Aliases for PTGS2 Gene
Aliases for PTGS2 Gene
External Ids for PTGS2 Gene
- HGNC: 9605
- Entrez Gene: 5743
- Ensembl: ENSG00000073756
- OMIM: 600262
- UniProtKB: P35354
Previous GeneCards Identifiers for PTGS2 Gene
- GC01M184166
- GC01M182068
- GC01M183160
- GC01M183879
- GC01M183372
- GC01M184907
- GC01M157875
Summaries for PTGS2 Gene
-
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
GeneCards Summary for PTGS2 Gene
PTGS2 (Prostaglandin-Endoperoxide Synthase 2) is a Protein Coding gene. Diseases associated with PTGS2 include Colorectal Adenoma and Peptic Ulcer Disease. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and lipid binding. An important paralog of this gene is PTGS1.
UniProtKB/Swiss-Prot for PTGS2 Gene
-
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
-
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is expressed in cells in three isoforms. COX-1 (constitutive) and COX-2 (inducible) isoforms catalyze the rate-limiting step of prostaglandin production.
Additional gene information for PTGS2 Gene
- Monarch Initiative
- Search for PTGS2 at DataMed
- Search for PTGS2 at HumanCyc
No data available for fRNAdb sequence ontologies and piRNA Summary for PTGS2 Gene
Genomics for PTGS2 Gene
GeneHancer (GH) Regulatory Elements for PTGS2 Gene
- Top Transcription factor binding sites by QIAGEN in the PTGS2 gene promoter:
Regulatory Element Products
Genomic Locations for PTGS2 Gene
- chr1:186,671,791-186,680,427
- (GRCh38/hg38)
- Size:
- 8,637 bases
- Orientation:
- Minus strand
- chr1:186,640,923-186,649,559
- (GRCh37/hg19)
Genomic View for PTGS2 Gene
- Cytogenetic band:
-
- 1q31.1 by Ensembl
- 1q31.1 by Entrez Gene
- 1q31.1 by HGNC


RefSeq DNA sequence for PTGS2 Gene
Proteins for PTGS2 Gene
-
Protein details for PTGS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35354-PGH2_HUMAN
- Recommended name:
- Prostaglandin G/H synthase 2
- Protein Accession:
- P35354
- A8K802
- Q16876
Protein attributes for PTGS2 Gene
- Size:
- 604 amino acids
- Molecular mass:
- 68996 Da
- Cofactor:
- Name=heme b; Xref=ChEBI:CHEBI:60344;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PGHS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PGHS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
- PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimers disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
- The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
Protein Expression for PTGS2 Gene
Selected DME Specific Peptides for PTGS2 Gene
- P35354:
-
- AIFGETMVE
- MFAFFAQHFTHQFFKT
- HLSGYHF
- YNNSILLEHG
- WLREHNRVCD
- FNEYRKRF
- YVQHLSGY
- LYHWHPL
- LGHGVDL
- LLVEKPRP
- CDCTRTG
- LRLFKDGK
- VGQEVFGL
- AGRVAGG
- RTGFYGENC
- SFEELTGEKEM
- IINTASI
- RLFKDGKMKYQ
- LYGDIDA
- RLILIGETIKI
- YWKPSTFGG
- LKPTPNTVHYILTHFKG
- ASIDQSR
- PCQNRGVCMSVGFDQY
- FIPDPQG
- RLFKDGK
- YKSWEAFSNLSYYTRALPPV
- YPPTVKDTQ
- LKFDPELLF
- GAPFSLKGL
Post-translational modifications for PTGS2 Gene
- S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.
- Glycosylation at isoforms=53, Asn130, isoforms=396, and isoforms=580
Other Protein References for PTGS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PTGS2 (COX-2)
- Cell Signaling Technology (CST) Antibodies for PTGS2 (COX-2)
-
Custom Antibody ServicesOriGene Antibodies for PTGS2
- AM05211FC-N
- AM05211PU-N
- AM05213PU-N
- AP00118PU-N
- AP07624SU-N
- AP08507PU-N
- AP20194PU-N
- AP23344PU-N
- AP31178PU-N
- AP53500PU-N
- DRM006
- TA302755
- TA313292
- TA319280
- TA326006
- TA353760
- TA353761
- TA590771
- TA805224
- CF805224
- TA805286
- CF805286
- TA805287
- CF805287
- TA805307
- CF805307
- TA805310
- CF805310
- TA805311
- CF805311
- TA805365
- CF805365
- TA805370
- CF805370
- Novus Biologicals Antibodies for PTGS2
-
Abcam antibodies for PTGS2
-
Cloud-Clone Corp. Antibodies for PTGS2
- Invitrogen Antibodies for PTGS2
- antibodies-online: Search results for 234 available PTGS2 Antibodies ranked by validation data
- Compare Top PTGS2 Antibodies
-
Recommended
- 150 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 72 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 60 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 7 IHC (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- GeneTex PTGS2 antibody for PTGS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTGS2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PTGS2
- Origene Custom Protein Services for PTGS2
- Sino Biological Cell Lysates for PTGS2
- Sino Biological Recombinant Proteins for PTGS2
-
Cloud-Clone Corp. Proteins for PTGS2
- Search GeneTex for Proteins for PTGS2
-
Abcam proteins for PTGS2
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for PTGS2 (COX-2)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for PTGS2 (COX-2)
-
Cloud-Clone Corp. Assay Kits for PTGS2
-
Abcam assays for PTGS2
Domains & Families for PTGS2 Gene
Gene Families for PTGS2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- FDA approved drug targets
- Predicted secreted proteins
Protein Domains for PTGS2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGS2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35354- Family:
-
- Belongs to the prostaglandin G/H synthase family.
Function for PTGS2 Gene
Molecular function for PTGS2 Gene
- GENATLAS Biochemistry:
- prostaglandin G/H synthase 2,mitogen and cytokine inducible form (lipocalin family,Kernel group),monomer,potent mediator of inflammation,playing a minor role in colorectal carcinogenesis,overexpressed in squamous cell carcinoma of the head and neck,putatively involved in the tumor tissue response to necrosis
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=16.2 uM for arachidonate (in absence of sodium nitroprusside NO donor) {ECO:0000269 PubMed:16373578}; KM=17.0 uM for arachidonate (in presence of sodium nitroprusside NO donor) {ECO:0000269 PubMed:16373578}; Vmax=81.3 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor) {ECO:0000269 PubMed:16373578}; Vmax=132 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor) {ECO:0000269 PubMed:16373578};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
- UniProtKB/Swiss-Prot Function:
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
- UniProtKB/Swiss-Prot Induction:
- By cytokines and mitogens.
Enzyme Numbers (IUBMB) for PTGS2 Gene
Phenotypes From GWAS Catalog for PTGS2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004601 | peroxidase activity | TAS,IEA | -- |
GO:0004666 | prostaglandin-endoperoxide synthase activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 24089527 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | IEA | -- |
Phenotypes for PTGS2 Gene
- MGI mutant phenotypes for PTGS2:
-
inferred from 13 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for PTGS2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Effect on mitosis
- Increased shRNA abundance (Z-score > 2)
- Increased Nanog expression
Animal Models for PTGS2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PTGS2
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS2 gene
- Search ViGene Biosciences for PTGS2
CRISPR Products
-
OriGene CRISPR knockouts for PTGS2
- genomics-online: gRNA clones - Search results for available PTGS2 gene related products
- Applied Biological Materials CRISPR for PTGS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGS2
- GenScript: Design CRISPR guide RNA sequences for PTGS2
miRNA for PTGS2 Gene
- miRTarBase miRNAs that target PTGS2
-
- hsa-mir-16-5p (MIRT001426)
- hsa-let-7b-5p (MIRT001603)
- hsa-mir-101-3p (MIRT004297)
- hsa-mir-26b-5p (MIRT004659)
- hsa-mir-137 (MIRT006329)
- hsa-mir-143-3p (MIRT006757)
- hsa-mir-335-5p (MIRT017755)
- hsa-mir-132-3p (MIRT021768)
- hsa-mir-128-3p (MIRT021956)
- hsa-mir-124-3p (MIRT022542)
- hsa-mir-181a-5p (MIRT025094)
- hsa-mir-199a-3p (MIRT052956)
- hsa-mir-199a-5p (MIRT054370)
- hsa-mir-146a-5p (MIRT437352)
- hsa-mir-589-5p (MIRT437360)
- hsa-mir-558 (MIRT437813)
- hsa-mir-379-3p (MIRT439871)
- hsa-mir-26a-5p (MIRT732182)
- hsa-mir-144-3p (MIRT732183)
- hsa-mir-204-5p (MIRT732465)
miRNA Products
- Search ViGene Biosciences for PTGS2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGS2
- Browse OriGene Inhibitory RNA Products For PTGS2
- genomics-online: shRNA clones - Search results for available PTGS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS2 gene
Clone Products
- Sino Biological Human cDNA Clone for PTGS2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTGS2
- genomics-online: cdna clones - Search results for available PTGS2 gene related products
- orf clones - Search results for available PTGS2 gene related products
- Applied Biological Materials Clones for PTGS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PTGS2
-
ViGene Biosciences adenoviral particle packaged cDNA for PTGS2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGS2 Gene
Localization for PTGS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGS2 Gene
- Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
- Endoplasmic reticulum (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | IEA,ISS | -- |
GO:0005783 | endoplasmic reticulum | IEA,IDA | 24089527 |
GO:0005788 | endoplasmic reticulum lumen | TAS | 24089527 |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
Pathways & Interactions for PTGS2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling | ||
2 | Arachidonic acid metabolism | ||
3 | Metabolism |
.37
|
|
4 | aspirin triggered resolvin D biosynthesis | ||
5 | Cytokine Signaling in Immune system |
Pathways by source for PTGS2 Gene
3 Cell Signaling Technology pathways for PTGS2 Gene
18 BioSystems pathways for PTGS2 Gene
14 Reactome pathways for PTGS2 Gene
3 PharmGKB pathways for PTGS2 Gene
18 KEGG pathways for PTGS2 Gene
10 GeneGo (Thomson Reuters) pathways for PTGS2 Gene
13 Qiagen pathways for PTGS2 Gene
UniProtKB/Swiss-Prot P35354-PGH2_HUMAN
- Pathway: Lipid metabolism; prostaglandin biosynthesis.
Interacting Proteins for PTGS2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001516 | prostaglandin biosynthetic process | NAS | 20448152 |
GO:0001525 | angiogenesis | IEA | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006633 | fatty acid biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for PTGS2 Gene
Drugs & Compounds for PTGS2 Gene
(188) Drugs for PTGS2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ibuprofen | Approved | Pharma | Channel blocker, Target, Enzyme, inhibitor | 547 | ||
Rofecoxib | Approved, Investigational, Withdrawn | Pharma | Inhibition, Inhibitor, Target, inhibitor | COX-2 inhibitor | 31 | |
Celecoxib | Approved, Investigational | Pharma | Inhibition, Inhibitor, Target, inhibitor | Selective cyclooxygenase-2 (COX-2) inhibitor | 459 | |
Lumiracoxib | Approved, Investigational | Pharma | Inhibition, Inhibitor, Target, inhibitor | 17 | ||
Valdecoxib | Approved, Investigational, Withdrawn | Pharma | Inhibition, Inhibitor, Target, inhibitor | COX-2 inhibitor | 30 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
3-Hydroxymethylantipyrine |
|
18125-49-0 |
|
|||
4'-Hydroxydiclofenac |
|
64118-84-9 | ||||
5'-Hydroxylornoxicam |
|
|
||||
5'-Hydroxypiroxicam |
|
77459-78-0 | ||||
6-Hydroxymethyletoricoxib |
|
(4) Tocris Compounds for PTGS2 Gene
Compound | Action | Cas Number |
---|---|---|
NCX 4040 | NO-donating aspirin; anti-inflammatory and antitumor | 287118-97-2 |
NCX 466 | Cyclooxygenase-inhibiting nitric oxide donor | 1262956-64-8 |
Niflumic acid | Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist | 4394-00-7 |
Resveratrol | Cyclooxygenase inhibitor | 501-36-0 |
(64) ApexBio Compounds for PTGS2 Gene
Compound | Action | Cas Number |
---|---|---|
(R)-(-)-Ibuprofen | 51146-57-7 | |
(S)-(+)-Ibuprofen | 51146-56-6 | |
Aceclofenac | 89796-99-6 | |
Acemetacin | 53164-05-9 | |
Acetaminophen | 103-90-2 | |
Amfenac Sodium Monohydrate | 61618-27-7 | |
Ampiroxicam | 99464-64-9 | |
Asaraldehyde | 4460-86-0 | |
Aspirin (Acetylsalicylic acid) | Cyclooxygenase (COX) inhibitor | 50-78-2 |
