriGene siRNA: PTH1R
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTH1R
		Sirion Biotech Custom design and validation of potent shRNA sequences against PTH1R

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PTH1R
			Sirion Biotech Customized adenovirus for overexpression of PTH1R Sirion Biotech Customized adenovirus for potent knockdown of PTH1R

Clone Products:		EMD Millipore Clones for the Expression of PTH1R
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTH1R (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTH1R (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PTH1R (NM_000316)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTH1R
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTH1R

Cell Line Products:		GenScript PTH1R-overexpressing Cell Line for Assay
		LifeMap BioReagents: cell lines associated with PTH1R: PureStem MEL2, NCr-fac Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
		Sirion Biotech Customized stable knockdown cell line services for PTH1R Sirion Biotech Customized inducible knockdown cell line services for PTH1R Sirion Biotech Customized stable overexpressing cell line services for PTH1R Sirion Biotech Customized inducible overexpressing cell line services for PTH1R

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTH1R

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

1.00

Development Hedgehog and PTH signaling pathways in bone and cartilage development

0.97

Class A/1 (Rhodopsin-like receptors)

GPCR ligand binding

0.75

Neuroactive ligand-receptor interaction

0.38

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for PTH1R

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Transcription Role of VDR in regulation of genes involved in osteoporosis

2 GeneGo (Thomson Reuters) Pathways for PTH1R

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Transcription Role of VDR in regulation of genes involved in osteoporosis

3 BioSystems Pathways for PTH1R

	Endochondral Ossification
	GPCRs, Class B Secretin-like
	Osteoblast Signaling

5/6 Reactome Pathways for PTH1R (see all 6)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

2 Kegg Pathways (Kegg details for PTH1R):

	Neuroactive ligand-receptor interaction
	Endocrine and other factor-regulated calcium reabsorption

PTH1R for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTH1R

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/72 Interacting proteins for PTH1R (Q03431^{2, 3} ENSP00000321999⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 72)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM2	P62158²^,³	MINT-51633 MINT-51634 I2D: score=1
CALM3	P62158²^,³	MINT-51633 MINT-51634 I2D: score=1
CALM1	P62158²^,³, ENSP00000349467⁴	MINT-51633 MINT-51634 I2D: score=1 STRING: ENSP00000349467
YWHAH	Q04917²^,³, ENSP00000248975⁴	MINT-15642 MINT-15641 MINT-5207093 I2D: score=2 STRING: ENSP00000248975
PTH	P01270³, ENSP00000282091⁴	I2D: score=2 STRING: ENSP00000282091

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	9745456
GO:0001503	ossification	--	--
GO:0002062	chondrocyte differentiation	IEA	--
GO:0002076	osteoblast development	IEA	--
GO:0006874	cellular calcium ion homeostasis	--	--

PTH1R for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTH1R for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PTH1R available from Tocris Bioscience About this table

Compound	Action	CAS #
Parathyroid hormone (1-34) (human)	Parathyroid hormone (PTH) receptor agonist	[52232-67-4]

1 HMDB Compound for PTH1R About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

2 DrugBank Compounds for PTH1R About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Preotact	hPTH (see all 10)	68893-82-3	target	activator	10837469
Teriparatide	hPTH 1-34 (see all 5)	52232-67-4	target	binder	11752352

10/33 Novoseek chemical compound relationships for PTH1R gene (see all 33) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	63.2	18	7664669 (2), 1664643 (2), 8275550 (1), 18450967 (1) (see all 16)
forskolin	61.7	5	9572838 (2), 8106573 (1), 12372804 (1), 7664644 (1)
calcium	60.6	43	7550580 (1), 11479139 (1), 16369896 (1), 7599930 (1) (see all 31)
cyclic amp	56	13	1718728 (3), 17264878 (2), 7550580 (1), 9011748 (1) (see all 7)
calcitriol	53	6	8807573 (2), 15728789 (1), 10912535 (1), 8229062 (1)
vitamin d	52.9	7	14562992 (1), 16261459 (1), 10620056 (1), 15157284 (1) (see all 6)
ribonucleic acid	44.7	3	7573236 (1), 7883858 (1), 8675577 (1)
benzophenone	42.6	3	7654710 (1), 10461746 (1)
bisindolylmaleimide	34.4	2	12210735 (1), 7664644 (1)
1,25 dihydroxy vitamin d3	33.5	1	15157284 (1)

Search CenterWatch for drugs/clinical trials and news about PTH1R

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTH1R gene (2 alternative transcripts):

NM_000316.2 NM_001184744.1

Unigene Cluster for PTH1R:

Parathyroid hormone 1 receptor

Hs.1019 [show with all ESTs]

Unigene Representative Sequence: U17418

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000449590(uc003cqm.3) ENST00000418619(uc021wxg.1) ENST00000427125

ENST00000313049 ENST00000428220 ENST00000490109 ENST00000422115 ENST00000430002

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTH1R
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate PTH1R:
		hsa-miR-125a-5p hsa-miR-125b hsa-miR-133a hsa-miR-133b hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: PTH1R 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTH1R (see all 4) OriGene shRNA RFP: PTH1R OriGene siRNA: PTH1R
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTH1R
		Sirion Biotech Custom design and validation of potent shRNA sequences against PTH1R

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTH1R (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTH1R (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PTH1R (NM_000316)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTH1R
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTH1R

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTH1R Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTH1R
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTH1R
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTH1R

Additional cDNA sequence:

AY449732.1 BC110388.1 BC112221.1 BC112247.1 L04308.1 U17418.1 X68596.1

8 DOTS entries:

DT.213440 DT.95079752 DT.100733251 DT.120876919 DT.95263621 DT.95126099 DT.100023926 DT.75101750

24/70 AceView cDNA sequences (see all 70):

BQ023127 CR595263 CA412652 BQ028831 BQ025985 BQ023754 BQ772345 BF526518

CA389051 AY449732 NM_000316 BX119179 BC031578 X68596 AA357377 BQ772116

BQ185264 U17418 AF495723 CA447251 BI755699 BM972131 BI765699 BG828526

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTH1R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACCAGGCG

About this image

PTH1R expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/43 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 43)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Selective marker (cell-identifying gene)

Bone

Caudal Endochondral Bones

Endochondral Preosteoblasts

Bone

Caudal Endochondral Bones

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Caudal Endochondral Bones

Prehypertrophic Chondrocytes

Bone, Cartilage

Bone

Endochondral Facial Bones

Endochondral Osteoblasts

Bone

Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Endochondral Facial Bones

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Endochondral Facial Bones

Prehypertrophic Chondrocytes

Bone, Cartilage

Bone

Membranous Facial Bones

Intramembranous Osteoblasts

Bone

Membranous Facial Bones

Intramembranous Preosteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/21 LifeMap Cells (see all 21)

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Connective tissue progenitor cells (Generation of connec...)

Extraembryonic endoderm-like cells (Generation of extrae...)

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)

Bone, Cartilage

See PTH1R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTH1R

SOURCE GeneReport for Unigene cluster: Hs.1019

UniProtKB/Swiss-Prot: PTH1R_HUMAN, Q03431

Tissue specificity: Expressed in most tissues. Most abundant in kidney, bone and liver

SABiosciences Expression via Pathway-Focused PCR Arrays including PTH1R:

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTH1R Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTH1R
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTH1R
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTH1R

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTH1R

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTH1R gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTH1R¹	parathyroid hormone 1 receptor	71.56(n) 77.32(a)		420401 NM_001177575.1 NP_001171046.1
lizard (Anolis carolinensis)	Reptilia	PTH1R⁶	--	72(a)	1 ↔ 1	GL343687.1(174417-213996)
zebrafish (Danio rerio)	Actinopterygii	pthr1²	parathyroid hormone receptor 1	77.18(n)		30629 AF132084.1
honey bee (Apis mellifera)	Insecta	-- -- (see all 4)	--	6(a) 29(a) (see all 4)	many ↔ many many ↔ many (see all 4)	Group9.2(517685-519657) GroupUn.2891(6917-15037)

ENSEMBL Gene Tree for PTH1R (if available)
TreeFam Gene Tree for PTH1R (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTH1R gene

