PTGS2 Gene

Aliases
for PTGS2 gene

Previous GC identifers: GC01M184166 GC01M182068 GC01M183160 GC01M183879 GC01M183372 GC01M184907 GC01M157875

Summaries
for PTGS2 gene

Genomic Views
for PTGS2 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_004487.19  

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTGS2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGS2

PTGS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M186640:  view genomic region     (about GC identifiers)

Proteins
for PTGS2 gene

1 PDB 3D structure from and Proteopedia for PTGS2:

1V0X (3D)    

Explore the universe of human proteins at neXtProt for PTGS2: NX_P35354

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PTGS2 OriGene Custom Protein Services for PTGS2
	GenScript Custom Purified and Recombinant Proteins Services for PTGS2
	Novus Biologicals PTGS2 Proteins Novus Biologicals PTGS2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTGS2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGS2
	R&D Systems Antibodies for PTGS2 (COX-2)
	Cell Signaling Technology (CST) Antibodies for PTGS2  (COX-2)
	OriGene Antibodies (see all 3): PTGS2 OriGene Custom Antibody Services for PTGS2
	GenScript Custom Superior Antibodies Services for PTGS2
	Novus Biologicals PTGS2 Antibodies
	Abcam antibodies for PTGS2
	Uscn Antibodies for PTGS2
	ThermoFisher Antibodies for PTGS2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for PTGS2 (COX-2)         (see all)
	GenScript Custom Assay Services for PTGS2
	Cell Signaling Technology (CST) Sandwich ELISA Kits for PTGS2 (COX-2)
	Enzo Life Sciences assays for PTGS2
	Uscn ELISAs and CLIAs for PTGS2

Protein Domains /
Families
for PTGS2 gene

ProtoNet protein and cluster: P35354

Function
for PTGS2 gene

     Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

15/25 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Ptgs2)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PTGS2

miRNA Products:		miRTarBase miRNAs that target PTGS2: hsa-mir-101 (MIRT004297), hsa-let-7b (MIRT001603), hsa-mir-16 (MIRT001426), hsa-mir-26b (MIRT004659)
		OriGene 3'-UTR Clone: PTGS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGS2
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGS2 (see all 23):
		hsa-miR-4291 hsa-miR-576-3p hsa-miR-624* hsa-miR-1297 hsa-miR-144 hsa-miR-629* hsa-miR-558 hsa-miR-1827
		SwitchGear 3'UTR luciferase reporter plasmid: PTGS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGS2 (see all 7) OriGene shRNA RFP: PTGS2 OriGene siRNA: PTGS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGS2
		Sirion Biotech Custom design and validation of potent shRNA sequences against PTGS2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PTGS2
			Sirion Biotech Customized adenovirus for overexpression of PTGS2  Sirion Biotech Customized adenovirus for potent knockdown of PTGS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTGS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTGS2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTGS2 (NM_000963)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTGS2
		Search LifeMap BioReagents cell lines for PTGS2
		Sirion Biotech Customized stable knockdown cell line services for PTGS2  Sirion Biotech Customized inducible knockdown cell line services for PTGS2 Sirion Biotech Customized stable overexpressing cell line services for PTGS2 Sirion Biotech Customized inducible overexpressing cell line services for PTGS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

Pathways & Interactions
for PTGS2 gene

	Super-pathway	contained gene-specific pathways
1	Arachidonic acid metabolism	Arachidonic acid metabolism 1.00 HETE and HPETE biosynthesis and metabolism 0.39 Arachidonic acid metabolism 0.42 Eicosanoid Synthesis 0.31 HETE and HPETE biosynthesis and metabolism 0.39
2	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 1.00 Prostaglandin 2 biosynthesis and metabolism FM 0.44 prostanoid biosynthesis 0.50 Prostaglandin 2 biosynthesis and metabolism FM 0.44
3	PEDF Induced Signaling	MIF Mediated Glucocorticoid Regulation 0.73 all-trans-Retinoic Acid Signaling in Brain 0.59 MIF Regulation of Innate Immune Cells 0.71 Endothelin-1 Signaling Pathway 0.44
4	Metabolism	Metabolism 1.00 Metabolism of lipids and lipoproteins 0.34 Metabolic pathways 0.38
5	Immune response_IL-1 signaling pathway	Immune response_IL-1 signaling pathway 1.00 Immune response IL-1 signaling pathway 0.98

5/9 EMD Millipore Pathways for PTGS2

	Development HGF signaling pathway
	Prostaglandin 2 biosynthesis and metabolism FM
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	HETE and HPETE biosynthesis and metabolism

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTGS2

	MIF Regulation of Innate Immune Cells
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	HGF Pathway
	Endothelin-1 Signaling Pathway
	Colorectal Cancer Metastasis

3 Cell Signaling Technology (CST) Pathways for PTGS2

	Angiogenesis
	Neuroscience
	NF-kappaB Signaling

5/10 GeneGo (Thomson Reuters) Pathways for PTGS2

	HETE and HPETE biosynthesis and metabolism
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	Development VEGF signaling via VEGFR2 - generic cascades
	Transcription PPAR Pathway

5/11 BioSystems Pathways for PTGS2

	Eicosanoid Synthesis
	Integrated Pancreatic Cancer Pathway
	Prostaglandin Synthesis and Regulation
	Integrated Pancreatic Cancer Pathway
	Selenium Pathway

5        Reactome Pathways for PTGS2

	Metabolism
	Arachidonic acid metabolism
	Synthesis of 15-eicosatetraenoic acid derivatives
	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
	Metabolism of lipids and lipoproteins

4 PharmGKB Pathways for PTGS2

	Acetaminophen Pathway, Pharmacokinetics
	Celecoxib Pathway, Pharmacodynamics
	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
	Pathway_PA165986194 -need delete

5/6         Kegg Pathways  (Kegg details for PTGS2)

	Arachidonic acid metabolism
	Metabolic pathways
	VEGF signaling pathway
	Leishmaniasis
	Pathways in cancer

PTGS2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTGS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/79 Interacting proteins for PTGS2 (P35354³ ENSP00000356438⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

Gene Ontology (GO): 5/63 biological process terms (GO ID links to tree view) (see all 63):    About this table

Drugs & Compounds
for PTGS2 gene

Transcripts
for PTGS2 gene

Expression
for PTGS2 gene

PTGS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTTCCTTT

About this image

PTGS2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryAntral FollicleCumulus Cells			Ovary
	OvaryAntral FollicleMural Granulosa Cells			Ovary
	HeartMyocardiumCardiac Fibroblasts			Epicardium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	PureStem™ progenitor E44 (Embryonic Progenitor Cell)
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
	Fetal cardiomyocytes (20 weeks) (Primary Cell)			Heart, Myocardium

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTGS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

Orthologs
for PTGS2 gene

Paralogs
for PTGS2 gene

Paralogs for PTGS2 gene

PTGS1²  

2 SIMAP similar genes for PTGS2 using alignment to 3 protein entries:     PGH2_HUMAN (see all proteins):

COX-2    PTGS1

PTGS2 for paralogs           About GeneDecksing

Genomic Variants
for PTGS2 gene

10/474 NCBI SNPs in PTGS2 are shown (see all 474)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs46483101,2	C,F,H	--	157875293(-)	cctctA/Gtcctt	1	--	ds5001		22		NS EA NA	2134
rs46483091,2	C,F	--	157875382(-)	GGGGGC/GACAAA	1	--	ds5001		1		NS	180
rs46483071,2	C,F,A,H	--	157875471(-)	GATGGA/AA        /C/GCAAACA	1	--	ds5001		21		NS EA NA WA	2180
rs46483051,2	C,F	--	157875590(-)	ATGAAA/-TGGTT	1	--	ds5001		1		NS	180
rs46483041,2	C,F,H	--	157875621(-)	CCTACC/TTATTC	1	--	ds5001		14		NS EA NA WA	1514
rs1917887111,2	C	--	157875925(+)	TACAAG/TCATAT	1	--	ut31		0	--	--	--	--
rs46483031,2	C,F,H	--	157875966(-)	TTTTAC/TGTTTA	1	--	ut31 ese3		10		NS EA NA	1344
rs6894671,2	C,F	--	157876041(-)	AAAATT/GTTCTT	1	--	ut31		5		NS NA	388
rs1832016501,2	C	--	157876086(+)	TCAGCA/GTTTGA	1	--	ut31		0	--	--	--	--
rs46483011,2	C,F,H	--	157876126(-)	ATATTC/TTGTGT	1	--	ut31		14		NS EA NA WA	1822

HapMap Linkage Disequilibrium report for PTGS2 (186640923 - 186649559 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for PTGS2: --
Human Gene Mutation Database (HGMD): PTGS2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTGS2

DNA2.0 Custom Variant and Variant Library Synthesis for PTGS2

Disorders / Diseases
for PTGS2 gene

20/359 diseases for PTGS2

10/98 Novoseek disease relationships for PTGS2 gene (see all 98)    About this table

Publications
for PTGS2 gene

PubMed articles for PTGS2 gene, integrated from 9 sources (see all 6603) (see top 10): (articles sorted by number of sources associating them with PTGS2)

Utopia: connect your pdf to the dynamic world of online information

1. Human cyclooxygenase-2 cDNA. (PubMed id 1380156)^{1, 2, 3} Hla T. and Neilson K. (1992)
2. Characterization of the human gene (PTGS2) encoding prostaglandin- endoperoxide synthase 2. (PubMed id 8181472)^{1, 2, 9} Kosaka T.... Tanabe T. (1994)
3. Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. (PubMed id 15173859)^{1, 4, 9} Cox D.G....Moreno V. (2004)
4. A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. (PubMed id 15777967)^{1, 4, 9} Hu Z....Shen H. (2005)
5. COX-2 gene promoter haplotypes and prostate cancer risk. (PubMed id 14754878)^{1, 4, 9} Panguluri R.C....Kittles R.A. (2004)
6. Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis. (PubMed id 17322116)^{1, 7, 9} Weinheimer E.M....Trappe T.A. (2007)
7. The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease. (PubMed id 16309832)^{1, 4, 9} Abdullah L....Mullan M. (2006)
8. Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. (PubMed id 17181859)^{1, 7, 9} Shen J....Santella R.M. (2006)
9. Polymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancer. (PubMed id 15596291)^{1, 4, 9} Kang S....Lee H.P. (2005)
10. Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption. (PubMed id 15550453)^{1, 4, 9} Siezen C.L....Kampman E. (2005)
11. Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease. (PubMed id 16273614)^{1, 4, 9} Cox D.G....Canzian F. (2005)
12. n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells. (PubMed id 17459764)^{1, 7, 9} Chene G....Pipy B. (2007)
13. Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. (PubMed id 17175104)^{1, 7, 9} Lee Y.S....Dionne R.A. (2007)
14. Glycosylation regulates turnover of cyclooxygenase-2. (PubMed id 17113084)^{1, 2, 9} Sevigny M.B....Hughes-Fulford M. (2006)
15. PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. (PubMed id 15767339)^{1, 4, 9} Ulrich C.M....Bigler J. (2005)
16. Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism. (PubMed id 15930344)^{1, 4, 9} Brosens L.A....Goggins M. (2005)
17. Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (PubMed id 14749922)^{1, 4, 9} Choi J.H....Shin H.D. (2004)
18. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. (PubMed id 15138244)^{1, 4, 9} Cipollone F....Mezzetti A. (2004)
19. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. (PubMed id 14604894)^{1, 4, 9} Campa D....Canzian F. (2004)
20. Testing for colon neoplasia susceptibility variants at the human COX2 locus. (PubMed id 11309440)^{1, 4, 9} Wiesner G.L....Markowitz S.D. (2001)
21. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. (PubMed id 8473346)^{1, 2, 9} Jones D.A....Prescott S.M. (1993)
22. Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. (PubMed id 17560944)^{1, 7} Chae S.W....Choi H.J. (2007)
23. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
24. Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. (PubMed id 16361272)^{1, 4} Sakoda L.C....Hsing A.W. (2006)
25. Polymorphisms associated with asthma are inversely related to glioblastoma multiforme. (PubMed id 16024651)^{1, 4} Schwartzbaum J....Feychting M. (2005)
26. Inducible nitric oxide synthase binds, S-nitrosylates , and activates cyclooxygenase-2. (PubMed id 16373578)^{1, 2} Kim S.F....Snyder S.H. (2005)
27. Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. (PubMed id 16205694)^{1, 4} Ali I.U....Greenwald P. (2005)
28. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. (PubMed id 16083713)^{1, 4} Zhang X....Lin D. (2005)
29. Cyclooxygenase-1 haplotype modulates platelet response to aspirin. (PubMed id 16150050)^{1, 4} Maree A.O....Fitzgerald D.J. (2005)
30. A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. (PubMed id 16181776)^{1, 4} Wei J. and Hemmings G.P. (2005)
31. Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. (PubMed id 15150618)^{1, 4} Koh W.P....Yu M.C. (2004)
32. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
33. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)^{1, 4} Iwai N....Shioji K. (2004)
34. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)^{1, 2} Goodman J.E.... Harris C.C. (2004)
35. A functional polymorphism in the promoter region of the cyclooxygenase-2 gene is not associated with asthma and atopy in an Australian population. (PubMed id 15544595)^{1, 4} Shi J....Kedda M.A. (2004)
36. Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians. (PubMed id 12920574)^{1, 4} Konheim Y.L. and Wolford J.K. (2003)
37. Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. (PubMed id 12433707)^{1, 4} Lin H.J....Smith W.L. (2002)
38. Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. (PubMed id 12377741)^{1, 4} Papafili A....Laurent G.J. (2002)
39. Genotype Frequencies of Cyclooxygenease 2 (COX2) Rare Polymorphisms for Japanese with and without Colorectal Cancer. (PubMed id 12718655)^{1, 4} Hamajima N....Tajima K. (2001)
40. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. (PubMed id 7947975)^{1, 2} Barnett J.... Freire J. (1994)
41. Structure of the human cyclo-oxygenase-2 gene. (PubMed id 7945196)^{1, 2} Appleby S.B.... Hla T. (1994)
42. Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. (PubMed id 12209745)^{1, 9} Kim Y.B....Kim B.S. (2002)
43. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. (PubMed id 11959891)^{1, 9} Song X....Chen C.S. (2002)
44. Cyclooxygenase-2 (COX-2) negatively regulates express ion of epidermal growth factor receptor and causes resistance to gefitinib in C OX-2-overexpressing cancer cells. (PubMed id 19671676)^{1, 9} Kim Y.M....Pyo H. (2009)
45. Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. (PubMed id 16632868)^{1, 9} Tong M....Tai H.H. (2006)
46. Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. (PubMed id 11891209)^{1, 9} Niki T....Hirohashi S. (2002)
47. [VEGF, COX-2 and MVD in lesions of patients with condyloma acuminatum] (PubMed id 19462903)^{1, 9} Liu T. and Zhang H.H. (2009)
48. [Effect of hypoxia and IL-1beta on COX-2 expression and PGE2 release in human nasal epithelia] (PubMed id 19452719)^{1, 9} Wang Z....Liu Y. (2009)
49. [Effect of lipopolysaccharide on cyclooxygenase-2 exp ression and prostaglandin E2 release in human nasal epithelia] (PubMed id 18727513)^{1, 9} Wang Z....Yang Q. (2008)
50. Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. (PubMed id 18230181)^{1, 9} Kawasaki T....Ogino S. (2008)
51. Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. (PubMed id 18671849)^{1, 9} Zhu Y.M....Woll P.J. (2008)
52. Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. (PubMed id 15921850)^{1, 9} Cressey R....Leartprasertsuke N. (2006)
53. Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. (PubMed id 15608668)^{1, 9} Corcoran C.A....Sheikh M.S. (2005)
54. Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. (PubMed id 15968728)^{1, 9} Zhi Y.H....Guo R.X. (2005)
55. Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. (PubMed id 15156159)^{1, 9} Murata H....Hori M. (2004)
56. Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. (PubMed id 12767510)^{1, 9} Yu H.G....Schmitz F. (2003)
57. Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma. (PubMed id 14532971)^{1, 9} Leung W.K....Sung J.J. (2003)
58. Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. (PubMed id 11078056)^{7, 9} Fosslien E. (2000)
59. Expression and prognostic significance of Cox-2 and p -53 in Hodgkin lymphomas: a retrospective study. (PubMed id 20346139)^{1, 9} Barisik N.O....Tecimer T. (2010)
60. Cyclooxygenase-2 expression in non-Hodgkin's lymphomas. (PubMed id 17325901)^{1, 9} Paydas S....Seydaoglu G. (2007)
61. Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner. (PubMed id 17635918)^{1, 9} Jang B.C....Suh S.I. (2007)
62. Site-specific proteolysis of cyclooxygenase-2: a putative step in inflammatory prostaglandin E(2) biosynthesis. (PubMed id 17177291)^{1, 9} Mancini A....Di Battista J.A. (2007)
63. Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. (PubMed id 16243808)^{1, 9} Mrena J....Haglund C. (2005)
64. Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. (PubMed id 16083499)^{1, 9} Yoshida S....Adrian T.E. (2005)
65. The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. (PubMed id 14566822)^{1, 9} Park S.W....Sung M.W. (2003)
66. [Expression and function of cyclooxygenase-2 in endom etrial carcinoma] (PubMed id 20019776)^{1, 9} Chen J.Y. and Liao Q.P. (2009)
67. Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. (PubMed id 18498876)^{1, 9} Singh B....Lucci A. (2008)
68. The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. (PubMed id 18320325)^{1, 9} Zhang H....Wang S. (2008)
69. Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma. (PubMed id 18705402)^{1, 9} Do S.I....Park Y.K. (2008)
70. Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. (PubMed id 17341442)^{1, 9} Cao Z....Jiang B.H. (2007)
71. The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. (PubMed id 17429597)^{1, 9} Neuss H....Dubiel W. (2007)
72. EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. (PubMed id 18032824)^{1, 9} Konstantinopoulos P.A....Papavassiliou A.G. (2007)
73. Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. (PubMed id 16551850)^{1, 9} Castells A....Pique J.M. (2006)
74. Expression of cyclooxygenase isoforms in developing rat placenta, human term placenta, and BeWo human trophoblast model. (PubMed id 16323955)^{1, 9} Xu Y....Cook T.J. (2005)
75. Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. (PubMed id 16044148)^{1, 9} Yang W.L....Xu X.X. (2005)
76. Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. (PubMed id 15695237)^{1, 9} Nosho K....Imai K. (2005)
77. Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. (PubMed id 15754118)^{1, 9} Sivula A....Turpeenniemi-Hujanen T. (2005)
78. Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells. (PubMed id 15569819)^{1, 9} Michaelis U.R....Fleming I. (2005)
79. Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. (PubMed id 15010822)^{1, 9} Cheng A.S....Sung J.J. (2004)
80. Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas. (PubMed id 15569051)^{1, 9} Hemmerlein B....Heuser M. (2004)
81. Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer. (PubMed id 15228443)^{1, 9} Witton C.J....Bartlett J.M. (2004)
82. Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. (PubMed id 14760075)^{1, 9} Erkinheimo T.L....Ristimaki A. (2004)
83. Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. (PubMed id 15231484)^{1, 9} Souza R.F....Spechler S.J. (2004)
84. Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF. (PubMed id 12881220)^{1, 9} Wu G....Li J. (2003)
85. Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. (PubMed id 12532441)^{1, 9} Xue Y.W....Fu S.B. (2003)
86. Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. (PubMed id 12532440)^{1, 9} Guo X.L....Yuan Y. (2003)
87. Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu expression in ovarian cancer. (PubMed id 11972392)^{1, 9} Ferrandina G....Scambia G. (2002)
88. No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. (PubMed id 19437564)^{1, 9} Thompson C.L....Li L. (2009)
89. Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma. (PubMed id 19039588)^{1, 9} Johansson C.C....Kiessling R. (2009)
90. Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. (PubMed id 18181047)^{1, 9} Tang H....Fan D. (2008)
91. Coexpression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor: possible relations to pathological parameters and clinical behavior. (PubMed id 19260469)^{1, 9} Miao R....Li J. (2008)
92. [Correlation of Helicobacter pylori infection with the expression of COX-2 and EGFR and VEGF in human gastric carcinoma] (PubMed id 19173907)^{1, 9} Xiao W.M....Xue Y. (2008)
93. Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. (PubMed id 17332916)^{1, 9} Simeone A.M....Tari A.M. (2007)
94. [Blood vessel multiply and significance of expression of Cox-2, VEGF in pterygium] (PubMed id 17444036)^{1, 9} Yan M....Wang F. (2007)
95. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. (PubMed id 15222037)^{1, 9} Kasper H.U....Kern M.A. (2004)
96. COX-2 status in relation to tumor microvessel density and VEGF expression: analysis in ovarian carcinoma patients with low versus high survival rates. (PubMed id 14719060)^{1, 9} Raspollini M.R....Taddei G.L. (2004)
97. Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells. (PubMed id 15210717)^{1, 9} Kim S.Y....Min D.S. (2004)
98. Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. (PubMed id 15222024)^{1, 9} Li H.L....Ma F.C. (2004)
99. Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. (PubMed id 12883661)^{1, 9} Lim S.C....Do N.Y. (2003)
100. Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. (PubMed id 12883688)^{1, 9} Lim S.C. (2003)
101. Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. (PubMed id 12839952)^{1, 9} Liu W....Ellis L.M. (2003)
102. Expression of cyclooxygenase-2 in eutopic endometrium and ovarian endometriotic tissue in women with severe endometriosis. (PubMed id 20068324)^{1, 9} Cho S....Lee B.S. (2010)
103. Differential expression of cyclooxygenases in hypertr ophic scar and keloid tissues. (PubMed id 19769727)^{1, 9} Rossiello L....Rossiello R. (2009)
104. Cyclooxygenase-2 mediated regulation of E-cadherin oc curs in conventional but not early-onset gastric cancer cell lines. (PubMed id 19940363)^{1, 9} Sitarz R....Milne A.N. (2009)
105. Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors. (PubMed id 19845533)^{1, 9} TA1rkAPz H.K....Ozcan D. (2009)
106. [The expressions of PPAR-gamma, COX-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis] (PubMed id 19627000)^{1, 9} Ni J....Xue S.L. (2009)
107. Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associ ated with EBV infection. (PubMed id 19118057)^{1, 9} Park E.S....Kim K.M. (2009)
108. Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. (PubMed id 18663571)^{1, 9} Lucci A....Cristofanilli M. (2009)
109. Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis. (PubMed id 18053993)^{1, 9} Ceyhan S.T....Gunhan O. (2008)
110. Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cells. (PubMed id 18212353)^{1, 9} Casciani V....Challis J.R. (2008)
111. Prognostic value of COX-2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer. (PubMed id 19132985)^{1, 9} Zafirellis K....Zachaki A. (2008)
112. COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells. (PubMed id 18093816)^{1, 9} Futagami S....Sakamoto C. (2008)
113. COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. (PubMed id 17609663)^{1, 9} Cheng I....Witte J.S. (2007)
114. Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. (PubMed id 17511025)^{1, 9} Yoshikawa R....Tsujimura T. (2007)
115. Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction. (PubMed id 17868881)^{1, 9} Zidar N....Stajer D. (2007)
116. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. (PubMed id 17693978)^{1, 9} Maes M....Bosmans E. (2007)
117. YKL-40 in human lumbar herniated disc and its relationships with nitric oxide and cyclooxygenase-2. (PubMed id 17631744)^{1, 9} Pozzuoli A....Punzi L. (2007)
118. Analysis of renal immunoexpression of cyclooxygenase-1 and cyclooxygenase-2 in lupus and nonlupus membranous glomerulopathy. (PubMed id 18459455)^{1, 9} Danilewicz M. and Wagrowska-Danilewicz M. (2007)
119. Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma. (PubMed id 16169726)^{1, 9} Cho M.H....Min K.W. (2006)
120. Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis. (PubMed id 16456945)^{1, 9} Chou Y.C....Yuan C.C. (2006)
121. Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. (PubMed id 17192687)^{1, 9} Mohammad A.M....Eiman G. (2006)
122. COX-2 overexpression increases motility and invasion of breast cancer cells. (PubMed id 15809733)^{1, 9} Singh B....Lucci A. (2005)
123. Mechanism and clinical significance of cyclooxygenase-2 expression in gastric cancer. (PubMed id 15929174)^{1, 9} Wang B.C....Li D.G. (2005)
124. Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa. (PubMed id 15720413)^{1, 9} Bhandari P....Patel P. (2005)
125. Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. (PubMed id 14742690)^{7, 9} Mifflin R.C....Powell D.W. (2004)
126. The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis. (PubMed id 15301234)^{1, 9} Studynkova J.T....Gay S. (2004)
127. Expression of cyclooxygenase-2 and its correlation with clinicopathologic factors of ampulla of vater cancer. (PubMed id 12692419)^{1, 9} Kim H.J....Rhee J.C. (2003)
128. PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells. (PubMed id 12754192)^{1, 9} Chambers L.S....Burgess J.K. (2003)
129. Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis. (PubMed id 12970891)^{1, 9} Wu A.W....Xu G.W. (2003)
130. [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma] (PubMed id 12667327)^{1, 9} Pang D....Xue Y. (2002)
131. p38 MAPK plays a distinct role in sulforaphane-induce d up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells. (PubMed id 20204301)^{1, 9} Shan Y....Bao Y. (2010)
132. Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. (PubMed id 19280060)^{1, 9} Guo X....Yu X. (2009)
133. Cyclooxygenase-2 expression, Ki-67 labeling index, an d perifocal neovascularization in endometriotic lesions. (PubMed id 19917472)^{1, 9} Horn L.C....Leo C. (2009)
134. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. (PubMed id 19327107)^{1, 9} Xie X....Liu F. (2009)
135. COX-2 expression does not correlate with microvessel density in breast cancer. (PubMed id 19188749)^{1, 9} Thorat M.A....Badve S. (2009)
136. Cyclooxygenase-2 polymorphisms, aspirin treatment, an d risk for colorectal adenoma recurrence--data from a randomized clinical trial . (PubMed id 19755647)^{1, 9} Barry E.L....Baron J.A. (2009)
137. Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. (PubMed id 18985541)^{1, 9} Bartchewsky W....Ribeiro M.L. (2009)
138. [Expression of COX-2 and VEGF-C in papillary thyroid carcinoma and their relationship to cervical lymph metastases] (PubMed id 20120873)^{1, 9} Miao A....Cheng L. (2009)
139. Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. (PubMed id 19244345)^{1, 9} Rodriguez D.A....Quest A.F. (2009)
140. Cyclooxygenase-2 expression is associated with vascul ar endothelial growth factor-C and lymph node metastases in human prostate canc er. (PubMed id 19608016)^{1, 9} Di J.M....Ruan X.X. (2009)
141. Up-regulation of cyclooxygenase-2 expression and pros taglandin E2 production in human endometriotic cells by macrophage migration in hibitory factor: involvement of novel kinase signaling pathways. (PubMed id 19299454)^{1, 9} Carli C....Akoum A. (2009)
142. COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. (PubMed id 18753249)^{1, 9} Harrington L.S....Mitchell J.A. (2008)
143. Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. (PubMed id 18373164)^{1, 9} Futagami S....Sakamoto C. (2008)
144. Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells. (PubMed id 18565510)^{1, 9} Liou J.T....Lai J.H. (2008)
145. Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. (PubMed id 18190720)^{1, 9} Zhang X.H....Chen S.Y. (2008)
146. The COX-2 promoter polymorphism -765 G>C is associated with early-onset, conventional and stump gastric cancers. (PubMed id 18311113)^{1, 9} Sitarz R....Milne A.N. (2008)
147. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. (PubMed id 18565574)^{1, 9} Hammes L.S....Cunha-Filho J.S. (2008)
148. Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. (PubMed id 18334709)^{1, 9} Visscher D.W....Hartmann L.C. (2008)
149. Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells. (PubMed id 17982644)^{1, 9} Chan M.W....Leung W.K. (2007)
150. [Correlation of cyclooxygenase 2 with upstream mitoge n-activated protein kinase, nuclear factor kappa B signal transduction pathway in middle turbinate mucosa of chronic rhinosinusitis] (PubMed id 17702421)^{1, 9} Wang Z.L....Wei Y. (2007)
151. Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells. (PubMed id 17868457)^{1, 9} Shelby B.D....Sullivan D.E. (2007)
152. COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population. (PubMed id 18214026)^{1, 9} Hou L....Chow W.H. (2007)
153. Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. (PubMed id 17479405)^{1, 9} Gao J....Shen H.B. (2007)
154. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. (PubMed id 16570043)^{1, 9} Timoshenko A.V....Lala P.K. (2006)
155. A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells. (PubMed id 17156488)^{1, 9} Basu G.D....Mukherjee P. (2006)
156. PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. (PubMed id 16215757)^{1, 9} Vandoros G.P....Papavassiliou A.G. (2006)
157. Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. (PubMed id 16984258)^{1, 9} Zhang Q....Travers J.B. (2006)
158. The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production. (PubMed id 17178263)^{1, 9} Skarke C....Lotsch J. (2006)
159. Contribution of inducible nitric oxide synthase and cyclooxygenase-2 to apoptosis induction in smooth chorion trophoblast cells of human fetal membrane tissues. (PubMed id 16442500)^{1, 9} Yuan B....Toyoda H. (2006)
160. Increased cyclooxygenase-2 expression is associated with better clinical outcome in patients submitted to complete ablation for severe endometriosis. (PubMed id 15979990)^{1, 9} Fanfani F....Scambia G. (2005)
161. Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression. (PubMed id 16101131)^{1, 9} Uefuji K....Mochizuki H. (2005)
162. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. (PubMed id 15767259)^{1, 9} Kim H....LaMont J.T. (2005)
163. Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. (PubMed id 15704107)^{1, 9} Yuan A....Yang P.C. (2005)
164. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. (PubMed id 15655513)^{7, 9} Esser R....Marshall P.J. (2005)
165. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. (PubMed id 15896711)^{1, 9} Hwang J.T....Park O.J. (2005)
166. Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis. (PubMed id 16097070)^{1, 9} Yu J.R....Zheng S.S. (2005)
167. Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. (PubMed id 15330183)^{1, 9} Ranger G.S....Mokbel K. (2004)
168. COX-2 expression and tumor angiogenesis in colorectal cancer. (PubMed id 15285012)^{1, 9} Wu A.W....Xu G.W. (2004)
169. [Research on relationships of gastric cancer with ser um trace elements, Helicobacter pylori and COX-2 in gastric tissue] (PubMed id 15022477)^{1, 9} Li Y....Zhou Y. (2004)
170. Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells. (PubMed id 15331599)^{1, 9} Pawliczak R....Shelhamer J.H. (2004)
171. Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets. (PubMed id 15471850)^{1, 9} Heitmeier M.R....Maziasz T.J. (2004)
172. Reciprocal expression of peroxisome proliferator-activated receptor-gamma and cyclooxygenase-2 in human term parturition. (PubMed id 15042019)^{1, 9} Dunn-Albanese L.R....Kniss D.A. (2004)
173. [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] (PubMed id 14989896)^{1, 9} Yu H.P....Xu S.Q. (2004)
174. Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. (PubMed id 12957358)^{1, 9} Yu H.P....Li Y.Y. (2003)
175. Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. (PubMed id 12800231)^{1, 9} Xiong B....Cheng F.L. (2003)
176. Immunohistochemical analysis of cyclooxygenase-2 and vascular endothelial growth factor in pancreaticobiliary maljunction. (PubMed id 12579269)^{1, 9} Tsuchida A....Koyanagi Y. (2003)
177. Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. (PubMed id 14607721)^{1, 9} Wu G.S....Zou S.Q. (2002)
178. Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. (PubMed id 11957147)^{1, 9} Fujiwaki R....Miyazaki K. (2002)
179. Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging. (PubMed id 12162677)^{1, 9} Maitra A....Wilentz R.E. (2002)
180. Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. (PubMed id 11920515)^{1, 9} Niijima M....Saisho H. (2002)
181. PPARgamma agonists inhibit angiogenesis by suppressin g PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. (PubMed id 20032081)^{1, 9} Scoditti E....De Caterina R. (2010)
182. PTGS2 and IL6 genetic variation and risk of breast an d prostate cancer: results from the Breast and Prostate Cancer Cohort Consortiu m (BPC3). (PubMed id 19965896)^{1, 9} Dossus L....Cox D.G. (2010)
183. Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in ga stric mucosa with intestinal metaplasia or dysplasia. (PubMed id 20492336)^{1, 9} Liu D....Liu C. (2010)
184. Overexpression of cyclooxygenase-2 in urothelial carcinoma in conjunction with tumor-associated-macrophage infiltration, hypoxia-inducible factor-1alpha expression, and tumor angiogenesis. (PubMed id 19245590)^{1, 9} Chen W.T....Chai C.Y. (2009)
185. HGF/Met signalling promotes PGE(2) biogenesis via reg ulation of COX-2 and 15-PGDH expression in colorectal cancer cells. (PubMed id 19638428)^{1, 9} Moore A.E....Paraskeva C. (2009)
186. [Expression of cyclooxygenase-2 in bone marrow cells of leukemia patients and its association with angiogenesis] (PubMed id 19236744)^{1, 9} Liu X.W....Zhang D.X. (2009)
187. Expression of cyclooxygenase-2 and matrix metalloprot einase-2 in adenomyosis and endometrial polyps and its correlation with angioge nesis. (PubMed id 19188819)^{1, 9} Tokyol C....Arioz D.T. (2009)
188. Expression of p-Akt and COX-2 in gastric adenocarcino mas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric ad enocarcinoma and U251 glioma cell growth in vitro and in vivo. (PubMed id 19925030)^{1, 9} Zhang J....Kang C.S. (2009)
189. Involvement of mitogen-activated protein kinases and nuclear factor kappa B pathways in signaling COX-2 expression in chronic rhinos inusitis. (PubMed id 19319478)^{1, 9} Wang Z....Li Y. (2009)
190. Protein kinase D mediates synergistic expression of C OX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts. (PubMed id 19794144)^{1, 9} Yoo J....Rozengurt E. (2009)
191. Celecoxib potentiates the anticancer effect of cispla tin on vulvar cancer cells independently of cyclooxygenase. (PubMed id 19723114)^{1, 9} Kim S.H....Song Y.S. (2009)
192. Expression of prostaglandin metabolising enzymes COX- 2 and 15-PGDH and VDR in human granulosa cells. (PubMed id 19667156)^{1, 9} Thill M....Friedrich M. (2009)
193. [Effects of celecoxib on PGE2 synthesis and COX-2 and VEGF-C mRNA expression in Tca8113 cell lines.] (PubMed id 19304526)^{1, 9} Li W.Z....Ding Y.Q. (2009)
194. The role of COX-2 in rectal cancer treated with preoperative radiotherapy. (PubMed id 18392637)^{1, 9} Bouzourene H....Coucke P. (2008)
195. Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans. (PubMed id 19031967)^{1, 9} Ashktorab H....Ali I.U. (2008)
196. Cyclooxygenase-2 expression during immortalization and breast cancer progression. (PubMed id 18199541)^{1, 9} Zhao X....Band V. (2008)
197. Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2. (PubMed id 18029351)^{1, 9} Xu L....Wu T. (2008)
198. Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. (PubMed id 18237405)^{1, 9} Xu F....Shen H. (2008)
199. Inhibitory effect of interferon-alpha-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice. (PubMed id 19058305)^{1, 9} Cao B....Shi Z.L. (2008)
200. Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. (PubMed id 18758643)^{1, 9} Lazar D....Vernic C. (2008)
201. [Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis] (PubMed id 18950008)^{1, 9} Cui D....Fu Y. (2008)
202. Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. (PubMed id 17671679)^{1, 9} Noriyuki M....Ishiko O. (2007)
203. Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1. (PubMed id 17968936)^{1, 9} Jungel A....Distler J.H. (2007)
204. Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium. (PubMed id 17012371)^{1, 9} N'Guessan P.D....Hippenstiel S. (2007)
205. [Relationship between serum VEGF level and VEGF, COX-2 and MVD expression in breast cancer tissues] (PubMed id 18069633)^{1, 9} Li E.X....Dong D.F. (2007)
206. Expression of cyclooxygenase-2 and vascular endothelial growth factor in primary central nervous system lymphomas. (PubMed id 17671709)^{1, 9} Sugita Y....Nakashima A. (2007)
207. EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality. (PubMed id 17290397)^{1, 9} Gustafsson A....Lundholm K. (2007)
208. Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results. (PubMed id 16786043)^{1, 9} Mascaux C....Sculier J.P. (2006)
209. PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. (PubMed id 16820889)^{1, 9} Ikezoe T....Koeffler H.P. (2006)
210. Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. (PubMed id 16733863)^{1, 9} Legan M....Cor A. (2006)
211. Relationship between cyclooxygenase 8473T>C polymorphism and the risk of lung cancer: a case-control study. (PubMed id 16542464)^{1, 9} Park J.M....Park J.Y. (2006)
212. Molecular determinants in targeted therapy for esophageal adenocarcinoma. (PubMed id 16702519)^{1, 9} Vallbohmer D....DeMeester T.R. (2006)
213. Overexpression of cyclooxygenase-2 correlates with tumor angiogenesis in endometrial carcinoma. (PubMed id 16884383)^{1, 9} Li W....Jiang L.H. (2006)
214. COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. (PubMed id 15272284)^{1, 9} Kyzas P.A....Agnantis N.J. (2005)
215. Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. (PubMed id 16168133)^{1, 9} Surowiak P....Lage H. (2005)
216. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. (PubMed id 15863442)^{1, 9} Martey C.A....Phipps R.P. (2005)
217. Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. (PubMed id 15645120)^{1, 9} Kuroda J....Hashimoto-Tamaoki T. (2005)
218. The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta}. (PubMed id 15784717)^{1, 9} Sooranna S.R....Johnson M.R. (2005)
219. Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. (PubMed id 16278387)^{1, 9} Dalwadi H....Dubinett S. (2005)
220. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. (PubMed id 16203768)^{1, 9} Cianchi F....Masini E. (2005)
221. COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. (PubMed id 14735188)^{1, 9} Boland G.P....Bundred N.J. (2004)
222. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. (PubMed id 14769824)^{1, 9} Kuwano T....Ono M. (2004)
223. Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium. (PubMed id 15533352)^{1, 9} Matsuzaki S....Mage G. (2004)
224. Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. (PubMed id 15102673)^{1, 9} Cianchi F....Masini E. (2004)
225. Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts. (PubMed id 15246970)^{1, 9} Miura S....Sakamoto C. (2004)
226. Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. (PubMed id 15259059)^{1, 9} Jiang J.G....Wang D.W. (2004)
227. Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. (PubMed id 14747187)^{1, 9} Fagotti A....Scambia G. (2004)
228. Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts. (PubMed id 15106733)^{7, 9} Chae H.J....Kim H.R. (2004)
229. Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. (PubMed id 12727794)^{1, 9} Maihofner C....Gooderham N.J. (2003)
230. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. (PubMed id 12939602)^{1, 9} Leng J....Wu T. (2003)
231. Variation in cyclooxygenase expression levels within the colorectum. (PubMed id 12720297)^{1, 9} Wiese F.W....Kadlubar F.F. (2003)
232. Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas. (PubMed id 14550281)^{1, 9} Hur K....Yang H.K. (2003)
233. Cyclooxygenase-2 inhibitor NS398 enhances antitumor effect of irradiation on hormone refractory human prostate carcinoma cells. (PubMed id 14532848)^{1, 9} Wen B....Bourhis J. (2003)
234. Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. (PubMed id 12591723)^{1, 9} Heuze-Vourc'h N....Dubinett S.M. (2003)
235. ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells. (PubMed id 12761889)^{1, 9} Tsuzaki M....Banes A.J. (2003)
236. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. (PubMed id 12598658)^{1, 9} Inaba T....Nakada H. (2003)
237. Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1. (PubMed id 12763047)^{1, 9} Bakker A.D....Burger E.H. (2003)
238. Tumor necrosis factor alpha (TNF-alpha)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts. (PubMed id 12349897)^{1, 9} Nakao S....Sugiya H. (2002)
239. Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. (PubMed id 11939728)^{1, 9} Nose F....Okayasu I. (2002)
240. [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior] (PubMed id 12452062)^{1, 9} Ji S.Q....Shao Y.F. (2002)
241. Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2). (PubMed id 11006278)^{7, 9} Smith T....DeWitt D. (2000)
242. Structure-based design of COX-2 selectivity into flur biprofen. (PubMed id 10091674)^{7, 9} Bayly C.I....Percival M.D. (1999)
243. Heterogeneous expression of cyclooxygenase-2 and indu cible nitric oxide synthase within colorectal tumors: correlation with tumor an giogenesis. (PubMed id 19497798)^{1, 9} Cianchi F....Masini E. (2010)
244. Cigarette smoke and increased COX-2 and survivin leve ls in exhaled breath condensate of lung cancer patients: how hot is the link? (PubMed id 19423183)^{1, 9} Carpagnano G.E....Foschino Barbaro M.P. (2010)
245. The endogenous cannabinoid, anandamide, induces COX-2 -dependent cell death in apoptosis-resistant colon cancer cells. (PubMed id 20514410)^{1, 9} Patsos H.A....Williams A.C. (2010)
246. -765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies. (PubMed id 19669667)^{1, 9} Zhu W....Liu P. (2010)
247. Role of cyclooxygenase-2 and 5-lipoxygenase polymorph isms in Alzheimer's disease in a population from northern Italy: implication fo r pharmacogenomics. (PubMed id 20110601)^{1, 9} ListA- F....Candore G. (2010)
248. COX-2 expression in uterine carcinosarcoma. (PubMed id 19900134)^{1, 9} Menczer J....Levy T. (2010)
249. Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis. (PubMed id 19277703)^{1, 9} Huh J.W....Kim Y.J. (2009)
250. [Expressions of vascular endothelial growth factor and cyclooxygenase-2 in patients with multiple myeloma and its significance] (PubMed id 19236756)^{1, 9} Bao H.Y....Ruan C.G. (2009)
251. Expression of cyclooxygenase-1 and -2 in IL-1beta-ind uced synovitis of the temporomandibular joint. (PubMed id 19141058)^{1, 9} Satoh K....Kondoh T. (2009)
252. Glucocorticoid therapy increases COX-2 gene expression in nasal polyps in vivo. (PubMed id 19251796)^{1, 9} Pujols L....Picado C. (2009)
253. Cross-talk between inducible nitric oxide synthase an d cyclooxygenase in Helicobacter-pylori-induced gastritis. (PubMed id 19797925)^{1, 9} Franco L. and Talamini G. (2009)
254. Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. (PubMed id 19422084)^{1, 9} Zhao D....Lin D. (2009)
255. Tpl-2/Cot and COX-2 in breast cancer. (PubMed id 18795070)^{1, 9} Krcova Z....Kolar Z. (2008)
256. Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells. (PubMed id 17889855)^{1, 9} Tsai E.M....Lee J.N. (2008)
257. Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. (PubMed id 19088039)^{1, 9} Ogino S....Fuchs C.S. (2008)
258. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. (PubMed id 18469157)^{1, 9} Dillon M.F....Young L.S. (2008)
259. Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. (PubMed id 18356024)^{1, 9} Pandey M....Pillai R.M. (2008)
260. COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. (PubMed id 18974063)^{1, 9} Fernandez P....Heyns C.F. (2008)
261. Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer. (PubMed id 18000398)^{1, 9} Matsubayashi H....Goggins M. (2007)
262. Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. (PubMed id 17594159)^{1, 9} Lim S.C....Min Y.D. (2007)
263. Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas. (PubMed id 17592548)^{1, 9} Wu R....Steinberg B.M. (2007)
264. Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. (PubMed id 17711445)^{1, 9} Yuri M....Kuniyasu H. (2007)
265. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. (PubMed id 17881124)^{1, 9} Boetkjaer A....Lukiw W.J. (2007)
266. Prostacyclin production is not controlled by prostacyclin synthase but by cyclooxygenase-2 in a human follicular dendritic cell line, HK. (PubMed id 17337058)^{1, 9} Lee I.Y....Choe J. (2007)
267. [COX-2 and mPGES-1 expression in carotid atherosclerotic plaques] (PubMed id 17680542)^{1, 9} Liu H.F....Zhang F.Q. (2007)
268. [Expression of COX-2 and MMP-9 in cervical carcinoma and their clinical significance] (PubMed id 18069634)^{1, 9} Luo C.F....Lu Y.L. (2007)
269. Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. (PubMed id 17640058)^{1, 9} Hubner R.A....Houlston R.S. (2007)
270. [The expression and significance of HIF-1alpha and COX-2 in laryngeal squamous cell carcinoma] (PubMed id 18062281)^{1, 9} Yin S. (2007)
271. Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. (PubMed id 16393343)^{1, 9} Durrenberger P.F....Anand P. (2006)
272. RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor. (PubMed id 16731743)^{1, 9} Narayanan B.A....Nargi D. (2006)
273. COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States). (PubMed id 16489533)^{1, 9} Sansbury L.B....Sandler R.S. (2006)
274. Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray. (PubMed id 16481301)^{1, 9} Xu L....Gao H.J. (2006)
275. IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer. (PubMed id 16574063)^{1, 9} Cui X....Dubinett S.M. (2006)
276. Expression of cyclooxygenase-2 in epithelial ovarian tumors and its relation to vascular endothelial growth factor and p53 expression. (PubMed id 16515599)^{1, 9} Lee J.S....Min K.W. (2006)
277. Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. (PubMed id 16343055)^{1, 9} Grau R....Iniguez M.A. (2006)
278. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. (PubMed id 16505480)^{1, 9} Yiu G.K. and Toker A. (2006)
279. Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. (PubMed id 15864753)^{1, 9} Huang S.P....Lin J.T. (2005)
280. Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells. (PubMed id 15878911)^{1, 9} Abdalla S.I....Fitzgerald R.C. (2005)
281. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. (PubMed id 16087791)^{1, 9} McAdam B.F....Oates J.A. (2005)
282. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. (PubMed id 15632146)^{1, 9} Duque J....Iniguez M.A. (2005)
283. The use and safety profile of non-steroidal antiinfla mmatory drugs among Turkish patients with osteoarthritis. (PubMed id 16245223)^{7, 9} Yilmaz H....Ozdemir O. (2005)
284. Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. (PubMed id 15713675)^{1, 9} Tong X....Giardina C. (2005)
285. Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. (PubMed id 15856454)^{1, 9} Sivula A....Ristimaki A. (2005)
286. Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. (PubMed id 16005433)^{1, 9} Lee J....Park K. (2005)
287. Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. (PubMed id 15550400)^{1, 9} Liu X.H....Levine A.C. (2005)
288. Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. (PubMed id 15598423)^{7, 9} Payvandi F....Stirling D.I. (2004)
289. Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. (PubMed id 15334675)^{1, 9} Sun W.H....Su H. (2004)
290. Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. (PubMed id 15355919)^{1, 9} Adegboyega P.A....Powell D.W. (2004)
291. Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. (PubMed id 15102535)^{7, 9} Padi S.S....Kulkarni S.K. (2004)
292. Cyclooxygenase-2 parallels invasive depth and increased MVD in transitional cell carcinoma. (PubMed id 15450303)^{1, 9} Li G....Zhang Y. (2004)
293. [Proliferation inhibition effect of indomethacin on C ML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhi bition of COX-2 expression.] (PubMed id 15730717)^{7, 9} Zhang G.S....Xia M. (2004)
294. Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. (PubMed id 15151617)^{1, 9} Yu H.P....Xu S.Q. (2004)
295. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. (PubMed id 15063780)^{1, 9} Tong X....Giardina C. (2004)
296. [COX-2-expression in extragenital endometriosis lesions as a novel therapeutical approach?] (PubMed id 14505259)^{1, 9} Bartley J....Ebert A.D. (2003)
297. PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. (PubMed id 12821125)^{1, 9} Eibl G....Hines O.J. (2003)
298. Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. (PubMed id 12679908)^{1, 9} Li H.X....He S.X. (2003)
299. Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer. (PubMed id 12533667)^{1, 9} Chu J....Rizzo M.T. (2003)
300. Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. (PubMed id 12954496)^{1, 9} Gee J.R....Grossman H.B. (2003)
301. Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. (PubMed id 12907138)^{1, 9} Jiang W.G....Mansel R.E. (2003)
302. Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. (PubMed id 12592372)^{1, 9} Spizzo G....Obrist P. (2003)
303. [Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer] (PubMed id 12600292)^{1, 9} Chen Z.K. and Ouyang Z.T. (2003)
304. Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. (PubMed id 11809750)^{1, 9} Pontsler A.V....McIntyre T.M. (2002)
305. Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. (PubMed id 11844819)^{1, 9} Ferrandina G....Ranelletti F.O. (2002)
306. Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. (PubMed id 12393863)^{1, 9} Zeng Q....Wang C.Y. (2002)
307. Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. (PubMed id 11948128)^{1, 9} Asano T....Miwa M. (2002)
308. Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. (PubMed id 12324457)^{1, 9} Lim J.W....Kim K.H. (2002)
309. Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. (PubMed id 10657949)^{7, 9} Yip-Schneider M.T....Sweeney C.J. (2000)
310. Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects. (PubMed id 10381787)^{7, 9} Panara M.R....Patrignani P. (1999)
311. Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebo controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group. (PubMed id 10555907)^{7, 9} Ehrich E.W....Gertz B.J. (1999)
312. Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial. (PubMed id 10566562)^{7, 9} Malmstrom K....Desjardins P.J. (1999)
313. Protective effect of sulforaphane on human vascular e ndothelial cells against lipopolysaccharide-induced inflammatory damage. (PubMed id 20405237)^{1, 9} Shan Y....Wang S. (2010)
314. Progress in COX-2 inhibitors: a journey so far. (PubMed id 20166930)^{7, 9} Chakraborti A.K....Jadhavar P.S. (2010)
315. Comparative analysis of clinicopathological correlati ons of cyclooxygenase-2 expression in resectable pancreatic cancer. (PubMed id 20397266)^{1, 9} Hermanova M....Dite P. (2010)
316. Localization of cyclo-oxygenase-2 in human recurrent colorectal cancer. (PubMed id 20144265)^{1, 9} Loukanov T.s....MA1ller-Decker K. (2010)
317. Cyclooxygenase-2 and 5-lipoxygenase pathways in diosg enin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. (PubMed id 20372792)^{1, 9} Lepage C....Beneytout J.L. (2010)
318. Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer. (PubMed id 20332326)^{1, 9} Bi N....Wang L. (2010)
319. Toll-like receptor 9 agonists up-regulates the expres sion of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells. (PubMed id 19618291)^{1, 9} Di J.M....Gao X. (2010)
320. Antitumor effects of inhibitors of nitric oxide synth ase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. (PubMed id 20514441)^{1, 9} Ohtsu N....Urade M. (2010)
321. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. (PubMed id 19723094)^{1, 9} Lee Y.K....Park O.J. (2009)
322. No association between the PPARG gene and schizophren ia in a British population. (PubMed id 19560328)^{1, 9} Mathur A....Wei J. (2009)
323. The relationship between cyclooxygenase-2, CD44v6, an d nm23H1 in esophageal squamous cell carcinoma. (PubMed id 19816074)^{1, 9} Liu W.K....Zhang Z.X. (2009)
324. Nicotinamide phosphoribosyltransferase and prostaglan din H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells aft er stimulation with interleukin-1. (PubMed id 19513556)^{1, 9} Bauer L....Radons J. (2009)
325. [Effect of clarithromycin on the expressions of cyclo oxygenase-2 and nuclear factor-kappa B in nasal polyps in vitro] (PubMed id 20030038)^{1, 9} Zhang M....Zhang Q. (2009)
326. Polymorphism in COX-2 modifies the inverse associatio n between Helicobacter pylori seropositivity and esophageal squamous cell carci noma risk in Taiwan: a case control study. (PubMed id 19463183)^{1, 9} Hu H.M....Wu D.C. (2009)
327. The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-depen dent and -independent pathways. (PubMed id 19467701)^{1, 9} Chang M.C....Jeng J.H. (2009)
328. Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. (PubMed id 19505922)^{1, 9} Takai T....Hishida A. (2009)
329. The activated Notch1 signal pathway is associated wit h gastric cancer progression through cyclooxygenase-2. (PubMed id 19491270)^{1, 9} Yeh T.S....Chi C.W. (2009)
330. Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. (PubMed id 19218340)^{1, 9} Itatsu K....Nakanuma Y. (2009)
331. COX-2 polymorphisms in patients with familial adenoma tous polyposis. (PubMed id 19544971)^{1, 9} Peters W.H....Nagengast F.M. (2009)
332. Cyclooxygenase-2 up-regulates ataxia telangiectasia a nd Rad3 related through extracellular signal-regulated kinase activation. (PubMed id 19584262)^{1, 9} Kim Y.M....Pyo H. (2009)
333. Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. (PubMed id 19241124)^{1, 9} Kurihara Y....Shintani S. (2009)
334. Correlation of cyclooxygenase 2 expression and inflam matory cells infiltration in colorectal cancer. (PubMed id 19579928)^{1, 9} Naghshvar F....Ghahremani M. (2009)
335. Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB. (PubMed id 19940361)^{1, 9} Zatelli M.C....degli Uberti E. (2009)
336. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PubMed id 19276290)^{1, 9} Abraham J.E....Pharoah P.D. (2009)
337. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. (PubMed id 19058955)^{1, 9} Madden K....Mohammed S.I. (2009)
338. Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. (PubMed id 19287974)^{1, 9} Kobayashi H....Danenberg P.V. (2009)
339. MBP-1 suppresses growth and metastasis of gastric can cer cells through COX-2. (PubMed id 19846662)^{1, 9} Hsu K.W....Yeh T.S. (2009)
340. Matrix Metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps. (PubMed id 17624726)^{1, 9} Karahan N....Kapucuoglu N. (2009)
341. COX-2 polymorphisms -765G-->C and -1195A-->G an d colorectal cancer risk. (PubMed id 19777615)^{1, 9} Hoff J.H....Peters W.H. (2009)
342. [Expression of cyclooxygenase-2 and relationship with mismatch repair gene and microsatellite instability in hereditary non-polyposi s colorectal cancer] (PubMed id 19671325)^{1, 9} Zhang Y.H....Li S.R. (2009)
343. [Expression of P53, COX2 and CD44V6 in early-stage sq uamous carcinoma of cervix with lymph vascular space invasion positive and nega tive and its relationship with prognosis] (PubMed id 20193563)^{1, 9} Zhang R....Wang Y. (2009)
344. Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. (PubMed id 19318593)^{1, 9} Alvarez Y....FernA!ndez N. (2009)
345. Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma. (PubMed id 19329856)^{1, 9} Gao Y.W....Chen W. (2009)
346. [The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma] (PubMed id 19452725)^{1, 9} Bai W. and Tang J. (2009)
347. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. (PubMed id 19318492)^{1, 9} Fradet V....Witte J.S. (2009)
348. Effects of cotreatment of 12-O-tetradecanoylphorbol-1 3-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyc looxygenase-2 signals. (PubMed id 19723105)^{1, 9} Lee Y.K....Park O.J. (2009)
349. Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. (PubMed id 19217709)^{1, 9} Duarte M.L....Ferreira C.G. (2009)
350. The effect of cyclooxygenase-2 expression on tumor vo lume response in patients treated with radiotherapy for uterine cervical cancer . (PubMed id 19949677)^{1, 9} Kang M.K....Kim B.G. (2009)
351. Inhibition of 12-LOX and COX-2 reduces the proliferat ion of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-A kt signalling pathways. (PubMed id 19558494)^{1, 9} Agarwal S....Reddanna P. (2009)
352. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. (PubMed id 19056653)^{1, 9} Degner S.C....Romagnolo D.F. (2009)
353. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. (PubMed id 18326857)^{1, 9} Misra S....Ghatak S. (2008)
354. Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: the Self Defense Forces Health Study. (PubMed id 18167131)^{1, 9} Ueda N....Kono S. (2008)
355. Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. (PubMed id 18349295)^{1, 9} Ferguson H.R....Hardie L.J. (2008)
356. Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication? (PubMed id 18718465)^{1, 9} Clarkin C.E....Wheeler-Jones C.P. (2008)
357. [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] (PubMed id 18250037)^{1, 9} Li W.Z....Zhang J.H. (2008)
358. Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy. (PubMed id 18825488)^{1, 9} Achyut B.R....Mittal B. (2008)
359. Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese. (PubMed id 17234302)^{1, 9} Ma S.L....Lam L.C. (2008)
360. [The expression of COX-2 mRNA and protein in human laryngeal squamous cell carcinoma] (PubMed id 18800677)^{1, 9} Chen W....Liu B. (2008)
361. [Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma] (PubMed id 18841789)^{1, 9} Cui D....Zhang X. (2008)
362. 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. (PubMed id 18555503)^{1, 9} Le Mee S....Morfin R. (2008)
363. Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. (PubMed id 18395088)^{1, 9} Subramaniam D....Anant S. (2008)
364. Cyclooxygenase-2 expression in human thyroid disease. (PubMed id 18362501)^{1, 9} Lee K.J....Soh E.Y. (2008)
365. Cyclooxygenase-2 polymorphisms and risk of rheumatoid arthritis in Koreans. (PubMed id 18381795)^{1, 9} Yun H.R....Bae S.C. (2008)
366. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. (PubMed id 18048499)^{1, 9} Bukulmez O....Mendelson C.R. (2008)
367. The prognostic significance of COX-2 and survivin expression in ovarian cancer. (PubMed id 18171606)^{1, 9} Athanassiadou P....Patsouris E. (2008)
368. Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. (PubMed id 18775915)^{1, 9} Park M.J....Cheong J. (2008)
369. Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. (PubMed id 17999989)^{1, 9} Danforth K.N....Hsing A.W. (2008)
370. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. (PubMed id 18202756)^{1, 9} Niesporek S....Denkert C. (2008)
371. COX-2/EGFR expression and survival among women with adenocarcinoma of the lung. (PubMed id 18453539)^{1, 9} Van Dyke A.L....Schwartz A.G. (2008)
372. In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA. (PubMed id 18695918)^{1, 9} Takaoka K....Urade M. (2008)
373. Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. (PubMed id 18462890)^{1, 9} Yamac D....Koybasioglu F. (2008)
374. The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. (PubMed id 18381949)^{1, 9} Fidler M.J....Bonomi P. (2008)
375. [Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer] (PubMed id 19062735)^{1, 9} Xu D.K....Lin D.X. (2008)
376. Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. (PubMed id 17553653)^{1, 9} Takatori H....Aikou T. (2008)
377. Relevance of COX-2 gene expression in dementia with lewy bodies associated with Alzheimer pathology. (PubMed id 18307244)^{1, 9} Saldana M....Marin C. (2008)
378. Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. (PubMed id 17962194)^{1, 9} Wang H....MacNaughton W.K. (2008)
379. The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. (PubMed id 18953425)^{1, 9} Stasinopoulos I....Bhujwalla Z.M. (2008)
380. Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. (PubMed id 18319253)^{1, 9} Pan M.R....Hung W.C. (2008)
381. Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index. (PubMed id 18350611)^{1, 9} Xing L.L....Zhang X. (2008)
382. Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. (PubMed id 18262731)^{1, 9} Haffty B.G....Reiss M. (2008)
383. MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer. (PubMed id 17851225)^{1, 9} Pan J.H....Yu Q.Z. (2008)
384. Normal or stress-induced fibroblast senescence involves COX-2 activity. (PubMed id 17560572)^{1, 9} Zdanov S....Abbadie C. (2007)
385. Increased expression of CCAAT/enhancer-binding protein beta in proliferative inflammatory atrophy of the prostate: relation with the expression of COX-2, the androgen receptor, and presence of focal chronic inflammation. (PubMed id 17570496)^{1, 9} Wang W....Damber J.E. (2007)
386. Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. (PubMed id 17436372)^{7, 9} Kim S.J....Um J.Y. (2007)
387. [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] (PubMed id 18159174)^{1, 9} Joo H.H....Choi Y.K. (2007)
388. [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] (PubMed id 17672932)^{1, 9} Liu J.R....Liu J.L. (2007)
389. Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population. (PubMed id 17404026)^{1, 9} Lee T.S....Song Y.S. (2007)
390. Expression of glycodelin and cyclooxygenase-2 in human endometrial tissue following three-dimensional culture. (PubMed id 17156191)^{1, 9} Esfandiari N....Casper R.F. (2007)
391. Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism. (PubMed id 17066444)^{1, 9} Hedelin M....Balter K.A. (2007)
392. EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. (PubMed id 17616668)^{1, 9} Xu K. and Shu H.K. (2007)
393. Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients. (PubMed id 17295901)^{1, 9} Chishima F....Nemoto N. (2007)
394. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. (PubMed id 17328065)^{1, 9} Brechter A.B. and Lerner U.H. (2007)
395. Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. (PubMed id 17581404)^{1, 9} Baltazar F....Schmitt F.C. (2007)
396. Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus. (PubMed id 16917094)^{1, 9} Szerafin T....Bagi Z. (2006)
397. Genetic variation in the COX-2 gene and the association with prostate cancer risk. (PubMed id 16506214)^{1, 9} Shahedi K....Xu J. (2006)
398. Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. (PubMed id 16820089)^{1, 9} Crowell P.L....Cummings W.O. (2006)
399. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. (PubMed id 16846546)^{7, 9} Waterbury L.D....Jolas T. (2006)
400. Complete and long-lasting regression of disseminated multiple skin melanoma metastases under treatment with cyclooxygenase-2 inhibitor. (PubMed id 16718274)^{1, 9} Lejeune F.J....Ruegg C. (2006)
401. Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs. (PubMed id 16678543)^{1, 9} Lee Y.S....Dionne R.A. (2006)
402. Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. (PubMed id 16908593)^{1, 9} Tsai W.C....Wu L.W. (2006)
403. Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. (PubMed id 16474989)^{1, 9} Soumaoro L.T....Sugihara K. (2006)
404. Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. (PubMed id 16521222)^{1, 9} Li Y....Martin R.C. (2006)
405. Significance of COX-2 expression in human esophageal squamous cell carcinoma. (PubMed id 16352617)^{1, 9} Zhi H....Liu Z. (2006)
406. Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. (PubMed id 16550596)^{1, 9} Shimizu D....Danenberg P.V. (2006)
407. Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. (PubMed id 16111807)^{1, 9} Kang S....Song Y.S. (2006)
408. Cyclooxygenase-2 genotype and rheumatoid arthritis. (PubMed id 16821264)^{1, 9} Lee K.H....Bae S.C. (2006)
409. QSAR analysis of meclofenamic acid analogues as selec tive COX-2 inhibitors. (PubMed id 16290292)^{7, 9} Narsinghani T. and Chaturvedi S.C. (2006)
410. Partnering between monomers of cyclooxygenase-2 homodimers. (PubMed id 16606823)^{1, 9} Yuan C....Smith W.L. (2006)
411. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. (PubMed id 16723309)^{1, 9} Maia H....Coutinho E.M. (2006)
412. Heregulin-alpha and heregulin-beta expression is linked to a COX-2-PGE2 pathway in human gastric fibroblasts. (PubMed id 16357062)^{1, 9} Nagata K....Sakamoto C. (2006)
413. Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids. (PubMed id 15869467)^{1, 9} Ciccoli R....Nigam S. (2005)
414. Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins. (PubMed id 15591227)^{1, 9} Rabausch K....Weber A.A. (2005)
415. E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. (PubMed id 15800927)^{1, 9} Boedefeld W.M....Heslin M.J. (2005)
416. Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. (PubMed id 15494548)^{7, 9} Gierse J.K....Seibert K. (2005)
417. Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. (PubMed id 16237757)^{1, 9} Shida D....Nagawa H. (2005)
418. Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis. (PubMed id 15982930)^{7, 9} Du G.J....Wang M.W. (2005)
419. Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. (PubMed id 15754411)^{1, 9} Chen X.L....Wang Y.L. (2005)
420. Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1. (PubMed id 15963597)^{1, 9} Cheng J....Hada T. (2005)
421. [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] (PubMed id 16494037)^{1, 9} Sun X....Zheng C. (2005)
422. Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis. (PubMed id 16419156)^{1, 9} Liu N.B....Leng J. (2005)
423. COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. (PubMed id 15645119)^{1, 9} Honjo S....Ito H. (2005)
424. Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells. (PubMed id 15950779)^{1, 9} Moolwaney A.S. and Igwe O.J. (2005)
425. Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. (PubMed id 15756444)^{1, 9} Takatori H....Aikou T. (2005)
426. The role of CCAAT/enhancer-binding protein beta in the transcriptional regulation of COX-2 in human amnion. (PubMed id 16399783)^{1, 9} Lee Y.S....Bennett P.R. (2005)
427. Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium. (PubMed id 15599594)^{1, 9} Horn L.C....Leo C. (2005)
428. Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia. (PubMed id 15276698)^{1, 9} Yokota O....Kuroda S. (2004)
429. Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer. (PubMed id 15374967)^{1, 9} Pold M....Dubinett S.M. (2004)
430. Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: a potential predictor of poor survival. (PubMed id 14977838)^{1, 9} Kim G.E....Suh C.O. (2004)
431. Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression. (PubMed id 14555963)^{1, 9} Bizik J....Vaheri A. (2004)
432. Pharmacology and gastrointestinal safety of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor: An integrated study. (PubMed id 15017615)^{7, 9} Atherton C....Hawkey C.J. (2004)
433. Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis. (PubMed id 14726416)^{1, 9} Tanaka N....Morita I. (2004)
434. No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor. (PubMed id 15177307)^{7, 9} Kalbag J....Rordorf C. (2004)
435. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PubMed id 15574495)^{1, 9} Yan M.... Markowitz S.D. (2004)
436. Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. (PubMed id 14871981)^{1, 9} Golijanin D....Dannenberg A.J. (2004)
437. Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44. (PubMed id 16035618)^{1, 9} Kinugasa Y....Nagumo M. (2004)
438. Prognostic role of the ratio between cyclooxygenase-2 in tumor and stroma compartments in cervical cancer. (PubMed id 15131052)^{1, 9} Ferrandina G....Scambia G. (2004)
439. Cyclooxygenase-2 expression in the hereditary mixed polyposis syndrome. (PubMed id 15628724)^{1, 9} Brazowski E....Rozen P. (2004)
440. Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products. (PubMed id 12837757)^{1, 9} Shanmugam N....Natarajan R. (2003)
441. Interaction of rofecoxib and celecoxib with warfarin. (PubMed id 12901032)^{7, 9} Schaefer M.G....Egan M. (2003)
442. Aspirin and other cyclooxygenase inhibitors: new ther apeutic insights. (PubMed id 15199473)^{7, 9} Wu K.K. (2003)
443. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. (PubMed id 12750248)^{1, 9} Shim V....Esserman L.J. (2003)
444. Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. (PubMed id 12555215)^{1, 9} Zaitsu M....Ishii E. (2003)
445. Characterization of celecoxib and valdecoxib binding to cyclooxygenase. (PubMed id 12644588)^{7, 9} Hood W.F....Monahan J.B. (2003)
446. Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. (PubMed id 14681319)^{1, 9} Shim J.Y....Lee K.S. (2003)
447. Induction of cyclooxygenase-2 mRNA and protein expression in human pulp cells stimulated with black-pigmented bacteroides. (PubMed id 12701770)^{1, 9} Chang Y.C....Hsieh Y.S. (2003)
448. Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. (PubMed id 12821538)^{1, 9} Sennlaub F....Chemtob S. (2003)
449. Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. (PubMed id 12743126)^{1, 9} Abulencia J.P....Konstantopoulos K. (2003)
450. Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. (PubMed id 12875991)^{1, 9} Gallo O....Capaccioli S. (2003)
451. Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell lines. (PubMed id 12800245)^{1, 9} Wu G.S....Wang J.H. (2003)
452. Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. (PubMed id 12771929)^{1, 9} Charalambous M.P....Gooderham N.J. (2003)
453. p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. (PubMed id 12882963)^{1, 9} Dean J.L....Saklatvala J. (2003)
454. [Relation between COX-2 protein expression and biolog ic behavior of ovarian carcinoma] (PubMed id 12839690)^{1, 9} Tang L.X....Ma J.W. (2003)
455. Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. (PubMed id 12684668)^{1, 9} Yu J....Sung J.J. (2003)
456. Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2. (PubMed id 14623265)^{1, 9} Corazzi T....Gresele P. (2003)
457. Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. (PubMed id 14596920)^{1, 9} Ogawa H....Binion D.G. (2003)
458. Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer. (PubMed id 12855643)^{1, 9} Davies G....Dowsett M. (2003)
459. Clinical pharmacology of selective COX-2 inhibitors. (PubMed id 14552704)^{7, 9} Capone M.L....Patrignani P. (2003)
460. Cyclooxygenase-2 expression in the gallbladder of patients with anomalous arrangement of the pancreaticobiliary duct. (PubMed id 12677571)^{1, 9} Fumino S....Iwai N. (2003)
461. Mechanisms of action of paracetamol and related analgesics. (PubMed id 15035793)^{7, 9} Graham G.G. and Scott K.F. (2003)
462. Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. (PubMed id 12698187)^{1, 9} Maaser K....Scherubl H. (2003)
463. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. (PubMed id 14507922)^{1, 9} Qin W....Pasinetti G.M. (2003)
464. Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. (PubMed id 12767532)^{1, 9} Shoji T....Nakamura S. (2003)
465. Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. (PubMed id 14675489)^{1, 9} Carlson M.L....Prescott S.M. (2003)
466. Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib. (PubMed id 11911965)^{1, 9} Patti R....Reddy C.D. (2002)
467. Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human. (PubMed id 12167567)^{7, 9} Yuan J.J....Findlay J.W. (2002)
468. Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. (PubMed id 11809691)^{1, 9} Sales K.J....Soeters R.P. (2002)
469. Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer. (PubMed id 12197220)^{1, 9} Badawi A.F....Michael M.S. (2002)
470. Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma. (PubMed id 11920472)^{1, 9} Hasturk S....Lee J.S. (2002)
471. Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. (PubMed id 11901151)^{1, 9} Subbaramaiah K....Dannenberg A.J. (2002)
472. Increased cyclooxygenase-2 expression in human squamous cell carcinomas of the head and neck and inhibition of proliferation by nonsteroidal anti-inflammatory drugs. (PubMed id 12174888)^{1, 9} Lee D.W....Kim K.H. (2002)
473. Significance of cyclooxygenase-2 expression in human primary hepatocellular carcinoma. (PubMed id 12378621)^{1, 9} Qiu D.K....Chen X.Y. (2002)
474. An immunohistochemical study of cyclooxygenase (COX)-2 expression in endocrine tumors of the pancreas. (PubMed id 12636104)^{1, 9} Okami J....Monden M. (2002)
475. ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. (PubMed id 12143054)^{1, 9} Endo K....Sirica A.E. (2002)
476. Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction. (PubMed id 11880271)^{1, 9} Mifflin R.C....Powell D.W. (2002)
477. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. (PubMed id 12218179)^{1, 9} Rossi D.J....Makela T.P. (2002)
478. Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. (PubMed id 12393872)^{1, 9} Dohadwala M....Dubinett S.M. (2002)
479. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. (PubMed id 12072439)^{1, 9} Monick M.M....Hunninghake G.W. (2002)
480. Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens. (PubMed id 11894121)^{1, 9} Swamy M.V....Rao C.V. (2002)
481. In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflamm atory genes in the brain. (PubMed id 12446609)^{7, 9} Blais V....Rivest S. (2002)
482. Recognition of cyclooxygenase-2 (COX-2) active site b y NSAIDs: a computer modelling study. (PubMed id 11563332)^{7, 9} Kothekar V....Mishra J. (2001)
483. Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. (PubMed id 11687965)^{1, 9} King J.G. and Khalili K. (2001)
484. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. (PubMed id 11275997)^{7, 9} Chen W.S....Yang W.K. (2001)
485. Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells. (PubMed id 11913955)^{1, 9} Goldmann W.H....Sharma C.P. (2001)
486. Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group. (PubMed id 10693877)^{7, 9} Hawkey C....Mortensen E. (2000)
487. Cyclooxygenase-2 in human perinatal lung. (PubMed id 10813584)^{1, 9} Lassus P....Andersson S. (2000)
488. Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. (PubMed id 10075740)^{1, 9} Meade E.A....Prescott S.M. (1999)
489. Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state. (PubMed id 10340919)^{7, 9} Tegeder I....Geisslinger G. (1999)
490. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. (PubMed id 10381057)^{7, 9} Blanco F.J....Galdo F. (1999)
491. Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells. (PubMed id 9661070)^{1, 9} Min Y.K....Pilbeam C.C. (1998)
492. Expression and selective inhibition of the constituti ve and inducible forms of human cyclo-oxygenase. (PubMed id 7832763)^{7, 9} Gierse J.K....Seibert K. (1995)
493. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. (PubMed id 20028875)^{1, 9} Fordyce C....Tlsty T. (2010)
494. Functional promoter polymorphism of cyclooxygenase-2 modulates the inflammatory response in stable coronary heart disease. (PubMed id 20332714)^{1, 9} Sanak M....Szczeklik A. (2010)
495. Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lip oteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. (PubMed id 20167866)^{1, 9} Lee I.T....Yang C.M. (2010)
496. TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benig n, not in malignant keratinocytes. (PubMed id 20399617)^{1, 9} RAosAonen K. and Vaheri A. (2010)
497. Lipopolysaccharide promoted proliferation and invasio n of endometriotic stromal cells via induction of cyclooxygenase-2 expression. (PubMed id 19647233)^{1, 9} Takenaka Y....Harada T. (2010)
498. Human glomerular endothelium: interplay among glucose , free fatty acids, angiotensin II, and oxidative stress. (PubMed id 19864304)^{1, 9} Jaimes E.A....Raij L. (2010)
499. COX-2 is overexpressed in primary prostate cancer wit h metastatic potential and may predict survival. A comparison study between COX -2, TGF-beta, IL-10 and Ki67. (PubMed id 20409773)^{1, 9} Richardsen E....Busund L.T. (2010)
500. The contribution of cyclooxygenase-1 and -2 to persis tent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: imp lications for antiplatelet therapy. (PubMed id 19887674)^{1, 9} Dragani A....Rocca B. (2010)
501. Functional rs20417 SNP (-765G>C) of cyclooxygenase -2 gene does not predict the risk of recurrence of ischemic events in coronary patients: results of a 7-year prospective study. (PubMed id 20299798)^{1, 9} Montali A....Arca M. (2010)
502. Associations between COX-2 polymorphisms, blood chole sterol and risk of acute coronary syndrome. (PubMed id 19748095)^{1, 9} Vogel U....Overvad K. (2010)
503. Decreased TGFbeta signaling and increased COX2 expres sion in high risk women with increased mammographic breast density. (PubMed id 19241157)^{1, 9} Yang W.T....Chang J.C. (2010)
504. Neutrophil expression of cyclooxygenase 2 in preeclam psia. (PubMed id 20220108)^{1, 9} Bachawaty T....Walsh S.W. (2010)
505. Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population. (PubMed id 18819034)^{1, 9} Ostergaard M....Andersen V. (2009)
506. Paradoxical stimulation of cyclooxygenase-2 expressio n by glucocorticoids via a cyclic AMP response element in human amnion fibrobla sts. (PubMed id 19797430)^{1, 9} Zhu X.O....Sun K. (2009)
507. Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. (PubMed id 19268443)^{1, 9} Mariani F....Roncucci L. (2009)
508. Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions. (PubMed id 19197984)^{1, 9} Pu X....Wu X. (2009)
509. Regulation of prostaglandin E(2) synthesis in cells d erived from chondrocytes of patients with osteoarthritis. (PubMed id 19802674)^{1, 9} Shimpo H....Ishiguro N. (2009)
510. Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma. (PubMed id 19205707)^{1, 9} Gong Z....Hebert J.R. (2009)
511. Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. (PubMed id 19203995)^{1, 9} Chang K.Y....Chen B.K. (2009)
512. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. (PubMed id 18617679)^{1, 9} Zhao Y....Natarajan V. (2009)
513. R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. (PubMed id 19015962)^{1, 9} Eichele K....Hinz B. (2009)
514. Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signalin g pathway at low-dose H2O2. (PubMed id 19723101)^{1, 9} Park I.J....Park O.J. (2009)
515. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (PubMed id 19638987)^{1, 9} Doherty G.A....Fitzgerald D.J. (2009)
516. Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts. (PubMed id 19616539)^{1, 9} Shih C.H....Chen B.C. (2009)
517. Cyclooxygenase-2 polymorphisms and the risk of esopha geal adeno- or squamous cell carcinoma. (PubMed id 19630103)^{1, 9} Kristinsson J.O....Peters W.H. (2009)
518. Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. (PubMed id 19639178)^{1, 9} Fu Y....Wang T. (2009)
519. Host single nucleotide polymorphisms of MMP-9 -1562/T IMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. (PubMed id 19889076)^{1, 9} Hung K.H....Sheu B.S. (2009)
520. Cyclooxygenase-2 expression in astrocytes and microgl ia in human oligodendroglioma and astrocytoma. (PubMed id 20052522)^{1, 9} Temel S.G. and Kahveci Z. (2009)
521. Cyclooxygenase-2 expression on urothelial and inflammatory cells of cystoscopic biopsies and urine cytology as a possible predictive marker for bladder carcinoma. (PubMed id 19161536)^{1, 9} Moussa M....Swellam T. (2009)
522. The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers. (PubMed id 18720000)^{1, 9} Yoshinaga M....Muto Y. (2009)
523. COX-2 polymorphisms and the risk for head and neck cancer in white patients. (PubMed id 19280666)^{1, 9} Peters W.H....Manni J.J. (2009)
524. COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. (PubMed id 19862936)^{1, 9} Ishiura Y....Myou S. (2009)
525. Cyclic stretch induces cyclooxygenase-2 gene expressi on in vascular endothelial cells via activation of nuclear factor kappa-beta. (PubMed id 19748489)^{1, 9} Zhao H....Rade J.J. (2009)
526. Effect of COX2 -765G>C and c.3618A>G polymorphi sms on the risk and survival of sporadic colorectal cancer. (PubMed id 19468846)^{1, 9} Iglesias D....FernA!ndez-Peralta A.M. (2009)
527. Increased cyclooxygenase-2 expression in juvenile polyposis syndrome. (PubMed id 19124115)^{1, 9} van Hattem W.A....Offerhaus G.J. (2009)
528. Expression of cyclooxygenase-2 in ovarian serous carc inoma: correlation with angiogenesis, nm23 expression and survival. (PubMed id 20099494)^{1, 9} Ozuysal S....Evrensel T. (2009)
529. COX-2 expression is unexpectedly high in viable color ectal mucosal cells: is there life for chemoprophylaxis after VICTOR? (PubMed id 18691269)^{1, 9} McArthur D.R....Williams N. (2009)
530. Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. (PubMed id 19084589)^{1, 9} Jang B.C. (2009)
531. [Effects of cyclooxygenase-2 and proliferating cell n uclear antigen on the onset and development of familial adenomatous polyposis] (PubMed id 19895739)^{1, 9} Zhang Y.H....Li S.R. (2009)
532. Prognostic Significance and Clinicopathological Assoc iations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. (PubMed id 20016751)^{1, 9} Grimminger P.P....Brabender J. (2009)
533. Inhibition of cyclooxygenase-2 down-regulates aromata se activity and decreases proliferation of Leydig tumor cells. (PubMed id 19679653)^{1, 9} Sirianni R....Pezzi V. (2009)
534. [The effect of simultaneously blocking target epiderm al growth factor receptor tyrosine kinase and cyclooxygenase-2 on the growth of NPC cell] (PubMed id 20120857)^{1, 9} Li S.S....Tian Y. (2009)
535. Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. (PubMed id 19127598)^{1, 9} Swami S....Feldman D. (2009)
536. COX-2 limits prostanoid production in activated HUVEC s and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells. (PubMed id 19423863)^{1, 9} Salvado M.D....Redondo J.M. (2009)
537. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)^{1, 9} Lemaitre R.N....Psaty B.M. (2008)
538. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PubMed id 18038187)^{1, 9} Hoeft B....Nieters A. (2008)
539. A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis. (PubMed id 18930197)^{1, 9} Juo S.H....Tsai E.M. (2008)
540. Prognostic significance of cyclooxygenase-2 overexpression in glottic cancer. (PubMed id 18172254)^{1, 9} Sackett M.K....Tetu B. (2008)
541. Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. (PubMed id 18288396)^{1, 9} Goto R....Mori N. (2008)
542. Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium- and protein kinase C zeta-dependent. (PubMed id 18094075)^{1, 9} Jerde T.J....Nakada S.Y. (2008)
543. Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation. (PubMed id 18798061)^{1, 9} Gu P....Cai Y. (2008)
544. Pro-inflammatory gene variants in myocardial infarction and longevity: implications for pharmacogenomics. (PubMed id 18991687)^{1, 9} Listi F....Candore G. (2008)
545. [Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China] (PubMed id 19040046)^{1, 9} Xie X....Liu F. (2008)
546. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. (PubMed id 18471798)^{1, 9} Valdes A.M....Spector T.D. (2008)
547. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. (PubMed id 17884974)^{7, 9} Hinz B....Brune K. (2008)
548. Forced COX-2 expression induces PGE(2) and invasion in immortalized urothelial cells. (PubMed id 18367112)^{1, 9} Gee J....Sabichi A.L. (2008)
549. The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. (PubMed id 18165598)^{1, 9} Gordon S.M....Dionne R.A. (2008)
550. Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. (PubMed id 18441204)^{1, 9} Syeda F....Zhang H. (2008)
551. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. (PubMed id 18378414)^{1, 9} Erdemoglu E....Mungan T. (2008)
552. Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production. (PubMed id 18297687)^{1, 9} Lee S.K....Lee W.J. (2008)
553. Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice. (PubMed id 18611916)^{1, 9} Leung W.K....Sung J.J. (2008)
554. Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. (PubMed id 18817855)^{1, 9} Fujimori K....Urade Y. (2008)
555. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. (PubMed id 18039779)^{1, 9} Banu S.K....Arosh J.A. (2008)
556. Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study. (PubMed id 17350020)^{1, 9} Kohsaka S....Boerwinkle E. (2008)
557. EGFR, HER-2 and COX-2 levels in colorectal cancer. (PubMed id 19102009)^{1, 9} Antonacopoulou A.G....Kalofonos H.P. (2008)
558. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. (PubMed id 18285462)^{1, 9} Doller A....Eberhardt W. (2008)
559. Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells. (PubMed id 18097055)^{1, 9} Blanco A....Munoz-Fernandez M.A. (2008)
560. Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells. (PubMed id 19116446)^{1, 9} Jeong K.J....Lee H.Y. (2008)
561. Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. (PubMed id 18717758)^{1, 9} Zhuang Z.H....Wong B.C. (2008)
562. Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. (PubMed id 19074839)^{1, 9} Zhang W....Siegfried J.M. (2008)
563. 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. (PubMed id 18192694)^{1, 9} Kim E.H....Surh Y.J. (2008)
564. COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. (PubMed id 18462368)^{1, 9} McLean M.H....El-Omar E.M. (2008)
565. COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. (PubMed id 18632220)^{1, 9} Dawsey S.P....Woodson K. (2008)
566. The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. (PubMed id 18571838)^{1, 9} Venerito M....Treiber G. (2008)
567. Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. (PubMed id 18768181)^{1, 9} Rudock M.E....Bowden D.W. (2008)
568. Mannan and peptidoglycan induce COX-2 protein in human PMN via the mammalian target of rapamycin. (PubMed id 17683115)^{1, 9} Fernandez N....Crespo M.S. (2007)
569. Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells. (PubMed id 17133356)^{1, 9} Duggan S.V....Bartlett S.R. (2007)
570. Global gastrointestinal safety profile of etoricoxib and lumiracoxib. (PubMed id 17691997)^{7, 9} Yuan Y. and Hunt R.H. (2007)
571. Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. (PubMed id 17128412)^{1, 9} Mori F....Lazzaro D. (2007)
572. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. (PubMed id 17143555)^{1, 9} Liagre B....Beneytout J.L. (2007)
573. An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. (PubMed id 17604853)^{1, 9} Ansorge N....Schmitz F. (2007)
574. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. (PubMed id 17645803)^{1, 9} Costa V.L....Jeronimo C. (2007)
575. Cyclooxygenase-2 expression in astrocytomas. Relationship with microvascular parameters, angiogenic factors expression and survival. (PubMed id 16868662)^{1, 9} Perdiki M....Patsouris E. (2007)
576. Cardiovascular effects of the selective cyclooxygenase-2 inhibitors. (PubMed id 17612049)^{7, 9} White W.B. (2007)
577. Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. (PubMed id 17265445)^{1, 9} Denkert C....Kristiansen G. (2007)
578. [Effects of RNA interference of COX-2 gene expression on malignant proliferation of A549 cells in vitro] (PubMed id 18478928)^{1, 9} Li W.Y....Zhang C.Y. (2007)
579. In regard to Ishikawa et al.: Cyclooxygenase-2 impairs treatment effect of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis (Int J Radiat Oncol Biol Phys 2006;66:1347-1355). (PubMed id 17544005)^{1, 9} Herrera F.G....Milosevic M. (2007)
580. A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. (PubMed id 17214885)^{1, 9} Cox D.G....Hunter D.J. (2007)
581. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. (PubMed id 17724132)^{1, 9} Ghosh M....Hla T. (2007)
582. CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. (PubMed id 17924829)^{1, 9} Kim S.H....Park H.S. (2007)
583. Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. (PubMed id 17151091)^{1, 9} Tan W....Lin D. (2007)
584. Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. (PubMed id 18085997)^{1, 9} Skarke C....Lotsch J. (2007)
585. Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. (PubMed id 18027256)^{1, 9} Cho N.P....Son H.J. (2007)
586. Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. (PubMed id 17876541)^{1, 9} Mutoh H....Sugano K. (2007)
587. Pharmacodynamic of cyclooxygenase inhibitors in humans. (PubMed id 17164136)^{7, 9} Capone M.L....Patrignani P. (2007)
588. Cyclooxygenase-2 (COX-2) overexpression in meningiomas: real time PCR and immunohistochemistry. (PubMed id 17525632)^{1, 9} Buccoliero A.M....Taddei G.L. (2007)
589. Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms. (PubMed id 17707579)^{1, 9} Deasy B.M....O'Sullivan G.C. (2007)
590. Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study. (PubMed id 17457030)^{1, 9} Fujimi K....Iwaki T. (2007)
591. Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (PubMed id 17460548)^{1, 9} Guo Y....Lin D. (2007)
592. Cyclooxygenase-2 mRNA expression correlates with aromatase expression in human breast cancer. (PubMed id 17657731)^{1, 9} Salhab M....Mokbel K. (2007)
593. Cell proliferation activity unrelated to COX-2 expression in ovarian tumors. (PubMed id 17504375)^{1, 9} Yoshida A....Derchain S.F. (2007)
594. Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer. (PubMed id 17550984)^{1, 9} Siegfried J.M....Stabile L.P. (2007)
595. Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. (PubMed id 17105783)^{1, 9} Astle S....Slater D.M. (2007)
596. Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations. (PubMed id 17624243)^{1, 9} Pannone G....Bufo P. (2007)
597. Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cells. (PubMed id 17405913)^{1, 9} Seo J.H....Kim H. (2007)
598. [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas] (PubMed id 18330256)^{1, 9} Li J....Pan Z. (2007)
599. Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on lung cancer: roles of cyclooxygenase-2. (PubMed id 17342342)^{1, 9} Uemura Y....Taguchi H. (2007)
600. Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. (PubMed id 17434257)^{1, 9} Fernandez-Martinez A.B....Carmena M.J. (2007)
601. Association of COX-2 expression with corresponding active and chronic inflammatory reactions in Barrett's metaplasia and progression to cancer. (PubMed id 17222248)^{1, 9} Ling F.C....Schneider P.M. (2007)
602. Cyclooxygenase-2 polymorphisms in Parkinson's disease. (PubMed id 17171651)^{1, 9} Hakansson A....Nissbrandt H. (2007)
603. Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA. (PubMed id 17016639)^{1, 9} Takaoka K....Urade M. (2006)
604. Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches. (PubMed id 16498361)^{1, 9} Brueggemeier R.W. and Diaz-Cruz E.S. (2006)
605. RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. (PubMed id 17178865)^{1, 9} Chang Y.W....Jakobi R. (2006)
606. Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. (PubMed id 16820091)^{1, 9} Ogino S....Fuchs C.S. (2006)
607. Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction. (PubMed id 16820795)^{1, 9} Norregaard R....Frokiaer J. (2006)
608. Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB. (PubMed id 16212965)^{1, 9} Gomez-Hernandez A....Egido J. (2006)
609. COX-2 induction by heparanase in the progression of breast cancer. (PubMed id 16391819)^{1, 9} Imada T....Naomoto Y. (2006)
610. The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. (PubMed id 16699180)^{1, 9} Eisinger A.L....Jones D.A. (2006)
611. The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia. (PubMed id 16479190)^{1, 9} Colaizzo D....Toni D. (2006)
612. Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. (PubMed id 16414978)^{1, 9} N'Guessan P.D....Schmeck B. (2006)
613. Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. (PubMed id 16371352)^{1, 9} Thiel A....Ristimaki A. (2006)
614. Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta. (PubMed id 16344721)^{1, 9} Siezen C.L....Kampman E. (2006)
615. Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. (PubMed id 16326073)^{1, 9} Duque J....Iniguez M.A. (2006)
616. Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. (PubMed id 16473553)^{1, 9} Ryan E.P....Phipps R.P. (2006)
617. Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. (PubMed id 16879213)^{1, 9} Hegener H.H....Zee R.Y. (2006)
618. Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. (PubMed id 17050798)^{7, 9} Poggi J.C....dos Reis M.L. (2006)
619. Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. (PubMed id 16331686)^{1, 9} Han C....Wu T. (2006)
620. Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. (PubMed id 17003477)^{1, 9} Feldon S.E....Phipps R.P. (2006)
621. Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. (PubMed id 17033106)^{7, 9} Brzozowski T....Pawlik W.W. (2006)
622. NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. (PubMed id 16822500)^{1, 9} Santhi W.S....Pillai M.R. (2006)
623. Proapoptotic activity of NAG-1 is cell type specific and not related to COX-2 expression. (PubMed id 16699947)^{1, 9} Jang T.J....Lee C.H. (2006)
624. Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. (PubMed id 16998585)^{1, 9} Dixon D.A....Zimmerman G.A. (2006)
625. Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. (PubMed id 16926398)^{1, 9} Rydkina E....Sahni S.K. (2006)
626. Inflammation-related gene polymorphisms and colorectal adenoma. (PubMed id 16775170)^{1, 9} Gunter M.J....Rothman N. (2006)
627. Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts. (PubMed id 17097611)^{1, 9} Ogata S....Shirasuna K. (2006)
628. Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors. (PubMed id 16458279)^{1, 9} Orbe J....Paramo J.A. (2006)
629. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. (PubMed id 16681998)^{1, 9} Zhang W.Y....Zhu X.Z. (2006)
630. Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. (PubMed id 16474375)^{1, 9} Milne A.N....Offerhaus G.J. (2006)
631. LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. (PubMed id 16912160)^{1, 9} Upadhyay S....Sidransky D. (2006)
632. Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk. (PubMed id 16808554)^{7, 9} Motsko S.P....Worchel J. (2006)
633. Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. (PubMed id 16682957)^{1, 9} Benoit V....Hainaut P. (2006)
634. Endothelial cell COX-2 expression and activity in hypoxia. (PubMed id 17046322)^{1, 9} Cook-Johnson R.J....James M.J. (2006)
635. IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. (PubMed id 15950941)^{1, 9} Heuze-Vourc'h N....Dubinett S.M. (2005)
636. Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. (PubMed id 16001969)^{1, 9} Alvarez S....Munoz-Fernandez M. (2005)
637. Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells. (PubMed id 15569856)^{1, 9} Kohlstedt K....Fleming I. (2005)
638. Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. (PubMed id 15867220)^{1, 9} Wang W....Damber J.E. (2005)
639. COX-2 inhibitors and metabolism of essential fatty acids. (PubMed id 15990700)^{7, 9} Das U.N. (2005)
640. Prognostic importance of COX-2 expression in patients with colorectal cancer. (PubMed id 16164044)^{1, 9} Yamac D....Koybasioglu F. (2005)
641. Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. (PubMed id 16110762)^{1, 9} Arnoletti J.P....Watson J.C. (2005)
642. Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. (PubMed id 16157291)^{1, 9} Sakurai M....Watanabe K. (2005)
643. High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. (PubMed id 15817909)^{1, 9} Lo C.Y....Luk J.M. (2005)
644. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. (PubMed id 15461587)^{1, 9} Clark S.R....O'Donnell V.B. (2005)
645. Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. (PubMed id 15843495)^{1, 9} Ackerman W.E....Kniss D.A. (2005)
646. Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. (PubMed id 16076963)^{1, 9} Hinz B....Brune K. (2005)
647. Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. (PubMed id 15878334)^{1, 9} Liou J.Y....Wu K.K. (2005)
648. Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. (PubMed id 15870920)^{1, 9} Yoshimoto A....Nakao S. (2005)
649. Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients. (PubMed id 16097073)^{1, 9} Zhang J.T....Yu J. (2005)
650. Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? (PubMed id 16190133)^{7, 9} Das U.N. (2005)
651. In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis. (PubMed id 15943176)^{7, 9} Ozgocmen S....Gudul H. (2005)
652. Effect of specific and non-specific inhibition of COX-2 on renal oxygenation before and after water diuresis. (PubMed id 15692221)^{1, 9} Gilbert S....Epstein F.H. (2005)
653. Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. (PubMed id 16256948)^{1, 9} Rosch S....Hinz B. (2005)
654. Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas. (PubMed id 15067173)^{1, 9} Onguru O....Lloyd R.V. (2004)
655. Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression. (PubMed id 15221958)^{1, 9} Han S....Roman J. (2004)
656. Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta. (PubMed id 15146435)^{1, 9} Morgan M.P....McCarthy G.M. (2004)
657. Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. (PubMed id 15069531)^{1, 9} Hill K.A....Rao M.S. (2004)
658. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. (PubMed id 15050918)^{1, 9} Crawford Y.G....Tlsty T.D. (2004)
659. Comparison of Lornoxicam and Rofecoxib in Patients wi th Activated Osteoarthritis (COLOR Study). (PubMed id 17516707)^{7, 9} Rose P. and Steinhauser C. (2004)
660. Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor. (PubMed id 15838264)^{1, 9} Spinella F....Bagnato A. (2004)
661. Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance. (PubMed id 15484698)^{1, 9} Buccoliero A.M....Taddei G.L. (2004)
662. The correlation between cyclooxygenase-2 expression and hepatocellular carcinogenesis. (PubMed id 15055524)^{1, 9} Sung Y.K....Kim M.K. (2004)
663. Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. (PubMed id 15456329)^{7, 9} Hedner T....Ekbom A. (2004)
664. Role of cyclooxygenase-2 in colorectal cancer. (PubMed id 15000150)^{1, 9} Sinicrope F.A. and Gill S. (2004)
665. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. (PubMed id 15319438)^{1, 9} Hung J.H....Lai M.D. (2004)
666. Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. (PubMed id 15481334)^{7, 9} Gallego-SandA-n S....Abad-Santos F. (2004)
667. Gastrointestinal and hepatic toxicity of selective an d non-selective cyclooxygenase-2 inhibitors in pregnant and non-pregnant rats. (PubMed id 15458776)^{7, 9} Burdan F....Klepacz L. (2004)
668. Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. (PubMed id 14991384)^{1, 9} Yokota O....Kuroda S. (2004)
669. Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. (PubMed id 14984594)^{1, 9} Fogel-Petrovic M....Upham J.W. (2004)
670. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. (PubMed id 15361550)^{1, 9} Hinz B....Brune K. (2004)
671. Hypoxic regulation of angiopoietin-2 expression in endothelial cells. (PubMed id 14702352)^{1, 9} Pichiule P....LaManna J.C. (2004)
672. Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. (PubMed id 13680221)^{1, 9} Shinmura K....Imakiire A. (2004)
673. Expression of COX-2 proteins in gastric mucosal lesions. (PubMed id 14716842)^{1, 9} Yu L.Z....Zhao Z.Q. (2004)
674. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. (PubMed id 14724276)^{1, 9} Nagano S....Bush A.I. (2004)
675. COX-2-dependent stabilization of survivin in non-small cell lung cancer. (PubMed id 14597555)^{1, 9} Krysan K....Dubinett S. (2004)
676. Clinical pharmacology of novel selective COX-2 inhibitors. (PubMed id 14965322)^{7, 9} Tacconelli S....Patrignani P. (2004)
677. Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. (PubMed id 15274307)^{1, 9} Honjo S....Ito H. (2004)
678. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. (PubMed id 14729623)^{1, 9} Denkert C....Hauptmann S. (2004)
679. Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. (PubMed id 15248379)^{1, 9} Sheehan K.M....Murray F.E. (2004)
680. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. (PubMed id 14744769)^{1, 9} Su J.L....Kuo M.L. (2004)
681. [Prognostic role and regulation of cyclooxygenase-2 (COX-2) in ovarian carcinoma] (PubMed id 15478052)^{1, 9} Denkert C. (2004)
682. Valdecoxib: a review. (PubMed id 12852704)^{7, 9} Chavez M.L. and DeKorte C.J. (2003)
683. Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. (PubMed id 12578839)^{1, 9} Sawaoka H....Boutaud O. (2003)
684. Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. (PubMed id 12789263)^{1, 9} Rosell R....Stephens C. (2003)
685. Neutrophil elastase stimulates human airway epithelial cells to produce PGE2 through activation of p44/42 MAPK and upregulation of cyclooxygenase-2. (PubMed id 12832284)^{1, 9} Perng D.W....Lee Y.C. (2003)
686. Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. (PubMed id 14669280)^{1, 9} Roland I.H....Xu X.X. (2003)
687. Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. (PubMed id 14534699)^{1, 9} Ferrandina G....Scambia G. (2003)
688. Expression of cyclooxygenase-2 in human hyperplastic gastric polyps. (PubMed id 14582702)^{1, 9} Bamba H....Fujiwara K. (2003)
689. Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. (PubMed id 12852483)^{7, 9} Cappon G.D....Hurtt M.E. (2003)
690. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. (PubMed id 12626523)^{1, 9} Kamei D....Kudo I. (2003)
691. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. (PubMed id 14530307)^{1, 9} Meyer F....Wilson K.T. (2003)
692. Effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral TA3 supernatant on CAM from chick embryo. (PubMed id 14513718)^{7, 9} ZA_A+iga J....Lemus D. (2003)
693. Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. (PubMed id 12784332)^{1, 9} Denkert C....Hauptmann S. (2003)
694. Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. (PubMed id 12534640)^{7, 9} Kirchheiner J....Brockmoller J. (2003)
695. PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells. (PubMed id 12800228)^{1, 9} Li M.Y....Tan X.Y. (2003)
696. Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. (PubMed id 12782823)^{1, 9} Sung M.W....Kim K.H. (2003)
697. Cyclo-oxygenase-2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans. (PubMed id 12813143)^{1, 9} Langberg H....Kjaer M. (2003)
698. Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. (PubMed id 14517215)^{1, 9} Bradbury D.A....Knox A.J. (2003)
699. Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor. (PubMed id 12824918)^{7, 9} Chen W.S....Yang W.K. (2003)
700. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. (PubMed id 12573452)^{7, 9} Ait-Said F....Hatmi M. (2003)
701. [Pharmacology of cyclooxygenase 2 inhibition] (PubMed id 12705061)^{7, 9} Beubler E. (2003)
702. Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. (PubMed id 12401798)^{1, 9} Liu X.H....Levine A.C. (2002)
703. Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. (PubMed id 12450219)^{1, 9} Xiang Z....Pasinetti G.M. (2002)
704. Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production. (PubMed id 12145315)^{1, 9} Han R. and Smith T.J. (2002)
705. Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. (PubMed id 12444028)^{1, 9} Yang X....Morrell N.W. (2002)
706. 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonami des as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). (PubMed id 11906292)^{1, 9} Hashimoto H....Wakitani K. (2002)
707. Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. (PubMed id 12050157)^{1, 9} Bazan N.G. and Lukiw W.J. (2002)
708. Cyclooxygenase-2 expression by transcription factors in Helicobacter pylori-infected gastric epithelial cells: comparison between HP 99 and NCTC 11637. (PubMed id 12485915)^{1, 9} Seo J.H....Kim K.H. (2002)
709. Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. (PubMed id 11897504)^{1, 9} Richards J.A....Brueggemeier R.W. (2002)
710. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. (PubMed id 11847219)^{1, 9} Han R....Smith T.J. (2002)
711. Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. (PubMed id 12391278)^{1, 9} Wort S.J....Mitchell J.A. (2002)
712. Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells. (PubMed id 12205039)^{1, 9} Pang L....Knox A.J. (2002)
713. Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. (PubMed id 12664576)^{1, 9} Hsi L.C....Eling T.E. (2002)
714. Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. (PubMed id 12208114)^{7, 9} Cipolla G....Frigo G. (2002)
715. Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. (PubMed id 12405290)^{1, 9} Konno H....Nakamura S. (2002)
716. The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity. (PubMed id 12564662)^{7, 9} Tacconelli S....Patrignani P. (2002)
717. Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders. (PubMed id 12397176)^{1, 9} Frungieri M.B....Mayerhofer A. (2002)
718. Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. (PubMed id 12209724)^{1, 9} Ferrandina G....Lauriola L. (2002)
719. Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. (PubMed id 11891188)^{1, 9} Denkert C....Hauptmann S. (2002)
720. Pharmacokinetic and pharmacodynamic aspects of the id eal COX-2 inhibitor: a pharmacologist's perspective. (PubMed id 11695253)^{7, 9} Brune K. and Neubert A. (2001)
721. Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. (PubMed id 11705852)^{1, 9} Bing R.J....Shi S.R. (2001)
722. Rofecoxib: a review of its use in the management of o steoarthritis, acute pain and rheumatoid arthritis. (PubMed id 11398914)^{7, 9} Matheson A.J. and Figgitt D.P. (2001)
723. Aromatase and COX-2 expression in human breast cancers. (PubMed id 11850206)^{1, 9} Brodie A.M....Thijssen J.H. (2001)
724. Evaluation of intravenous parecoxib for the relief of acute post-surgical pain. (PubMed id 11060833)^{7, 9} Jain K.K. (2000)
725. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamid e, valdecoxib: a potent and selective inhibitor of COX-2. (PubMed id 10715145)^{7, 9} Talley J.J....Seibert K. (2000)
726. A comparison of the effects of etodolac and ibuprofen on renal haemodynamics, tubular function, renin, vasopressin and urinary excre tion of albumin and alpha-glutathione-S-transferase in healthy subjects: a plac ebo-controlled cross-over study. (PubMed id 11009046)^{7, 9} Svendsen K.B....Pedersen E.B. (2000)
727. Renal damage induced by the treatment with non-opioid analgesics--theoretical assumption or clinical significance. (PubMed id 11153163)^{7, 9} Fackovcova D....Kriska M. (2000)
728. Sulindac sulfone inhibits K-ras-dependent cyclooxygen ase-2 expression in human colon cancer cells. (PubMed id 11118042)^{7, 9} Taylor M.T....Gerner E.W. (2000)
729. Germline alterations in the cyclooxygenase-2 gene are not associated with the development of extracolonic manifestations in a large swiss familial adenomatous polyposis kindred. (PubMed id 10956391)^{4, 9} Humar B....Dobbie Z. (2000)
730. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. (PubMed id 10485483)^{7, 9} Molina M.A....Sinicrope F.A. (1999)
731. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. (PubMed id 10450786)^{7, 9} Berg J....Stimmeder D. (1999)
732. Ex vivo assay to determine the cyclooxygenase selecti vity of non-steroidal anti-inflammatory drugs. (PubMed id 10372826)^{7, 9} Giuliano F. and Warner T.D. (1999)
733. Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. (PubMed id 10594327)^{7, 9} Kusuhara H....Sugahara K. (1999)
734. [New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase] (PubMed id 9711054)^{7, 9} Stichtenoth D.O....FrAPlich J.C. (1998)
735. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. (PubMed id 9626023)^{7, 9} Cryer B. and Feldman M. (1998)
736. Budesonide epimer R or dexamethasone selectively inhibit platelet- activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. (PubMed id 9520467)^{1, 9} Lukiw W.J.... Bazan N.G. (1998)
737. Cyclooxygenase selectivity and the risk of gastro-int estinal complications of various non-steroidal anti-inflammatory drugs: a clini cal consideration. (PubMed id 9831331)^{7, 9} Kawai S. (1998)
738. Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. (PubMed id 9253954)^{7, 9} Capasso A. and Sorrentino L. (1997)
739. Prognostic significance of cyclooxygenase-2 in cervica l cancer: a meta-analysis. (PubMed id 22729746)¹ Huang M....Zhao X. (2013)
740. Cyclooxygenase-2 up-regulates CCR7 expression via AKT- mediated phosphorylation and activation of Sp1 in breast cancer cells. (PubMed id 22718198)¹ Chuang C.W....Hung W.C. (2013)
741. Increased expression of IL-6 family members in tendon pathology. (PubMed id 22337942)¹ Legerlotz K....Riley G.P. (2012)
742. Prostaglandin H synthase-2-catalyzed oxygenation of 2- arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arac hidonic acid. (PubMed id 22942274)¹ Musee J. and Marnett L.J. (2012)
743. A seven-marker signature and clinical outcome in malig nant melanoma: a large-scale tissue-microarray study with two independent patien t cohorts. (PubMed id 22685558)¹ Meyer S....Wild P.J. (2012)
744. Interplay between membrane lipid peroxidation, transgl utaminase activity, and cyclooxygenase 2 expression in the tissue adjoining to b reast cancer. (PubMed id 21678409)¹ Balestrieri M.L....Stiuso P. (2012)
745. The mRNA stability factor HuR inhibits microRNA-16 tar geting of COX-2. (PubMed id 22049153)¹ Young L.E....Dixon D.A. (2012)
746. Immunoexpression of cyclooxygenase-2 in primary gastri c carcinomas and lymph node metastases. (PubMed id 22371637)¹ Almeida P.R....Ribeiro R.A. (2012)
747. Promoter methylation regulates cigarette smoke-stimula ted cyclooxygenase-2 expression in esophageal squamous cell carcinoma. (PubMed id 22435505)¹ Meng X.Y....Zhang S.T. (2012)
748. Correlation of prostaglandin metabolizing enzymes and serum PGE2 levels with vitamin D receptor and serum 25(OH)2D3 levels in breast a nd ovarian cancer. (PubMed id 22213326)¹ Cordes T....Thill M. (2012)
749. Cyclooxygenase-2 -765 G/C polymorphisms and susceptibi lity to hepatitis B-related liver cancer in Han Chinese population. (PubMed id 21800055)¹ He J....He W. (2012)
750. The expression of MAGE and SSX, and correlation of COX 2, VEGF, and survivin in colorectal cancer. (PubMed id 22287745)¹ Choi J. and Chang H. (2012)
751. The effects of cyclooxygenase-2 gene silencing by siRN A on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan- 2 human pancreatic cancer cells. (PubMed id 22200969)¹ Zhong Y....Zan H. (2012)
752. The influence of transforming growth factor-a, cycloox ygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved i n epithelial-mesenchymal transition on overall survival of patients with gastric cancer. (PubMed id 22582975)¹ Fanelli M.F....Montagnini A.L. (2012)
753. COX2 overexpression is a prognostic marker for Stage I II breast cancer. (PubMed id 21533532)¹ Kim H.S....Noh D.Y. (2012)
754. A novel cytotoxic T lymphocyte epitope analogue with e nhanced activity derived from cyclooxygenase-2. (PubMed id 22686557)¹ Wu Y.H....Qi Y.M. (2012)
755. Expression of COX-2 on Reed-Sternberg cells is an inde pendent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD. (PubMed id 22547578)¹ Mestre F....Rodriguez J. (2012)
756. Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development. (PubMed id 22376259)¹ Kwagyan J....Ashktorab H. (2012)
757. Expression of cyclooxygenase-2 (COX-2) in pituitary tu mours. (PubMed id 22460097)¹ Sokol/owski G....Gol/kowski F. (2012)
758. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chroni c periodontitis in a Chinese population. (PubMed id 22819245)¹ Li G....Chow L.W. (2012)
759. A common single-nucleotide polymorphism in cyclooxygen ase-2 disrupts microRNA-mediated regulation. (PubMed id 21822307)¹ Moore A.E....Dixon D.A. (2012)
760. Association of cyclooxygenase 2 single-nucleotide poly morphisms and hepatocellular carcinoma in Taiwan. (PubMed id 22242948)¹ Chang W.S....Bau D.T. (2012)
761. The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. (PubMed id 22331023)¹ Gal/ecki P....Szemraj J. (2012)
762. Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells. (PubMed id 22885178)¹ Zhu Y....Lance P. (2012)
763. Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. (PubMed id 23105117)¹ Vazquez-Cedeira M. and Lazo P.A. (2012)
764. PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population. (PubMed id 22173719)¹ Daraei A....Mohamadhashem F. (2012)
765. Heterogeneity of COX-2 and multidrug resistance betwee n primary tumors and regional lymph node metastases of gastric cancer. (PubMed id 23052170)¹ Li Y....Wang D. (2012)
766. Differential age- and disease-related effects on the e xpression of genes related to the arachidonic acid signaling pathway in schizoph renia. (PubMed id 22397921)¹ Tang B....Thomas E.A. (2012)
767. The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeu tic target. (PubMed id 22808264)¹ Orlando U.D....Podesta E.J. (2012)
768. Cyclooxygenase-2 (COX-2) up-regulation is a prognostic marker for poor clinical outcome of upper tract urothelial cancer. (PubMed id 22993369)¹ Ke H.L....Bau D.T. (2012)
769. Association between COX-2 rs2745557 polymorphism and p rostate cancer risk: a systematic review and meta-analysis. (PubMed id 22435969)¹ Zhang H....Ma B. (2012)
770. Cyclooxygenase-2 -765G>C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstruct ive pulmonary disease patients. (PubMed id 22100366)¹ Lopez-Campos J.L....Arellano E. (2012)
771. Polymorphisms in cycloxygenase-2 gene and breast cance r prognosis: association between PTGS2 haplotypes and histopathological features . (PubMed id 22037828)¹ Festa-Vasconcellos J.S....Vianna-Jorge R. (2012)
772. CFTR negatively regulates cyclooxygenase-2-PGE(2) posi tive feedback loop in inflammation. (PubMed id 21913191)¹ Chen J....Chan H.C. (2012)
773. Effects of estrogen on endothelial prostanoid producti on and cyclooxygenase-2 and heme oxygenase-1 expression. (PubMed id 22330859)¹ Marcantoni E....Patrignani P. (2012)
774. The DHEA metabolite 7b-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. (PubMed id 22342541)¹ Sandra N....Olivier H. (2012)
775. Cyclooxygenase-2 expression in proliferative Ki-67-pos itive breast cancers is associated with poor outcomes. (PubMed id 22286316)¹ Park B.W....Lee K.S. (2012)
776. Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. -765G>C PTGS2 polymorphism and NMSC risk. (PubMed id 22159575)¹ Cocos R....Raicu F. (2012)
777. Expression of cyclooxygenase-2 in invasive breast carc inomas and its prognostic impact. (PubMed id 22936450)¹ Dhakal H.P....Nesland J.M. (2012)
778. Cyclic AMP increases COX-2 expression via mitogen-acti vated kinase in human myometrial cells. (PubMed id 21854542)¹ Chen L....Johnson M.R. (2012)
779. Simultaneous modulation of COX-2, p300, Akt, and Apaf- 1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. (PubMed id 22335196)¹ Wang J....Deng W. (2012)
780. Astaxanthin attenuates the UVB-induced secretion of pr ostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 pho sphorylation in a ROS depletion-independent manner. (PubMed id 22626465)¹ Terazawa S....Imokawa G. (2012)
781. Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. (PubMed id 22735610)¹ Morita Y....Yoneda T. (2012)
782. AMP-activated protein kinase mediates T cell activatio n-induced expression of FasL and COX-2 via protein kinase C theta-dependent path way in human Jurkat T leukemia cells. (PubMed id 22330070)¹ Lee J.Y....Kang I. (2012)
783. siRNA-mediated knock-down of COX-2 in melanocytes supp resses melanogenesis. (PubMed id 22506937)¹ Kim J.Y....Oh S.H. (2012)
784. Correlation between spiral CT preoperative staging of pancreatic cancer and PTEN and COX-2 expression. (PubMed id 22389271)¹ Chun-Ye Q....Ming G. (2012)
785. Cytoskeletal architecture regulates cyclooxygenase-2 i n human endothelial cells: autocrine modulation by prostacyclin. (PubMed id 22495438)¹ Eligini S....Colli S. (2012)
786. Genetic polymorphism in cyclooxygenase-2 promoter affe cts hepatic inflammation and fibrosis in patients with chronic hepatitis C. (PubMed id 22863264)¹ Miyashita M....Imawari M. (2012)
787. Involvement of COX-2/PGE2 signalling in hypoxia-induce d angiogenic response in endothelial cells. (PubMed id 22050691)¹ Zhao L....Wei X. (2012)
788. Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase- 2 expression in macrophages: the potential role of oleanolic acid. (PubMed id 21681438)¹ Graham V.S....Botham K.M. (2012)
789. Cyclooxygenase-2 expression in central giant cell lesi on of the jaws: an immunohistochemical study. (PubMed id 22042094)¹ Nogueira R.L....Rabenhorst S.H. (2012)
790. Inhibition of cyclooxygenase-2 and inducible nitric ox ide synthase by silymarin in proliferating mesenchymal stem cells: comparison wi th glutathione modifiers. (PubMed id 21710354)¹ Ahmadi-Ashtiani H....Barkhordari E. (2012)
791. Expression levels of cyclooxygenase-2, tumor necrosis factor-a and inducible NO synthase in placental tissue of normal and preeclampti c pregnancies. (PubMed id 22014124)¹ Goksu Erol A.Y....Yildiz S.E. (2012)
792. Glutathione promotes prostaglandin H synthase (cycloox ygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2 a. (PubMed id 22982857)¹ Tsikas D....Stichtenoth D.O. (2012)
793. A randomized phase II of gemcitabine and sorafenib ver sus sorafenib alone in patients with metastatic pancreatic cancer. (PubMed id 21424698)¹ El-Khoueiry A.B....Lenz H.J. (2012)
794. Maximal standardized uptake value on FDG-PET is correl ated with cyclooxygenase-2 expression in patients with lung adenocarcinoma. (PubMed id 22206958)¹ Shimizu K....Nakata M. (2012)
795. Anti-inflammatory potential of an ethyl acetate fracti on isolated from Justicia gendarussa roots through inhibition of iNOS and COX-2 expression via NF-kB pathway. (PubMed id 22063737)¹ Kumar K.S....Helen A. (2012)
796. Notch2-induced COX-2 expression enhancing gastric canc er progression. (PubMed id 21976141)¹ Tseng Y.C....Yeh T.S. (2012)
797. Expression of ezrin, MMP-9, and COX-2 in 50 chordoma s pecimens: a clinical and immunohistochemical analysis. (PubMed id 22228328)¹ Froehlich E.V....Leithner A. (2012)
798. miR-137 is frequently down-regulated in glioblastoma a nd is a negative regulator of Cox-2. (PubMed id 22406049)¹ Chen L....Jiang C. (2012)
799. -765 G->C and -1195 A->G promoter variants of the cycl ooxygenase-2 gene decrease the risk for preeclampsia. (PubMed id 22224631)¹ Gurdol F....Isbir T. (2012)
800. The effect of HIV and HPV coinfection on cervical COX- 2 expression and systemic prostaglandin E2 levels. (PubMed id 22135046)¹ Fitzgerald D.W....Dannenberg A.J. (2012)
801. Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant associ ation of rs20417 with prostate cancer. (PubMed id 22782583)¹ Zhang H.T....Li L. (2012)
802. Sodium arsenite-induced abnormalities in expressions o f Caveolin-1, eNOS, IKKb, and COX-2 in SV-40 immortalized human uroepithelial ce lls and in urothelial carcinomas. (PubMed id 22824620)¹ Liu X.P....Chai C.Y. (2012)
803. Induction of cyclooxygenase (COX)-2 in human vaginal e pithelial cells in response to TLR ligands and TNF-a. (PubMed id 22235849)¹ Joseph T....Doncel G.F. (2012)
804. Galectin-1 promotes lung cancer progression and chemor esistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. (PubMed id 22696230)¹ Chung L.Y....Sun K.H. (2012)
805. IL1b-mediated Stromal COX-2 signaling mediates prolife ration and invasiveness of colonic epithelial cancer cells. (PubMed id 22884582)¹ Zhu Y....Lance P. (2012)
806. Oxidases and oxygenases in regulation of neutrophil re dox pathways in Behcet's disease patients. (PubMed id 21699462)¹ Melikoglu M.A....Aslan M. (2012)
807. Epidermal growth factor-stimulated human cervical can cer cell growth is associated with EGFR and cyclin D1 activation, independent o f COX-2 expression levels. (PubMed id 21946890)¹ Narayanan R....Narayanan B. (2012)
808. Heparanase and cyclooxygenase-2 gene and protein expre ssions during progression of oral epithelial dysplasia to carcinoma. (PubMed id 22575501)¹ Nagatsuka H....Nakajima M. (2012)
809. Interleukin-17 and prostaglandin E2 are involved in fo rmation of an M2 macrophage-dominant microenvironment in lung cancer. (PubMed id 22534817)¹ Liu L....You Z. (2012)
810. No association of nineteen COX-2 gene variants to prec linical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study. (PubMed id 22551325)¹ Lahteela K....Nikkari S.T. (2012)
811. Linoleic acid increases monocyte chemotaxis and adhesi on to human aortic endothelial cells through protein kinase C- and cyclooxygenas e-2-dependent mechanisms. (PubMed id 21840193)¹ Matesanz N....Powell L.A. (2012)
812. Functional polymorphism of cyclooxygenase-2 gene (G-76 5C) in chronic obstructive pulmonary disease patients. (PubMed id 21655952)¹ Pietras T....Gorski P. (2012)
813. Association of the -14C/G MET and the -765G/C COX-2 ge ne polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. (PubMed id 22416915)¹ Sitarek P....Majsterek I. (2012)
814. A genetic variant in 3'-untranslated region of cycloox ygenases-2 gene is associated with risk of gastric cancer in a Chinese populatio n. (PubMed id 22385256)¹ Li H....Shen H. (2012)
815. Prostaglandin EP1 receptor down-regulates expression o f cyclooxygenase-2 by facilitating its proteasomal degradation. (PubMed id 22474323)¹ Haddad A....Barki-Harrington L. (2012)
816. Overexpression of vasoactive intestinal peptide recept ors and cyclooxygenase-2 in human prostate cancer. Analysis of potential prognos tic relevance. (PubMed id 22763881)¹ Fernandez-Martinez A.B....Sanchez-Chapado M. (2012)
817. The value of cyclooxygenase-2 expression in differenti ating between early melanomas and histopathologically difficult types of benign human skin lesions. (PubMed id 22228276)¹ Kuzbicki L./....Chwirot B.W. (2012)
818. The establishment of supramolecular immunobead real-ti me PCR and the identification of Cox-2 as a metastasis-related marker in colorec tal carcinoma. (PubMed id 22710400)¹ Li Z.G....Ding Y.Q. (2012)
819. Interaction between head and neck squamous cell carcin oma cells and fibroblasts in the biosynthesis of PGE2. (PubMed id 22308510)¹ Alcolea S....Vila L. (2012)
820. Regulation of cyclooxygenase-2 expression by heat: a n ovel aspect of heat shock factor 1 function in human cells. (PubMed id 22347460)¹ Rossi A....Santoro M.G. (2012)
821. The role of cyclooxygenase-2 in mechanical ventilation -induced lung injury. (PubMed id 22556158)¹ Robertson J.A....Nonas S.A. (2012)
822. Licofelone inhibits interleukin-18-induced pro-inflamm atory cytokine release and cellular proliferation in human mesangial cells. (PubMed id 22433003)¹ Wu Y.J....Chen H. (2012)
823. Nuclear localization of COX-2 in relation to the expre ssion of stemness markers in urinary bladder cancer. (PubMed id 22577245)¹ Thanan R....Kawanishi S. (2012)
824. Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma. (PubMed id 22553404)¹ Al-Maghrabi J....Al-Ahwal M. (2012)
825. Prognostic role of host cyclooxygenase and cytokine ge notypes in a Caucasian cohort of patients with gastric adenocarcinoma. (PubMed id 23029430)¹ Garcia-Gonzalez M.A....Quintero E. (2012)
826. SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors. (PubMed id 22464751)¹ Rausch S.M....Yang P. (2012)
827. Serum concentrations of cyclooxygenase-2 in patients w ith systemic sclerosis: association with lower frequency of pulmonary fibrosis. (PubMed id 21979415)¹ Bassyouni I.H....Salem T.A. (2012)
828. Is the immunohistochemical expression of proliferation (Ki-67) and apoptosis (Bcl-2) markers and cyclooxigenase-2 (COX-2) related to c arcinogenesis in postmenopausal endometrial polyps? (PubMed id 23301386)¹ Antunes A....Costa-Paiva L. (2012)
829. Noninvasive imaging identifies new roles for cyclooxyg enase-2 in choline and lipid metabolism of human breast cancer cells. (PubMed id 21953546)¹ Shah T....Bhujwalla Z.M. (2012)
830. A local paracrine and endocrine network involving TGFb , Cox-2, ROS, and estrogen receptor b influences reactive stromal cell regulatio n of prostate cancer cell motility. (PubMed id 22593181)¹ Grubisha M.J....Defranco D.B. (2012)
831. The expression of p53 and COX-2 in basal cell carcinom a, squamous cell carcinoma and actinic keratosis cases. (PubMed id 22627629)¹ Karagece Yalcin U. and Seckin S. (2012)
832. Involvement of store-operated calcium signaling in EGF -mediated COX-2 gene activation in cancer cells. (PubMed id 21924350)¹ Wang J.Y....Chang W.C. (2012)
833. EC-SOD induces apoptosis through COX-2 and galectin-7 in the epidermis. (PubMed id 22251572)¹ Lee J.S....Kim T.Y. (2012)
834. Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans. (PubMed id 22859522)¹ Yu G....Pardo A. (2012)
835. Purification and characterization of the recombinant h uman prostaglandin H synthase-2 expressed in Pichia pastoris. (PubMed id 22504626)¹ Kukk K....Samel N. (2012)
836. Cyclooxygenase-2, not microsomal prostaglandin E synth ase-1, is the mechanism for interleukin-1b-induced prostaglandin E2 production a nd inhibition of insulin secretion in pancreatic islets. (PubMed id 22822059)¹ Parazzoli S....Robertson R.P. (2012)
837. Epithelial to mesenchymal transition in cutaneous squa mous cell carcinoma is correlated with COX-2 expression but not with the presenc e of stromal macrophages or CD10-expressing cells. (PubMed id 22460857)¹ Jang T.J. (2012)
838. COX/PGE(2) axis critically regulates effects of LPS on eosinophilia-associated cytokine production in nasal polyps. (PubMed id 22805469)¹ Higaki T....Nishizaki K. (2012)
839. The androgen metabolite, 5a-androstane-3b,17b-diol, de creases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 exp ression, and P-glycoprotein expression in male human brain microvascular endothe lial cells. (PubMed id 23117931)¹ Zuloaga K.L....Handa R.J. (2012)
840. MicroRNA-199a* regulates the expression of cyclooxygen ase-2 in human chondrocytes. (PubMed id 22294637)¹ Akhtar N. and Haqqi T.M. (2012)
841. The P2Y2/Src/p38/COX-2 pathway is involved in the resi stance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells . (PubMed id 22521508)¹ Limami Y....Liagre B. (2012)
842. Clinical relevance of cyclooxygenase-2 and matrix meta lloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue. (PubMed id 22527932)¹ Mohammad M.A....Abdel-Wahab A.H. (2012)
843. Platelet lysate suppresses the expression of lipocalin -type prostaglandin D2 synthase that positively controls adipogenic differentiat ion of human mesenchymal stromal cells. (PubMed id 22698646)¹ Lange C....Scheja L. (2012)
844. Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E_2 production in human endometriotic stromal cells in spheroid culture. (PubMed id 22130322)¹ Yamanaka K....Kitawaki J. (2012)
845. Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection. (PubMed id 22072783)¹ Fang J....Zhu Y. (2012)
846. Inflammatory effect of advanced glycation end products on human meniscal cells from osteoarthritic knees. (PubMed id 21842276)¹ Hiraiwa H....Ishiguro N. (2011)
847. Systematic evaluation of genetic variants in three bi ological pathways on patient survival in low-stage non-small cell lung cancer. (PubMed id 21792076)¹ Pankratz V.S....Yang P. (2011)
848. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. (PubMed id 20950588)¹ Yoshikawa K....Shimada A. (2011)
849. Peritoneal fluid of patients with endometriosis promo tes proliferation of endometrial stromal cells and induces COX-2 expression. (PubMed id 21145050)¹ Liu Y....Yu C. (2011)
850. Increased I95- and I96-desaturase, cyclooxygenase-2, an d lipoxygenase-5 expression and activity are associated with fatty acid and eic osanoid changes in cystic fibrosis. (PubMed id 21605700)¹ Njoroge S.W....Laposata M. (2011)
851. Associations between variants in the cyclooxygenase 2 enzyme gene (PTGS2) and development of benign prostate enlargement. (PubMed id 21481131)¹ St Sauver J.L....Jacobsen S.J. (2011)
852. Interaction between COX-2 G-765C and smoking in relat ion to coronary artery disease in a Chinese Uighur population. (PubMed id 21091235)¹ Xie X....Liu F. (2011)
853. Selective cyclooxygenase-2 (COX-2) inhibitors and bre ast cancer risk. (PubMed id 20724158)⁷ Ashok V....Terry P.D. (2011)
854. High-throughput screen of protein expression levels in duced by cyclooxygenase-2 during influenza a virus infection. (PubMed id 21354125)¹ Liu L....Zhu Y. (2011)
855. A comparative immunohistochemical analysis of COX-2, p53, and Ki-67 expression in keratocystic odontogenic tumors. (PubMed id 21215666)¹ Mendes R.A....van der Waal I. (2011)
856. Expression of HuR, COX-2, and survivin in lung cancer s; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. (PubMed id 21572400)¹ Kim G.Y....Kim Y.W. (2011)
857. All-trans- and 9-cis-retinoic acids activate the huma n cyclooxynase-2 gene: a role for DR1 as RARE or RXRE. (PubMed id 20376700)¹ Han K....Lim H.J. (2011)
858. Nuclear co-localization and functional interaction of COX-2 and HIF-1a characterize bone metastasis of human breast carcinoma. (PubMed id 21069452)¹ Maroni P....Desiderio M.A. (2011)
859. Involvement of P2Y6 receptor in p38 MAPK-mediated COX -2 expression in response to UVB irradiation of human keratinocytes. (PubMed id 21388279)¹ Takai E....Kojima S. (2011)
860. Cyclooxygenase-2 (COX-2) expression in solid pseudopa pillary tumor of the pancreas: a pilot study. (PubMed id 21160376)¹ Kang C.M....Lee W.J. (2011)
861. [Cyclooxygenase-2 overexpression and vascular endothel ial growth factor expression in pharyngeal tissue of patients with OSAHS correla tes with angiogenesis]. (PubMed id 21845875)¹ Zeng H.H....Wang L.X. (2011)
862. Lack of association of the cyclooxygenase 8473 T>C polymorphism with lung cancer: evidence from 9841 subjects. (PubMed id 22292629)¹ Pan F....Zhang Y. (2011)
863. Cyclooxygenase-2 confers growth advantage to syngenei c pancreatic cancer cells. (PubMed id 21343834)¹ Takahashi H....Eibl G. (2011)
864. Cyclooxygenase-2 gene and epithelial ovarian carcinom a risk. (PubMed id 21107726)¹ Agachan Cakmakoglu B....Attar E. (2011)
865. Early proliferation alteration and differential gene expression in human periodontal ligament cells subjected to cyclic tensile stre ss. (PubMed id 20934684)¹ Wang Y....Zhao Z. (2011)
866. Changes in extracellular matrix composition regulate cyclooxygenase-2 expression in human mesangial cells. (PubMed id 21209362)¹ Alique M....RodrA-guez-Puyol D. (2011)
867. Biosynthesis of hemiketal eicosanoids by cross-over o f the 5-lipoxygenase and cyclooxygenase-2 pathways. (PubMed id 21482803)¹ Griesser M....Schneider C. (2011)
868. Cycloxygenase-2 is essential for the survival and prol iferation of gastric cancer cells. (PubMed id 21830126)¹ Ma D....Yang H. (2011)
869. [Expressions and significance of COX-2 and P-gp in hum an hepatocellular carcinoma tissues]. (PubMed id 22409848)¹ Li B....Gong J.P. (2011)
870. Molecular evidence of a (pro)renin/ (pro)renin recept or system in human intrauterine tissues in pregnancy and its association with P GHS-2. (PubMed id 20702505)¹ Pringle K.G....Lumbers E.R. (2011)
871. COX2 expression in prognosis and in prediction to end ocrine therapy in early breast cancer patients. (PubMed id 20358279)¹ van Nes J.G....Bartlett J.M. (2011)
872. [Effects of LPS-induced inflammation on differentiati on of orbital pre-adipocytes in thyroid-associated ophthalmopathy]. (PubMed id 21426847)¹ Yi W.S. and Xu X.L. (2011)
873. COX-2 expression predicts worse breast cancer prognos is and does not modify the association with aspirin. (PubMed id 21728052)¹ Holmes M.D....Tamimi R.M. (2011)
874. [Mechanism of apoptosis of NB4 cells induced by arsen ic trioxide and cyclooxygenase-2 expression]. (PubMed id 21729542)¹ Qin D.B....Wang S.Q. (2011)
875. Role of cyclooxygenase-2 gene polymorphisms in pancre atic carcinogenesis. (PubMed id 22039326)¹ Talar-Wojnarowska R....Malecka-Panas E. (2011)
876. Food contaminant acrylamide increases expression of C ox-2 and nitric oxide synthase in breast epithelial cells. (PubMed id 20713430)¹ Lyn-Cook L.E....Hammons G.J. (2011)
877. Induction of cyclooxygenase-2 expression by hepatitis B virus depends on demethylation-associated recruitment of transcription facto rs to the promoter. (PubMed id 21401943)¹ Yue X....Zhu Y. (2011)
878. Cyclic mechanical stretch downregulates IL-1I^-induced COX-2 expression and PGE(2) production in rheumatoid arthritis fibroblast-like synoviocytes. (PubMed id 20887233)¹ Wang P....Yang L. (2011)
879. Expression of VEGF, VEGFR, EGFR, COX-2 and MVD in cer vical carcinoma, in relation with the response to radio-chemotherapy. (PubMed id 21424032)¹ Nagy V.M....BA8lA8cescu O. (2011)
880. Immunohistochemical expression of cyclooxygenage-2 in melanocytic skin lesions. (PubMed id 21182498)¹ Minami S....Namiki T.S. (2011)
881. Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. (PubMed id 22203921)¹ Balan R....Caruntu I.D. (2011)
882. Apoptosis inducing effect of plumbagin on colonic can cer cells depends on expression of COX-2. (PubMed id 21559086)¹ Subramaniya B.R....Sivasitambaram N.D. (2011)
883. Cyclooxygenase-2 is an independent predictor of poor prognosis in uterine leiomyosarcomas. (PubMed id 21412163)¹ Lee C.H....Song Y.S. (2011)
884. Cyclooxygenase-2 polymorphisms and pancreatic cancer s usceptibility. (PubMed id 21705955)¹ Ozhan G....Daly A.K. (2011)
885. The expression of both peroxisome proliferator-activa ted receptor delta and cyclooxygenase-2 in tissues is associated with poor prog nosis in colorectal cancer patients. (PubMed id 20824502)¹ Yoshinaga M....Muto Y. (2011)
886. Upregulated expression of Toll-like receptor 4 in per ipheral blood of ischaemic stroke patients correlates with cyclooxygenase 2 exp ression. (PubMed id 21236709)¹ Ferronato S....Mazzucco S. (2011)
887. Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. (PubMed id 21042835)¹ AkkA+z H....Ulger Y. (2011)
888. COX2 expression predicts resistance to chemoradiother apy in esophageal squamous cell carcinoma. (PubMed id 21437756)¹ Akutsu Y....Matsubara H. (2011)
889. Human brain endothelial cell-derived COX-2 facilitates extravasation of breast cancer cells across the blood-brain barrier. (PubMed id 22199296)¹ Lee K.Y....Kim H.J. (2011)
890. Nitroarachidonic acid, a novel peroxidase inhibitor o f prostaglandin endoperoxide H synthases 1 and 2. (PubMed id 21266582)¹ Trostchansky A....Rubbo H. (2011)
891. An imbalance of COX level is not related to placental abruption. (PubMed id 21561892)¹ Avagliano L....Bulfamante G.P. (2011)
892. Cyclooxygenase-2 up-regulates vascular endothelial gr owth factor via a protein kinase C pathway in non-small cell lung cancer. (PubMed id 21219643)¹ Luo H....Zhong B. (2011)
893. Interleukin-1I^ induces cyclooxygenase-2 expression an d promotes the invasive ability of human mesenchymal stem cells derived from ov arian endometrioma. (PubMed id 21762900)¹ Kao A.P....Tsai E.M. (2011)
894. Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cycloox ygenase-2. (PubMed id 21867538)¹ ValcA!rcel M....Vidal-Vanaclocha F. (2011)
895. No influence of PTGS2 polymorphisms on response and r emission to antidepressants in major depression. (PubMed id 21168919)¹ Serretti A....Mendlewicz J. (2011)
896. Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon cancer. (PubMed id 21830391)¹ Cha H.J....Park J.W. (2011)
897. Cyclooxygenase-2 in oncogenesis. (PubMed id 21187081)¹ Rizzo M.T. (2011)
898. Clinicopathologic implications of the epidermal growt h factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. (PubMed id 21270615)¹ Giordano G....Merisio C. (2011)
899. HT-29 colorectal cancer cells undergoing apoptosis ov erexpress COX-2 to delay ursolic acid-induced cell death. (PubMed id 21251952)¹ Limami Y....Simon A. (2011)
900. Increased COX-2 expression in human vaginal epithelial cells exposed to nonoxynol-9, a vaginal contraceptive microbicide that failed t o protect women from HIV-1 infection. (PubMed id 21241401)⁷ Zalenskaya I.A....Doncel G.F. (2011)
901. Correlation between COX-2 and APC expression in left versus right-sided human colon cancer. (PubMed id 21737640)¹ Nasir A....Coppola D. (2011)
902. Transgenic mice expressing cyclooxygenase-2 in hepato cytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenes is. (PubMed id 21356386)¹ Llorente Izquierdo C....MartA-n-Sanz P. (2011)
903. Cisplatin decreases renal cyclooxygenase-2 expression and activity in rats. (PubMed id 21272267)⁷ Tusgaard B....Frokiaer J. (2011)
904. Different expression of cyclooxygenase-2 (COX-2) in se lected nonmelanocytic human cutaneous lesions. (PubMed id 22038215)¹ Kuzbicki L./....Chwirot B.W. (2011)
905. Immunohistochemical COX-2 overexpression correlates w ith HER-2/neu overexpression in invasive breast carcinomas: a pilot study. (PubMed id 21371829)¹ A8iriA9 I.M....KapucuoA9lu F.N. (2011)
906. Hodgkin disease risk: Role of genetic polymorphisms a nd gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)¹ Monroy C.M....El-Zein R.A. (2011)
907. Gallbladder cancer predisposition: a multigenic appro ach to DNA-repair, apoptotic and inflammatory pathway genes. (PubMed id 21283657)¹ Srivastava K....Mittal B. (2011)
908. Pivotal role of protein kinase Cdelta in angiotensin II-induced endothelial cyclooxygenase-2 expression: a link to vascular inflamma tion. (PubMed id 21311042)¹ Wong S.L....Huang Y. (2011)
909. Prognostic significance of expression of VEGF and Cox -2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 a nd EGFR. (PubMed id 21031415)¹ Kim T.J....Kang C.S. (2011)
910. Interaction of cyclooxygenase-2 promoter polymorphism s with Helicobacter pylori infection and risk of gastric cancer. (PubMed id 21538574)¹ Zhang X....Miao X. (2011)
911. Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cycloo xygenase 2 and prostaglandin D2 synthase. (PubMed id 21683347)¹ Welter H....Mayerhofer A. (2011)
912. IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression thr ough JAK1 and STAT6. (PubMed id 21277633)¹ Cho W....Choe J. (2011)
913. Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for urinary bladder cancer in North India. (PubMed id 20627335)¹ Gangwar R....Mittal R.D. (2011)
914. Methylation status and overexpression of COX-2 in Tun isian patients with ductal invasive breast carcinoma. (PubMed id 21153458)¹ Karray-Chouayekh S....Mokdad-Gargouri R. (2011)
915. EGFR and COX-2 protein expression in non-small cell l ung cancer and the correlation with clinical features. (PubMed id 21385353)¹ Li F....Wang J. (2011)
916. Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer. (PubMed id 19836060)¹ Bin W....Honglin G. (2011)
917. [The expression and clinical significance of HIF-1I+, COX-2 and E-cadherin in patients with lung adenocarcinoma]. (PubMed id 21426663)¹ Gu S. and Qin J. (2011)
918. [Cyclooxigenase-2 levels are increased in the lung tis sue and bronchial tumors of patients with chronic obstructive pulmonary disease] . (PubMed id 21798652)¹ Roca-Ferrer J....Picado C. (2011)
919. Dihydrotestosterone attenuates hypoxia inducible fact or-1I+ and cyclooxygenase-2 in cerebral arteries during hypoxia or hypoxia with glucose deprivation. (PubMed id 21856910)¹ Zuloaga K.L. and Gonzales R.J. (2011)
920. The interplay between indoleamine 2,3-dioxygenase 1 ( IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer. (PubMed id 21517752)¹ Cesario A....Rutella S. (2011)
921. [Expressions of CD4+ CD25(high) regulatory T cells, TG F-beta 1 and COX-2 in the peripheral blood of prostate cancer patients]. (PubMed id 22049790)¹ Xia T.L....Li L.Y. (2011)
922. Targeting KSHV/HHV-8 latency with COX-2 selective inhi bitor nimesulide: a potential chemotherapeutic modality for primary effusion lym phoma. (PubMed id 21980345)¹ Paul A.G....Chandran B. (2011)
923. Correlations of hypoxia-inducible factor-1I+/hypoxia-i nducible factor-2I+ expression with angiogenesis factors expression and prognosi s in non-small cell lung cancer. (PubMed id 21362301)¹ Wu X.H....Yuan K. (2011)
924. Human cyclooxygenase-2 is a sequence homodimer that f unctions as a conformational heterodimer. (PubMed id 21467029)¹ Dong L....Smith W.L. (2011)
925. Cyclooxygenase-2 expression in lung cancer cells eval uated by immunocytochemistry. (PubMed id 21319320)¹ Koch A....SAPrenson S. (2011)
926. Overproduction of cyclo-oxygenase-2 (COX-2) is involv ed in the resistance to apoptosis in vascular smooth muscle cells from diabetic patients: a link between inflammation and apoptosis. (PubMed id 20957341)¹ Redondo S....Tejerina T. (2011)
927. Upregulation of fibronectin expression by COX-2 is me diated by interaction with ELMO1. (PubMed id 20732417)¹ Yang C. and Sorokin A. (2011)
928. Oxidized low-density lipoprotein-induced periodontal inflammation is associated with the up-regulation of cyclooxygenase-2 and micro somal prostaglandin synthase 1 in human gingival epithelial cells. (PubMed id 21925143)¹ Nagahama Y....Itabe H. (2011)
929. Regulation of bombesin-stimulated cyclooxygenase-2 ex pression in prostate cancer cells. (PubMed id 21745389)¹ Wen X....Hellmich M.R. (2011)
930. Inducible COX-2-dependent apoptosis in human ovarian cancer cells. (PubMed id 21187340)¹ Lin C....Lin H.Y. (2011)
931. Analysis of the 3'UTR of the prostaglandin synthetase- 2 (PTGS-2/COX-2) gene in non-melanoma skin cancer after organ transplantation. (PubMed id 21995456)¹ Gomez-Lira M....Turco A. (2011)
932. Constitutively expressed COX-2 in osteoblasts positiv ely regulates Akt signal transduction via suppression of PTEN activity. (PubMed id 20854947)¹ Li C.J....Ho M.L. (2011)
933. [Effect of valsartan on cyclooxygenase-2 expression in cultured human umbilical vein endothelial cells stimulated by ox-LDL]. (PubMed id 21924077)¹ Jiang L.Q. and Hu D.Y. (2011)
934. [Histone H3 acetylation of tumor necrosis factor-alpha and cyclooxygenase-2 in patients with type 2 diabetes]. (PubMed id 22093778)¹ Hou C....Zhou Z.G. (2011)
935. Tumor cells induce COX-2 and mPGES-1 expression in mi crovascular endothelial cells mainly by means of IL-1 receptor activation. (PubMed id 21277871)¹ CasA^s K....Camacho M. (2011)
936. Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan. (PubMed id 21273602)¹ Wu H.C....Bau D.T. (2011)
937. Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppres sor cells. (PubMed id 21972293)¹ Obermajer N....Kalinski P. (2011)
938. PTGS2 (prostaglandin endoperoxide synthase-2) express ion in term human amnion in vivo involves rapid mRNA turnover, polymerase-II 5' -pausing, and glucocorticoid transrepression. (PubMed id 21385935)¹ Mitchell C....Zakar T. (2011)
939. Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chron ic periodontitis. (PubMed id 21481333)¹ Loo W.T....Li G.R. (2011)
940. Endoplasmic reticulum stress induced by hepatitis B v irus X protein enhances cyclo-oxygenase 2 expression via activating transcripti on factor 4. (PubMed id 21244365)¹ Cho H.K....Cheong J. (2011)
941. Cyclooxygenase 2 and lipoxin A_4 in nasal polyps in cy stic fibrosis. (PubMed id 22185734)¹ Rozsasi A....Keck T. (2011)
942. Human immunodeficiency virus type 1 clade B and C gp12 0 differentially induce neurotoxin arachidonic acid in human astrocytes: implica tions for neuroAIDS. (PubMed id 21491143)¹ Samikkannu T....Nair M.P. (2011)
943. COX-2 expression is correlated with VEGF-C, lymphangi ogenesis and lymph node metastasis in human cervical cancer. (PubMed id 21600223)¹ Liu H....Zhang Y. (2011)
944. miR-143 regulation of prostaglandin-endoperoxidase sy nthase 2 in the amnion: implications for human parturition at term. (PubMed id 21915288)¹ Kim S.Y....Kim C.J. (2011)
945. Docosahexaenoic acid modulates in vitro the inflammat ion of celiac disease in intestinal epithelial cells via the inhibition of cPLA 2. (PubMed id 21421277)¹ Vincentini O....Silano M. (2011)
946. The risk of coronary thrombosis with cyclo-oxygenase- 2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxyge nase-2 gene. (PubMed id 21371074)¹ McGettigan P....Henry D. (2011)
947. Cox-2 gene polymorphism and IL-6 levels in coronary a rtery disease. (PubMed id 21574137)¹ Ol K.K....Isbir T. (2011)
948. Expression of miR-143 reduces growth and migration of human bladder carcinoma cells by targeting cyclooxygenase-2. (PubMed id 21790228)¹ Song T....Hong B. (2011)
949. Globular adiponectin counteracts VCAM-1-mediated mono cyte adhesion via AdipoR1/NF-I_B/COX-2 signaling in human aortic endothelial cel ls. (PubMed id 21900123)¹ Addabbo F....Montagnani M. (2011)
950. Expression of COX-2 and Bcl-2 in primary fallopian tub e carcinoma: correlations with clinicopathologic features. (PubMed id 22038216)¹ Wang F....Zhang X.S. (2011)
951. Smoking and COX-2 functional polymorphisms interact t o increase the risk of gastric cardia adenocarcinoma in Chinese population. (PubMed id 21779349)¹ Zhang X.M....Miao X.P. (2011)
952. Cyclooxygenase-2 and gastric cancer. (PubMed id 22002749)¹ Thiel A....Ristimaki A. (2011)
953. The angiogenic switch for vascular endothelial growth factor-A and cyclooxygenase-2 in prostate carcinoma: correlation with microvesse l density, androgen receptor content and Gleason grade. (PubMed id 21912077)¹ Gyftopoulos K....Papadaki E. (2011)
954. A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy. (PubMed id 21114363)¹ HubA!A8ek J.A....Komers R. (2011)
955. Expression of COX-2, MMP-2 and VEGF in stage II and I II colorectal cancer and the clinical significance. (PubMed id 21661398)¹ Peng Z.H....Pan Z.Z. (2011)
956. Wnt/I^-catenin signaling enhances cyclooxygenase-2 (CO X2) transcriptional activity in gastric cancer cells. (PubMed id 21494638)¹ NuA+ez F....De Ferrari G.V. (2011)
957. Cyclooxygenase-2 expression is not associated with cl inical outcome in synovial sarcoma. (PubMed id 21874258)¹ Carmody Soni E.E....Gibbs C.P. (2011)
958. The Cox-2 -1195 G > A polymorphism and cancer risk : a meta-analysis of 25 case-control studies. (PubMed id 21734230)¹ Tang Z....Shukui Wang . (2011)
959. Cox2 and I^-catenin/T-cell factor signaling intestinal ize human esophageal keratinocytes when cultured under organotypic conditions. (PubMed id 21969813)¹ Kong J....Lynch J.P. (2011)
960. [Expression of COX-2 and PPARg in the livers of patien ts with acute on chronic HBV-related liver failure and their relationship with c linic parameters]. (PubMed id 22152242)¹ Niu Y.H....Zhao Y.R. (2011)
961. Effects of cyclooxygenase-2 on human esophageal squam ous cell carcinoma. (PubMed id 22147962)¹ Zhang L....Zhang S.T. (2011)
962. COX-2 expression in nonepithelial ovarian malignancie s. (PubMed id 21131835)¹ Menczer J....Levi T. (2011)
963. Impact of cyclooxygenase-2 in breast cancer. (PubMed id 22199301)¹ Hoellen F....Thill M. (2011)
964. Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population. (PubMed id 21848701)¹ Zheng J....Zhou Y. (2011)
965. NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis. (PubMed id 21642596)¹ Urso K....Redondo J.M. (2011)
966. Implication of the RAGE-EN-RAGE axis in endometriosis . (PubMed id 20537326)¹ Sharma I....Dhaliwal L.K. (2010)
967. Increased expression of cyclooxygenase-2 is associate d with the progression to cirrhosis. (PubMed id 21179273)¹ Jeong S.W....Kim B.S. (2010)
968. Overexpression of cyclooxygenase-2 as a biomarker in different subtypes of the oral lichenoid disease. (PubMed id 21112532)¹ CortAcs-RamA-rez D.A....Aguirre-Urizar J.M. (2010)
969. A new cyclo-oxygenase-2 gene variant in the Han Chine se population is associated with an increased risk of gastric carcinoma. (PubMed id 21275453)¹ Li Y....Zhang Q. (2010)
970. [Expression and relationship of EBV LMP1, COX-2 and V EGF-C in nasopharyngeal carcinoma]. (PubMed id 20429385)¹ Yi X....Zhao W. (2010)
971. Memory B cells from older people express normal level s of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation. (PubMed id 20889146)¹ Bancos S. and Phipps R.P. (2010)
972. The effect of risedronate on osteogenic lineage is med iated by cyclooxygenase-2 gene upregulation. (PubMed id 20738860)⁷ Valenti M.T....Dalle Carbonare L. (2010)
973. The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes. (PubMed id 20688044)¹ Sudarshan S.R....Liu X. (2010)
974. Factors that contribute to faecal cyclooxygenase-2 mR NA expression in subjects with colorectal cancer. (PubMed id 20145612)¹ Hamaya Y....Kanaoka S. (2010)
975. The proapoptotic BH3-only protein Bim is downregulate d in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE (2) signalling in colorectal adenoma cells. (PubMed id 20348947)¹ Greenhough A....Paraskeva C. (2010)
976. Elevated expression of Foxp3 in tumor-infiltrating Tr eg cells suppresses T-cell proliferation and contributes to gastric cancer prog ression in a COX-2-dependent manner. (PubMed id 19900843)¹ Yuan X.L....Xu D. (2010)
977. mRNA levels of enzymes and receptors implicated in ar achidonic acid metabolism in gliomas. (PubMed id 20382140)¹ De Armas R....Denizot Y. (2010)
978. Cyclooxygenase-2 gene promoter polymorphisms affect s usceptibility to hepatitis C virus infection and disease progression. (PubMed id 20880066)¹ Sakaki M....Imawari M. (2010)
979. Prevalence and clinical relevance of cyclooxygenase-1 and -2 expression in stage IIB cervical adenocarcinoma. (PubMed id 19836124)¹ Jung Y.W....Kim Y.T. (2010)
980. [Expression and significance of COX-2 and S-100 posit ive dendritic cell in laryngeal carcinoma]. (PubMed id 20429377)¹ Qin G....Li W. (2010)
981. [Chinese herbal medicine Jianpi Jiedu Formula down-reg ulates the expression of vascular endothelial growth factor in human gastric cel l line MKN45 induced by Helicobacter pylori by inhibiting cyclooxygenase-2]. (PubMed id 20939988)¹ Liu N.N....Li Q. (2010)
982. Impacts of cytosolic phospholipase A2, 15-prostagland in dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colo rectal cancer. (PubMed id 20635443)¹ Lim S.C....Kim K.J. (2010)
983. ErbB4 promotes cyclooxygenase-2 expression and cell s urvival in colon epithelial cells. (PubMed id 20585313)¹ Frey M.R....Polk D.B. (2010)
984. Role of cyclooxygenase-2 in pathogenesis and preventi on of colorectal cancer. (PubMed id 21088406)¹ Hahn E....Arber N. (2010)
985. Statins inhibit cyclooxygenase-2 and matrix metallopr oteinase-9 in human endothelial cells: anti-angiogenic actions possibly contrib uting to plaque stability. (PubMed id 19946014)¹ Massaro M....De Caterina R. (2010)
986. Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 Polymorphisms on 90-Day Ischemic Stroke Functional Outcome: A Novel Finding. (PubMed id 20472470)¹ Maguire J....Attia J. (2010)
987. Pain control in first-trimester surgical abortion: a systematic review of randomized controlled trials. (PubMed id 20399943)⁷ Renner R.M....Edelman A.B. (2010)
988. The effect of the expression of angiotensin II on ext racellular matrix metalloproteinase inducer (EMMPRIN) in macrophages is mediate d via the AT1/COX-2/PGE2 pathway. (PubMed id 20563831)¹ Yang L.X....Guo C. (2010)
989. Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast canc er cells. (PubMed id 21085606)¹ Maloberti P.M....PodestA! E.J. (2010)
990. Promotion of hematogenous metastatic potentials in hu man KB carcinoma cells with overexpression of cyclooxygenase-2. (PubMed id 20664981)¹ Segawa E....Urade M. (2010)
991. Molecular biomarkers for advanced renal cell carcinom a: implications for prognosis and therapy. (PubMed id 18976937)¹ Kim H.S....Lim H.Y. (2010)
992. The functional -765Ga89C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease. (PubMed id 21124790)¹ de Vries H.S....de Jong D.J. (2010)
993. The cyclooxygenase-2-765C promoter polymorphism prote cts against the development of chronic obstructive pulmonary disease. (PubMed id 20724130)¹ Wu L....Black P.N. (2010)
994. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)¹ Schuurhof A....Janssen R. (2010)
995. [The expression of hepatitis B virus X protein and cy clooxygenase-2 in hepatitis B virus-related hepatocellular carcinoma: correlati on with microangiogenesis and metastasis, and what is the possible mechanism]. (PubMed id 21138631)¹ Liu K.G....Liu J. (2010)
996. Chronic infection during placental malaria is associa ted with up-regulation of cycloxygenase-2. (PubMed id 20144201)¹ Sarr D....Jambou R. (2010)
997. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
998. A pilot study on prostate cancer risk and pro-inflamm atory genotypes: pathophysiology and therapeutic implications. (PubMed id 20388081)¹ Balistreri C.R....Candore G. (2010)
999. Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)¹ Potter C....Wilson A.G. (2010)
1000. Common Genetic Variation, Residential Proximity to Tr affic Exposure, and Left Ventricular Mass: The Multi-Ethnic Study of Atheroscle rosis. (PubMed id 20308035)¹ Van Hee V.C....Kaufman J.D. (2010)
1001. [Detection of EGFR and COX-2 expression by immunohist ochemical method on a tissue microarray section in lung cancer and biological s ignificance]. (PubMed id 20673501)¹ Zhu C....Wang X. (2010)
1002. Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. (PubMed id 20145033)¹ Lo H.W....Ali-Osman F. (2010)
1003. Preferential up-regulation of heparanase and cyclooxy genase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma. (PubMed id 20653782)¹ Sonoda R....Tanaka N. (2010)
1004. Down-regulation of CacyBP is associated with poor pro gnosis and the effects on COX-2 expression in breast cancer. (PubMed id 20878073)¹ Nie F....Ma L. (2010)
1005. Polymorphisms in regulatory regions of cyclooxygenase -2 gene and breast cancer risk in Brazilians: a case-control study. (PubMed id 21059239)¹ Piranda D.N....Vianna-Jorge R. (2010)
1006. Cyclooxygenase-2 (COX-2) polymorphisms and risk of in flammatory bowel disease in a Scottish and Danish case-control study. (PubMed id 20803508)¹ Andersen V....Vogel U. (2010)
1007. Functional polymorphism of cyclooxygenase-2 gene (G-7 65C) in depressive patients. (PubMed id 20588070)¹ GaA8ecki P....Szemraj J. (2010)
1008. Expression of cyclooxygenase-1 and cyclooxygenase-2 i n normal and pathological human oral mucosa. (PubMed id 21478098)¹ Mauro A....Buscemi M. (2010)
1009. Cyclooxygenase-2 and survivin in superficial urotheli al carcinoma of the bladder and correlation with intratumoural microvessel dens ity. (PubMed id 21309483)¹ Yildirim U....Albayrak A. (2010)
1010. Polymorphisms in inflammatory genes, plasma antioxida nts, and prostate cancer risk. (PubMed id 20431935)¹ Zhang J....Kadlubar F.F. (2010)
1011. [Effects of rosiglitazone on the Hep-2 cell prolifera tion, cell cycle and COX-2 expression]. (PubMed id 20545118)¹ Zhang Y....Zhang J. (2010)
1012. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)¹ Johnatty S.E.... . (2010)
1013. Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differen tiation. (PubMed id 20050331)¹ Bernard M.P. and Phipp R.P. (2010)
1014. Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis. (PubMed id 20594217)¹ Dong J....Shen H. (2010)
1015. Kaposi's sarcoma associated herpes virus (KSHV) induc ed COX-2: a key factor in latency, inflammation, angiogenesis, cell survival an d invasion. (PubMed id 20169190)¹ Sharma-Walia N....Chandran B. (2010)
1016. [Expression of COX-2 in different human prostate canc er cell lines and its significance]. (PubMed id 21090342)¹ Zhao J.H....He D.L. (2010)
1017. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiat ion in rectal cancer. (PubMed id 20644561)¹ Ho-Pun-Cheung A....Lopez-Crapez E. (2010)
1018. [Clinical significance and relationship between HIF-1 alpha, COX-2, VEGF and microvessel density expression in laryngeal carcinoma]. (PubMed id 21254648)¹ Cheng W. and Zhou W. (2010)
1019. The effect of a continuous regimen of drospirenone 3 m g/ethinylestradiol 30 microg on Cox-2 and Ki-67 expression in the endometrium. (PubMed id 20063991)⁷ Maia H....Coutinho E.M. (2010)
1020. Snail and Cox-2 expressions are associated with WHO t umor grade and survival rate of patients with gliomas. (PubMed id 19925564)¹ Myung J....Park S.H. (2010)
1021. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
1022. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)¹ Ban H.J....Park K.J. (2010)
1023. Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activa tion of Ras/Raf/ERK/p42 AUF1 pathway. (PubMed id 20489206)¹ Zhai B....Di Battista J.A. (2010)
1024. Co-expression of survivin, c-erbB2, and cyclooxygenas e-2 (COX-2): prognostic value and survival of endometrial cancer patients. (PubMed id 19756737)¹ Lambropoulou M....Chatzaki E. (2010)
1025. Association study of cyclooxygenase 2 single nucleoti de polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. (PubMed id 20944149)¹ Wang C.H....Bau D.T. (2010)
1026. Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase. (PubMed id 20093363)¹ Fujimori K....Urade Y. (2010)
1027. Cyclooxygenase-2 is overexpressed in aberrant crypt f oci of smokers. (PubMed id 20827102)¹ Figueiredo P. and Donato M. (2010)
1028. Circulating cycloxygenase-2 in patients with tobacco- related intraoral squamous cell carcinoma and evaluation of its peptide inhibit ors as potential antitumor agent. (PubMed id 20213098)¹ Kapoor V....Das S.N. (2010)
1029. [Expression and significance of COX-2 and its transcr iption factors NFAT3 and c-Jun in non-small cell lung cancer]. (PubMed id 21081043)¹ Zhao X....He J. (2010)
1030. Role of cyclooxygenase-2 signaling pathway dysfunctio n in unexplained recurrent spontaneous abortion. (PubMed id 20819509)¹ Wang Y....Lin Q.D. (2010)
1031. Genetic variation in prostaglandin E2 synthesis and s ignaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PubMed id 20086108)¹ Poole E.M....Ulrich C.M. (2010)
1032. The value of MG7-Ag and COX-2 for predicting malignan cy in gastric precancerous lesions. (PubMed id 20446925)¹ Hong L....Fan D. (2010)
1033. Caveolin-1 facilitates cyclooxygenase-2 protein degra dation. (PubMed id 19960513)¹ Chen S.F....Shyue S.K. (2010)
1034. Association of the 8473T>C cyclooxygenase-2 (COX-2 ) gene polymorphism with lung cancer risk in Asians. (PubMed id 21198273)¹ Liu F....Yang X. (2010)
1035. Citral, a component of lemongrass oil, activates PPAR I+ and I^ and suppresses COX-2 expression. (PubMed id 20656057)¹ Katsukawa M....Inoue H. (2010)
1036. Contribution of reactive oxygen species to migration/ invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activat ion. (PubMed id 19804834)¹ Chiu W.T....Chen Y.C. (2010)
1037. Role of HuR and p38MAPK in ultraviolet B-induced post -transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT. (PubMed id 19917608)¹ Fernau N.S....Klotz L.O. (2010)
1038. COX-2 activation is associated with Akt phosphorylati on and poor survival in ER-negative, HER2-positive breast cancer. (PubMed id 21078168)¹ Glynn S.A....Ambs S. (2010)
1039. Evidence for a spatial and temporal regulation of pro staglandin-endoperoxide synthase 2 expression in human amnion in term and prete rm parturition. (PubMed id 20519349)¹ Lee D.C....Kim C.J. (2010)
1040. Upregulation of cyclooxygenase-2 by 4-nonylphenol is mediated through the cyclic amp response element activation pathway. (PubMed id 20954072)¹ Han E.H....Jeong H.G. (2010)
1041. The -765C allele of the cyclooxygenase-2 gene as a po tential risk factor of colorectal cancer: a meta-analysis. (PubMed id 20808059)¹ Cao H....Li S.L. (2010)
1042. Cyclooxygenase-2 signaling in vocal fold fibroblasts. (PubMed id 20717945)¹ Branski R.C....Kraus D.H. (2010)
1043. Relationship between cyclooxygenase-2 and human epide rmal growth factor receptor 2 in vascular endothelial growth factor C up-regula tion and lymphangiogenesis in human breast cancer. (PubMed id 20608938)¹ Bhattacharjee R.N....Lala P.K. (2010)
1044. Synergistic effect of 5-fluorouracil and the flavanoi d oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mi ce. (PubMed id 19585117)¹ Zhao L....Guo Q.L. (2010)
1045. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)¹ Romero R....Menon R. (2010)
1046. [Relationship between single nucleotide polymorphisms in the promoter of COX-2 gene and hereditariness to NAFLD.] (PubMed id 21059296)¹ Cao M.B....Dong L. (2010)
1047. Increasing CD44+/CD24(-) tumor stem cells, and upregu lation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis. (PubMed id 21044318)¹ Wang K.H....Tsai E.M. (2010)
1048. Honokiol inhibits gastric tumourigenesis by activatio n of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-act ivated receptor-gamma and COX-2-dependent signals. (PubMed id 20649594)¹ Liu S.H....Sheu M.L. (2010)
1049. Cyclooxygenase-2 gene and lung carcinoma risk. (PubMed id 20645029)¹ Coskunpinar E....Agachan B. (2010)
1050. Genetic variants in inflammation-related genes are as sociated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)¹ Hildebrandt M.A....Wu X. (2010)
1051. Sphingosine interaction with acidic leucine-rich nucl ear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX )-2 expression in human endothelial cells. (PubMed id 20558741)¹ Habrukowich C....Hla T. (2010)
1052. Initial response of endothelial cells to acute stimul ation with a lipid component: increase cyclooxygenase activity by induction of COX-2 through activation of tyrosine kinase. (PubMed id 21299081)¹ Plasen D....Thaworn A. (2010)
1053. Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non- small cell lung cancer. (PubMed id 20592629)¹ Wu Y.C....Hsueh C.T. (2010)
1054. PharmGKB summary: very important pharmacogene informa tion for PTGS2. (PubMed id 21063235)¹ Thorn C.F....Altman R.B. (2010)
1055. Pooled analysis of the association of PTGS2 rs5275 po lymorphism and NSAID use with invasive ovarian carcinoma risk. (PubMed id 20559705)¹ Lurie G....Goodman M.T. (2010)
1056. Cyclooxygenase-2 gene polymorphisms and risk of cervi cal cancer in a North Indian population. (PubMed id 20686383)¹ Pandey S....Mittal B. (2010)
1057. The MIF homologue D-dopachrome tautomerase promotes C OX-2 expression through I^-catenin-dependent and -independent mechanisms. (PubMed id 21071513)¹ Xin D....Mitchell R.A. (2010)
1058. [Relationship of cyclooxygenase-2 and multidrug resis tance associated factors to chemosensitivities in gastrointestinal carcinomas] (PubMed id 20369487)¹ Tan B.B....Wang D. (2010)
1059. Association of -765G>C polymorphism of the COX-2 g ene with recurrent embryo implantation failure in Southern Chilean women. (PubMed id 20599859)¹ Salazar L.A....GuzmA!n N. (2010)
1060. Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. (PubMed id 20538124)¹ St Germaine C.G....Brophy J.M. (2010)
1061. Enhanced expression of proproliferative and antiapopt otic genes in ulcerative colitis-associated neoplasia. (PubMed id 20027603)¹ Svec J....PA!cha J. (2010)
1062. Correlation between inducible nitric oxide synthase a nd cyclooxygenase-2 expression in human colorectal adenocarcinoma: a cross-sect ional study. (PubMed id 20069397)¹ Habibollahi P....Ostad S.N. (2010)
1063. Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. (PubMed id 19933775)¹ Chen W....Lin Y. (2010)
1064. Cox-2 and IL-10 polymorphisms and association with sq uamous cell carcinoma of the head and neck in a Korean sample. (PubMed id 20592893)¹ Jeong S.W....Shin H.D. (2010)
1065. Prostaglandin-endoperoxide synthase genes COX1 and CO X2 - novel modifiers of disease severity in cystic fibrosis patients. (PubMed id 20720307)¹ Czerska K....Bal J. (2010)
1066. Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. (PubMed id 20034614)¹ Su K.P....Pariante C.M. (2010)
1067. Involvement of Ras and AP-1 in Helicobacter pylori-in duced expression of COX-2 and iNOS in gastric epithelial AGS cells. (PubMed id 19495976)¹ Cho S.O....Kim H. (2010)
1068. Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis. (PubMed id 21086572)¹ Liu J.L....Xing L.L. (2010)
1069. Analysis of common germline polymorphisms as prognost ic factors in patients with lymph node-positive breast cancer. (PubMed id 20204402)¹ Knechtel G....Langsenlehner U. (2010)
1070. Reciprocal correlation between the expression of cycl ooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. (PubMed id 20582552)¹ Jang T.J....Lee K.S. (2010)
1071. Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. (PubMed id 20160714)¹ Garrity-Park M.M....Smyrk T.C. (2010)
1072. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. (PubMed id 19621391)¹ Uddin S....Munkarah A. (2010)
1073. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)¹ Liu C.Y....Christiani D.C. (2010)
1074. Genetic variation in 3-hydroxy-3-methylglutaryl CoA r eductase modifies the chemopreventive activity of statins for colorectal cancer . (PubMed id 20403997)¹ Lipkin S.M....Gruber S.B. (2010)
1075. Association of COX-2 promoter polymorphism with gastr ointestinal tract cancer in Iran. (PubMed id 20809087)¹ Biramijamal F....Shamimi K. (2010)
1076. Epigenetic change in E-cadherin and COX-2 to predict chronic periodontitis. (PubMed id 21047437)¹ Loo W.T....Chow L.W. (2010)
1077. TNF superfamily gene polymorphism as prognostic facto r in early breast cancer. (PubMed id 19890662)¹ Jung J.H....Park H.Y. (2010)
1078. COX-2 polymorphisms and colorectal cancer risk: a str ategy for chemoprevention. (PubMed id 20075740)¹ Pereira C....Dinis-Ribeiro M. (2010)
1079. The (-765 G->C) promoter variant of the COX-2/PTGS 2 gene is associated with a lower risk for end-stage hip and knee osteoarthriti s. (PubMed id 20378913)¹ Schneider E.M....Brenner R.E. (2010)
1080. Relationship between COX-2 and cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma. (PubMed id 21157974)¹ Huang J.X....Salminen E. (2010)
1081. Influence of cyclooxygenase-2 (COX-2) gene promoter p olymorphism at position -765 on skin cancer after renal transplantation. (PubMed id 20445548)¹ Aubin F....Ducloux D. (2010)
1082. Receptor and enzyme expression for prostanoid metabol ism in colorectal cancer related to tumor tissue PGE2. (PubMed id 20043083)¹ Gustafsson A....Lundholm K. (2010)
1083. HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression. (PubMed id 19940973)¹ Lim W....Cho H. (2010)
1084. [Cyclooxygenase-2 polymorphisms and bronchoalveolar l avage cellularity of sarcoidosis]. (PubMed id 21416732)¹ LA^pez-Campos J.L....Montes-Worboys A. (2010)
1085. Cyclooxygenase-2 enhances alpha2beta1 integrin expres sion and cell migration via EP1 dependent signaling pathway in human chondrosar coma cells. (PubMed id 20178602)¹ Liu J.F....Tang C.H. (2010)
1086. Expression of vitamin D receptor (VDR), cyclooxygenas e-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and m alignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostagla ndin E2 (PGE2) serum level in ovarian cancer patients. (PubMed id 20304053)¹ Thill M....Becker S. (2010)
1087. Stable transfection of estrogen receptor-alpha suppre sses expression of cyclooxygenase-2 and vascular endothelial growth factor-C in MDA-MB-231 breast cancer cells. (PubMed id 20819530)¹ Zhang H....Wang S.M. (2010)
1088. COX-2-mediated regulation of VEGF-C in association wi th lymphangiogenesis and lymph node metastasis in lung cancer. (PubMed id 20830783)¹ Liu H....Zhao L. (2010)
1089. Identification of cyclooxygenase-2 as a major actor o f the transcriptomic adaptation of endothelial and tumor cells to cyclic hypoxi a: effect on angiogenesis and metastases. (PubMed id 20068092)¹ Daneau G....Feron O. (2010)
1090. Alteration of PTGS2 promoter methylation in chronic p eriodontitis. (PubMed id 20042743)¹ Zhang S....Offenbacher S. (2010)
1091. A haplotype of cyclooxygenase-2 gene is associated wi th idiopathic pulmonary fibrosis. (PubMed id 21319594)¹ Xaubet A....Picado C. (2010)
1092. Inducible cyclooxygenase released prostaglandin E2 mo dulates the severity of infection caused by Streptococcus pyogenes. (PubMed id 20644176)¹ Goldmann O....Medina E. (2010)
1093. Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas. (PubMed id 20846124)¹ Legan M. (2010)
1094. Study on the association of COX-2 genetic polymorphis ms with risk of gastric cancer in high incidence Hexi area of Gansu province in China. (PubMed id 20364406)¹ Ke-Xiang Z....Tao L. (2010)
1095. Association of haplotypes of inflammation-related gen es with gastric preneoplastic lesions in African Americans and Caucasians. (PubMed id 20473875)¹ Zabaleta J....Ochoa A.C. (2010)
1096. The timing of perinatal hypoxia/ischemia events in te rm neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events. (PubMed id 20626887)¹ Riezzo I....Fineschi V. (2010)
1097. Epidermal growth factor increases prostaglandin E2 pr oduction via ERK1/2 MAPK and NF-kappaB pathway in fibroblast like synoviocytes from patients with rheumatoid arthritis. (PubMed id 19680656)¹ Nah S.S....Baik H.H. (2010)
1098. Prognostic evaluation of COX-2 expression in renal ce ll carcinoma. (PubMed id 20683050)¹ Kankuri-Tammilehto M.K....Salminen E.K. (2010)
1099. Cyclooxygenase-2 (COX-2) is the key event in pathophy siology of Barrett's esophagus. Lesson from experimental animal model and human subjects. (PubMed id 20814068)¹ Majka J....Brzozowski T. (2010)
1100. Feedback amplification of fibrosis through matrix sti ffening and COX-2 suppression. (PubMed id 20733059)¹ Liu F....Tschumperlin D.J. (2010)
1101. Hypermethylation of RARI^2 correlates with high COX-2 expression and poor prognosis in patients with colorectal carcinoma. (PubMed id 20571967)¹ Miladi-Abdennadher I....Mokdad-Gargouri R. (2010)
1102. Embryonic expression of cyclooxygenase-2 causes malfo rmations in axial skeleton. (PubMed id 20236942)¹ Shim M....Eling T. (2010)
1103. Genetic variants in COX-2, non-steroidal anti-inflamm atory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study. (PubMed id 20676755)¹ Brasky T.M....Freudenheim J.L. (2010)
1104. Cetuximab as second-line therapy in patients with met astatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S 0415). (PubMed id 20631636)¹ Gold P.J....Blanke C.D. (2010)
1105. COX-2 expression in human breast carcinomas: correlat ion with clinicopathological features and prognostic molecular markers. (PubMed id 20536410)¹ Miglietta A....Bocca C. (2010)
1106. [Correlation of cyclooxygenase 2 expression with micr olymphatic density and its clinical significance]. (PubMed id 20878581)¹ Zhou B.T....Huang Y.J. (2010)
1107. Structural basis of fatty acid substrate binding to c yclooxygenase-2. (PubMed id 20463020)⁷ Vecchio A.J....Malkowski M.G. (2010)
1108. Functional variants of COX-2 and risk of tobacco-rela ted oral squamous cell carcinoma in high-risk Asian Indians. (PubMed id 20620096)¹ Mittal M....Das S.N. (2010)
1109. Pre-surgical study of the biological effects of the s elective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer. (PubMed id 20697803)¹ Martin L.A....Dowsett M. (2010)
1110. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. (PubMed id 20810665)¹ Duggan K.C....Marnett L.J. (2010)
1111. Association study of interferon-I^, cytosolic phosphol ipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease. (PubMed id 20808133)¹ FehAcr A....Janka Z. (2010)
1112. Use of aspirin and other nonsteroidal antiinflammator y medications in relation to prostate cancer risk. (PubMed id 20688905)¹ Salinas C.A....Stanford J.L. (2010)
1113. Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells. (PubMed id 20631257)¹ Wang X....Davie J.R. (2010)
1114. COX-2 is associated with periodontitis in Europeans. (PubMed id 20177132)¹ Schaefer A.S....Schreiber S. (2010)
1115. Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients. (PubMed id 20530427)¹ Liu C.J....Bau D.T. (2010)
1116. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)¹ Romero R....Menon R. (2010)
1117. [Small interfering RNA-mediated COX-2 gene silencing inhibits the proliferation and migration of human ovarian cancer cell line CAOV -3] (PubMed id 19861248)¹ Su Y.J....Bao J. (2009)
1118. Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. (PubMed id 19221469)¹ Fendri A....Mokdad-Gargouri R. (2009)
1119. Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53. (PubMed id 19465063)¹ Choi E.M....Han J.A. (2009)
1120. Toll-like receptor signaling pathway variants and pro state cancer mortality. (PubMed id 19505919)¹ Stark J.R....Kraft P. (2009)
1121. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)¹ Mavaddat N....Pharoah P.D. (2009)
1122. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)¹ Shen M....Lan Q. (2009)
1123. Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. (PubMed id 19338579)⁷ Ottonello L....Dallegri F. (2009)
1124. A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. (PubMed id 19272160)¹ Annabi B....BAcliveau R. (2009)
1125. Identification of a new broad-spectrum CD8+ T cell ep itope from over-expressed antigen COX-2 in esophageal carcinoma. (PubMed id 19423214)¹ Gao Y.F....Wang X.Y. (2009)
1126. High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells. (PubMed id 18802697)¹ Herfs M....Delvenne P. (2009)
1127. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)¹ Hosgood H.D....Lan Q. (2009)
1128. Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction. (PubMed id 18843292)¹ Tjiu J.W....Jee S.H. (2009)
1129. Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts. (PubMed id 19056642)¹ Corella D....Estruch R. (2009)
1130. Weak expression of cyclooxygenase-2 is associated wit h poorer outcome in endemic nasopharyngeal carcinoma: analysis of data from ran domized trial between radiation alone versus concurrent chemo-radiation (SQNP-0 1). (PubMed id 19591688)¹ Loong S.L....Tan T.W. (2009)
1131. Classification using hierarchical clustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression. (PubMed id 18997734)¹ Liu M....Konishi I. (2009)
1132. Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. (PubMed id 18790560)¹ Al-Salihi M.A....Topham M.K. (2009)
1133. Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. (PubMed id 19289254)¹ Lee K.S....Kim S.H. (2009)
1134. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of co lorectal cancer in a Danish prospective case-cohort study. (PubMed id 19930591)¹ Andersen V....Vogel U. (2009)
1135. Expression of retinoic acid receptor beta in dermatof ibrosarcoma protuberans. (PubMed id 19469866)¹ Xiaoli Z. and Qinhe F. (2009)
1136. Vascular endothelial growth factor-C (VEGF-C) promote s angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. (PubMed id 19825968)¹ Chien M.H....Kuo M.L. (2009)
1137. Positive correlation between cyclooxygenase-2 and ABC -transporter expression in non-Hodgkin's lymphomas. (PubMed id 19885582)¹ Szczuraszek K....Surowiak P. (2009)
1138. Anti-inflammatory and anticarcinogenic effect of geni stein alone or in combination with capsaicin in TPA-treated rat mammary glands or mammary cancer cell line. (PubMed id 19723084)¹ Hwang J.T....Park O.J. (2009)
1139. Design, synthesis, and in-vivo evaluation of 4,5-diar yloxazole as novel nonsteroidal anti-inflammatory drug. (PubMed id 19952416)⁷ Zhou X.P....Qu S.C. (2009)
1140. VEGF gene expression in adult human thymus fat: a cor relative study with hypoxic induced factor and cyclooxygenase-2. (PubMed id 20011601)¹ Tinahones F....El Bekay R. (2009)
1141. Role of inflammation gene polymorphisms on pain sever ity in lung cancer patients. (PubMed id 19773451)¹ Reyes-Gibby C.C....Shete S. (2009)
1142. Cyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer. (PubMed id 19289707)¹ Nakagawa T....Nibu K. (2009)
1143. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. (PubMed id 19661089)¹ Hussain S.K....Zhang Z.F. (2009)
1144. Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans. (PubMed id 19741338)¹ Santovito D....Cipollone F. (2009)
1145. G-765C COX-2 gene promoter polymorphism and risk of a therosclerosis after kidney transplantation. (PubMed id 19920789)¹ Courivaud C....Thervet E. (2009)
1146. Cyclooxygenase-2 expression in cervical intraepitheli al neoplasia. (PubMed id 19723044)¹ Kim K....Song Y.S. (2009)
1147. [Association between promoter methylation of cyclooxy genase-2 and expression, and precancerous gastric lesions in a high-risk popula tion] (PubMed id 19954066)¹ Nie X.R....You W.C. (2009)
1148. Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma. (PubMed id 19346994)¹ Hermanova M....Dite P. (2009)
1149. Triggering of DC migration by dengue virus stimulatio n of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation. (PubMed id 19862774)¹ Wu W.L....Lai J.H. (2009)
1150. Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. (PubMed id 19219602)¹ Kim J.G....Jun S.H. (2009)
1151. Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. (PubMed id 19487460)¹ Coward W.R....Pang L. (2009)
1152. Peroxide-induced radical formation at TYR385 and TYR5 04 in human PGHS-1. (PubMed id 19433337)¹ Rogge C.E....Tsai A.L. (2009)
1153. Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta. (PubMed id 19169273)