ATB-346 | Non-steroidal anti-inflammatory drug | 1226895-20-0 |
Bismuth Subsalicylate | 14882-18-9 | |
Bromfenac Sodium | 91714-93-1 | |
Bufexamac | 2438-72-4 | |
Carprofen | 53716-49-7 | |
Celecoxib | Selective cyclooxygenase-2 (COX-2) inhibitor | 169590-42-5 |
Deracoxib | 169590-41-4 | |
Diclofenac | 15307-86-5 | |
Diclofenac Sodium | COX inhibitor | 15307-79-6 |
Diosgenin | 512-04-9 | |
DuP 697 | 88149-94-4 | |
Etodolac | COX-2 inhibitor | 41340-25-4 |
Etoricoxib | Specific COX-2 inhibitor | 202409-33-4 |
Firocoxib | 189954-96-9 | |
FK 3311 | Selective COX-2 inhibitor | 116686-15-8 |
Flunixin Meglumin | 42461-84-7 | |
FR 122047 hydrochloride | 130717-51-0 | |
Ibuprofen | 15687-27-1 | |
Ibuprofen Lysine | COX inhibitor | 57469-77-9 |
Iguratimod | COX-2 inhibitor,inhibits IL-1,IL-6,IL-8 and tumour necrosis factor. | 123663-49-0 |
Indomethacin | Cox inhibitor | 53-86-1 |
Ketoprofen | 22071-15-4 | |
Ketorolac | 74103-06-3 | |
Ketorolac tromethamine salt | 74103-07-4 | |
Licofelone | 156897-06-2 | |
Lornoxicam | COX-1/COX-2 inhibitor | 70374-39-9 |
Loxoprofen | 68767-14-6 | |
Lumiracoxib | 220991-20-8 | |
Meclofenamate Sodium | 6385-02-0 | |
Mefenamic Acid | Anti-inflammatory agent | 61-68-7 |
Meloxicam (Mobic) | Nonsteroidal anti-inflammatory drug | 71125-38-7 |
MF63 | MPGES-1 inhibitor | 892549-43-8 |
Nabumetone | 42924-53-8 | |
Naproxen Sodium | cyclooxygenase inhibitor | 26159-34-2 |
NCX 4040 | 287118-97-2 | |
NCX 466 | 1262956-64-8 | |
Nimesulide | Non-steroidal anti-inflammatory drug | 51803-78-2 |
NS 398 | COX-2 inhibitor and anti-inflammatory agent | 123653-11-2 |
Oxaprozin | Anti-inflammatory drug | 21256-18-8 |
Parecoxib | 198470-84-7 | |
Parecoxib Sodium | 198470-85-8 | |
Phenacetin | Non-opioid analgesic | 62-44-2 |
Piroxicam | Prostaglandin synthesis/Coxinhibitor | 36322-90-4 |
Rofecoxib | COX-2 inhibitor | 162011-90-7 |
Saikosaponin A | COX-2 and iNOS inhibitor | 20736-09-8 |
Salicylic acid | 69-72-7 | |
SC 236 | 170569-86-5 | |
SC 58125 | 162054-19-5 | |
Sulindac | Anti-inflammatory agent;COX inhibitor | 38194-50-2 |
Tenidap | 120210-48-2 | |
Tolfenamic Acid | Non-steroidal anti-inflammatory drug | 13710-19-5 |
Triflusal | 322-79-2 | |
Valdecoxib | COX-2 inhibitor | 181695-72-7 |
Wogonin | COX-2 inhibitor,anti-inflammatory agent | 632-85-9 |
Zaltoprofen | Cyclooxygenase (COX) inhibitor | 74711-43-6 |
Transcripts for PTGS2 Gene
mRNA/cDNA for PTGS2 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (101) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTGS2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PTGS2
- genomics-online: gRNA clones - Search results for available PTGS2 gene related products
- Applied Biological Materials CRISPR for PTGS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGS2
- GenScript: Design CRISPR guide RNA sequences for PTGS2
miRNA Products
- Search ViGene Biosciences for PTGS2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGS2
- Browse OriGene Inhibitory RNA Products For PTGS2
- genomics-online: shRNA clones - Search results for available PTGS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS2 gene
Clone Products
- Sino Biological Human cDNA Clone for PTGS2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTGS2
- genomics-online: cdna clones - Search results for available PTGS2 gene related products
- orf clones - Search results for available PTGS2 gene related products
- Applied Biological Materials Clones for PTGS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||
SP5: |
Expression for PTGS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Mural Granulosa Cells Antral Follicle
- Oviduct
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- human epithelial stem cells(Yang R et. al. 2014)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Monocytes Peripheral Blood
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Detroit 551
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
- Bone (Muscoskeletal System)
- Dermis (Integumentary System)
- Epidermis (Integumentary System)
-
Prostate (Endocrine System)
-
Smooth Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PTGS2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTGS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of PTGS2 Gene:
PTGS2SOURCE GeneReport for Unigene cluster for PTGS2 Gene:
Hs.196384Evidence on tissue expression from TISSUES for PTGS2 Gene
- Blood(4.8)
- Lung(4.6)
- Heart(4.5)
- Intestine(3.4)
