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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTGS2 Gene

protein-coding GIFtS: 71
GCID: GC01M186640

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H...

Explore 359 diseases affiliated with
PTGS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase And Cyclooxygenase)¹ ²		PGG/HS²
COX2¹ ² ³		PHS-2²
Prostaglandin H2 Synthase 2² ³		Cyclooxygenase 2b²
COX-2² ³		HCox-2¹
PGHS-2² ³		Prostaglandin G/H Synthase 2²
PGH Synthase 2² ³		Cyclooxygenase-2³
PHS II² ³		Prostaglandin-Endoperoxide Synthase 2³
EC 1.14.99.1³ ⁸		EC 1.14.99⁸
GRIPGHS²

External Ids:	HGNC: 9605¹	Entrez Gene: 5743²	Ensembl: ENSG00000073756⁷	OMIM: 600262⁵	UniProtKB: P35354³

Export aliases for PTGS2 gene to outside databases

Previous GC identifers: GC01M184166 GC01M182068 GC01M183160 GC01M183879 GC01M183372 GC01M184907 GC01M157875

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGS2:

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin

biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1

and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the

inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the

prostanoid biosynthesis involved in inflammation and mitogenesis. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354

Function: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of

inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

summary for PTGS2:

Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is

expressed in cells in three isoforms: COX-1, COX-2 and COX-3. COX-1 (constitutive) and COX-2 (inducible)

isoforms catalyze the rate-limiting step of prostaglandin production and are the targets of non-steroidal

anti-inflammatory drugs. COX-3 does not appear to be involved in inflammatory processes, but seems to be

involved in pain and fever. COX-3 is thought to be derived through the retention of the highly structured G

+ C-rich intron 1 of the COX-1 gene.

Gene Wiki entry for PTGS2

PharmGKB "VIP" summary for PTGS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTGS2 gene promoter:
AP-1 ATF-2 POU6F1 (c2) STAT5A CREB deltaCREB FOXJ2 (long isoform) c-Jun FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTGS2 promoter sequence

Search SABiosciences Chromatin IP Primers for PTGS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2-q25.3 Ensembl cytogenetic band: 1q31.1 HGNC cytogenetic band: 1q25.2-q25.3

PTGS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGS2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M186640: view genomic region (about GC identifiers)

Start:	186,640,923 bp from pter	End:	186,649,559 bp from pter
Size:	8,637 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354 (See protein sequence)

Recommended Name: Prostaglandin G/H synthase 2 precursor

Size: 604 amino acids; 68996 Da

Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)

Subunit: Homodimer (By similarity)

Subcellular location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral

membrane protein

Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase

Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin

1 PDB 3D structure from and Proteopedia for PTGS2:

1V0X (3D)

Secondary accessions: A8K802 Q16876

Explore the universe of human proteins at neXtProt for PTGS2: NX_P35354

Post-translational modifications:

S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in

addition to Cys-561¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35354

4/30 DME Specific Peptides for PTGS2 (P35354) (see all 30)

LYHWHPL

ASIDQSR

IINTASI

LGHGVDL

PTGS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000954.1

ENSEMBL proteins:

ENSP00000356438 ENSP00000454130

Reactome Protein details: P35354
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PTGS2 OriGene Custom Protein Services for PTGS2
	GenScript Custom Purified and Recombinant Proteins Services for PTGS2
	Novus Biologicals PTGS2 Proteins Novus Biologicals PTGS2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTGS2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	--	--

PTGS2 for ontologies About GeneDecksing

PTGS2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGS2
	R&D Systems Antibodies for PTGS2 (COX-2)
	Cell Signaling Technology (CST) Antibodies for PTGS2 (COX-2)
	OriGene Antibodies (see all 3): PTGS2 OriGene Custom Antibody Services for PTGS2
	GenScript Custom Superior Antibodies Services for PTGS2
	Novus Biologicals PTGS2 Antibodies
	Abcam antibodies for PTGS2
	Uscn Antibodies for PTGS2
	ThermoFisher Antibodies for PTGS2

Assay Products for PTGS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for PTGS2 (COX-2) (see all)
	GenScript Custom Assay Services for PTGS2
	Cell Signaling Technology (CST) Sandwich ELISA Kits for PTGS2 (COX-2)
	Enzo Life Sciences assays for PTGS2
	Uscn ELISAs and CLIAs for PTGS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTGS2 for domains About GeneDecksing

4 InterPro domains/families:

IPR000742 EG-like_dom

IPR010255 Haem_peroxidase

IPR019791 Haem_peroxidase_animal_subgr

IPR002007 Haem_peroxidase_animal

Graphical View of Domain Structure for InterPro Entry P35354

ProtoNet protein and cluster: P35354

3 Blocks protein families:

IPB002007 Animal haem peroxidase signature

IPB006210 Type I EGF

IPB010255 Haem peroxidase

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354

Similarity: Belongs to the prostaglandin G/H synthase family

Similarity: Contains 1 EGF-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354

Function: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of

inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O

Biophysicochemical properties: Kinetic parameters: KM=16.2 uM for arachidonate (in absence of sodium nitroprusside NO

donor); KM=17.0 uM for arachidonate (in presence of sodium nitroprusside NO donor); Vmax=81.3 nmol/min/mg enzyme (in

absence of sodium nitroprusside NO donor); Vmax=132 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor);

Induction: By cytokines and mitogens

Genatlas biochemistry entry for PTGS2:

prostaglandin G/H synthase 2,mitogen and cytokine inducible form (lipocalin family,Kernel group),monomer,potent

mediator of inflammation,playing a minor role in colorectal carcinogenesis,overexpressed in squamous cell carcinoma of

the head and neck,putatively involved in the tumor tissue response to necrosis

Enzyme Numbers (IUBMB): EC 1.14.99.1¹ ² EC 1.14.99²

miRNA Products:		miRTarBase miRNAs that target PTGS2: hsa-mir-101 (MIRT004297), hsa-let-7b (MIRT001603), hsa-mir-16 (MIRT001426), hsa-mir-26b (MIRT004659)

		OriGene 3'-UTR Clone: PTGS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGS2
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGS2 (see all 23):
		hsa-miR-4291 hsa-miR-576-3p hsa-miR-624* hsa-miR-1297 hsa-miR-144 hsa-miR-629* hsa-miR-558 hsa-miR-1827

		SwitchGear 3'UTR luciferase reporter plasmid: PTGS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGS2 (see all 7) OriGene shRNA RFP: PTGS2 OriGene siRNA: PTGS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PTGS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTGS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTGS2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTGS2 (NM_000963)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTGS2
		Search LifeMap BioReagents cell lines for PTGS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004601	peroxidase activity	NAS	14511332
GO:0004666	prostaglandin-endoperoxide synthase activity	IDA	1380156
GO:0005515	protein binding	--	--
GO:0008289	lipid binding	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--

PTGS2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for PTGS2: Ptgs2^tm1Unc Ptgs2^{tm2(Ptgs1)Fun} Ptgs2^tm3Fun Ptgs2^tm1Jed
     15/25 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Ptgs2) (see all 25):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle

PTGS2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/39 super-pathways (see all 39) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Arachidonic acid metabolism

Arachidonic acid metabolism	1.00	HETE and HPETE biosynthesis and metabolism	0.39
Arachidonic acid metabolism	0.42	Eicosanoid Synthesis	0.31
HETE and HPETE biosynthesis and metabolism	0.39

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	1.00			Prostaglandin 2 biosynthesis and metabolism FM	0.44
	prostanoid biosynthesis	0.50			Prostaglandin 2 biosynthesis and metabolism FM	0.44

