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PTH Gene

protein-coding   GIFtS: 66
GCID: GC11M013470

Parathyroid Hormone

  See PTH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Parathyroid Hormone1 2     Preproparathyroid Hormone1 2
parathormone1 2     PTH12
parathyrin1 2     Parathormone3
Parathyroid Hormone 11 2     Parathyrin3
prepro-PTH1 2     

External Ids:    HGNC: 96061   Entrez Gene: 57412   Ensembl: ENSG000001522667   OMIM: 1684505   UniProtKB: P012703   

Export aliases for PTH gene to outside databases

Previous GC identifers: GC11M014784 GC11M014262 GC11M013552 GC11M013477 GC11M013193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTH Gene:
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+
level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of
familial isolated hypoparathyroidism (FIH). (provided by RefSeq, Jul 2008)

GeneCards Summary for PTH Gene:
PTH (parathyroid hormone) is a protein-coding gene. Diseases associated with PTH include uremic neuropathy, and hypervitaminosis d. GO annotations related to this gene include hormone activity and peptide hormone receptor binding.

UniProtKB/Swiss-Prot: PTHY_HUMAN, P01270
Function: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells

Gene Wiki entry for PTH (Parathyroid hormone) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTH gene promoter:
         TBP   AP-1   Pax-6   ATF-2   Tal-1beta   C/EBPalpha   E47   TFIID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTH promoter sequence
   Search Chromatin IP Primers for PTH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3-p15.1   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.3-p15.1

PTH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTH gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M013470:  view genomic region     (about GC identifiers)

Start:
13,513,601 bp from pter      End:
13,517,728 bp from pter
Size:
4,128 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PTHY_HUMAN, P01270 (See protein sequence)
Recommended Name: Parathyroid hormone precursor  
Size: 115 amino acids; 12861 Da
Subunit: Interacts with PTH1R (via N-terminal extracellular domain)
Selected PDB 3D structures from and Proteopedia for PTH (see all 15):
1BWX (3D)        1ET1 (3D)        1ET2 (3D)        1FVY (3D)        1HPH (3D)        1HPY (3D)    
Secondary accessions: Q4VB48 Q9UD38

Explore the universe of human proteins at neXtProt for PTH: NX_P01270

Explore proteomics data for PTH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PTH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000306.1  
    ENSEMBL proteins: 
     ENSP00000282091   ENSP00000433208  
    Reactome Protein details: P01270

    PTH Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR003625 PTH
     IPR001415 PTH/PTH-rel

    Graphical View of Domain Structure for InterPro Entry P01270

    ProtoNet protein and cluster: P01270

    1 Blocks protein domain: IPB001415 Parathyroid hormone

    UniProtKB/Swiss-Prot: PTHY_HUMAN, P01270
    Similarity: Belongs to the parathyroid hormone family


    Find genes that share domains with PTH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTHY_HUMAN, P01270
    Function: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
    Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells

         Genatlas biochemistry entry for PTH:
    parathyroid hormone,9.5kDa,formed from a 12.5kDa precursor

         Summary: 
    During embryonic development, PTH as signaling molecule is secreted from the following cells:
                
    Thyroid: Chief Cells of Parathyroid (Parathyroid)

    It affects the following cells:       fully expand
    Bone: Immature Endochondral Osteoblasts (Rostral Endochondral Facial Bones), Endochondral Preosteoblasts (Endochondral Facial Bones)      fully expand to see all 16 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IMP17696759
    GO:0005179hormone activity IEA--
    GO:0031856parathyroid hormone receptor binding ----
    GO:0031857type 1 parathyroid hormone receptor binding IEA--
    GO:0051428peptide hormone receptor binding IDA19674967
         
    Find genes that share ontologies with PTH           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pth):
     cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  skeleton 

    Find genes that share phenotypes with PTH           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pthtm1Dgo for PTH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTH

    miRNA
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    miRTarBase miRNAs that target PTH:
    hsa-mir-335-5p (MIRT018218)

    Block miRNA regulation of human, mouse, rat PTH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTH (see all 11):
    hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-646 hsa-miR-103a hsa-miR-424 hsa-miR-186 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidPTH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PTH

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PTH (NM_000315)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PTHY_HUMAN, P01270: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    plasma membrane3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with PTH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTH About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    GPCR ligand binding0.71
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    4Vitamin D synthesis
    Vitamin D synthesis
    5Transcription Role of VDR in regulation of genes involved in osteoporosis
    Transcription Role of VDR in regulation of genes involved in osteoporosis


    Find genes that share SuperPaths with PTH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for PTH
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    3 BioSystems Pathways for PTH
        Vitamin D synthesis
    Endochondral Ossification
    Osteoblast Signaling


    2 Reactome Pathways for PTH
        G alpha (s) signalling events
    Class B/2 (Secretin family receptors)


        Pathway & Disease-focused RT2 Profiler PCR Array including PTH: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTH (P012702, 3 ENSP000002820914) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-63346 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63346 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63346 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63346 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63346 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17696759
    GO:0001501skeletal system development TAS10913913
    GO:0006366transcription from RNA polymerase II promoter IMP17696759
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS7797535

    Find genes that share ontologies with PTH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTH (PTHY)

    1 HMDB Compound for PTH    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for PTH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Norleucine-- --target----

    Selected Novoseek inferred chemical compound relationships for PTH gene (see all 51)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    25-hydroxyvitamin d 76.4 26 9435366 (2), 10672132 (1), 11388078 (1), 16807549 (1) (see all 22)
    vitamin d 74.5 56 8891962 (4), 17854393 (3), 11705321 (3), 17368185 (3) (see all 36)
    calcitriol 72.5 31 10988200 (3), 12213894 (3), 10720039 (2), 9730564 (1) (see all 23)
    calcium 71.4 337 9768650 (7), 7705374 (5), 1291861 (5), 20032048 (5) (see all 99)
    deoxypyridinoline 66.3 15 18004084 (2), 14555415 (1), 19158198 (1), 18999899 (1) (see all 11)
    1,25 dihydroxy vitamin d3 65.7 10 9626120 (2), 10077002 (1), 12788900 (1), 17293108 (1) (see all 9)
    doxercalciferol 55 3 16282676 (3)
    phosphorus 54.7 46 8647946 (8), 15486872 (3), 19463763 (3), 16160737 (2) (see all 17)
    procollagen 50.5 13 16352693 (2), 12788900 (1), 12381951 (1), 15049968 (1) (see all 7)
    forskolin 48.4 16 12209875 (4), 2175562 (1), 18450967 (1), 9572838 (1) (see all 8)



    Find genes that share compounds with PTH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTH gene: 
    NM_000315.2  

    Unigene Cluster for PTH:

    Parathyroid hormone
    Hs.37045  [show with all ESTs]
    Unigene Representative Sequence: NM_000315
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282091(uc001mlb.3) ENST00000529816
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTH (see all 11):
    hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-646 hsa-miR-103a hsa-miR-424 hsa-miR-186 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidPTH 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat PTH

    Additional mRNA sequence: 

    BC096142.1 BC096143.1 BC096144.3 BC096145.1 V00597.1 

    1 DOTS entry:

    DT.318355 

    Selected AceView cDNA sequences (see all 100):

    AI092021 AA037414 N89821 AA888818 AI050896 N90261 NM_000315 W39202 
    W56886 W37708 W37306 AI457923 BX106232 AI028087 AI077978 AI050910 
    W16850 W32642 W31998 BX103059 N92513 N91351 AA372113 W38966 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTAATTC
    PTH Expression
    About this image


    PTH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Thyroid (Endocrine System)
    PTH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37045
        Pathway & Disease-focused RT2 Profiler PCR Array including PTH: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTH gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pth1 , 5 parathyroid hormone1, 5 78.55(n)1
    67.83(a)1
      7 (59.19 cM)5
    192261  NM_020623.21  NP_065648.11 
     1133855765 
    chicken
    (Gallus gallus)
    Aves PTH1 parathyroid hormone 67.3(n)
    55.24(a)
      396436  NM_205452.2  NP_990783.1 


    ENSEMBL Gene Tree for PTH (if available)
    TreeFam Gene Tree for PTH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTH (see all 134)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0060474
    Hypoparathyroidism, familial isolated (FIH)4--see VAR_0060472 C R mis40--------
    VAR_0184644
    Hypoparathyroidism, familial isolated (FIH)4--see VAR_0184642 S P mis40--------
    rs62561,2
    C,F,A,Hpathogenic113438416(-) GGCCCA/C/TGAAAA 2 R * stg1 ese323MN NA NS EA WA EU 7824
    rs1048942721,2
    Cpathogenic113438699(-) CAAAAC/TCGGAT 2 P S mis10--------
    rs1048942711,2
    Cpathogenic113438714(-) CAATTC/TGTTTT 2 R C mis10--------
    rs783366271,2
    C,F--13437498(+) TAGGCC/TGCATG 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs583151981,2
    C,F--13437503(+) CGCATG/ATAGAC 1 -- ds50012Minor allele frequency- A:0.19WA 120
    rs583991361,2
    C,F--13437562(+) GTACAC/TGACAA 1 -- ds50012Minor allele frequency- T:0.19WA 120
    rs728585191,2
    C,F--13437567(+) CGACAA/GACAAT 1 -- ds50012Minor allele frequency- G:0.23NA EA 240
    rs747037171,2
    C,F--13437596(+) TGTCAA/GATGAC 1 -- ds50011Minor allele frequency- G:0.05EA 120