GLP1R² GHRHR² GCGR² CALCR² CRHR2² VIPR1² CRHR1² PTH2R²

CALCRL² ADCYAP1R1² SCTR² GLP2R² VIPR2² GIPR²

14 SIMAP similar genes for PTH1R using alignment to 5 protein entries: PTH1R_HUMAN (see all proteins):

PTH2R PTHR2 GLP2R VIPR2 SCTR GCGR

VIPR1 GHRHR GLP1R GIPR CALCRL CRHR2

CALCR ADCYAP1R1

PTH1R for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121434601^1,2	C,F	probable-pathogenic	85552648(+)	`GTGACC/TGCAAT`	4	R C	mis¹		2		NA EU	5809
rs140330783^1,2		--	46917376(+)	`AAACAA/TGGCTG`	1	--	us2k¹		0	--	--	--	--
rs75124716^1,2	C	--	46917824(+)	`CAGGGC/TAACAG`	1	--	us2k¹		0	--	--	--	--
rs189467178^1,2		--	46917892(+)	`CCTCCA/GCTGGC`	1	--	us2k¹		0	--	--	--	--
rs151272497^1,2		--	46917918(+)	`CCTACA/GTGTCC`	1	--	us2k¹		0	--	--	--	--
rs115286342^1,2	F	--	46917952(+)	`ACTTCA/GGAGTA`	1	--	us2k¹		1		NA	120
rs140522020^1,2		--	46918171(+)	`CCCTAC/GGAATG`	1	--	us2k¹		0	--	--	--	--
rs150429247^1,2		--	46918267(+)	`GCCACA/GTGAAT`	1	--	us2k¹		0	--	--	--	--
rs114014705^1,2	F	--	46918799(+)	`CCAGCC/ACCCCT`	1	--	us2k¹		1		NA	120
rs181457831^1,2		--	46918940(+)	`AGAGGC/TATGGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTH1R (46919236 - 46945289 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PTH1R
1 CNV: 3428
Human Gene Mutation Database (HGMD): PTH1R

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTH1R

DNA2.0 Custom Variant and Variant Library Synthesis for PTH1R

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTH1R for disorders           About GeneDecksing

OMIM gene information: 168468
OMIM disorders: 156400  215045  600002  125350
UniProtKB/Swiss-Prot: PTH1R_HUMAN, Q03431

Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC) [MIM:156400]. JMC is a rare

autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low

serum concentrations of the two parathyroid hormones

Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD) [MIM:215045]. BOCD is a severe

skeletal dysplasia

Defects in PTH1R may be a cause of enchondromatosis multiple (ENCHOM) [MIM:166000]. Enchondromas are common

benign cartilage tumors of bone. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier

and Maffucci diseases). Clinical problems caused by enchondromas include skeletal deformity and the potential for

malignant change to osteosarcoma

Defects in PTH1R are the cause of Eiken skeletal dysplasia (EISD) [MIM:600002]; also known as bone modeling

defect of hands and feet. It is a rare familial autosomal recessive skeletal dysplasia. It is characterized by

multiple epiphyseal dysplasia, with extremely retarded ossification, principally of the epiphyses, pelvis, hands and

feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis

and mild growth retardation

Defects in PTH1R are a cause of primary failure of tooth eruption (PFE) [MIM:125350]. PFE is a rare condition

that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious

mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent

teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption

20/68 diseases for PTH1R (see all 68): About MalaCards

jansen's metaphyseal chondrodysplasia chondrodysplasia blomstrand type metaphyseal chondrodysplasia ossification of posterior longitudinal ligament of spine

chondrodysplasia pseudohypoparathyroidism type ib failure of tooth eruption, primary osteogenesis imperfecta

thanatophoric dysplasia oncogenic osteomalacia epiphyseal dysplasia pseudohypoparathyroidism

multiple epiphyseal dysplasia humoral hypercalcemia of malignancy ollier disease eiken syndrome

osteomalacia osteochondrodysplasia metaphyseal dysplasia achondroplasia

4 diseases from the University of Copenhagen DISEASES database for PTH1R:

