Aliases for PTGS1 Gene
Aliases for PTGS1 Gene
External Ids for PTGS1 Gene
- HGNC: 9604
- Entrez Gene: 5742
- Ensembl: ENSG00000095303
- OMIM: 176805
- UniProtKB: P23219
Previous GeneCards Identifiers for PTGS1 Gene
- GC09P116237
- GC09P116779
- GC09P118586
- GC09P120509
- GC09P122212
- GC09P124173
- GC09P125133
- GC09P094748
Summaries for PTGS1 Gene
-
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for PTGS1 Gene
PTGS1 (Prostaglandin-Endoperoxide Synthase 1) is a Protein Coding gene. Diseases associated with PTGS1 include Dyspepsia and Chronic Cystitis. Among its related pathways are Platelet activation and Arachidonic acid metabolism. GO annotations related to this gene include heme binding and dioxygenase activity. An important paralog of this gene is PTGS2.
UniProtKB/Swiss-Prot for PTGS1 Gene
-
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
-
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is expressed in cells in three isoforms. COX-1 (constitutive) and COX-2 (inducible) isoforms catalyze the rate-limiting step of prostaglandin production.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGS1 Gene
Genomics for PTGS1 Gene
Regulatory Elements for PTGS1 Gene
Enhancers for PTGS1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PTGS1 on UCSC Golden Path with GeneCards custom track
Promoters for PTGS1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PTGS1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PTGS1 gene promoter:
Regulatory Element Products
Genomic Location for PTGS1 Gene
- Chromosome:
- 9
- Start:
- 122,370,530 bp from pter
- End:
- 122,395,705 bp from pter
- Size:
- 25,176 bases
- Orientation:
- Plus strand
Genomic View for PTGS1 Gene
Genes around PTGS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q33.2 by Ensembl
- 9q32-q33.3 by Entrez Gene
- 9q32-q33.3 by HGNC
PTGS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTGS1 Gene
Proteins for PTGS1 Gene
-
Protein details for PTGS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23219-PGH1_HUMAN
- Recommended name:
- Prostaglandin G/H synthase 1
- Protein Accession:
- P23219
- A8K1V7
- B4DHQ2
- B4E2S5
- Q15122
- Q3HY28
- Q3HY29
- Q5T7T6
- Q5T7T7
- Q5T7T8
Protein attributes for PTGS1 Gene
- Size:
- 599 amino acids
- Molecular mass:
- 68686 Da
- Cofactor:
- Name=heme b; Xref=ChEBI:CHEBI:60344;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PGHS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PGHS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
- PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimers disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
- The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
- SequenceCaution:
-
- Sequence=CAI14716.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for PTGS1 Gene
Selected DME Specific Peptides for PTGS1 Gene
Post-translational modifications for PTGS1 Gene
Other Protein References for PTGS1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PTGS1
- R&D Systems Antibodies for PTGS1 (COX-1)
- Cell Signaling Technology (CST) Antibodies for PTGS1 (COX-1)
- Novus Biologicals Antibodies for PTGS1
-
Cloud-Clone Corp. Antibodies for PTGS1
- Invitrogen Antibodies for PTGS1
- antibodies-online Antibodies for PTGS1: See all 129
- GeneTex PTGS1 antibody for PTGS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTGS1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGS1
- Origene Custom Protein Services for PTGS1
-
Cloud-Clone Corp. Proteins for PTGS1
- antibodies-online Proteins for PTGS1: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PTGS1
Assay Products
- Enzo Life Sciences assays for PTGS1
-
Cloud-Clone Corp Assay Kits for PTGS1
- antibodies-online Kits for PTGS1: See all 55
Domains & Families for PTGS1 Gene
Protein Domains for PTGS1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P23219UniProtKB/Swiss-Prot:
PGH1_HUMAN :- Contains 1 EGF-like domain.
- Belongs to the prostaglandin G/H synthase family.
- Domain:
-
- Contains 1 EGF-like domain.
- Family:
-
- Belongs to the prostaglandin G/H synthase family.
