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PTGS2 Gene

protein-coding   GIFtS: 74
GCID: GC01M186640

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H...

Microbiology & Infectious Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase And
Cyclooxygenase)1 2
Prostaglandin H2 Synthase 22 3     PHS-22
COX-22 3     Cyclooxygenase 2b2
COX22 3     hCox-22
PGHS-22 3     Prostaglandin G/H Synthase 22
PGH Synthase 22 3     Cyclooxygenase-23
PHS II2 3     Prostaglandin-Endoperoxide Synthase 23
EC 8     EC 1.14.998

External Ids:    HGNC: 96051   Entrez Gene: 57432   Ensembl: ENSG000000737567   OMIM: 6002625   UniProtKB: P353543   

Export aliases for PTGS2 gene to outside databases

Previous GC identifers: GC01M184166 GC01M182068 GC01M183160 GC01M183879 GC01M183372 GC01M184907 GC01M157875

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGS2 Gene:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin
biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive
PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene
encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible
for the prostanoid biosynthesis involved in inflammation and mitogenesis. (provided by RefSeq, Feb 2009)

GeneCards Summary for PTGS2 Gene: 
PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)) is a protein-coding gene. Diseases associated with PTGS2 include bile duct cysts, and acute generalized exanthematous pustulosis, and among its related super-pathways are Prostaglandin 2 biosynthesis and metabolism FM and Arachidonic acid metabolism. GO annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is PTGS1.

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354
Function: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of
inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

summary for PTGS2 Gene:
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is
expressed in cells in three isoforms: COX-1, COX-2 and COX-3. COX-1 (constitutive) and COX-2 (inducible)
isoforms catalyze the rate-limiting step of prostaglandin production and are the targets of non-steroidal
anti-inflammatory drugs. COX-3 does not appear to be involved in inflammatory processes, but seems to be
involved in pain and fever. COX-3 is thought to be derived through the retention of the highly structured G
+ C-rich intron 1 of the COX-1 gene.

Gene Wiki entry for PTGS2 Gene

PharmGKB "VIP" summary for PTGS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGS2 gene promoter:
         AP-1   ATF-2   POU6F1 (c2)   STAT5A   CREB   deltaCREB   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTGS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGS2

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2-q25.3   Ensembl cytogenetic band:  1q31.1   HGNC cytogenetic band: 1q25.2-q25.3

PTGS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M186640:  view genomic region     (about GC identifiers)

186,640,923 bp from pter      End:
186,649,559 bp from pter
8,637 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354 (See protein sequence)
Recommended Name: Prostaglandin G/H synthase 2 precursor  
Size: 604 amino acids; 68996 Da
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)
Subunit: Homodimer (By similarity)
Subcellular location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral
membrane protein
Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase
Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin
1 PDB 3D structure from and Proteopedia for PTGS2:
1V0X (3D)    
Secondary accessions: A8K802 Q16876

Explore the universe of human proteins at neXtProt for PTGS2: NX_P35354

Explore proteomics data for PTGS2 at MOPED 

Post-translational modifications:

  • UniProtKB: S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues
    in addition to Cys-561
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35354

  • 4/30 DME Specific Peptides for PTGS2 (P35354) (see all 30)

    PTGS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGS2 Protein Expression
    REFSEQ proteins: NP_000954.1  
    ENSEMBL proteins: 
     ENSP00000356438   ENSP00000454130  
    Reactome Protein details: P35354
    Human Recombinant Protein Products for PTGS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PTGS2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PTGS2
    GenScript Custom Purified and Recombinant Proteins Services for PTGS2
    Novus Biologicals PTGS2 Proteins
    Novus Biologicals PTGS2 Lysates
    Sino Biological Recombinant Protein for PTGS2
    Sino Biological Cell Lysate for PTGS2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGS2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043005neuron projection IDA12355421
    GO:0043234protein complex IEA--

    PTGS2 for ontologies           About GeneDecksing

    PTGS2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGS2
    R&D Systems Antibodies for PTGS2 (COX-2)
    Cell Signaling Technology (CST) Antibodies for PTGS2  (COX-2)
    OriGene Antibodies for PTGS2
    OriGene Custom Antibody Services for PTGS2
    GenScript Custom Superior Antibodies Services for PTGS2
    Novus Biologicals PTGS2 Antibodies
    Abcam antibodies for PTGS2
    Cloud-Clone Corp. Antibodies for PTGS2 
    ThermoFisher Antibodies for PTGS2
    LSBio Antibodies in human, mouse, rat for PTGS2 

    Assay Products for PTGS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTGS2
    R&D Systems ELISAs for PTGS2 (COX-2)         (see all)
    GenScript Custom Assay Services for PTGS2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PTGS2 (COX-2)
    Enzo Life Sciences assays for PTGS2
    Cloud-Clone Corp. ELISAs for PTGS2 
    Cloud-Clone Corp. CLIAs for PTGS2

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: COX-2  

    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR010255 Haem_peroxidase
     IPR019791 Haem_peroxidase_animal_subgr
     IPR002007 Haem_peroxidase_animal

    Graphical View of Domain Structure for InterPro Entry P35354

    ProtoNet protein and cluster: P35354

    3 Blocks protein domains:
    IPB002007 Animal haem peroxidase signature
    IPB006210 Type I EGF
    IPB010255 Haem peroxidase

    UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354
    Similarity: Belongs to the prostaglandin G/H synthase family
    Similarity: Contains 1 EGF-like domain

    PTGS2 for domains           About GeneDecksing

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGH2_HUMAN, P35354
    Function: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of
    inflammation and/or a role for prostanoid signaling in activity-dependent plasticity
    Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=16.2 uM for arachidonate (in absence of sodium nitroprusside
    NO donor); KM=17.0 uM for arachidonate (in presence of sodium nitroprusside NO donor); Vmax=81.3 nmol/min/mg
    enzyme (in absence of sodium nitroprusside NO donor); Vmax=132 nmol/min/mg enzyme (in absence of sodium
    nitroprusside NO donor);
    Induction: By cytokines and mitogens

         Genatlas biochemistry entry for PTGS2:
    prostaglandin G/H synthase 2,mitogen and cytokine inducible form (lipocalin family,Kernel group),monomer,potent
    mediator of inflammation,playing a minor role in colorectal carcinogenesis,overexpressed in squamous cell
    carcinoma of the head and neck,putatively involved in the tumor tissue response to necrosis

         Enzyme Numbers (IUBMB): EC 2 EC 1.14.992

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity NAS14511332
    GO:0004666prostaglandin-endoperoxide synthase activity IDA1380156
    GO:0005515protein binding ----
    GO:0008289lipid binding IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    PTGS2 for ontologies           About GeneDecksing

         15/25 MGI mutant phenotypes (inferred from 13 alleles(MGI details for Ptgs2) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    PTGS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTGS2: Ptgs2tm1Unc Ptgs2tm2(Ptgs1)Fun Ptgs2tm3Fun Ptgs2tm1Jed

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGS2 

    miRTarBase miRNAs that target PTGS2:
    hsa-mir-101 (MIRT004297), hsa-let-7b (MIRT001603), hsa-mir-16 (MIRT001426), hsa-mir-26b (MIRT004659)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGS2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGS2 (see all 23):
    hsa-miR-4291 hsa-miR-576-3p hsa-miR-624* hsa-miR-1297 hsa-miR-144 hsa-miR-629* hsa-miR-558 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidPTGS2 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGS2

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for PTGS2
    Sirion Biotech Customized adenovirus for overexpression of PTGS2

    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTGS2 (see all 8)
    OriGene ORF clones in mouse, rat for PTGS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGS2 (NM_000963)
    Sino Biological Human cDNA Clone for PTGS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS2
    Sirion Biotech Customized lentivirus for stable overexpression of PTGS2 
                         Customized lentivirus expression plasmids for stable overexpression of PTGS2 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for PTGS2
    Search LifeMap BioReagents cell lines for PTGS2
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTGS2 About   (see all 46)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.42
    C20 prostanoid biosynthesis0.40
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    Arachidonic acid metabolism0.44
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    4PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    all-trans-Retinoic Acid Signaling in Brain0.71
    MIF Regulation of Innate Immune Cells0.94
    Endothelin-1 Signaling Pathway0.46
    5aspirin triggered resolvin E biosynthesis
    aspirin triggered resolvin E biosynthesis0.67
    aspirin triggered resolvin D biosynthesis0.67
    aspirin-triggered lipoxin biosynthesis0.67

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for PTGS2 (see all 9)
        Development HGF signaling pathway
    Prostaglandin 2 biosynthesis and metabolism FM
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    HETE and HPETE biosynthesis and metabolism

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTGS2 (see all 13)
        MIF Regulation of Innate Immune Cells
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    HGF Pathway
    Endothelin-1 Signaling Pathway
    Colorectal Cancer Metastasis

    3 Cell Signaling Technology (CST) Pathways for PTGS2
    NF-kappaB Signaling

    5/10 GeneGo (Thomson Reuters) Pathways for PTGS2 (see all 10)
        HETE and HPETE biosynthesis and metabolism
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Development VEGF signaling via VEGFR2 - generic cascades
    Transcription PPAR Pathway

    5/13 BioSystems Pathways for PTGS2 (see all 13)
        Eicosanoid Synthesis
    Selenium Pathway
    Prostaglandin Synthesis and Regulation
    C20 prostanoid biosynthesis
    aspirin triggered resolvin E biosynthesis

    5        Reactome Pathways for PTGS2
    Arachidonic acid metabolism
    Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Metabolism of lipids and lipoproteins

    3 PharmGKB Pathways for PTGS2
        Acetaminophen Pathway, Pharmacokinetics
    Celecoxib Pathway, Pharmacodynamics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics

    5/13         Kegg Pathways  (Kegg details for PTGS2) (see all 13):
        Arachidonic acid metabolism
    Metabolic pathways
    NF-kappa B signaling pathway
    VEGF signaling pathway
    TNF signaling pathway

    UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354
    Pathway: Lipid metabolism; prostaglandin biosynthesis

    PTGS2 for pathways           About GeneDecksing


        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for PTGS2 (P353543 ENSP000003564384) via UniProtKB, MINT, STRING, and/or I2D (see all 85)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958703, ENSP000003792824I2D: score=1 STRING: ENSP00000379282
    ENSG00000206403O958703I2D: score=1 
    ENSG00000224552O958703I2D: score=1 
    ENSG00000230475O958703I2D: score=1 
    ENSG00000231488O958703I2D: score=1 
    About this table

    Gene Ontology (GO): 5/66 biological process terms (GO ID links to tree view) (see all 66):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process NAS--
    GO:0001525angiogenesis IEA--
    GO:0006693prostaglandin metabolic process TAS9630216
    GO:0006928cellular component movement TAS9630216
    GO:0006954inflammatory response IEA--

    PTGS2 for ontologies           About GeneDecksing

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGS2 for compounds           About GeneDecksing

    EMD Millipore small molecules for PTGS2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PTGS2

    Compounds for PTGS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CelecoxibSelective cyclooxygenase-2 (COX-2) inhibitor[169590-42-5]
    ResveratrolCyclooxygenase inhibitor[501-36-0]
    NS 398Cyclooxygenase-2 (COX-2) inhibitor[123653-11-2]
    SC 58125Selective cyclooxygenase-2 (COX-2) inhibitor[162054-19-5]
    IndomethacinCyclooxygenase inhibitor (COX-1 > COX-2)[53-86-1]

    10/16 HMDB Compounds for PTGS2 (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    11R-HEPE11(R)-hydroxyeicosa-5Z,8Z,12E,14Z,17Z-pentaenoate (see all 2)----
    Acetaminophen4'-Hydroxyacetanilide (see all 629)103-90-2--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Aspirin2-(Acetyloxy)benzoic acid (see all 59)50-78-2--
    CelecoxibCelebrex (see all 3)169590-42-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Ibuprofenalpha-(4-Isobutylphenyl)propionate (see all 9)15687-27-1--
    IronArmco iron (see all 19)7439-89-6--
    Naproxen(+)-(S)-Naproxen (see all 49)22204-53-1--
    OxygenOxygen (see all 5)7782-44-7--

    10/72 DrugBank Compounds for PTGS2 (see all 72)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RofecoxibMK 966 (see all 2)162011-90-7targetinhibitor10566562 20724158 10555907 10693877 11752352 18922570 20166930 11398914 10643177 10580458
    FlurbiprofenFLP (see all 5)5104-49-4targetinhibitor19066416 17562170 10091674 10773011 10977131 11006278 11405284
    IbuprofenIbuprophen (see all 3)15687-27-1targetinhibitor15494133 15556152 14510637 11752352 12852704 15481334
    enzymeinhibitor15494133 15556152 14510637 11752352 12852704 15481334 22668799
    Valdecoxib-- 181695-72-7targetinhibitor11060833 12564662 12167567 10715145 11752352 12644588 15494548
    Acetylsalicylic acid2-Acetoxybenzenecarboxylic acid (see all 24)50-78-2targetinhibitor17033106 17301265 17258197 11752352 17037745 17181859
    Antrafenine-- 55300-30-6targetinhibitor17604186 17612049 17607546 11752352 17532719 17521299
    Carprofen2-(6-Chloro-9H-carbazol-2-yl)propanoic acid (see all 6)53716-49-7targetinhibitor15198222 11703020 10895904 17181139 15939622 11752352
    Celecoxib-- 169590-42-5targetinhibitor12055598 12093311 12104042 11752352 12086402 12086292
    Diflunisal-- 22494-42-4targetinhibitor8737748 11673972 10825891 11752352 11315375 12852483
    Etodolac-- 41340-25-4targetinhibitor15198222 11009046 11752352 12824918 10594327 11275997

    7 IUPHAR Ligands for PTGS2 (COX-2 )    About this table 
    LigandTypeActionAffinityPubmed IDs

    10/117 Novoseek inferred chemical compound relationships for PTGS2 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    celecoxib 97 1888 18230053 (7), 18766003 (7), 15014359 (6), 16230415 (6) (see all 99)
    rofecoxib 96 933 20110006 (10), 10411562 (6), 17620346 (5), 17636557 (4) (see all 99)
    pge2 94.8 3923 18727513 (9), 19452719 (9), 12493746 (8), 16585602 (7) (see all 99)
    prostaglandin 92.7 1317 10735591 (5), 10692251 (4), 9016346 (4), 8063757 (3) (see all 99)
    ns 398 92.2 312 14630280 (5), 15703831 (4), 15382039 (4), 19956533 (4) (see all 99)
    valdecoxib 91.6 196 15494548 (6), 17605893 (3), 18171312 (3), 17429597 (3) (see all 99)
    etoricoxib 89.3 163 11160644 (5), 12817520 (4), 15827069 (3), 19392653 (3) (see all 99)
    arachidonic acid 88.4 747 9373167 (6), 9461572 (5), 9973312 (4), 9031736 (4) (see all 99)
    nimesulide 88.3 372 18333314 (5), 18288985 (5), 19152549 (4), 14977856 (4) (see all 99)
    meloxicam 87.8 275 16245223 (4), 12911075 (3), 19078323 (3), 10812057 (3) (see all 99)

    3 PharmGKB related drug/compound annotations for PTGS2 gene    About this table
    Drug/compound PharmGKB Annotation

    Search CenterWatch for drugs/clinical trials and news about PTGS2 / PGH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTGS2 gene: 

    Unigene Cluster for PTGS2:

    Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    Hs.196384  [show with all ESTs]
    Unigene Representative Sequence: NM_000963
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367468(uc001gsb.3 uc009wyo.3) ENST00000490885 ENST00000559627
    ENST00000466691 ENST00000559800
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGS2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGS2 (see all 23):
    hsa-miR-4291 hsa-miR-576-3p hsa-miR-624* hsa-miR-1297 hsa-miR-144 hsa-miR-629* hsa-miR-558 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidPTGS2 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGS2
    OriGene clones in human, mouse for PTGS2 (see all 8)
    OriGene ORF clones in mouse, rat for PTGS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGS2 (NM_000963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS2
    Sirion Biotech Customized lentivirus for stable overexpression of PTGS2 
                         Customized lentivirus expression plasmids for stable overexpression of PTGS2 
    OriGene qPCR primer pairs and template standards for PTGS2
    OriGene qSTAR qPCR primer pairs in human, mouse for PTGS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGS2

    Additional mRNA sequence: 

    AJ634912.1 AK292167.1 AY151286.1 AY462100.1 BC013734.1 HM473188.1 L15326.1 M90100.1 

    3 DOTS entries:

    DT.413375  DT.91935010  DT.121406567 

    24/101 AceView cDNA sequences (see all 101):

    D58162 AA296431 AA644211 BG236304 CB143773 AY462100 BC013734 BG152882 
    BQ100700 CK823043 CD365731 CK823042 BP335244 CB960307 BM978796 BQ722004 
    BQ100978 AL710813 AJ634912 BX363285 AA371396 BM128780 AA593850 BQ002136 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTGS2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                                                                                -                     
    SP2:                                                  -                             -                     
    SP3:                                                                                -                     

    ECgene alternative splicing isoforms for PTGS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGS2 expression in normal human tissues (normalized intensities)      PTGS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    PTGS2 Expression
    About this image

    PTGS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     Epithelium (Uncategorized)    fully expand to see all 5 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Wharton's jelly-derived stem cells
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Human corneal endothelial cells
             Human Keratocyte (HK)   
     Lung (Respiratory System)    fully expand to see all 3 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   

    See PTGS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGS2

    SOURCE GeneReport for Unigene cluster: Hs.196384
        SABiosciences Expression via Pathway-Focused PCR Arrays including PTGS2 (see all 25): 
              Lung Cancer in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    OriGene qPCR primer pairs and template standards for PTGS2
    OriGene qSTAR qPCR primer pairs in human, mouse for PTGS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGS2
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PTGS2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Ptgs21 , 5 prostaglandin-endoperoxide synthase 21, 5 84.77(n)1
      1 (63.84 cM)5
    192251  NM_011198.31  NP_035328.21 
    (Gallus gallus)
    Aves PTGS21 prostaglandin-endoperoxide synthase 2 (prostaglandin more 77.61(n)
      396451  NM_001167719.1  NP_001161191.1 
    (Anolis carolinensis)
    Reptilia PTGS26
    Uncharacterized protein
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.333292 Xenopus laevis transcribed sequence with moderate similarity more 75.65(n)    CA988090.1 
    (Danio rerio)
    Actinopterygii ptgs22 prostaglandin-endoperoxide synthase 2 75.55(n)   246227  AY028585.1 

    ENSEMBL Gene Tree for PTGS2 (if available)
    TreeFam Gene Tree for PTGS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
    About This Section
    Paralogs for PTGS2 gene
    2 SIMAP similar genes for PTGS2 using alignment to 3 protein entries:     PGH2_HUMAN (see all proteins):
    COX-2    PTGS1

    PTGS2 for paralogs           About GeneDecksing

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/516 SNPs in PTGS2 are shown (see all 516)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 1 posSequence#AA
    C--186646588(+) TGTGT-/GTATAAT 1 -- int10--------
    C--186650999(-) AGACTT/-CTACA 1 -- us2k11Minor allele frequency- -:0.01NS 172
    C,F,H--193187485(-) cctctA/Gtcctt 1 -- ds500122Minor allele frequency- G:0.02NS EA NA 2134
    --193187526(+) ATGATC/TTGCCC 1 -- ds50010--------
    --193187545(+) ATAATA/TTCCTC 1 -- ds50010--------
    C,F--193187574(-) GGGGGC/GACAAA 1 -- ds50011Minor allele frequency- G:0.01NS 180
    C,F,A,H--193187577(-) GAAGGG/AGGCAC 1 -- ds500119Minor allele frequency- A:0.29NS NA WA CSA EA 1302
    --193187598(+) TCTTAC/TTCTTT 1 -- ds50010--------
    --193187633(+) TTCTTC/GTAGAC 1 -- ds50010--------
    --193187652(+) GAAAAC/TAAGCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PTGS2 (186640923 - 186649559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PTGS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv413n71CNV Loss21882294
    nsv470750CNV Loss18288195
    dgv412n71CNV Loss21882294
    dgv414n71CNV Loss21882294
    nsv872590CNV Gain21882294

    Human Gene Mutation Database (HGMD): PTGS2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGS2
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600262    OMIM disorders: --

    20/328 diseases for PTGS2 (see all 328):    About MalaCards
    bile duct cysts    acute generalized exanthematous pustulosis    protoplasmic astrocytoma    teratoma with malignant transformation
    malignant mesenchymal tumor    uterine carcinosarcoma    adiponectin deficiency    bursitis
    bartter syndrome, type 2    small bowel adenocarcinoma    asthma and nasal polyps    esophagus adenocarcinoma
    atrophy of prostate    hemophilic arthropathy    bowenoid papulosis    familial adenomatous polyposis
    juvenile polyposis syndrome    colonic disease    intestinal neoplasm    cystoid macular edema

    20/22 diseases from the University of Copenhagen DISEASES database for PTGS2 (see all 22):
    Colorectal cancer     Arthritis     Carcinoma     Vascular disease
    Familial adenomatous polyposis     Gastrointestinal system disease     Adenoma     Lung cancer
    Pain agnosia     Breast cancer     Brain disease     Esophageal cancer
    Myocardial infarction     Prostate cancer     Skin cancer     Alzheimer's disease
    Urinary bladder cancer     Kidney disease     Endometriosis     Pancreatic cancer

    PTGS2 for disorders           About GeneDecksing

    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for PTGS2 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 82.3 1159 16580899 (5), 11437671 (4), 10414396 (4), 12669881 (4) (see all 99)
    colon cancer 78.8 585 19437564 (7), 12432918 (6), 20046424 (5), 18320325 (5) (see all 99)
    osteoarthritis 78.6 261 15974939 (4), 10560596 (3), 19602530 (3), 19807303 (3) (see all 99)
    tumors 76.5 3567 15200266 (8), 20192574 (8), 19329856 (7), 16139560 (7) (see all 99)
    colorectal cancer 76.2 748 19671325 (9), 16324362 (7), 16551850 (7), 19132985 (6) (see all 99)
    gastrointestinal complications 75.5 50 15475342 (3), 19947799 (2), 15190384 (2), 17552414 (2) (see all 33)
    cancer 75 1766 16124396 (6), 12692419 (6), 17428102 (5), 16007171 (5) (see all 99)
    familial adenomatous polyposis 72.3 128 14581346 (3), 10874062 (3), 16622748 (2), 11495083 (2) (see all 86)
    gastrointestinal ulcers 71.7 19 17611980 (1), 12208114 (1), 18356636 (1), 11961974 (1) (see all 14)
    rheumatoid arthritis 69.3 196 15974939 (3), 18261308 (3), 11087881 (2), 15775145 (2) (see all 99)

    Genetic Association Database (GAD): PTGS2
    Human Genome Epidemiology (HuGE) Navigator: PTGS2 (284 documents)

    Export disorders for PTGS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGS2 gene, integrated from 9 sources (see all 6683) (see top 10):
    (articles sorted by number of sources associating them with PTGS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. (PubMed id 17181859)1, 4, 7, 9 Shen J....Santella R.M. (2006)
    2. Human cyclooxygenase-2 cDNA. (PubMed id 1380156)1, 2, 3 Hla T. and Neilson K. (1992)
    3. No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. (PubMed id 19437564)1, 4, 9 Thompson C.L....Li L. (2009)
    4. COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. (PubMed id 17609663)1, 4, 9 Cheng I....Witte J.S. (2007)
    5. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. (PubMed id 19327107)1, 4, 9 Xie X....Liu F. (2009)
    6. Cyclooxygenase-2 polymorphisms, aspirin treatment, an d risk for colorectal adenoma recurrence--data from a randomized clinical trial . (PubMed id 19755647)1, 4, 9 Barry E.L....Baron J.A. (2009)
    7. The COX-2 promoter polymorphism -765 G>C is associated with early-onset, conventional and stump gastric cancers. (PubMed id 18311113)1, 4, 9 Sitarz R....Milne A.N. (2008)
    8. COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population. (PubMed id 18214026)1, 4, 9 Hou L....Chow W.H. (2007)
    9. Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. (PubMed id 17479405)1, 4, 9 Gao J....Shen H.B. (2007)
    10. The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production. (PubMed id 17178263)1, 4, 9 Skarke C....Lotsch J. (2006)
    11. Characterization of the human gene (PTGS2) encoding prostaglandin- endoperoxide synthase 2. (PubMed id 8181472)1, 2, 9 Kosaka T.... Tanabe T. (1994)
    12. PTGS2 and IL6 genetic variation and risk of breast an d prostate cancer: results from the Breast and Prostate Cancer Cohort Consortiu m (BPC3). (PubMed id 19965896)1, 4, 9 Dossus L....Cox D.G. (2010)
    13. Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans. (PubMed id 19031967)1, 4, 9 Ashktorab H....Ali I.U. (2008)
    14. Relationship between cyclooxygenase 8473T>C polymorphism and the risk of lung cancer: a case-control study. (PubMed id 16542464)1, 4, 9 Park J.M....Park J.Y. (2006)
    15. Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. (PubMed id 15173859)1, 4, 9 Cox D.G....Moreno V. (2004)
    16. -765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies. (PubMed id 19669667)1, 4, 9 Zhu W....Liu P. (2010)
    17. Role of cyclooxygenase-2 and 5-lipoxygenase polymorph isms in Alzheimer's disease in a population from northern Italy: implication fo r pharmacogenomics. (PubMed id 20110601)1, 4, 9 ListA- F....Candore G. (2010)
    18. Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. (PubMed id 19422084)1, 4, 9 Zhao D....Lin D. (2009)
    19. COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. (PubMed id 18974063)1, 4, 9 Fernandez P....Heyns C.F. (2008)
    20. Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. (PubMed id 17640058)1, 4, 9 Hubner R.A....Houlston R.S. (2007)
    21. COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States). (PubMed id 16489533)1, 4, 9 Sansbury L.B....Sandler R.S. (2006)
    22. A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. (PubMed id 15777967)1, 4, 9 Hu Z....Shen H. (2005)
    23. COX-2 gene promoter haplotypes and prostate cancer risk. (PubMed id 14754878)1, 4, 9 Panguluri R.C....Kittles R.A. (2004)
    24. Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer. (PubMed id 20332326)1, 4, 9 Bi N....Wang L. (2010)
    25. No association between the PPARG gene and schizophren ia in a British population. (PubMed id 19560328)1, 4, 9 Mathur A....Wei J. (2009)
    26. Polymorphism in COX-2 modifies the inverse associatio n between Helicobacter pylori seropositivity and esophageal squamous cell carci noma risk in Taiwan: a case control study. (PubMed id 19463183)1, 4, 9 Hu H.M....Wu D.C. (2009)
    27. COX-2 polymorphisms in patients with familial adenoma tous polyposis. (PubMed id 19544971)1, 4, 9 Peters W.H....Nagengast F.M. (2009)
    28. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PubMed id 19276290)1, 4, 9 Abraham J.E....Pharoah P.D. (2009)
    29. COX-2 polymorphisms -765G-->C and -1195A-->G an d colorectal cancer risk. (PubMed id 19777615)1, 4, 9 Hoff J.H....Peters W.H. (2009)
    30. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. (PubMed id 19318492)1, 4, 9 Fradet V....Witte J.S. (2009)
    31. Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: the Self Defense Forces Health Study. (PubMed id 18167131)1, 4, 9 Ueda N....Kono S. (2008)
    32. Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. (PubMed id 18349295)1, 4, 9 Ferguson H.R....Hardie L.J. (2008)
    33. Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy. (PubMed id 18825488)1, 4, 9 Achyut B.R....Mittal B. (2008)
    34. Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese. (PubMed id 17234302)1, 4, 9 Ma S.L....Lam L.C. (2008)
    35. Cyclooxygenase-2 polymorphisms and risk of rheumatoid arthritis in Koreans. (PubMed id 18381795)1, 4, 9 Yun H.R....Bae S.C. (2008)
    36. Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. (PubMed id 17999989)1, 4, 9 Danforth K.N....Hsing A.W. (2008)
    37. [Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer] (PubMed id 19062735)1, 4, 9 Xu D.K....Lin D.X. (2008)
    38. Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index. (PubMed id 18350611)1, 4, 9 Xing L.L....Zhang X. (2008)
    39. MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer. (PubMed id 17851225)1, 4, 9 Pan J.H....Yu Q.Z. (2008)
    40. Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population. (PubMed id 17404026)1, 4, 9 Lee T.S....Song Y.S. (2007)
    41. Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism. (PubMed id 17066444)1, 4, 9 Hedelin M....Balter K.A. (2007)
    42. Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis. (PubMed id 17322116)1, 7, 9 Weinheimer E.M....Trappe T.A. (2007)
    43. Genetic variation in the COX-2 gene and the association with prostate cancer risk. (PubMed id 16506214)1, 4, 9 Shahedi K....Xu J. (2006)
    44. The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease. (PubMed id 16309832)1, 4, 9 Abdullah L....Mullan M. (2006)
    45. Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs. (PubMed id 16678543)1, 4, 9 Lee Y.S....Dionne R.A. (2006)
    46. Cyclooxygenase-2 genotype and rheumatoid arthritis. (PubMed id 16821264)1, 4, 9 Lee K.H....Bae S.C. (2006)
    47. Polymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancer. (PubMed id 15596291)1, 4, 9 Kang S....Lee H.P. (2005)
    48. Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption. (PubMed id 15550453)1, 4, 9 Siezen C.L....Kampman E. (2005)
    49. Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease. (PubMed id 16273614)1, 4, 9 Cox D.G....Canzian F. (2005)
    50. Functional promoter polymorphism of cyclooxygenase-2 modulates the inflammatory response in stable coronary heart disease. (PubMed id 20332714)1, 4, 9 Sanak M....Szczeklik A. (2010)
    51. Functional rs20417 SNP (-765G>C) of cyclooxygenase -2 gene does not predict the risk of recurrence of ischemic events in coronary patients: results of a 7-year prospective study. (PubMed id 20299798)1, 4, 9 Montali A....Arca M. (2010)
    52. Associations between COX-2 polymorphisms, blood chole sterol and risk of acute coronary syndrome. (PubMed id 19748095)1, 4, 9 Vogel U....Overvad K. (2010)
    53. Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population. (PubMed id 18819034)1, 4, 9 Ostergaard M....Andersen V. (2009)
    54. Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions. (PubMed id 19197984)1, 4, 9 Pu X....Wu X. (2009)
    55. Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma. (PubMed id 19205707)1, 4, 9 Gong Z....Hebert J.R. (2009)
    56. Cyclooxygenase-2 polymorphisms and the risk of esopha geal adeno- or squamous cell carcinoma. (PubMed id 19630103)1, 4, 9 Kristinsson J.O....Peters W.H. (2009)
    57. Host single nucleotide polymorphisms of MMP-9 -1562/T IMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. (PubMed id 19889076)1, 4, 9 Hung K.H....Sheu B.S. (2009)
    58. COX-2 polymorphisms and the risk for head and neck cancer in white patients. (PubMed id 19280666)1, 4, 9 Peters W.H....Manni J.J. (2009)
    59. Effect of COX2 -765G>C and c.3618A>G polymorphi sms on the risk and survival of sporadic colorectal cancer. (PubMed id 19468846)1, 4, 9 Iglesias D....FernA!ndez-Peralta A.M. (2009)
    60. Prognostic Significance and Clinicopathological Assoc iations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. (PubMed id 20016751)1, 4, 9 Grimminger P.P....Brabender J. (2009)
    61. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4, 9 Lemaitre R.N....Psaty B.M. (2008)
    62. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PubMed id 18038187)1, 4, 9 Hoeft B....Nieters A. (2008)
    63. A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis. (PubMed id 18930197)1, 4, 9 Juo S.H....Tsai E.M. (2008)
    64. [Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China] (PubMed id 19040046)1, 4, 9 Xie X....Liu F. (2008)
    65. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. (PubMed id 18471798)1, 4, 9 Valdes A.M....Spector T.D. (2008)
    66. Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study. (PubMed id 17350020)1, 4, 9 Kohsaka S....Boerwinkle E. (2008)
    67. Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. (PubMed id 18768181)1, 4, 9 Rudock M.E....Bowden D.W. (2008)
    68. A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. (PubMed id 17214885)1, 4, 9 Cox D.G....Hunter D.J. (2007)
    69. CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. (PubMed id 17924829)1, 4, 9 Kim S.H....Park H.S. (2007)
    70. Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. (PubMed id 17151091)1, 4, 9 Tan W....Lin D. (2007)
    71. n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells. (PubMed id 17459764)1, 7, 9 Chene G....Pipy B. (2007)
    72. Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (PubMed id 17460548)1, 4, 9 Guo Y....Lin D. (2007)
    73. Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. (PubMed id 17175104)1, 7, 9 Lee Y.S....Dionne R.A. (2007)
    74. Cyclooxygenase-2 polymorphisms in Parkinson's disease. (PubMed id 17171651)1, 4, 9 Hakansson A....Nissbrandt H. (2007)
    75. Glycosylation regulates turnover of cyclooxygenase-2. (PubMed id 17113084)1, 2, 9 Sevigny M.B....Hughes-Fulford M. (2006)
    76. The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia. (PubMed id 16479190)1, 4, 9 Colaizzo D....Toni D. (2006)
    77. Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta. (PubMed id 16344721)1, 4, 9 Siezen C.L....Kampman E. (2006)
    78. Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. (PubMed id 16879213)1, 4, 9 Hegener H.H....Zee R.Y. (2006)
    79. Inflammation-related gene polymorphisms and colorectal adenoma. (PubMed id 16775170)1, 4, 9 Gunter M.J....Rothman N. (2006)
    80. Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors. (PubMed id 16458279)1, 4, 9 Orbe J....Paramo J.A. (2006)
    81. PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. (PubMed id 15767339)1, 4, 9 Ulrich C.M....Bigler J. (2005)
    82. Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism. (PubMed id 15930344)1, 4, 9 Brosens L.A....Goggins M. (2005)
    83. Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (PubMed id 14749922)1, 4, 9 Choi J.H....Shin H.D. (2004)
    84. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. (PubMed id 15138244)1, 4, 9 Cipollone F....Mezzetti A. (2004)
    85. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. (PubMed id 14604894)1, 4, 9 Campa D....Canzian F. (2004)
    86. Testing for colon neoplasia susceptibility variants at the human COX2 locus. (PubMed id 11309440)1, 4, 9 Wiesner G.L....Markowitz S.D. (2001)
    87. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. (PubMed id 8473346)1, 2, 9 Jones D.A....Prescott S.M. (1993)
    88. Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. (PubMed id 21042835)1, 4 AkkA+z H....Ulger Y. (2011)
    89. Hodgkin disease risk: Role of genetic polymorphisms a nd gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (2011)
    90. Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for urinary bladder cancer in North India. (PubMed id 20627335)1, 4 Gangwar R....Mittal R.D. (2011)
    91. Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan. (PubMed id 21273602)1, 4 Wu H.C....Bau D.T. (2011)
    92. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    93. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    94. A pilot study on prostate cancer risk and pro-inflamm atory genotypes: pathophysiology and therapeutic implications. (PubMed id 20388081)1, 4 Balistreri C.R....Candore G. (2010)
    95. Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)1, 4 Potter C....Wilson A.G. (2010)
    96. Common Genetic Variation, Residential Proximity to Tr affic Exposure, and Left Ventricular Mass: The Multi-Ethnic Study of Atheroscle rosis. (PubMed id 20308035)1, 4 Van Hee V.C....Kaufman J.D. (2010)
    97. Polymorphisms in regulatory regions of cyclooxygenase -2 gene and breast cancer risk in Brazilians: a case-control study. (PubMed id 21059239)1, 4 Piranda D.N....Vianna-Jorge R. (2010)
    98. Functional polymorphism of cyclooxygenase-2 gene (G-7 65C) in depressive patients. (PubMed id 20588070)1, 4 GaA8ecki P....Szemraj J. (2010)
    99. Polymorphisms in inflammatory genes, plasma antioxida nts, and prostate cancer risk. (PubMed id 20431935)1, 4 Zhang J....Kadlubar F.F. (2010)
    100. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    101. Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis. (PubMed id 20594217)1, 4 Dong J....Shen H. (2010)
    102. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    103. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    104. Association study of cyclooxygenase 2 single nucleoti de polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. (PubMed id 20944149)1, 4 Wang C.H....Bau D.T. (2010)
    105. The -765C allele of the cyclooxygenase-2 gene as a po tential risk factor of colorectal cancer: a meta-analysis. (PubMed id 20808059)1, 4 Cao H....Li S.L. (2010)
    106. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    107. Genetic variants in inflammation-related genes are as sociated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1, 4 Hildebrandt M.A....Wu X. (2010)
    108. Pooled analysis of the association of PTGS2 rs5275 po lymorphism and NSAID use with invasive ovarian carcinoma risk. (PubMed id 20559705)1, 4 Lurie G....Goodman M.T. (2010)
    109. Cyclooxygenase-2 gene polymorphisms and risk of cervi cal cancer in a North Indian population. (PubMed id 20686383)1, 4 Pandey S....Mittal B. (2010)
    110. Association of -765G>C polymorphism of the COX-2 g ene with recurrent embryo implantation failure in Southern Chilean women. (PubMed id 20599859)1, 4 Salazar L.A....GuzmA!n N. (2010)
    111. Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. (PubMed id 20538124)1, 4 St Germaine C.G....Brophy J.M. (2010)
    112. Cox-2 and IL-10 polymorphisms and association with sq uamous cell carcinoma of the head and neck in a Korean sample. (PubMed id 20592893)1, 4 Jeong S.W....Shin H.D. (2010)
    113. Prostaglandin-endoperoxide synthase genes COX1 and CO X2 - novel modifiers of disease severity in cystic fibrosis patients. (PubMed id 20720307)1, 4 Czerska K....Bal J. (2010)
    114. Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. (PubMed id 20034614)1, 4 Su K.P....Pariante C.M. (2010)
    115. Analysis of common germline polymorphisms as prognost ic factors in patients with lymph node-positive breast cancer. (PubMed id 20204402)1, 4 Knechtel G....Langsenlehner U. (2010)
    116. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    117. TNF superfamily gene polymorphism as prognostic facto r in early breast cancer. (PubMed id 19890662)1, 4 Jung J.H....Park H.Y. (2010)
    118. COX-2 polymorphisms and colorectal cancer risk: a str ategy for chemoprevention. (PubMed id 20075740)1, 4 Pereira C....Dinis-Ribeiro M. (2010)
    119. Influence of cyclooxygenase-2 (COX-2) gene promoter p olymorphism at position -765 on skin cancer after renal transplantation. (PubMed id 20445548)1, 4 Aubin F....Ducloux D. (2010)
    120. A haplotype of cyclooxygenase-2 gene is associated wi th idiopathic pulmonary fibrosis. (PubMed id 21319594)1, 4 Xaubet A....Picado C. (2010)
    121. Study on the association of COX-2 genetic polymorphis ms with risk of gastric cancer in high incidence Hexi area of Gansu province in China. (PubMed id 20364406)1, 4 Ke-Xiang Z....Tao L. (2010)
    122. Association of haplotypes of inflammation-related gen es with gastric preneoplastic lesions in African Americans and Caucasians. (PubMed id 20473875)1, 4 Zabaleta J....Ochoa A.C. (2010)
    123. Cetuximab as second-line therapy in patients with met astatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S 0415). (PubMed id 20631636)1, 4 Gold P.J....Blanke C.D. (2010)
    124. Association study of interferon-I^, cytosolic phosphol ipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease. (PubMed id 20808133)1, 4 FehAcr A....Janka Z. (2010)
    125. Use of aspirin and other nonsteroidal antiinflammator y medications in relation to prostate cancer risk. (PubMed id 20688905)1, 4 Salinas C.A....Stanford J.L. (2010)
    126. COX-2 is associated with periodontitis in Europeans. (PubMed id 20177132)1, 4 Schaefer A.S....Schreiber S. (2010)
    127. Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients. (PubMed id 20530427)1, 4 Liu C.J....Bau D.T. (2010)
    128. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    129. Toll-like receptor signaling pathway variants and pro state cancer mortality. (PubMed id 19505919)1, 4 Stark J.R....Kraft P. (2009)
    130. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    131. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    132. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    133. Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts. (PubMed id 19056642)1, 4 Corella D....Estruch R. (2009)
    134. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of co lorectal cancer in a Danish prospective case-cohort study. (PubMed id 19930591)1, 4 Andersen V....Vogel U. (2009)
    135. Role of inflammation gene polymorphisms on pain sever ity in lung cancer patients. (PubMed id 19773451)1, 4 Reyes-Gibby C.C....Shete S. (2009)
    136. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. (PubMed id 19661089)1, 4 Hussain S.K....Zhang Z.F. (2009)
    137. G-765C COX-2 gene promoter polymorphism and risk of a therosclerosis after kidney transplantation. (PubMed id 19920789)1, 4 Courivaud C....Thervet E. (2009)
    138. Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. (PubMed id 19219602)1, 4 Kim J.G....Jun S.H. (2009)
    139. Cyclooxygenase-2 polymorphisms confer susceptibility to sarcoidosis but are not related to prognosis. (PubMed id 19042116)1, 4 Lopez-Campos J.L....Montes-Worboys A. (2009)
    140. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (2009)
    141. Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available? (PubMed id 19060633)1, 4 Pereira C....Dinis-Ribeiro M.J. (2009)
    142. The influence of COX-2 single nucleotide polymorphism s on abdominal aortic aneurysm development and the associated inflammation. (PubMed id 19625268)1, 4 Badger S.A....Hughes A.E. (2009)
    143. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (2009)
    144. Cyclooxygenase-2 (COX-2) G-765C is a protective facto r for coronary artery disease but not for ischemic stroke: a meta-analysis. (PubMed id 19631939)1, 4 Li W....Hui R. (2009)
    145. Influence of a type 2 diabetes associated prostaglandin E synthase 2 polymorphism on blood prostaglandin E2 levels. (PubMed id 19268562)1, 4 Boomgaarden I....DAPring F. (2009)
    146. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    147. [Genetic polymorphisms in STK15 and MMP-2 associated susceptibility to esophageal cancer in Mongolian population] (PubMed id 19954064)1, 4 Chen X.B....Tan W. (2009)
    148. Current evidence on the relationship between polymorp hisms in the COX-2 gene and breast cancer risk: a meta-analysis. (PubMed id 20033767)1, 4 Yu K.D....Shao Z.M. (2009)
    149. Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. (PubMed id 19428370)1, 4 Upadhyay R....Mittal B. (2009)
    150. Enhanced sensitivity of celecoxib in human glioblasto ma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. (PubMed id 19706164)1, 4 Kang K.B....Wong M.C. (2009)
    151. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)
    152. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    153. Functional polymorphisms of the cyclooxygenase (PTGS2 ) gene and risk for gallbladder cancer in a North Indian population. (PubMed id 19455278)1, 4 Srivastava K....Mittal B. (2009)
    154. Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma. (PubMed id 19223558)1, 4 Chang E.T....Mueller N.E. (2009)
    155. The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey. (PubMed id 19820421)1, 4 Ozhan G....Alpertunga B. (2009)
    156. PTGS2-899G>C and prostate cancer risk: a populatio n-based nested case-control study (ProtecT) and a systematic review with meta-a nalysis. (PubMed id 19488068)1, 4 Murad A....Martin R.M. (2009)
    157. Cyclooxygenase-2 Gly587Arg variant is associated with differential enzymatic activity and risk of esophageal squamous-cell carcinoma. (PubMed id 19347867)1, 4 Zhao D....Lin D. (2009)
    158. A gene-based risk score for lung cancer susceptibilit y in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (2009)
    159. Relation of genetic polymorphisms in the cytochrome P 450 gene with clopidogrel resistance after drug-eluting stent implantation in K oreans. (PubMed id 19576320)1, 4 Lee J.M....Jang Y. (2009)
    160. The genomic basis of cerebral palsy: a HuGE systematic literature review. (PubMed id 19238444)1, 4 O'Callaghan M.E....Dekker G. (2009)
    161. A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer. (PubMed id 19138835)1, 4 Li F....Li J. (2009)
    162. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    163. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (2009)
    164. Influence of cyclooxygenase-2 (COX-2) gene promoter p olymorphism -765 on graft loss after renal transplantation. (PubMed id 19788502)1, 4 Courivaud C....Ducloux D. (2009)
    165. Common single nucleotide polymorphisms in cyclooxygenase-2 and risk of severe chronic periodontitis in a Chinese population. (PubMed id 19236532)1, 4 Xie C.J....Zhang J.C. (2009)
    166. Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. (PubMed id 19047118)1, 4 Lurje G....Lenz H.J. (2008)
    167. The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing Auto-SCT. (PubMed id 18997828)1, 4 Vangsted A.J....Vogel U. (2008)
    168. Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease. (PubMed id 18989535)1, 4 Szczeklik W....Szczeklik A. (2008)
    169. Cyclo-Oxygenase-2 -765G > C Promoter Variants Are Associated with Lower Carotid Plaque Echogenicity in Japanese. (PubMed id 19033684)1, 4 Furukado S....Kitagawa K. (2008)
    170. Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions. (PubMed id 18287876)1, 4 Canzian F....Kato I. (2008)
    171. Association of COX2 functional polymorphisms and the risk of vitiligo in Chinese populations. (PubMed id 19004621)1, 4 Li M....Gao T. (2008)
    172. Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery. (PubMed id 18771989)1, 4 Skupski D.W....Witkin S.S. (2008)
    173. COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men: the Helsinki sudden death study. (PubMed id 18385811)1, 4 Huuskonen K.H....Nikkari S.T. (2008)
    174. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. (PubMed id 18992148)1, 4 KA1ry S....BAczieau S. (2008)
    175. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (2008)
    176. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)
    177. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    178. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    179. Association between PTGS2 polymorphism and autism spectrum disorders in Korean trios. (PubMed id 18579107)1, 4 Yoo H.J....Kim S.A. (2008)
    180. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PubMed id 18691306)1, 4 Chan I.H....Lam C.W. (2008)
    181. Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: a study from northern India. (PubMed id 18330937)1, 4 Saxena A....Husain N. (2008)
    182. Cyclooxygenase-2 gene polymorphisms in an Australian population: association of the -1195G > A promoter polymorphism with mild asthma. (PubMed id 18489027)1, 4 Shi J....Thompson P.J. (2008)
    183. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (2008)
    184. Polymorphisms of COX-2 -765G>C and p53 codon 72 and risks of oral squamous cell carcinoma in a Taiwan population. (PubMed id 18234542)1, 4 Lin Y.C....Chen C.H. (2008)
    185. Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. (PubMed id 18164040)1, 4 Vogel U....Tjonneland A. (2008)
    186. Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype. (PubMed id 19075598)1, 4 Siemes C....Stricker B.H. (2008)
    187. Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 17495879)1, 4 Lee C.R....Zeldin D.C. (2008)
    188. Association of the 3050G>C polymorphism in the cyclooxygenase 2 gene with systemic sarcoidosis. (PubMed id 18514098)1, 4 Lopez-Campos J.L....Montes-Worboys A. (2008)
    189. Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. (PubMed id 18173398)1, 4 Ho Y.P....Tsai C.C. (2008)
    190. Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. (PubMed id 18381966)1, 4 Yang H....Wu X. (2008)
    191. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    192. Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. (PubMed id 18922923)1, 4 Chiang S.L....Ko Y.C. (2008)
    193. COX2 and p53 risk-alleles coexist in COPD. (PubMed id 18692035)1, 4 Arif E....Pasha M.A. (2008)
    194. Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. (PubMed id 17578436)1, 4 Lira M.G....Turco A. (2007)
    195. Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes. (PubMed id 17307204)1, 4 Vogel U....Tjonneland A. (2007)
    196. A multigenic approach to predict breast cancer risk. (PubMed id 17058024)1, 4 Gerger A....Krippl P. (2007)
    197. Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant. (PubMed id 16905570)1, 4 Harding D.R....Montgomery H.E. (2007)
    198. COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma. (PubMed id 17581270)1, 4 Moons L.M....Kusters J.G. (2007)
    199. Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. (PubMed id 17356794)1, 4 Campa D....Canzian F. (2007)
    200. Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. (PubMed id 17573729)1, 4 Chan I.H....Lam C.W. (2007)
    201. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    202. A fetal cyclooxygenase-2 gene polymorphism is associated with placental malperfusion. (PubMed id 17581413)1, 4 Polydorides A.D....Baergen R.N. (2007)
    203. An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk. (PubMed id 18006935)1, 4 Schwartzbaum J.A....Feychting M. (2007)
    204. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (PubMed id 17355643)1, 4 Huang H.Y....Helzlsouer K.J. (2007)
    205. COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk. (PubMed id 17373929)1, 4 Mazzola S....Pignatti P.F. (2007)
    206. PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma. (PubMed id 17968676)1, 4 Ben Nasr H....Chouchane L. (2007)
    207. Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes. (PubMed id 16959787)1, 4 Vogel U....Tjonneland A. (2007)
    208. Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. (PubMed id 17560944)1, 7 Chae S.W....Choi H.J. (2007)
    209. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    210. Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population. (PubMed id 16762620)1, 4 Liu F....You W. (2006)
    211. The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk. (PubMed id 16489098)1, 4 Langsenlehner U....Krippl P. (2006)
    212. Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. (PubMed id 16702043)1, 4 Kranzhofer R. and Ruef J. (2006)
    213. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab. (PubMed id 16788380)1, 4 Zhang W....Lenz H.J. (2006)
    214. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PubMed id 17202846)1, 4 Park B.L....Shin H.D. (2006)
    215. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. (PubMed id 16453284)1, 4 Valdes A.M....Spector T.D. (2006)
    216. Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients. (PubMed id 16407418)1, 4 de las Penas R....Rosell R. (2006)
    217. -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia. (PubMed id 17006983)1, 4 Pereira C....Dinis-Ribeiro M. (2006)
    218. [Genetic polymorphisms in the promoter region of cyclooxygenase-2 and their association with risk of gastric cancer] (PubMed id 16733888)1, 4 Zhang X.M....Lin D.X. (2006)
    219. Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. (PubMed id 16361272)1, 4 Sakoda L.C....Hsing A.W. (2006)
    220. Functional prostaglandin-endoperoxide synthase 2 polymorphism predicts poor outcome in sarcoidosis. (PubMed id 16840740)1, 4 Hill M.R....Laurent G.J. (2006)
    221. Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans. (PubMed id 16871410)1, 4 Her M.Y....Bae S.C. (2006)
    222. A genetic polymorphism in prostaglandin synthase 2 (8473, T-->C) and the risk of lung cancer. (PubMed id 15882925)1, 4 Sorensen M....Raaschou-Nielsen O. (2005)
    223. Polymorphisms associated with asthma are inversely related to glioblastoma multiforme. (PubMed id 16024651)1, 4 Schwartzbaum J....Feychting M. (2005)
    224. Inducible nitric oxide synthase binds, S-nitrosylates , and activates cyclooxygenase-2. (PubMed id 16373578)1, 2 Kim S.F....Snyder S.H. (2005)
    225. Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. (PubMed id 16205694)1, 4 Ali I.U....Greenwald P. (2005)
    226. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. (PubMed id 16083713)1, 4 Zhang X....Lin D. (2005)
    227. Cyclooxygenase-1 haplotype modulates platelet response to aspirin. (PubMed id 16150050)1, 4 Maree A.O....Fitzgerald D.J. (2005)
    228. A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. (PubMed id 16181776)1, 4 Wei J. and Hemmings G.P. (2005)
    229. Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. (PubMed id 15150618)1, 4 Koh W.P....Yu M.C. (2004)
    230. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    231. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)1, 4 Iwai N....Shioji K. (2004)
    232. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 2 Goodman J.E.... Harris C.C. (2004)
    233. A functional polymorphism in the promoter region of the cyclooxygenase-2 gene is not associated with asthma and atopy in an Australian population. (PubMed id 15544595)1, 4 Shi J....Kedda M.A. (2004)
    234. Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians. (PubMed id 12920574)1, 4 Konheim Y.L. and Wolford J.K. (2003)
    235. Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. (PubMed id 12433707)1, 4 Lin H.J....Smith W.L. (2002)
    236. Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients. (PubMed id 12164325)1, 4 Hamajima N....Tajima K. (2002)
    237. Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. (PubMed id 12377741)1, 4 Papafili A....Laurent G.J. (2002)
    238. Genotype Frequencies of Cyclooxygenease 2 (COX2) Rare Polymorphisms for Japanese with and without Colorectal Cancer. (PubMed id 12718655)1, 4 Hamajima N....Tajima K. (2001)
    239. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. (PubMed id 7947975)1, 2 Barnett J.... Freire J. (1994)
    240. Structure of the human cyclo-oxygenase-2 gene. (PubMed id 7945196)1, 2 Appleby S.B.... Hla T. (1994)
    241. Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. (PubMed id 12209745)1, 9 Kim Y.B....Kim B.S. (2002)
    242. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. (PubMed id 11959891)1, 9 Song X....Chen C.S. (2002)
    243. Cyclooxygenase-2 (COX-2) negatively regulates express ion of epidermal growth factor receptor and causes resistance to gefitinib in C OX-2-overexpressing cancer cells. (PubMed id 19671676)1, 9 Kim Y.M....Pyo H. (2009)
    244. Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. (PubMed id 16632868)1, 9 Tong M....Tai H.H. (2006)
    245. Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. (PubMed id 11891209)1, 9 Niki T....Hirohashi S. (2002)
    246. [VEGF, COX-2 and MVD in lesions of patients with condyloma acuminatum] (PubMed id 19462903)1, 9 Liu T. and Zhang H.H. (2009)
    247. [Effect of hypoxia and IL-1beta on COX-2 expression and PGE2 release in human nasal epithelia] (PubMed id 19452719)1, 9 Wang Z....Liu Y. (2009)
    248. [Effect of lipopolysaccharide on cyclooxygenase-2 exp ression and prostaglandin E2 release in human nasal epithelia] (PubMed id 18727513)1, 9 Wang Z....Yang Q. (2008)
    249. Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. (PubMed id 18230181)1, 9 Kawasaki T....Ogino S. (2008)
    250. Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. (PubMed id 18671849)1, 9 Zhu Y.M....Woll P.J. (2008)
    251. Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. (PubMed id 15921850)1, 9 Cressey R....Leartprasertsuke N. (2006)
    252. Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. (PubMed id 15608668)1, 9 Corcoran C.A....Sheikh M.S. (2005)
    253. Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. (PubMed id 15968728)1, 9 Zhi Y.H....Guo R.X. (2005)
    254. Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. (PubMed id 15156159)1, 9 Murata H....Hori M. (2004)
    255. Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. (PubMed id 12767510)1, 9 Yu H.G....Schmitz F. (2003)
    256. Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma. (PubMed id 14532971)1, 9 Leung W.K....Sung J.J. (2003)
    257. Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. (PubMed id 11078056)7, 9 Fosslien E. (2000)
    258. Expression and prognostic significance of Cox-2 and p -53 in Hodgkin lymphomas: a retrospective study. (PubMed id 20346139)1, 9 Barisik N.O....Tecimer T. (2010)
    259. Cyclooxygenase-2 expression in non-Hodgkin's lymphomas. (PubMed id 17325901)1, 9 Paydas S....Seydaoglu G. (2007)
    260. Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner. (PubMed id 17635918)1, 9 Jang B.C....Suh S.I. (2007)
    261. Site-specific proteolysis of cyclooxygenase-2: a putative step in inflammatory prostaglandin E(2) biosynthesis. (PubMed id 17177291)1, 9 Mancini A....Di Battista J.A. (2007)
    262. Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. (PubMed id 16243808)1, 9 Mrena J....Haglund C. (2005)
    263. Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. (PubMed id 16083499)1, 9 Yoshida S....Adrian T.E. (2005)
    264. The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. (PubMed id 14566822)1, 9 Park S.W....Sung M.W. (2003)
    265. [Expression and function of cyclooxygenase-2 in endom etrial carcinoma] (PubMed id 20019776)1, 9 Chen J.Y. and Liao Q.P. (2009)
    266. Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. (PubMed id 18498876)1, 9 Singh B....Lucci A. (2008)
    267. The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. (PubMed id 18320325)1, 9 Zhang H....Wang S. (2008)
    268. Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma. (PubMed id 18705402)1, 9 Do S.I....Park Y.K. (2008)
    269. Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. (PubMed id 17341442)1, 9 Cao Z....Jiang B.H. (2007)
    270. The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. (PubMed id 17429597)1, 9 Neuss H....Dubiel W. (2007)
    271. EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. (PubMed id 18032824)1, 9 Konstantinopoulos P.A....Papavassiliou A.G. (2007)
    272. Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. (PubMed id 16551850)1, 9 Castells A....Pique J.M. (2006)
    273. Expression of cyclooxygenase isoforms in developing rat placenta, human term placenta, and BeWo human trophoblast model. (PubMed id 16323955)1, 9 Xu Y....Cook T.J. (2005)
    274. Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. (PubMed id 16044148)1, 9 Yang W.L....Xu X.X. (2005)
    275. Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. (PubMed id 15695237)1, 9 Nosho K....Imai K. (2005)
    276. Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. (PubMed id 15754118)1, 9 Sivula A....Turpeenniemi-Hujanen T. (2005)
    277. Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells. (PubMed id 15569819)1, 9 Michaelis U.R....Fleming I. (2005)
    278. Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. (PubMed id 15010822)1, 9 Cheng A.S....Sung J.J. (2004)
    279. Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas. (PubMed id 15569051)1, 9 Hemmerlein B....Heuser M. (2004)
    280. Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer. (PubMed id 15228443)1, 9 Witton C.J....Bartlett J.M. (2004)
    281. Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. (PubMed id 14760075)1, 9 Erkinheimo T.L....Ristimaki A. (2004)
    282. Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. (PubMed id 15231484)1, 9 Souza R.F....Spechler S.J. (2004)
    283. Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF. (PubMed id 12881220)1, 9 Wu G....Li J. (2003)
    284. Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. (PubMed id 12532441)1, 9 Xue Y.W....Fu S.B. (2003)
    285. Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. (PubMed id 12532440)1, 9 Guo X.L....Yuan Y. (2003)
    286. Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu expression in ovarian cancer. (PubMed id 11972392)1, 9 Ferrandina G....Scambia G. (2002)
    287. Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma. (PubMed id 19039588)1, 9 Johansson C.C....Kiessling R. (2009)
    288. Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. (PubMed id 18181047)1, 9 Tang H....Fan D. (2008)
    289. Coexpression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor: possible relations to pathological parameters and clinical behavior. (PubMed id 19260469)1, 9 Miao R....Li J. (2008)
    290. [Correlation of Helicobacter pylori infection with the expression of COX-2 and EGFR and VEGF in human gastric carcinoma] (PubMed id 19173907)1, 9 Xiao W.M....Xue Y. (2008)
    291. Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. (PubMed id 17332916)1, 9 Simeone A.M....Tari A.M. (2007)
    292. [Blood vessel multiply and significance of expression of Cox-2, VEGF in pterygium] (PubMed id 17444036)1, 9 Yan M....Wang F. (2007)
    293. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. (PubMed id 15222037)1, 9 Kasper H.U....Kern M.A. (2004)
    294. COX-2 status in relation to tumor microvessel density and VEGF expression: analysis in ovarian carcinoma patients with low versus high survival rates. (PubMed id 14719060)1, 9 Raspollini M.R....Taddei G.L. (2004)
    295. Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells. (PubMed id 15210717)1, 9 Kim S.Y....Min D.S. (2004)
    296. Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. (PubMed id 15222024)1, 9 Li H.L....Ma F.C. (2004)
    297. Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. (PubMed id 12883661)1, 9 Lim S.C....Do N.Y. (2003)
    298. Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. (PubMed id 12883688)1, 9 Lim S.C. (2003)
    299. Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. (PubMed id 12839952)1, 9 Liu W....Ellis L.M. (2003)
    300. Expression of cyclooxygenase-2 in eutopic endometrium and ovarian endometriotic tissue in women with severe endometriosis. (PubMed id 20068324)1, 9 Cho S....Lee B.S. (2010)
    301. Differential expression of cyclooxygenases in hypertr ophic scar and keloid tissues. (PubMed id 19769727)1, 9 Rossiello L....Rossiello R. (2009)
    302. Cyclooxygenase-2 mediated regulation of E-cadherin oc curs in conventional but not early-onset gastric cancer cell lines. (PubMed id 19940363)1, 9 Sitarz R....Milne A.N. (2009)
    303. Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors. (PubMed id 19845533)1, 9 TA1rkAPz H.K....Ozcan D. (2009)
    304. [The expressions of PPAR-gamma, COX-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis] (PubMed id 19627000)1, 9 Ni J....Xue S.L. (2009)
    305. Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associ ated with EBV infection. (PubMed id 19118057)1, 9 Park E.S....Kim K.M. (2009)
    306. Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. (PubMed id 18663571)1, 9 Lucci A....Cristofanilli M. (2009)
    307. Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis. (PubMed id 18053993)1, 9 Ceyhan S.T....Gunhan O. (2008)
    308. Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cells. (PubMed id 18212353)1, 9 Casciani V....Challis J.R. (2008)
    309. Prognostic value of COX-2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer. (PubMed id 19132985)1, 9 Zafirellis K....Zachaki A. (2008)
    310. COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells. (PubMed id 18093816)1, 9 Futagami S....Sakamoto C. (2008)
    311. Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. (PubMed id 17511025)1, 9 Yoshikawa R....Tsujimura T. (2007)
    312. Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction. (PubMed id 17868881)1, 9 Zidar N....Stajer D. (2007)
    313. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. (PubMed id 17693978)1, 9 Maes M....Bosmans E. (2007)
    314. YKL-40 in human lumbar herniated disc and its relationships with nitric oxide and cyclooxygenase-2. (PubMed id 17631744)1, 9 Pozzuoli A....Punzi L. (2007)
    315. Analysis of renal immunoexpression of cyclooxygenase-1 and cyclooxygenase-2 in lupus and nonlupus membranous glomerulopathy. (PubMed id 18459455)1, 9 Danilewicz M. and Wagrowska-Danilewicz M. (2007)
    316. Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma. (PubMed id 16169726)1, 9 Cho M.H....Min K.W. (2006)
    317. Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis. (PubMed id 16456945)1, 9 Chou Y.C....Yuan C.C. (2006)
    318. Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. (PubMed id 17192687)1, 9 Mohammad A.M....Eiman G. (2006)
    319. COX-2 overexpression increases motility and invasion of breast cancer cells. (PubMed id 15809733)1, 9 Singh B....Lucci A. (2005)
    320. Mechanism and clinical significance of cyclooxygenase-2 expression in gastric cancer. (PubMed id 15929174)1, 9 Wang B.C....Li D.G. (2005)
    321. Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa. (PubMed id 15720413)1, 9 Bhandari P....Patel P. (2005)
    322. Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. (PubMed id 14742690)7, 9 Mifflin R.C....Powell D.W. (2004)
    323. The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis. (PubMed id 15301234)1, 9 Studynkova J.T....Gay S. (2004)
    324. Expression of cyclooxygenase-2 and its correlation with clinicopathologic factors of ampulla of vater cancer. (PubMed id 12692419)1, 9 Kim H.J....Rhee J.C. (2003)
    325. PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells. (PubMed id 12754192)1, 9 Chambers L.S....Burgess J.K. (2003)
    326. Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis. (PubMed id 12970891)1, 9 Wu A.W....Xu G.W. (2003)
    327. [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma] (PubMed id 12667327)1, 9 Pang D....Xue Y. (2002)
    328. p38 MAPK plays a distinct role in sulforaphane-induce d up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells. (PubMed id 20204301)1, 9 Shan Y....Bao Y. (2010)
    329. Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. (PubMed id 19280060)1, 9 Guo X....Yu X. (2009)
    330. Cyclooxygenase-2 expression, Ki-67 labeling index, an d perifocal neovascularization in endometriotic lesions. (PubMed id 19917472)1, 9 Horn L.C....Leo C. (2009)
    331. COX-2 expression does not correlate with microvessel density in breast cancer. (PubMed id 19188749)1, 9 Thorat M.A....Badve S. (2009)
    332. Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. (PubMed id 18985541)1, 9 Bartchewsky W....Ribeiro M.L. (2009)
    333. [Expression of COX-2 and VEGF-C in papillary thyroid carcinoma and their relationship to cervical lymph metastases] (PubMed id 20120873)1, 9 Miao A....Cheng L. (2009)
    334. Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. (PubMed id 19244345)1, 9 Rodriguez D.A....Quest A.F. (2009)
    335. Cyclooxygenase-2 expression is associated with vascul ar endothelial growth factor-C and lymph node metastases in human prostate canc er. (PubMed id 19608016)1, 9 Di J.M....Ruan X.X. (2009)
    336. Up-regulation of cyclooxygenase-2 expression and pros taglandin E2 production in human endometriotic cells by macrophage migration in hibitory factor: involvement of novel kinase signaling pathways. (PubMed id 19299454)1, 9 Carli C....Akoum A. (2009)
    337. COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. (PubMed id 18753249)1, 9 Harrington L.S....Mitchell J.A. (2008)
    338. Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. (PubMed id 18373164)1, 9 Futagami S....Sakamoto C. (2008)
    339. Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells. (PubMed id 18565510)1, 9 Liou J.T....Lai J.H. (2008)
    340. Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. (PubMed id 18190720)1, 9 Zhang X.H....Chen S.Y. (2008)
    341. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. (PubMed id 18565574)1, 9 Hammes L.S....Cunha-Filho J.S. (2008)
    342. Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. (PubMed id 18334709)1, 9 Visscher D.W....Hartmann L.C. (2008)
    343. Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells. (PubMed id 17982644)1, 9 Chan M.W....Leung W.K. (2007)
    344. [Correlation of cyclooxygenase 2 with upstream mitoge n-activated protein kinase, nuclear factor kappa B signal transduction pathway in middle turbinate mucosa of chronic rhinosinusitis] (PubMed id 17702421)1, 9 Wang Z.L....Wei Y. (2007)
    345. Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells. (PubMed id 17868457)1, 9 Shelby B.D....Sullivan D.E. (2007)
    346. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. (PubMed id 16570043)1, 9 Timoshenko A.V....Lala P.K. (2006)
    347. A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells. (PubMed id 17156488)1, 9 Basu G.D....Mukherjee P. (2006)
    348. PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. (PubMed id 16215757)1, 9 Vandoros G.P....Papavassiliou A.G. (2006)
    349. Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. (PubMed id 16984258)1, 9 Zhang Q....Travers J.B. (2006)
    350. Contribution of inducible nitric oxide synthase and cyclooxygenase-2 to apoptosis induction in smooth chorion trophoblast cells of human fetal membrane tissues. (PubMed id 16442500)1, 9 Yuan B....Toyoda H. (2006)
    351. Increased cyclooxygenase-2 expression is associated with better clinical outcome in patients submitted to complete ablation for severe endometriosis. (PubMed id 15979990)1, 9 Fanfani F....Scambia G. (2005)
    352. Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression. (PubMed id 16101131)1, 9 Uefuji K....Mochizuki H. (2005)
    353. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. (PubMed id 15767259)1, 9 Kim H....LaMont J.T. (2005)
    354. Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. (PubMed id 15704107)1, 9 Yuan A....Yang P.C. (2005)
    355. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. (PubMed id 15655513)7, 9 Esser R....Marshall P.J. (2005)
    356. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. (PubMed id 15896711)1, 9 Hwang J.T....Park O.J. (2005)
    357. Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis. (PubMed id 16097070)1, 9 Yu J.R....Zheng S.S. (2005)
    358. Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. (PubMed id 15330183)1, 9 Ranger G.S....Mokbel K. (2004)
    359. COX-2 expression and tumor angiogenesis in colorectal cancer. (PubMed id 15285012)1, 9 Wu A.W....Xu G.W. (2004)
    360. [Research on relationships of gastric cancer with ser um trace elements, Helicobacter pylori and COX-2 in gastric tissue] (PubMed id 15022477)1, 9 Li Y....Zhou Y. (2004)
    361. Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells. (PubMed id 15331599)1, 9 Pawliczak R....Shelhamer J.H. (2004)
    362. Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets. (PubMed id 15471850)1, 9 Heitmeier M.R....Maziasz T.J. (2004)
    363. Reciprocal expression of peroxisome proliferator-activated receptor-gamma and cyclooxygenase-2 in human term parturition. (PubMed id 15042019)1, 9 Dunn-Albanese L.R....Kniss D.A. (2004)
    364. [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] (PubMed id 14989896)1, 9 Yu H.P....Xu S.Q. (2004)
    365. Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. (PubMed id 12957358)1, 9 Yu H.P....Li Y.Y. (2003)
    366. Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. (PubMed id 12800231)1, 9 Xiong B....Cheng F.L. (2003)
    367. Immunohistochemical analysis of cyclooxygenase-2 and vascular endothelial growth factor in pancreaticobiliary maljunction. (PubMed id 12579269)1, 9 Tsuchida A....Koyanagi Y. (2003)
    368. Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. (PubMed id 14607721)1, 9 Wu G.S....Zou S.Q. (2002)
    369. Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. (PubMed id 11957147)1, 9 Fujiwaki R....Miyazaki K. (2002)
    370. Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging. (PubMed id 12162677)1, 9 Maitra A....Wilentz R.E. (2002)
    371. Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. (PubMed id 11920515)1, 9 Niijima M....Saisho H. (2002)
    372. PPARgamma agonists inhibit angiogenesis by suppressin g PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. (PubMed id 20032081)1, 9 Scoditti E....De Caterina R. (2010)
    373. Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in ga stric mucosa with intestinal metaplasia or dysplasia. (PubMed id 20492336)1, 9 Liu D....Liu C. (2010)
    374. Overexpression of cyclooxygenase-2 in urothelial carcinoma in conjunction with tumor-associated-macrophage infiltration, hypoxia-inducible factor-1alpha expression, and tumor angiogenesis. (PubMed id 19245590)1, 9 Chen W.T....Chai C.Y. (2009)
    375. HGF/Met signalling promotes PGE(2) biogenesis via reg ulation of COX-2 and 15-PGDH expression in colorectal cancer cells. (PubMed id 19638428)1, 9 Moore A.E....Paraskeva C. (2009)
    376. [Expression of cyclooxygenase-2 in bone marrow cells of leukemia patients and its association with angiogenesis] (PubMed id 19236744)1, 9 Liu X.W....Zhang D.X. (2009)
    377. Expression of cyclooxygenase-2 and matrix metalloprot einase-2 in adenomyosis and endometrial polyps and its correlation with angioge nesis. (PubMed id 19188819)1, 9 Tokyol C....Arioz D.T. (2009)
    378. Expression of p-Akt and COX-2 in gastric adenocarcino mas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric ad enocarcinoma and U251 glioma cell growth in vitro and in vivo. (PubMed id 19925030)1, 9 Zhang J....Kang C.S. (2009)
    379. Involvement of mitogen-activated protein kinases and nuclear factor kappa B pathways in signaling COX-2 expression in chronic rhinos inusitis. (PubMed id 19319478)1, 9 Wang Z....Li Y. (2009)
    380. Protein kinase D mediates synergistic expression of C OX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts. (PubMed id 19794144)1, 9 Yoo J....Rozengurt E. (2009)
    381. Celecoxib potentiates the anticancer effect of cispla tin on vulvar cancer cells independently of cyclooxygenase. (PubMed id 19723114)1, 9 Kim S.H....Song Y.S. (2009)
    382. Expression of prostaglandin metabolising enzymes COX- 2 and 15-PGDH and VDR in human granulosa cells. (PubMed id 19667156)1, 9 Thill M....Friedrich M. (2009)
    383. [Effects of celecoxib on PGE2 synthesis and COX-2 and VEGF-C mRNA expression in Tca8113 cell lines.] (PubMed id 19304526)1, 9 Li W.Z....Ding Y.Q. (2009)
    384. The role of COX-2 in rectal cancer treated with preoperative radiotherapy. (PubMed id 18392637)1, 9 Bouzourene H....Coucke P. (2008)
    385. Cyclooxygenase-2 expression during immortalization and breast cancer progression. (PubMed id 18199541)1, 9 Zhao X....Band V. (2008)
    386. Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2. (PubMed id 18029351)1, 9 Xu L....Wu T. (2008)
    387. Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. (PubMed id 18237405)1, 9 Xu F....Shen H. (2008)
    388. Inhibitory effect of interferon-alpha-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice. (PubMed id 19058305)1, 9 Cao B....Shi Z.L. (2008)
    389. Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. (PubMed id 18758643)1, 9 Lazar D....Vernic C. (2008)
    390. [Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis] (PubMed id 18950008)1, 9 Cui D....Fu Y. (2008)
    391. Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. (PubMed id 17671679)1, 9 Noriyuki M....Ishiko O. (2007)
    392. Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1. (PubMed id 17968936)1, 9 Jungel A....Distler J.H. (2007)
    393. Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium. (PubMed id 17012371)1, 9 N'Guessan P.D....Hippenstiel S. (2007)
    394. [Relationship between serum VEGF level and VEGF, COX-2 and MVD expression in breast cancer tissues] (PubMed id 18069633)1, 9 Li E.X....Dong D.F. (2007)
    395. Expression of cyclooxygenase-2 and vascular endothelial growth factor in primary central nervous system lymphomas. (PubMed id 17671709)1, 9 Sugita Y....Nakashima A. (2007)
    396. EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality. (PubMed id 17290397)1, 9 Gustafsson A....Lundholm K. (2007)
    397. Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results. (PubMed id 16786043)1, 9 Mascaux C....Sculier J.P. (2006)
    398. PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. (PubMed id 16820889)1, 9 Ikezoe T....Koeffler H.P. (2006)
    399. Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. (PubMed id 16733863)1, 9 Legan M....Cor A. (2006)
    400. Molecular determinants in targeted therapy for esophageal adenocarcinoma. (PubMed id 16702519)1, 9 Vallbohmer D....DeMeester T.R. (2006)
    401. Overexpression of cyclooxygenase-2 correlates with tumor angiogenesis in endometrial carcinoma. (PubMed id 16884383)1, 9 Li W....Jiang L.H. (2006)
    402. COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. (PubMed id 15272284)1, 9 Kyzas P.A....Agnantis N.J. (2005)
    403. Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. (PubMed id 16168133)1, 9 Surowiak P....Lage H. (2005)
    404. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. (PubMed id 15863442)1, 9 Martey C.A....Phipps R.P. (2005)
    405. Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. (PubMed id 15645120)1, 9 Kuroda J....Hashimoto-Tamaoki T. (2005)
    406. The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta}. (PubMed id 15784717)1, 9 Sooranna S.R....Johnson M.R. (2005)
    407. Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. (PubMed id 16278387)1, 9 Dalwadi H....Dubinett S. (2005)
    408. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. (PubMed id 16203768)1, 9 Cianchi F....Masini E. (2005)
    409. COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. (PubMed id 14735188)1, 9 Boland G.P....Bundred N.J. (2004)
    410. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. (PubMed id 14769824)1, 9 Kuwano T....Ono M. (2004)
    411. Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium. (PubMed id 15533352)1, 9 Matsuzaki S....Mage G. (2004)
    412. Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. (PubMed id 15102673)1, 9 Cianchi F....Masini E. (2004)
    413. Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts. (PubMed id 15246970)1, 9 Miura S....Sakamoto C. (2004)
    414. Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. (PubMed id 15259059)1, 9 Jiang J.G....Wang D.W. (2004)
    415. Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. (PubMed id 14747187)1, 9 Fagotti A....Scambia G. (2004)
    416. Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts. (PubMed id 15106733)7, 9 Chae H.J....Kim H.R. (2004)
    417. Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. (PubMed id 12727794)1, 9 Maihofner C....Gooderham N.J. (2003)
    418. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. (PubMed id 12939602)1, 9 Leng J....Wu T. (2003)
    419. Variation in cyclooxygenase expression levels within the colorectum. (PubMed id 12720297)1, 9 Wiese F.W....Kadlubar F.F. (2003)
    420. Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas. (PubMed id 14550281)1, 9 Hur K....Yang H.K. (2003)
    421. Cyclooxygenase-2 inhibitor NS398 enhances antitumor effect of irradiation on hormone refractory human prostate carcinoma cells. (PubMed id 14532848)1, 9 Wen B....Bourhis J. (2003)
    422. Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. (PubMed id 12591723)1, 9 Heuze-Vourc'h N....Dubinett S.M. (2003)
    423. ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells. (PubMed id 12761889)1, 9 Tsuzaki M....Banes A.J. (2003)
    424. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. (PubMed id 12598658)1, 9 Inaba T....Nakada H. (2003)
    425. Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1. (PubMed id 12763047)1, 9 Bakker A.D....Burger E.H. (2003)
    426. Tumor necrosis factor alpha (TNF-alpha)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts. (PubMed id 12349897)1, 9 Nakao S....Sugiya H. (2002)
    427. Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. (PubMed id 11939728)1, 9 Nose F....Okayasu I. (2002)
    428. [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior] (PubMed id 12452062)1, 9 Ji S.Q....Shao Y.F. (2002)
    429. Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2). (PubMed id 11006278)7, 9 Smith T....DeWitt D. (2000)
    430. Structure-based design of COX-2 selectivity into flur biprofen. (PubMed id 10091674)7, 9 Bayly C.I....Percival M.D. (1999)
    431. Heterogeneous expression of cyclooxygenase-2 and indu cible nitric oxide synthase within colorectal tumors: correlation with tumor an giogenesis. (PubMed id 19497798)1, 9 Cianchi F....Masini E. (2010)
    432. Cigarette smoke and increased COX-2 and survivin leve ls in exhaled breath condensate of lung cancer patients: how hot is the link? (PubMed id 19423183)1, 9 Carpagnano G.E....Foschino Barbaro M.P. (2010)
    433. The endogenous cannabinoid, anandamide, induces COX-2 -dependent cell death in apoptosis-resistant colon cancer cells. (PubMed id 20514410)1, 9 Patsos H.A....Williams A.C. (2010)
    434. COX-2 expression in uterine carcinosarcoma. (PubMed id 19900134)1, 9 Menczer J....Levy T. (2010)
    435. Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis. (PubMed id 19277703)1, 9 Huh J.W....Kim Y.J. (2009)
    436. [Expressions of vascular endothelial growth factor and cyclooxygenase-2 in patients with multiple myeloma and its significance] (PubMed id 19236756)1, 9 Bao H.Y....Ruan C.G. (2009)
    437. Expression of cyclooxygenase-1 and -2 in IL-1beta-ind uced synovitis of the temporomandibular joint. (PubMed id 19141058)1, 9 Satoh K....Kondoh T. (2009)
    438. Glucocorticoid therapy increases COX-2 gene expression in nasal polyps in vivo. (PubMed id 19251796)1, 9 Pujols L....Picado C. (2009)
    439. Cross-talk between inducible nitric oxide synthase an d cyclooxygenase in Helicobacter-pylori-induced gastritis. (PubMed id 19797925)1, 9 Franco L. and Talamini G. (2009)
    440. Tpl-2/Cot and COX-2 in breast cancer. (PubMed id 18795070)1, 9 Krcova Z....Kolar Z. (2008)
    441. Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells. (PubMed id 17889855)1, 9 Tsai E.M....Lee J.N. (2008)
    442. Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. (PubMed id 19088039)1, 9 Ogino S....Fuchs C.S. (2008)
    443. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. (PubMed id 18469157)1, 9 Dillon M.F....Young L.S. (2008)
    444. Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. (PubMed id 18356024)1, 9 Pandey M....Pillai R.M. (2008)
    445. Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer. (PubMed id 18000398)1, 9 Matsubayashi H....Goggins M. (2007)
    446. Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. (PubMed id 17594159)1, 9 Lim S.C....Min Y.D. (2007)
    447. Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas. (PubMed id 17592548)1, 9 Wu R....Steinberg B.M. (2007)
    448. Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. (PubMed id 17711445)1, 9 Yuri M....Kuniyasu H. (2007)
    449. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. (PubMed id 17881124)1, 9 Boetkjaer A....Lukiw W.J. (2007)
    450. Prostacyclin production is not controlled by prostacyclin synthase but by cyclooxygenase-2 in a human follicular dendritic cell line, HK. (PubMed id 17337058)1, 9 Lee I.Y....Choe J. (2007)
    451. [COX-2 and mPGES-1 expression in carotid atherosclerotic plaques] (PubMed id 17680542)1, 9 Liu H.F....Zhang F.Q. (2007)
    452. [Expression of COX-2 and MMP-9 in cervical carcinoma and their clinical significance] (PubMed id 18069634)1, 9 Luo C.F....Lu Y.L. (2007)
    453. [The expression and significance of HIF-1alpha and COX-2 in laryngeal squamous cell carcinoma] (PubMed id 18062281)1, 9 Yin S. (2007)
    454. Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. (PubMed id 16393343)1, 9 Durrenberger P.F....Anand P. (2006)
    455. RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor. (PubMed id 16731743)1, 9 Narayanan B.A....Nargi D. (2006)
    456. Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray. (PubMed id 16481301)1, 9 Xu L....Gao H.J. (2006)
    457. IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer. (PubMed id 16574063)1, 9 Cui X....Dubinett S.M. (2006)
    458. Expression of cyclooxygenase-2 in epithelial ovarian tumors and its relation to vascular endothelial growth factor and p53 expression. (PubMed id 16515599)1, 9 Lee J.S....Min K.W. (2006)
    459. Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. (PubMed id 16343055)1, 9 Grau R....Iniguez M.A. (2006)
    460. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. (PubMed id 16505480)1, 9 Yiu G.K. and Toker A. (2006)
    461. Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. (PubMed id 15864753)1, 9 Huang S.P....Lin J.T. (2005)
    462. Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells. (PubMed id 15878911)1, 9 Abdalla S.I....Fitzgerald R.C. (2005)
    463. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. (PubMed id 16087791)1, 9 McAdam B.F....Oates J.A. (2005)
    464. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. (PubMed id 15632146)1, 9 Duque J....Iniguez M.A. (2005)
    465. The use and safety profile of non-steroidal antiinfla mmatory drugs among Turkish patients with osteoarthritis. (PubMed id 16245223)7, 9 Yilmaz H....Ozdemir O. (2005)
    466. Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. (PubMed id 15713675)1, 9 Tong X....Giardina C. (2005)
    467. Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. (PubMed id 15856454)1, 9 Sivula A....Ristimaki A. (2005)
    468. Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. (PubMed id 16005433)1, 9 Lee J....Park K. (2005)
    469. Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. (PubMed id 15550400)1, 9 Liu X.H....Levine A.C. (2005)
    470. Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. (PubMed id 15598423)7, 9 Payvandi F....Stirling D.I. (2004)
    471. Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. (PubMed id 15334675)1, 9 Sun W.H....Su H. (2004)
    472. Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. (PubMed id 15355919)1, 9 Adegboyega P.A....Powell D.W. (2004)
    473. Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. (PubMed id 15102535)7, 9 Padi S.S....Kulkarni S.K. (2004)
    474. Cyclooxygenase-2 parallels invasive depth and increased MVD in transitional cell carcinoma. (PubMed id 15450303)1, 9 Li G....Zhang Y. (2004)
    475. [Proliferation inhibition effect of indomethacin on C ML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhi bition of COX-2 expression.] (PubMed id 15730717)7, 9 Zhang G.S....Xia M. (2004)
    476. Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. (PubMed id 15151617)1, 9 Yu H.P....Xu S.Q. (2004)
    477. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. (PubMed id 15063780)1, 9 Tong X....Giardina C. (2004)
    478. [COX-2-expression in extragenital endometriosis lesions as a novel therapeutical approach?] (PubMed id 14505259)1, 9 Bartley J....Ebert A.D. (2003)
    479. PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. (PubMed id 12821125)1, 9 Eibl G....Hines O.J. (2003)
    480. Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. (PubMed id 12679908)1, 9 Li H.X....He S.X. (2003)
    481. Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer. (PubMed id 12533667)1, 9 Chu J....Rizzo M.T. (2003)
    482. Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. (PubMed id 12954496)1, 9 Gee J.R....Grossman H.B. (2003)
    483. Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. (PubMed id 12907138)1, 9 Jiang W.G....Mansel R.E. (2003)
    484. Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. (PubMed id 12592372)1, 9 Spizzo G....Obrist P. (2003)
    485. [Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer] (PubMed id 12600292)1, 9 Chen Z.K. and Ouyang Z.T. (2003)
    486. Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. (PubMed id 11809750)1, 9 Pontsler A.V....McIntyre T.M. (2002)
    487. Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. (PubMed id 11844819)1, 9 Ferrandina G....Ranelletti F.O. (2002)
    488. Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. (PubMed id 12393863)1, 9 Zeng Q....Wang C.Y. (2002)
    489. Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. (PubMed id 11948128)1, 9 Asano T....Miwa M. (2002)
    490. Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. (PubMed id 12324457)1, 9 Lim J.W....Kim K.H. (2002)
    491. Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. (PubMed id 10657949)7, 9 Yip-Schneider M.T....Sweeney C.J. (2000)
    492. Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects. (PubMed id 10381787)7, 9 Panara M.R....Patrignani P. (1999)
    493. Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebo controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group. (PubMed id 10555907)7, 9 Ehrich E.W....Gertz B.J. (1999)
    494. Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial. (PubMed id 10566562)7, 9 Malmstrom K....Desjardins P.J. (1999)
    495. Protective effect of sulforaphane on human vascular e ndothelial cells against lipopolysaccharide-induced inflammatory damage. (PubMed id 20405237)1, 9 Shan Y....Wang S. (2010)
    496. Progress in COX-2 inhibitors: a journey so far. (PubMed id 20166930)7, 9 Chakraborti A.K....Jadhavar P.S. (2010)
    497. Comparative analysis of clinicopathological correlati ons of cyclooxygenase-2 expression in resectable pancreatic cancer. (PubMed id 20397266)1, 9 Hermanova M....Dite P. (2010)
    498. Localization of cyclo-oxygenase-2 in human recurrent colorectal cancer. (PubMed id 20144265)1, 9 Loukanov T.s....MA1ller-Decker K. (2010)
    499. Cyclooxygenase-2 and 5-lipoxygenase pathways in diosg enin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. (PubMed id 20372792)1, 9 Lepage C....Beneytout J.L. (2010)
    500. Toll-like receptor 9 agonists up-regulates the expres sion of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells. (PubMed id 19618291)1, 9 Di J.M....Gao X. (2010)
    501. Antitumor effects of inhibitors of nitric oxide synth ase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. (PubMed id 20514441)1, 9 Ohtsu N....Urade M. (2010)
    502. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. (PubMed id 19723094)1, 9 Lee Y.K....Park O.J. (2009)
    503. The relationship between cyclooxygenase-2, CD44v6, an d nm23H1 in esophageal squamous cell carcinoma. (PubMed id 19816074)1, 9 Liu W.K....Zhang Z.X. (2009)
    504. Nicotinamide phosphoribosyltransferase and prostaglan din H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells aft er stimulation with interleukin-1. (PubMed id 19513556)1, 9 Bauer L....Radons J. (2009)
    505. [Effect of clarithromycin on the expressions of cyclo oxygenase-2 and nuclear factor-kappa B in nasal polyps in vitro] (PubMed id 20030038)1, 9 Zhang M....Zhang Q. (2009)
    506. The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-depen dent and -independent pathways. (PubMed id 19467701)1, 9 Chang M.C....Jeng J.H. (2009)
    507. Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. (PubMed id 19505922)1, 9 Takai T....Hishida A. (2009)
    508. The activated Notch1 signal pathway is associated wit h gastric cancer progression through cyclooxygenase-2. (PubMed id 19491270)1, 9 Yeh T.S....Chi C.W. (2009)
    509. Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. (PubMed id 19218340)1, 9 Itatsu K....Nakanuma Y. (2009)
    510. Cyclooxygenase-2 up-regulates ataxia telangiectasia a nd Rad3 related through extracellular signal-regulated kinase activation. (PubMed id 19584262)1, 9 Kim Y.M....Pyo H. (2009)
    511. Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. (PubMed id 19241124)1, 9 Kurihara Y....Shintani S. (2009)
    512. Correlation of cyclooxygenase 2 expression and inflam matory cells infiltration in colorectal cancer. (PubMed id 19579928)1, 9 Naghshvar F....Ghahremani M. (2009)
    513. Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB. (PubMed id 19940361)1, 9 Zatelli M.C....degli Uberti E. (2009)
    514. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. (PubMed id 19058955)1, 9 Madden K....Mohammed S.I. (2009)
    515. Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. (PubMed id 19287974)1, 9 Kobayashi H....Danenberg P.V. (2009)
    516. MBP-1 suppresses growth and metastasis of gastric can cer cells through COX-2. (PubMed id 19846662)1, 9 Hsu K.W....Yeh T.S. (2009)
    517. Matrix Metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps. (PubMed id 17624726)1, 9 Karahan N....Kapucuoglu N. (2009)
    518. [Expression of cyclooxygenase-2 and relationship with mismatch repair gene and microsatellite instability in hereditary non-polyposi s colorectal cancer] (PubMed id 19671325)1, 9 Zhang Y.H....Li S.R. (2009)
    519. [Expression of P53, COX2 and CD44V6 in early-stage sq uamous carcinoma of cervix with lymph vascular space invasion positive and nega tive and its relationship with prognosis] (PubMed id 20193563)1, 9 Zhang R....Wang Y. (2009)
    520. Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. (PubMed id 19318593)1, 9 Alvarez Y....FernA!ndez N. (2009)
    521. Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma. (PubMed id 19329856)1, 9 Gao Y.W....Chen W. (2009)
    522. [The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma] (PubMed id 19452725)1, 9 Bai W. and Tang J. (2009)
    523. Effects of cotreatment of 12-O-tetradecanoylphorbol-1 3-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyc looxygenase-2 signals. (PubMed id 19723105)1, 9 Lee Y.K....Park O.J. (2009)
    524. Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. (PubMed id 19217709)1, 9 Duarte M.L....Ferreira C.G. (2009)
    525. The effect of cyclooxygenase-2 expression on tumor vo lume response in patients treated with radiotherapy for uterine cervical cancer . (PubMed id 19949677)1, 9 Kang M.K....Kim B.G. (2009)
    526. Inhibition of 12-LOX and COX-2 reduces the proliferat ion of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-A kt signalling pathways. (PubMed id 19558494)1, 9 Agarwal S....Reddanna P. (2009)
    527. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. (PubMed id 19056653)1, 9 Degner S.C....Romagnolo D.F. (2009)
    528. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. (PubMed id 18326857)1, 9 Misra S....Ghatak S. (2008)
    529. Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication? (PubMed id 18718465)1, 9 Clarkin C.E....Wheeler-Jones C.P. (2008)
    530. [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] (PubMed id 18250037)1, 9 Li W.Z....Zhang J.H. (2008)
    531. [The expression of COX-2 mRNA and protein in human laryngeal squamous cell carcinoma] (PubMed id 18800677)1, 9 Chen W....Liu B. (2008)
    532. [Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma] (PubMed id 18841789)1, 9 Cui D....Zhang X. (2008)
    533. 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. (PubMed id 18555503)1, 9 Le Mee S....Morfin R. (2008)
    534. Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. (PubMed id 18395088)1, 9 Subramaniam D....Anant S. (2008)
    535. Cyclooxygenase-2 expression in human thyroid disease. (PubMed id 18362501)1, 9 Lee K.J....Soh E.Y. (2008)
    536. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. (PubMed id 18048499)1, 9 Bukulmez O....Mendelson C.R. (2008)
    537. The prognostic significance of COX-2 and survivin expression in ovarian cancer. (PubMed id 18171606)1, 9 Athanassiadou P....Patsouris E. (2008)
    538. Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. (PubMed id 18775915)1, 9 Park M.J....Cheong J. (2008)
    539. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. (PubMed id 18202756)1, 9 Niesporek S....Denkert C. (2008)
    540. COX-2/EGFR expression and survival among women with adenocarcinoma of the lung. (PubMed id 18453539)1, 9 Van Dyke A.L....Schwartz A.G. (2008)
    541. In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA. (PubMed id 18695918)1, 9 Takaoka K....Urade M. (2008)
    542. Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. (PubMed id 18462890)1, 9 Yamac D....Koybasioglu F. (2008)
    543. The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. (PubMed id 18381949)1, 9 Fidler M.J....Bonomi P. (2008)
    544. Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. (PubMed id 17553653)1, 9 Takatori H....Aikou T. (2008)
    545. Relevance of COX-2 gene expression in dementia with lewy bodies associated with Alzheimer pathology. (PubMed id 18307244)1, 9 Saldana M....Marin C. (2008)
    546. Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. (PubMed id 17962194)1, 9 Wang H....MacNaughton W.K. (2008)
    547. The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. (PubMed id 18953425)1, 9 Stasinopoulos I....Bhujwalla Z.M. (2008)
    548. Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. (PubMed id 18319253)1, 9 Pan M.R....Hung W.C. (2008)
    549. Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. (PubMed id 18262731)1, 9 Haffty B.G....Reiss M. (2008)
    550. Normal or stress-induced fibroblast senescence involves COX-2 activity. (PubMed id 17560572)1, 9 Zdanov S....Abbadie C. (2007)
    551. Increased expression of CCAAT/enhancer-binding protein beta in proliferative inflammatory atrophy of the prostate: relation with the expression of COX-2, the androgen receptor, and presence of focal chronic inflammation. (PubMed id 17570496)1, 9 Wang W....Damber J.E. (2007)
    552. Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. (PubMed id 17436372)7, 9 Kim S.J....Um J.Y. (2007)
    553. [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] (PubMed id 18159174)1, 9 Joo H.H....Choi Y.K. (2007)
    554. [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] (PubMed id 17672932)1, 9 Liu J.R....Liu J.L. (2007)
    555. Expression of glycodelin and cyclooxygenase-2 in human endometrial tissue following three-dimensional culture. (PubMed id 17156191)1, 9 Esfandiari N....Casper R.F. (2007)
    556. EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. (PubMed id 17616668)1, 9 Xu K. and Shu H.K. (2007)
    557. Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients. (PubMed id 17295901)1, 9 Chishima F....Nemoto N. (2007)
    558. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. (PubMed id 17328065)1, 9 Brechter A.B. and Lerner U.H. (2007)
    559. Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. (PubMed id 17581404)1, 9 Baltazar F....Schmitt F.C. (2007)
    560. Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus. (PubMed id 16917094)1, 9 Szerafin T....Bagi Z. (2006)
    561. Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. (PubMed id 16820089)1, 9 Crowell P.L....Cummings W.O. (2006)
    562. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. (PubMed id 16846546)7, 9 Waterbury L.D....Jolas T. (2006)
    563. Complete and long-lasting regression of disseminated multiple skin melanoma metastases under treatment with cyclooxygenase-2 inhibitor. (PubMed id 16718274)1, 9 Lejeune F.J....Ruegg C. (2006)
    564. Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. (PubMed id 16908593)1, 9 Tsai W.C....Wu L.W. (2006)
    565. Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. (PubMed id 16474989)1, 9 Soumaoro L.T....Sugihara K. (2006)
    566. Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. (PubMed id 16521222)1, 9 Li Y....Martin R.C. (2006)
    567. Significance of COX-2 expression in human esophageal squamous cell carcinoma. (PubMed id 16352617)1, 9 Zhi H....Liu Z. (2006)
    568. Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. (PubMed id 16550596)1, 9 Shimizu D....Danenberg P.V. (2006)
    569. Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. (PubMed id 16111807)1, 9 Kang S....Song Y.S. (2006)
    570. QSAR analysis of meclofenamic acid analogues as selec tive COX-2 inhibitors. (PubMed id 16290292)7, 9 Narsinghani T. and Chaturvedi S.C. (2006)
    571. Partnering between monomers of cyclooxygenase-2 homodimers. (PubMed id 16606823)1, 9 Yuan C....Smith W.L. (2006)
    572. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. (PubMed id 16723309)1, 9 Maia H....Coutinho E.M. (2006)
    573. Heregulin-alpha and heregulin-beta expression is linked to a COX-2-PGE2 pathway in human gastric fibroblasts. (PubMed id 16357062)1, 9 Nagata K....Sakamoto C. (2006)
    574. Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids. (PubMed id 15869467)1, 9 Ciccoli R....Nigam S. (2005)
    575. Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins. (PubMed id 15591227)1, 9 Rabausch K....Weber A.A. (2005)
    576. E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. (PubMed id 15800927)1, 9 Boedefeld W.M....Heslin M.J. (2005)
    577. Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. (PubMed id 15494548)7, 9 Gierse J.K....Seibert K. (2005)
    578. Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. (PubMed id 16237757)1, 9 Shida D....Nagawa H. (2005)
    579. Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis. (PubMed id 15982930)7, 9 Du G.J....Wang M.W. (2005)
    580. Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. (PubMed id 15754411)1, 9 Chen X.L....Wang Y.L. (2005)
    581. Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1. (PubMed id 15963597)1, 9 Cheng J....Hada T. (2005)
    582. [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] (PubMed id 16494037)1, 9 Sun X....Zheng C. (2005)
    583. Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis. (PubMed id 16419156)1, 9 Liu N.B....Leng J. (2005)
    584. COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. (PubMed id 15645119)1, 9 Honjo S....Ito H. (2005)
    585. Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells. (PubMed id 15950779)1, 9 Moolwaney A.S. and Igwe O.J. (2005)
    586. Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. (PubMed id 15756444)1, 9 Takatori H....Aikou T. (2005)
    587. The role of CCAAT/enhancer-binding protein beta in the transcriptional regulation of COX-2 in human amnion. (PubMed id 16399783)1, 9 Lee Y.S....Bennett P.R. (2005)
    588. Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium. (PubMed id 15599594)1, 9 Horn L.C....Leo C. (2005)
    589. Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia. (PubMed id 15276698)1, 9 Yokota O....Kuroda S. (2004)
    590. Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer. (PubMed id 15374967)1, 9 Pold M....Dubinett S.M. (2004)
    591. Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: a potential predictor of poor survival. (PubMed id 14977838)1, 9 Kim G.E....Suh C.O. (2004)
    592. Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression. (PubMed id 14555963)1, 9 Bizik J....Vaheri A. (2004)
    593. Pharmacology and gastrointestinal safety of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor: An integrated study. (PubMed id 15017615)7, 9 Atherton C....Hawkey C.J. (2004)
    594. Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis. (PubMed id 14726416)1, 9 Tanaka N....Morita I. (2004)
    595. No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor. (PubMed id 15177307)7, 9 Kalbag J....Rordorf C. (2004)
    596. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PubMed id 15574495)1, 9 Yan M.... Markowitz S.D. (2004)
    597. Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. (PubMed id 14871981)1, 9 Golijanin D....Dannenberg A.J. (2004)
    598. Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44. (PubMed id 16035618)1, 9 Kinugasa Y....Nagumo M. (2004)
    599. Prognostic role of the ratio between cyclooxygenase-2 in tumor and stroma compartments in cervical cancer. (PubMed id 15131052)1, 9 Ferrandina G....Scambia G. (2004)
    600. Cyclooxygenase-2 expression in the hereditary mixed polyposis syndrome. (PubMed id 15628724)1, 9 Brazowski E....Rozen P. (2004)
    601. Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products. (PubMed id 12837757)1, 9 Shanmugam N....Natarajan R. (2003)
    602. Interaction of rofecoxib and celecoxib with warfarin. (PubMed id 12901032)7, 9 Schaefer M.G....Egan M. (2003)
    603. Aspirin and other cyclooxygenase inhibitors: new ther apeutic insights. (PubMed id 15199473)7, 9 Wu K.K. (2003)
    604. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. (PubMed id 12750248)1, 9 Shim V....Esserman L.J. (2003)
    605. Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. (PubMed id 12555215)1, 9 Zaitsu M....Ishii E. (2003)
    606. Characterization of celecoxib and valdecoxib binding to cyclooxygenase. (PubMed id 12644588)7, 9 Hood W.F....Monahan J.B. (2003)
    607. Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. (PubMed id 14681319)1, 9 Shim J.Y....Lee K.S. (2003)
    608. Induction of cyclooxygenase-2 mRNA and protein expression in human pulp cells stimulated with black-pigmented bacteroides. (PubMed id 12701770)1, 9 Chang Y.C....Hsieh Y.S. (2003)
    609. Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. (PubMed id 12821538)1, 9 Sennlaub F....Chemtob S. (2003)
    610. Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. (PubMed id 12743126)1, 9 Abulencia J.P....Konstantopoulos K. (2003)
    611. Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. (PubMed id 12875991)1, 9 Gallo O....Capaccioli S. (2003)
    612. Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell lines. (PubMed id 12800245)1, 9 Wu G.S....Wang J.H. (2003)
    613. Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. (PubMed id 12771929)1, 9 Charalambous M.P....Gooderham N.J. (2003)
    614. p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. (PubMed id 12882963)1, 9 Dean J.L....Saklatvala J. (2003)
    615. [Relation between COX-2 protein expression and biolog ic behavior of ovarian carcinoma] (PubMed id 12839690)1, 9 Tang L.X....Ma J.W. (2003)
    616. Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. (PubMed id 12684668)1, 9 Yu J....Sung J.J. (2003)
    617. Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2. (PubMed id 14623265)1, 9 Corazzi T....Gresele P. (2003)
    618. Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. (PubMed id 14596920)1, 9 Ogawa H....Binion D.G. (2003)
    619. Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer. (PubMed id 12855643)1, 9 Davies G....Dowsett M. (2003)
    620. Clinical pharmacology of selective COX-2 inhibitors. (PubMed id 14552704)7, 9 Capone M.L....Patrignani P. (2003)
    621. Cyclooxygenase-2 expression in the gallbladder of patients with anomalous arrangement of the pancreaticobiliary duct. (PubMed id 12677571)1, 9 Fumino S....Iwai N. (2003)
    622. Mechanisms of action of paracetamol and related analgesics. (PubMed id 15035793)7, 9 Graham G.G. and Scott K.F. (2003)
    623. Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. (PubMed id 12698187)1, 9 Maaser K....Scherubl H. (2003)
    624. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. (PubMed id 14507922)1, 9 Qin W....Pasinetti G.M. (2003)
    625. Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. (PubMed id 12767532)1, 9 Shoji T....Nakamura S. (2003)
    626. Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. (PubMed id 14675489)1, 9 Carlson M.L....Prescott S.M. (2003)
    627. Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib. (PubMed id 11911965)1, 9 Patti R....Reddy C.D. (2002)
    628. Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human. (PubMed id 12167567)7, 9 Yuan J.J....Findlay J.W. (2002)
    629. Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. (PubMed id 11809691)1, 9 Sales K.J....Soeters R.P. (2002)
    630. Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer. (PubMed id 12197220)1, 9 Badawi A.F....Michael M.S. (2002)
    631. Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma. (PubMed id 11920472)1, 9 Hasturk S....Lee J.S. (2002)
    632. Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. (PubMed id 11901151)1, 9 Subbaramaiah K....Dannenberg A.J. (2002)
    633. Increased cyclooxygenase-2 expression in human squamous cell carcinomas of the head and neck and inhibition of proliferation by nonsteroidal anti-inflammatory drugs. (PubMed id 12174888)1, 9 Lee D.W....Kim K.H. (2002)
    634. Significance of cyclooxygenase-2 expression in human primary hepatocellular carcinoma. (PubMed id 12378621)1, 9 Qiu D.K....Chen X.Y. (2002)
    635. An immunohistochemical study of cyclooxygenase (COX)-2 expression in endocrine tumors of the pancreas. (PubMed id 12636104)1, 9 Okami J....Monden M. (2002)
    636. ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. (PubMed id 12143054)1, 9 Endo K....Sirica A.E. (2002)
    637. Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction. (PubMed id 11880271)1, 9 Mifflin R.C....Powell D.W. (2002)
    638. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. (PubMed id 12218179)1, 9 Rossi D.J....Makela T.P. (2002)
    639. Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. (PubMed id 12393872)1, 9 Dohadwala M....Dubinett S.M. (2002)
    640. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. (PubMed id 12072439)1, 9 Monick M.M....Hunninghake G.W. (2002)
    641. Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens. (PubMed id 11894121)1, 9 Swamy M.V....Rao C.V. (2002)
    642. In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflamm atory genes in the brain. (PubMed id 12446609)7, 9 Blais V....Rivest S. (2002)
    643. Recognition of cyclooxygenase-2 (COX-2) active site b y NSAIDs: a computer modelling study. (PubMed id 11563332)7, 9 Kothekar V....Mishra J. (2001)
    644. Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. (PubMed id 11687965)1, 9 King J.G. and Khalili K. (2001)
    645. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. (PubMed id 11275997)7, 9 Chen W.S....Yang W.K. (2001)
    646. Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells. (PubMed id 11913955)1, 9 Goldmann W.H....Sharma C.P. (2001)
    647. Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group. (PubMed id 10693877)7, 9 Hawkey C....Mortensen E. (2000)
    648. Cyclooxygenase-2 in human perinatal lung. (PubMed id 10813584)1, 9 Lassus P....Andersson S. (2000)
    649. Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. (PubMed id 10075740)1, 9 Meade E.A....Prescott S.M. (1999)
    650. Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state. (PubMed id 10340919)7, 9 Tegeder I....Geisslinger G. (1999)
    651. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. (PubMed id 10381057)7, 9 Blanco F.J....Galdo F. (1999)
    652. Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells. (PubMed id 9661070)1, 9 Min Y.K....Pilbeam C.C. (1998)
    653. Expression and selective inhibition of the constituti ve and inducible forms of human cyclo-oxygenase. (PubMed id 7832763)7, 9 Gierse J.K....Seibert K. (1995)
    654. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. (PubMed id 20028875)1, 9 Fordyce C....Tlsty T. (2010)
    655. Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lip oteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. (PubMed id 20167866)1, 9 Lee I.T....Yang C.M. (2010)
    656. TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benig n, not in malignant keratinocytes. (PubMed id 20399617)1, 9 RAosAonen K. and Vaheri A. (2010)
    657. Lipopolysaccharide promoted proliferation and invasio n of endometriotic stromal cells via induction of cyclooxygenase-2 expression. (PubMed id 19647233)1, 9 Takenaka Y....Harada T. (2010)
    658. Human glomerular endothelium: interplay among glucose , free fatty acids, angiotensin II, and oxidative stress. (PubMed id 19864304)1, 9 Jaimes E.A....Raij L. (2010)
    659. COX-2 is overexpressed in primary prostate cancer wit h metastatic potential and may predict survival. A comparison study between COX -2, TGF-beta, IL-10 and Ki67. (PubMed id 20409773)1, 9 Richardsen E....Busund L.T. (2010)
    660. The contribution of cyclooxygenase-1 and -2 to persis tent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: imp lications for antiplatelet therapy. (PubMed id 19887674)1, 9 Dragani A....Rocca B. (2010)
    661. Decreased TGFbeta signaling and increased COX2 expres sion in high risk women with increased mammographic breast density. (PubMed id 19241157)1, 9 Yang W.T....Chang J.C. (2010)
    662. Neutrophil expression of cyclooxygenase 2 in preeclam psia. (PubMed id 20220108)1, 9 Bachawaty T....Walsh S.W. (2010)
    663. Paradoxical stimulation of cyclooxygenase-2 expressio n by glucocorticoids via a cyclic AMP response element in human amnion fibrobla sts. (PubMed id 19797430)1, 9 Zhu X.O....Sun K. (2009)
    664. Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. (PubMed id 19268443)1, 9 Mariani F....Roncucci L. (2009)
    665. Regulation of prostaglandin E(2) synthesis in cells d erived from chondrocytes of patients with osteoarthritis. (PubMed id 19802674)1, 9 Shimpo H....Ishiguro N. (2009)
    666. Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. (PubMed id 19203995)1, 9 Chang K.Y....Chen B.K. (2009)
    667. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. (PubMed id 18617679)1, 9 Zhao Y....Natarajan V. (2009)
    668. R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. (PubMed id 19015962)1, 9 Eichele K....Hinz B. (2009)
    669. Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signalin g pathway at low-dose H2O2. (PubMed id 19723101)1, 9 Park I.J....Park O.J. (2009)
    670. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (PubMed id 19638987)1, 9 Doherty G.A....Fitzgerald D.J. (2009)
    671. Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts. (PubMed id 19616539)1, 9 Shih C.H....Chen B.C. (2009)
    672. Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. (PubMed id 19639178)1, 9 Fu Y....Wang T. (2009)
    673. Cyclooxygenase-2 expression in astrocytes and microgl ia in human oligodendroglioma and astrocytoma. (PubMed id 20052522)1, 9 Temel S.G. and Kahveci Z. (2009)
    674. Cyclooxygenase-2 expression on urothelial and inflammatory cells of cystoscopic biopsies and urine cytology as a possible predictive marker for bladder carcinoma. (PubMed id 19161536)1, 9 Moussa M....Swellam T. (2009)
    675. The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers. (PubMed id 18720000)1, 9 Yoshinaga M....Muto Y. (2009)
    676. COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. (PubMed id 19862936)1, 9 Ishiura Y....Myou S. (2009)
    677. Cyclic stretch induces cyclooxygenase-2 gene expressi on in vascular endothelial cells via activation of nuclear factor kappa-beta. (PubMed id 19748489)1, 9 Zhao H....Rade J.J. (2009)
    678. Increased cyclooxygenase-2 expression in juvenile polyposis syndrome. (PubMed id 19124115)1, 9 van Hattem W.A....Offerhaus G.J. (2009)
    679. Expression of cyclooxygenase-2 in ovarian serous carc inoma: correlation with angiogenesis, nm23 expression and survival. (PubMed id 20099494)1, 9 Ozuysal S....Evrensel T. (2009)
    680. COX-2 expression is unexpectedly high in viable color ectal mucosal cells: is there life for chemoprophylaxis after VICTOR? (PubMed id 18691269)1, 9 McArthur D.R....Williams N. (2009)
    681. Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. (PubMed id 19084589)1, 9 Jang B.C. (2009)
    682. [Effects of cyclooxygenase-2 and proliferating cell n uclear antigen on the onset and development of familial adenomatous polyposis] (PubMed id 19895739)1, 9 Zhang Y.H....Li S.R. (2009)
    683. Inhibition of cyclooxygenase-2 down-regulates aromata se activity and decreases proliferation of Leydig tumor cells. (PubMed id 19679653)1, 9 Sirianni R....Pezzi V. (2009)
    684. [The effect of simultaneously blocking target epiderm al growth factor receptor tyrosine kinase and cyclooxygenase-2 on the growth of NPC cell] (PubMed id 20120857)1, 9 Li S.S....Tian Y. (2009)
    685. Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. (PubMed id 19127598)1, 9 Swami S....Feldman D. (2009)
    686. COX-2 limits prostanoid production in activated HUVEC s and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells. (PubMed id 19423863)1, 9 Salvado M.D....Redondo J.M. (2009)
    687. Prognostic significance of cyclooxygenase-2 overexpression in glottic cancer. (PubMed id 18172254)1, 9 Sackett M.K....Tetu B. (2008)
    688. Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. (PubMed id 18288396)1, 9 Goto R....Mori N. (2008)
    689. Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium- and protein kinase C zeta-dependent. (PubMed id 18094075)1, 9 Jerde T.J....Nakada S.Y. (2008)
    690. Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation. (PubMed id 18798061)1, 9 Gu P....Cai Y. (2008)
    691. Pro-inflammatory gene variants in myocardial infarction and longevity: implications for pharmacogenomics. (PubMed id 18991687)1, 9 Listi F....Candore G. (2008)
    692. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. (PubMed id 17884974)7, 9 Hinz B....Brune K. (2008)
    693. Forced COX-2 expression induces PGE(2) and invasion in immortalized urothelial cells. (PubMed id 18367112)1, 9 Gee J....Sabichi A.L. (2008)
    694. The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. (PubMed id 18165598)1, 9 Gordon S.M....Dionne R.A. (2008)
    695. Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. (PubMed id 18441204)1, 9 Syeda F....Zhang H. (2008)
    696. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. (PubMed id 18378414)1, 9 Erdemoglu E....Mungan T. (2008)
    697. Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production. (PubMed id 18297687)1, 9 Lee S.K....Lee W.J. (2008)
    698. Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice. (PubMed id 18611916)1, 9 Leung W.K....Sung J.J. (2008)
    699. Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. (PubMed id 18817855)1, 9 Fujimori K....Urade Y. (2008)
    700. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. (PubMed id 18039779)1, 9 Banu S.K....Arosh J.A. (2008)
    701. EGFR, HER-2 and COX-2 levels in colorectal cancer. (PubMed id 19102009)1, 9 Antonacopoulou A.G....Kalofonos H.P. (2008)
    702. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. (PubMed id 18285462)1, 9 Doller A....Eberhardt W. (2008)
    703. Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells. (PubMed id 18097055)1, 9 Blanco A....Munoz-Fernandez M.A. (2008)
    704. Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells. (PubMed id 19116446)1, 9 Jeong K.J....Lee H.Y. (2008)
    705. Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. (PubMed id 18717758)1, 9 Zhuang Z.H....Wong B.C. (2008)
    706. Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. (PubMed id 19074839)1, 9 Zhang W....Siegfried J.M. (2008)
    707. 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. (PubMed id 18192694)1, 9 Kim E.H....Surh Y.J. (2008)
    708. COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. (PubMed id 18462368)1, 9 McLean M.H....El-Omar E.M. (2008)
    709. COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. (PubMed id 18632220)1, 9 Dawsey S.P....Woodson K. (2008)
    710. The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. (PubMed id 18571838)1, 9 Venerito M....Treiber G. (2008)
    711. Mannan and peptidoglycan induce COX-2 protein in human PMN via the mammalian target of rapamycin. (PubMed id 17683115)1, 9 Fernandez N....Crespo M.S. (2007)
    712. Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells. (PubMed id 17133356)1, 9 Duggan S.V....Bartlett S.R. (2007)
    713. Global gastrointestinal safety profile of etoricoxib and lumiracoxib. (PubMed id 17691997)7, 9 Yuan Y. and Hunt R.H. (2007)
    714. Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. (PubMed id 17128412)1, 9 Mori F....Lazzaro D. (2007)
    715. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. (PubMed id 17143555)1, 9 Liagre B....Beneytout J.L. (2007)
    716. An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. (PubMed id 17604853)1, 9 Ansorge N....Schmitz F. (2007)
    717. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. (PubMed id 17645803)1, 9 Costa V.L....Jeronimo C. (2007)
    718. Cyclooxygenase-2 expression in astrocytomas. Relationship with microvascular parameters, angiogenic factors expression and survival. (PubMed id 16868662)1, 9 Perdiki M....Patsouris E. (2007)
    719. Cardiovascular effects of the selective cyclooxygenase-2 inhibitors. (PubMed id 17612049)7, 9 White W.B. (2007)
    720. Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. (PubMed id 17265445)1, 9 Denkert C....Kristiansen G. (2007)
    721. [Effects of RNA interference of COX-2 gene expression on malignant proliferation of A549 cells in vitro] (PubMed id 18478928)1, 9 Li W.Y....Zhang C.Y. (2007)
    722. In regard to Ishikawa et al.: Cyclooxygenase-2 impairs treatment effect of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis (Int J Radiat Oncol Biol Phys 2006;66:1347-1355). (PubMed id 17544005)1, 9 Herrera F.G....Milosevic M. (2007)
    723. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. (PubMed id 17724132)1, 9 Ghosh M....Hla T. (2007)
    724. Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. (PubMed id 18085997)1, 9 Skarke C....Lotsch J. (2007)
    725. Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. (PubMed id 18027256)1, 9 Cho N.P....Son H.J. (2007)
    726. Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. (PubMed id 17876541)1, 9 Mutoh H....Sugano K. (2007)
    727. Pharmacodynamic of cyclooxygenase inhibitors in humans. (PubMed id 17164136)7, 9 Capone M.L....Patrignani P. (2007)
    728. Cyclooxygenase-2 (COX-2) overexpression in meningiomas: real time PCR and immunohistochemistry. (PubMed id 17525632)1, 9 Buccoliero A.M....Taddei G.L. (2007)
    729. Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms. (PubMed id 17707579)1, 9 Deasy B.M....O'Sullivan G.C. (2007)
    730. Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study. (PubMed id 17457030)1, 9 Fujimi K....Iwaki T. (2007)
    731. Cyclooxygenase-2 mRNA expression correlates with aromatase expression in human breast cancer. (PubMed id 17657731)1, 9 Salhab M....Mokbel K. (2007)
    732. Cell proliferation activity unrelated to COX-2 expression in ovarian tumors. (PubMed id 17504375)1, 9 Yoshida A....Derchain S.F. (2007)
    733. Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer. (PubMed id 17550984)1, 9 Siegfried J.M....Stabile L.P. (2007)
    734. Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. (PubMed id 17105783)1, 9 Astle S....Slater D.M. (2007)
    735. Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations. (PubMed id 17624243)1, 9 Pannone G....Bufo P. (2007)
    736. Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cells. (PubMed id 17405913)1, 9 Seo J.H....Kim H. (2007)
    737. [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas] (PubMed id 18330256)1, 9 Li J....Pan Z. (2007)
    738. Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on lung cancer: roles of cyclooxygenase-2. (PubMed id 17342342)1, 9 Uemura Y....Taguchi H. (2007)
    739. Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. (PubMed id 17434257)1, 9 Fernandez-Martinez A.B....Carmena M.J. (2007)
    740. Association of COX-2 expression with corresponding active and chronic inflammatory reactions in Barrett's metaplasia and progression to cancer. (PubMed id 17222248)1, 9 Ling F.C....Schneider P.M. (2007)
    741. Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA. (PubMed id 17016639)1, 9 Takaoka K....Urade M. (2006)
    742. Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches. (PubMed id 16498361)1, 9 Brueggemeier R.W. and Diaz-Cruz E.S. (2006)
    743. RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. (PubMed id 17178865)1, 9 Chang Y.W....Jakobi R. (2006)
    744. Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. (PubMed id 16820091)1, 9 Ogino S....Fuchs C.S. (2006)
    745. Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction. (PubMed id 16820795)1, 9 Norregaard R....Frokiaer J. (2006)
    746. Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB. (PubMed id 16212965)1, 9 Gomez-Hernandez A....Egido J. (2006)
    747. COX-2 induction by heparanase in the progression of breast cancer. (PubMed id 16391819)1, 9 Imada T....Naomoto Y. (2006)
    748. The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. (PubMed id 16699180)1, 9 Eisinger A.L....Jones D.A. (2006)
    749. Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. (PubMed id 16414978)1, 9 N'Guessan P.D....Schmeck B. (2006)
    750. Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. (PubMed id 16371352)1, 9 Thiel A....Ristimaki A. (2006)
    751. Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. (PubMed id 16326073)1, 9 Duque J....Iniguez M.A. (2006)
    752. Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. (PubMed id 16473553)1, 9 Ryan E.P....Phipps R.P. (2006)
    753. Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. (PubMed id 17050798)7, 9 Poggi J.C....dos Reis M.L. (2006)
    754. Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. (PubMed id 16331686)1, 9 Han C....Wu T. (2006)
    755. Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. (PubMed id 17003477)1, 9 Feldon S.E....Phipps R.P. (2006)
    756. Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. (PubMed id 17033106)7, 9 Brzozowski T....Pawlik W.W. (2006)
    757. NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. (PubMed id 16822500)1, 9 Santhi W.S....Pillai M.R. (2006)
    758. Proapoptotic activity of NAG-1 is cell type specific and not related to COX-2 expression. (PubMed id 16699947)1, 9 Jang T.J....Lee C.H. (2006)
    759. Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. (PubMed id 16998585)1, 9 Dixon D.A....Zimmerman G.A. (2006)
    760. Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. (PubMed id 16926398)1, 9 Rydkina E....Sahni S.K. (2006)
    761. Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts. (PubMed id 17097611)1, 9 Ogata S....Shirasuna K. (2006)
    762. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. (PubMed id 16681998)1, 9 Zhang W.Y....Zhu X.Z. (2006)
    763. Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. (PubMed id 16474375)1, 9 Milne A.N....Offerhaus G.J. (2006)
    764. LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. (PubMed id 16912160)1, 9 Upadhyay S....Sidransky D. (2006)
    765. Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk. (PubMed id 16808554)7, 9 Motsko S.P....Worchel J. (2006)
    766. Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. (PubMed id 16682957)1, 9 Benoit V....Hainaut P. (2006)
    767. Endothelial cell COX-2 expression and activity in hypoxia. (PubMed id 17046322)1, 9 Cook-Johnson R.J....James M.J. (2006)
    768. IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. (PubMed id 15950941)1, 9 Heuze-Vourc'h N....Dubinett S.M. (2005)
    769. Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. (PubMed id 16001969)1, 9 Alvarez S....Munoz-Fernandez M. (2005)
    770. Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells. (PubMed id 15569856)1, 9 Kohlstedt K....Fleming I. (2005)
    771. Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. (PubMed id 15867220)1, 9 Wang W....Damber J.E. (2005)
    772. COX-2 inhibitors and metabolism of essential fatty acids. (PubMed id 15990700)7, 9 Das U.N. (2005)
    773. Prognostic importance of COX-2 expression in patients with colorectal cancer. (PubMed id 16164044)1, 9 Yamac D....Koybasioglu F. (2005)
    774. Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. (PubMed id 16110762)1, 9 Arnoletti J.P....Watson J.C. (2005)
    775. Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. (PubMed id 16157291)1, 9 Sakurai M....Watanabe K. (2005)
    776. High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. (PubMed id 15817909)1, 9 Lo C.Y....Luk J.M. (2005)
    777. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. (PubMed id 15461587)1, 9 Clark S.R....O'Donnell V.B. (2005)
    778. Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. (PubMed id 15843495)1, 9 Ackerman W.E....Kniss D.A. (2005)
    779. Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. (PubMed id 16076963)1, 9 Hinz B....Brune K. (2005)
    780. Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. (PubMed id 15878334)1, 9 Liou J.Y....Wu K.K. (2005)
    781. Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. (PubMed id 15870920)1, 9 Yoshimoto A....Nakao S. (2005)
    782. Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients. (PubMed id 16097073)1, 9 Zhang J.T....Yu J. (2005)
    783. Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? (PubMed id 16190133)7, 9 Das U.N. (2005)
    784. In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis. (PubMed id 15943176)7, 9 Ozgocmen S....Gudul H. (2005)
    785. Effect of specific and non-specific inhibition of COX-2 on renal oxygenation before and after water diuresis. (PubMed id 15692221)1, 9 Gilbert S....Epstein F.H. (2005)
    786. Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. (PubMed id 16256948)1, 9 Rosch S....Hinz B. (2005)
    787. Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas. (PubMed id 15067173)1, 9 Onguru O....Lloyd R.V. (2004)
    788. Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression. (PubMed id 15221958)1, 9 Han S....Roman J. (2004)
    789. Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta. (PubMed id 15146435)1, 9 Morgan M.P....McCarthy G.M. (2004)
    790. Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. (PubMed id 15069531)1, 9 Hill K.A....Rao M.S. (2004)
    791. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. (PubMed id 15050918)1, 9 Crawford Y.G....Tlsty T.D. (2004)
    792. Comparison of Lornoxicam and Rofecoxib in Patients wi th Activated Osteoarthritis (COLOR Study). (PubMed id 17516707)7, 9 Rose P. and Steinhauser C. (2004)
    793. Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor. (PubMed id 15838264)1, 9 Spinella F....Bagnato A. (2004)
    794. Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance. (PubMed id 15484698)1, 9 Buccoliero A.M....Taddei G.L. (2004)
    795. The correlation between cyclooxygenase-2 expression and hepatocellular carcinogenesis. (PubMed id 15055524)1, 9 Sung Y.K....Kim M.K. (2004)
    796. Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. (PubMed id 15456329)7, 9 Hedner T....Ekbom A. (2004)
    797. Role of cyclooxygenase-2 in colorectal cancer. (PubMed id 15000150)1, 9 Sinicrope F.A. and Gill S. (2004)
    798. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. (PubMed id 15319438)1, 9 Hung J.H....Lai M.D. (2004)
    799. Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. (PubMed id 15481334)7, 9 Gallego-SandA-n S....Abad-Santos F. (2004)
    800. Gastrointestinal and hepatic toxicity of selective an d non-selective cyclooxygenase-2 inhibitors in pregnant and non-pregnant rats. (PubMed id 15458776)7, 9 Burdan F....Klepacz L. (2004)
    801. Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. (PubMed id 14991384)1, 9 Yokota O....Kuroda S. (2004)
    802. Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. (PubMed id 14984594)1, 9 Fogel-Petrovic M....Upham J.W. (2004)
    803. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. (PubMed id 15361550)1, 9 Hinz B....Brune K. (2004)
    804. Hypoxic regulation of angiopoietin-2 expression in endothelial cells. (PubMed id 14702352)1, 9 Pichiule P....LaManna J.C. (2004)
    805. Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. (PubMed id 13680221)1, 9 Shinmura K....Imakiire A. (2004)
    806. Expression of COX-2 proteins in gastric mucosal lesions. (PubMed id 14716842)1, 9 Yu L.Z....Zhao Z.Q. (2004)
    807. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. (PubMed id 14724276)1, 9 Nagano S....Bush A.I. (2004)
    808. COX-2-dependent stabilization of survivin in non-small cell lung cancer. (PubMed id 14597555)1, 9 Krysan K....Dubinett S. (2004)
    809. Clinical pharmacology of novel selective COX-2 inhibitors. (PubMed id 14965322)7, 9 Tacconelli S....Patrignani P. (2004)
    810. Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. (PubMed id 15274307)1, 9 Honjo S....Ito H. (2004)
    811. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. (PubMed id 14729623)1, 9 Denkert C....Hauptmann S. (2004)
    812. Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. (PubMed id 15248379)1, 9 Sheehan K.M....Murray F.E. (2004)
    813. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. (PubMed id 14744769)1, 9 Su J.L....Kuo M.L. (2004)
    814. [Prognostic role and regulation of cyclooxygenase-2 (COX-2) in ovarian carcinoma] (PubMed id 15478052)1, 9 Denkert C. (2004)
    815. Valdecoxib: a review. (PubMed id 12852704)7, 9 Chavez M.L. and DeKorte C.J. (2003)
    816. Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. (PubMed id 12578839)1, 9 Sawaoka H....Boutaud O. (2003)
    817. Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. (PubMed id 12789263)1, 9 Rosell R....Stephens C. (2003)
    818. Neutrophil elastase stimulates human airway epithelial cells to produce PGE2 through activation of p44/42 MAPK and upregulation of cyclooxygenase-2. (PubMed id 12832284)1, 9 Perng D.W....Lee Y.C. (2003)
    819. Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. (PubMed id 14669280)1, 9 Roland I.H....Xu X.X. (2003)
    820. Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. (PubMed id 14534699)1, 9 Ferrandina G....Scambia G. (2003)
    821. Expression of cyclooxygenase-2 in human hyperplastic gastric polyps. (PubMed id 14582702)1, 9 Bamba H....Fujiwara K. (2003)
    822. Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. (PubMed id 12852483)7, 9 Cappon G.D....Hurtt M.E. (2003)
    823. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. (PubMed id 12626523)1, 9 Kamei D....Kudo I. (2003)
    824. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. (PubMed id 14530307)1, 9 Meyer F....Wilson K.T. (2003)
    825. Effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral TA3 supernatant on CAM from chick embryo. (PubMed id 14513718)7, 9 ZA_A+iga J....Lemus D. (2003)
    826. Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. (PubMed id 12784332)1, 9 Denkert C....Hauptmann S. (2003)
    827. Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. (PubMed id 12534640)7, 9 Kirchheiner J....Brockmoller J. (2003)
    828. PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells. (PubMed id 12800228)1, 9 Li M.Y....Tan X.Y. (2003)
    829. Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. (PubMed id 12782823)1, 9 Sung M.W....Kim K.H. (2003)
    830. Cyclo-oxygenase-2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans. (PubMed id 12813143)1, 9 Langberg H....Kjaer M. (2003)
    831. Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. (PubMed id 14517215)1, 9 Bradbury D.A....Knox A.J. (2003)
    832. Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor. (PubMed id 12824918)7, 9 Chen W.S....Yang W.K. (2003)
    833. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. (PubMed id 12573452)7, 9 Ait-Said F....Hatmi M. (2003)
    834. [Pharmacology of cyclooxygenase 2 inhibition] (PubMed id 12705061)7, 9 Beubler E. (2003)
    835. Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. (PubMed id 12401798)1, 9 Liu X.H....Levine A.C. (2002)
    836. Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. (PubMed id 12450219)1, 9 Xiang Z....Pasinetti G.M. (2002)
    837. Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production. (PubMed id 12145315)1, 9 Han R. and Smith T.J. (2002)
    838. Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. (PubMed id 12444028)1, 9 Yang X....Morrell N.W. (2002)
    839. 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonami des as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). (PubMed id 11906292)1, 9 Hashimoto H....Wakitani K. (2002)
    840. Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. (PubMed id 12050157)1, 9 Bazan N.G. and Lukiw W.J. (2002)
    841. Cyclooxygenase-2 expression by transcription factors in Helicobacter pylori-infected gastric epithelial cells: comparison between HP 99 and NCTC 11637. (PubMed id 12485915)1, 9 Seo J.H....Kim K.H. (2002)
    842. Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. (PubMed id 11897504)1, 9 Richards J.A....Brueggemeier R.W. (2002)
    843. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. (PubMed id 11847219)1, 9 Han R....Smith T.J. (2002)
    844. Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. (PubMed id 12391278)1, 9 Wort S.J....Mitchell J.A. (2002)
    845. Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells. (PubMed id 12205039)1, 9 Pang L....Knox A.J. (2002)
    846. Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. (PubMed id 12664576)1, 9 Hsi L.C....Eling T.E. (2002)
    847. Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. (PubMed id 12208114)7, 9 Cipolla G....Frigo G. (2002)
    848. Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. (PubMed id 12405290)1, 9 Konno H....Nakamura S. (2002)
    849. The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity. (PubMed id 12564662)7, 9 Tacconelli S....Patrignani P. (2002)
    850. Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders. (PubMed id 12397176)1, 9 Frungieri M.B....Mayerhofer A. (2002)
    851. Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. (PubMed id 12209724)1, 9 Ferrandina G....Lauriola L. (2002)
    852. Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. (PubMed id 11891188)1, 9 Denkert C....Hauptmann S. (2002)
    853. Pharmacokinetic and pharmacodynamic aspects of the id eal COX-2 inhibitor: a pharmacologist's perspective. (PubMed id 11695253)7, 9 Brune K. and Neubert A. (2001)
    854. Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. (PubMed id 11705852)1, 9 Bing R.J....Shi S.R. (2001)
    855. Rofecoxib: a review of its use in the management of o steoarthritis, acute pain and rheumatoid arthritis. (PubMed id 11398914)7, 9 Matheson A.J. and Figgitt D.P. (2001)
    856. Aromatase and COX-2 expression in human breast cancers. (PubMed id 11850206)1, 9 Brodie A.M....Thijssen J.H. (2001)
    857. Evaluation of intravenous parecoxib for the relief of acute post-surgical pain. (PubMed id 11060833)7, 9 Jain K.K. (2000)
    858. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamid e, valdecoxib: a potent and selective inhibitor of COX-2. (PubMed id 10715145)7, 9 Talley J.J....Seibert K. (2000)
    859. A comparison of the effects of etodolac and ibuprofen on renal haemodynamics, tubular function, renin, vasopressin and urinary excre tion of albumin and alpha-glutathione-S-transferase in healthy subjects: a plac ebo-controlled cross-over study. (PubMed id 11009046)7, 9 Svendsen K.B....Pedersen E.B. (2000)
    860. Renal damage induced by the treatment with non-opioid analgesics--theoretical assumption or clinical significance. (PubMed id 11153163)7, 9 Fackovcova D....Kriska M. (2000)
    861. Sulindac sulfone inhibits K-ras-dependent cyclooxygen ase-2 expression in human colon cancer cells. (PubMed id 11118042)7, 9 Taylor M.T....Gerner E.W. (2000)
    862. Germline alterations in the cyclooxygenase-2 gene are not associated with the development of extracolonic manifestations in a large swiss familial adenomatous polyposis kindred. (PubMed id 10956391)4, 9 Humar B....Dobbie Z. (2000)
    863. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. (PubMed id 10485483)7, 9 Molina M.A....Sinicrope F.A. (1999)
    864. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. (PubMed id 10450786)7, 9 Berg J....Stimmeder D. (1999)
    865. Ex vivo assay to determine the cyclooxygenase selecti vity of non-steroidal anti-inflammatory drugs. (PubMed id 10372826)7, 9 Giuliano F. and Warner T.D. (1999)
    866. Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. (PubMed id 10594327)7, 9 Kusuhara H....Sugahara K. (1999)
    867. [New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase] (PubMed id 9711054)7, 9 Stichtenoth D.O....FrAPlich J.C. (1998)
    868. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. (PubMed id 9626023)7, 9 Cryer B. and Feldman M. (1998)
    869. Budesonide epimer R or dexamethasone selectively inhibit platelet- activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. (PubMed id 9520467)1, 9 Lukiw W.J.... Bazan N.G. (1998)
    870. Cyclooxygenase selectivity and the risk of gastro-int estinal complications of various non-steroidal anti-inflammatory drugs: a clini cal consideration. (PubMed id 9831331)7, 9 Kawai S. (1998)
    871. Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. (PubMed id 9253954)7, 9 Capasso A. and Sorrentino L. (1997)
    872. Molecular markers of therapeutic resistance in breast cancer. (PubMed id 23434145)1 Zhou L....Huang Q. (2013)
    873. Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy. (PubMed id 23449721)1 Matthaei M....Jun A.S. (2013)
    874. Cox-2 gene variants in migraine. (PubMed id 23357220)1 Dasdemir S....Cakmakoglu B. (2013)
    875. COX-2 and PPAR-g confer cannabidiol-induced apoptosis of human lung cancer cells. (PubMed id 23220503)1 Ramer R....Hinz B. (2013)
    876. Interrelationship and expression profiling of cyclooxy genase and angiogenic factors in Indian patients with multiple myeloma. (PubMed id 22971811)1 Khan R....Sharma A. (2013)
    877. AML1-ETO mediates hematopoietic self-renewal and leuke mogenesis through a COX/b-catenin signaling pathway. (PubMed id 23645839)1 Zhang Y....Yeh J.R. (2013)
    878. Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4, and ROS-dependent COX-2-derived prostanoids. (PubMed id 23232839)1 Wong W.T....Huang Y. (2013)
    879. Cyclooxygenase-2 expression and clinical parameters in laryngeal squamous cell carcinoma, vocal fold nodule, and laryngeal atypical hy perplasia. (PubMed id 22247036)1 Sayar C....Kemal Olgun M. (2013)
    880. The impact of PLA2G4A and PTGS2 gene polymorphisms, an d red blood cell PUFAs deficit on niacin skin flush response in schizophrenia pa tients. (PubMed id 23219238)1 Nadalin S....Buretic-Tomljanovic A. (2013)
    881. Eicosanoid modulation by the short-chain fatty acid n- butyrate in human monocytes. (PubMed id 23398566)1 Kovarik J.J....Zlabinger G.J. (2013)
    882. Platelet response to aspirin in Chinese stroke patient s is independent of genetic polymorphisms of COX-1 C50T and COX-2 G765C. (PubMed id 22972377)1 Yi X....Han Z. (2013)
    883. COX-2 overexpression Induced by gene transfer reduces sensitivity of TE13 esophageal carcinoma cells to 5-fluorouracil and cisplatin. (PubMed id 23393346)1 Okamura H....Otsuji E. (2013)
    884. The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regul ates COX-2. (PubMed id 23261444)1 Shimokawa M....Ozawa M. (2013)
    885. ATP mediates NADPH oxidase/ROS generation and COX-2/PG E2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation. (PubMed id 23326583)1 Cheng S.E....Yang C.M. (2013)
    886. Prognostic significance of cyclooxygenase-2 in cervica l cancer: a meta-analysis. (PubMed id 22729746)1 Huang M....Zhao X. (2013)
    887. Intestinal anti-inflammatory activity of red wine extr act: unveiling the mechanisms in colonic epithelial cells. (PubMed id 23233037)1 Nunes C....Laranjinha J. (2013)
    888. Cyclooxygenase-2 over-expression inhibits liver apopto sis induced by hyperglycemia. (PubMed id 23059845)1 Frances D.E....Carnovale C.E. (2013)
    889. The effects of oral and enteric Campylobacter concisus strains on expression of TLR4, MD-2, TLR2, TLR5 and COX-2 in HT-29 cells. (PubMed id 23437263)1 Ismail Y....Zhang L. (2013)
    890. Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) pr omotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. (PubMed id 23564449)1 Gao R....Wadhwa R. (2013)
    891. Prognostic significance of COX-2 expression and correl ation with Bcl-2 and VEGF expression, microvessel density, and clinical variable s in classical Hodgkin lymphoma. (PubMed id 23851330)1 Koh Y.W....Huh J. (2013)
    892. Role of LOXs and COX-2 on FAK activation and cell migr ation induced by linoleic acid in MDA-MB-231 breast cancer cells. (PubMed id 23179791)1 Serna-Marquez N....Salazar E.P. (2013)
    893. Association of COX-2 rs20417 with aspirin resistance. (PubMed id 22763923)1 Sharma V....Munshi A. (2013)
    894. COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: a quanti tative immunohistochemical analysis of RTOG C0128. (PubMed id 23221733)1 Doll C.M....Magliocco A.M. (2013)
    895. Cyclooxygenase-2 generates the endogenous mutagen tran s-4-hydroxy-2-nonenal in Enterococcus faecalis-infected macrophages. (PubMed id 23321929)1 Wang X....Huycke M.M. (2013)
    896. Necrosis in DU145 prostate cancer spheroids induces CO X-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activatio n. (PubMed id 23536473)1 Sha W....Brune B. (2013)
    897. The association between cyclooxygenase-2 1195 G/A poly morphism and hepatocellular carcinoma: evidence from a meta-analysis. (PubMed id 23494177)1 Bu X. and Zhao C. (2013)
    898. Endothelin-1 enhances cell migration through COX-2 up- regulation in human chondrosarcoma. (PubMed id 23523690)1 Wu M.H....Tang C.H. (2013)
    899. Increased expression of sphingosine kinase in the amni on during labor. (PubMed id 23462226)1 Erkhembaatar L.O....Kikkawa F. (2013)
    900. Cyclooxygenase-2 up-regulates CCR7 expression via AKT- mediated phosphorylation and activation of Sp1 in breast cancer cells. (PubMed id 22718198)1 Chuang C.W....Hung W.C. (2013)
    901. Adipose-derived mesenchymal stem cells exert antiinfla mmatory effects on chondrocytes and synoviocytes from osteoarthritis patients th rough prostaglandin E2. (PubMed id 23613363)1 Manferdini C....Lisignoli G. (2013)
    902. Melanoma-educated CD14+ cells acquire a myeloid-derive d suppressor cell phenotype through COX-2-dependent mechanisms. (PubMed id 23633486)1 Mao Y....Kiessling R. (2013)
    903. Seminal plasma induces prostaglandin-endoperoxide synt hase (PTGS) 2 expression in immortalized human vaginal cells: involvement of sem en prostaglandin E2 in PTGS2 upregulation. (PubMed id 23153564)1 Joseph T....Doncel G.F. (2013)
    904. Prognostic significance of COX-2 immunohistochemical e xpression in colorectal cancer: a meta-analysis of the literature. (PubMed id 23527044)1 Peng L....Zhao Q. (2013)
    905. Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily. (PubMed id 23431194)1 Sjogren T.... Geschwindner S. (2013)
    906. PI3K mediates stretch-induced COX-2 expression during urinary tract obstruction. (PubMed id 22998445)1 Owusu-Ofori K....Nakada S.Y. (2013)
    907. Gastrin acting on the cholecystokinin2 receptor induce s cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastr ic cancer cells. (PubMed id 23376640)1 Xu W....Sun W.H. (2013)
    908. Stretch magnitude- and frequency-dependent cyclooxygen ase 2 and prostaglandin E2 up-regulation in human endometrial stromal cells: pos sible implications in endometriosis. (PubMed id 23239446)1 Li X....Fan Y. (2012)
    909. Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? (PubMed id 23520664)1 Jana D....Ganguly S. (2012)
    910. Cyclooxygenase-2 expression in bladder cancer and pati ent prognosis: results from a large clinical cohort and meta-analysis. (PubMed id 23028744)1 Czachorowski M.J....Malats N. (2012)
    911. Increased expression of IL-6 family members in tendon pathology. (PubMed id 22337942)1 Legerlotz K....Riley G.P. (2012)
    912. Prostaglandin H synthase-2-catalyzed oxygenation of 2- arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arac hidonic acid. (PubMed id 22942274)1 Musee J. and Marnett L.J. (2012)
    913. A seven-marker signature and clinical outcome in malig nant melanoma: a large-scale tissue-microarray study with two independent patien t cohorts. (PubMed id 22685558)1 Meyer S....Wild P.J. (2012)
    914. Interplay between membrane lipid peroxidation, transgl utaminase activity, and cyclooxygenase 2 expression in the tissue adjoining to b reast cancer. (PubMed id 21678409)1 Balestrieri M.L....Stiuso P. (2012)
    915. The mRNA stability factor HuR inhibits microRNA-16 tar geting of COX-2. (PubMed id 22049153)1 Young L.E....Dixon D.A. (2012)
    916. Systematic review and meta-analysis of COX-2 expressio n and polymorphisms in prostate cancer. (PubMed id 23053989)1 Shao N....Hua L. (2012)
    917. Targeting COX-2/PGE(2) pathway in HIPK2 knockdown canc er cells: impact on dendritic cell maturation. (PubMed id 23144866)1 Garufi A....D'Orazi G. (2012)
    918. Immunoexpression of cyclooxygenase-2 in primary gastri c carcinomas and lymph node metastases. (PubMed id 22371637)1 Almeida P.R....Ribeiro R.A. (2012)
    919. Promoter methylation regulates cigarette smoke-stimula ted cyclooxygenase-2 expression in esophageal squamous cell carcinoma. (PubMed id 22435505)1 Meng X.Y....Zhang S.T. (2012)
    920. [Small interfering RNA in silencing cox-2 expression e nhances radiosensitivity of esophageal cancer EC9706 cell]. (PubMed id 22944132)1 Wu H....Fan Q.X. (2012)
    921. Correlation of prostaglandin metabolizing enzymes and serum PGE2 levels with vitamin D receptor and serum 25(OH)2D3 levels in breast a nd ovarian cancer. (PubMed id 22213326)1 Cordes T....Thill M. (2012)
    922. Cyclooxygenase-2 -765 G/C polymorphisms and susceptibi lity to hepatitis B-related liver cancer in Han Chinese population. (PubMed id 21800055)1 He J....He W. (2012)
    923. The expression of MAGE and SSX, and correlation of COX 2, VEGF, and survivin in colorectal cancer. (PubMed id 22287745)1 Choi J. and Chang H. (2012)
    924. The effects of cyclooxygenase-2 gene silencing by siRN A on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan- 2 human pancreatic cancer cells. (PubMed id 22200969)1 Zhong Y....Zan H. (2012)
    925. The influence of transforming growth factor-a, cycloox ygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved i n epithelial-mesenchymal transition on overall survival of patients with gastric cancer. (PubMed id 22582975)1 Fanelli M.F....Montagnini A.L. (2012)
    926. COX2 overexpression is a prognostic marker for Stage I II breast cancer. (PubMed id 21533532)1 Kim H.S....Noh D.Y. (2012)
    927. A novel cytotoxic T lymphocyte epitope analogue with e nhanced activity derived from cyclooxygenase-2. (PubMed id 22686557)1 Wu Y.H....Qi Y.M. (2012)
    928. Expression of COX-2 on Reed-Sternberg cells is an inde pendent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD. (PubMed id 22547578)1 Mestre F....Rodriguez J. (2012)
    929. Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development. (PubMed id 22376259)1 Kwagyan J....Ashktorab H. (2012)
    930. Expression of cyclooxygenase-2 (COX-2) in pituitary tu mours. (PubMed id 22460097)1 Sokol/owski G....Gol/kowski F. (2012)
    931. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chroni c periodontitis in a Chinese population. (PubMed id 22819245)1 Li G....Chow L.W. (2012)
    932. A common single-nucleotide polymorphism in cyclooxygen ase-2 disrupts microRNA-mediated regulation. (PubMed id 21822307)1 Moore A.E....Dixon D.A. (2012)
    933. Association of cyclooxygenase 2 single-nucleotide poly morphisms and hepatocellular carcinoma in Taiwan. (PubMed id 22242948)1 Chang W.S....Bau D.T. (2012)
    934. The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. (PubMed id 22331023)1 Gal/ecki P....Szemraj J. (2012)
    935. Cyclooxygenase-2 is a target of microRNA-16 in human h epatoma cells. (PubMed id 23226427)1 Agra Andrieu N....Martin-Sanz P. (2012)
    936. Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells. (PubMed id 22885178)1 Zhu Y....Lance P. (2012)
    937. Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. (PubMed id 23105117)1 Vazquez-Cedeira M. and Lazo P.A. (2012)
    938. Effects of Feiyanning Decoction, a compound traditiona l Chinese medicine, on iNOS and COX-2 expressions induced by tumor necrosis fact or-a in lung adenocarcinoma cell line. (PubMed id 22704420)1 Wang J.Y....Wang Q. (2012)
    939. PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population. (PubMed id 22173719)1 Daraei A....Mohamadhashem F. (2012)
    940. Lower cyclooxygenase-2 expression is associated with r ecurrence of solitary non-muscle invasive bladder carcinoma. (PubMed id 23126361)1 Tadin T....Jonjic N. (2012)
    941. Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-kB activation in TPA-induced breast cancer cells. (PubMed id 22740037)1 Park S.Y....Lee S.J. (2012)
    942. Heterogeneity of COX-2 and multidrug resistance betwee n primary tumors and regional lymph node metastases of gastric cancer. (PubMed id 23052170)1 Li Y....Wang D. (2012)
    943. Differential age- and disease-related effects on the e xpression of genes related to the arachidonic acid signaling pathway in schizoph renia. (PubMed id 22397921)1 Tang B....Thomas E.A. (2012)
    944. The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeu tic target. (PubMed id 22808264)1 Orlando U.D....Podesta E.J. (2012)
    945. Cyclooxygenase-2 (COX-2) up-regulation is a prognostic marker for poor clinical outcome of upper tract urothelial cancer. (PubMed id 22993369)1 Ke H.L....Bau D.T. (2012)
    946. Association between COX-2 rs2745557 polymorphism and p rostate cancer risk: a systematic review and meta-analysis. (PubMed id 22435969)1 Zhang H....Ma B. (2012)
    947. Cyclooxygenase-2 -765G>C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstruct ive pulmonary disease patients. (PubMed id 22100366)1 Lopez-Campos J.L....Arellano E. (2012)
    948. Polymorphisms in cycloxygenase-2 gene and breast cance r prognosis: association between PTGS2 haplotypes and histopathological features . (PubMed id 22037828)1 Festa-Vasconcellos J.S....Vianna-Jorge R. (2012)
    949. CFTR negatively regulates cyclooxygenase-2-PGE(2) posi tive feedback loop in inflammation. (PubMed id 21913191)1 Chen J....Chan H.C. (2012)
    950. Effects of estrogen on endothelial prostanoid producti on and cyclooxygenase-2 and heme oxygenase-1 expression. (PubMed id 22330859)1 Marcantoni E....Patrignani P. (2012)
    951. Synergistic association of PTGS2 and CYP2E1 genetic po lymorphisms with lung cancer risk in northeastern Chinese. (PubMed id 22761909)1 Guo S....Niu W. (2012)
    952. The DHEA metabolite 7b-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. (PubMed id 22342541)1 Sandra N....Olivier H. (2012)
    953. Cyclooxygenase-2 expression in proliferative Ki-67-pos itive breast cancers is associated with poor outcomes. (PubMed id 22286316)1 Park B.W....Lee K.S. (2012)
    954. Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. -765G>C PTGS2 polymorphism and NMSC risk. (PubMed id 22159575)1 Cocos R....Raicu F. (2012)
    955. Expression of cyclooxygenase-2 in invasive breast carc inomas and its prognostic impact. (PubMed id 22936450)1 Dhakal H.P....Nesland J.M. (2012)
    956. Cyclic AMP increases COX-2 expression via mitogen-acti vated kinase in human myometrial cells. (PubMed id 21854542)1 Chen L....Johnson M.R. (2012)
    957. Simultaneous modulation of COX-2, p300, Akt, and Apaf- 1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. (PubMed id 22335196)1 Wang J....Deng W. (2012)
    958. Astaxanthin attenuates the UVB-induced secretion of pr ostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 pho sphorylation in a ROS depletion-independent manner. (PubMed id 22626465)1 Terazawa S....Imokawa G. (2012)
    959. Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. (PubMed id 22735610)1 Morita Y....Yoneda T. (2012)
    960. Acyl chain-dependent effect of lysophosphatidylcholine on cyclooxygenase (COX)-2 expression in endothelial cells. (PubMed id 22901457)1 Brkic L....Frank S. (2012)
    961. DNA hypomethylation of the COX-2 gene promoter is asso ciated with up-regulation of its mRNA expression in eutopic endometrium of endom etriosis. (PubMed id 22608095)1 Wang D....Li T. (2012)
    962. AMP-activated protein kinase mediates T cell activatio n-induced expression of FasL and COX-2 via protein kinase C theta-dependent path way in human Jurkat T leukemia cells. (PubMed id 22330070)1 Lee J.Y....Kang I. (2012)
    963. siRNA-mediated knock-down of COX-2 in melanocytes supp resses melanogenesis. (PubMed id 22506937)1 Kim J.Y....Oh S.H. (2012)
    964. Correlation between spiral CT preoperative staging of pancreatic cancer and PTEN and COX-2 expression. (PubMed id 22389271)1 Chun-Ye Q....Ming G. (2012)
    965. Cytoskeletal architecture regulates cyclooxygenase-2 i n human endothelial cells: autocrine modulation by prostacyclin. (PubMed id 22495438)1 Eligini S....Colli S. (2012)
    966. Genetic polymorphism in cyclooxygenase-2 promoter affe cts hepatic inflammation and fibrosis in patients with chronic hepatitis C. (PubMed id 22863264)1 Miyashita M....Imawari M. (2012)
    967. Involvement of COX-2/PGE2 signalling in hypoxia-induce d angiogenic response in endothelial cells. (PubMed id 22050691)1 Zhao L....Wei X. (2012)
    968. Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase- 2 expression in macrophages: the potential role of oleanolic acid. (PubMed id 21681438)1 Graham V.S....Botham K.M. (2012)
    969. Regulation of IL-1b-induced cyclooxygenase-2 expressio n by interactions of Ab peptide, apolipoprotein E and nitric oxide in human neur oglioma. (PubMed id 22101739)1 Samy A.S. and Igwe O.J. (2012)
    970. Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism an d advanced-stage endometriosis in Korean women. (PubMed id 22587873)1 Kim H.Y....Lee B.S. (2012)
    971. Cyclooxygenase-2 expression in central giant cell lesi on of the jaws: an immunohistochemical study. (PubMed id 22042094)1 Nogueira R.L....Rabenhorst S.H. (2012)
    972. Inhibition of cyclooxygenase-2 and inducible nitric ox ide synthase by silymarin in proliferating mesenchymal stem cells: comparison wi th glutathione modifiers. (PubMed id 21710354)1 Ahmadi-Ashtiani H....Barkhordari E. (2012)
    973. Expression levels of cyclooxygenase-2, tumor necrosis factor-a and inducible NO synthase in placental tissue of normal and preeclampti c pregnancies. (PubMed id 22014124)1 Goksu Erol A.Y....Yildiz S.E. (2012)
    974. Glutathione promotes prostaglandin H synthase (cycloox ygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2 a. (PubMed id 22982857)1 Tsikas D....Stichtenoth D.O. (2012)
    975. Gene expression profile of coronary artery cells treat ed with nonsteroidal anti-inflammatory drugs reveals off-target effects. (PubMed id 22668799)7 Palayoor S.T....Coleman C.N. (2012)
    976. A randomized phase II of gemcitabine and sorafenib ver sus sorafenib alone in patients with metastatic pancreatic cancer. (PubMed id 21424698)1 El-Khoueiry A.B....Lenz H.J. (2012)
    977. Maximal standardized uptake value on FDG-PET is correl ated with cyclooxygenase-2 expression in patients with lung adenocarcinoma. (PubMed id 22206958)1 Shimizu K....Nakata M. (2012)
    978. Anti-inflammatory potential of an ethyl acetate fracti on isolated from Justicia gendarussa roots through inhibition of iNOS and COX-2 expression via NF-kB pathway. (PubMed id 22063737)1 Kumar K.S....Helen A. (2012)
    979. Notch2-induced COX-2 expression enhancing gastric canc er progression. (PubMed id 21976141)1 Tseng Y.C....Yeh T.S. (2012)
    980. Expression of ezrin, MMP-9, and COX-2 in 50 chordoma s pecimens: a clinical and immunohistochemical analysis. (PubMed id 22228328)1 Froehlich E.V....Leithner A. (2012)
    981. miR-137 is frequently down-regulated in glioblastoma a nd is a negative regulator of Cox-2. (PubMed id 22406049)1 Chen L....Jiang C. (2012)
    982. -765 G->C and -1195 A->G promoter variants of the cycl ooxygenase-2 gene decrease the risk for preeclampsia. (PubMed id 22224631)1 Gurdol F....Isbir T. (2012)
    983. The effect of HIV and HPV coinfection on cervical COX- 2 expression and systemic prostaglandin E2 levels. (PubMed id 22135046)1 Fitzgerald D.W....Dannenberg A.J. (2012)
    984. Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant associ ation of rs20417 with prostate cancer. (PubMed id 22782583)1 Zhang H.T....Li L. (2012)
    985. Sodium arsenite-induced abnormalities in expressions o f Caveolin-1, eNOS, IKKb, and COX-2 in SV-40 immortalized human uroepithelial ce lls and in urothelial carcinomas. (PubMed id 22824620)1 Liu X.P....Chai C.Y. (2012)
    986. Induction of cyclooxygenase (COX)-2 in human vaginal e pithelial cells in response to TLR ligands and TNF-a. (PubMed id 22235849)1 Joseph T....Doncel G.F. (2012)
    987. Galectin-1 promotes lung cancer progression and chemor esistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. (PubMed id 22696230)1 Chung L.Y....Sun K.H. (2012)
    988. IL1b-mediated Stromal COX-2 signaling mediates prolife ration and invasiveness of colonic epithelial cancer cells. (PubMed id 22884582)1 Zhu Y....Lance P. (2012)
    989. Cyclooxygenase-2-765G>C functional promoter polymor phism and its association with oral squamous cell carcinoma. (PubMed id 22887904)1 Lakshmi A....Kaiser J. (2012)
    990. Oxidases and oxygenases in regulation of neutrophil re dox pathways in Behcet's disease patients. (PubMed id 21699462)1 Melikoglu M.A....Aslan M. (2012)
    991. Epidermal growth factor-stimulated human cervical can cer cell growth is associated with EGFR and cyclin D1 activation, independent o f COX-2 expression levels. (PubMed id 21946890)1 Narayanan R....Narayanan B. (2012)
    992. Heparanase and cyclooxygenase-2 gene and protein expre ssions during progression of oral epithelial dysplasia to carcinoma. (PubMed id 22575501)1 Nagatsuka H....Nakajima M. (2012)
    993. Cyclooxygenase-2 enzyme induces the expression of the a-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer. (PubMed id 23275522)1 Sproviero D....Burchell J.M. (2012)
    994. Interleukin-17 and prostaglandin E2 are involved in fo rmation of an M2 macrophage-dominant microenvironment in lung cancer. (PubMed id 22534817)1 Liu L....You Z. (2012)
    995. No association of nineteen COX-2 gene variants to prec linical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study. (PubMed id 22551325)1 Lahteela K....Nikkari S.T. (2012)
    996. Linoleic acid increases monocyte chemotaxis and adhesi on to human aortic endothelial cells through protein kinase C- and cyclooxygenas e-2-dependent mechanisms. (PubMed id 21840193)1 Matesanz N....Powell L.A. (2012)
    997. Functional polymorphism of cyclooxygenase-2 gene (G-76 5C) in chronic obstructive pulmonary disease patients. (PubMed id 21655952)1 Pietras T....Gorski P. (2012)
    998. Progesterone acts via the nuclear glucocorticoid recep tor to suppress IL-1b-induced COX-2 expression in human term myometrial cells. (PubMed id 23209664)1 Lei K....Johnson M.R. (2012)
    999. Association of the -14C/G MET and the -765G/C COX-2 ge ne polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. (PubMed id 22416915)1 Sitarek P....Majsterek I. (2012)
    1000. A genetic variant in 3'-untranslated region of cycloox ygenases-2 gene is associated with risk of gastric cancer in a Chinese populatio n. (PubMed id 22385256)1 Li H....Shen H. (2012)
    1001. Prostaglandin EP1 receptor down-regulates expression o f cyclooxygenase-2 by facilitating its proteasomal degradation. (PubMed id 22474323)1 Haddad A....Barki-Harrington L. (2012)
    1002. Streptococcus pneumoniae-induced regulation of cycloox ygenase-2 in human lung tissue. (PubMed id 22441740)1 Szymanski K.V....Hocke A.C. (2012)
    1003. Overexpression of vasoactive intestinal peptide recept ors and cyclooxygenase-2 in human prostate cancer. Analysis of potential prognos tic relevance. (PubMed id 22763881)1 Fernandez-Martinez A.B....Sanchez-Chapado M. (2012)
    1004. Expression of COX-2 and E-cadherin in Tunisian patient s with colorectal adenocarcinoma. (PubMed id 22133296)1 Miladi-Abdennadher I....Mokdad-Gargouri R. (2012)
    1005. The value of cyclooxygenase-2 expression in differenti ating between early melanomas and histopathologically difficult types of benign human skin lesions. (PubMed id 22228276)1 Kuzbicki L./....Chwirot B.W. (2012)
    1006. The establishment of supramolecular immunobead real-ti me PCR and the identification of Cox-2 as a metastasis-related marker in colorec tal carcinoma. (PubMed id 22710400)1 Li Z.G....Ding Y.Q. (2012)
    1007. Clinicopathological significance of cyclooxygenase-2 a nd cell cycle-regulatory proteins expression in patients with esophageal squamou s cell carcinoma. (PubMed id 21762277)1 Huang J.X....Yu H. (2012)
    1008. Interaction between head and neck squamous cell carcin oma cells and fibroblasts in the biosynthesis of PGE2. (PubMed id 22308510)1 Alcolea S....Vila L. (2012)
    1009. Regulation of cyclooxygenase-2 expression by heat: a n ovel aspect of heat shock factor 1 function in human cells. (PubMed id 22347460)1 Rossi A....Santoro M.G. (2012)
    1010. The role of cyclooxygenase-2 in mechanical ventilation -induced lung injury. (PubMed id 22556158)1 Robertson J.A....Nonas S.A. (2012)
    1011. Effects of AFP-172 on COX-2-induced angiogenic activit ies on human umbilical vein endothelial cells. (PubMed id 22910791)7 Roh Y.J....Moon J.I. (2012)
    1012. Licofelone inhibits interleukin-18-induced pro-inflamm atory cytokine release and cellular proliferation in human mesangial cells. (PubMed id 22433003)1 Wu Y.J....Chen H. (2012)
    1013. Nuclear localization of COX-2 in relation to the expre ssion of stemness markers in urinary bladder cancer. (PubMed id 22577245)1 Thanan R....Kawanishi S. (2012)
    1014. Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma. (PubMed id 22553404)1 Al-Maghrabi J....Al-Ahwal M. (2012)
    1015. COX-2 mRNA is increased in oesophageal mucosal cells b y a proton pump inhibitor. (PubMed id 22758658)1 Mayne G.C....Hussey D.J. (2012)
    1016. Prognostic role of host cyclooxygenase and cytokine ge notypes in a Caucasian cohort of patients with gastric adenocarcinoma. (PubMed id 23029430)1 Garcia-Gonzalez M.A....Quintero E. (2012)
    1017. SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors. (PubMed id 22464751)1 Rausch S.M....Yang P. (2012)
    1018. Serum concentrations of cyclooxygenase-2 in patients w ith systemic sclerosis: association with lower frequency of pulmonary fibrosis. (PubMed id 21979415)1 Bassyouni I.H....Salem T.A. (2012)
    1019. Is the immunohistochemical expression of proliferation (Ki-67) and apoptosis (Bcl-2) markers and cyclooxigenase-2 (COX-2) related to c arcinogenesis in postmenopausal endometrial polyps? (PubMed id 23301386)1 Antunes A....Costa-Paiva L. (2012)
    1020. Noninvasive imaging identifies new roles for cyclooxyg enase-2 in choline and lipid metabolism of human breast cancer cells. (PubMed id 21953546)1 Shah T....Bhujwalla Z.M. (2012)
    1021. A local paracrine and endocrine network involving TGFb , Cox-2, ROS, and estrogen receptor b influences reactive stromal cell regulatio n of prostate cancer cell motility. (PubMed id 22593181)1 Grubisha M.J....Defranco D.B. (2012)
    1022. The expression of p53 and COX-2 in basal cell carcinom a, squamous cell carcinoma and actinic keratosis cases. (PubMed id 22627629)1 Karagece Yalcin U. and Seckin S. (2012)
    1023. Involvement of store-operated calcium signaling in EGF -mediated COX-2 gene activation in cancer cells. (PubMed id 21924350)1 Wang J.Y....Chang W.C. (2012)
    1024. EC-SOD induces apoptosis through COX-2 and galectin-7 in the epidermis. (PubMed id 22251572)1 Lee J.S....Kim T.Y. (2012)
    1025. Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans. (PubMed id 22859522)1 Yu G....Pardo A. (2012)
    1026. Purification and characterization of the recombinant h uman prostaglandin H synthase-2 expressed in Pichia pastoris. (PubMed id 22504626)1 Kukk K....Samel N. (2012)
    1027. Cyclooxygenase-2, not microsomal prostaglandin E synth ase-1, is the mechanism for interleukin-1b-induced prostaglandin E2 production a nd inhibition of insulin secretion in pancreatic islets. (PubMed id 22822059)1 Parazzoli S....Robertson R.P. (2012)
    1028. Signal transduction pathways (MAPKs, NF-kB, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspi rin intolerance. (PubMed id 23240010)1 Garcia-Garcia F.J....Picado C. (2012)
    1029. Epithelial to mesenchymal transition in cutaneous squa mous cell carcinoma is correlated with COX-2 expression but not with the presenc e of stromal macrophages or CD10-expressing cells. (PubMed id 22460857)1 Jang T.J. (2012)
    1030. COX/PGE(2) axis critically regulates effects of LPS on eosinophilia-associated cytokine production in nasal polyps. (PubMed id 22805469)1 Higaki T....Nishizaki K. (2012)
    1031. The androgen metabolite, 5a-androstane-3b,17b-diol, de creases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 exp ression, and P-glycoprotein expression in male human brain microvascular endothe lial cells. (PubMed id 23117931)1 Zuloaga K.L....Handa R.J. (2012)
    1032. Association of folate intake, dietary habits, smoking and COX-2 promotor -765G>C polymorphism with K-ras mutation in patients with colorectal cancer. (PubMed id 22929917)1 Kamal M.M....Fawzy M.M. (2012)
    1033. MicroRNA-199a* regulates the expression of cyclooxygen ase-2 in human chondrocytes. (PubMed id 22294637)1 Akhtar N. and Haqqi T.M. (2012)
    1034. Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis. (PubMed id 23250779)1 Xu C....Liu Q. (2012)
    1035. The P2Y2/Src/p38/COX-2 pathway is involved in the resi stance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells . (PubMed id 22521508)1 Limami Y....Liagre B. (2012)
    1036. Clinical relevance of cyclooxygenase-2 and matrix meta lloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue. (PubMed id 22527932)1 Mohammad M.A....Abdel-Wahab A.H. (2012)
    1037. Platelet lysate suppresses the expression of lipocalin -type prostaglandin D2 synthase that positively controls adipogenic differentiat ion of human mesenchymal stromal cells. (PubMed id 22698646)1 Lange C....Scheja L. (2012)
    1038. Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E_2 production in human endometriotic stromal cells in spheroid culture. (PubMed id 22130322)1 Yamanaka K....Kitawaki J. (2012)
    1039. Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection. (PubMed id 22072783)1 Fang J....Zhu Y. (2012)
    1040. Inflammatory effect of advanced glycation end products on human meniscal cells from osteoarthritic knees. (PubMed id 21842276)1 Hiraiwa H....Ishiguro N. (2011)
    1041. Systematic evaluation of genetic variants in three bi ological pathways on patient survival in low-stage non-small cell lung cancer. (PubMed id 21792076)1 Pankratz V.S....Yang P. (2011)
    1042. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. (PubMed id 20950588)1 Yoshikawa K....Shimada A. (2011)
    1043. Peritoneal fluid of patients with endometriosis promo tes proliferation of endometrial stromal cells and induces COX-2 expression. (PubMed id 21145050)1 Liu Y....Yu C. (2011)
    1044. Increased I95- and I96-desaturase, cyclooxygenase-2, an d lipoxygenase-5 expression and activity are associated with fatty acid and eic osanoid changes in cystic fibrosis. (PubMed id 21605700)1 Njoroge S.W....Laposata M. (2011)
    1045. Associations between variants in the cyclooxygenase 2 enzyme gene (PTGS2) and development of benign prostate enlargement. (PubMed id 21481131)1 St Sauver J.L....Jacobsen S.J. (2011)
    1046. Interaction between COX-2 G-765C and smoking in relat ion to coronary artery disease in a Chinese Uighur population. (PubMed id 21091235)1 Xie X....Liu F. (2011)
    1047. Selective cyclooxygenase-2 (COX-2) inhibitors and bre ast cancer risk. (PubMed id 20724158)7 Ashok V....Terry P.D. (2011)
    1048. High-throughput screen of protein expression levels in duced by cyclooxygenase-2 during influenza a virus infection. (PubMed id 21354125)1 Liu L....Zhu Y. (2011)
    1049. A comparative immunohistochemical analysis of COX-2, p53, and Ki-67 expression in keratocystic odontogenic tumors. (PubMed id 21215666)1 Mendes R.A....van der Waal I. (2011)
    1050. Expression of HuR, COX-2, and survivin in lung cancer s; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. (PubMed id 21572400)1 Kim G.Y....Kim Y.W. (2011)
    1051. All-trans- and 9-cis-retinoic acids activate the huma n cyclooxynase-2 gene: a role for DR1 as RARE or RXRE. (PubMed id 20376700)1 Han K....Lim H.J. (2011)
    1052. Nuclear co-localization and functional interaction of COX-2 and HIF-1a characterize bone metastasis of human breast carcinoma. (PubMed id 21069452)1 Maroni P....Desiderio M.A. (2011)
    1053. Involvement of P2Y6 receptor in p38 MAPK-mediated COX -2 expression in response to UVB irradiation of human keratinocytes. (PubMed id 21388279)1 Takai E....Kojima S. (2011)
    1054. Cyclooxygenase-2 (COX-2) expression in solid pseudopa pillary tumor of the pancreas: a pilot study. (PubMed id 21160376)1 Kang C.M....Lee W.J. (2011)
    1055. [Cyclooxygenase-2 overexpression and vascular endothel ial growth factor expression in pharyngeal tissue of patients with OSAHS correla tes with angiogenesis]. (PubMed id 21845875)1 Zeng H.H....Wang L.X. (2011)
    1056. Lack of association of the cyclooxygenase 8473 T>C polymorphism with lung cancer: evidence from 9841 subjects. (PubMed id 22292629)1 Pan F....Zhang Y. (2011)
    1057. Cyclooxygenase-2 confers growth advantage to syngenei c pancreatic cancer cells. (PubMed id 21343834)1 Takahashi H....Eibl G. (2011)
    1058. Cyclooxygenase-2 gene and epithelial ovarian carcinom a risk. (PubMed id 21107726)1 Agachan Cakmakoglu B....Attar E. (2011)
    1059. Early proliferation alteration and differential gene expression in human periodontal ligament cells subjected to cyclic tensile stre ss. (PubMed id 20934684)1 Wang Y....Zhao Z. (2011)
    1060. Changes in extracellular matrix composition regulate cyclooxygenase-2 expression in human mesangial cells. (PubMed id 21209362)1 Alique M....RodrA-guez-Puyol D. (2011)
    1061. Biosynthesis of hemiketal eicosanoids by cross-over o f the 5-lipoxygenase and cyclooxygenase-2 pathways. (PubMed id 21482803)1 Griesser M....Schneider C. (2011)
    1062. Cycloxygenase-2 is essential for the survival and prol iferation of gastric cancer cells. (PubMed id 21830126)1 Ma D....Yang H. (2011)
    1063. [Expressions and significance of COX-2 and P-gp in hum an hepatocellular carcinoma tissues]. (PubMed id 22409848)1 Li B....Gong J.P. (2011)
    1064. Molecular evidence of a (pro)renin/ (pro)renin recept or system in human intrauterine tissues in pregnancy and its association with P GHS-2. (PubMed id 20702505)1 Pringle K.G....Lumbers E.R. (2011)
    1065. COX2 expression in prognosis and in prediction to end ocrine therapy in early breast cancer patients. (PubMed id 20358279)1 van Nes J.G....Bartlett J.M. (2011)
    1066. [Effects of LPS-induced inflammation on differentiati on of orbital pre-adipocytes in thyroid-associated ophthalmopathy]. (PubMed id 21426847)1 Yi W.S. and Xu X.L. (2011)
    1067. COX-2 expression predicts worse breast cancer prognos is and does not modify the association with aspirin. (PubMed id 21728052)1 Holmes M.D....Tamimi R.M. (2011)
    1068. [Mechanism of apoptosis of NB4 cells induced by arsen ic trioxide and cyclooxygenase-2 expression]. (PubMed id 21729542)1 Qin D.B....Wang S.Q. (2011)
    1069. Role of cyclooxygenase-2 gene polymorphisms in pancre atic carcinogenesis. (PubMed id 22039326)1 Talar-Wojnarowska R....Malecka-Panas E. (2011)
    1070. Food contaminant acrylamide increases expression of C ox-2 and nitric oxide synthase in breast epithelial cells. (PubMed id 20713430)1 Lyn-Cook L.E....Hammons G.J. (2011)
    1071. Induction of cyclooxygenase-2 expression by hepatitis B virus depends on demethylation-associated recruitment of transcription facto rs to the promoter. (PubMed id 21401943)1 Yue X....Zhu Y. (2011)
    1072. Cyclic mechanical stretch downregulates IL-1I^-induced COX-2 expression and PGE(2) production in rheumatoid arthritis fibroblast-like synoviocytes. (PubMed id 20887233)1 Wang P....Yang L. (2011)
    1073. Expression of VEGF, VEGFR, EGFR, COX-2 and MVD in cer vical carcinoma, in relation with the response to radio-chemotherapy. (PubMed id 21424032)1 Nagy V.M....BA8lA8cescu O. (2011)
    1074. Immunohistochemical expression of cyclooxygenage-2 in melanocytic skin lesions. (PubMed id 21182498)1 Minami S....Namiki T.S. (2011)
    1075. Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. (PubMed id 22203921)1 Balan R....Caruntu I.D. (2011)
    1076. Apoptosis inducing effect of plumbagin on colonic can cer cells depends on expression of COX-2. (PubMed id 21559086)1 Subramaniya B.R....Sivasitambaram N.D. (2011)
    1077. Cyclooxygenase-2 is an independent predictor of poor prognosis in uterine leiomyosarcomas. (PubMed id 21412163)1 Lee C.H....Song Y.S. (2011)
    1078. Cyclooxygenase-2 polymorphisms and pancreatic cancer s usceptibility. (PubMed id 21705955)1 Ozhan G....Daly A.K. (2011)
    1079. The expression of both peroxisome proliferator-activa ted receptor delta and cyclooxygenase-2 in tissues is associated with poor prog nosis in colorectal cancer patients. (PubMed id 20824502)1 Yoshinaga M....Muto Y. (2011)
    1080. Upregulated expression of Toll-like receptor 4 in per ipheral blood of ischaemic stroke patients correlates with cyclooxygenase 2 exp ression. (PubMed id 21236709)1 Ferronato S....Mazzucco S. (2011)
    1081. COX2 expression predicts resistance to chemoradiother apy in esophageal squamous cell carcinoma. (PubMed id 21437756)1 Akutsu Y....Matsubara H. (2011)
    1082. Human brain endothelial cell-derived COX-2 facilitates extravasation of breast cancer cells across the blood-brain barrier. (PubMed id 22199296)1 Lee K.Y....Kim H.J. (2011)
    1083. Nitroarachidonic acid, a novel peroxidase inhibitor o f prostaglandin endoperoxide H synthases 1 and 2. (PubMed id 21266582)1 Trostchansky A....Rubbo H. (2011)
    1084. An imbalance of COX level is not related to placental abruption. (PubMed id 21561892)1 Avagliano L....Bulfamante G.P. (2011)
    1085. Cyclooxygenase-2 up-regulates vascular endothelial gr owth factor via a protein kinase C pathway in non-small cell lung cancer. (PubMed id 21219643)1 Luo H....Zhong B. (2011)
    1086. Interleukin-1I^ induces cyclooxygenase-2 expression an d promotes the invasive ability of human mesenchymal stem cells derived from ov arian endometrioma. (PubMed id 21762900)1 Kao A.P....Tsai E.M. (2011)
    1087. Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cycloox ygenase-2. (PubMed id 21867538)1 ValcA!rcel M....Vidal-Vanaclocha F. (2011)
    1088. No influence of PTGS2 polymorphisms on response and r emission to antidepressants in major depression. (PubMed id 21168919)1 Serretti A....Mendlewicz J. (2011)
    1089. Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon cancer. (PubMed id 21830391)1 Cha H.J....Park J.W. (2011)
    1090. Cyclooxygenase-2 in oncogenesis. (PubMed id 21187081)1 Rizzo M.T. (2011)
    1091. Clinicopathologic implications of the epidermal growt h factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. (PubMed id 21270615)1 Giordano G....Merisio C. (2011)
    1092. HT-29 colorectal cancer cells undergoing apoptosis ov erexpress COX-2 to delay ursolic acid-induced cell death. (PubMed id 21251952)1 Limami Y....Simon A. (2011)
    1093. Increased COX-2 expression in human vaginal epithelial cells exposed to nonoxynol-9, a vaginal contraceptive microbicide that failed t o protect women from HIV-1 infection. (PubMed id 21241401)7 Zalenskaya I.A....Doncel G.F. (2011)
    1094. Correlation between COX-2 and APC expression in left versus right-sided human colon cancer. (PubMed id 21737640)1 Nasir A....Coppola D. (2011)
    1095. Transgenic mice expressing cyclooxygenase-2 in hepato cytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenes is. (PubMed id 21356386)1 Llorente Izquierdo C....MartA-n-Sanz P. (2011)
    1096. [Expression and clinical significance of COX-2 and BCL -2 in distal transitional mucosa adjacent to rectal carcinoma]. (PubMed id 21713707)1 Zhou D.F....Cui L. (2011)
    1097. Cisplatin decreases renal cyclooxygenase-2 expression and activity in rats. (PubMed id 21272267)7 Tusgaard B....Frokiaer J. (2011)
    1098. Different expression of cyclooxygenase-2 (COX-2) in se lected nonmelanocytic human cutaneous lesions. (PubMed id 22038215)1 Kuzbicki L./....Chwirot B.W. (2011)
    1099. Immunohistochemical COX-2 overexpression correlates w ith HER-2/neu overexpression in invasive breast carcinomas: a pilot study. (PubMed id 21371829)1 A8iriA9 I.M....KapucuoA9lu F.N. (2011)
    1100. Gallbladder cancer predisposition: a multigenic appro ach to DNA-repair, apoptotic and inflammatory pathway genes. (PubMed id 21283657)1 Srivastava K....Mittal B. (2011)
    1101. Pivotal role of protein kinase Cdelta in angiotensin II-induced endothelial cyclooxygenase-2 expression: a link to vascular inflamma tion. (PubMed id 21311042)1 Wong S.L....Huang Y. (2011)
    1102. Prognostic significance of expression of VEGF and Cox -2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 a nd EGFR. (PubMed id 21031415)1 Kim T.J....Kang C.S. (2011)
    1103. Interaction of cyclooxygenase-2 promoter polymorphism s with Helicobacter pylori infection and risk of gastric cancer. (PubMed id 21538574)1 Zhang X....Miao X. (2011)
    1104. Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cycloo xygenase 2 and prostaglandin D2 synthase. (PubMed id 21683347)1 Welter H....Mayerhofer A. (2011)
    1105. IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression thr ough JAK1 and STAT6. (PubMed id 21277633)1 Cho W....Choe J. (2011)
    1106. Methylation status and overexpression of COX-2 in Tun isian patients with ductal invasive breast carcinoma. (PubMed id 21153458)1 Karray-Chouayekh S....Mokdad-Gargouri R. (2011)
    1107. EGFR and COX-2 protein expression in non-small cell l ung cancer and the correlation with clinical features. (PubMed id 21385353)1 Li F....Wang J. (2011)
    1108. Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer. (PubMed id 19836060)1 Bin W....Honglin G. (2011)
    1109. [The expression and clinical significance of HIF-1I+, COX-2 and E-cadherin in patients with lung adenocarcinoma]. (PubMed id 21426663)1 Gu S. and Qin J. (2011)
    1110. [Cyclooxigenase-2 levels are increased in the lung tis sue and bronchial tumors of patients with chronic obstructive pulmonary disease] . (PubMed id 21798652)1 Roca-Ferrer J....Picado C. (2011)
    1111. Dihydrotestosterone attenuates hypoxia inducible fact or-1I+ and cyclooxygenase-2 in cerebral arteries during hypoxia or hypoxia with glucose deprivation. (PubMed id 21856910)1 Zuloaga K.L. and Gonzales R.J. (2011)
    1112. The interplay between indoleamine 2,3-dioxygenase 1 ( IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer. (PubMed id 21517752)1 Cesario A....Rutella S. (2011)
    1113. [Expressions of CD4+ CD25(high) regulatory T cells, TG F-beta 1 and COX-2 in the peripheral blood of prostate cancer patients]. (PubMed id 22049790)1 Xia T.L....Li L.Y. (2011)
    1114. Targeting KSHV/HHV-8 latency with COX-2 selective inhi bitor nimesulide: a potential chemotherapeutic modality for primary effusion lym phoma. (PubMed id 21980345)1 Paul A.G....Chandran B. (2011)
    1115. Correlations of hypoxia-inducible factor-1I+/hypoxia-i nducible factor-2I+ expression with angiogenesis factors expression and prognosi s in non-small cell lung cancer. (PubMed id 21362301)1 Wu X.H....Yuan K. (2011)
    1116. Human cyclooxygenase-2 is a sequence homodimer that f unctions as a conformational heterodimer. (PubMed id 21467029)1 Dong L....Smith W.L. (2011)
    1117. Cyclooxygenase-2 expression in lung cancer cells eval uated by immunocytochemistry. (PubMed id 21319320)1 Koch A....SAPrenson S. (2011)
    1118. Overproduction of cyclo-oxygenase-2 (COX-2) is involv ed in the resistance to apoptosis in vascular smooth muscle cells from diabetic patients: a link between inflammation and apoptosis. (PubMed id 20957341)1 Redondo S....Tejerina T. (2011)
    1119. Up