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PTGS2 Gene

protein-coding   GIFtS: 74
GCID: GC01M186640

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H...

  See PTGS2-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase And
Cyclooxygenase)1 2
Prostaglandin H2 Synthase 22 3     PHS-22
COX-22 3     Cyclooxygenase 2b2
COX22 3     hCox-22
PGHS-22 3     Prostaglandin G/H Synthase 22
PGH Synthase 22 3     Cyclooxygenase-23
PHS II2 3     Prostaglandin-Endoperoxide Synthase 23
EC 8     EC 1.14.998

External Ids:    HGNC: 96051   Entrez Gene: 57432   Ensembl: ENSG000000737567   OMIM: 6002625   UniProtKB: P353543   

Export aliases for PTGS2 gene to outside databases

Previous GC identifiers: GC01M184166 GC01M182068 GC01M183160 GC01M183879 GC01M183372 GC01M184907 GC01M157875

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGS2 Gene:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin
biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive
PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene
encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible
for the prostanoid biosynthesis involved in inflammation and mitogenesis. (provided by RefSeq, Feb 2009)

GeneCards Summary for PTGS2 Gene:
PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)) is a protein-coding gene. Diseases associated with PTGS2 include bile duct cysts, and protoplasmic astrocytoma. GO annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is PTGS1.

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354
Function: Critical component of colonic mucosal wound repair (By similarity). Mediates the formation of
prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for
prostanoid signaling in activity-dependent plasticity

summary for PTGS2 Gene:
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is
expressed in cells in three isoforms: COX-1, COX-2 and COX-3. COX-1 (constitutive) and COX-2 (inducible)
isoforms catalyze the rate-limiting step of prostaglandin production and are the targets of non-steroidal
anti-inflammatory drugs. COX-3 does not appear to be involved in inflammatory processes, but seems to be
involved in pain and fever. COX-3 is thought to be derived through the retention of the highly structured G
+ C-rich intron 1 of the COX-1 gene.

Gene Wiki entry for PTGS2 Gene

PharmGKB "VIP" summary for PTGS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGS2 gene promoter:
         AP-1   ATF-2   POU6F1 (c2)   STAT5A   CREB   deltaCREB   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTGS2 promoter sequence
   Search Chromatin IP Primers for PTGS2

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2-q25.3   Ensembl cytogenetic band:  1q31.1   HGNC cytogenetic band: 1q25.2-q25.3

PTGS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M186640:  view genomic region     (about GC identifiers)

186,640,923 bp from pter      End:
186,649,559 bp from pter
8,637 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354 (See protein sequence)
Recommended Name: Prostaglandin G/H synthase 2 precursor  
Size: 604 amino acids; 68996 Da
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)
Subunit: Homodimer (By similarity)
Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase
Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin
1 PDB 3D structure from and Proteopedia for PTGS2:
1V0X (3D)    
Secondary accessions: A8K802 Q16876

Explore the universe of human proteins at neXtProt for PTGS2: NX_P35354

Explore proteomics data for PTGS2 at MOPED

Post-translational modifications: 

  • S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues
    in addition to Cys-5611
  • Glycosylation2 at Asn53, Asn130, Asn396, Asn580
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTGS2 (P35354) (see all 30)

    See PTGS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000954.1  
    ENSEMBL proteins: 
     ENSP00000356438   ENSP00000454130  
    Reactome Protein details: P35354

    PTGS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PTGS2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PTGS2
    GenScript Custom Purified and Recombinant Proteins Services for PTGS2
    Novus Biologicals PTGS2 Proteins
    Novus Biologicals PTGS2 Lysates
    Sino Biological Recombinant Protein for PTGS2
    Sino Biological Cell Lysate for PTGS2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGS2

    Search eBioscience for Proteins for PTGS2 

    antibodies-online proteins for PTGS2 (10 products) 

    antibodies-online peptides for PTGS2

    Search GeneTex for Proteins for PTGS2 

    PTGS2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGS2
    R&D Systems Antibodies for PTGS2 (COX-2)
    Cell Signaling Technology (CST) Antibodies for PTGS2  (COX-2)
    OriGene Antibodies for PTGS2
    OriGene Custom Antibody Services for PTGS2
    Novus Biologicals PTGS2 Antibodies
    Abcam antibodies for PTGS2
    Cloud-Clone Corp. Antibodies for PTGS2
    ThermoFisher Antibodies for PTGS2
    antibodies-online antibodies for PTGS2 (168 products) 

    GeneTex Antibodies for PTGS2:  
                        PTGS2 Antibodies

    PTGS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTGS2
    R&D Systems ELISAs for PTGS2 (COX-2)         (see all)
    GenScript Custom Assay Services for PTGS2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PTGS2 (COX-2)
    Enzo Life Sciences assays for PTGS2
    Cloud-Clone Corp. ELISAs for PTGS2
    Cloud-Clone Corp. CLIAs for PTGS2
    Search eBioscience for ELISAs for PTGS2 
    antibodies-online kits for PTGS2 (57 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    IUPHAR Guide to PHARMACOLOGY protein family classification: COX-2

    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR010255 Haem_peroxidase
     IPR019791 Haem_peroxidase_animal_subgr
     IPR002007 Haem_peroxidase_animal

    Graphical View of Domain Structure for InterPro Entry P35354

    ProtoNet protein and cluster: P35354

    3 Blocks protein domains:
    IPB002007 Animal haem peroxidase signature
    IPB006210 Type I EGF
    IPB010255 Haem peroxidase

    UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354
    Similarity: Belongs to the prostaglandin G/H synthase family
    Similarity: Contains 1 EGF-like domain

    Find genes that share domains with PTGS2           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGH2_HUMAN, P35354
    Function: Critical component of colonic mucosal wound repair (By similarity). Mediates the formation of
    prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for
    prostanoid signaling in activity-dependent plasticity
    Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=16.2 uM for arachidonate (in absence of sodium nitroprusside
    NO donor); KM=17.0 uM for arachidonate (in presence of sodium nitroprusside NO donor); Vmax=81.3 nmol/min/mg
    enzyme (in absence of sodium nitroprusside NO donor); Vmax=132 nmol/min/mg enzyme (in absence of sodium
    nitroprusside NO donor);
    Induction: By cytokines and mitogens

         Genatlas biochemistry entry for PTGS2:
    prostaglandin G/H synthase 2,mitogen and cytokine inducible form (lipocalin family,Kernel group),monomer,potent
    mediator of inflammation,playing a minor role in colorectal carcinogenesis,overexpressed in squamous cell
    carcinoma of the head and neck,putatively involved in the tumor tissue response to necrosis

         Enzyme Numbers (IUBMB): EC 2 EC 1.14.992

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity NAS14511332
    GO:0004666prostaglandin-endoperoxide synthase activity IDA1380156
    GO:0005515protein binding ----
    GO:0008289lipid binding IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    Find genes that share ontologies with PTGS2           About GenesLikeMe

         Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Ptgs2) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with PTGS2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTGS2: Ptgs2tm1Unc Ptgs2tm2(Ptgs1)Fun Ptgs2tm3Fun Ptgs2tm1Jed

       genOway: Develop your customized and physiologically relevant rodent model for PTGS2

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for PTGS2

    miRTarBase miRNAs that target PTGS2:
    hsa-mir-181a-5p (MIRT025094), hsa-mir-16-5p (MIRT001426), hsa-mir-137 (MIRT006329), hsa-mir-124-3p (MIRT022542), hsa-let-7b-5p (MIRT001603), hsa-mir-101-3p (MIRT004297), hsa-mir-26b-5p (MIRT004659), hsa-mir-132-3p (MIRT021768), hsa-mir-128-3p (MIRT021956), hsa-mir-335-5p (MIRT017755)

    Block miRNA regulation of human, mouse, rat PTGS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTGS2 (see all 23):
    hsa-miR-4291 hsa-miR-576-3p hsa-miR-624* hsa-miR-1297 hsa-miR-144 hsa-miR-629* hsa-miR-558 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidPTGS2 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for PTGS2
    Predesigned siRNA for gene silencing in human, mouse, rat PTGS2

    OriGene clones in human, mouse for PTGS2 (see all 8)
    OriGene ORF clones in mouse, rat for PTGS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGS2 (NM_000963)
    Sino Biological Human cDNA Clone for PTGS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS2

    Cell Line
    GenScript Custom overexpressing Cell Line Services for PTGS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTGS2 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-10359) for PTGS2 

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    PGH2_HUMAN, P35354: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    endoplasmic reticulum5
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043005neuron projection IDA12355421
    GO:0043234protein complex IEA--

    Find genes that share ontologies with PTGS2           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for PTGS2 About   (see all 47)  
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.00
    Arachidonic acid metabolism0.40
    C20 prostanoid biosynthesis0.00
    HETE and HPETE biosynthesis and metabolism0.33
    Synthesis of 15-eicosatetraenoic acid derivatives0.00
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Eicosanoid Synthesis
    Eicosanoid Synthesis
    aspirin triggered resolvin E biosynthesis0.00
    4PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    all-trans-Retinoic Acid Signaling in Brain0.71
    MIF Mediated Glucocorticoid Regulation0.94
    Endothelin-1 Signaling Pathway0.46
    5Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcium signaling in the CD4+ TCR pathway0.38
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38

    Find genes that share SuperPaths with PTGS2           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTGS2 (see all 13)
        MIF Regulation of Innate Immune Cells
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    HGF Pathway
    Endothelin-1 Signaling Pathway
    Colorectal Cancer Metastasis

    3 Cell Signaling Technology (CST) Pathways for PTGS2
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PTGS2 (see all 10)
        HETE and HPETE biosynthesis and metabolism
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Development VEGF signaling via VEGFR2 - generic cascades
    Transcription PPAR Pathway

    Selected BioSystems Pathways for PTGS2 (see all 13)
        Eicosanoid Synthesis
    Selenium Pathway
    Prostaglandin Synthesis and Regulation
    C20 prostanoid biosynthesis
    aspirin triggered resolvin E biosynthesis

    2 Reactome Pathways for PTGS2
        Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

    3 PharmGKB Pathways for PTGS2
        Acetaminophen Pathway, Pharmacokinetics
    Celecoxib Pathway, Pharmacodynamics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PTGS2) (see all 14):
        Arachidonic acid metabolism
    Metabolic pathways
    NF-kappa B signaling pathway
    VEGF signaling pathway
    TNF signaling pathway

    UniProtKB/Swiss-Prot: PGH2_HUMAN, P35354
    Pathway: Lipid metabolism; prostaglandin biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTGS2 (see all 25): 

              Lung Cancer in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat


        GeneGlobe Interaction Network for PTGS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTGS2 (P353543 ENSP000003564384) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958703, ENSP000003792824I2D: score=1 STRING: ENSP00000379282
    ENSG00000206403O958703I2D: score=1 
    ENSG00000224552O958703I2D: score=1 
    ENSG00000230475O958703I2D: score=1 
    ENSG00000231488O958703I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 66):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process NAS--
    GO:0001525angiogenesis IEA--
    GO:0006693prostaglandin metabolic process TAS9630216
    GO:0006928cellular component movement TAS9630216
    GO:0006954inflammatory response IEA--

    Find genes that share ontologies with PTGS2           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PTGS2
      Browse compounds at ApexBio 

    Compounds for PTGS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CelecoxibSelective cyclooxygenase-2 (COX-2) inhibitor[169590-42-5]
    ResveratrolCyclooxygenase inhibitor[501-36-0]
    NS 398Cyclooxygenase-2 (COX-2) inhibitor[123653-11-2]
    SC 58125Selective cyclooxygenase-2 (COX-2) inhibitor[162054-19-5]
    IndomethacinCyclooxygenase inhibitor (COX-1 > COX-2)[53-86-1]

    Selected HMDB Compounds for PTGS2 (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    11R-HEPE11(R)-hydroxyeicosa-5Z,8Z,12E,14Z,17Z-pentaenoate (see all 2)----
    Acetaminophen4'-Hydroxyacetanilide (see all 629)103-90-2--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Aspirin2-(Acetyloxy)benzoic acid (see all 59)50-78-2--
    CelecoxibCelebrex (see all 3)169590-42-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Ibuprofenalpha-(4-Isobutylphenyl)propionate (see all 9)15687-27-1--
    IronArmco iron (see all 19)7439-89-6--
    Naproxen(+)-(S)-Naproxen (see all 49)22204-53-1--
    OxygenOxygen (see all 5)7782-44-7--

    Selected DrugBank Compounds for PTGS2 (see all 72)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RofecoxibMK 966 (see all 2)162011-90-7targetinhibitor10566562 20724158 10555907 10693877 11752352 18922570 20166930 11398914 10643177 10580458
    FlurbiprofenFLP (see all 5)5104-49-4targetinhibitor19066416 17562170 10091674 10773011 10977131 11006278 11405284
    IbuprofenIbuprophen (see all 3)15687-27-1targetinhibitor15494133 15556152 14510637 11752352 12852704 15481334
    enzymeinhibitor15494133 15556152 14510637 11752352 12852704 15481334 22668799
    Valdecoxib-- 181695-72-7targetinhibitor11060833 12564662 12167567 10715145 11752352 12644588 15494548
    Acetylsalicylic acid2-Acetoxybenzenecarboxylic acid (see all 24)50-78-2targetinhibitor17033106 17301265 17258197 11752352 17037745 17181859
    Antrafenine-- 55300-30-6targetinhibitor17604186 17612049 17607546 11752352 17532719 17521299
    Carprofen2-(6-Chloro-9H-carbazol-2-yl)propanoic acid (see all 6)53716-49-7targetinhibitor15198222 11703020 10895904 17181139 15939622 11752352
    Celecoxib-- 169590-42-5targetinhibitor12055598 12093311 12104042 11752352 12086402 12086292
    Diflunisal-- 22494-42-4targetinhibitor8737748 11673972 10825891 11752352 11315375 12852483
    Etodolac-- 41340-25-4targetinhibitor15198222 11009046 11752352 12824918 10594327 11275997

    7 IUPHAR Ligands for PTGS2 (COX-2 )    About this table
    LigandTypeActionAffinityPubmed IDs

    Selected Novoseek inferred chemical compound relationships for PTGS2 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    celecoxib 97 1888 18230053 (7), 18766003 (7), 15014359 (6), 16230415 (6) (see all 99)
    rofecoxib 96 933 20110006 (10), 10411562 (6), 17620346 (5), 17636557 (4) (see all 99)
    pge2 94.8 3923 18727513 (9), 19452719 (9), 12493746 (8), 16585602 (7) (see all 99)
    prostaglandin 92.7 1317 10735591 (5), 10692251 (4), 9016346 (4), 8063757 (3) (see all 99)
    ns 398 92.2 312 14630280 (5), 15703831 (4), 15382039 (4), 19956533 (4) (see all 99)
    valdecoxib 91.6 196 15494548 (6), 17605893 (3), 18171312 (3), 17429597 (3) (see all 99)
    etoricoxib 89.3 163 11160644 (5), 12817520 (4), 15827069 (3), 19392653 (3) (see all 99)
    arachidonic acid 88.4 747 9373167 (6), 9461572 (5), 9973312 (4), 9031736 (4) (see all 99)
    nimesulide 88.3 372 18333314 (5), 18288985 (5), 19152549 (4), 14977856 (4) (see all 99)
    meloxicam 87.8 275 16245223 (4), 12911075 (3), 19078323 (3), 10812057 (3) (see all 99)

    3 PharmGKB related drug/compound annotations for PTGS2 gene    About this table
    Drug/compound PharmGKB Annotation

    Find genes that share compounds with PTGS2           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for PTGS2 gene: 

    Unigene Cluster for PTGS2:

    Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    Hs.196384  [show with all ESTs]
    Unigene Representative Sequence: NM_000963
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367468(uc001gsb.3 uc009wyo.3) ENST00000490885 ENST00000559627
    ENST00000466691 ENST00000559800
    Block miRNA regulation of human, mouse, rat PTGS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTGS2 (see all 23):
    hsa-miR-4291 hsa-miR-576-3p hsa-miR-624* hsa-miR-1297 hsa-miR-144 hsa-miR-629* hsa-miR-558 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidPTGS2 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for PTGS2
    Predesigned siRNA for gene silencing in human, mouse, rat PTGS2
    OriGene clones in human, mouse for PTGS2 (see all 8)
    OriGene ORF clones in mouse, rat for PTGS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGS2 (NM_000963)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS2
    OriGene qPCR primer pairs and template standards for PTGS2
    OriGene qSTAR qPCR primer pairs in human, mouse for PTGS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTGS2
      QuantiTect SYBR Green Assays in human, mouse, rat PTGS2
      QuantiFast Probe-based Assays in human, mouse, rat PTGS2
    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-10359) for PTGS2 

    Additional mRNA sequence: 

    AJ634912.1 AK292167.1 AY151286.1 AY462100.1 BC013734.1 HM473188.1 L15326.1 M90100.1 

    3 DOTS entries:

    DT.413375  DT.91935010  DT.121406567 

    Selected AceView cDNA sequences (see all 101):

    AA296431 AY462100 AA644211 CB960307 CB143773 D58162 BM978796 BG236304 
    BQ100978 BQ722004 CD365731 BQ100700 CK823042 CK823043 AL710813 BP335244 
    AJ634912 BG152882 BC013734 BP337788 T29235 BV199193 BM128780 AL710848 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PTGS2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                                                                                -                     
    SP2:                                                  -                             -                     
    SP3:                                                                                -                     

    ECgene alternative splicing isoforms for PTGS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    PTGS2 Expression
    About this image

    PTGS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Mural Granulosa Cells Antral Follicle
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
             Cardiac Fibroblasts Myocardium
             Detroit 551
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    PTGS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTGS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.196384
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTGS2 (see all 25): 
              Lung Cancer in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    OriGene qPCR primer pairs and template standards for PTGS2
    OriGene qSTAR qPCR primer pairs in human, mouse for PTGS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTGS2
    QuantiTect SYBR Green Assays in human, mouse, rat PTGS2
    QuantiFast Probe-based Assays in human, mouse, rat PTGS2
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PTGS2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Ptgs21 , 5 prostaglandin-endoperoxide synthase 21, 5 84.92(n)1
      1 (63.84 cM)5
    192251  NM_011198.31  NP_035328.21 
    (Gallus gallus)
    Aves PTGS21 prostaglandin-endoperoxide synthase 2 (prostaglandin more 78.23(n)
      396451  NM_001167719.1  NP_001161191.1 
    (Anolis carolinensis)
    Reptilia PTGS26
    prostaglandin-endoperoxide synthase 2 (prostagland...
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.333292 Xenopus laevis transcribed sequence with moderate similarity more 75.65(n)    CA988090.1 
    (Danio rerio)
    Actinopterygii ptgs22 prostaglandin-endoperoxide synthase 2 75.55(n)   246227  AY028585.1 

    ENSEMBL Gene Tree for PTGS2 (if available)
    TreeFam Gene Tree for PTGS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for PTGS2 gene
    2 SIMAP similar genes for PTGS2 using alignment to 3 protein entries:     PGH2_HUMAN (see all proteins):
    COX-2    PTGS1

    Find genes that share paralogs with PTGS2           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for PTGS2 (see all 516)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 1 posSequence#AA
    C--186646588(+) TGTGT-/GTATAAT 1 -- int10--------
    C--186650999(-) AGACTT/-CTACA 1 -- us2k11Minor allele frequency- -:0.01NS 172
    C,F,H--193187485(-) cctctA/Gtcctt 1 -- ds500122Minor allele frequency- G:0.02NS EA NA 2134
    --193187526(+) ATGATC/TTGCCC 1 -- ds50010--------
    --193187545(+) ATAATA/TTCCTC 1 -- ds50010--------
    C,F--193187574(-) GGGGGC/GACAAA 1 -- ds50011Minor allele frequency- G:0.01NS 180
    C,F,A,H--193187577(-) GAAGGG/AGGCAC 1 -- ds500119Minor allele frequency- A:0.29NS NA WA CSA EA 1302
    --193187598(+) TCTTAC/TTCTTT 1 -- ds50010--------
    --193187633(+) TTCTTC/GTAGAC 1 -- ds50010--------
    --193187652(+) GAAAAC/TAAGCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PTGS2 (186640923 - 186649559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PTGS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv413n71CNV Loss21882294
    nsv470750CNV Loss18288195
    dgv412n71CNV Loss21882294
    dgv414n71CNV Loss21882294
    nsv872590CNV Gain21882294

    Human Gene Mutation Database (HGMD): PTGS2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 600262    OMIM disorders: --

    Selected diseases for PTGS2 (see all 35):    
    About MalaCards
    bile duct cysts    protoplasmic astrocytoma    acute generalized exanthematous pustulosis    familial adenomatous polyposis
    malignant mesenchymal tumor    uterine carcinosarcoma    barrett's esophagus    colonic disease
    adiponectin deficiency    small bowel adenocarcinoma    bowenoid papulosis    spondylolisthesis
    choledochal cyst    morphine dependence    bursitis    juvenile polyposis syndrome
    pharyngitis    wrinkles    urinary tract obstruction    adenocarcinoma

    Selected inferred disease relationships from the University of Copenhagen DISEASES database for PTGS2 (see all 22):
    Colorectal cancer     Arthritis     Carcinoma     Vascular disease
    Familial adenomatous polyposis     Gastrointestinal system disease     Adenoma     Lung cancer
    Pain agnosia     Breast cancer     Brain disease     Esophageal cancer
    Myocardial infarction     Prostate cancer     Skin cancer     Alzheimer's disease
    Urinary bladder cancer     Kidney disease     Endometriosis     Pancreatic cancer