Heart cancer Hypercalcemia Osteoporosis Metaphyseal dysplasia

10/35 Novoseek disease relationships for PTH1R gene (see all 35) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pseudohypoparathyroidism, type ib	84.3	8	8823526 (2), 7883858 (1), 8675577 (1), 9723884 (1) (see all 6)
hypercalcemia	78.2	13	8855805 (2), 9213256 (1), 8579896 (1), 7797535 (1) (see all 11)
pseudohypoparathyroidism	71.4	2	11857923 (2)
olliers disease	66.5	17	18559376 (5), 15523647 (4), 11850620 (2), 15525660 (1) (see all 5)
osteosarcoma	65.2	15	17410535 (3), 8020952 (2), 20156969 (1), 11250917 (1) (see all 10)
dwarfism	63.8	6	8579896 (1), 9832466 (1), 11297619 (1), 19061984 (1)
osteoporosis	54.8	8	18248821 (1), 15744035 (1), 11397646 (1), 11182376 (1) (see all 5)
skeletal dysplasia	51.3	4	16274647 (1), 15525660 (1), 8855805 (1), 9391087 (1)
osteochondrodysplasias	50.2	3	19061984 (1)
bone diseases	49.9	3	10633457 (1), 9263684 (1)

Human Genome Epidemiology (HuGE) Navigator: PTH1R (0 documents)

Export disorders for PTH1R gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PTH1R gene, integrated from 9 sources (see all 374):
(articles sorted by number of sources associating them with PTH1R)

Utopia: connect your pdf to the dynamic
world of online information

Enchondromatosis (Ollier disease, Maffucci syndrome) is not caused by the PTHR1 mutation p.R150C. (PubMed id 15523647)^{1, 2, 9} Rozeman L.B.... Bovee J.V.M.G. (2004)
Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes. (PubMed id 8020952)^{1, 3, 9} Pausova Z....Szpirer C. (1994)
PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. (PubMed id 19061984)^{1, 2, 9} Decker E....Weber B.H. (2008)
Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia. (PubMed id 9178745)^{1, 2, 9} Schipani E....Jueppner H. (1997)
The N-terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern. (PubMed id 10913300)^{1, 2, 9} Grauschopf U.... Rudolph R. (2000)
A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. (PubMed id 9745456)^{1, 2, 9} Zhang P.... Silve C. (1998)
A mutant PTH/PTHrP type I receptor in enchondromatosis. (PubMed id 11850620)^{1, 2, 9} Hopyan S.... Alman B.A. (2002)
Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. (PubMed id 8386612)^{1, 2, 9} Schipani E.... Jueppner H. (1993)
Structural basis for parathyroid hormone-related prot ein binding to the parathyroid hormone receptor and design of conformation-sele ctive peptides. (PubMed id 19674967)^{1, 2, 9} Pioszak A.A....Xu H.E. (2009)
Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. (PubMed id 8703170)^{1, 2, 9} Schipani E.... Jueppner H. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5745	HGNC: 9608	AceView: PTHR1	Ensembl:ENSG00000160801	euGenes: HUgn5745
ECgene: PTH1R	Kegg: 5745	H-InvDB: PTH1R

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PTH1R	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PTH1R

Intellectual Property for PTH1R gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PTH1R gene:
Search GeneIP for patents involving PTH1R

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Purified and/or Recombinant PTH1R Protein
	EMD Millipore Clones for the Expression of PTH1R
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for PTH1R (PTH1R/PTHR1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for PTH1R (PTH1R/PTHR1)

	Browse OriGene Antibodies		OriGene shRNA RFP for PTH1R
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTH1R		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTH1R
	OriGene Protein Over-expression Lysate for PTH1R		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PTH1R		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTH1R		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTH1R
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PTH1R		OriGene Custom Protein Services for PTH1R
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTH1R
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTH1R
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTH1R
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTH1R
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTH1R
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTH1R

	GenScript Custom Purified and Recombinant Proteins Services for PTH1R		GenScript cDNA clones with any tag delivered in your preferred vector for PTH1R
	GenScript PTH1R-overexpressing Cell Line for Assay		GenScript Custom Superior Antibodies Services for PTH1R
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PTH1R promoter
	Search Chromatin IP Primers for PTH1R
	RT² qPCR Primer Assay in human, mouse, rat PTH1R
	GNC Network for PTH1R
	SABiosciences PCR Arrays including human, mouse, rat PTH1R

Tocris compounds for PTH1R

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PTH1R antibodies
	PTH1R proteins
	PTH1R lysates

	Antibodies for PTH1R
	See all of Abcam's Antibodies, Kits and Proteins for PTH1R
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

PTH1R Proteins, Antibodies, CLIAs, and ELISAs

Cell Lines associated with PTH1R: PureStem MEL2, NCr-fac Progenitor,
PureStem SK11, NCr-fac & Meso-prx Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTH1R

	SwitchGear 3'UTR luciferase reporter plasmids for PTH1R
	SwitchGear Promoter luciferase reporter plasmids for PTH1R

ThermoFisher Antibody for PTH1R

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTH1R

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PTH1R

Sirion Biotech Customized:

	stable knockdown cell line services for PTH1R
	inducible knockdown cell line services for PTH1R
	design and validation of potent shRNA sequences against PTH1R
	adenovirus for potent knockdown of PTH1R
	adenovirus for overexpression of PTH1R
	stable overexpressing cell line services for PTH1R
	inducible overexpressing cell line services for PTH1R

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PTH1R gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

PTH1R Gene

parathyroid hormone 1 receptor

Aliases
for PTH1R gene

Summaries
for PTH1R gene

Genomic Views
for PTH1R gene

Proteins
for PTH1R gene

Protein Domains /
Families
for PTH1R gene

Function
for PTH1R gene

Pathways & Interactions
for PTH1R gene

Drugs & Compounds
for PTH1R gene

Transcripts
for PTH1R gene

Expression
for PTH1R gene

Orthologs
for PTH1R gene

Paralogs
for PTH1R gene

Genomic Variants
for PTH1R gene

Disorders / Diseases
for PTH1R gene

Publications
for PTH1R gene

External Searches for PTH1R gene

Genome Databases showing PTH1R gene

Other Databases showing PTH1R gene

Specialized Databases showing PTH1R gene

Intellectual Property
for PTH1R gene

Products
for PTH1R gene

View Random Gene

Olliers Disease
Chondrosarcoma
BREAST CARCINOMA
Glioma
Skeletal dysplasia
Carcinoma
PROSTATE CARCINOMA
Bone Diseases
Breast Cancer
Osteosarcoma
Dwarfism
Osteoporosis
Calcification
Thanatophoric Dysplasia
Pancreatic Cancer
PSEUDOHYPOPARATHYROIDISM, TYPE IB
bone loss
Hypercalcemia
Osteochondrodysplasias
HYPERPARATHYROIDISM PRIMARY
Hypoparathyroidism
Hypertrophy
Pseudohypoparathyroidism
Renal Failure
Osteogenesis Imperfecta
prostate cancer
Tumors
Metastasis
Cholera
Necrosis
genetic disorder
Osteomalacia
bone metastases
Achondroplasia
Renal Failure Chronic

Advanced Search

Export list of displayed genes

PTH1R Gene

parathyroid hormone 1 receptor

Aliasesfor PTH1R gene

Summariesfor PTH1R gene

Genomic Viewsfor PTH1R gene

Proteinsfor PTH1R gene

Protein Domains /Familiesfor PTH1R gene

Functionfor PTH1R gene

Pathways & Interactionsfor PTH1R gene

Drugs & Compoundsfor PTH1R gene

Transcriptsfor PTH1R gene

Expression for PTH1R gene

Orthologsfor PTH1R gene

Paralogsfor PTH1R gene

Genomic Variantsfor PTH1R gene

Disorders / Diseasesfor PTH1R gene

Publicationsfor PTH1R gene

External Searches for PTH1R gene

Genome Databases showing PTH1R gene

Other Databases showing PTH1R gene

Specialized Databases showing PTH1R gene

Intellectual Propertyfor PTH1R gene

Productsfor PTH1R gene

View Random Gene

Aliases
for PTH1R gene

Summaries
for PTH1R gene

Genomic Views
for PTH1R gene

Proteins
for PTH1R gene

Protein Domains /
Families
for PTH1R gene

Function
for PTH1R gene

Pathways & Interactions
for PTH1R gene

Drugs & Compounds
for PTH1R gene

Transcripts
for PTH1R gene

Expression
for PTH1R gene

Orthologs
for PTH1R gene

Paralogs
for PTH1R gene

Genomic Variants
for PTH1R gene

Disorders / Diseases
for PTH1R gene

Publications
for PTH1R gene

Intellectual Property
for PTH1R gene

Products
for PTH1R gene