Function for PTGS1 Gene
Molecular function for PTGS1 Gene
- GENATLAS Biochemistry:
- prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a dioxygenase,then as a peroxidase (lipocalin family,Kernel group),monomer,potent mediator of inflammation
- UniProtKB/Swiss-Prot CatalyticActivity:
- Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
- UniProtKB/Swiss-Prot Function:
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Enzyme Numbers (IUBMB) for PTGS1 Gene
- EC 1.14.99.1 63 4
- EC 1.14.99 63
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for PTGS1 Gene
- MGI mutant phenotypes for PTGS1:
-
inferred from 2 alleles
- cellular phenotype
- mortality/aging
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- immune system phenotype
- cardiovascular system phenotype
- integument phenotype
- growth/size/body region phenotype
- hematopoietic system phenotype
- tumorigenesis
- homeostasis/metabolism phenotype
- digestive/alimentary phenotype
- respiratory system phenotype
- nervous system phenotype
- muscle phenotype
- skeleton phenotype
- renal/urinary system phenotype
- other phenotype
- GenomeRNAi human phenotypes for PTGS1:
Animal Models for PTGS1 Gene
- MGI Knock Outs for PTGS1:
-
- Ptgs1 tm1Unc
Animal Model Products
-
Taconic Biosciences Mouse Models for PTGS1
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS1 gene
- Search ViGene Biosciences for PTGS1
CRISPR Products
-
OriGene CRISPR knockouts for PTGS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGS1
- GenScript: Design CRISPR guide RNA sequences for PTGS1
miRNA for PTGS1 Gene
- miRTarBase miRNAs that target PTGS1
-
- hsa-mir-124-3p (MIRT023020)
- hsa-mir-18a-3p (MIRT040875)
- hsa-mir-7153-5p (MIRT495088)
- hsa-mir-3651 (MIRT495089)
- hsa-mir-632 (MIRT717679)
- hsa-mir-4288 (MIRT717680)
- hsa-mir-6515-5p (MIRT717681)
- hsa-mir-874-3p (MIRT717682)
- hsa-mir-7847-3p (MIRT717683)
- hsa-mir-346 (MIRT717684)
- hsa-mir-4741 (MIRT717685)
- hsa-mir-4675 (MIRT717686)
- hsa-mir-6797-5p (MIRT717687)
- hsa-mir-1249-5p (MIRT717688)
- hsa-mir-6876-3p (MIRT717689)
- hsa-mir-626 (MIRT717690)
- hsa-mir-146b-3p (MIRT717691)
- hsa-mir-6799-3p (MIRT717692)
- hsa-mir-3173-5p (MIRT717693)
- hsa-mir-7976 (MIRT717694)
- hsa-mir-4721 (MIRT717695)
- hsa-mir-3120-5p (MIRT717696)
- hsa-mir-324-3p (MIRT717697)
- hsa-mir-1913 (MIRT717698)
- hsa-mir-4324 (MIRT717699)
- hsa-mir-4319 (MIRT717700)
- hsa-mir-125b-5p (MIRT717701)
- hsa-mir-125a-5p (MIRT717702)
- hsa-mir-4446-3p (MIRT717703)
miRNA Products
- Search ViGene Biosciences for PTGS1
Clone Products
- OriGene clones in human for PTGS1
- OriGene ORF clones in human,mouse,rat for PTGS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTGS1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PTGS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGS1 Gene
Localization for PTGS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGS1 Gene
- Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| extracellular | 5 |
| golgi apparatus | 5 |
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| plasma membrane | 2 |
| cytoskeleton | 1 |
| lysosome | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
Pathways & Interactions for PTGS1 Gene
More details on SuperPathways for PTGS1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.38
|
|
| 2 | Ibuprofen Pathway, Pharmacodynamics | ||
| 3 | Arachidonic acid metabolism | ||
| 4 | Linoleic acid metabolism | ||
| 5 | Platelet activation |
Pathways by source for PTGS1 Gene
2 Cell Signaling Technology pathways for PTGS1 Gene
4 BioSystems pathways for PTGS1 Gene
7 Reactome pathways for PTGS1 Gene
5 KEGG pathways for PTGS1 Gene
4 GeneGo (Thomson Reuters) pathways for PTGS1 Gene
1 Qiagen pathway for PTGS1 Gene
UniProtKB/Swiss-Prot P23219-PGH1_HUMAN
- Pathway: Lipid metabolism; prostaglandin biosynthesis.
Interacting Proteins for PTGS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | NAS | 1907252 |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0007612 | learning | IEA | -- |
| GO:0007613 | memory | IEA | -- |
No data available for SIGNOR curated interactions for PTGS1 Gene
Drugs & Compounds for PTGS1 Gene
(175) Drugs for PTGS1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Aspirin | Approved | Pharma | Channel blocker, inhibitor, Target | 1059 | ||
| Ibuprofen | Approved | Pharma | Channel blocker, inhibitor, Target, Enzyme | 467 | ||
| Ketoprofen | Approved | Pharma | Inhibition, Inhibitor, inhibitor, Target | 80 | ||
| Mefenamic acid | Approved | Pharma | Activator, inhibitor, Target | Anti-inflammatory agent | 6 | |
| Nabumetone | Approved | Pharma | inhibitor, Target | 6 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Dup 697 |
|
88149-94-4 |
|
|||
| NS 398 |
|
123653-11-2 |
|
|||
| valerylsalicylate |
|
Inhibition, Inhibitor |
|
|||
| 2-Hydroxychlorpropamide |
|
36892-36-1 |
|
|||
| 3-Dechloroethylifosfamide |
|
36761-83-8 |
(5) Tocris Compounds for PTGS1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| DuP 697 | Cyclooxygenase-2 (COX-2) inhibitor | 88149-94-4 |
| FR 122047 hydrochloride | Cyclooxygenase (COX-1) inhibitor | 130717-51-0 |
| NS 398 | Cyclooxygenase-2 (COX-2) inhibitor | 123653-11-2 |
| Piroxicam | Cyclooxygenase-1 (COX-1) inhibitor | 36322-90-4 |
| Resveratrol | Cyclooxygenase inhibitor | 501-36-0 |
(35) ApexBio Compounds for PTGS1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Acemetacin | 53164-05-9 | |
| Amfenac Sodium Monohydrate | 61618-27-7 | |
| Ampiroxicam | 99464-64-9 | |
| Asaraldehyde | 4460-86-0 | |
| Aspirin (Acetylsalicylic acid) | Cyclooxygenase (COX) inhibitor | 50-78-2 |
| ATB-346 | Non-steroidal anti-inflammatory drug | 1226895-20-0 |
| Bromfenac Sodium | 91714-93-1 | |
| Bufexamac | 2438-72-4 | |
| Celecoxib | Selective cyclooxygenase-2 (COX-2) inhibitor | 169590-42-5 |
| Diclofenac Sodium | COX inhibitor | 15307-79-6 |
| Diosgenin | 512-04-9 | |
| Etodolac | COX-2 inhibitor | 41340-25-4 |
| Flunixin Meglumin | 42461-84-7 | |
| Ibuprofen | 15687-27-1 | |
| Ibuprofen Lysine | COX inhibitor | 57469-77-9 |
| Indomethacin | Cox inhibitor | 53-86-1 |
| Ketoprofen | 22071-15-4 | |
| Ketorolac tromethamine salt | 74103-07-4 | |
| Licofelone | 156897-06-2 | |
| Lornoxicam | COX-1/COX-2 inhibitor | 70374-39-9 |
| Lumiracoxib | 220991-20-8 | |
| Meclofenamate Sodium | 6385-02-0 | |
| Mefenamic Acid | Anti-inflammatory agent | 61-68-7 |
| Meloxicam (Mobic) | Nonsteroidal anti-inflammatory drug | 71125-38-7 |
| Nabumetone | 42924-53-8 | |
| Nimesulide | Non-steroidal anti-inflammatory drug | 51803-78-2 |
| Oxaprozin | Anti-inflammatory drug | 21256-18-8 |
| Phenacetin | Non-opioid analgesic | 62-44-2 |
| Piroxicam | Prostaglandin synthesis/Coxinhibitor | 36322-90-4 |
| Rofecoxib | COX-2 inhibitor | 162011-90-7 |
| Sulindac | Anti-inflammatory agent;COX inhibitor | 38194-50-2 |
| Tolfenamic Acid | Non-steroidal anti-inflammatory drug | 13710-19-5 |
| Triflusal | 322-79-2 | |
| Valdecoxib | COX-2 inhibitor | 181695-72-7 |
| Zaltoprofen | Cyclooxygenase (COX) inhibitor | 74711-43-6 |
Transcripts for PTGS1 Gene
mRNA/cDNA for PTGS1 Gene
- (10) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (156) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTGS1 Gene
- Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PTGS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGS1
- GenScript: Design CRISPR guide RNA sequences for PTGS1
miRNA Products
- Search ViGene Biosciences for PTGS1
Clone Products
- OriGene clones in human for PTGS1
- OriGene ORF clones in human,mouse,rat for PTGS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PTGS1
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - |
Expression for PTGS1 Gene
mRNA differential expression in normal tissues according to GTEx for PTGS1 Gene
This gene is overexpressed in Bladder (x10.9), Colon - Sigmoid (x6.6), and Skin - Sun Exposed (Lower leg) (x4.1).
This gene is overexpressed in Urinary Bladder (25.0), Platelet (15.5), and Peripheral blood mononuclear cells (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGS1 Gene
SOURCE GeneReport for Unigene cluster for PTGS1 Gene Hs.201978
Primer Products
-
OriGene qPCR primer pairs and template standards for PTGS1
-
OriGene qPCR primer pairs for PTGS1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PTGS1 Gene
Orthologs for PTGS1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PTGS1 35 |
|
||
| PTGS1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PTGS1 35 |
|
||
| PTGS1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ptgs1 35 |
|
||
| Ptgs1 16 |
|
||||
| Ptgs1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PTGS1 35 |
|
||
| PTGS1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ptgs1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| -- 36 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTGS1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PTGS1 35 |
|
||
| PTGS1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PTGS1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptgs1 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6116 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptgs1 35 |
|
||
| ptgs1 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11882 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1052 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany | |
| CSA.3689 36 |
|
ManyToMany |
- Species with no ortholog for PTGS1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PTGS1 Gene
(1) SIMAP similar genes for PTGS1 Gene using alignment to 1 proteins:
Variants for PTGS1 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1236913 | - | 122,371,200(+) | TGCTC(C/T)GGTTC | reference, missense, utr-variant-5-prime | |
| rs3842787 | - | 122,371,228(+) | GCTCC(C/T)GCCGC | reference, missense, utr-variant-5-prime | |
| rs5791 | - | 122,386,512(+) | GCTGA(A/G)ATTTG | reference, missense | |
| rs5792 | - | 122,390,228(+) | ACCAC(A/G)TCCTG | reference, missense | |
| rs3842789 | - | 122,377,962(+) | TGACC(A/G)CTACC | reference, missense, utr-variant-5-prime |
Residual Variation Intolerance Score:
82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.77;
66.66% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PTGS1 Gene
- Human Gene Mutation Database (HGMD)
- PTGS1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGS1 Gene
Disorders for PTGS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dyspepsia |
|
|
| chronic cystitis |
|
|
| stevens-johnson syndrome/toxic epidermal necrolysis |
|
|
| rhinitis |
|
|
| stomach disease |
|
Search PTGS1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PTGS1
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGS1 Gene
Publications for PTGS1 Gene
- Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. (PMID: 1907252) Funk C.D. … Fitzgerald G.A. (FASEB J. 1991) 2 3 4 67
- Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis. (PMID: 17322116) Weinheimer E.M. … Trappe T.A. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007) 3 23 26
- Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. (PMID: 17319904) Guthikonda S. … Kleiman N.S. (J. Thromb. Haemost. 2007) 23 25 26
- Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models. (PMID: 16223958) Joo Y. … Suh Y.H. (Mol. Pharmacol. 2006) 23 25 26
- Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2. (PMID: 16403783) Warner T.D. … Mitchell J.A. (FASEB J. 2006) 23 25 26
Products for PTGS1 Gene
- R&D Systems Antibodies for PTGS1 (COX-1)
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- Custom Antibody ServicesOriGene Antibodies for PTGS1
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- antibodies-online Antibodies for PTGS1: See all 129
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- antibodies-online Proteins for PTGS1: See all 13
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- Search ViGene Biosciences for PTGS1
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- Santa Cruz Biotechnology (SCBT) Antibodies for PTGS1
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- Santa Cruz Biotechnology (SCBT) CRISPR for PTGS1
Sources for PTGS1 Gene
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