PEDF Induced Signaling

	MIF Mediated Glucocorticoid Regulation	0.73			all-trans-Retinoic Acid Signaling in Brain	0.59
	MIF Regulation of Innate Immune Cells	0.71			Endothelin-1 Signaling Pathway	0.44

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for PTGS2 (see all 9)

	Development HGF signaling pathway
	Prostaglandin 2 biosynthesis and metabolism FM
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	HETE and HPETE biosynthesis and metabolism

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTGS2 (see all 13)

	MIF Regulation of Innate Immune Cells
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	HGF Pathway
	Endothelin-1 Signaling Pathway
	Colorectal Cancer Metastasis

3 Cell Signaling Technology (CST) Pathways for PTGS2

	Angiogenesis
	Neuroscience
	NF-kappaB Signaling

5/10 GeneGo (Thomson Reuters) Pathways for PTGS2 (see all 10)

	HETE and HPETE biosynthesis and metabolism
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	Development VEGF signaling via VEGFR2 - generic cascades
	Transcription PPAR Pathway

5/11 BioSystems Pathways for PTGS2 (see all 11)

	Eicosanoid Synthesis
	Integrated Pancreatic Cancer Pathway
	Prostaglandin Synthesis and Regulation
	Integrated Pancreatic Cancer Pathway
	Selenium Pathway

5 Reactome Pathways for PTGS2

	Metabolism
	Arachidonic acid metabolism
	Synthesis of 15-eicosatetraenoic acid derivatives
	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
	Metabolism of lipids and lipoproteins

4 PharmGKB Pathways for PTGS2

	Acetaminophen Pathway, Pharmacokinetics
	Celecoxib Pathway, Pharmacodynamics
	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
	Pathway_PA165986194 -need delete

5/6 Kegg Pathways (Kegg details for PTGS2) (see all 6):

	Arachidonic acid metabolism
	Metabolic pathways
	VEGF signaling pathway
	Leishmaniasis
	Pathways in cancer

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354

Pathway: Lipid metabolism; prostaglandin biosynthesis

PTGS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTGS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/79 Interacting proteins for PTGS2 (P35354³ ENSP00000356438⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637³, ENSP00000269305⁴	I2D: score=3 STRING: ENSP00000269305
CAV1	Q03135³, ENSP00000339191⁴	I2D: score=2 STRING: ENSP00000339191
COPS3	Q9UNS2³, ENSP00000268717⁴	I2D: score=2 STRING: ENSP00000268717
COPS5	Q92905³, ENSP00000350512⁴	I2D: score=2 STRING: ENSP00000350512
CUL1	Q13616³, ENSP00000326804⁴	I2D: score=2 STRING: ENSP00000326804

About this table

Gene Ontology (GO): 5/63 biological process terms (GO ID links to tree view) (see all 63): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001516	prostaglandin biosynthetic process	NAS	--
GO:0001525	angiogenesis	IEA	--
GO:0006692	prostanoid metabolic process	--	--
GO:0006693	prostaglandin metabolic process	TAS	9630216
GO:0006805	xenobiotic metabolic process	TAS	--

PTGS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTGS2 for compounds About GeneDecksing

EMD Millipore small molecules for PTGS2:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for PTGS2

Compounds for PTGS2 available from Tocris Bioscience About this table

Compound	Action	CAS #
DuP 697	Cyclooxygenase-2 (COX-2) inhibitor	[88149-94-4]
Nimesulide	Cyclooxygenase-2 (COX-2) inhibitor	[51803-78-2]
Celecoxib	Selective cyclooxygenase-2 (COX-2) inhibitor	[169590-42-5]
NS 398	Cyclooxygenase-2 (COX-2) inhibitor	[123653-11-2]
Valdecoxib	Selective and potent COX-2 inhibitor	[181695-72-7]

10/16 HMDB Compounds for PTGS2 (see all 16) About this table

Compound	Synonyms	CAS #	PubMed Ids
11R-HEPE	11(R)-hydroxyeicosa-5Z,8Z,12E,14Z,17Z-pentaenoate (see all 2)	--	--
Acetaminophen	4'-Hydroxyacetanilide (see all 629)	103-90-2	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Aspirin	2-(Acetyloxy)benzoic acid (see all 59)	50-78-2	--
Celecoxib	Celebrex (see all 3)	169590-42-5	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Ibuprofen	alpha-(4-Isobutylphenyl)propionate (see all 9)	15687-27-1	--
Iron	Armco iron (see all 19)	7439-89-6	--
Naproxen	(+)-(S)-Naproxen (see all 49)	22204-53-1	--
Oxygen	Oxygen (see all 5)	7782-44-7	--

10/67 DrugBank Compounds for PTGS2 (see all 67) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Rofecoxib	MK 966 (see all 2)	162011-90-7	target	inhibitor	10566562 20724158 10555907 10693877 11752352 18922570 20166930 11398914 10643177 10580458
Flurbiprofen	FLP (see all 5)	5104-49-4	target	inhibitor	19066416 17562170 10091674 10773011 10977131 11006278 11405284
Valdecoxib	--	181695-72-7	target	inhibitor	11060833 12564662 12167567 10715145 11752352 12644588 15494548
Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid (see all 24)	50-78-2	target	inhibitor	17033106 17301265 17258197 11752352 17037745 17181859
Antrafenine	--	55300-30-6	target	inhibitor	17604186 17612049 17607546 11752352 17532719 17521299
Bismuth Subsalicylate	Bismuth (see all 6)	14882-18-9	target	inhibitor	5284360 15070163 15106733 15348270 15035793 15199473
Carprofen	2-(6-Chloro-9H-carbazol-2-yl)propanoic acid (see all 6)	53716-49-7	target	inhibitor	15198222 11703020 10895904 17181139 15939622 11752352
Celecoxib	--	169590-42-5	target	inhibitor	12055598 12093311 12104042 11752352 12086402 12086292
Diflunisal	--	22494-42-4	target	inhibitor	8737748 11673972 10825891 11752352 11315375 12852483
Etodolac	--	41340-25-4	target	inhibitor	15198222 11009046 11752352 12824918 10594327 11275997

10/117 Novoseek chemical compound relationships for PTGS2 gene (see all 117) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
celecoxib	97	1888	18230053 (7), 18766003 (7), 15014359 (6), 16230415 (6) (see all 99)
rofecoxib	96	933	20110006 (10), 10411562 (6), 17620346 (5), 17636557 (4) (see all 99)
pge2	94.8	3923	18727513 (9), 19452719 (9), 12493746 (8), 16585602 (7) (see all 99)
prostaglandin	92.7	1317	10735591 (5), 10692251 (4), 9016346 (4), 8063757 (3) (see all 99)
ns 398	92.2	312	14630280 (5), 15703831 (4), 15382039 (4), 19956533 (4) (see all 99)
valdecoxib	91.6	196	15494548 (6), 17605893 (3), 18171312 (3), 17429597 (3) (see all 99)
etoricoxib	89.3	163	11160644 (5), 12817520 (4), 15827069 (3), 19392653 (3) (see all 99)
arachidonic acid	88.4	747	9373167 (6), 9461572 (5), 9973312 (4), 9031736 (4) (see all 99)
nimesulide	88.3	372	18333314 (5), 18288985 (5), 19152549 (4), 14977856 (4) (see all 99)
meloxicam	87.8	275	16245223 (4), 12911075 (3), 19078323 (3), 10812057 (3) (see all 99)

3 PharmGKB related drug/compound annotations for PTGS2 gene

Drug/compound	PharmGKB Annotation
aspirin	CA
ibuprofen	CA
rofecoxib	CA

About this table

Search CenterWatch for drugs/clinical trials and news about PTGS2 / PGH2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTGS2 gene:

NM_000963.2

Unigene Cluster for PTGS2:

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Hs.196384 [show with all ESTs]

Unigene Representative Sequence: NM_000963

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367468(uc001gsb.3 uc009wyo.3) ENST00000490885 ENST00000559627

ENST00000466691 ENST00000559800

miRNA Products:		OriGene 3'-UTR Clone: PTGS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGS2
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGS2 (see all 23):
		hsa-miR-4291 hsa-miR-576-3p hsa-miR-624* hsa-miR-1297 hsa-miR-144 hsa-miR-629* hsa-miR-558 hsa-miR-1827

		SwitchGear 3'UTR luciferase reporter plasmid: PTGS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGS2 (see all 7) OriGene shRNA RFP: PTGS2 OriGene siRNA: PTGS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGS2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTGS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTGS2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTGS2 (NM_000963)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTGS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTGS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGS2

Additional cDNA sequence:

AJ634912.1 AK292167.1 AY151286.1 AY462100.1 BC013734.1 HM473188.1 L15326.1 M90100.1

3 DOTS entries:

DT.413375 DT.91935010 DT.121406567

24/101 AceView cDNA sequences (see all 101):

AL710813 AJ634912 CK823042 BP335244 BG152882 BQ722004 AY462100 BM978796

CB143773 CK823043 D58162 BG236304 BQ100700 AA296431 BC013734 CB960307

BQ100978 CD365731 AA644211 BP337788 BX363285 BI335813 CA436148 CA445948

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PTGS2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b
SP1:																											-
SP2:																	-										-
SP3:																											-
SP4:
SP5:

ECgene alternative splicing isoforms for PTGS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTGS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTTCCTTT

About this image

PTGS2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Antral Follicle

Mural Granulosa Cells

Ovary

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

See PTGS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTGS2

SOURCE GeneReport for Unigene cluster: Hs.196384

SABiosciences Expression via Pathway-Focused PCR Arrays including PTGS2 (see all 25):

Lung Cancer in human mouse rat

Wound Healing in human mouse rat

Inflammasomes in human mouse rat

Prostate Cancer in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTGS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTGS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PTGS2 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTGS2¹	prostaglandin-endoperoxide synthase 2 (prostaglandin more	77.61(n) 81.76(a)		396451 NM_001167719.1 NP_001161191.1
lizard (Anolis carolinensis)	Reptilia	PTGS2⁶	--	78(a)	1 ↔ 1	GL343203.1(2256804-2267500)
African clawed frog (Xenopus laevis)	Amphibia	Xl.33329²	Xenopus laevis transcribed sequence with moderate similarity more	75.65(n)		CA988090.1
zebrafish (Danio rerio)	Actinopterygii	ptgs2²	prostaglandin-endoperoxide synthase 2	75.55(n)		246227 AY028585.1

ENSEMBL Gene Tree for PTGS2 (if available)
TreeFam Gene Tree for PTGS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTGS2 gene

PTGS1²

2 SIMAP similar genes for PTGS2 using alignment to 3 protein entries: PGH2_HUMAN (see all proteins):

COX-2 PTGS1

PTGS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4648310^1,2	C,F,H,	--	157875293(-)	`cctctA/Gtcctt`	1	--	ds500¹		22		NS EA NA	2134
rs4648309^1,2	C,F,	--	157875382(-)	`GGGGGC/GACAAA`	1	--	ds500¹		1		NS	180
rs4648307^1,2	C,F,A,H	--	157875471(-)	`GATGGA/AA /C/GCAAACA`	1	--	ds500¹		21		NS EA NA WA	2180
rs4648305^1,2	C,F,	--	157875590(-)	`ATGAAA/-TGGTT`	1	--	ds500¹		1		NS	180
rs4648304^1,2	C,F,H,	--	157875621(-)	`CCTACC/TTATTC`	1	--	ds500¹		14		NS EA NA WA	1514
rs191788711^1,2	C,	--	157875925(+)	`TACAAG/TCATAT`	1	--	ut3¹		0	--	--	--	--
rs4648303^1,2	C,F,H,	--	157875966(-)	`TTTTAC/TGTTTA`	1	--	ut3¹ ese³		10		NS EA NA	1344
rs689467^1,2	C,F,	--	157876041(-)	`AAAATT/GTTCTT`	1	--	ut3¹		5		NS NA	388
rs183201650^1,2	C,	--	157876086(+)	`TCAGCA/GTTTGA`	1	--	ut3¹		0	--	--	--	--
rs4648301^1,2	C,F,H,	--	157876126(-)	`ATATTC/TTGTGT`	1	--	ut3¹		14		NS EA NA WA	1822
rs188254107^1,2	C,	--	157876164(+)	`TTAACA/C/GAAGCA`	2	--	ut3¹		0	--	--	--	--
rs4648300^1,2	C,F,H,	--	157876179(-)	`TGAGGG/AATCTG`	1	--	ut3¹ ese³		7		NS EA WA	688
rs4648299^1,2	C,	--	157876345(-)	`GAAATG/TATTGT`	1	--	ut3¹		3		NS NA	180
rs11567830^1,2	C,F,H	--	157876377(-)	`TACCTC/ATCTGA`	1	--	ut3¹ ese³		12		NS EA NA	1406
rs13306035^1,2	C	--	157876615(-)	`TCTTAC/TTTAAA`	1	--	ut3¹		0	--	--	--	--
rs183653397^1,2	C	--	157876657(+)	`TTTCCA/GGTCAC`	1	--	ut3¹		0	--	--	--	--
rs13306033^1,2	C,	--	157876670(-)	`CTGTAC/TGGGGT`	1	--	ut3¹ ese³		0	--	--	--	--
rs13306032^1,2	C,H,	--	157876748(-)	`GCAGAG/TAATTT`	1	--	ut3¹ ese³		6		NS EA NA	422
rs4648297^1,2	C,	--	157876827(-)	`ATTTAG/ACTCCT`	1	--	ut3¹		1		NS	176
rs4648296^1,2	C,	--	157876836(-)	`AGGACT/CGCTAT`	1	--	ut3¹ ese³		3		NS NA	180
rs11567829^1,2	C,H,	--	157876918(-)	`TAAGAT/ACAGAG`	1	--	ut3¹ ese³		6		NS EA	498
rs184845240^1,2	C,	--	157876950(+)	`AGAAAC/TGAAGT`	1	--	ut3¹		0	--	--	--	--
rs190150368^1,2	C,	--	157876951(+)	`GAAACA/GAAGTG`	1	--	ut3¹		0	--	--	--	--
rs4648295^1,2	C,F,H,	--	157877099(-)	`AAAATG/ACTTAA`	1	--	ut3¹ ese³		7		NS EA NA	734
rs2853804^1,2	C,H	--	157877177(-)	`GATTTT/CCTGTT`	1	--	ut3¹ ese³		5		NS EA NA	386
rs193144472^1,2	C,	--	157877372(+)	`TGATAC/TAGATT`	1	--	ut3¹		0	--	--	--	--
rs4648294^1,2	H	--	157877456(-)	`GTGGAG/ACCACT`	1	--	ut3¹ ese³		5		NS EA	590
rs115973952^1,2	C,	--	157877512(+)	`GTCACA/TCTAAA`	1	--	ut3¹		1		NA	120
rs4648293^1,2	C,F,	--	157877575(-)	`CTACAA/GTTGCT`	1	--	ut3¹ ese³		3		NS WA	296
rs4648292^1,2	C,F,H,	--	157877624(-)	`AAAAAC/G/TAAGCT`	2	--	ut3¹		12		NS EA NA WA	912
rs5276^1,2	C,F,O,A,	--	157877755(-)	`TACCAG/ATAATT`	1	--	ut3¹ ese³		14		MN NS NA WA	1188
rs142234315^1,2	C,	--	157877884(+)	`AGATGC/TATTGG`	1	--	ut3¹		0	--	--	--	--
rs1051896^1,2	C	--	157877935(-)	`ACACTG/ATCACA`	1	--	ut3¹ ese³		8		MN NA	596
rs4648290^1,2	C,F,	--	157878006(-)	`GTTTTC/G/TACGTC`	2	--	ut3¹ ese³		1		NS	178
rs139462473^1,2	C,	--	157878043(+)	`AATAAA/CAACTG`	1	--	ut3¹		0	--	--	--	--
rs4648289^1,2	C,F,H	--	157878132(-)	`TACTCC/TTGTTG`	1	--	ut3¹ ese³		4		NS NA	332
rs3218625^1,2	C,F,H,	--	157878309(-)	`GCTCCG/AGACTA`	2	/R /G	mis¹ ese³		19		NA NS EA EU	3491
rs5274^1,2	C,F,H,	--	157878313(-)	`TCCCGC/ATCCGG`	2	/R	syn¹ ese³		21		MN NS EA NA	6484
rs5273^1,2	C,F,H,	--	157878536(-)	`AGAAGT/CTGGAG`	2	/A /V	mis¹		22		MN NA NS EA WA CSA EU	7456
rs4648288^1,2	C,F,	--	157878571(-)	`CCTCGG/ACCAGA`	2	/R	syn¹		3		NS NA EU	6031
rs5272^1,2	C,H	--	157878605(-)	`TGTGGA/GGCTGT`	2	E G	mis¹ ese³		13		MN NS EA NA	1090
rs189679860^1,2	C,	--	157878621(+)	`GATGTC/TACCAT`	2	N D	mis¹		0	--	--	--	--
rs200498625^1,2	C,	--	157878696(+)	`ACCAAC/TGTCAA`	1	--	int¹		0	--	--	--	--
rs4648287^1,2	C,F,	--	157878718(-)	`ACTGTT/CTTTTA`	1	--	int¹		4		NS WA	386
rs4648286^1,2	C,	--	157878727(-)	`AAGAAT/ACAAAC`	1	--	int¹		2		NS WA	280
rs11567827^1,2	C,F,	--	157878905(-)	`TAGACG/AGGGTT`	1	--	int¹		2		NS	92
rs4648285^1,2	C,F,	--	157878963(-)	`agtagC/Ttggga`	1	--	int¹		3		NS	248
rs4648283^1,2	C,F,	--	157879050(-)	`ACCCAG/AGCTGG`	1	--	int¹		5		NS NA	272
rs11567826^1,2	C,F,	--	157879076(-)	`TTTTCG/TAGATG`	1	--	int¹		3		NS CSA	94
rs4648281^1,2	C,	--	157879093(-)	`TGTTGT/CTTTTG`	1	--	int¹		1		NS	180
rs4648280^1,2	F	--	157879100(-)	`tgttt-/GTTT ttGTT`	1	--	int¹		1		NS	180
rs146262134^1,2	C	--	157879210(+)	`TTAAAA/GGACTG`	2	S	syn¹		1		NA	4550
rs139215497^1,2	C	--	157879248(+)	`GGAAGC/ACTGTG`	2	/A /S	mis¹		1		NA	4550
rs4648279^1,2	C,H	--	157879272(-)	`TTCCAC/G/TCCGCA`	3	P A S	mis¹ ese³		7		NS EA NA	588
rs13306034^1,2	H	--	157879387(-)	`GTTTCA/GGTTTT`	1	--	int¹		4		NS EA	416
rs4648278^1,2	C,F,	--	157879400(-)	`GTCTCC/TGCTGG`	1	--	int¹		10		NS WA	1038
rs4648277^1,2	C	--	157879563(-)	`AAAAAG/-TATCT`	1	--	int¹		1		NS	180
rs3218626^1,2	C,F	--	157879686(-)	`TTGCTA/-GTAAA`	1	--	int¹		2		NA NS	258
rs5279^1,2	C,F,O,	--	157879846(-)	`GAACAT/CGGAAT`	2	/H	syn¹		24		MN NS NA WA	6438
rs3218624^1,2	C,F,H,	--	157879855(-)	`ATATTG/ACTGGA`	2	/L	syn¹ ese³		5		NA NS	356
rs147906320^1,2	C,F	--	157879957(+)	`TTAAAT/CTCAGC`	2	/E	syn¹		1		NA	4550
rs3218623^1,2	C,F,H,	--	157880050(-)	`TATGTG/ACAACA`	2	/V	syn¹ ese³		5		NA NS	434
rs199520386^1,2	C	--	157880072(+)	`CAATCC/TTAATA`	2	K R	mis¹		0	--	--	--	--
rs201006741^1,2	C,	--	157880080(+)	`ATAGTC/TTCTCC`	2	E	syn¹		0	--	--	--	--
rs20434^1,2	C,H	--	157880120(-)	`AGATGC/TAATAA`	1	--	int¹		12		MN NS EA NA	836
rs5278^1,2	C,F,O,H,	--	157880437(-)	`TGCGAT/CGTGCT`	2	/D	syn¹		26		MN NA NS EA WA	7044
rs186230736^1,2	C,	--	157880596(+)	`GGATAC/TATCTC`	2	I M	mis¹		1		EU	1219
rs3218622^1,2	C,F,H,	--	157880773(-)	`ACAGCG/ATAAAC`	2	/H /R	mis¹ ese³		10		NA NS EA	934
rs20433^1,2	F	--	157881022(-)	`ATTCCT/CTTAAA`	1	--	int¹		1		--	78
rs16825745^1,2	F	--	157881208(-)	`ATGCCG/ACTTTC`	1	--	int¹		2		MN EA	356
rs4648274^1,2	C,F,H,	--	157881248(-)	`GCAAAA/CTGTTA`	1	--	int¹		26		NS EA NA WA	3082
rs16825748^1,2	F	--	157881312(-)	`ATATGT/AACAGG`	1	--	int¹		2		MN EA	356
rs4648273^1,2	C,F,H,	--	157881346(-)	`atgcaC/Tacaca`	1	--	int¹		9		NS EA CSA WA	792
rs11567825^1,2	C,	--	157881362(-)	`ATACAC/TACACA`	1	--	int¹		2		NS	90
rs4648271^1,2	C,F,	--	157881461(-)	`AGATAG/AATCCA`	1	--	int¹		1		NS	174
rs191294326^1,2	C,	--	157881514(+)	`GTATAA/GTTTTA`	1	--	int¹		0	--	--	--	--
rs20430^1,2	C,F	--	157881541(-)	`AAGATA/CGAGTT`	1	--	int¹		6		MN	426
rs140664948^1,2	C,	--	157881552(+)	`ACCCCA/GTGGCC`	2	H	syn¹		1		NA	4514
rs141500962^1,2	C	--	157881583(+)	`GCCCTC/TGCTTA`	2	Q R	mis¹		1		NA	4544
rs148479703^1,2	C,F	--	157881651(+)	`TTTGAG/ACCCTG`	2	/G	syn¹		2		NA EU	5871
rs142741435^1,2	C	--	157881726(+)	`TGCTTT/CTTACC`	2	/K	syn¹		1		NA	4524
rs4648270^1,2	C,F,H	--	157881872(-)	`ACCATA/CTCTTA`	1	--	int¹		6		NS NA	690
rs4648269^1,2	C,H	--	157881882(-)	`AAGTTG/TTTCCA`	1	--	int¹		7		NS EA NA	564
rs4648268^1,2	C,F,	--	157881906(-)	`aaataG/Aataaa`	1	--	int¹		9		NS NA	532
rs11567824^1,2	C,	--	157882009(-)	`AGTATG/AAGTCT`	1	--	int¹		2		NS	94
rs4648267^1,2	C,F,H,	--	157882035(-)	`CATGGT/ATATCT`	1	--	int¹		8		NS EA WA	792
rs4648266^1,2	C,H,	--	157882152(-)	`AGTAAG/AAAGAA`	1	--	int¹		8		NS EA NA WA	698
rs4648265^1,2	C,	--	157882186(-)	`GATGAT/CTGCCC`	2	/D	syn¹		3		NS NA	184
rs4648264^1,2	C,	--	157882222(-)	`CTCTCC/TTATTA`	2	S	syn¹ ese³		1		NS	180
rs20429^1,2	C,F,H	--	157882228(-)	`TCTAAC/TCTCTC`	2	N	syn¹ ese³		11		MN NS EA	1016
rs20428^1,2	C,F,	--	157882377(-)	`CATTTT/CACAAT`	1	--	int¹		7		MN NS	594
rs4648263^1,2	C,F,	--	157882841(-)	`AGATAG/CCTTTT`	1	--	int¹		10		NS MN WA	790
rs2066823^1,2	C,F,H,	--	157882925(-)	`TTAGCC/TTTCTC`	1	--	int¹		12		NA MN NS EA	1146
rs5277^1,2	C,F,O,H,	--	157882965(-)	`TATGTG/CTTGAC`	2	/V	syn¹		38		MN NA NS EA EU	8998
rs147896616^1,2	C	--	157882968(+)	`AACACA/GTAACT`	2	Y	syn¹		1		NA	4538
rs189809394^1,2	C,	--	157883084(+)	`TTTTAC/G/TTCTTG`	3	I L V	mis¹		0	--	--	--	--
rs20427^1,2	C,F,	--	157883123(-)	`TCCCTC/GCCTTT`	1	--	int¹ trp³		7		MN EA	562
rs2066824^1,2	C,F,H,	--	157883140(-)	`TGAGTC/ACCATT`	1	--	int¹		13		NA MN NS EA	1154
rs11567823^1,2	C,	--	157883185(-)	`GTGGGG/TCTGGA`	1	--	int¹		2		NS	90
rs200215667^1,2	C	--	157883265(+)	`CAATCG/ACACTT`	2	/C	syn¹		1		EU	1323
rs11567822^1,2	C,H	--	157883344(-)	`TTTAAT/ATGCAG`	1	--	int¹		8		NS EA NA	512
rs57950969^1,2	C	--	157883412(+)	`TGACTG/ATGAAT`	1	--	int¹		1		WA	2
rs4648262^1,2	C,F,H,	--	157883517(-)	`GAATAG/TAAAAT`	1	--	int¹		6		NS EA NA	662
rs111747544^1,2		--	157883536(+)	`GATAAC/TAGCAT`	1	--	int¹		1		CSA	2
rs4648261^1,2	C,F,H,	--	157883772(-)	`TTCTAG/ATCAGT`	1	--	int¹		18		NS EA NA	2020
rs4648260^1,2	C,H,	--	157883777(-)	`AAATAT/CTCTAG`	1	--	int¹		7		NS EA NA	576
rs4648259^1,2	C,F,H	--	157883793(-)	`TGGAAG/AAAGTT`	1	--	int¹		10		NS EA NA	1070
rs11567821^1,2	C,F,H,	--	157883866(-)	`AGGTTG/TTCATT`	1	--	int¹		17		NS EA NA	1932
rs11567820^1,2	C,	--	157883994(-)	`CCGCTA/GGAGTC`	1	--	int¹		2		NS	82
rs4648258^1,2	C,H	--	157884076(-)	`CCGCTC/GTGACC`	1	--	int¹		7		NS EA NA	588
rs3134591^1,2	C	--	157884193(-)	`CCGCTA/C/GCGATG`	2	--	ut5¹		0	--	--	--	--
rs183937640^1,2	C,	--	157884209(+)	`AGGGCG/TCGGCG`	1	--	ut5¹		0	--	--	--	--
rs11567819^1,2	C,F,H	--	157884253(-)	`CAGCTC/TCACAG`	1	--	ut5¹ ese³		10		NS EA NA	994
rs4648257^1,2	C,H,	--	157884308(-)	`CGACTT/AGCAGT`	1	--	ut5¹ ese³		5		NS EA	588
rs5271^1,2	C,F,	--	157884315(-)	`TGTCAT/GACGAC`	1	--	ut5¹ ese³		15		MN NA NS WA	944
rs20424^1,2	C,F,O,	--	157884386(-)	`ACAGTC/GATTTC`	1	--	us2k¹		20		MN NS NA	1446
rs5270^1,2	C,F,H,	--	157884487(-)	`CATTTC/GCGTGG`	1	--	us2k¹		16		MN NS EA WA	1296
rs20423^1,2	C,F	--	157884692(-)	`CCCGGT/CATCCC`	1	--	us2k¹		6		MN	434
rs20420^1,2	C,F,H,	--	157884836(-)	`TCTGTC/TCCGAC`	1	--	us2k¹		17		MN NS EA NA WA	1810
rs2734779^1,2	C,H	--	157884928(-)	`TATGTG/CCTGCA`	1	--	us2k¹		11		NS EA NA MN	826
rs20419^1,2	C,F,O,H,	--	157884931(-)	`ATGTAT/CGTGCT`	1	--	us2k¹		23		MN NS EA NA WA	2196
rs20418^1,2	C,F	--	157884979(-)	`GGNNN-/TAGCTATT`	1	--	us2k¹		9		MN NS	704
rs4648256^1,2	C,F,H,	--	157885038(-)	`GTATTT/CCTTCT`	1	--	us2k¹		15		NS MN EA NA	1262
rs11567815^1,2	C,H,	--	157885202(-)	`CGCTTC/GCTTTG`	1	--	us2k¹		11		NS MN EA	902
rs4648254^1,2	C,F,H	--	157885280(-)	`AATCCA/GCGCAT`	1	--	us2k¹		11		NS MN EA	1170
rs20416^1,2	C,H	--	157885309(-)	`ATCTCC/TTATGA`	1	--	us2k¹		12		MN NS EA NA	1010
rs20415^1,2	C,F,O,H,	--	157885456(-)	`GAATAG/AAAAAT`	1	--	us2k¹		20		MN NS EA NA WA	1848
rs3918304^1,2	C,F,H,	--	157885475(-)	`CAACTA/GTGTTC`	1	--	us2k¹		21		MN NS EA NA WA	2275
rs12027712^1,2	C,H	--	157885550(+)	`AACATC/TTATCA`	1	--	us2k¹		6		NS EA NA	422
rs78054612^1,2	C,	--	157885646(+)	`ATATAC/TACACA`	1	--	us2k¹		0	--	--	--	--
rs2223626^1,2	C,H	--	157885888(+)	`ATCTAG/AGAAGC`	1	--	us2k¹		6		NS EA NA	424
rs4648251^1,2	C,F,H,	--	157885912(-)	`AAATAT/GGACTA`	1	--	us2k¹		14		NS EA NA	1352
rs146578605^1,2		--	186640566(+)	`ATGATC/TTGCCC`	1	--	ds500¹		0	--	--	--	--
rs180672416^1,2		--	186640585(+)	`ATAATA/TTCCTC`	1	--	ds500¹		0	--	--	--	--
rs4648308^1,2	C,F,A,H,	--	186640617(-)	`GAAGGG/AGGCAC`	1	--	ds500¹		19		NS NA WA CSA EA	1302
rs190748919^1,2		--	186640638(+)	`TCTTAC/TTCTTT`	1	--	ds500¹		0	--	--	--	--
rs139126874^1,2		--	186640673(+)	`TTCTTC/GTAGAC`	1	--	ds500¹		0	--	--	--	--
rs149935897^1,2		--	186640692(+)	`GAAAAC/TAAGCT`	1	--	ds500¹		0	--	--	--	--
rs79035632^1,2	C,	--	186640703(+)	`TGTTTG/TCCATC`	1	--	ds500¹		4		NA WA EA	360
rs199550416^1,2		--	186640703(+)	`TGTTT-/GCCATCT`	1	--	ds500¹		0	--	--	--	--
rs4648306^1,2	C,F,A,H,	--	186640704(-)	`AGATGG/ACAAAC`	1	--	ds500¹		10		NS NA WA EA	630
rs182968257^1,2		--	186640796(+)	`GGAAGC/TCTCTA`	1	--	ds500¹		0	--	--	--	--
rs689470^1,2	C,F,A,H,	--	186641058(-)	`GTATGA/C/TGAATG`	2	--	ut3¹ ese³		35		MN NS EA NA WA CSA	3655
rs185983564^1,2		--	186641104(+)	`TGTTAA/GTAACA`	1	--	ut3¹		0	--	--	--	--
rs149091810^1,2	C,	--	186641116(+)	`TCAAG-/TTTTTT`	1	--	ut3¹		0	--	--	--	--
rs13306038^1,2	C	--	186641127(-)	`TTTTTA/TAAAAA`	1	--	ut3¹		0	--	--	--	--
rs689469^1,2	C,F,H,	--	186641197(-)	`TTTACG/ATTTAG`	1	--	ut3¹ ese³		17		NS EA NA CSA	2062
rs4648302^1,2	C,	--	186641218(-)	`CAGGAG/TAATCT`	1	--	ut3¹		3		NS NA	176
rs689468^1,2	C,F,H,	--	186641265(-)	`CTTTTG/AGGAAG`	1	--	ut3¹ trp³		13		NS NA CSA	1722
rs2853805^1,2	C,	--	186641626(-)	`TATATT/CTTCTT`	1	--	ut3¹ ese³		10		NA WA CSA EA	370
rs3835508^1,2	C,F,	--	186641629(-)	`CAGTAT/-ATCTT`	1	--	ut3¹		1		NS	158
rs11384450^1,2	C,	--	186641645(+)	`ATAAC-/AAAAAA`	1	--	ut3¹		0	--	--	--	--
rs4648298^1,2	C,F,H,	--	186641682(-)	`TATAAA/GCTGTG`	1	--	ut3¹		11		NS NA CSA	1414
rs192334329^1,2		--	186641840(+)	`TTTTGG/TTTTTA`	1	--	ut3¹		0	--	--	--	--
rs182127940^1,2		--	186641887(+)	`TTTTTC/TCAGTC`	1	--	ut3¹		0	--	--	--	--
rs187958342^1,2		--	186641919(+)	`CTGAGG/TCACTA`	1	--	ut3¹		0	--	--	--	--
rs150239498^1,2		--	186642389(+)	`ACTGCA/TAAATT`	1	--	ut3¹		0	--	--	--	--
rs2206593^1,2	C,F,O,H,	--	186642429(+)	`ATATCG/ATTATT`	1	--	ut3¹ ese³		41		NS NA EA WA CSA	3540
rs138908498^1,2		--	186642891(+)	`TTAAGA/GAATCA`	1	--	ut3¹		0	--	--	--	--
rs5275^1,2	C,F,A,H,	--	186643058(-)	`TTGGTC/TATTTT`	1	--	ut3¹		45		MN NS EA NA WA CSA	4859
rs36233646^1,2	C,	--	186643204(+)	`GTTCT-/TATAA TATAA`	1	--	ut3¹		1		CSA	2
rs180891120^1,2		--	186644120(+)	`CCTGGA/CTAACA`	1	--	int¹		0	--	--	--	--
rs4648284^1,2	C,F,	--	186644208(-)	`CCTCAA/GCTTCC`	1	--	int¹		5		NS CSA	252
rs4648282^1,2	C,F,	--	186644309(-)	`CTTTTC/TGAGAT`	1	--	int¹ trp³		3		NS	272
rs200185703^1,2		--	186644351(+)	`ACAAAA/CAACGA`	1	--	int¹		0	--	--	--	--
rs188076578^1,2		--	186644854(+)	`GTAGAC/TTAGAC`	1	--	int¹		0	--	--	--	--
rs201708424^1,2		--	186645119(+)	`TTGATA/GGTTGT`	2	H Y	mis¹		0	--	--	--	--
rs145051863^1,2		--	186645375(+)	`TCAAGC/TAACTG`	1	--	int¹		0	--	--	--	--
rs181994927^1,2		--	186645384(+)	`TGGAAG/TGCAAT`	1	--	int¹		0	--	--	--	--
rs4648276^1,2	C,F,H,	--	186645488(-)	`ACACAT/CTCTAT`	1	--	int¹		40		MN NS EA NA WA CSA	4228
rs201231411^1,2		--	186645852(+)	`TAAAA-/AAAT AAATA`	1	--	int¹		0	--	--	--	--
rs2066822^1,2	C,F	--	186645855(-)	`ATTTATTTA/- TTTTT`	1	--	int¹		4		NA NS	178
rs199545927^1,2		--	186645855(+)	`AAAAA-/TAAATA`	1	--	int¹		0	--	--	--	--
rs2066826^1,2	C,F,O,H,	--	186645927(-)	`TTACCG/ACTTAT`	1	--	int¹		29		NA NS EA WA CSA EU	3479
rs71634189^1,2	C	--	186645958(+)	`AAGGAG/AGCATA`	1	--	int¹		2		NA	4
rs200743316^1,2		--	186646058(+)	`AAAATA/GATGAA`	1	--	int¹		0	--	--	--	--
rs20432^1,2	C,F,O,A,	--	186646323(-)	`TTTTAT/GAATTA`	1	--	int¹		21		MN NS NA WA CSA EA	1249
rs149054401^1,2		--	186646407(+)	`AATAAG/TGCGGC`	1	--	int¹		0	--	--	--	--
rs191784606^1,2		--	186646409(+)	`TAATGC/TGGCAA`	1	--	int¹		0	--	--	--	--
rs183478129^1,2		--	186646503(+)	`TTAAAC/TTAAAA`	1	--	int¹		0	--	--	--	--
rs4648272^1,2	C,F,	--	186646587(-)	`ACACACA/-GACAT`	1	--	int¹		3		NS	264
rs186381971^1,2		--	186646590(+)	`TCTGTA/GTGTGT`	1	--	int¹		0	--	--	--	--
rs182375921^1,2		--	186647177(+)	`ATAATA/TTGAAA`	1	--	int¹		0	--	--	--	--
rs145859214^1,2		--	186647206(+)	`AAGACA/GCTCAT`	1	--	int¹		0	--	--	--	--
rs200569874^1,2		--	186647559(+)	`AAAAAC/TGTTTT`	1	--	int¹		0	--	--	--	--
rs138739859^1,2		--	186648024(+)	`ATGGGA/TCTAAA`	1	--	int¹		0	--	--	--	--
rs199619767^1,2		--	186648232(+)	`GGGAAG/TGTTAT`	2	I L	mis¹		0	--	--	--	--
rs144425750^1,2		--	186648983(+)	`CTTTCC/GTGGGA`	1	--	int¹		0	--	--	--	--
rs192915681^1,2		--	186649071(+)	`TATATA/TGATCA`	1	--	int¹		0	--	--	--	--
rs145315045^1,2		--	186649159(+)	`GGTTAA/GGTAAC`	1	--	int¹		0	--	--	--	--
rs185136094^1,2		--	186649216(+)	`AGTTCC/TTTCGA`	1	--	int¹		0	--	--	--	--
rs2745557^1,2	C,F,A,H,	--	186649221(+)	`TTTCGG/AACTCT`	1	--	int¹		35		NS EA NA WA CSA	3275
rs188057986^1,2		--	186649300(+)	`ACCCAC/GGAGGT`	1	--	int¹		0	--	--	--	--
rs191808038^1,2		--	186649335(+)	`CGTGGA/GACCGG`	1	--	int¹		0	--	--	--	--
rs200311765^1,2		--	186649366(+)	`AGGTAA/CTCACC`	1	--	int¹		0	--	--	--	--
rs188324228^1,2		--	186649668(+)	`CCTCTC/TCCCTT`	1	--	us2k¹		0	--	--	--	--
rs145516643^1,2		--	186649714(+)	`TTTACA/CCACGG`	1	--	us2k¹		0	--	--	--	--
rs180835304^1,2		--	186650048(+)	`TAGAGA/GGTCGA`	1	--	us2k¹		0	--	--	--	--
rs148416467^1,2	C,	--	186650210(+)	`AATAG-/CTACTACC`	1	--	us2k¹		0	--	--	--	--
rs20417^1,2	C,F,H,	--	186650321(-)	`TTCCCG/CCCTCT`	1	--	us2k¹ tfbs³		27		NS EA NA MN WA CSA	2156
rs185570083^1,2		--	186650435(+)	`AAAGGA/GAGCGG`	1	--	us2k¹		0	--	--	--	--
rs190474242^1,2		--	186650461(+)	`GCAGGA/GACGCT`	1	--	us2k¹		0	--	--	--	--
rs181791571^1,2		--	186650514(+)	`GCGTGG/TATTAT`	1	--	us2k¹		0	--	--	--	--
rs186859176^1,2		--	186650577(+)	`AAGTTC/TACTCT`	1	--	us2k¹		0	--	--	--	--
rs138439801^1,2		--	186650609(+)	`TCCAAA/GATTAT`	1	--	us2k¹		0	--	--	--	--
rs191512388^1,2		--	186650695(+)	`ATTCTA/CGTTTT`	1	--	us2k¹		0	--	--	--	--
rs689466^1,2	C,F,O,H,	--	186650751(-)	`TTCCAA/GCTGTC`	1	--	us2k¹		47		NS EA NA WA	4980
rs689465^1,2	C,F,	--	186650846(-)	`CACATA/GTACAT`	1	--	us2k¹ tfbs³		9		NS NA WA	498
rs11567814^1,2	C,F	--	186650877(-)	`TTCTGGT/-GTGTG`	1	--	us2k¹		3		NS CSA	94
rs72366725^1,2	C,	--	186650877(+)	`TATAT-/ACACACA`	1	--	us2k¹		0	--	--	--	--
rs689463^1,2	C,	--	186650999(-)	`AGACTT/-CTACA`	1	--	us2k¹		1		NS	172
rs181400790^1,2		--	186650999(+)	`TGTAGA/TAGTCT`	1	--	us2k¹		0	--	--	--	--
rs115215683^1,2	F,	--	186651032(+)	`GACTCA/GCTTGG`	1	--	us2k¹		1		WA	118
rs689462^1,2	C,F,H,	--	186651083(-)	`TCATGA/CAGAAT`	1	--	us2k¹		30		NS EA NA WA CSA	3372
rs4648250^1,2	C,F,H,	--	186651296(-)	`ACTTCA/GAATTT`	1	--	us2k¹ tfbs³		23		NS EA NA	2580
rs201529345^1,2	--	--	157882935(+)	`AAAACC/TTTAGA`	1	--	int¹		0	--	--	--	--
rs200779240^1,2	--	--	157876457(+)	`TATAAC/GCATAG`	1	--	ut3¹		0	--	--	--	--
rs200479241^1,2	--	--	157879973(+)	`TACGAC/TTTTGG`	2	N S	mis¹		0	--	--	--	--
rs201104814^1,2	--	--	157877540(+)	`TGAAAA/CAGGAA`	1	--	ut3¹		0	--	--	--	--
rs200030471^1,2	--	--	157878538(+)	`CCAACA/TTCTAC`	2	E D	mis¹		0	--	--	--	--
rs199629276^1,2	--	--	157877820(+)	`GACAGA/CAAAAT`	1	--	ut3¹		0	--	--	--	--
rs200652624^1,2	--	--	157879207(+)	`TCATTA/GAAAGA`	2	F	syn¹		0	--	--	--	--
rs201232393^1,2	--	--	157880714(+)	`TCTTAA/GTAGTC`	1	--	int¹		0	--	--	--	--
rs200132172^1,2	--	--	157882987(+)	`CATTTC/TGAAGG`	2	Q R	mis¹		0	--	--	--	--
rs200408009^1,2	--	--	157878572(+)	`CTGGCA/CGAGGC`	2	R L	mis¹		0	--	--	--	--
rs201772944^1,2	--	--	157878311(+)	`GTCCGG/TAGCGG`	2	Y S	mis¹		0	--	--	--	--
rs200883517^1,2	--	--	157876113(+)	`CCCACA/GGTGCT`	1	--	ut3¹		0	--	--	--	--
rs200089522^1,2	--	--	157879237(+)	`CTCTGA/GTCAAT`	2	D	syn¹		0	--	--	--	--
rs200536698^1,2	--	--	157878126(+)	`TCTCCA/GCAACA`	1	--	ut3¹		0	--	--	--	--
rs2853803^1,2	--	--	157879325(-)	`ATTCTG/TGTTTT`	1	--	int¹		0	--	--	--	--
rs201377863^1,2	--	--	157876571(+)	`TATTAG/TTATTG`	1	--	ut3¹		0	--	--	--	--
rs200207384^1,2	--	--	157877651(+)	`TAATAA/TCTTTA`	1	--	ut3¹		0	--	--	--	--
rs199657133^1,2	--	--	157877361(+)	`GACCCC/TTTTGC`	1	--	ut3¹		0	--	--	--	--
rs201583472^1,2	--	--	157882311(+)	`TGAAAA/TTTTCA`	1	--	int¹		0	--	--	--	--
rs200828213^1,2	--	--	157876593(+)	`TTAGAG/TATCAT`	1	--	ut3¹		0	--	--	--	--
rs201917851^1,2	--	--	157877854(+)	`AAACAC/TTAGTT`	1	--	ut3¹		0	--	--	--	--
rs199526797^1,2	--	--	157882922(+)	`TTTGAA/GAAGGC`	1	--	int¹		0	--	--	--	--
rs201360946^1,2	--	--	157876166(+)	`AACGAA/GGCATC`	1	--	ut3¹		0	--	--	--	--
rs200843740^1,2	--	--	157880045(+)	`TCAAGC/TGTTGC`	2	H R	mis¹		0	--	--	--	--
rs201616417^1,2	--	--	157880605(+)	`TCTCCA/GTCAAT`	2	D	syn¹		0	--	--	--	--
rs200232733^1,2	--	--	157878168(+)	`AGTAAC/TATAAG`	1	--	ut3¹		0	--	--	--	--
rs201238205^1,2	--	--	157876771(+)	`ATAAGC/TGTATA`	1	--	ut3¹		0	--	--	--	--
rs201405348^1,2	--	--	157878573(+)	`TGGCCA/GAGGCT`	2	R W	mis¹		0	--	--	--	--
rs201346673^1,2	--	--	157879340(+)	`GGCATA/GTTTAC`	1	--	int¹		0	--	--	--	--
rs201078559^1,2	--	--	157879122(+)	`AAAAAC/TGAAGA`	1	--	int¹		0	--	--	--	--
rs201807501^1,2	--	--	157884136(+)	`GTACTA/CACCTG`	1	--	int¹		0	--	--	--	--
rs61757788^1,2	--	--	157879171(+)	`GATTCA/GTAGGG`	2	Y	syn¹		0	--	--	--	--
rs201912060^1,2	--	--	157884161(+)	`AGGACA/CGCGCA`	2	A	syn¹		0	--	--	--	--
rs199859157^1,2	--	--	157877169(+)	`AACTGC/TACAAC`	1	--	ut3¹		0	--	--	--	--
rs55864097^1,2	--	--	157885635(+)	`TATACA/CTATAT`	1	--	us2k¹		0	--	--	--	--
rs201938310^1,2	--	--	157882216(+)	`CTAGTA/GTAATA`	2	Y	syn¹		0	--	--	--	--
rs201534244^1,2	--	--	157878196(+)	`TATTAA/GATAAT`	1	--	ut3¹		0	--	--	--	--
rs200536996^1,2	--	--	157884287(+)	`CTGGAC/TGTGCT`	1	--	ut5¹		0	--	--	--	--
rs201084591^1,2	--	--	157882353(+)	`TTAAGA/TAAATC`	1	--	int¹		0	--	--	--	--
rs200097577^1,2	--	--	157876109(+)	`AAAACA/CCACAG`	1	--	ut3¹		0	--	--	--	--
rs199504824^1,2	--	--	157880557(+)	`GGGTAA/GATCAT`	2	I	syn¹		0	--	--	--	--
rs3134589^1,2	--	--	157877591(-)	`ATCAGA/TTGAAA`	1	--	ut3¹		0	--	--	--	--
rs199738725^1,2	--	--	157878223(+)	`GTTCAC/TATAAA`	1	--	ut3¹		0	--	--	--	--
rs201906674^1,2	--	--	157882983(+)	`ATTGCA/GTTTCG`	2	N	syn¹		0	--	--	--	--
rs12759220^1,2	--	--	157881794(+)	`GACTGG/TCAATC`	1	--	int¹		0	--	--	--	--
rs145215600^1,2	--	--	186648216(+)	`TTGCAT/CTTCGA`	2	/N /S	mis¹		1		NA	4540
rs71828189^1,2	--	--	186645854(+)	`AATAA-/ATAA ATAAA`	1	--	int¹		0	--	--	--	--
rs200589642^1,2	--	--	157882131(+)	`AGTTAA/CTACAT`	1	--	int¹		0	--	--	--	--
rs199626392^1,2	--	--	157880619(+)	`CTAAAA/TAAATA`	1	--	int¹		0	--	--	--	--
rs199612975^1,2	--	--	157881738(+)	`GAAAAA/GTGAGA`	1	--	int¹		0	--	--	--	--
rs199709318^1,2	--	--	157880043(+)	`ACTCAA/GGTGTT`	2	L	syn¹		0	--	--	--	--
rs201745115^1,2	--	--	157877635(+)	`GGTATA/GTGTAC`	1	--	ut3¹		0	--	--	--	--
rs199874895^1,2	--	--	157883108(+)	`TGCAAA/GAAGAC`	1	--	int¹		0	--	--	--	--
rs199630699^1,2	--	--	157884270(+)	`GCGCTA/GCTGAG`	1	--	ut5¹		0	--	--	--	--
rs200081470^1,2	--	--	157878397(+)	`TTCACA/GTTATT`	2	N	syn¹		0	--	--	--	--
rs199506254^1,2	--	--	157877754(+)	`AAATTA/GCTGGT`	1	--	ut3¹		0	--	--	--	--
rs199505687^1,2	--	--	157876582(+)	`CTGAGA/TACTAC`	1	--	ut3¹		0	--	--	--	--
rs200400596^1,2	--	--	157877313(+)	`TGAACA/C/TATAAT`	2	--	ut3¹		0	--	--	--	--
rs199850911^1,2	--	--	157876397(+)	`AAGATA/G/TTACTG`	2	--	ut3¹		0	--	--	--	--
rs199740331^1,2	--	--	157877874(+)	`GCATCA/CTGGAA`	1	--	ut3¹		0	--	--	--	--
rs201432087^1,2	--	--	157882137(+)	`TACATC/TTCTAA`	1	--	int¹		0	--	--	--	--
rs200795899^1,2	--	--	157877444(+)	`AGATAA/GCACTG`	1	--	ut3¹		0	--	--	--	--
rs199824454^1,2	--	--	157875836(+)	`CACAAC/TCCAAA`	1	--	ut3¹		0	--	--	--	--
rs201348126^1,2	--	--	157875874(+)	`TTAATA/GACAAA`	1	--	ut3¹		0	--	--	--	--
rs200314986^1,2	--	--	157882252(+)	`CTTTTA/G/TTAGCC`	3	* Y	stg¹ syn¹		0	--	--	--	--
rs199751949^1,2	--	--	157880687(+)	`ATATGA/GGTATA`	1	--	int¹		0	--	--	--	--
rs200786963^1,2	--	--	157878069(+)	`AGCAAC/GAGCAA`	1	--	ut3¹		0	--	--	--	--
rs199661060^1,2	--	--	157883255(+)	`TGTCCA/GGGTAC`	2	R W	mis¹		0	--	--	--	--
rs201042127^1,2	--	--	157877114(+)	`AGGTAC/TTTTAT`	1	--	ut3¹		0	--	--	--	--
rs202217156^1,2	--	--	157876802(+)	`TTTTTC/TCTCTT`	1	--	ut3¹		0	--	--	--	--
rs200140544^1,2	--	--	157884181(+)	`GGCGCC/GGGCGA`	2	R G	mis¹		0	--	--	--	--
rs200579714^1,2	--	--	157879099(+)	`CAACAA/CAAACA`	1	--	int¹		0	--	--	--	--
rs200428982^1,2	--	--	157875885(+)	`TCAAGG/TTTTTT`	1	--	ut3¹		0	--	--	--	--
rs200408499^1,2	--	--	157883125(+)	`AGGGAA/GGGAGA`	1	--	int¹		0	--	--	--	--
rs201605778^1,2	--	--	157882113(+)	`CAATGA/CAGCCC`	1	--	int¹		0	--	--	--	--
rs201933308^1,2	--	--	157883177(+)	`TAACTC/GTATCC`	1	--	int¹		0	--	--	--	--
rs199972508^1,2	--	--	157882198(+)	`GGCACA/GGGAGG`	2	P	syn¹		0	--	--	--	--
rs199515990^1,2	--	--	157879125(+)	`AACGAA/CGAAGT`	1	--	int¹		0	--	--	--	--
rs200279549^1,2

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PTGS2 Gene

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H...

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Export list of displayed genes

PTGS2 Gene

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H...

Aliasesfor PTGS2 gene

Summariesfor PTGS2 gene

Genomic Viewsfor PTGS2 gene

Proteinsfor PTGS2 gene

Protein Domains /Familiesfor PTGS2 gene

Functionfor PTGS2 gene

Pathways & Interactionsfor PTGS2 gene

Drugs & Compoundsfor PTGS2 gene

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Expression for PTGS2 gene

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for PTGS2 gene

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for PTGS2 gene

Proteins
for PTGS2 gene

Protein Domains /
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for PTGS2 gene

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for PTGS2 gene

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for PTGS2 gene

Genomic Variants
for PTGS2 gene