    HapMap Linkage Disequilibrium report for PTH (13513601 - 13517728 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PTH: --
    Human Gene Mutation Database (HGMD): PTH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTH
    DNA2.0 Custom Variant and Variant Library Synthesis for PTH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 168450   
    OMIM disorders: 146200  
    UniProtKB/Swiss-Prot: PTHY_HUMAN, P01270
  • Hypoparathyroidism, familial isolated (FIH) [MIM:146200]: A disorder characterized by hypocalcemia and
    hyperphosphatemia due to inadequate secretion of parathyroid hormone. Clinical features include seizures, tetany
    and cramps. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for PTH (see all 30):    
    About MalaCards
    uremic neuropathy    hypervitaminosis d    pseudoarthrosis    hypoparathyroidism, autosomal dominant
    hypoparathyroidism    pth-related familial isolated hypoparathyroidism    hypoparathyroidism, autosomal recessive    clear cell adenoma
    renal osteodystrophy    uremia    osteitis fibrosa    spondylosis
    hypoparathyroidism familial isolated    parathyroid carcinoma    jansen's metaphyseal chondrodysplasia    parathyroid adenoma
    ossification of the posterior longitudinal ligament of the spine    primary hyperparathyroidism    familial isolated hyperparathyroidism    hyperphosphatemia

    Selected diseases from the University of Copenhagen DISEASES database for PTH (see all 30):
    Hyperparathyroidism     Hypercalcemia     Parathyroid adenoma     Osteoporosis
    Hypoparathyroidism     Kidney failure     Hyperphosphatemia     Pseudohypoparathyroidism
    Renal osteodystrophy     Osteomalacia     Osteitis fibrosa     Hypophosphatemia
    Parathyroid carcinoma     Adenoma     Calcinosis     Rickets
    Nephrolithiasis     X-linked hypophosphatemia     Metabolic acidosis     Hypertension

    Find genes that share disorders with PTH           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTH gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperparathyroidism secondary 81.4 23 17854393 (2), 12940896 (2), 12753275 (2), 15332221 (2) (see all 13)
    hypercalcemia 80.8 58 1849762 (4), 16077176 (4), 1993319 (3), 10660809 (3) (see all 35)
    hyperparathyroidism primary 80.5 31 16491288 (3), 1689222 (2), 8369362 (2), 10468923 (2) (see all 20)
    parathyroid adenoma 79.5 17 2199477 (2), 10704427 (2), 8626826 (1), 15775480 (1) (see all 11)
    hyperparathyroidism 74.5 16 16263810 (1), 9730564 (1), 1643722 (1), 7903311 (1) (see all 13)
    hypoparathyroidism 69.6 14 9768650 (3), 1993319 (2), 7752497 (1), 17721071 (1) (see all 7)
    pseudohypoparathyroidism, type ib 69.6 1 10971097 (1)
    hyperphosphatemia 69 6 17178702 (2), 10620210 (1), 12940896 (1), 12753275 (1) (see all 5)
    renal osteodystrophy 69 3 10077343 (2), 8258962 (1)
    bone diseases 61.8 8 8671970 (4), 10620210 (1), 18587716 (1), 11277262 (1) (see all 5)

    Genatlas disease: PTH
    hypoparathyroidism,familial,isolated,dominant and recessive types

    Genetic Association Database (GAD): PTH
    Human Genome Epidemiology (HuGE) Navigator: PTH (112 documents)
    Tumor Gene Database (TGDB): PTH

    Export disorders for PTH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTH gene, integrated from 10 sources (see all 568):
    (articles sorted by number of sources associating them with PTH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [Polymorphism of parathyroid hormone gene and its association with bone mineral density of Han nationality women in Beijing area]. (PubMed id 12905817)1, 4, 9 Li M....Xing X.P. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001)
    2. Associations of vitamin D receptor, calcium-sensing receptor and parathyroid hormone gene polymorphisms with calcium homeostasis and peripheral bone density in adult Finns. (PubMed id 19690432)1, 4, 9 Laaksonen M.M....Lamberg-Allardt C.J. (J Nutrigenet Nutrigenomics 2009)
    3. Regional mapping of the parathyroid hormone gene (PTH) by cytogenetic and molecular studies. (PubMed id 1672845)1, 3, 9 Tonoki H....Niikawa N. (Cytogenet. Cell Genet. 1991)
    4. Variation in the PTH gene, hip fracture, and femoral neck geometry in elderly women. (PubMed id 20349051)1, 4 Tenne M....Akesson K. (Calcif. Tissue Int. 2010)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. (PubMed id 19874204)1, 4 Guo Y....Deng H.W. (J. Bone Miner. Res. 2010)
    8. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    9. Parathyroid hormone gene variant and calcific aortic stenosis. (PubMed id 19557980)1, 4 Schmitz F....Ortlepp J.R. (J. Heart Valve Dis. 2009)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5741 HGNC: 9606 AceView: PTH Ensembl:ENSG00000152266 euGenes: HUgn5741
    ECgene: PTH H-InvDB: PTH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTH Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Parathyroid_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTH gene:
    Search GeneIP for patents involving PTH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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