    Find genes that share disorders with PTGS2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTGS2 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 82.3 1159 16580899 (5), 11437671 (4), 10414396 (4), 12669881 (4) (see all 99)
    colon cancer 78.8 585 19437564 (7), 12432918 (6), 20046424 (5), 18320325 (5) (see all 99)
    osteoarthritis 78.6 261 15974939 (4), 10560596 (3), 19602530 (3), 19807303 (3) (see all 99)
    tumors 76.5 3567 15200266 (8), 20192574 (8), 19329856 (7), 16139560 (7) (see all 99)
    colorectal cancer 76.2 748 19671325 (9), 16324362 (7), 16551850 (7), 19132985 (6) (see all 99)
    gastrointestinal complications 75.5 50 15475342 (3), 19947799 (2), 15190384 (2), 17552414 (2) (see all 33)
    cancer 75 1766 16124396 (6), 12692419 (6), 17428102 (5), 16007171 (5) (see all 99)
    familial adenomatous polyposis 72.3 128 14581346 (3), 10874062 (3), 16622748 (2), 11495083 (2) (see all 86)
    gastrointestinal ulcers 71.7 19 17611980 (1), 12208114 (1), 18356636 (1), 11961974 (1) (see all 14)
    rheumatoid arthritis 69.3 196 15974939 (3), 18261308 (3), 11087881 (2), 15775145 (2) (see all 99)

    Genetic Association Database (GAD): PTGS2
    Human Genome Epidemiology (HuGE) Navigator: PTGS2 (284 documents)

    Export disorders for PTGS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGS2 gene, integrated from 10 sources (see all 6739) (see top 10):
    (articles sorted by number of sources associating them with PTGS2)

    1. Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. (PubMed id 17181859)1, 4, 7, 9 Shen J....Santella R.M. (Breast Cancer Res. 2006)
    2. Human cyclooxygenase-2 cDNA. (PubMed id 1380156)1, 2, 3 Hla T. and Neilson K. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. (PubMed id 19437564)1, 4, 9 Thompson C.L....Li L. (World J. Gastroenterol. 2009)
    4. COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. (PubMed id 17609663)1, 4, 9 Cheng I....Witte J.S. (Br. J. Cancer 2007)
    5. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. (PubMed id 19327107)1, 4, 9 Xie X....Liu F. (Clin. Chem. Lab. Med. 2009)
    6. Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. (PubMed id 19755647)1, 4, 9 Barry E.L....Baron J.A. (amp 2009)
    7. The COX-2 promoter polymorphism -765 G&gt;C is associated with early-onset, conventional and stump gastric cancers. (PubMed id 18311113)1, 4, 9 Sitarz R....Milne A.N. (Mod. Pathol. 2008)
    8. COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population. (PubMed id 18214026)1, 4, 9 Hou L....Chow W.H. (Anticancer Res. 2007)
    9. Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. (PubMed id 17479405)1, 4, 9 Gao J....Shen H.B. (J. Toxicol. Environ. Health Part A 2007)
    10. The cyclooxygenase 2 genetic variant -765G&gt;C does not modulate the effects of celecoxib on prostaglandin E2 production. (PubMed id 17178263)1, 4, 9 Skarke C....LAPtsch J. (Clin. Pharmacol. Ther. 2006)
    11. Characterization of the human gene (PTGS2) encoding prostaglandin- endoperoxide synthase 2. (PubMed id 8181472)1, 2, 9 Kosaka T.... Tanabe T. (Eur. J. Biochem. 1994)
    12. PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19965896)1, 4, 9 Dossus L....Cox D.G. (Carcinogenesis 2010)
    13. Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans. (PubMed id 19031967)1, 4, 9 Ashktorab H....Ali I.U. (Anticancer Res. 2008)
    14. Relationship between cyclooxygenase 8473T&gt;C polymorphism and the risk of lung cancer: a case-control study. (PubMed id 16542464)1, 4, 9 Park J.M....Park J.Y. (BMC Cancer 2006)
    15. Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. (PubMed id 15173859)1, 4, 9 Cox D.G....Moreno V. (Br. J. Cancer 2004)
    16. -765G&gt;C and 8473T&gt;C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies. (PubMed id 19669667)1, 4, 9 Zhu W....Liu P. (Mol. Biol. Rep. 2010)
    17. Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: implication for pharmacogenomics. (PubMed id 20110601)1, 4, 9 ListA- F....Candore G. (J. Alzheimers Dis. 2010)
    18. Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. (PubMed id 19422084)1, 4, 9 Zhao D....Lin D. (Gastroenterology 2009)
    19. COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. (PubMed id 18974063)1, 4, 9 Fernandez P....Heyns C.F. (Carcinogenesis 2008)
    20. Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. (PubMed id 17640058)1, 4, 9 Hubner R.A....Houlston R.S. (Int. J. Cancer 2007)
    21. COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States). (PubMed id 16489533)1, 4, 9 Sansbury L.B....Sandler R.S. (amp 2006)
    22. A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. (PubMed id 15777967)1, 4, 9 Hu Z....Shen H. (Lung Cancer 2005)
    23. COX-2 gene promoter haplotypes and prostate cancer risk. (PubMed id 14754878)1, 4, 9 Panguluri R.C....Kittles R.A. (Carcinogenesis 2004)
    24. Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer. (PubMed id 20332326)1, 4, 9 Bi N....Wang L. (Clin. Cancer Res. 2010)
    25. No association between the PPARG gene and schizophrenia in a British population. (PubMed id 19560328)1, 4, 9 Mathur A....Wei J. (Prostaglandins Leukot. Essent. Fatty Acids 2009)
    26. Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. (PubMed id 19463183)1, 4, 9 Hu H.M....Wu D.C. (BMC Gastroenterol 2009)
    27. Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy. (PubMed id 18825488)1, 4, 9 Achyut B.R....Mittal B. (Mol. Cell. Biochem. 2009)
    28. COX-2 polymorphisms in patients with familial adenomatous polyposis. (PubMed id 19544971)1, 4, 9 Peters W.H....Nagengast F.M. (Oncol. Res. 2009)
    29. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PubMed id 19276290)1, 4, 9 Abraham J.E....Pharoah P.D. (Clin. Cancer Res. 2009)
    30. COX-2 polymorphisms -765G--&gt;C and -1195A--&gt;G and colorectal cancer risk. (PubMed id 19777615)1, 4, 9 Hoff J.H....Peters W.H. (World J. Gastroenterol. 2009)
    31. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. (PubMed id 19318492)1, 4, 9 Fradet V....Witte J.S. (Clin. Cancer Res. 2009)
    32. Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: the Self Defense Forces Health Study. (PubMed id 18167131)1, 4, 9 Ueda N....Kono S. (Cancer Sci. 2008)
    33. Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. (PubMed id 18349295)1, 4, 9 Ferguson H.R....Hardie L.J. (amp 2008)
    34. Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese. (PubMed id 17234302)1, 4, 9 Ma S.L....Lam L.C. (Neurobiol. Aging 2008)
    35. Cyclooxygenase-2 polymorphisms and risk of rheumatoid arthritis in Koreans. (PubMed id 18381795)1, 4, 9 Yun H.R....Bae S.C. (J. Rheumatol. 2008)
    36. Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. (PubMed id 17999989)1, 4, 9 Danforth K.N....Hsing A.W. (Carcinogenesis 2008)
    37. [Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer]. (PubMed id 19062735)1, 4, 9 Xu D.K....Lin D.X. (Zhonghua Yi Xue Za Zhi 2008)
    38. Cyclooxygenase 2 polymorphism and colorectal cancer: -765G&gt;C variant modifies risk associated with smoking and body mass index. (PubMed id 18350611)1, 4, 9 Xing L.L....Zhang X. (World J. Gastroenterol. 2008)
    39. MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer. (PubMed id 17851225)1, 4, 9 Pan J.H....Yu Q.Z. ( international review of thoracic diseases 2008)
    40. Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population. (PubMed id 17404026)1, 4, 9 Lee T.S....Song Y.S. (Ann. N. Y. Acad. Sci. 2007)
    41. Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism. (PubMed id 17066444)1, 4, 9 Hedelin M....BAolter K.A. (Int. J. Cancer 2007)
    42. Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis. (PubMed id 17322116)1, 7, 9 Weinheimer E.M....Trappe T.A. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007)
    43. Genetic variation in the COX-2 gene and the association with prostate cancer risk. (PubMed id 16506214)1, 4, 9 Shahedi K....Xu J. (Int. J. Cancer 2006)
    44. The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease. (PubMed id 16309832)1, 4, 9 Abdullah L....Mullan M. (Neurosci. Lett. 2006)
    45. Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs. (PubMed id 16678543)1, 4, 9 Lee Y.S....Dionne R.A. (Clin. Pharmacol. Ther. 2006)
    46. Cyclooxygenase-2 genotype and rheumatoid arthritis. (PubMed id 16821264)1, 4, 9 Lee K.H....Bae S.C. (J. Rheumatol. 2006)
    47. Polymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancer. (PubMed id 15596291)1, 4, 9 Kang S....Lee H.P. (Cancer Lett. 2005)
    48. Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption. (PubMed id 15550453)1, 4, 9 Siezen C.L....Kampman E. (Carcinogenesis 2005)
    49. Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease. (PubMed id 16273614)1, 4, 9 Cox D.G....Canzian F. (World J. Gastroenterol. 2005)
    50. Functional promoter polymorphism of cyclooxygenase-2 modulates the inflammatory response in stable coronary heart disease. (PubMed id 20332714)1, 4, 9 Sanak M....Szczeklik A. (Pol. Arch. Med. Wewn. 2010)
    51. Functional rs20417 SNP (-765G&gt;C) of cyclooxygenase-2 gene does not predict the risk of recurrence of ischemic events in coronary patients: results of a 7-year prospective study. (PubMed id 20299798)1, 4, 9 Montali A....Arca M. (Cardiology 2010)
    52. Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. (PubMed id 19748095)1, 4, 9 Vogel U....Overvad K. (Atherosclerosis 2010)
    53. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4, 9 Lemaitre R.N....Psaty B.M. (Atherosclerosis 2009)
    54. Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population. (PubMed id 18819034)1, 4, 9 A9stergaard M....Andersen V. (Scand. J. Gastroenterol. 2009)
    55. A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis. (PubMed id 18930197)1, 4, 9 Juo S.H....Tsai E.M. (Fertil. Steril. 2009)
    56. Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions. (PubMed id 19197984)1, 4, 9 Pu X....Wu X. (Cancer 2009)
    57. Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma. (PubMed id 19205707)1, 4, 9 Gong Z....Hebert J.R. (Int J Colorectal Dis 2009)
    58. Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma. (PubMed id 19630103)1, 4, 9 Kristinsson J.O....Peters W.H. (World J. Gastroenterol. 2009)
    59. Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. (PubMed id 19889076)1, 4, 9 Hung K.H....Sheu B.S. (Helicobacter 2009)
    60. COX-2 polymorphisms and the risk for head and neck cancer in white patients. (PubMed id 19280666)1, 4, 9 Peters W.H....Manni J.J. (amp 2009)
    61. Effect of COX2 -765G&gt;C and c.3618A&gt;G polymorphisms on the risk and survival of sporadic colorectal cancer. (PubMed id 19468846)1, 4, 9 Iglesias D....FernA!ndez-Peralta A.M. (amp 2009)
    62. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. (PubMed id 20016751)1, 4, 9 Grimminger P.P....Brabender J. (J Oncol 2009)
    63. Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. (PubMed id 18768181)1, 4, 9 Rudock M.E....Bowden D.W. (Atherosclerosis 2009)
    64. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PubMed id 18038187)1, 4, 9 Hoeft B....Nieters A. (amp 2008)
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    66. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. (PubMed id 18471798)1, 4, 9 Valdes A.M....Spector T.D. (Am. J. Hum. Genet. 2008)
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    69. CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. (PubMed id 17924829)1, 4, 9 Kim S.H....Park H.S. (Pharmacogenomics 2007)
    70. Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. (PubMed id 17151091)1, 4, 9 Tan W....Lin D. (Carcinogenesis 2007)
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    73. Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. (PubMed id 17175104)1, 7, 9 Lee Y.S....Dionne R.A. (Pain 2007)
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    77. Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta. (PubMed id 16344721)1, 4, 9 Siezen C.L....Kampman E. (Pharmacogenet. Genomics 2006)
    78. Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. (PubMed id 16879213)1, 4, 9 Hegener H.H....Zee R.Y. (J. Thromb. Haemost. 2006)
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    82. Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -&gt; C COX-2 polymorphism. (PubMed id 15930344)1, 4, 9 Brosens L.A....Goggins M. (Clin. Cancer Res. 2005)
    83. Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (PubMed id 14749922)1, 4, 9 Choi J.H....Shin H.D. (Hum. Genet. 2004)
    84. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. (PubMed id 15138244)1, 4, 9 Cipollone F....Mezzetti A. (JAMA 2004)
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    89. Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (Mol. Carcinog. 2011)
    90. Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for urinary bladder cancer in North India. (PubMed id 20627335)1, 4 Gangwar R....Mittal R.D. (Surgery 2011)
    91. Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan. (PubMed id 21273602)1, 4 Wu H.C....Bau D.T. (Anticancer Res. 2011)
    92. Study on the association of COX-2 genetic polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu province in China. (PubMed id 20364406)1, 4 Ke-Xiang Z....Tao L. (Mol. Biol. Rep. 2011)
    93. Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. (PubMed id 20473875)1, 4 Zabaleta J....Ochoa A.C. (Int. J. Cancer 2011)
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    95. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    96. A pilot study on prostate cancer risk and pro-inflammatory genotypes: pathophysiology and therapeutic implications. (PubMed id 20388081)1, 4 Balistreri C.R....Candore G. (Curr. Pharm. Des. 2010)
    97. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. (PubMed id 20448286)1, 4 Potter C....Isaacs J.D. (Ann. Rheum. Dis. 2010)
    98. Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis. (PubMed id 20308035)1, 4 Van Hee V.C....Kaufman J.D. (Environ. Health Perspect. 2010)
    99. Polymorphisms in regulatory regions of cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study. (PubMed id 21059239)1, 4 Piranda D.N....Vianna-Jorge R. (BMC Cancer 2010)
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    101. Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. (PubMed id 20431935)1, 4 Zhang J....Kadlubar F.F. (amp 2010)
    102. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    103. Potentially functional COX-2-1195G&gt;A polymorphism increases the risk of digestive system cancers: a meta-analysis. (PubMed id 20594217)1, 4 Dong J....Shen H. (J. Gastroenterol. Hepatol. 2010)
    104. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    105. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    106. Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. (PubMed id 20944149)1, 4 Wang C.H....Bau D.T. (Anticancer Res. 2010)
    107. The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis. (PubMed id 20808059)1, 4 Cao H....Li S.L. (Tohoku J. Exp. Med. 2010)
    108. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    109. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1, 4 Hildebrandt M.A....Wu X. (PLoS ONE 2010)
    110. Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk. (PubMed id 20559705)1, 4 Lurie G....Goodman M.T. (amp 2010)
    111. Cyclooxygenase-2 gene polymorphisms and risk of cervical cancer in a North Indian population. (PubMed id 20686383)1, 4 Pandey S....Mittal B. (Int. J. Gynecol. Cancer 2010)
    112. Association of -765G&gt;C polymorphism of the COX-2 gene with recurrent embryo implantation failure in Southern Chilean women. (PubMed id 20599859)1, 4 Salazar L.A....GuzmA!n N. ( international journal of clinical chemistry 2010)
    113. Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis. (PubMed id 20033767)1, 4 Yu K.D....Shao Z.M. (Breast Cancer Res. Treat. 2010)
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    115. Cox-2 and IL-10 polymorphisms and association with squamous cell carcinoma of the head and neck in a Korean sample. (PubMed id 20592893)1, 4 Jeong S.W....Shin H.D. (J. Korean Med. Sci. 2010)
    116. Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients. (PubMed id 20720307)1, 4 Czerska K....Bal J. (J. Appl. Genet. 2010)
    117. Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. (PubMed id 20034614)1, 4 Su K.P....Pariante C.M. (Biol. Psychiatry 2010)
    118. The effect of genetic polymorphisms of cyclooxygenase 2 on acute pancreatitis in Turkey. (PubMed id 19820421)1, 4 Ozhan G....Alpertunga B. (Pancreas 2010)
    119. Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer. (PubMed id 20204402)1, 4 Knechtel G....Langsenlehner U. (J. Cancer Res. Clin. Oncol. 2010)
    120. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    121. TNF superfamily gene polymorphism as prognostic factor in early breast cancer. (PubMed id 19890662)1, 4 Jung J.H....Park H.Y. (J. Cancer Res. Clin. Oncol. 2010)
    122. COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention. (PubMed id 20075740)1, 4 Pereira C....Dinis-Ribeiro M. (amp 2010)
    123. Influence of cyclooxygenase-2 (COX-2) gene promoter polymorphism at position -765 on skin cancer after renal transplantation. (PubMed id 20445548)1, 4 Aubin F....Ducloux D. (J. Invest. Dermatol. 2010)
    124. A haplotype of cyclooxygenase-2 gene is associated with idiopathic pulmonary fibrosis. (PubMed id 21319594)1, 4 Xaubet A....Picado C. (Sarcoidosis Vasc Diffuse Lung Dis 2010)
    125. Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415). (PubMed id 20631636)1, 4 Gold P.J....Blanke C.D. (J Thorac Oncol 2010)
    126. Association study of interferon-I^, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease. (PubMed id 20808133)1, 4 FehAcr A....Janka Z. (Am J Geriatr Psychiatry 2010)
    127. Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk. (PubMed id 20688905)1, 4 Salinas C.A....Stanford J.L. (Am. J. Epidemiol. 2010)
    128. COX-2 is associated with periodontitis in Europeans. (PubMed id 20177132)1, 4 Schaefer A.S....Schreiber S. (J. Dent. Res. 2010)
    129. Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients. (PubMed id 20530427)1, 4 Liu C.J....Bau D.T. (Anticancer Res. 2010)
    130. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    131. Toll-like receptor signaling pathway variants and prostate cancer mortality. (PubMed id 19505919)1, 4 Stark J.R....Kraft P. (amp 2009)
    132. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    133. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    134. The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT. (PubMed id 18997828)1, 4 Vangsted A.J....Vogel U. (Bone Marrow Transplant. 2009)
    135. Cyclo-oxygenase-2 -765G &gt; C promoter variants are associated with lower carotid plaque echogenicity in Japanese. (PubMed id 19033684)1, 4 Furukado S....Kitagawa K. (Cerebrovasc. Dis. 2009)
    136. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    137. Polymorphisms cyclooxygenase-2 -765G&gt;C and interleukin-6 -174G&gt;C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts. (PubMed id 19056642)1, 4 Corella D....Estruch R. (J. Nutr. 2009)
    138. Association of COX2 functional polymorphisms and the risk of vitiligo in Chinese populations. (PubMed id 19004621)1, 4 Li M....Gao T. (J. Dermatol. Sci. 2009)
    139. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. (PubMed id 19930591)1, 4 Andersen V....Vogel U. (BMC Cancer 2009)
    140. Role of inflammation gene polymorphisms on pain severity in lung cancer patients. (PubMed id 19773451)1, 4 Reyes-Gibby C.C....Shete S. (amp 2009)
    141. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. (PubMed id 19661089)1, 4 Hussain S.K....Zhang Z.F. (amp 2009)
    142. G-765C COX-2 gene promoter polymorphism and risk of atherosclerosis after kidney transplantation. (PubMed id 19920789)1, 4 Courivaud C....Thervet E. (Transplantation 2009)
    143. Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T&gt;C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. (PubMed id 19219602)1, 4 Kim J.G....Jun S.H. (Cancer Chemother. Pharmacol. 2009)
    144. Cyclooxygenase-2 polymorphisms confer susceptibility to sarcoidosis but are not related to prognosis. (PubMed id 19042116)1, 4 Lopez-Campos J.L....Montes-Worboys A. (Respir Med 2009)
    145. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
    146. Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available? (PubMed id 19060633)1, 4 Pereira C....Dinis-Ribeiro M.J. (amp 2009)
    147. The influence of COX-2 single nucleotide polymorphisms on abdominal aortic aneurysm development and the associated inflammation. (PubMed id 19625268)1, 4 Badger S.A....Hughes A.E. (Angiology 2009)
    148. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    149. Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: a meta-analysis. (PubMed id 19631939)1, 4 Li W....Hui R. (Atherosclerosis 2009)
    150. Influence of a type 2 diabetes associated prostaglandin E synthase 2 polymorphism on blood prostaglandin E2 levels. (PubMed id 19268562)1, 4 Boomgaarden I....DAPring F. (Prostaglandins Leukot. Essent. Fatty Acids 2009)
    151. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
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    154. Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. (PubMed id 19706164)1, 4 Kang K.B....Wong M.C. (Mol. Cancer 2009)
    155. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    156. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    157. Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population. (PubMed id 19455278)1, 4 Srivastava K....Mittal B. (J. Gastroenterol. 2009)
    158. Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma. (PubMed id 19223558)1, 4 Chang E.T....Mueller N.E. (amp 2009)
    159. PTGS2-899G&gt;C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis. (PubMed id 19488068)1, 4 Murad A....Martin R.M. (Prostate Cancer Prostatic Dis. 2009)
    160. Cyclooxygenase-2 Gly587Arg variant is associated with differential enzymatic activity and risk of esophageal squamous-cell carcinoma. (PubMed id 19347867)1, 4 Zhao D....Lin D. (Mol. Carcinog. 2009)
    161. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    162. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    163. PTGS2 (COX-2) -765 G &gt; C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma. (PubMed id 17968676)1, 4 Ben Nasr H....Chouchane L. (Mol. Biol. Rep. 2009)
    164. Relation of genetic polymorphisms in the cytochrome P450 gene with clopidogrel resistance after drug-eluting stent implantation in Koreans. (PubMed id 19576320)1, 4 Lee J.M....Jang Y. (Am. J. Cardiol. 2009)
    165. The genomic basis of cerebral palsy: a HuGE systematic literature review. (PubMed id 19238444)1, 4 O'Callaghan M.E....Dekker G. (Hum. Genet. 2009)
    166. A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer. (PubMed id 19138835)1, 4 Li F....Li J. (Clin Oncol (R Coll Radiol) 2009)
    167. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    168. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (Genomics 2009)
    169. Influence of cyclooxygenase-2 (COX-2) gene promoter polymorphism -765 on graft loss after renal transplantation. (PubMed id 19788502)1, 4 Courivaud C....Ducloux D. (Am. J. Transplant. 2009)
    170. Common single nucleotide polymorphisms in cyclooxygenase-2 and risk of severe chronic periodontitis in a Chinese population. (PubMed id 19236532)1, 4 Xie C.J....Zhang J.C. (J. Clin. Periodontol. 2009)
    171. Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. (PubMed id 19047118)1, 4 Lurje G....Lenz H.J. (Clin. Cancer Res. 2008)
    172. Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease. (PubMed id 18989535)1, 4 Szczeklik W....Szczeklik A. (Thromb. Haemost. 2008)
    173. Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions. (PubMed id 18287876)1, 4 Canzian F....Kato I. (Eur. J. Cancer Prev. 2008)
    174. Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery. (PubMed id 18771989)1, 4 Skupski D.W....Witkin S.S. (Am. J. Obstet. Gynecol. 2008)
    175. COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men: the Helsinki sudden death study. (PubMed id 18385811)1, 4 Huuskonen K.H....Nikkari S.T. (Mediators Inflamm. 2008)
    176. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. (PubMed id 18992148)1, 4 KA1ry S....BAczieau S. (BMC Cancer 2008)
    177. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)
    178. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    179. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    180. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    181. Association between PTGS2 polymorphism and autism spectrum disorders in Korean trios. (PubMed id 18579107)1, 4 Yoo H.J....Kim S.A. (Neurosci. Res. 2008)
    182. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PubMed id 18691306)1, 4 Chan I.H....Lam C.W. (Allergy 2008)
    183. Polymorphism of -765G &gt; C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: a study from northern India. (PubMed id 18330937)1, 4 Saxena A....Husain N. (World J. Gastroenterol. 2008)
    184. Cyclooxygenase-2 gene polymorphisms in an Australian population: association of the -1195G &gt; A promoter polymorphism with mild asthma. (PubMed id 18489027)1, 4 Shi J....Thompson P.J. (Clin. Exp. Allergy 2008)
    185. Polymorphisms of COX-2 -765G&gt;C and p53 codon 72 and risks of oral squamous cell carcinoma in a Taiwan population. (PubMed id 18234542)1, 4 Lin Y.C....Chen C.H. (Oral Oncol. 2008)
    186. Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. (PubMed id 18164040)1, 4 Vogel U....nneland A. (Mutat. Res. 2008)
    187. Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype. (PubMed id 19075598)1, 4 Siemes C....Stricker B.H. (Curr Cancer Drug Targets 2008)
    188. Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 17495879)1, 4 Lee C.R....Zeldin D.C. (Clin. Pharmacol. Ther. 2008)
    189. Association of the 3050G&gt;C polymorphism in the cyclooxygenase 2 gene with systemic sarcoidosis. (PubMed id 18514098)1, 4 Lopez-Campos J.L....Montes-Worboys A. (Arch. Med. Res. 2008)
    190. Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. (PubMed id 18173398)1, 4 Ho Y.P....Tsai C.C. (J. Clin. Periodontol. 2008)
    191. Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. (PubMed id 18381966)1, 4 Yang H....Wu X. (Clin. Cancer Res. 2008)
    192. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    193. Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G&gt;a polymorphism reveal risk of oral cancer. (PubMed id 18922923)1, 4 Chiang S.L....Ko Y.C. (Cancer Res. 2008)
    194. COX2 and p53 risk-alleles coexist in COPD. (PubMed id 18692035)1, 4 Arif E....Pasha M.A. ( international journal of clinical chemistry 2008)
    195. Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. (PubMed id 17578436)1, 4 Lira M.G....Turco A. (Br. J. Dermatol. 2007)
    196. Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes. (PubMed id 17307204)1, 4 Vogel U....nneland A. (Mutat. Res. 2007)
    197. A multigenic approach to predict breast cancer risk. (PubMed id 17058024)1, 4 Gerger A....Krippl P. (Breast Cancer Res. Treat. 2007)
    198. Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant. (PubMed id 16905570)1, 4 Harding D.R....Montgomery H.E. (Arch. Dis. Child. Fetal Neonatal Ed. 2007)
    199. COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma. (PubMed id 17581270)1, 4 Moons L.M....Kusters J.G. (Am. J. Gastroenterol. 2007)
    200. Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. (PubMed id 17356794)1, 4 Campa D....Canzian F. (amp 2007)
    201. Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. (PubMed id 17573729)1, 4 Chan I.H....Lam C.W. (Allergy 2007)
    202. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    203. A fetal cyclooxygenase-2 gene polymorphism is associated with placental malperfusion. (PubMed id 17581413)1, 4 Polydorides A.D....Baergen R.N. (Int. J. Gynecol. Pathol. 2007)
    204. An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk. (PubMed id 18006935)1, 4 Schwartzbaum J.A....Feychting M. (amp 2007)
    205. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (PubMed id 17355643)1, 4 Huang H.Y....Helzlsouer K.J. (BMC Genet. 2007)
    206. COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G&gt;C with disease risk. (PubMed id 17373929)1, 4 Mazzola S....Pignatti P.F. (Int. J. Immunogenet. 2007)
    207. Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes. (PubMed id 16959787)1, 4 Vogel U....nneland A. (Carcinogenesis 2007)
    208. Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. (PubMed id 17560944)1, 7 Chae S.W....Choi H.J. (Biochem. Biophys. Res. Commun. 2007)
    209. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    210. Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population. (PubMed id 16762620)1, 4 Liu F....You W. (Gastroenterology 2006)
    211. The cyclooxygenase-2 (PTGS2) 8473T&gt;C polymorphism is associated with breast cancer risk. (PubMed id 16489098)1, 4 Langsenlehner U....Krippl P. (Clin. Cancer Res. 2006)
    212. Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. (PubMed id 16702043)1, 4 Kranzhofer R. and Ruef J. (Platelets 2006)
    213. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab. (PubMed id 16788380)1, 4 Zhang W....Lenz H.J. (Pharmacogenet. Genomics 2006)
    214. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PubMed id 17202846)1, 4 Park B.L....Shin H.D. (amp 2006)
    215. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. (PubMed id 16453284)1, 4 Valdes A.M....Spector T.D. (Arthritis Rheum. 2006)
    216. Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients. (PubMed id 16407418)1, 4 de las PeA+as R....Rosell R. (Ann. Oncol. 2006)
    217. -765G &gt; C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia. (PubMed id 17006983)1, 4 Pereira C....Dinis-Ribeiro M. (World J. Gastroenterol. 2006)
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    219. Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. (PubMed id 16361272)1, 4 Sakoda L.C....Hsing A.W. (Carcinogenesis 2006)
    220. Functional prostaglandin-endoperoxide synthase 2 polymorphism predicts poor outcome in sarcoidosis. (PubMed id 16840740)1, 4 Hill M.R....Laurent G.J. (Am. J. Respir. Crit. Care Med. 2006)
    221. Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans. (PubMed id 16871410)1, 4 Her M.Y....Bae S.C. (Rheumatol. Int. 2006)
    222. A genetic polymorphism in prostaglandin synthase 2 (8473, T--&gt;C) and the risk of lung cancer. (PubMed id 15882925)1, 4 SA...Raaschou-Nielsen O. (Cancer Lett. 2005)
    223. Polymorphisms associated with asthma are inversely related to glioblastoma multiforme. (PubMed id 16024651)1, 4 Schwartzbaum J....Feychting M. (Cancer Res. 2005)
    224. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. (PubMed id 16373578)1, 2 Kim S.F.... Snyder S.H. (Science 2005)
    225. Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. (PubMed id 16205694)1, 4 Ali I.U....Greenwald P. (Br. J. Cancer 2005)
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    227. Cyclooxygenase-1 haplotype modulates platelet response to aspirin. (PubMed id 16150050)1, 4 Maree A.O....Fitzgerald D.J. (J. Thromb. Haemost. 2005)
    228. A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. (PubMed id 16181776)1, 4 Wei J. and Hemmings G.P. (Prostaglandins Leukot. Essent. Fatty Acids 2005)
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    230. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    231. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)1, 4 Iwai N....Shioji K. (J. Hypertens. 2004)
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    233. A functional polymorphism in the promoter region of the cyclooxygenase-2 gene is not associated with asthma and atopy in an Australian population. (PubMed id 15544595)1, 4 Shi J....Kedda M.A. (Clin. Exp. Allergy 2004)
    234. Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians. (PubMed id 12920574)1, 4 Konheim Y.L. and Wolford J.K. (Hum. Genet. 2003)
    235. Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. (PubMed id 12433707)1, 4 Lin H.J....Smith W.L. (amp 2002)
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    242. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. (PubMed id 11959891)1, 9 Song X....Chen C.S. (J. Natl. Cancer Inst. 2002)
    243. Cyclooxygenase-2 (COX-2) negatively regulates expression of epidermal growth factor receptor and causes resistance to gefitinib in COX-2-overexpressing cancer cells. (PubMed id 19671676)1, 9 Kim Y.M....Pyo H. (Mol. Cancer Res. 2009)
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    245. Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. (PubMed id 11891209)1, 9 Niki T....Hirohashi S. (Am. J. Pathol. 2002)
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    249. Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. (PubMed id 18230181)1, 9 Kawasaki T....Ogino S. (BMC Cancer 2008)
    250. Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. (PubMed id 18671849)1, 9 Zhu Y.M....Woll P.J. (BMC Cancer 2008)
    251. Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. (PubMed id 15921850)1, 9 Cressey R....Leartprasertsuke N. (Cancer Lett. 2006)
    252. Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. (PubMed id 15608668)1, 9 Corcoran C.A....Sheikh M.S. (Oncogene 2005)
    253. Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. (PubMed id 15968728)1, 9 Zhi Y.H....Guo R.X. (World J. Gastroenterol. 2005)
    254. Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. (PubMed id 15156159)1, 9 Murata H....Hori M. ( a journal of technical methods and pathology 2004)
    255. Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. (PubMed id 12767510)1, 9 Yu H.G....Schmitz F. (Cancer Lett. 2003)
    256. Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma. (PubMed id 14532971)1, 9 Leung W.K....Sung J.J. (Int. J. Oncol. 2003)
    257. Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. (PubMed id 11078056)7, 9 Fosslien E. (Crit Rev Clin Lab Sci 2000)
    258. Expression and prognostic significance of Cox-2 and p-53 in Hodgkin lymphomas: a retrospective study. (PubMed id 20346139)1, 9 Barisik N.O....Tecimer T. (Diagn Pathol 2010)
    259. Cyclooxygenase-2 expression in non-Hodgkin's lymphomas. (PubMed id 17325901)1, 9 Paydas S....Seydaoglu G. (amp 2007)
    260. Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner. (PubMed id 17635918)1, 9 Jang B.C....Suh S.I. (J. Biol. Chem. 2007)
    261. Site-specific proteolysis of cyclooxygenase-2: a putative step in inflammatory prostaglandin E(2) biosynthesis. (PubMed id 17177291)1, 9 Mancini A....Di Battista J.A. (J. Cell. Biochem. 2007)
    262. Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. (PubMed id 16243808)1, 9 Mrena J....Haglund C. (Clin. Cancer Res. 2005)
    263. Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. (PubMed id 16083499)1, 9 Yoshida S....Adrian T.E. (Mol. Cancer 2005)
    264. The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. (PubMed id 14566822)1, 9 Park S.W....Sung M.W. (Int. J. Cancer 2003)
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    266. Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. (PubMed id 18498876)1, 9 Singh B....Lucci A. (J. Surg. Res. 2008)
    267. The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. (PubMed id 18320325)1, 9 Zhang H....Wang S. (Dig. Dis. Sci. 2008)
    268. Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma. (PubMed id 18705402)1, 9 Do S.I....Park Y.K. (Tumori 2008)
    269. Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. (PubMed id 17341442)1, 9 Cao Z....Jiang B.H. (Cell. Signal. 2007)
    270. The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. (PubMed id 17429597)1, 9 Neuss H....Dubiel W. (J. Mol. Med. 2007)
    271. EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. (PubMed id 18032824)1, 9 Konstantinopoulos P.A....Papavassiliou A.G. (Cell. Oncol. 2007)
    272. Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. (PubMed id 16551850)1, 9 Castells A....PiquAc J.M. (Clin. Cancer Res. 2006)
    273. Expression of cyclooxygenase isoforms in developing rat placenta, human term placenta, and BeWo human trophoblast model. (PubMed id 16323955)1, 9 Xu Y....Cook T.J. (Mol. Pharm. 2005)
    274. Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. (PubMed id 16044148)1, 9 Yang W.L....Xu X.X. (Oncogene 2005)
    275. Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. (PubMed id 15695237)1, 9 Nosho K....Imai K. (Carcinogenesis 2005)
    276. Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. (PubMed id 15754118)1, 9 Sivula A....Turpeenniemi-Hujanen T. (Breast Cancer Res. Treat. 2005)
    277. Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells. (PubMed id 15569819)1, 9 Michaelis U.R....Fleming I. (Arterioscler. Thromb. Vasc. Biol. 2005)
    278. Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. (PubMed id 15010822)1, 9 Cheng A.S....Sung J.J. (Int. J. Oncol. 2004)
    279. Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas. (PubMed id 15569051)1, 9 Hemmerlein B....Heuser M. (Histopathology 2004)
    280. Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer. (PubMed id 15228443)1, 9 Witton C.J....Bartlett J.M. (Histopathology 2004)
    281. Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. (PubMed id 14760075)1, 9 Erkinheimo T.L....RistimAoki A. (Clin. Cancer Res. 2004)
    282. Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. (PubMed id 15231484)1, 9 Souza R.F....Spechler S.J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2004)
    283. Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF. (PubMed id 12881220)1, 9 Wu G....Li J. (Am. J. Physiol. Heart Circ. Physiol. 2003)
    284. Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. (PubMed id 12532441)1, 9 Xue Y.W....Fu S.B. (World J. Gastroenterol. 2003)
    285. Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. (PubMed id 12532440)1, 9 Guo X.L....Yuan Y. (World J. Gastroenterol. 2003)
    286. Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu expression in ovarian cancer. (PubMed id 11972392)1, 9 Ferrandina G....Scambia G. (Gynecol. Oncol. 2002)
    287. Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma. (PubMed id 19039588)1, 9 Johansson C.C....Kiessling R. (Cancer Immunol. Immunother. 2009)
    288. Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. (PubMed id 18181047)1, 9 Tang H....Fan D. (Cancer Invest. 2008)
    289. Coexpression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor: possible relations to pathological parameters and clinical behavior. (PubMed id 19260469)1, 9 Miao R....Li J. (Hepatogastroenterology 2008)
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    291. Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. (PubMed id 17332916)1, 9 Simeone A.M....Tari A.M. (Int. J. Oncol. 2007)
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    293. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. (PubMed id 15222037)1, 9 Kasper H.U....Kern M.A. (World J. Gastroenterol. 2004)
    294. COX-2 status in relation to tumor microvessel density and VEGF expression: analysis in ovarian carcinoma patients with low versus high survival rates. (PubMed id 14719060)1, 9 Raspollini M.R....Taddei G.L. (Oncol. Rep. 2004)
    295. Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells. (PubMed id 15210717)1, 9 Kim S.Y....Min D.S. (J. Biol. Chem. 2004)
    296. Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. (PubMed id 15222024)1, 9 Li H.L....Ma F.C. (World J. Gastroenterol. 2004)
    297. Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. (PubMed id 12883661)1, 9 Lim S.C....Do N.Y. (Oncol. Rep. 2003)
    298. Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. (PubMed id 12883688)1, 9 Lim S.C. (Oncol. Rep. 2003)
    299. Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. (PubMed id 12839952)1, 9 Liu W....Ellis L.M. (Cancer Res. 2003)
    300. Expression of cyclooxygenase-2 in eutopic endometrium and ovarian endometriotic tissue in women with severe endometriosis. (PubMed id 20068324)1, 9 Cho S....Lee B.S. (Gynecol. Obstet. Invest. 2010)
    301. Differential expression of cyclooxygenases in hypertrophic scar and keloid tissues. (PubMed id 19769727)1, 9 Rossiello L....Rossiello R. (Wound Repair Regen 2009)
    302. Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines. (PubMed id 19940363)1, 9 Sitarz R....Milne A.N. (Cell. Oncol. 2009)
    303. Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors. (PubMed id 19845533)1, 9 TA1rkAPz H.K....Ozcan D. (APMIS 2009)
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    306. Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. (PubMed id 18663571)1, 9 Lucci A....Cristofanilli M. (Breast Cancer Res. Treat. 2009)
    307. Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis. (PubMed id 18053993)1, 9 Ceyhan S.T....Gunhan O. (Fertil. Steril. 2008)
    308. Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cells. (PubMed id 18212353)1, 9 Casciani V....Challis J.R. (Reprod Sci 2008)
    309. Prognostic value of COX-2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer. (PubMed id 19132985)1, 9 Zafirellis K....Zachaki A. (APMIS 2008)
    310. COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells. (PubMed id 18093816)1, 9 Futagami S....Sakamoto C. (Prostaglandins Leukot. Essent. Fatty Acids 2008)
    311. Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. (PubMed id 17511025)1, 9 Yoshikawa R....Tsujimura T. (World J. Gastroenterol. 2007)
    312. Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction. (PubMed id 17868881)1, 9 Zidar N....Stajer D. (Cardiovasc. Pathol. 2007)
    313. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. (PubMed id 17693978)1, 9 Maes M....Bosmans E. (Neuro Endocrinol. Lett. 2007)
    314. YKL-40 in human lumbar herniated disc and its relationships with nitric oxide and cyclooxygenase-2. (PubMed id 17631744)1, 9 Pozzuoli A....Punzi L. (Clin. Exp. Rheumatol. 2007)
    315. Analysis of renal immunoexpression of cyclooxygenase-1 and cyclooxygenase-2 in lupus and nonlupus membranous glomerulopathy. (PubMed id 18459455)1, 9 Danilewicz M. and Wagrowska-Danilewicz M. (Pol J Pathol 2007)
    316. Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma. (PubMed id 16169726)1, 9 Cho M.H....Min K.W. (Breast 2006)
    317. Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis. (PubMed id 16456945)1, 9 Chou Y.C....Yuan C.C. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2006)
    318. Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. (PubMed id 17192687)1, 9 Mohammad A.M....Eiman G. (Indian J Cancer 2006)
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    321. Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa. (PubMed id 15720413)1, 9 Bhandari P....Patel P. (Histopathology 2005)
    322. Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. (PubMed id 14742690)7, 9 Mifflin R.C....Powell D.W. (Mol. Pharmacol. 2004)
    323. The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis. (PubMed id 15301234)1, 9 StudA1nkovA! J.T....Gay S. (Clin. Exp. Rheumatol. 2004)
    324. Expression of cyclooxygenase-2 and its correlation with clinicopathologic factors of ampulla of vater cancer. (PubMed id 12692419)1, 9 Kim H.J....Rhee J.C. (J. Korean Med. Sci. 2003)
    325. PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells. (PubMed id 12754192)1, 9 Chambers L.S....Burgess J.K. (Am. J. Physiol. Lung Cell Mol. Physiol. 2003)
    326. Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis. (PubMed id 12970891)1, 9 Wu A.W....Xu G.W. (World J. Gastroenterol. 2003)
    327. [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma]. (PubMed id 12667327)1, 9 Pang D....Xue Y. (Zhonghua Zhong Liu Za Zhi 2002)
    328. p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells. (PubMed id 20204301)1, 9 Shan Y....Bao Y. (Oncol. Rep. 2010)
    329. Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. (PubMed id 19280060)1, 9 Guo X....Yu X. (Acta Biochim. Biophys. Sin. (Shanghai) 2009)
    330. Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesions. (PubMed id 19917472)1, 9 Horn L.C....Leo C. (Ann Diagn Pathol 2009)
    331. COX-2 expression does not correlate with microvessel density in breast cancer. (PubMed id 19188749)1, 9 Thorat M.A....Badve S. (Pathobiology 2009)
    332. Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. (PubMed id 18985541)1, 9 Bartchewsky W....Ribeiro M.L. (Scand. J. Gastroenterol. 2009)
    333. [Expression of COX-2 and VEGF-C in papillary thyroid carcinoma and their relationship to cervical lymph metastases]. (PubMed id 20120873)1, 9 Miao A....Cheng L. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009)
    334. Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. (PubMed id 19244345)1, 9 Rodriguez D.A....Quest A.F. (Mol. Biol. Cell 2009)
    335. Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. (PubMed id 19608016)1, 9 Di J.M....Ruan X.X. (Arch. Med. Res. 2009)
    336. Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways. (PubMed id 19299454)1, 9 Carli C....Akoum A. (Endocrinology 2009)
    337. COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. (PubMed id 18753249)1, 9 Harrington L.S....Mitchell J.A. (FASEB J. 2008)
    338. Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. (PubMed id 18373164)1, 9 Futagami S....Sakamoto C. (J. Gastroenterol. 2008)
    339. Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells. (PubMed id 18565510)1, 9 Liou J.T....Lai J.H. (Eur. J. Pharmacol. 2008)
    340. Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. (PubMed id 18190720)1, 9 Zhang X.H....Chen S.Y. (BMC Cancer 2008)
    341. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. (PubMed id 18565574)1, 9 Hammes L.S....Cunha-Filho J.S. (Gynecol. Oncol. 2008)
    342. Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. (PubMed id 18334709)1, 9 Visscher D.W....Hartmann L.C. (J. Natl. Cancer Inst. 2008)
    343. Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells. (PubMed id 17982644)1, 9 Chan M.W....Leung W.K. (Oncol. Rep. 2007)
    344. [Correlation of cyclooxygenase 2 with upstream mitogen-activated protein kinase, nuclear factor kappa B signal transduction pathway in middle turbinate mucosa of chronic rhinosinusitis]. (PubMed id 17702421)1, 9 Wang Z.L....Wei Y. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007)
    345. Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells. (PubMed id 17868457)1, 9 Shelby B.D....Sullivan D.E. (Virol. J. 2007)
    346. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. (PubMed id 16570043)1, 9 Timoshenko A.V....Lala P.K. (Br. J. Cancer 2006)
    347. A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells. (PubMed id 17156488)1, 9 Basu G.D....Mukherjee P. (Breast Cancer Res. 2006)
    348. PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. (PubMed id 16215757)1, 9 Vandoros G.P....Papavassiliou A.G. (J. Cancer Res. Clin. Oncol. 2006)
    349. Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. (PubMed id 16984258)1, 9 Zhang Q....Travers J.B. (Exp. Dermatol. 2006)
    350. Contribution of inducible nitric oxide synthase and cyclooxygenase-2 to apoptosis induction in smooth chorion trophoblast cells of human fetal membrane tissues. (PubMed id 16442500)1, 9 Yuan B....Toyoda H. (Biochem. Biophys. Res. Commun. 2006)
    351. Increased cyclooxygenase-2 expression is associated with better clinical outcome in patients submitted to complete ablation for severe endometriosis. (PubMed id 15979990)1, 9 Fanfani F....Scambia G. (Hum. Reprod. 2005)
    352. Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression. (PubMed id 16101131)1, 9 Uefuji K....Mochizuki H. (Anticancer Res. 2005)
    353. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. (PubMed id 15767259)1, 9 Kim H....LaMont J.T. (J. Biol. Chem. 2005)
    354. Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. (PubMed id 15704107)1, 9 Yuan A....Yang P.C. (Int. J. Cancer 2005)
    355. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. (PubMed id 15655513)7, 9 Esser R....Marshall P.J. (Br. J. Pharmacol. 2005)
    356. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. (PubMed id 15896711)1, 9 Hwang J.T....Park O.J. (Biochem. Biophys. Res. Commun. 2005)
    357. Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis. (PubMed id 16097070)1, 9 Yu J.R....Zheng S.S. (World J. Gastroenterol. 2005)
    358. Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. (PubMed id 15330183)1, 9 Ranger G.S....Mokbel K. (Anticancer Res. 2004)
    359. COX-2 expression and tumor angiogenesis in colorectal cancer. (PubMed id 15285012)1, 9 Wu A.W....Xu G.W. (World J. Gastroenterol. 2004)
    360. [Research on relationships of gastric cancer with serum trace elements, Helicobacter pylori and COX-2 in gastric tissue]. (PubMed id 15022477)1, 9 Li Y....Zhou Y. (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2004)
    361. Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells. (PubMed id 15331599)1, 9 Pawliczak R....Shelhamer J.H. (J. Biol. Chem. 2004)
    362. Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets. (PubMed id 15471850)1, 9 Heitmeier M.R....Maziasz T.J. (J. Biol. Chem. 2004)
    363. Reciprocal expression of peroxisome proliferator-activated receptor-gamma and cyclooxygenase-2 in human term parturition. (PubMed id 15042019)1, 9 Dunn-Albanese L.R....Kniss D.A. (Am. J. Obstet. Gynecol. 2004)
    364. [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis]. (PubMed id 14989896)1, 9 Yu H.P....Xu S.Q. (Zhonghua Yu Fang Yi Xue Za Zhi 2004)
    365. Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. (PubMed id 12957358)1, 9 Yu H.P....Li Y.Y. (Cancer Lett. 2003)
    366. Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. (PubMed id 12800231)1, 9 Xiong B....Cheng F.L. (World J. Gastroenterol. 2003)
    367. Immunohistochemical analysis of cyclooxygenase-2 and vascular endothelial growth factor in pancreaticobiliary maljunction. (PubMed id 12579269)1, 9 Tsuchida A....Koyanagi Y. (Oncol. Rep. 2003)
    368. Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. (PubMed id 14607721)1, 9 Wu G.S....Zou S.Q. (amp 2002)
    369. Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. (PubMed id 11957147)1, 9 Fujiwaki R....Miyazaki K. (Hum. Pathol. 2002)
    370. Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging. (PubMed id 12162677)1, 9 Maitra A....Wilentz R.E. (Am. J. Clin. Pathol. 2002)
    371. Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. (PubMed id 11920515)1, 9 Niijima M....Saisho H. (Cancer 2002)
    372. PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. (PubMed id 20032081)1, 9 Scoditti E....De Caterina R. (Cardiovasc. Res. 2010)
    373. Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in gastric mucosa with intestinal metaplasia or dysplasia. (PubMed id 20492336)1, 9 Liu D....Liu C. (J. Gastroenterol. Hepatol. 2010)
    374. Overexpression of cyclooxygenase-2 in urothelial carcinoma in conjunction with tumor-associated-macrophage infiltration, hypoxia-inducible factor-1alpha expression, and tumor angiogenesis. (PubMed id 19245590)1, 9 Chen W.T....Chai C.Y. (APMIS 2009)
    375. HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. (PubMed id 19638428)1, 9 Moore A.E....Paraskeva C. (Carcinogenesis 2009)
    376. [Expression of cyclooxygenase-2 in bone marrow cells of leukemia patients and its association with angiogenesis]. (PubMed id 19236744)1, 9 Liu X.W....Zhang D.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    377. Expression of cyclooxygenase-2 and matrix metalloproteinase-2 in adenomyosis and endometrial polyps and its correlation with angiogenesis. (PubMed id 19188819)1, 9 Tokyol C....Arioz D.T. (Int. J. Gynecol. Pathol. 2009)
    378. Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. (PubMed id 19925030)1, 9 Zhang J....Kang C.S. (amp 2009)
    379. Involvement of mitogen-activated protein kinases and nuclear factor kappa B pathways in signaling COX-2 expression in chronic rhinosinusitis. (PubMed id 19319478)1, 9 Wang Z....Li Y. (Inflamm. Res. 2009)
    380. Protein kinase D mediates synergistic expression of COX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts. (PubMed id 19794144)1, 9 Yoo J....Rozengurt E. (Am. J. Physiol., Cell Physiol. 2009)
    381. Celecoxib potentiates the anticancer effect of cisplatin on vulvar cancer cells independently of cyclooxygenase. (PubMed id 19723114)1, 9 Kim S.H....Song Y.S. (Ann. N. Y. Acad. Sci. 2009)
    382. Expression of prostaglandin metabolising enzymes COX-2 and 15-PGDH and VDR in human granulosa cells. (PubMed id 19667156)1, 9 Thill M....Friedrich M. (Anticancer Res. 2009)
    383. [Effects of celecoxib on PGE2 synthesis and COX-2 and VEGF-C mRNA expression in Tca8113 cell lines]. (PubMed id 19304526)1, 9 Li W.Z....Ding Y.Q. (Nan Fang Yi Ke Da Xue Xue Bao 2009)
    384. The role of COX-2 in rectal cancer treated with preoperative radiotherapy. (PubMed id 18392637)1, 9 Bouzourene H....Coucke P. (Virchows Arch. 2008)
    385. Cyclooxygenase-2 expression during immortalization and breast cancer progression. (PubMed id 18199541)1, 9 Zhao X....Band V. (Cancer Res. 2008)
    386. Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2. (PubMed id 18029351)1, 9 Xu L....Wu T. (J. Biol. Chem. 2008)
    387. Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. (PubMed id 18237405)1, 9 Xu F....Shen H. (Respir. Res. 2008)
    388. Inhibitory effect of interferon-alpha-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice. (PubMed id 19058305)1, 9 Cao B....Shi Z.L. (World J. Gastroenterol. 2008)
    389. Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. (PubMed id 18758643)1, 9 LazA8r D....Vernic C. (Rom J Morphol Embryol 2008)
    390. [Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis]. (PubMed id 18950008)1, 9 Cui D....Fu Y. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    391. Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. (PubMed id 17671679)1, 9 Noriyuki M....Ishiko O. (Int. J. Oncol. 2007)
    392. Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1. (PubMed id 17968936)1, 9 JA1ngel A....Distler J.H. (Arthritis Rheum. 2007)
    393. Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium. (PubMed id 17012371)1, 9 N'Guessan P.D....Hippenstiel S. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    394. [Relationship between serum VEGF level and VEGF, COX-2 and MVD expression in breast cancer tissues]. (PubMed id 18069633)1, 9 Li E.X....Dong D.F. (Zhonghua Zhong Liu Za Zhi 2007)
    395. Expression of cyclooxygenase-2 and vascular endothelial growth factor in primary central nervous system lymphomas. (PubMed id 17671709)1, 9 Sugita Y....Nakashima A. (Oncol. Rep. 2007)
    396. EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality. (PubMed id 17290397)1, 9 Gustafsson A....Lundholm K. (Int. J. Cancer 2007)
    397. Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results. (PubMed id 16786043)1, 9 Mascaux C....Sculier J.P. (Br. J. Cancer 2006)
    398. PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. (PubMed id 16820889)1, 9 Ikezoe T....Koeffler H.P. (Int. J. Oncol. 2006)
    399. Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. (PubMed id 16733863)1, 9 Legan M....Cor A. (World J. Gastroenterol. 2006)
    400. Molecular determinants in targeted therapy for esophageal adenocarcinoma. (PubMed id 16702519)1, 9 VallbAPhmer D....DeMeester T.R. (Arch Surg 2006)
    401. Overexpression of cyclooxygenase-2 correlates with tumor angiogenesis in endometrial carcinoma. (PubMed id 16884383)1, 9 Li W....Jiang L.H. (Int. J. Gynecol. Cancer 2006)
    402. COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. (PubMed id 15272284)1, 9 Kyzas P.A....Agnantis N.J. (Mod. Pathol. 2005)
    403. Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. (PubMed id 16168133)1, 9 Surowiak P....Lage H. (Breast Cancer Res. 2005)
    404. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. (PubMed id 15863442)1, 9 Martey C.A....Phipps R.P. (Am. J. Physiol. Lung Cell Mol. Physiol. 2005)
    405. Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. (PubMed id 15645120)1, 9 Kuroda J....Hashimoto-Tamaoki T. (Int. J. Oncol. 2005)
    406. The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta}. (PubMed id 15784717)1, 9 Sooranna S.R....Johnson M.R. (J. Clin. Endocrinol. Metab. 2005)
    407. Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. (PubMed id 16278387)1, 9 Dalwadi H....Dubinett S. (Clin. Cancer Res. 2005)
    408. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. (PubMed id 16203768)1, 9 Cianchi F....Masini E. (Clin. Cancer Res. 2005)
    409. COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. (PubMed id 14735188)1, 9 Boland G.P....Bundred N.J. (Br. J. Cancer 2004)
    410. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. (PubMed id 14769824)1, 9 Kuwano T....Ono M. (FASEB J. 2004)
    411. Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium. (PubMed id 15533352)1, 9 Matsuzaki S....Mage G. (Fertil. Steril. 2004)
    412. Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. (PubMed id 15102673)1, 9 Cianchi F....Masini E. (Clin. Cancer Res. 2004)
    413. Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts. (PubMed id 15246970)1, 9 Miura S....Sakamoto C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2004)
    414. Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. (PubMed id 15259059)1, 9 Jiang J.G....Wang D.W. (World J. Gastroenterol. 2004)
    415. Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. (PubMed id 14747187)1, 9 Fagotti A....Scambia G. (Hum. Reprod. 2004)
    416. Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts. (PubMed id 15106733)7, 9 Chae H.J....Kim H.R. (Immunopharmacol Immunotoxicol 2004)
    417. Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. (PubMed id 12727794)1, 9 MaihAPfner C....Gooderham N.J. (Carcinogenesis 2003)
    418. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. (PubMed id 12939602)1, 9 Leng J....Wu T. (Hepatology 2003)
    419. Variation in cyclooxygenase expression levels within the colorectum. (PubMed id 12720297)1, 9 Wiese F.W....Kadlubar F.F. (Mol. Carcinog. 2003)
    420. Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas. (PubMed id 14550281)1, 9 Hur K....Yang H.K. (Biochem. Biophys. Res. Commun. 2003)
    421. Cyclooxygenase-2 inhibitor NS398 enhances antitumor effect of irradiation on hormone refractory human prostate carcinoma cells. (PubMed id 14532848)1, 9 Wen B....Bourhis J. (J. Urol. 2003)
    422. Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. (PubMed id 12591723)1, 9 Heuze-Vourc'h N....Dubinett S.M. (Cancer Res. 2003)
    423. ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells. (PubMed id 12761889)1, 9 Tsuzaki M....Banes A.J. (J. Cell. Biochem. 2003)
    424. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. (PubMed id 12598658)1, 9 Inaba T....Nakada H. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    425. Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1. (PubMed id 12763047)1, 9 Bakker A.D....Burger E.H. (Biochem. Biophys. Res. Commun. 2003)
    426. Tumor necrosis factor alpha (TNF-alpha)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts. (PubMed id 12349897)1, 9 Nakao S....Sugiya H. (Mol. Cell. Biochem. 2002)
    427. Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. (PubMed id 11939728)1, 9 Nose F....Okayasu I. (Am. J. Clin. Pathol. 2002)
    428. [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior]. (PubMed id 12452062)1, 9 Ji S.Q....Shao Y.F. (Ai Zheng 2002)
    429. Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2). (PubMed id 11006278)7, 9 Smith T....DeWitt D. (J. Biol. Chem. 2000)
    430. Structure-based design of COX-2 selectivity into flurbiprofen. (PubMed id 10091674)7, 9 Bayly C.I....Percival M.D. (amp 1999)
    431. Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: correlation with tumor angiogenesis. (PubMed id 19497798)1, 9 Cianchi F....Masini E. (Dig Liver Dis 2010)
    432. Cigarette smoke and increased COX-2 and survivin levels in exhaled breath condensate of lung cancer patients: how hot is the link? (PubMed id 19423183)1, 9 Carpagnano G.E....Foschino Barbaro M.P. (Lung Cancer 2010)
    433. The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. (PubMed id 20514410)1, 9 Patsos H.A....Williams A.C. (Int. J. Oncol. 2010)
    434. COX-2 expression in uterine carcinosarcoma. (PubMed id 19900134)1, 9 Menczer J....Levy T. (Acta Obstet Gynecol Scand 2010)
    435. Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis. (PubMed id 19277703)1, 9 Huh J.W....Kim Y.J. (Virchows Arch. 2009)
    436. [Expressions of vascular endothelial growth factor and cyclooxygenase-2 in patients with multiple myeloma and its significance]. (PubMed id 19236756)1, 9 Bao H.Y....Ruan C.G. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    437. Expression of cyclooxygenase-1 and -2 in IL-1beta-induced synovitis of the temporomandibular joint. (PubMed id 19141058)1, 9 Satoh K....Kondoh T. (amp 2009)
    438. Glucocorticoid therapy increases COX-2 gene expression in nasal polyps in vivo. (PubMed id 19251796)1, 9 Pujols L....Picado C. (Eur. Respir. J. 2009)
    439. Cross-talk between inducible nitric oxide synthase and cyclooxygenase in Helicobacter-pylori-induced gastritis. (PubMed id 19797925)1, 9 Franco L. and Talamini G. (Med Princ Pract 2009)
    440. Critical role of COX-1 in prostacyclin production by human endothelial cells under modification of hydroperoxide tone. (PubMed id 18838483)1, 9 Bolego C....Sala A. (FASEB J. 2009)
    441. Tpl-2/Cot and COX-2 in breast cancer. (PubMed id 18795070)1, 9 Krcova Z....Kolar Z. (Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2008)
    442. Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells. (PubMed id 17889855)1, 9 Tsai E.M....Lee J.N. (Fertil. Steril. 2008)
    443. Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. (PubMed id 19088039)1, 9 Ogino S....Fuchs C.S. (Clin. Cancer Res. 2008)
    444. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. (PubMed id 18469157)1, 9 Dillon M.F....Young L.S. (Endocr. Relat. Cancer 2008)
    445. Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. (PubMed id 18356024)1, 9 Pandey M....Pillai R.M. (Int J Oral Maxillofac Surg 2008)
    446. Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer. (PubMed id 18000398)1, 9 Matsubayashi H....Goggins M. (amp 2007)
    447. Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. (PubMed id 17594159)1, 9 Lim S.C....Min Y.D. (Yonsei Med. J. 2007)
    448. Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas. (PubMed id 17592548)1, 9 Wu R....Steinberg B.M. (Mol. Med. 2007)
    449. Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. (PubMed id 17711445)1, 9 Yuri M....Kuniyasu H. (Histopathology 2007)
    450. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. (PubMed id 17881124)1, 9 Boetkjaer A....Lukiw W.J. (Neurosci. Lett. 2007)
    451. Prostacyclin production is not controlled by prostacyclin synthase but by cyclooxygenase-2 in a human follicular dendritic cell line, HK. (PubMed id 17337058)1, 9 Lee I.Y....Choe J. (Mol. Immunol. 2007)
    452. [COX-2 and mPGES-1 expression in carotid atherosclerotic plaques]. (PubMed id 17680542)1, 9 Liu H.F....Zhang F.Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
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    455. Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. (PubMed id 16393343)1, 9 Durrenberger P.F....Anand P. (BMC Neurol 2006)
    456. RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor. (PubMed id 16731743)1, 9 Narayanan B.A....Nargi D. (Mol. Cancer Ther. 2006)
    457. Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray. (PubMed id 16481301)1, 9 Xu L....Gao H.J. (amp 2006)
    458. IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer. (PubMed id 16574063)1, 9 Cui X....Dubinett S.M. (Biochem. Biophys. Res. Commun. 2006)
    459. Expression of cyclooxygenase-2 in epithelial ovarian tumors and its relation to vascular endothelial growth factor and p53 expression. (PubMed id 16515599)1, 9 Lee J.S....Min K.W. (Int. J. Gynecol. Cancer 2006)
    460. Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. (PubMed id 16343055)1, 9 Grau R....IA+iguez M.A. (Biochem. J. 2006)
    461. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. (PubMed id 16505480)1, 9 Yiu G.K. and Toker A. (J. Biol. Chem. 2006)
    462. Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. (PubMed id 15864753)1, 9 Huang S.P....Lin J.T. (J. Biomed. Sci. 2005)
    463. Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells. (PubMed id 15878911)1, 9 Abdalla S.I....Fitzgerald R.C. (Carcinogenesis 2005)
    464. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. (PubMed id 16087791)1, 9 McAdam B.F....Oates J.A. (Circulation 2005)
    465. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. (PubMed id 15632146)1, 9 Duque J....IA+iguez M.A. (J. Biol. Chem. 2005)
    466. The use and safety profile of non-steroidal antiinflammatory drugs among Turkish patients with osteoarthritis. (PubMed id 16245223)7, 9 Yilmaz H....Ozdemir O. (Turk J Gastroenterol 2005)
    467. Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. (PubMed id 15713675)1, 9 Tong X....Giardina C. (J. Biol. Chem. 2005)
    468. Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. (PubMed id 15856454)1, 9 Sivula A....RistimAoki A. (Int. J. Cancer 2005)
    469. Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. (PubMed id 16005433)1, 9 Lee J....Park K. (Biochem. Biophys. Res. Commun. 2005)
    470. Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. (PubMed id 15550400)1, 9 Liu X.H....Levine A.C. (J. Biol. Chem. 2005)
    471. Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. (PubMed id 15598423)7, 9 Payvandi F....Stirling D.I. (Cell. Immunol. 2004)
    472. Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. (PubMed id 15334675)1, 9 Sun W.H....Su H. (World J. Gastroenterol. 2004)
    473. Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. (PubMed id 15355919)1, 9 Adegboyega P.A....Powell D.W. (Clin. Cancer Res. 2004)
    474. Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. (PubMed id 15102535)7, 9 Padi S.S....Kulkarni S.K. (Eur. J. Pharmacol. 2004)
    475. Cyclooxygenase-2 parallels invasive depth and increased MVD in transitional cell carcinoma. (PubMed id 15450303)1, 9 Li G....Zhang Y. (Colloids Surf B Biointerfaces 2004)
    476. [Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression]. (PubMed id 15730717)7, 9 Zhang G.S....Xia M. (Zhonghua Xue Ye Xue Za Zhi 2004)
    477. Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. (PubMed id 15151617)1, 9 Yu H.P....Xu S.Q. (J. Gastroenterol. Hepatol. 2004)
    478. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. (PubMed id 15063780)1, 9 Tong X....Giardina C. (Biochem. Biophys. Res. Commun. 2004)
    479. [COX-2-expression in extragenital endometriosis lesions as a novel therapeutical approach?]. (PubMed id 14505259)1, 9 Bartley J....Ebert A.D. (Zentralbl Gynakol 2003)
    480. PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. (PubMed id 12821125)1, 9 Eibl G....Hines O.J. (Biochem. Biophys. Res. Commun. 2003)
    481. Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. (PubMed id 12679908)1, 9 Li H.X....He S.X. (World J. Gastroenterol. 2003)
    482. Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer. (PubMed id 12533667)1, 9 Chu J....Rizzo M.T. (Mol. Cancer Ther. 2003)
    483. Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. (PubMed id 12954496)1, 9 Gee J.R....Grossman H.B. (Urol. Oncol. 2003)
    484. Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. (PubMed id 12907138)1, 9 Jiang W.G....Mansel R.E. (Prostaglandins Leukot. Essent. Fatty Acids 2003)
    485. Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. (PubMed id 12592372)1, 9 Spizzo G....Obrist P. (Br. J. Cancer 2003)
    486. [Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer]. (PubMed id 12600292)1, 9 Chen Z.K. and Ouyang Z.T. (Ai Zheng 2003)
    487. Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. (PubMed id 11809750)1, 9 Pontsler A.V....McIntyre T.M. (J. Biol. Chem. 2002)
    488. Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. (PubMed id 11844819)1, 9 Ferrandina G....Ranelletti F.O. (J. Clin. Oncol. 2002)
    489. Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. (PubMed id 12393863)1, 9 Zeng Q....Wang C.Y. (J. Biol. Chem. 2002)
    490. Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. (PubMed id 11948128)1, 9 Asano T....Miwa M. (Clin. Cancer Res. 2002)
    491. Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. (PubMed id 12324457)1, 9 Lim J.W....Kim K.H. (J. Biol. Chem. 2002)
    492. Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. (PubMed id 10657949)7, 9 Yip-Schneider M.T....Sweeney C.J. (Carcinogenesis 2000)
    493. Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects. (PubMed id 10381787)7, 9 Panara M.R....Patrignani P. (J. Pharmacol. Exp. Ther. 1999)
    494. Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebo controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group. (PubMed id 10555907)7, 9 Ehrich E.W....Gertz B.J. (J. Rheumatol. 1999)
    495. Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial. (PubMed id 10566562)7, 9 Malmstrom K....Desjardins P.J. (Clin Ther 1999)
    496. Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage. (PubMed id 20405237)1, 9 Shan Y....Wang S. (Cardiovasc. Toxicol. 2010)
    497. Progress in COX-2 inhibitors: a journey so far. (PubMed id 20166930)7, 9 Chakraborti A.K....Jadhavar P.S. (Curr. Med. Chem. 2010)
    498. Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer. (PubMed id 20397266)1, 9 Hermanova M....Dite P. (World J. Gastroenterol. 2010)
    499. Localization of cyclo-oxygenase-2 in human recurrent colorectal cancer. (PubMed id 20144265)1, 9 Loukanov T.s....MA1ller-Decker K. (Clin Invest Med 2010)
    500. Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. (PubMed id 20372792)1, 9 Lepage C....Beneytout J.L. (Int. J. Oncol. 2010)
    501. Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells. (PubMed id 19618291)1, 9 Di J.M....Gao X. (Mol. Biol. Rep. 2010)
    502. Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. (PubMed id 20514441)1, 9 Ohtsu N....Urade M. (Oncol. Rep. 2010)
    503. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. (PubMed id 19723094)1, 9 Lee Y.K....Park O.J. (Ann. N. Y. Acad. Sci. 2009)
    504. The relationship between cyclooxygenase-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma. (PubMed id 19816074)1, 9 Liu W.K....Zhang Z.X. (Onkologie 2009)
    505. Nicotinamide phosphoribosyltransferase and prostaglandin H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells after stimulation with interleukin-1. (PubMed id 19513556)1, 9 Bauer L....Radons J. (Int. J. Oncol. 2009)
    506. [Effect of clarithromycin on the expressions of cyclooxygenase-2 and nuclear factor-kappa B in nasal polyps in vitro]. (PubMed id 20030038)1, 9 Zhang M....Zhang Q. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009)
    507. The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways. (PubMed id 19467701)1, 9 Chang M.C....Jeng J.H. (Biomaterials 2009)
    508. Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. (PubMed id 19505922)1, 9 Takai T....Hishida A. (amp 2009)
    509. The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. (PubMed id 19491270)1, 9 Yeh T.S....Chi C.W. (Cancer Res. 2009)
    510. Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. (PubMed id 19218340)1, 9 Itatsu K....Nakanuma Y. (Am. J. Pathol. 2009)
    511. Cyclooxygenase-2 up-regulates ataxia telangiectasia and Rad3 related through extracellular signal-regulated kinase activation. (PubMed id 19584262)1, 9 Kim Y.M....Pyo H. (Mol. Cancer Res. 2009)
    512. Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. (PubMed id 19241124)1, 9 Kurihara Y....Shintani S. (amp 2009)
    513. Correlation of cyclooxygenase 2 expression and inflammatory cells infiltration in colorectal cancer. (PubMed id 19579928)1, 9 Naghshvar F....Ghahremani M. (Pak. J. Biol. Sci. 2009)
    514. Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB. (PubMed id 19940361)1, 9 Zatelli M.C....degli Uberti E. (Cell. Oncol. 2009)
    515. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. (PubMed id 19058955)1, 9 Madden K....Mohammed S.I. (Prostaglandins Leukot. Essent. Fatty Acids 2009)
    516. Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. (PubMed id 19287974)1, 9 Kobayashi H....Danenberg P.V. (Int. J. Oncol. 2009)
    517. MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2. (PubMed id 19846662)1, 9 Hsu K.W....Yeh T.S. (Mol. Biol. Cell 2009)
    518. Matrix Metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps. (PubMed id 17624726)1, 9 Karahan N....Kapucuoglu N. (J Voice 2009)
    519. [Expression of cyclooxygenase-2 and relationship with mismatch repair gene and microsatellite instability in hereditary non-polyposis colorectal cancer]. (PubMed id 19671325)1, 9 Zhang Y.H....Li S.R. (Zhonghua Yi Xue Za Zhi 2009)
    520. [Expression of P53, COX2 and CD44V6 in early-stage squamous carcinoma of cervix with lymph vascular space invasion positive and negative and its relationship with prognosis]. (PubMed id 20193563)1, 9 Zhang R....Wang Y. (Zhonghua Yi Xue Za Zhi 2009)
    521. Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. (PubMed id 19318593)1, 9 Alvarez Y....FernA!ndez N. (J. Pharmacol. Exp. Ther. 2009)
    522. Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma. (PubMed id 19329856)1, 9 Gao Y.W....Chen W. (Digestion 2009)
    523. [The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma]. (PubMed id 19452725)1, 9 Bai W. and Tang J. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009)
    524. Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals. (PubMed id 19723105)1, 9 Lee Y.K....Park O.J. (Ann. N. Y. Acad. Sci. 2009)
    525. Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. (PubMed id 19217709)1, 9 Duarte M.L....Ferreira C.G. (Cancer Lett. 2009)
    526. The effect of cyclooxygenase-2 expression on tumor volume response in patients treated with radiotherapy for uterine cervical cancer. (PubMed id 19949677)1, 9 Kang M.K....Kim B.G. (J. Korean Med. Sci. 2009)
    527. Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways. (PubMed id 19558494)1, 9 Agarwal S....Reddanna P. (Exp. Dermatol. 2009)
    528. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. (PubMed id 19056653)1, 9 Degner S.C....Romagnolo D.F. (J. Nutr. 2009)
    529. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. (PubMed id 18326857)1, 9 Misra S....Ghatak S. (J. Biol. Chem. 2008)
    530. Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication? (PubMed id 18718465)1, 9 Clarkin C.E....Wheeler-Jones C.P. (Exp. Cell Res. 2008)
    531. [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis]. (PubMed id 18250037)1, 9 Li W.Z....Zhang J.H. (Nan Fang Yi Ke Da Xue Xue Bao 2008)
    532. [The expression of COX-2 mRNA and protein in human laryngeal squamous cell carcinoma]. (PubMed id 18800677)1, 9 Chen W....Liu B. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    533. [Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma]. (PubMed id 18841789)1, 9 Cui D....Zhang X. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    534. 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. (PubMed id 18555503)1, 9 Le MAce S....Morfin R. (Steroids 2008)
    535. Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. (PubMed id 18395088)1, 9 Subramaniam D....Anant S. (Gastroenterology 2008)
    536. Cyclooxygenase-2 expression in human thyroid disease. (PubMed id 18362501)1, 9 Lee K.J....Soh E.Y. (J. Endocrinol. Invest. 2008)
    537. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. (PubMed id 18048499)1, 9 Bukulmez O....Mendelson C.R. (Endocrinology 2008)
    538. The prognostic significance of COX-2 and survivin expression in ovarian cancer. (PubMed id 18171606)1, 9 Athanassiadou P....Patsouris E. (Pathol. Res. Pract. 2008)
    539. Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. (PubMed id 18775915)1, 9 Park M.J....Cheong J. (Carcinogenesis 2008)
    540. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. (PubMed id 18202756)1, 9 Niesporek S....Denkert C. (Int. J. Oncol. 2008)
    541. COX-2/EGFR expression and survival among women with adenocarcinoma of the lung. (PubMed id 18453539)1, 9 Van Dyke A.L....Schwartz A.G. (Carcinogenesis 2008)
    542. In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA. (PubMed id 18695918)1, 9 Takaoka K....Urade M. (Oncol. Rep. 2008)
    543. Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. (PubMed id 18462890)1, 9 Yamac D....Koybasioglu F. (Pathol. Res. Pract. 2008)
    544. The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. (PubMed id 18381949)1, 9 Fidler M.J....Bonomi P. (Clin. Cancer Res. 2008)
    545. Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. (PubMed id 17553653)1, 9 Takatori H....Aikou T. (Eur J Surg Oncol 2008)
    546. Relevance of COX-2 gene expression in dementia with lewy bodies associated with Alzheimer pathology. (PubMed id 18307244)1, 9 SaldaA+a M....Marin C. (Mov. Disord. 2008)
    547. Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. (PubMed id 17962194)1, 9 Wang H....MacNaughton W.K. (J. Biol. Chem. 2008)
    548. The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. (PubMed id 18953425)1, 9 Stasinopoulos I....Bhujwalla Z.M. (Neoplasia 2008)
    549. Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. (PubMed id 18319253)1, 9 Pan M.R....Hung W.C. (J. Biol. Chem. 2008)
    550. Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. (PubMed id 18262731)1, 9 Haffty B.G....Reiss M. (Int. J. Radiat. Oncol. Biol. Phys. 2008)
    551. Normal or stress-induced fibroblast senescence involves COX-2 activity. (PubMed id 17560572)1, 9 Zdanov S....Abbadie C. (Exp. Cell Res. 2007)
    552. Increased expression of CCAAT/enhancer-binding protein beta in proliferative inflammatory atrophy of the prostate: relation with the expression of COX-2, the androgen receptor, and presence of focal chronic inflammation. (PubMed id 17570496)1, 9 Wang W....Damber J.E. (Prostate 2007)
    553. Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. (PubMed id 17436372)7, 9 Kim S.J....Um J.Y. (Am. J. Chin. Med. 2007)
    554. [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers]. (PubMed id 18159174)1, 9 Joo H.H....Choi Y.K. (Korean J Gastroenterol 2007)
    555. [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma]. (PubMed id 17672932)1, 9 Liu J.R....Liu J.L. (Ai Zheng 2007)
    556. Expression of glycodelin and cyclooxygenase-2 in human endometrial tissue following three-dimensional culture. (PubMed id 17156191)1, 9 Esfandiari N....Casper R.F. (Am. J. Reprod. Immunol. 2007)
    557. EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. (PubMed id 17616668)1, 9 Xu K. and Shu H.K. (Cancer Res. 2007)
    558. Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients. (PubMed id 17295901)1, 9 Chishima F....Nemoto N. (Am. J. Reprod. Immunol. 2007)
    559. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. (PubMed id 17328065)1, 9 Brechter A.B. and Lerner U.H. (Arthritis Rheum. 2007)
    560. Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. (PubMed id 17581404)1, 9 Baltazar F....Schmitt F.C. (Int. J. Gynecol. Pathol. 2007)
    561. Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus. (PubMed id 16917094)1, 9 Szerafin T....Bagi Z. (Circ. Res. 2006)
    562. Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. (PubMed id 16820089)1, 9 Crowell P.L....Cummings W.O. (Neoplasia 2006)
    563. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. (PubMed id 16846546)7, 9 Waterbury L.D....Jolas T. (Curr Med Res Opin 2006)
    564. Complete and long-lasting regression of disseminated multiple skin melanoma metastases under treatment with cyclooxygenase-2 inhibitor. (PubMed id 16718274)1, 9 Lejeune F.J....RA1egg C. (Melanoma Res. 2006)
    565. Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. (PubMed id 16908593)1, 9 Tsai W.C....Wu L.W. (Mol. Cancer Res. 2006)
    566. Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. (PubMed id 16474989)1, 9 Soumaoro L.T....Sugihara K. (Dis. Colon Rectum 2006)
    567. Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. (PubMed id 16521222)1, 9 Li Y....Martin R.C. (World J. Gastroenterol. 2006)
    568. Significance of COX-2 expression in human esophageal squamous cell carcinoma. (PubMed id 16352617)1, 9 Zhi H....Liu Z. (Carcinogenesis 2006)
    569. Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. (PubMed id 16550596)1, 9 Shimizu D....Danenberg P.V. (Int. J. Cancer 2006)
    570. Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. (PubMed id 16111807)1, 9 Kang S....Song Y.S. (Cancer Lett. 2006)
    571. QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors. (PubMed id 16290292)7, 9 Narsinghani T. and Chaturvedi S.C. (amp 2006)
    572. Partnering between monomers of cyclooxygenase-2 homodimers. (PubMed id 16606823)1, 9 Yuan C....Smith W.L. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    573. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. (PubMed id 16723309)1, 9 Maia H....Coutinho E.M. (Gynecol. Endocrinol. 2006)
    574. Heregulin-alpha and heregulin-beta expression is linked to a COX-2-PGE2 pathway in human gastric fibroblasts. (PubMed id 16357062)1, 9 Nagata K....Sakamoto C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)
    575. Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids. (PubMed id 15869467)1, 9 Ciccoli R....Nigam S. (Biochem. J. 2005)
    576. Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins. (PubMed id 15591227)1, 9 Rabausch K....Weber A.A. (Circ. Res. 2005)
    577. E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. (PubMed id 15800927)1, 9 Boedefeld W.M....Heslin M.J. (Mol. Carcinog. 2005)
    578. Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. (PubMed id 15494548)7, 9 Gierse J.K....Seibert K. (J. Pharmacol. Exp. Ther. 2005)
    579. Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. (PubMed id 16237757)1, 9 Shida D....Nagawa H. (World J. Gastroenterol. 2005)
    580. Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis. (PubMed id 15982930)7, 9 Du G.J....Wang M.W. (Vascul. Pharmacol. 2005)
    581. Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. (PubMed id 15754411)1, 9 Chen X.L....Wang Y.L. (World J. Gastroenterol. 2005)
    582. Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1. (PubMed id 15963597)1, 9 Cheng J....Hada T. (J. Hepatol. 2005)
    583. [The expression of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD]. (PubMed id 16494037)1, 9 Sun X....Zheng C. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2005)
    584. Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis. (PubMed id 16419156)1, 9 Liu N.B....Leng J. (World J. Gastroenterol. 2005)
    585. COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. (PubMed id 15645119)1, 9 Honjo S....Ito H. (Int. J. Oncol. 2005)
    586. Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells. (PubMed id 15950779)1, 9 Moolwaney A.S. and Igwe O.J. (Brain Res. Mol. Brain Res. 2005)
    587. Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. (PubMed id 15756444)1, 9 Takatori H....Aikou T. (Oncol. Rep. 2005)
    588. The role of CCAAT/enhancer-binding protein beta in the transcriptional regulation of COX-2 in human amnion. (PubMed id 16399783)1, 9 Lee Y.S....Bennett P.R. (Mol. Hum. Reprod. 2005)
    589. Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium. (PubMed id 15599594)1, 9 Horn L.C....Leo C. (J. Cancer Res. Clin. Oncol. 2005)
    590. Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia. (PubMed id 15276698)1, 9 Yokota O....Kuroda S. (amp 2004)
    591. Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer. (PubMed id 15374967)1, 9 PA/ld M....Dubinett S.M. (Cancer Res. 2004)
    592. Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: a potential predictor of poor survival. (PubMed id 14977838)1, 9 Kim G.E....Suh C.O. (Clin. Cancer Res. 2004)
    593. Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression. (PubMed id 14555963)1, 9 Bizik J....Vaheri A. (Cell Death Differ. 2004)
    594. Pharmacology and gastrointestinal safety of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor: An integrated study. (PubMed id 15017615)7, 9 Atherton C....Hawkey C.J. (Clin. Gastroenterol. Hepatol. 2004)
    595. Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis. (PubMed id 14726416)1, 9 Tanaka N....Morita I. (Arterioscler. Thromb. Vasc. Biol. 2004)
    596. No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor. (PubMed id 15177307)7, 9 Kalbag J....Rordorf C. (Pharmacol. Res. 2004)
    597. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PubMed id 15574495)1, 9 Yan M.... Markowitz S.D. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    598. Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. (PubMed id 14871981)1, 9 Golijanin D....Dannenberg A.J. (Clin. Cancer Res. 2004)
    599. Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44. (PubMed id 16035618)1, 9 Kinugasa Y....Nagumo M. (amp 2004)
    600. Prognostic role of the ratio between cyclooxygenase-2 in tumor and stroma compartments in cervical cancer. (PubMed id 15131052)1, 9 Ferrandina G....Scambia G. (Clin. Cancer Res. 2004)
    601. Cyclooxygenase-2 expression in the hereditary mixed polyposis syndrome. (PubMed id 15628724)1, 9 Brazowski E....Rozen P. (Dig. Dis. Sci. 2004)
    602. Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products. (PubMed id 12837757)1, 9 Shanmugam N....Natarajan R. (J. Biol. Chem. 2003)
    603. Interaction of rofecoxib and celecoxib with warfarin. (PubMed id 12901032)7, 9 Schaefer M.G....Egan M. (Am J Health Syst Pharm 2003)
    604. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. (PubMed id 15199473)7, 9 Wu K.K. (Semin Vasc Med 2003)
    605. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. (PubMed id 12750248)1, 9 Shim V....Esserman L.J. (Cancer Res. 2003)
    606. Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. (PubMed id 12555215)1, 9 Zaitsu M....Ishii E. (Am. J. Hematol. 2003)
    607. Characterization of celecoxib and valdecoxib binding to cyclooxygenase. (PubMed id 12644588)7, 9 Hood W.F....Monahan J.B. (Mol. Pharmacol. 2003)
    608. Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. (PubMed id 14681319)1, 9 Shim J.Y....Lee K.S. (Mod. Pathol. 2003)
    609. Induction of cyclooxygenase-2 mRNA and protein expression in human pulp cells stimulated with black-pigmented bacteroides. (PubMed id 12701770)1, 9 Chang Y.C....Hsieh Y.S. (J Endod 2003)
    610. Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. (PubMed id 12821538)1, 9 Sennlaub F....Chemtob S. (Circulation 2003)
    611. Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. (PubMed id 12743126)1, 9 Abulencia J.P....Konstantopoulos K. (J. Biol. Chem. 2003)
    612. Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. (PubMed id 12875991)1, 9 Gallo O....Capaccioli S. (Am. J. Pathol. 2003)
    613. Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell lines. (PubMed id 12800245)1, 9 Wu G.S....Wang J.H. (World J. Gastroenterol. 2003)
    614. Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. (PubMed id 12771929)1, 9 Charalambous M.P....Gooderham N.J. (Br. J. Cancer 2003)
    615. p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. (PubMed id 12882963)1, 9 Dean J.L....Saklatvala J. (J. Biol. Chem. 2003)
    616. [Relation between COX-2 protein expression and biologic behavior of ovarian carcinoma]. (PubMed id 12839690)1, 9 Tang L.X....Ma J.W. (Zhonghua Zhong Liu Za Zhi 2003)
    617. Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. (PubMed id 12684668)1, 9 Yu J....Sung J.J. (Int. J. Oncol. 2003)
    618. Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2. (PubMed id 14623265)1, 9 Corazzi T....Gresele P. (Biochem. Biophys. Res. Commun. 2003)
    619. Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. (PubMed id 14596920)1, 9 Ogawa H....Binion D.G. (FEBS Lett. 2003)
    620. Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer. (PubMed id 12855643)1, 9 Davies G....Dowsett M. (Clin. Cancer Res. 2003)
    621. Clinical pharmacology of selective COX-2 inhibitors. (PubMed id 14552704)7, 9 Capone M.L....Patrignani P. (Int J Immunopathol Pharmacol 2003)
    622. Cyclooxygenase-2 expression in the gallbladder of patients with anomalous arrangement of the pancreaticobiliary duct. (PubMed id 12677571)1, 9 Fumino S....Iwai N. (J. Pediatr. Surg. 2003)
    623. Mechanisms of action of paracetamol and related analgesics. (PubMed id 15035793)7, 9 Graham G.G. and Scott K.F. (Inflammopharmacology 2003)
    624. Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. (PubMed id 12698187)1, 9 Maaser K....ScherA1bl H. (Br. J. Cancer 2003)
    625. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. (PubMed id 14507922)1, 9 Qin W....Pasinetti G.M. (J. Biol. Chem. 2003)
    626. Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. (PubMed id 12767532)1, 9 Shoji T....Nakamura S. (Cancer Lett. 2003)
    627. Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. (PubMed id 14675489)1, 9 Carlson M.L....Prescott S.M. (Mol. Cancer 2003)
    628. Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib. (PubMed id 11911965)1, 9 Patti R....Reddy C.D. (Cancer Lett. 2002)
    629. Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human. (PubMed id 12167567)7, 9 Yuan J.J....Findlay J.W. (Drug Metab. Dispos. 2002)
    630. Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. (PubMed id 11809691)1, 9 Sales K.J....Soeters R.P. (Cancer Res. 2002)
    631. Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer. (PubMed id 12197220)1, 9 Badawi A.F....Michael M.S. (Cancer Invest. 2002)
    632. Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma. (PubMed id 11920472)1, 9 HastA1rk S....Lee J.S. (Cancer 2002)
    633. Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. (PubMed id 11901151)1, 9 Subbaramaiah K....Dannenberg A.J. (J. Biol. Chem. 2002)
    634. Increased cyclooxygenase-2 expression in human squamous cell carcinomas of the head and neck and inhibition of proliferation by nonsteroidal anti-inflammatory drugs. (PubMed id 12174888)1, 9 Lee D.W....Kim K.H. (Anticancer Res. 2002)
    635. Significance of cyclooxygenase-2 expression in human primary hepatocellular carcinoma. (PubMed id 12378621)1, 9 Qiu D.K....Chen X.Y. (World J. Gastroenterol. 2002)
    636. An immunohistochemical study of cyclooxygenase (COX)-2 expression in endocrine tumors of the pancreas. (PubMed id 12636104)1, 9 Okami J....Monden M. (amp 2002)
    637. ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. (PubMed id 12143054)1, 9 Endo K....Sirica A.E. (Hepatology 2002)
    638. Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction. (PubMed id 11880271)1, 9 Mifflin R.C....Powell D.W. (Am. J. Physiol., Cell Physiol. 2002)
    639. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. (PubMed id 12218179)1, 9 Rossi D.J....Makela T.P. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    640. Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. (PubMed id 12393872)1, 9 Dohadwala M....Dubinett S.M. (J. Biol. Chem. 2002)
    641. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. (PubMed id 12072439)1, 9 Monick M.M....Hunninghake G.W. (J. Biol. Chem. 2002)
    642. Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens. (PubMed id 11894121)1, 9 Swamy M.V....Rao C.V. (Int. J. Oncol. 2002)
    643. In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain. (PubMed id 12446609)7, 9 Blais V....Rivest S. (Endocrinology 2002)
    644. Recognition of cyclooxygenase-2 (COX-2) active site by NSAIDs: a computer modelling study. (PubMed id 11563332)7, 9 Kothekar V....Mishra J. (amp 2001)
    645. Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. (PubMed id 11687965)1, 9 King J.G. and Khalili K. (Oncogene 2001)
    646. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. (PubMed id 11275997)7, 9 Chen W.S....Yang W.K. (Int. J. Cancer 2001)
    647. Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells. (PubMed id 11913955)1, 9 Goldmann W.H....Sharma C.P. (Cell Biol. Int. 2001)
    648. Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group. (PubMed id 10693877)7, 9 Hawkey C....Mortensen E. (Arthritis Rheum. 2000)
    649. Cyclooxygenase-2 in human perinatal lung. (PubMed id 10813584)1, 9 Lassus P....Andersson S. (Pediatr. Res. 2000)
    650. Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. (PubMed id 10075740)1, 9 Meade E.A....Prescott S.M. (J. Biol. Chem. 1999)
    651. Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state. (PubMed id 10340919)7, 9 Tegeder I....Geisslinger G. (Clin. Pharmacol. Ther. 1999)
    652. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. (PubMed id 10381057)7, 9 Blanco F.J....Galdo F. (J. Rheumatol. 1999)
    653. Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells. (PubMed id 9661070)1, 9 Min Y.K....Pilbeam C.C. (J. Bone Miner. Res. 1998)
    654. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. (PubMed id 7832763)7, 9 Gierse J.K....Seibert K. (Biochem. J. 1995)
    655. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. (PubMed id 20028875)1, 9 Fordyce C....Tlsty T. (Cancer Prev Res (Phila) 2010)
    656. Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. (PubMed id 20167866)1, 9 Lee I.T....Yang C.M. (Am. J. Pathol. 2010)
    657. TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes. (PubMed id 20399617)1, 9 RAosAonen K. and Vaheri A. (J. Dermatol. Sci. 2010)
    658. Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression. (PubMed id 19647233)1, 9 Takenaka Y....Harada T. (Fertil. Steril. 2010)
    659. Human glomerular endothelium: interplay among glucose, free fatty acids, angiotensin II, and oxidative stress. (PubMed id 19864304)1, 9 Jaimes E.A....Raij L. (Am. J. Physiol. Renal Physiol. 2010)
    660. COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-beta, IL-10 and Ki67. (PubMed id 20409773)1, 9 Richardsen E....Busund L.T. (Cancer Epidemiol 2010)
    661. The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy. (PubMed id 19887674)1, 9 Dragani A....Rocca B. (Blood 2010)
    662. Decreased TGFbeta signaling and increased COX2 expression in high risk women with increased mammographic breast density. (PubMed id 19241157)1, 9 Yang W.T....Chang J.C. (Breast Cancer Res. Treat. 2010)
    663. Neutrophil expression of cyclooxygenase 2 in preeclampsia. (PubMed id 20220108)1, 9 Bachawaty T....Walsh S.W. (Reprod Sci 2010)
    664. Paradoxical stimulation of cyclooxygenase-2 expression by glucocorticoids via a cyclic AMP response element in human amnion fibroblasts. (PubMed id 19797430)1, 9 Zhu X.O....Sun K. (Mol. Endocrinol. 2009)
    665. Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. (PubMed id 19268443)1, 9 Mariani F....Roncucci L. (Cancer Lett. 2009)
    666. Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis. (PubMed id 19802674)1, 9 Shimpo H....Ishiguro N. (J Orthop Sci 2009)
    667. Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. (PubMed id 19203995)1, 9 Chang K.Y....Chen B.K. (J. Biol. Chem. 2009)
    668. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. (PubMed id 18617679)1, 9 Zhao Y....Natarajan V. (Am. J. Respir. Cell Mol. Biol. 2009)
    669. R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. (PubMed id 19015962)1, 9 Eichele K....Hinz B. (Pharm. Res. 2009)
    670. Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2. (PubMed id 19723101)1, 9 Park I.J....Park O.J. (Ann. N. Y. Acad. Sci. 2009)
    671. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. (PubMed id 19638987)1, 9 Doherty G.A....Fitzgerald D.J. (Br. J. Cancer 2009)
    672. Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts. (PubMed id 19616539)1, 9 Shih C.H....Chen B.C. (Eur. J. Pharmacol. 2009)
    673. Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. (PubMed id 19639178)1, 9 Fu Y....Wang T. (Int. J. Oncol. 2009)
    674. Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. (PubMed id 20052522)1, 9 Temel S.G. and Kahveci Z. (J. Mol. Histol. 2009)
    675. Cyclooxygenase-2 expression on urothelial and inflammatory cells of cystoscopic biopsies and urine cytology as a possible predictive marker for bladder carcinoma. (PubMed id 19161536)1, 9 Moussa M....Swellam T. (APMIS 2009)
    676. The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers. (PubMed id 18720000)1, 9 Yoshinaga M....Muto Y. (Dig. Dis. Sci. 2009)
    677. COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. (PubMed id 19862936)1, 9 Ishiura Y....Myou S. (amp 2009)
    678. Cyclic stretch induces cyclooxygenase-2 gene expression in vascular endothelial cells via activation of nuclear factor kappa-beta. (PubMed id 19748489)1, 9 Zhao H....Rade J.J. (Biochem. Biophys. Res. Commun. 2009)
    679. Increased cyclooxygenase-2 expression in juvenile polyposis syndrome. (PubMed id 19124115)1, 9 van Hattem W.A....Offerhaus G.J. (Clin. Gastroenterol. Hepatol. 2009)
    680. Expression of cyclooxygenase-2 in ovarian serous carcinoma: correlation with angiogenesis, nm23 expression and survival. (PubMed id 20099494)1, 9 Ozuysal S....Evrensel T. (Eur. J. Gynaecol. Oncol. 2009)
    681. COX-2 expression is unexpectedly high in viable colorectal mucosal cells: is there life for chemoprophylaxis after VICTOR? (PubMed id 18691269)1, 9 McArthur D.R....Williams N. (Colorectal Dis 2009)
    682. Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. (PubMed id 19084589)1, 9 Jang B.C. (Toxicol In Vitro 2009)
    683. [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis]. (PubMed id 19895739)1, 9 Zhang Y.H....Li S.R. (Ai Zheng 2009)
    684. Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells. (PubMed id 19679653)1, 9 Sirianni R....Pezzi V. (J. Biol. Chem. 2009)
    685. [The effect of simultaneously blocking target epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2 on the growth of NPC cell]. (PubMed id 20120857)1, 9 Li S.S....Tian Y. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009)
    686. Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. (PubMed id 19127598)1, 9 Swami S....Feldman D. (Int. J. Cancer 2009)
    687. COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells. (PubMed id 19423863)1, 9 Salvado M.D....Redondo J.M. (Arterioscler. Thromb. Vasc. Biol. 2009)
    688. Prognostic significance of cyclooxygenase-2 overexpression in glottic cancer. (PubMed id 18172254)1, 9 Sackett M.K....TA-tu B. (Clin. Cancer Res. 2008)
    689. Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. (PubMed id 18288396)1, 9 Goto R....Mori N. (Oncol. Rep. 2008)
    690. Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium- and protein kinase C zeta-dependent. (PubMed id 18094075)1, 9 Jerde T.J....Nakada S.Y. (Mol. Pharmacol. 2008)
    691. Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation. (PubMed id 18798061)1, 9 Gu P....Cai Y. (Cancer Invest. 2008)
    692. Pro-inflammatory gene variants in myocardial infarction and longevity: implications for pharmacogenomics. (PubMed id 18991687)1, 9 ListA- F....Candore G. (Curr. Pharm. Des. 2008)
    693. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. (PubMed id 17884974)7, 9 Hinz B....Brune K. (FASEB J. 2008)
    694. Forced COX-2 expression induces PGE(2) and invasion in immortalized urothelial cells. (PubMed id 18367112)1, 9 Gee J....Sabichi A.L. (Urol. Oncol. 2008)
    695. The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. (PubMed id 18165598)1, 9 Gordon S.M....Dionne R.A. (Anesth. Analg. 2008)
    696. Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. (PubMed id 18441204)1, 9 Syeda F....Zhang H. (Am. J. Physiol. Heart Circ. Physiol. 2008)
    697. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. (PubMed id 18378414)1, 9 Erdemoglu E....Mungan T. (Maturitas 2008)
    698. Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production. (PubMed id 18297687)1, 9 Lee S.K....Lee W.J. (J. Cell. Physiol. 2008)
    699. Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice. (PubMed id 18611916)1, 9 Leung W.K....Sung J.J. (Carcinogenesis 2008)
    700. Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. (PubMed id 18817855)1, 9 Fujimori K....Urade Y. (Gene 2008)
    701. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. (PubMed id 18039779)1, 9 Banu S.K....Arosh J.A. (Endocrinology 2008)
    702. EGFR, HER-2 and COX-2 levels in colorectal cancer. (PubMed id 19102009)1, 9 Antonacopoulou A.G....Kalofonos H.P. (Histopathology 2008)
    703. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. (PubMed id 18285462)1, 9 Doller A....Eberhardt W. (Mol. Cell. Biol. 2008)
    704. Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells. (PubMed id 18097055)1, 9 Blanco A....MuA+oz-FernA!ndez M.A. (J. Immunol. 2008)
    705. Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells. (PubMed id 19116446)1, 9 Jeong K.J....Lee H.Y. (amp 2008)
    706. Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. (PubMed id 18717758)1, 9 Zhuang Z.H....Wong B.C. (J. Gastroenterol. Hepatol. 2008)
    707. Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. (PubMed id 19074839)1, 9 Zhang W....Siegfried J.M. (Mol. Cancer Res. 2008)
    708. 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. (PubMed id 18192694)1, 9 Kim E.H....Surh Y.J. (Carcinogenesis 2008)
    709. COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. (PubMed id 18462368)1, 9 McLean M.H....El-Omar E.M. (Histopathology 2008)
    710. COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. (PubMed id 18632220)1, 9 Dawsey S.P....Woodson K. (Cancer Detect. Prev. 2008)
    711. The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. (PubMed id 18571838)1, 9 Venerito M....Treiber G. (Cancer Lett. 2008)
    712. Mannan and peptidoglycan induce COX-2 protein in human PMN via the mammalian target of rapamycin. (PubMed id 17683115)1, 9 FernA!ndez N....Crespo M.S. (Eur. J. Immunol. 2007)
    713. Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells. (PubMed id 17133356)1, 9 Duggan S.V....Bartlett S.R. (J. Cell. Physiol. 2007)
    714. Global gastrointestinal safety profile of etoricoxib and lumiracoxib. (PubMed id 17691997)7, 9 Yuan Y. and Hunt R.H. (Curr. Pharm. Des. 2007)
    715. Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. (PubMed id 17128412)1, 9 Mori F....Lazzaro D. (Histol. Histopathol. 2007)
    716. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. (PubMed id 17143555)1, 9 Liagre B....Beneytout J.L. (Int. J. Mol. Med. 2007)
    717. An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. (PubMed id 17604853)1, 9 Ansorge N....Schmitz F. (Regul. Pept. 2007)
    718. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. (PubMed id 17645803)1, 9 Costa V.L....JerA^nimo C. (BMC Cancer 2007)
    719. Cyclooxygenase-2 expression in astrocytomas. Relationship with microvascular parameters, angiogenic factors expression and survival. (PubMed id 16868662)1, 9 Perdiki M....Patsouris E. (Mol. Cell. Biochem. 2007)
    720. Cardiovascular effects of the selective cyclooxygenase-2 inhibitors. (PubMed id 17612049)7, 9 White W.B. (Subcell. Biochem. 2007)
    721. Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. (PubMed id 17265445)1, 9 Denkert C....Kristiansen G. (Prostate 2007)
    722. [Effects of RNA interference of COX-2 gene expression on malignant proliferation of A549 cells in vitro]. (PubMed id 18478928)1, 9 Li W.Y....Zhang C.Y. (Zhonghua Zhong Liu Za Zhi 2007)
    723. In regard to Ishikawa et al.: Cyclooxygenase-2 impairs treatment effect of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis (Int J Radiat Oncol Biol Phys 2006;66:1347-1355). (PubMed id 17544005)1, 9 Herrera F.G....Milosevic M. (Int. J. Radiat. Oncol. Biol. Phys. 2007)
    724. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. (PubMed id 17724132)1, 9 Ghosh M....Hla T. (J. Exp. Med. 2007)
    725. Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. (PubMed id 18085997)1, 9 Skarke C....LAPtsch J. (Pharmacogenomics 2007)
    726. Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. (PubMed id 18027256)1, 9 Cho N.P....Son H.J. (Pathology 2007)
    727. Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. (PubMed id 17876541)1, 9 Mutoh H....Sugano K. (J. Gastroenterol. 2007)
    728. Pharmacodynamic of cyclooxygenase inhibitors in humans. (PubMed id 17164136)7, 9 Capone M.L....Patrignani P. (amp 2007)
    729. Cyclooxygenase-2 (COX-2) overexpression in meningiomas: real time PCR and immunohistochemistry. (PubMed id 17525632)1, 9 Buccoliero A.M....Taddei G.L. (amp 2007)
    730. Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms. (PubMed id 17707579)1, 9 Deasy B.M....O'Sullivan G.C. (Cancer Lett. 2007)
    731. Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study. (PubMed id 17457030)1, 9 Fujimi K....Iwaki T. (Dement Geriatr Cogn Disord 2007)
    732. Cyclooxygenase-2 mRNA expression correlates with aromatase expression in human breast cancer. (PubMed id 17657731)1, 9 Salhab M....Mokbel K. (J Surg Oncol 2007)
    733. Cell proliferation activity unrelated to COX-2 expression in ovarian tumors. (PubMed id 17504375)1, 9 Yoshida A....Derchain S.F. (Int. J. Gynecol. Cancer 2007)
    734. Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer. (PubMed id 17550984)1, 9 Siegfried J.M....Stabile L.P. (Mol. Pharmacol. 2007)
    735. Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. (PubMed id 17105783)1, 9 Astle S....Slater D.M. (Mol. Hum. Reprod. 2007)
    736. Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations. (PubMed id 17624243)1, 9 Pannone G....Bufo P. (Int J Immunopathol Pharmacol 2007)
    737. Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cells. (PubMed id 17405913)1, 9 Seo J.H....Kim H. (Ann. N. Y. Acad. Sci. 2007)
    738. [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas]. (PubMed id 18330256)1, 9 Li J....Pan Z. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007)
    739. Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on lung cancer: roles of cyclooxygenase-2. (PubMed id 17342342)1, 9 Uemura Y....Taguchi H. (Oncol. Rep. 2007)
    740. Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. (PubMed id 17434257)1, 9 FernA!ndez-MartA-nez A.B....Carmena M.J. (Mol. Cell. Endocrinol. 2007)
    741. Association of COX-2 expression with corresponding active and chronic inflammatory reactions in Barrett's metaplasia and progression to cancer. (PubMed id 17222248)1, 9 Ling F.C....Schneider P.M. (Histopathology 2007)
    742. Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA. (PubMed id 17016639)1, 9 Takaoka K....Urade M. (Int. J. Oncol. 2006)
    743. Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches. (PubMed id 16498361)1, 9 Brueggemeier R.W. and DA-az-Cruz E.S. (Minerva Endocrinol. 2006)
    744. RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. (PubMed id 17178865)1, 9 Chang Y.W....Jakobi R. (Cancer Res. 2006)
    745. Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. (PubMed id 16820091)1, 9 Ogino S....Fuchs C.S. (Neoplasia 2006)
    746. Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction. (PubMed id 16820795)1, 9 NA...kiaer J. (Kidney Int. 2006)
    747. Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB. (PubMed id 16212965)1, 9 GA^mez-HernA!ndez A....Egido J. (Atherosclerosis 2006)
    748. COX-2 induction by heparanase in the progression of breast cancer. (PubMed id 16391819)1, 9 Imada T....Naomoto Y. (Int. J. Mol. Med. 2006)
    749. The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. (PubMed id 16699180)1, 9 Eisinger A.L....Jones D.A. (J. Biol. Chem. 2006)
    750. Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. (PubMed id 16414978)1, 9 N'Guessan P.D....Schmeck B. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006)
    751. Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. (PubMed id 16371352)1, 9 Thiel A....RistimAoki A. (J. Biol. Chem. 2006)
    752. Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. (PubMed id 16326073)1, 9 Duque J....IA+iguez M.A. (Cell. Signal. 2006)
    753. Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. (PubMed id 16473553)1, 9 Ryan E.P....Phipps R.P. (Clin. Immunol. 2006)
    754. Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. (PubMed id 17050798)7, 9 Poggi J.C....dos Reis M.L. (J Clin Pharmacol 2006)
    755. Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. (PubMed id 16331686)1, 9 Han C....Wu T. (J. Cell. Physiol. 2006)
    756. Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. (PubMed id 17003477)1, 9 Feldon S.E....Phipps R.P. (Am. J. Pathol. 2006)
    757. Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. (PubMed id 17033106)7, 9 Brzozowski T....Pawlik W.W. (J. Physiol. Pharmacol. 2006)
    758. NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. (PubMed id 16822500)1, 9 Santhi W.S....Pillai M.R. (Exp. Mol. Pathol. 2006)
    759. Proapoptotic activity of NAG-1 is cell type specific and not related to COX-2 expression. (PubMed id 16699947)1, 9 Jang T.J....Lee C.H. (Apoptosis 2006)
    760. Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. (PubMed id 16998585)1, 9 Dixon D.A....Zimmerman G.A. (J. Clin. Invest. 2006)
    761. Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. (PubMed id 16926398)1, 9 Rydkina E....Sahni S.K. (Infect. Immun. 2006)
    762. Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts. (PubMed id 17097611)1, 9 Ogata S....Shirasuna K. (Biochem. Biophys. Res. Commun. 2006)
    763. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. (PubMed id 16681998)1, 9 Zhang W.Y....Zhu X.Z. (Biochem. Biophys. Res. Commun. 2006)
    764. Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. (PubMed id 16474375)1, 9 Milne A.N....Offerhaus G.J. (Mod. Pathol. 2006)
    765. Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. (PubMed id 16928824)1, 9 Tang H.Y....Lin H.Y. (Mol. Cancer Ther. 2006)
    766. LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. (PubMed id 16912160)1, 9 Upadhyay S....Sidransky D. (Cancer Res. 2006)
    767. Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk. (PubMed id 16808554)7, 9 Motsko S.P....Worchel J. (Drug Saf 2006)
    768. Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. (PubMed id 16682957)1, 9 Benoit V....Hainaut P. (Oncogene 2006)
    769. Endothelial cell COX-2 expression and activity in hypoxia. (PubMed id 17046322)1, 9 Cook-Johnson R.J....James M.J. (Biochim. Biophys. Acta 2006)
    770. IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. (PubMed id 15950941)1, 9 HeuzAc-Vourc'h N....Dubinett S.M. (Biochem. Biophys. Res. Commun. 2005)
    771. Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. (PubMed id 16001969)1, 9 Alvarez S....MuA+oz-FernA!ndez M. (J. Neurochem. 2005)
    772. Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells. (PubMed id 15569856)1, 9 Kohlstedt K....Fleming I. (Hypertension 2005)
    773. Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. (PubMed id 15867220)1, 9 Wang W....Damber J.E. (Clin. Cancer Res. 2005)
    774. COX-2 inhibitors and metabolism of essential fatty acids. (PubMed id 15990700)7, 9 Das U.N. (Med. Sci. Monit. 2005)
    775. Prognostic importance of COX-2 expression in patients with colorectal cancer. (PubMed id 16164044)1, 9 Yamac D....Koybasioglu F. (Pathol. Res. Pract. 2005)
    776. Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. (PubMed id 16110762)1, 9 Arnoletti J.P....Watson J.C. (amp 2005)
    777. Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. (PubMed id 16157291)1, 9 Sakurai M....Watanabe K. (Biochem. Biophys. Res. Commun. 2005)
    778. High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. (PubMed id 15817909)1, 9 Lo C.Y....Luk J.M. (Eur. J. Endocrinol. 2005)
    779. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. (PubMed id 15461587)1, 9 Clark S.R....O'Donnell V.B. (Biochem. J. 2005)
    780. Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. (PubMed id 15843495)1, 9 Ackerman W.E....Kniss D.A. (Biol. Reprod. 2005)
    781. Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. (PubMed id 16076963)1, 9 Hinz B....Brune K. (FASEB J. 2005)
    782. Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. (PubMed id 15878334)1, 9 Liou J.Y....Wu K.K. (Exp. Cell Res. 2005)
    783. Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. (PubMed id 15870920)1, 9 Yoshimoto A....Nakao S. (Oncol. Rep. 2005)
    784. Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients. (PubMed id 16097073)1, 9 Zhang J.T....Yu J. (World J. Gastroenterol. 2005)
    785. Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? (PubMed id 16190133)7, 9 Das U.N. (J Assoc Physicians India 2005)
    786. In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis. (PubMed id 15943176)7, 9 Ozgocmen S....Gudul H. (Ann. Clin. Lab. Sci. 2005)
    787. Effect of specific and non-specific inhibition of COX-2 on renal oxygenation before and after water diuresis. (PubMed id 15692221)1, 9 Gilbert S....Epstein F.H. (Nephron Physiol 2005)
    788. Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. (PubMed id 16256948)1, 9 RAPsch S....Hinz B. (Biochem. Biophys. Res. Commun. 2005)
    789. Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas. (PubMed id 15067173)1, 9 Onguru O....Lloyd R.V. (Endocr. Pathol. 2004)
    790. Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression. (PubMed id 15221958)1, 9 Han S....Roman J. (Int. J. Cancer 2004)
    791. Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta. (PubMed id 15146435)1, 9 Morgan M.P....McCarthy G.M. (Arthritis Rheum. 2004)
    792. Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. (PubMed id 15069531)1, 9 Hill K.A....Rao M.S. (Oncol. Rep. 2004)
    793. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. (PubMed id 15050918)1, 9 Crawford Y.G....Tlsty T.D. (Cancer Cell 2004)
    794. Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). (PubMed id 17516707)7, 9 Rose P. and Steinhauser C. (Clin Drug Investig 2004)
    795. Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor. (PubMed id 15838264)1, 9 Spinella F....Bagnato A. (J. Cardiovasc. Pharmacol. 2004)
    796. Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance. (PubMed id 15484698)1, 9 Buccoliero A.M....Taddei G.L. (Neuropathology 2004)
    797. The correlation between cyclooxygenase-2 expression and hepatocellular carcinogenesis. (PubMed id 15055524)1, 9 Sung Y.K....Kim M.K. (Mol. Cells 2004)
    798. Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. (PubMed id 15456329)7, 9 Hedner T....Ekbom A. (Drugs 2004)
    799. Role of cyclooxygenase-2 in colorectal cancer. (PubMed id 15000150)1, 9 Sinicrope F.A. and Gill S. (Cancer Metastasis Rev. 2004)
    800. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. (PubMed id 15319438)1, 9 Hung J.H....Lai M.D. (J. Biol. Chem. 2004)
    801. Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. (PubMed id 15481334)7, 9 Gallego-SandA-n S....Abad-Santos F. (Dig. Dis. Sci. 2004)
    802. Gastrointestinal and hepatic toxicity of selective and non-selective cyclooxygenase-2 inhibitors in pregnant and non-pregnant rats. (PubMed id 15458776)7, 9 Burdan F....Klepacz L. (Pharmacol. Res. 2004)
    803. Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. (PubMed id 14991384)1, 9 Yokota O....Kuroda S. (Acta Neuropathol. 2004)
    804. Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. (PubMed id 14984594)1, 9 Fogel-Petrovic M....Upham J.W. (Immunol. Cell Biol. 2004)
    805. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. (PubMed id 15361550)1, 9 Hinz B....Brune K. (Mol. Pharmacol. 2004)
    806. Hypoxic regulation of angiopoietin-2 expression in endothelial cells. (PubMed id 14702352)1, 9 Pichiule P....LaManna J.C. (J. Biol. Chem. 2004)
    807. Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. (PubMed id 13680221)1, 9 Shinmura K....Imakiire A. (Virchows Arch. 2004)
    808. Expression of COX-2 proteins in gastric mucosal lesions. (PubMed id 14716842)1, 9 Yu L.Z....Zhao Z.Q. (World J. Gastroenterol. 2004)
    809. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. (PubMed id 14724276)1, 9 Nagano S....Bush A.I. (J. Biol. Chem. 2004)
    810. COX-2-dependent stabilization of survivin in non-small cell lung cancer. (PubMed id 14597555)1, 9 Krysan K....Dubinett S. (FASEB J. 2004)
    811. Clinical pharmacology of novel selective COX-2 inhibitors. (PubMed id 14965322)7, 9 Tacconelli S....Patrignani P. (Curr. Pharm. Des. 2004)
    812. Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. (PubMed id 15274307)1, 9 Honjo S....Ito H. (Anticancer Res. 2004)
    813. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. (PubMed id 14729623)1, 9 Denkert C....Hauptmann S. (Cancer Res. 2004)
    814. Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. (PubMed id 15248379)1, 9 Sheehan K.M....Murray F.E. (Dig Liver Dis 2004)
    815. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. (PubMed id 14744769)1, 9 Su J.L....Kuo M.L. (Cancer Res. 2004)
    816. [Prognostic role and regulation of cyclooxygenase-2 (COX-2) in ovarian carcinoma]. (PubMed id 15478052)1, 9 Denkert C. (Zentralbl Gynakol 2004)
    817. Valdecoxib: a review. (PubMed id 12852704)7, 9 Chavez M.L. and DeKorte C.J. (Clin Ther 2003)
    818. Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. (PubMed id 12578839)1, 9 Sawaoka H....Boutaud O. (J. Biol. Chem. 2003)
    819. Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. (PubMed id 12789263)1, 9 Rosell R....Stephens C. (Oncogene 2003)
    820. Neutrophil elastase stimulates human airway epithelial cells to produce PGE2 through activation of p44/42 MAPK and upregulation of cyclooxygenase-2. (PubMed id 12832284)1, 9 Perng D.W....Lee Y.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2003)
    821. Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. (PubMed id 14669280)1, 9 Roland I.H....Xu X.X. (Cancer 2003)
    822. Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. (PubMed id 14534699)1, 9 Ferrandina G....Scambia G. (Oncol. Rep. 2003)
    823. Expression of cyclooxygenase-2 in human hyperplastic gastric polyps. (PubMed id 14582702)1, 9 Bamba H....Fujiwara K. (amp 2003)
    824. Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. (PubMed id 12852483)7, 9 Cappon G.D....Hurtt M.E. (Birth Defects Res. B Dev. Reprod. Toxicol. 2003)
    825. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. (PubMed id 12626523)1, 9 Kamei D....Kudo I. (J. Biol. Chem. 2003)
    826. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. (PubMed id 14530307)1, 9 Meyer F....Wilson K.T. (J. Immunol. 2003)
    827. Effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral TA3 supernatant on CAM from chick embryo. (PubMed id 14513718)7, 9 ZA_A+iga J....Lemus D. (Biol. Res. 2003)
    828. Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. (PubMed id 12784332)1, 9 Denkert C....Hauptmann S. (Cancer 2003)
    829. Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. (PubMed id 12534640)7, 9 Kirchheiner J....BrockmAPller J. (Br J Clin Pharmacol 2003)
    830. PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells. (PubMed id 12800228)1, 9 Li M.Y....Tan X.Y. (World J. Gastroenterol. 2003)
    831. Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. (PubMed id 12782823)1, 9 Sung M.W....Kim K.H. (Laryngoscope 2003)
    832. Cyclo-oxygenase-2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans. (PubMed id 12813143)1, 9 Langberg H....Kjaer M. (J. Physiol. (Lond.) 2003)
    833. Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. (PubMed id 14517215)1, 9 Bradbury D.A....Knox A.J. (J. Biol. Chem. 2003)
    834. Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor. (PubMed id 12824918)7, 9 Chen W.S....Yang W.K. (Cancer Sci. 2003)
    835. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. (PubMed id 12573452)7, 9 Ait-Said F....Hatmi M. (Biochim. Biophys. Acta 2003)
    836. [Pharmacology of cyclooxygenase 2 inhibition]. (PubMed id 12705061)7, 9 Beubler E. (Wien Med Wochenschr 2003)
    837. Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. (PubMed id 12401798)1, 9 Liu X.H....Levine A.C. (J. Biol. Chem. 2002)
    838. Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. (PubMed id 12450219)1, 9 Xiang Z....Pasinetti G.M. (Gene Expr. 2002)
    839. Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production. (PubMed id 12145315)1, 9 Han R. and Smith T.J. (J. Biol. Chem. 2002)
    840. Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. (PubMed id 12444028)1, 9 Yang X....Morrell N.W. (Am. J. Respir. Cell Mol. Biol. 2002)
    841. 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). (PubMed id 11906292)1, 9 Hashimoto H....Wakitani K. (J. Med. Chem. 2002)
    842. Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. (PubMed id 12050157)1, 9 Bazan N.G. and Lukiw W.J. (J. Biol. Chem. 2002)
    843. Cyclooxygenase-2 expression by transcription factors in Helicobacter pylori-infected gastric epithelial cells: comparison between HP 99 and NCTC 11637. (PubMed id 12485915)1, 9 Seo J.H....Kim K.H. (Ann. N. Y. Acad. Sci. 2002)
    844. Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. (PubMed id 11897504)1, 9 Richards J.A....Brueggemeier R.W. (J. Steroid Biochem. Mol. Biol. 2002)
    845. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. (PubMed id 11847219)1, 9 Han R....Smith T.J. (J. Biol. Chem. 2002)
    846. Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. (PubMed id 12391278)1, 9 Wort S.J....Mitchell J.A. (Mol. Pharmacol. 2002)
    847. Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells. (PubMed id 12205039)1, 9 Pang L....Knox A.J. (FASEB J. 2002)
    848. Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. (PubMed id 12664576)1, 9 Hsi L.C....Eling T.E. (Adv. Exp. Med. Biol. 2002)
    849. Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. (PubMed id 12208114)7, 9 Cipolla G....Frigo G. (Pharmacol. Res. 2002)
    850. Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. (PubMed id 12405290)1, 9 Konno H....Nakamura S. (amp 2002)
    851. The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity. (PubMed id 12564662)7, 9 Tacconelli S....Patrignani P. (Curr Med Res Opin 2002)
    852. Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders. (PubMed id 12397176)1, 9 Frungieri M.B....Mayerhofer A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    853. Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. (PubMed id 12209724)1, 9 Ferrandina G....Lauriola L. (Cancer 2002)
    854. Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. (PubMed id 11891188)1, 9 Denkert C....Hauptmann S. (Am. J. Pathol. 2002)
    855. Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a pharmacologist's perspective. (PubMed id 11695253)7, 9 Brune K. and Neubert A. (Clin. Exp. Rheumatol. 2001)
    856. Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. (PubMed id 11705852)1, 9 Bing R.J....Shi S.R. (Clin. Cancer Res. 2001)
    857. Rofecoxib: a review of its use in the management of osteoarthritis, acute pain and rheumatoid arthritis. (PubMed id 11398914)7, 9 Matheson A.J. and Figgitt D.P. (Drugs 2001)
    858. Aromatase and COX-2 expression in human breast cancers. (PubMed id 11850206)1, 9 Brodie A.M....Thijssen J.H. (J. Steroid Biochem. Mol. Biol. 2001)
    859. Evaluation of intravenous parecoxib for the relief of acute post-surgical pain. (PubMed id 11060833)7, 9 Jain K.K. (Expert Opin Investig Drugs 2000)
    860. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. (PubMed id 10715145)7, 9 Talley J.J....Seibert K. (J. Med. Chem. 2000)
    861. A comparison of the effects of etodolac and ibuprofen on renal haemodynamics, tubular function, renin, vasopressin and urinary excretion of albumin and alpha-glutathione-S-transferase in healthy subjects: a placebo-controlled cross-over study. (PubMed id 11009046)7, 9 Svendsen K.B....Pedersen E.B. (Eur. J. Clin. Pharmacol. 2000)
    862. Renal damage induced by the treatment with non-opioid analgesics--theoretical assumption or clinical significance. (PubMed id 11153163)7, 9 Fackovcova D....Kriska M. (Bratisl Lek Listy 2000)
    863. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. (PubMed id 11118042)7, 9 Taylor M.T....Gerner E.W. (Cancer Res. 2000)
    864. Germline alterations in the cyclooxygenase-2 gene are not associated with the development of extracolonic manifestations in a large swiss familial adenomatous polyposis kindred. (PubMed id 10956391)4, 9 Humar B....Dobbie Z. (Int. J. Cancer 2000)
    865. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. (PubMed id 10485483)7, 9 Molina M.A....Sinicrope F.A. (Cancer Res. 1999)
    866. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. (PubMed id 10450786)7, 9 Berg J....Stimmeder D. (Inflamm. Res. 1999)
    867. Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. (PubMed id 10372826)7, 9 Giuliano F. and Warner T.D. (Br. J. Pharmacol. 1999)
    868. Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. (PubMed id 10594327)7, 9 Kusuhara H....Sugahara K. (Eur. J. Pharmacol. 1999)
    869. [New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase]. (PubMed id 9711054)7, 9 Stichtenoth D.O....FrAPlich J.C. (Med. Klin. (Munich) 1998)
    870. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. (PubMed id 9626023)7, 9 Cryer B. and Feldman M. (Am. J. Med. 1998)
    871. Budesonide epimer R or dexamethasone selectively inhibit platelet- activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. (PubMed id 9520467)1, 9 Lukiw W.J.... Bazan N.G. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    872. Cyclooxygenase selectivity and the risk of gastro-intestinal complications of various non-steroidal anti-inflammatory drugs: a clinical consideration. (PubMed id 9831331)7, 9 Kawai S. (Inflamm. Res. 1998)
    873. Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. (PubMed id 9253954)7, 9 Capasso A. and Sorrentino L. (Eur. J. Pharmacol. 1997)
    874. Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression. (PubMed id 23922175)1 Wu C.T....Liu H.H. (Tumour Biol. 2014)
    875. Significance of COX-2 and VEGF expression in histopathologic grading and invasiveness of meningiomas. (PubMed id 23756256)1 Lee S.H....Kang C.S. (APMIS 2014)
    876. Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. (PubMed id 24184161)1 Hua K.T....Chien M.H. (Biochim. Biophys. Acta 2014)
    877. Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis. (PubMed id 24186266)1 Lau A....Brown T.J. (Exp. Biol. Med. (Maywood) 2014)
    878. NF-I_B and COX-2 expression in nonmalignant endometrial lesions and cancer. (PubMed id 24436266)1 Faloppa C.C....Soares F.A. (Am. J. Clin. Pathol. 2014)
    879. Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. (PubMed id 24064301)1 VAPlzke A....Pfeilschifter J. (Biochim. Biophys. Acta 2014)
    880. Molecular markers of therapeutic resistance in breast cancer. (PubMed id 23434145)1 Zhou L....Huang Q. (Hum. Pathol. 2013)
    881. Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. (PubMed id 24089527)1 Chen S.F....Shyue S.K. (J. Biol. Chem. 2013)
    882. Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy. (PubMed id 23449721)1 Matthaei M....Jun A.S. (amp 2013)
    883. Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma. (PubMed id 23809761)1 Kono M....Chikazu D. (J. Oral Maxillofac. Surg. 2013)
    884. Cox-2 gene variants in migraine. (PubMed id 23357220)1 Dasdemir S....Cakmakoglu B. (Gene 2013)
    885. COX-2 and PPAR-I^ confer cannabidiol-induced apoptosis of human lung cancer cells. (PubMed id 23220503)1 Ramer R....Hinz B. (Mol. Cancer Ther. 2013)
    886. Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population. (PubMed id 23765972)1 Yi X.Y....Chi W.Z. (Genet. Mol. Res. 2013)
    887. Significance of cyclooxygenase 2, EZH-2 polycomb group and p53 expression in actinic keratosis and squamous cell carcinomas of the skin. (PubMed id 23095338)1 Athanassiadou A.M....Aroni K. (Am J Dermatopathol 2013)
    888. TNFI+-activated stromal COX-2 signalling promotes proliferative and invasive potential of colon cancer epithelial cells. (PubMed id 23869759)1 Zhu M....Lance P. (Cell Prolif. 2013)
    889. Cyclooxygenase-2, epidermal growth factor receptor, and aromatase signaling in inflammation and mesothelioma. (PubMed id 23729401)1 Nuvoli B. and Galati R. (Mol. Cancer Ther. 2013)
    890. Effects of ectopic HER-2/neu gene expression on the COX-2/PGE2/P450arom signaling pathway in endometrial carcinoma cells: HER-2/neu gene expression in endometrial carcinoma cells. (PubMed id 23453006)1 Li S....Yu Z. (amp 2013)
    891. Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells. (PubMed id 24115825)1 Liu X.J....Qiao L. (World J. Gastroenterol. 2013)
    892. A9-Catenin, Cox-2 and p53 immunostaining in colorectal adenomas to predict recurrence after endoscopic polypectomy. (PubMed id 23516071)1 Brand L....Tannapfel A. (Int J Colorectal Dis 2013)
    893. Interrelationship and expression profiling of cyclooxygenase and angiogenic factors in Indian patients with multiple myeloma. (PubMed id 22971811)1 Khan R....Sharma A. (Ann. Hematol. 2013)
    894. The association between COX-2 polymorphisms and hematologic toxicity in patients with advanced non-small-cell lung cancer treated with platinum-based chemotherapy. (PubMed id 23620771)1 Zhou F....Zhou C. (PLoS ONE 2013)
    895. Lung inflammation caused by adenosine-5'-triphosphate is mediated via Ca2+/PKCs-dependent COX-2/PGE2 induction. (PubMed id 23680674)1 Lee I.T....Yang C.M. (amp 2013)
    896. Structural modeling and simulation studies of human cyclooxygenase (COX) isozymes with selected terpenes: implications in drug designing and development. (PubMed id 23668350)1 Singh S....Dwivedi U.N. (Comput. Biol. Med. 2013)
    897. Effects of PGF2I+ on the expression of uterine activation proteins in pregnant human myometrial cells from upper and lower segment. (PubMed id 23678036)1 Xu C....Olson D.M. (J. Clin. Endocrinol. Metab. 2013)
    898. Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis. (PubMed id 23857285)1 Jiao G....Guo W. (Tumour Biol. 2013)
    899. AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/I^-catenin signaling pathway. (PubMed id 23645839)1 Zhang Y....Yeh J.R. (Blood 2013)
    900. Cyclooxygenase-2 polymorphisms were associated with the risk of gastric cancer: evidence from a meta-analysis based on case-control studies. (PubMed id 23775011)1 Yan W.F....Wu G. (Tumour Biol. 2013)
    901. COX-2, TFF1, and Src define better prognosis in young patients with gastric cancer. (PubMed id 24037722)1 Schildberg C....Allgayer H. (J Surg Oncol 2013)
    902. Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4, and ROS-dependent COX-2-derived prostanoids. (PubMed id 23232839)1 Wong W.T....Huang Y. (J. Cardiovasc. Pharmacol. 2013)
    903. Cyclooxygenase-2 expression and clinical parameters in laryngeal squamous cell carcinoma, vocal fold nodule, and laryngeal atypical hyperplasia. (PubMed id 22247036)1 Sayar C....Kemal Olgun M. (amp 2013)
    904. [Evaluation of COX-2 protein expression in melanocytic nevi in children]. (PubMed id 24052986)1 Kubus M....Taran K. (Pol. Merkur. Lekarski 2013)
    905. The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells. (PubMed id 23254909)1 Lai Y....Feng Y. (Int. J. Oncol. 2013)
    906. Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival. (PubMed id 23446663)1 Parente R....Di Renzo L. (Oncol. Rep. 2013)
    907. The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients. (PubMed id 23219238)1 Nadalin S....BuretiA8-TomljanoviA8 A. (Prostaglandins Leukot. Essent. Fatty Acids 2013)
    908. Eicosanoid modulation by the short-chain fatty acid n-butyrate in human monocytes. (PubMed id 23398566)1 Kovarik J.J....Zlabinger G.J. (Immunology 2013)
    909. Platelet response to aspirin in Chinese stroke patients is independent of genetic polymorphisms of COX-1 C50T and COX-2 G765C. (PubMed id 22972377)1 Yi X....Han Z. (J. Atheroscler. Thromb. 2013)
    910. MMP1, MMP9, and COX2 expressions in promonocytes are induced by breast cancer cells and correlate with collagen degradation, transformation-like morphological changes in MCF-10A acini, and tumor aggressiveness. (PubMed id 23762835)1 Chimal-RamA-rez G.K....Fuentes-PananA! E.M. (Biomed Res Int 2013)
    911. Endothelial dysfunction in small arteries of essential hypertensive patients: role of cyclooxygenase-2 in oxidative stress generation. (PubMed id 23734008)1 Virdis A....Taddei S. (Hypertension 2013)
    912. Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology. (PubMed id 23873111)1 Jarzabek K....Wolczynski S. (Tumour Biol. 2013)
    913. COX-2 overexpression Induced by gene transfer reduces sensitivity of TE13 esophageal carcinoma cells to 5-fluorouracil and cisplatin. (PubMed id 23393346)1 Okamura H....Otsuji E. (Anticancer Res. 2013)
    914. COX-2 promotes breast cancer cell radioresistance via p38/MAPK-mediated cellular anti-apoptosis and invasiveness. (PubMed id 23771849)1 Lin F....Yang G. (Tumour Biol. 2013)
    915. Mycoplasma fermentans MALP-2 induces heme oxygenase-1 expression via mitogen-activated protein kinases and Nrf2 pathways to modulate cyclooxygenase 2 expression in human monocytes. (PubMed id 23536693)1 Ma X....Wu Y. (Clin. Vaccine Immunol. 2013)
    916. The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. (PubMed id 23261444)1 Shimokawa M....Ozawa M. (Biochem. Biophys. Res. Commun. 2013)
    917. ATP mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation. (PubMed id 23326583)1 Cheng S.E....Yang C.M. (PLoS ONE 2013)
    918. Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells. (PubMed id 23973990)1 Iachininoto M.G....Rutella S. (Molecules 2013)
    919. [Mechanisms of EGF regulation of COX-2 through the STAT5 signaling pathway in human lung adenocarcinoma A549 cells]. (PubMed id 23601296)1 Cao S....Cui J. (Zhongguo Fei Ai Za Zhi 2013)
    920. Intravenous immunoglobulin expands regulatory T cells via induction of cyclooxygenase-2-dependent prostaglandin E2 in human dendritic cells. (PubMed id 23847198)1 Trinath J....Bayry J. (Blood 2013)
    921. Prognostic significance of cyclooxygenase-2 in cervical cancer: a meta-analysis. (PubMed id 22729746)1 Huang M....Zhao X. (Int. J. Cancer 2013)
    922. Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells. (PubMed id 23233037)1 Nunes C....Laranjinha J. (amp 2013)
    923. Cyclooxygenase-2 over-expression inhibits liver apoptosis induced by hyperglycemia. (PubMed id 23059845)1 FrancAcs D.E....Carnovale C.E. (J. Cell. Biochem. 2013)
    924. The effects of oral and enteric Campylobacter concisus strains on expression of TLR4, MD-2, TLR2, TLR5 and COX-2 in HT-29 cells. (PubMed id 23437263)1 Ismail Y....Zhang L. (PLoS ONE 2013)
    925. Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. (PubMed id 23564449)1 Gao R....Wadhwa R. (J. Biol. Chem. 2013)
    926. Eicosanoid profiling in colon cancer: emergence of a pattern. (PubMed id 22960430)1 Zuo X. and Shureiqi I. (amp 2013)
    927. Prognostic significance of COX-2 expression and correlation with Bcl-2 and VEGF expression, microvessel density, and clinical variables in classical Hodgkin lymphoma. (PubMed id 23851330)1 Koh Y.W....Huh J. (Am. J. Surg. Pathol. 2013)
    928. Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. (PubMed id 23179791)1 Serna-Marquez N....Salazar E.P. (Cell Oncol (Dordr) 2013)
    929. Association of COX-2 rs20417 with aspirin resistance. (PubMed id 22763923)1 Sharma V....Munshi A. (J. Thromb. Thrombolysis 2013)
    930. COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: a quantitative immunohistochemical analysis of RTOG C0128. (PubMed id 23221733)1 Doll C.M....Magliocco A.M. (Int. J. Gynecol. Cancer 2013)
    931. Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer. (PubMed id 23629521)1 Yamauchi M....Ogino S. (amp 2013)
    932. Cyclooxygenase-2 generates the endogenous mutagen trans-4-hydroxy-2-nonenal in Enterococcus faecalis-infected macrophages. (PubMed id 23321929)1 Wang X....Huycke M.M. (Cancer Prev Res (Phila) 2013)
    933. Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation. (PubMed id 23536473)1 Sha W....BrA1ne B. (Int. J. Cancer 2013)
    934. High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. (PubMed id 23360427)1 Tong X....Huang Y. (Cardiovasc Diabetol 2013)
    935. Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer. (PubMed id 24344016)1 Li T....Zhong Y. (J BUON 2013)
    936. The association between cyclooxygenase-2 1195A G/A polymorphism and hepatocellular carcinoma: evidence from a meta-analysis. (PubMed id 23494177)1 Bu X. and Zhao C. (Tumour Biol. 2013)
    937. Association between a functional variant at PTGS2 gene 3'UTR and its mRNA expression in lymphoblastoid cell lines. (PubMed id 23444045)1 Wang X....Guan X. (Cell Biol. Int. 2013)
    938. Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents. (PubMed id 23435965)1 Bertrand J....Leger D.Y. (Apoptosis 2013)
    939. Corticotropin-releasing hormone interacts with interleukin-1I^ to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor. (PubMed id 23666959)1 Markovic D....Grammatopoulos D.K. (J. Clin. Endocrinol. Metab. 2013)
    940. Endothelin-1 enhances cell migration through COX-2 up-regulation in human chondrosarcoma. (PubMed id 23523690)1 Wu M.H....Tang C.H. (Biochim. Biophys. Acta 2013)
    941. Expression of estrogen receptors (I+, I^), cyclooxygenase-2 and aromatase in normal endometrium and endometrioid cancer of uterus. (PubMed id 23625281)1 Knapp P....Knapp P.A. (Adv Med Sci 2013)
    942. Increased expression of sphingosine kinase in the amnion during labor. (PubMed id 23462226)1 Erkhembaatar L.O....Kikkawa F. (Placenta 2013)
    943. Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells. (PubMed id 22718198)1 Chuang C.W....Hung W.C. (J. Cell. Physiol. 2013)
    944. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. (PubMed id 23613363)1 Manferdini C....Lisignoli G. (Arthritis Rheum. 2013)
    945. Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms. (PubMed id 23633486)1 Mao Y....Kiessling R. (Cancer Res. 2013)
    946. Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol. (PubMed id 23495037)1 Lin H.Y....Wu J.M. (J. Cell. Biochem. 2013)
    947. The Notch1/cyclooxygenase-2/Snail/E-cadherin pathway is associated with hypoxia-induced hepatocellular carcinoma cell invasion and migration. (PubMed id 23124652)1 Yu L.X....Zhang S.G. (Oncol. Rep. 2013)
    948. Relationship between serum levels of triglycerides and vascular inflammation, measured as COX-2, in arteries from diabetic patients: a translational study. (PubMed id 23642086)1 Gordillo-Moscoso A....Redondo S. (Lipids Health Dis 2013)
    949. Association between the 8473T&gt;C polymorphism of PTGS2 and prostate cancer risk: a metaanalysis including 24,716 subjects. (PubMed id 23548966)1 Yang X....Guo Z. (Onkologie 2013)
    950. High expression of cyclooxygenase-2 in uterine fibroids and its correlation with cell proliferation. (PubMed id 23398724)1 Ke X....Zuo X. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2013)
    951. Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer. (PubMed id 23955344)1 Dong L....Smith W.L. (J. Biol. Chem. 2013)
    952. Influence of Cyclooxygenase-2 (COX-2) gene promoter-1195 and allograft inflammatory factor-1 (AIF-1) polymorphisms on allograft outcome in Hispanic kidney transplant recipients. (PubMed id 23777936)1 Vu D....Min D.I. (Hum. Immunol. 2013)
    953. Seminal plasma induces prostaglandin-endoperoxide synthase (PTGS) 2 expression in immortalized human vaginal cells: involvement of semen prostaglandin E2 in PTGS2 upregulation. (PubMed id 23153564)1 Joseph T....Doncel G.F. (Biol. Reprod. 2013)
    954. miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells. (PubMed id 23973710)1 Pham H....Eibl G. (Biochem. Biophys. Res. Commun. 2013)
    955. Association study of polymorphisms in the cyclooxygenase-2 gene and Alzheimer's disease risk in Chinese. (PubMed id 22622868)1 Tang W....Zhang L. (Neurol. Sci. 2013)
    956. Prognostic significance of COX-2 immunohistochemical expression in colorectal cancer: a meta-analysis of the literature. (PubMed id 23527044)1 Peng L....Zhao Q. (PLoS ONE 2013)
    957. Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily. (PubMed id 23431194)1 Sjogren T.... Geschwindner S. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    958. High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer. (PubMed id 23898071)1 Elzagheid A....PyrhAPnen S. (Anticancer Res. 2013)
    959. PI3K mediates stretch-induced COX-2 expression during urinary tract obstruction. (PubMed id 22998445)1 Owusu-Ofori K....Nakada S.Y. (J. Endourol. 2013)
    960. Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells. (PubMed id 23376640)1 Xu W....Sun W.H. (Cancer Lett. 2013)
    961. Cyclooxygenase-2 expression in lung in patients with congenital heart malformations and pulmonary arterial hypertension. (PubMed id 23681850)1 Loukanov T....Gorenflo M. (Thorac Cardiovasc Surg 2013)
    962. Androgen receptor promotes the migration and invasion of upper urinary tract urothelial carcinoma cells through the upregulation of MMP-9 and COX-2. (PubMed id 23715826)1 Chen C.C....Shyr C.R. (Oncol. Rep. 2013)
    963. Stretch magnitude- and frequency-dependent cyclooxygenase 2 and prostaglandin E2 up-regulation in human endometrial stromal cells: possible implications in endometriosis. (PubMed id 23239446)1 Li X....Fan Y. (Exp. Biol. Med. (Maywood) 2012)
    964. Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? (PubMed id 23520664)1 Jana D....Ganguly S. (J Indian Med Assoc 2012)
    965. Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis. (PubMed id 23028744)1 Czachorowski M.J....Malats N. (PLoS ONE 2012)
    966. Increased expression of IL-6 family members in tendon pathology. (PubMed id 22337942)1 Legerlotz K....Riley G.P. (Rheumatology (Oxford) 2012)
    967. Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid. (PubMed id 22942274)1 Musee J. and Marnett L.J. (J. Biol. Chem. 2012)
    968. COX-2 in the neurodegenerative process of Parkinson's disease. (PubMed id 22826171)1 Teismann P. (Biofactors 2012)
    969. A seven-marker signature and clinical outcome in malignant melanoma: a large-scale tissue-microarray study with two independent patient cohorts. (PubMed id 22685558)1 Meyer S....Wild P.J. (PLoS ONE 2012)
    970. Interplay between membrane lipid peroxidation, transglutaminase activity, and cyclooxygenase 2 expression in the tissue adjoining to breast cancer. (PubMed id 21678409)1 Balestrieri M.L....Stiuso P. (J. Cell. Physiol. 2012)
    971. The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. (PubMed id 22049153)1 Young L.E....Dixon D.A. (Mol. Cancer Res. 2012)
    972. Systematic review and meta-analysis of COX-2 expression and polymorphisms in prostate cancer. (PubMed id 23053989)1 Shao N....Hua L. (Mol. Biol. Rep. 2012)
    973. Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation. (PubMed id 23144866)1 Garufi A....D'Orazi G. (PLoS ONE 2012)
    974. Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases. (PubMed id 22371637)1 Almeida P.R....Ribeiro R.A. (World J. Gastroenterol. 2012)
    975. Promoter methylation regulates cigarette smoke-stimulated cyclooxygenase-2 expression in esophageal squamous cell carcinoma. (PubMed id 22435505)1 Meng X.Y....Zhang S.T. (J Dig Dis 2012)
    976. [Small interfering RNA in silencing cox-2 expression enhances radiosensitivity of esophageal cancer EC9706 cell]. (PubMed id 22944132)1 Wu H....Fan Q.X. (Zhonghua Yi Xue Za Zhi 2012)
    977. Correlation of prostaglandin metabolizing enzymes and serum PGE2 levels with vitamin D receptor and serum 25(OH)2D3 levels in breast and ovarian cancer. (PubMed id 22213326)1 Cordes T....Thill M. (Anticancer Res. 2012)
    978. Cyclooxygenase-2 -765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population. (PubMed id 21800055)1 He J....He W. (Mol. Biol. Rep. 2012)
    979. The expression of MAGE and SSX, and correlation of COX2, VEGF, and survivin in colorectal cancer. (PubMed id 22287745)1 Choi J. and Chang H. (Anticancer Res. 2012)
    980. The effects of cyclooxygenase-2 gene silencing by siRNA on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan-2 human pancreatic cancer cells. (PubMed id 22200969)1 Zhong Y....Zan H. (Oncol. Rep. 2012)
    981. The influence of transforming growth factor-I+, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer. (PubMed id 22582975)1 Fanelli M.F....Montagnini A.L. (Histopathology 2012)
    982. COX2 overexpression is a prognostic marker for Stage III breast cancer. (PubMed id 21533532)1 Kim H.S....Noh D.Y. (Breast Cancer Res. Treat. 2012)
    983. A novel cytotoxic T lymphocyte epitope analogue with enhanced activity derived from cyclooxygenase-2. (PubMed id 22686557)1 Wu Y.H....Qi Y.M. (Scand. J. Immunol. 2012)
    984. Expression of COX-2 on Reed-Sternberg cells is an independent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD. (PubMed id 22547578)1 Mestre F....Rodriguez J. (Blood 2012)
    985. Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development. (PubMed id 22376259)1 Kwagyan J....Ashktorab H. (Clin Transl Sci 2012)
    986. Expression of cyclooxygenase-2 (COX-2) in pituitary tumours. (PubMed id 22460097)1 SokoA8owski G....GoA8kowski F. (Med. Sci. Monit. 2012)
    987. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. (PubMed id 22819245)1 Li G....Chow L.W. (Cytokine 2012)
    988. A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation. (PubMed id 21822307)1 Moore A.E....Dixon D.A. (Oncogene 2012)
    989. Association of cyclooxygenase 2 single-nucleotide polymorphisms and hepatocellular carcinoma in Taiwan. (PubMed id 22242948)1 Chang W.S....Bau D.T. (Chin J Physiol 2012)
    990. The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. (PubMed id 22331023)1 GaA8ecki P....Szemraj J. (J Affect Disord 2012)
    991. Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells. (PubMed id 23226427)1 Agra Andrieu N....MartA-n-Sanz P. (PLoS ONE 2012)
    992. Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells. (PubMed id 22885178)1 Zhu Y....Lance P. (Biochem. Biophys. Res. Commun. 2012)
    993. Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. (PubMed id 23105117)1 VA!zquez-Cedeira M. and Lazo P.A. (J. Biol. Chem. 2012)
    994. Effects of Feiyanning Decoction, a compound traditional Chinese medicine, on iNOS and COX-2 expressions induced by tumor necrosis factor-I+ in lung adenocarcinoma cell line. (PubMed id 22704420)1 Wang J.Y....Wang Q. (Zhong Xi Yi Jie He Xue Bao 2012)
    995. PTGS2 (COX2)A -765G&gt;C gene polymorphism and risk of sporadic colorectal cancer in Iranian population. (PubMed id 22173719)1 Daraei A....Mohamadhashem F. (Mol. Biol. Rep. 2012)
    996. Lower cyclooxygenase-2 expression is associated with recurrence of solitary non-muscle invasive bladder carcinoma. (PubMed id 23126361)1 Tadin T....JonjiA8 N. (Diagn Pathol 2012)
    997. Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-I_B activation in TPA-induced breast cancer cells. (PubMed id 22740037)1 Park S.Y....Lee S.J. (J. Cell. Biochem. 2012)
    998. Heterogeneity of COX-2 and multidrug resistance between primary tumors and regional lymph node metastases of gastric cancer. (PubMed id 23052170)1 Li Y....Wang D. (Tumori 2012)
    999. Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia. (PubMed id 22397921)1 Tang B....Thomas E.A. (Psychiatry Res 2012)
    1000. The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target. (PubMed id 22808264)1 Orlando U.D....PodestA! E.J. (PLoS ONE 2012)
    1001. Cyclooxygenase-2 (COX-2) up-regulation is a prognostic marker for poor clinical outcome of upper tract urothelial cancer. (PubMed id 22993369)1 Ke H.L....Bau D.T. (Anticancer Res. 2012)
    1002. Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis. (PubMed id 22435969)1 Zhang H....Ma B. (BMC Immunol. 2012)
    1003. Cyclooxygenase-2 -765G&gt;C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstructive pulmonary disease patients. (PubMed id 22100366)1 LA^pez-Campos J.L....Arellano E. (amp 2012)
    1004. Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features. (PubMed id 22037828)1 Festa-Vasconcellos J.S....Vianna-Jorge R. (Breast Cancer Res. Treat. 2012)
    1005. CFTR negatively regulates cyclooxygenase-2-PGE(2) positive feedback loop in inflammation. (PubMed id 21913191)1 Chen J....Chan H.C. (J. Cell. Physiol. 2012)
    1006. Effects of estrogen on endothelial prostanoid production and cyclooxygenase-2 and heme oxygenase-1 expression. (PubMed id 22330859)1 Marcantoni E....Patrignani P. (amp 2012)
    1007. Synergistic association of PTGS2 and CYP2E1 genetic polymorphisms with lung cancer risk in northeastern Chinese. (PubMed id 22761909)1 Guo S....Niu W. (PLoS ONE 2012)
    1008. The DHEA metabolite 7I^-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. (PubMed id 22342541)1 Sandra N....Olivier H. (Steroids 2012)
    1009. Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes. (PubMed id 22286316)1 Park B.W....Lee K.S. (Breast Cancer Res. Treat. 2012)
    1010. Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. -765G&gt;C PTGS2 polymorphism and NMSC risk. (PubMed id 22159575)1 CocoA9 R....Raicu F. (Arch. Dermatol. Res. 2012)
    1011. Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact. (PubMed id 22936450)1 Dhakal H.P....Nesland J.M. (Histol. Histopathol. 2012)
    1012. Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells. (PubMed id 21854542)1 Chen L....Johnson M.R. (J. Cell. Mol. Med. 2012)
    1013. Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. (PubMed id 22335196)1 Wang J....Deng W. (J. Pineal Res. 2012)
    1014. Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner. (PubMed id 22626465)1 Terazawa S....Imokawa G. (Exp. Dermatol. 2012)
    1015. Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. (PubMed id 22735610)1 Morita Y....Yoneda T. (Int. J. Oncol. 2012)
    1016. Acyl chain-dependent effect of lysophosphatidylcholine on cyclooxygenase (COX)-2 expression in endothelial cells. (PubMed id 22901457)1 BrkiA8 L....Frank S. (Atherosclerosis 2012)
    1017. DNA hypomethylation of the COX-2 gene promoter is associated with up-regulation of its mRNA expression in eutopic endometrium of endometriosis. (PubMed id 22608095)1 Wang D....Li T. (Eur. J. Med. Res. 2012)
    1018. AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells. (PubMed id 22330070)1 Lee J.Y....Kang I. (Cell. Signal. 2012)
    1019. siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis. (PubMed id 22506937)1 Kim J.Y....Oh S.H. (Exp. Dermatol. 2012)
    1020. Correlation between spiral CT preoperative staging of pancreatic cancer and PTEN and COX-2 expression. (PubMed id 22389271)1 Chun-Ye Q....Ming G. (Hepatogastroenterology 2012)
    1021. Cytoskeletal architecture regulates cyclooxygenase-2 in human endothelial cells: autocrine modulation by prostacyclin. (PubMed id 22495438)1 Eligini S....Colli S. (J. Cell. Physiol. 2012)
    1022. Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C. (PubMed id 22863264)1 Miyashita M....Imawari M. (J. Viral Hepat. 2012)
    1023. Involvement of COX-2/PGE2 signalling in hypoxia-induced angiogenic response in endothelial cells. (PubMed id 22050691)1 Zhao L....Wei X. (J. Cell. Mol. Med. 2012)
    1024. Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid. (PubMed id 21681438)1 Graham V.S....Botham K.M. (Eur J Nutr 2012)
    1025. Regulation of IL-1I^-induced cyclooxygenase-2 expression by interactions of AI^ peptide, apolipoprotein E and nitric oxide in human neuroglioma. (PubMed id 22101739)1 Samy A.S. and Igwe O.J. (J. Mol. Neurosci. 2012)
    1026. Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women. (PubMed id 22587873)1 Kim H.Y....Lee B.S. (Am. J. Reprod. Immunol. 2012)
    1027. Cyclooxygenase-2 expression in central giant cell lesion of the jaws: an immunohistochemical study. (PubMed id 22042094)1 Nogueira R.L....Rabenhorst S.H. (J. Mol. Histol. 2012)
    1028. Inhibition of cyclooxygenase-2 and inducible nitric oxide synthase by silymarin in proliferating mesenchymal stem cells: comparison with glutathione modifiers. (PubMed id 21710354)1 Ahmadi-Ashtiani H....Barkhordari E. (J Nat Med 2012)
    1029. Expression levels of cyclooxygenase-2, tumor necrosis factor-I+ and inducible NO synthase in placental tissue of normal and preeclamptic pregnancies. (PubMed id 22014124)1 Goksu Erol A.Y....Yildiz S.E. (amp 2012)
    1030. Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2I+. (PubMed id 22982857)1 Tsikas D....Stichtenoth D.O. (FEBS Lett. 2012)
    1031. Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. (PubMed id 22668799)7 Palayoor S.T....Coleman C.N. (J. Cardiovasc. Pharmacol. 2012)
    1032. A randomized phase II of gemcitabine and sorafenib versus sorafenib alone in patients with metastatic pancreatic cancer. (PubMed id 21424698)1 El-Khoueiry A.B....Lenz H.J. (Invest New Drugs 2012)
    1033. Maximal standardized uptake value on FDG-PET is correlated with cyclooxygenase-2 expression in patients with lung adenocarcinoma. (PubMed id 22206958)1 Shimizu K....Nakata M. (Ann. Thorac. Surg. 2012)
    1034. Anti-inflammatory potential of an ethyl acetate fraction isolated from Justicia gendarussa roots through inhibition of iNOS and COX-2 expression via NF-I_B pathway. (PubMed id 22063737)1 Kumar K.S....Helen A. (Cell. Immunol. 2012)
    1035. Notch2-induced COX-2 expression enhancing gastric cancer progression. (PubMed id 21976141)1 Tseng Y.C....Yeh T.S. (Mol. Carcinog. 2012)
    1036. Expression of ezrin, MMP-9, and COX-2 in 50 chordoma specimens: a clinical and immunohistochemical analysis. (PubMed id 22228328)1 Froehlich E.V....Leithner A. (Spine 2012)
    1037. miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. (PubMed id 22406049)1 Chen L....Jiang C. (Eur. J. Cancer 2012)
    1038. -765 Ga89C and -1195 Aa89G promoter variants of the cyclooxygenase-2 gene decrease the risk for preeclampsia. (PubMed id 22224631)1 Gurdol F....Isbir T. (Genet Test Mol Biomarkers 2012)
    1039. The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. (PubMed id 22135046)1 Fitzgerald D.W....Dannenberg A.J. (Cancer Prev Res (Phila) 2012)
    1040. Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer. (PubMed id 22782583)1 Zhang H.T....Li L. (Genet. Mol. Res. 2012)
    1041. Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKI^, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas. (PubMed id 22824620)1 Liu X.P....Chai C.Y. (Toxicol In Vitro 2012)
    1042. Induction of cyclooxygenase (COX)-2 in human vaginal epithelial cells in response to TLR ligands and TNF-I+. (PubMed id 22235849)1 Joseph T....Doncel G.F. (Am. J. Reprod. Immunol. 2012)
    1043. Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. (PubMed id 22696230)1 Chung L.Y....Sun K.H. (Clin. Cancer Res. 2012)
    1044. IL1I^-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells. (PubMed id 22884582)1 Zhu Y....Lance P. (Exp. Cell Res. 2012)
    1045. Cyclooxygenase-2-765G&gt;C functional promoter polymorphism and its association with oral squamous cell carcinoma. (PubMed id 22887904)1 Lakshmi A....Kaiser J. (J Investig Clin Dent 2012)
    1046. Oxidases and oxygenases in regulation of neutrophil redox pathways in BehAset's disease patients. (PubMed id 21699462)1 Melikoglu M.A....Aslan M. (J Enzyme Inhib Med Chem 2012)
    1047. Epidermal growth factor-stimulated human cervical cancer cell growth is associated with EGFR and cyclin D1 activation, independent of COX-2 expression levels. (PubMed id 21946890)