- Nervous system(3.3)
- Bone marrow(2.9)
- Liver(2.9)
- Stomach(2.9)
- Kidney(2.8)
- Muscle(2.7)
- Lymph node(2.6)
- Pancreas(2.5)
- Skin(2.5)
- Bone(2.2)
- Gall bladder(2.2)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PTGS2
-
OriGene qPCR primer pairs for PTGS2
- genomics-online: primer clones - Search results for available PTGS2 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGS2 Gene
Orthologs for PTGS2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PTGS2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | COX-2 34 |
|
OneToOne | |
PTGS2 33 |
|
||||
cow (Bos Taurus) |
Mammalia | PGHS-2 34 |
|
OneToOne | |
PTGS2 33 |
|
||||
platypus (Ornithorhynchus anatinus) |
Mammalia | PTGS2 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Ptgs2 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ptgs2 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PTGS2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PTGS2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PTGS2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ptgs2 33 |
|
||
Str.16299 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.33329 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ptgs2b 33 34 |
|
||
ptgs2a 34 |
|
OneToMany | |||
ptgs2 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11687 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
CSA.3689 34 |
|
ManyToMany |
- Species where no ortholog for PTGS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PTGS2 Gene
(2) SIMAP similar genes for PTGS2 Gene using alignment to 3 proteins:
Variants for PTGS2 Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000357628 | -- | 186,671,890(-) | G/A | 3_prime_UTR_variant | |
rs1000395206 | -- | 186,679,521(-) | C/T | intron_variant | |
rs1000781846 | -- | 186,680,425(-) | G/A | 5_prime_UTR_variant | |
rs1000808915 | -- | 186,672,081(-) | A/T | 3_prime_UTR_variant | |
rs1003511546 | -- | 186,681,943(-) | C/G | upstream_transcript_variant |
Additional Variant Information for PTGS2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGS2 Gene
Disorders for PTGS2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
colorectal adenoma |
|
|
peptic ulcer disease |
|
|
bursitis |
|
|
gastric ulcer |
|
|
osteoid osteoma |
|
|
Additional Disease Information for PTGS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGS2 Gene
Publications for PTGS2 Gene
- Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. (PMID: 17181859) Shen J … Santella RM (Breast cancer research : BCR 2006) 3 22 25 44 58
- Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 22 44 58
- Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. (PMID: 19755647) Barry EL … Baron JA (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 44 58
- Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese. (PMID: 17234302) Ma SL … Lam LC (Neurobiology of aging 2008) 3 22 44 58
- Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. (PMID: 18349295) Ferguson HR … Hardie LJ (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 22 44 58
Products for PTGS2 Gene
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- Taconic Biosciences Mouse Models for PTGS2
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- Humanized Mice
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- 150 WB Antibodies (anti-human)
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- 1 EIA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
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- 24 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
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- 1 EIA Antibody (anti-mouse)
- 60 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 7 IHC (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- antibodies-online: Search results for 69 available PTGS2 Elisa Kits ranked by validation data
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- GeneTex PTGS2 antibody for PTGS2
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- ViGene Biosciences adenoviral particle packaged cDNA for PTGS2 gene
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Sources for PTGS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
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- (105) Taconic Biosciences
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- (114) diseasecard
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- (148) abm
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew