Aliases for PTGS1 Gene
Aliases for PTGS1 Gene
External Ids for PTGS1 Gene
- HGNC: 9604
- Entrez Gene: 5742
- Ensembl: ENSG00000095303
- OMIM: 176805
- UniProtKB: P23219
Previous GeneCards Identifiers for PTGS1 Gene
- GC09P116237
- GC09P116779
- GC09P118586
- GC09P120509
- GC09P122212
- GC09P124173
- GC09P125133
- GC09P094748
Summaries for PTGS1 Gene
-
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for PTGS1 Gene
PTGS1 (Prostaglandin-Endoperoxide Synthase 1) is a Protein Coding gene. Diseases associated with PTGS1 include Aspirin Resistance and Chronic Cystitis. Among its related pathways are Overview of nanoparticle effects and Platelet activation. Gene Ontology (GO) annotations related to this gene include heme binding and dioxygenase activity. An important paralog of this gene is PTGS2.
UniProtKB/Swiss-Prot for PTGS1 Gene
-
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
-
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is expressed in cells in three isoforms. COX-1 (constitutive) and COX-2 (inducible) isoforms catalyze the rate-limiting step of prostaglandin production.
Additional gene information for PTGS1 Gene
- Monarch Initiative
- Search for PTGS1 at DataMed
- Search for PTGS1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGS1 Gene
Genomics for PTGS1 Gene
GeneHancer (GH) Regulatory Elements for PTGS1 Gene
Regulatory Element Products
Genomic Locations for PTGS1 Gene
- chr9:122,370,530-122,395,705
- (GRCh38/hg38)
- Size:
- 25,176 bases
- Orientation:
- Plus strand
- chr9:125,132,824-125,157,982
- (GRCh37/hg19)
Genomic View for PTGS1 Gene
- Cytogenetic band:
-
- 9q33.2 by Ensembl
- 9q33.2 by Entrez Gene
- 9q33.2 by HGNC


RefSeq DNA sequence for PTGS1 Gene
Proteins for PTGS1 Gene
-
Protein details for PTGS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23219-PGH1_HUMAN
- Recommended name:
- Prostaglandin G/H synthase 1
- Protein Accession:
- P23219
- A8K1V7
- B4DHQ2
- B4E2S5
- Q15122
- Q3HY28
- Q3HY29
- Q5T7T6
- Q5T7T7
- Q5T7T8
Protein attributes for PTGS1 Gene
- Size:
- 599 amino acids
- Molecular mass:
- 68686 Da
- Cofactor:
- Name=heme b; Xref=ChEBI:CHEBI:60344;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PGHS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PGHS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
- PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimers disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
- The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
- SequenceCaution:
-
- Sequence=CAI14716.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for PTGS1 Gene
Selected DME Specific Peptides for PTGS1 Gene
- P23219:
-
- MFAFFAQHFTHQFFKT
- WLREHNRVCD
- FNEYRKRF
- LYHWHPL
- LGHGVDL
- AGRIGGGRN
- PVNPCCYYPCQ
- CDCTRTG
- LRLFKDGK
- FSNVSYYTR
- VGQEVFGL
- GNPICSP
- GPGFTKA
- DCPTPMG
- LYGDIDA
- RLILIGETIKI
- YWKPSTFGG
- SWESFSN
- YSYEQFLFNTSMLVDYGVEALVDAFSRQ
- FIPDPQG
- RLFKDGK
- TVRSNLIPSPPTYN
- LKFDPELLF
- GAPFSLKGL
Post-translational modifications for PTGS1 Gene
- Glycosylation at isoforms=2, 3, 5, 667, isoforms=2, 3, 5, 6103, and Asn143
Other Protein References for PTGS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PTGS1 (COX-1)
- Cell Signaling Technology (CST) Antibodies for PTGS1 (COX-1)
- Novus Biologicals Antibodies for PTGS1
-
Abcam antibodies for PTGS1
-
Cloud-Clone Corp. Antibodies for PTGS1
- Invitrogen Antibodies for PTGS1
- GeneTex PTGS1 antibody for PTGS1
-
Custom Antibody ServicesProSci Antibodies for PTGS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTGS1
Protein Products
-
OriGene Purified Proteins for PTGS1
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGS1
- Origene Custom Protein Services for PTGS1
-
Cloud-Clone Corp. Proteins for PTGS1
- Search GeneTex for Proteins for PTGS1
-
Abcam proteins for PTGS1
Assay Products
-
Cloud-Clone Corp. Assay Kits for PTGS1
Domains & Families for PTGS1 Gene
Gene Families for PTGS1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PTGS1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P23219- Family:
-
- Belongs to the prostaglandin G/H synthase family.
Function for PTGS1 Gene
Molecular function for PTGS1 Gene
- GENATLAS Biochemistry:
- prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a dioxygenase,then as a peroxidase (lipocalin family,Kernel group),monomer,potent mediator of inflammation
- UniProtKB/Swiss-Prot CatalyticActivity:
- Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
- UniProtKB/Swiss-Prot Function:
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Enzyme Numbers (IUBMB) for PTGS1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004601 | peroxidase activity | TAS | -- |
GO:0004666 | prostaglandin-endoperoxide synthase activity | TAS | -- |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0020037 | heme binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PTGS1 Gene
- MGI mutant phenotypes for PTGS1:
-
inferred from 2 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- GenomeRNAi human phenotypes for PTGS1:
Animal Models for PTGS1 Gene
- MGI Knock Outs for PTGS1:
-
- Ptgs1 tm1Unc
Animal Model Products
-
Taconic Biosciences Mouse Models for PTGS1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTGS1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS1 gene
- Search ViGene Biosciences for PTGS1
CRISPR Products
-
OriGene CRISPR knockouts for PTGS1
- genomics-online: gRNA clones - Search results for 113 available COX1 gene related products
- Overview of 113 available COX1 gene related products
- Applied Biological Materials CRISPR for PTGS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGS1
- GenScript: Design CRISPR guide RNA sequences for PTGS1
miRNA for PTGS1 Gene
- miRTarBase miRNAs that target PTGS1
-
- hsa-mir-124-3p (MIRT023020)
- hsa-mir-18a-3p (MIRT040875)
- hsa-mir-7153-5p (MIRT495088)
- hsa-mir-3651 (MIRT495089)
- hsa-mir-632 (MIRT717679)
- hsa-mir-4288 (MIRT717680)
- hsa-mir-6515-5p (MIRT717681)
- hsa-mir-874-3p (MIRT717682)
- hsa-mir-7847-3p (MIRT717683)
- hsa-mir-346 (MIRT717684)
- hsa-mir-4741 (MIRT717685)
- hsa-mir-4675 (MIRT717686)
- hsa-mir-6797-5p (MIRT717687)
- hsa-mir-1249-5p (MIRT717688)
- hsa-mir-6876-3p (MIRT717689)
- hsa-mir-626 (MIRT717690)
- hsa-mir-146b-3p (MIRT717691)
- hsa-mir-6799-3p (MIRT717692)
- hsa-mir-3173-5p (MIRT717693)
- hsa-mir-7976 (MIRT717694)
- hsa-mir-4721 (MIRT717695)
- hsa-mir-3120-5p (MIRT717696)
- hsa-mir-324-3p (MIRT717697)
- hsa-mir-1913 (MIRT717698)
- hsa-mir-4324 (MIRT717699)
- hsa-mir-4319 (MIRT717700)
- hsa-mir-125b-5p (MIRT717701)
- hsa-mir-125a-5p (MIRT717702)
- hsa-mir-4446-3p (MIRT717703)
miRNA Products
- Search ViGene Biosciences for PTGS1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PTGS1
- Browse OriGene Inhibitory RNA Products For PTGS1
- genomics-online: shRNA clones - Search results for 113 available COX1 gene related products
- Overview of 113 available COX1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS1 gene
Clone Products
-
OriGene ORF clones in human for PTGS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PTGS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTGS1
- Applied Biological Materials Clones for PTGS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PTGS1
-
ViGene Biosciences adenoviral particle packaged cDNA for PTGS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS1 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGS1 Gene
Localization for PTGS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGS1 Gene
- Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
- Golgi apparatus (3)
- Vesicles (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001750 | photoreceptor outer segment | IEA | -- |
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | IDA,ISS | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
Pathways & Interactions for PTGS1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Arachidonic acid metabolism |
.01
|
|
2 | Metabolism |
.37
|
|
3 | Cytochrome P450 - arranged by substrate type | ||
4 | Linoleic acid metabolism | ||
5 | Platelet activation |
Pathways by source for PTGS1 Gene
2 Cell Signaling Technology pathways for PTGS1 Gene
5 BioSystems pathways for PTGS1 Gene
7 Reactome pathways for PTGS1 Gene
5 KEGG pathways for PTGS1 Gene
4 GeneGo (Thomson Reuters) pathways for PTGS1 Gene
1 Qiagen pathway for PTGS1 Gene
UniProtKB/Swiss-Prot P23219-PGH1_HUMAN
- Pathway: Lipid metabolism; prostaglandin biosynthesis.
Interacting Proteins for PTGS1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001516 | prostaglandin biosynthetic process | ISS | -- |
GO:0006629 | lipid metabolic process | NAS | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006633 | fatty acid biosynthetic process | IEA | -- |
GO:0006693 | prostaglandin metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for PTGS1 Gene
Drugs & Compounds for PTGS1 Gene
(202) Drugs for PTGS1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target, inhibitor | 1232 | ||
Acetaminophen | Approved | Pharma | Target, inhibitor | 1014 | ||
Ibuprofen | Approved | Pharma | Channel blocker, Target, Enzyme, inhibitor | 547 | ||
Ketoprofen | Approved, Vet_approved | Pharma | Inhibition, Inhibitor, Target, inhibitor | 92 | ||
Ketorolac | Approved | Pharma | Target, inhibitor | 340 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
valerylsalicylate |
|
Inhibition, Inhibitor |
|
|||
2-Hydroxychlorpropamide |
|
36892-36-1 |
|
|||
3-Dechloroethylifosfamide |
|
36761-83-8 | ||||
3'-Hydroxyhexobarbital |
|
427-29-2 | ||||
3-Hydroxymethylantipyrine |
|
18125-49-0 |
|
(4) Tocris Compounds for PTGS1 Gene
Compound | Action | Cas Number |
---|---|---|
NCX 4040 | NO-donating aspirin; anti-inflammatory and antitumor | 287118-97-2 |
NCX 466 | Cyclooxygenase-inhibiting nitric oxide donor | 1262956-64-8 |
Niflumic acid | Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist | 4394-00-7 |
Resveratrol | Cyclooxygenase inhibitor | 501-36-0 |
(61) ApexBio Compounds for PTGS1 Gene
Compound | Action | Cas Number |
---|---|---|
(R)-(-)-Ibuprofen | 51146-57-7 | |
(S)-(+)-Ibuprofen | 51146-56-6 | |
Aceclofenac | 89796-99-6 | |
Acemetacin | 53164-05-9 | |
Acetaminophen | 103-90-2 | |
Amfenac Sodium Monohydrate | 61618-27-7 | |
Ampiroxicam | 99464-64-9 | |
Asaraldehyde | 4460-86-0 | |
Aspirin (Acetylsalicylic acid) | Cyclooxygenase (COX) inhibitor | 50-78-2 |
ATB-346 | Non-steroidal anti-inflammatory drug | 1226895-20-0 |
Bromfenac Sodium | 91714-93-1 | |
Bufexamac | 2438-72-4 | |
Celecoxib | Selective cyclooxygenase-2 (COX-2) inhibitor | 169590-42-5 |
Deracoxib | 169590-41-4 | |
Diclofenac | 15307-86-5 | |
Diclofenac Sodium | COX inhibitor | 15307-79-6 |
Diosgenin | 512-04-9 | |
DuP 697 | 88149-94-4 | |
Etodolac | COX-2 inhibitor | 41340-25-4 |
Etoricoxib | Specific COX-2 inhibitor | 202409-33-4 |
Firocoxib | 189954-96-9 | |
FK 3311 | Selective COX-2 inhibitor | 116686-15-8 |
Flunixin Meglumin | 42461-84-7 | |
FR 122047 hydrochloride | 130717-51-0 | |
Ibuprofen | 15687-27-1 | |
Ibuprofen Lysine | COX inhibitor | 57469-77-9 |
Iguratimod | COX-2 inhibitor,inhibits IL-1,IL-6,IL-8 and tumour necrosis factor. | 123663-49-0 |
Indomethacin | Cox inhibitor | 53-86-1 |
Ketoprofen | 22071-15-4 | |
Ketorolac | 74103-06-3 | |
Ketorolac tromethamine salt | 74103-07-4 | |
Licofelone | 156897-06-2 | |
Loganin | Cox-1 inhibitor | 18524-94-2 |
Lornoxicam | COX-1/COX-2 inhibitor | 70374-39-9 |
Loxoprofen | 68767-14-6 | |
Lumiracoxib | 220991-20-8 | |
Meclofenamate Sodium | 6385-02-0 | |
Mefenamic Acid | Anti-inflammatory agent | 61-68-7 |
Meloxicam (Mobic) | Nonsteroidal anti-inflammatory drug | 71125-38-7 |
Nabumetone | 42924-53-8 | |
Naproxen Sodium | cyclooxygenase inhibitor | 26159-34-2 |
NCX 4040 | 287118-97-2 | |
NCX 466 | 1262956-64-8 | |
Nepafenac | Anti-inflammatory drug (NSAID) | 78281-72-8 |
Nimesulide | Non-steroidal anti-inflammatory drug | 51803-78-2 |
Oxaprozin | Anti-inflammatory drug | 21256-18-8 |
Parecoxib | 198470-84-7 | |
Parecoxib Sodium | 198470-85-8 | |
Phenacetin | Non-opioid analgesic | 62-44-2 |
Piroxicam | Prostaglandin synthesis/Coxinhibitor | 36322-90-4 |
Rofecoxib | COX-2 inhibitor | 162011-90-7 |
Salicylic acid | 69-72-7 | |
SC 236 | 170569-86-5 | |
SC 560 | COX-1-selective inhibitor | 188817-13-2 |
SC 58125 | 162054-19-5 | |
Sulindac | Anti-inflammatory agent;COX inhibitor | 38194-50-2 |
Tenidap | 120210-48-2 | |
Tolfenamic Acid | Non-steroidal anti-inflammatory drug | 13710-19-5 |
Triflusal | 322-79-2 | |
Valdecoxib | COX-2 inhibitor | 181695-72-7 |
Zaltoprofen | Cyclooxygenase (COX) inhibitor | 74711-43-6 |
Transcripts for PTGS1 Gene
mRNA/cDNA for PTGS1 Gene
- (11) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (156) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTGS1 Gene
- Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PTGS1
- genomics-online: gRNA clones - Search results for 113 available COX1 gene related products
- Overview of 113 available COX1 gene related products
- Applied Biological Materials CRISPR for PTGS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGS1
- GenScript: Design CRISPR guide RNA sequences for PTGS1
miRNA Products
- Search ViGene Biosciences for PTGS1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PTGS1
- Browse OriGene Inhibitory RNA Products For PTGS1
- genomics-online: shRNA clones - Search results for 113 available COX1 gene related products
- Overview of 113 available COX1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGS1 gene
Clone Products
-
OriGene ORF clones in human for PTGS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PTGS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTGS1
- Applied Biological Materials Clones for PTGS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - |
Expression for PTGS1 Gene
mRNA differential expression in normal tissues according to GTEx for PTGS1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGS1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PTGS1 Gene:
PTGS1SOURCE GeneReport for Unigene cluster for PTGS1 Gene:
Hs.201978Evidence on tissue expression from TISSUES for PTGS1 Gene
- Blood(4.6)
- Nervous system(4.6)
- Lung(4.4)
- Skin(3)
- Stomach(2.8)
- Intestine(2.6)
- Kidney(2.5)
- Heart(2.4)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for PTGS1
-
OriGene qPCR primer pairs and template standards for PTGS1
- genomics-online: primer clones - Search results for 113 available COX1 gene related products
- Overview of 113 available COX1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGS1 Gene
Orthologs for PTGS1 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PTGS1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | PTGS1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PTGS1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ptgs1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ptgs1 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | PTGS1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PTGS1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PTGS1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ptgs1 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6116 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ptgs1 33 34 |
|
||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11882 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
CSA.3689 34 |
|
ManyToMany | |||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1052 33 |
|
- Species where no ortholog for PTGS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PTGS1 Gene
(1) SIMAP similar genes for PTGS1 Gene using alignment to 1 proteins:
Variants for PTGS1 Gene
SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10306114 | drug-response, aspirin response - Efficacy | 122,370,243(+) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000008072 | -- | 122,376,477(+) | GG/ | intron_variant | |
rs1000210449 | -- | 122,396,187(+) | T/C | downstream_transcript_variant | |
rs1000495531 | -- | 122,388,494(+) | T/A | intron_variant | |
rs1000514376 | -- | 122,384,766(+) | G/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2417467 | CNV | deletion | 18987734 |
esv3452014 | CNV | insertion | 20981092 |
nsv1115230 | CNV | deletion | 24896259 |
nsv416964 | CNV | deletion | 16902084 |
nsv831716 | CNV | gain | 17160897 |
Additional Variant Information for PTGS1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGS1 Gene
Disorders for PTGS1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
aspirin resistance |
|
|
chronic cystitis |
|
|
gastric ulcer |
|
|
urticaria |
|
|
stomach disease |
|
Additional Disease Information for PTGS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGS1 Gene
Publications for PTGS1 Gene
- Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 22 44 58
- Influence of cyclooxygenase-1 genotype on ex vivo aspirin response in patients at risk for stroke. (PMID: 19390185) Momary KM … Cavallari LH (Cerebrovascular diseases (Basel, Switzerland) 2009) 3 22 44 58
- Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. (PMID: 19350112) Pettinella C … Davì G (Thrombosis and haemostasis 2009) 3 22 44 58
- A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease. (PMID: 19091535) Helmersson J … Basu S (Prostaglandins, leukotrienes, and essential fatty acids 2009) 3 22 44 58
- Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population. (PMID: 18705313) Arisawa T … Nakano H (Hepato-gastroenterology 2008) 3 22 44 58
Products for PTGS1 Gene
- R&D Systems Antibodies for PTGS1 (COX-1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PTGS1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PTGS1
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGS1
- Origene Custom Protein Services for PTGS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGS1
- Browse OriGene Inhibitory RNA Products For PTGS1
- OriGene qPCR primer pairs and template standards for PTGS1
- OriGene qPCR primer pairs for PTGS1
- OriGene CRISPR knockouts for PTGS1
- OriGene ORF clones in human for PTGS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTGS1
- GenScript: Next-day shipping of latest version cDNA ORF clones for PTGS1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PTGS1
- GenScript Custom Assay Services for PTGS1
- GenScript Custom overexpressing Cell Line Services for PTGS1
- GenScript: Design CRISPR guide RNA sequences for PTGS1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PTGS1
- Cell Signaling Technology (CST) Antibodies for PTGS1 (COX-1)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PTGS1
- Novus Biologicals lysates and proteins for PTGS1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for PTGS1
- Abcam proteins for PTGS1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for PTGS1
- Cloud-Clone Corp. Proteins for PTGS1
- Cloud-Clone Corp. Assay Kits for PTGS1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for PTGS1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PTGS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for PTGS1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTGS1
- VectorBuilder custom plasmid, inducible vectors for PTGS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGS1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTGS1
- antibodies-online: Search results for 153 available PTGS1 Antibodies ranked by validation data
- Compare Top PTGS1 Antibodies
- antibodies-online: Search results for 66 available PTGS1 Elisa Kits ranked by validation data
- Compare Top PTGS1 Elisa Kits
- antibodies-online: Search results for 10 available PTGS1 Proteins ranked by validation data
- Compare Top PTGS1 Proteins
- GeneTex PTGS1 antibody for PTGS1
- Search GeneTex for Proteins for PTGS1
- ViGene Biosciences adenoviral particle packaged cDNA for PTGS1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PTGS1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PTGS1 gene
- Search ViGene Biosciences for PTGS1
- Santa Cruz Biotechnology (SCBT) Antibodies for PTGS1
- Search Santa Cruz Biotechnology (SCBT) for PTGS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTGS1
- Horizon Cell Lines for PTGS1
- genomics-online: cdna clones - Search results for 113 available PTGS1 gene related products
- Overview of 113 available PTGS1 gene related products
- orf clones - Search results for 113 available PTGS1 gene related products
- Overview of 113 available PTGS1 gene related products
- genomics-online: gRNA clones - Search results for 113 available PTGS1 gene related products
- Overview of 113 available PTGS1 gene related products
- genomics-online: primer clones - Search results for 113 available PTGS1 gene related products
- Overview of 113 available PTGS1 gene related products
- genomics-online: shRNA clones - Search results for 113 available PTGS1 gene related products
- Overview of 113 available PTGS1 gene related products
Sources for PTGS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew