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PTGS1 Gene

protein-coding   GIFtS: 73
GCID: GC09P125133

Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H...

  See PTGS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase And
Cyclooxygenase)1 2
     PGG/HS2
COX12 3 5     PHS12
Prostaglandin H2 Synthase 12 3     PTGHS2
PGHS-12 3     cyclooxygenase-12
PGH Synthase 12 3     Prostaglandin G/H Synthase 12
EC 1.14.99.13 8     COX-13
COX32 5     Cyclooxygenase-13
PCOX12 5     PHS 13
PGHS12 5     Prostaglandin-Endoperoxide Synthase 13
PES-12     EC 1.14.998

External Ids:    HGNC: 96041   Entrez Gene: 57422   Ensembl: ENSG000000953037   OMIM: 1768055   UniProtKB: P232193   

Export aliases for PTGS1 gene to outside databases

Previous GC identifers: GC09P116237 GC09P116779 GC09P118586 GC09P120509 GC09P122212 GC09P124173 GC09P094748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTGS1 Gene:
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin.
The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal
anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a
peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell
proliferation during tumor progression. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jan 2014)

GeneCards Summary for PTGS1 Gene:
PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)) is a protein-coding gene. Diseases associated with PTGS1 include chronic cystitis, and ureteral obstruction. GO annotations related to this gene include heme binding and dioxygenase activity. An important paralog of this gene is PTGS2.

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Function: May play an important role in regulating or promoting cell proliferation in some normal and
neoplastically transformed cells

summary for PTGS1 Gene:
Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is
expressed in cells in three isoforms: COX-1, COX-2 and COX-3. COX-1 (constitutive) and COX-2 (inducible)
isoforms catalyze the rate-limiting step of prostaglandin production and are the targets of non-steroidal
anti-inflammatory drugs. COX-3 does not appear to be involved in inflammatory processes, but seems to be
involved in pain and fever. COX-3 is thought to be derived through the retention of the highly structured G
+ C-rich intron 1 of the COX-1 gene.

Gene Wiki entry for PTGS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGS1 gene promoter:
         Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGS1 promoter sequence
   Search Chromatin IP Primers for PTGS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32-q33.3   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q32-q33.3

PTGS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGS1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125133:  view genomic region     (about GC identifiers)

Start:
125,132,824 bp from pter      End:
125,157,982 bp from pter
Size:
25,159 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219 (See protein sequence)
Recommended Name: Prostaglandin G/H synthase 1 precursor  
Size: 599 amino acids; 68686 Da
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)
Subunit: Homodimer
Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase
Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin
Sequence caution: Sequence=CAI14716.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K1V7 B4DHQ2 Q15122 Q5T7T6 Q5T7T7 Q5T7T8
Alternative splicing: 3 isoforms:  P23219-1   P23219-2   P23219-3   

Explore the universe of human proteins at neXtProt for PTGS1: NX_P23219

Explore proteomics data for PTGS1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn67, Asn103, Asn143
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PTGS1 (P23219) (see all 24)
     LYHWHPL  GNPICSP  GPGFTKA  DCPTPMG 


    See PTGS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_000953.2  NP_001258093.1  NP_001258094.1  NP_001258095.1  NP_001258296.1  NP_001258297.1  NP_542158.1  

    ENSEMBL proteins: 
     ENSP00000223423   ENSP00000354612   ENSP00000411606   ENSP00000437709   ENSP00000362802  
    Reactome Protein details: P23219

    PTGS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PTGS1
    OriGene Protein Over-expression Lysate for PTGS1
    OriGene MassSpec for PTGS1
    OriGene Custom Protein Services for PTGS1
    GenScript Custom Purified and Recombinant Proteins Services for PTGS1
    Novus Biologicals PTGS1 Proteins
    Novus Biologicals PTGS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGS1

     
    Search eBioscience for Proteins for PTGS1 

     
    antibodies-online proteins for PTGS1 (10 products) 

     
    antibodies-online peptides for PTGS1

    PTGS1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGS1
    R&D Systems Antibodies for PTGS1 (COX-1)
    Cell Signaling Technology (CST) Antibodies for PTGS1  (COX-1)
    OriGene Antibodies for PTGS1
    OriGene Custom Antibody Services for PTGS1
    Novus Biologicals PTGS1 Antibodies
    Abcam antibodies for PTGS1
    Cloud-Clone Corp. Antibodies for PTGS1
    ThermoFisher Antibody for PTGS1
    antibodies-online antibodies for PTGS1 (28 products) 

    PTGS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTGS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTGS1
    Enzo Life Sciences assays for PTGS1
    Cloud-Clone Corp. ELISAs for PTGS1
    Cloud-Clone Corp. CLIAs for PTGS1
    Search eBioscience for ELISAs for PTGS1 
    antibodies-online kits for PTGS1 (42 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: COX-1
    Cyclooxygenase

    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR010255 Haem_peroxidase
     IPR019791 Haem_peroxidase_animal_subgr
     IPR002007 Haem_peroxidase_animal

    Graphical View of Domain Structure for InterPro Entry P23219

    ProtoNet protein and cluster: P23219

    3 Blocks protein domains:
    IPB002007 Animal haem peroxidase signature
    IPB006210 Type I EGF
    IPB010255 Haem peroxidase


    UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
    Similarity: Belongs to the prostaglandin G/H synthase family
    Similarity: Contains 1 EGF-like domain


    Find genes that share domains with PTGS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGH1_HUMAN, P23219
    Function: May play an important role in regulating or promoting cell proliferation in some normal and
    neoplastically transformed cells
    Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O

         Genatlas biochemistry entry for PTGS1:
    prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a
    dioxygenase,then as a peroxidase (lipocalin family,Kernel group),monomer,potent mediator of inflammation

         Enzyme Numbers (IUBMB): EC 1.14.99.11 2 EC 1.14.992

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity TAS--
    GO:0004666prostaglandin-endoperoxide synthase activity TAS--
    GO:0005515protein binding ----
    GO:0020037heme binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PTGS1           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptgs1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  other  renal/urinary system 

    Find genes that share phenotypes with PTGS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTGS1: Ptgs1tm1Unc Ptgs1tm1Fun

       genOway: Develop your customized and physiologically relevant rodent model for PTGS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTGS1:
    hsa-mir-18a-3p (MIRT040875), hsa-mir-124-3p (MIRT023020)

    Block miRNA regulation of human, mouse, rat PTGS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTGS1 (see all 29):
    hsa-miR-4291 hsa-miR-4311 hsa-miR-875-3p hsa-miR-16-2* hsa-miR-148b hsa-miR-4305 hsa-miR-578 hsa-miR-3154
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTGS1
    Predesigned siRNA for gene silencing in human, mouse, rat PTGS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTGS1

    Clone
    Products:
         
    OriGene clones in human, mouse for PTGS1 (see all 11)
    OriGene ORF clones in mouse, rat for PTGS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PTGS1 (NM_080591)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGS1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTGS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PTGS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGH1_HUMAN, P23219: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    extracellular2
    mitochondrion2
    cytosol1
    golgi apparatus1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IEA--
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle ISS--

    Find genes that share ontologies with PTGS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTGS1 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.00
    Arachidonic acid metabolism0.40
    C20 prostanoid biosynthesis0.00
    HETE and HPETE biosynthesis and metabolism0.33
    COX reactions0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    4Biological oxidations
    Biological oxidations0.56
    5PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46


    Find genes that share SuperPaths with PTGS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTGS1
        Endothelin-1 Signaling Pathway

    2 Cell Signaling Technology (CST) Pathways for PTGS1
        Neuroscience
    NF-kappaB Signaling

    4 GeneGo (Thomson Reuters) Pathways for PTGS1
        HETE and HPETE biosynthesis and metabolism
    Development VEGF signaling via VEGFR2 - generic cascades
    Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing

    4 BioSystems Pathways for PTGS1
        Eicosanoid Synthesis
    Selenium Pathway
    Prostaglandin Synthesis and Regulation
    C20 prostanoid biosynthesis

    2 Reactome Pathways for PTGS1
        COX reactions
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

    4 PharmGKB Pathways for PTGS1
        Acetaminophen Pathway, Pharmacokinetics
    Celecoxib Pathway, Pharmacodynamics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for PTGS1):
        Arachidonic acid metabolism
    Metabolic pathways
    Serotonergic synapse

    UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
    Pathway: Lipid metabolism; prostaglandin biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTGS1 (see all 6): 

              Hypertension in human mouse rat
              Atherosclerosis in human mouse rat
              Oxidative Stress in human mouse rat
              Prostate Cancer in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTGS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTGS1 (P232192, 3 ENSP000003546124) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUCB1Q028183, ENSP000002632734I2D: score=3 STRING: ENSP00000263273
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15ENSP000002937614STRING: ENSP00000293761
    ALOX15BENSP000003695304STRING: ENSP00000369530
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process ISS--
    GO:0006629lipid metabolic process NAS1907252
    GO:0006693prostaglandin metabolic process ----
    GO:0006805xenobiotic metabolic process TAS--
    GO:0006979response to oxidative stress IEA--

    Find genes that share ontologies with PTGS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PTGS1
      Browse compounds at ApexBio 

    Compounds for PTGS1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CelecoxibSelective cyclooxygenase-2 (COX-2) inhibitor[169590-42-5]
    ResveratrolCyclooxygenase inhibitor[501-36-0]
    NS 398Cyclooxygenase-2 (COX-2) inhibitor[123653-11-2]
    SC 58125Selective cyclooxygenase-2 (COX-2) inhibitor[162054-19-5]
    IndomethacinCyclooxygenase inhibitor (COX-1 > COX-2)[53-86-1]

    Selected HMDB Compounds for PTGS1 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    11R-HEPE11(R)-hydroxyeicosa-5Z,8Z,12E,14Z,17Z-pentaenoate (see all 2)----
    Acetaminophen4'-Hydroxyacetanilide (see all 629)103-90-2--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Aspirin2-(Acetyloxy)benzoic acid (see all 59)50-78-2--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Ibuprofenalpha-(4-Isobutylphenyl)propionate (see all 9)15687-27-1--
    IronArmco iron (see all 19)7439-89-6--
    Naproxen(+)-(S)-Naproxen (see all 49)22204-53-1--
    OxygenOxygen (see all 5)7782-44-7--
    Prostaglandin G1PGG(,1) (see all 6)----

    Selected DrugBank Compounds for PTGS1 (see all 102)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IbuprofenIbuprophen (see all 3)15687-27-1target--14741265 11752352 14987823 12852704 23536207 15575422 14592549
    enzymeinhibitor14741265 11752352 14987823 12852704 23536207 15575422 14592549 22668799
    DiclofenacDiclofenac Acid (see all 4)15307-86-5targetinhibitor12534640 12713596 11752352 12852704 12966366 12414874
    enzymesubstrate12534640 12713596 11752352 12852704 12966366 12414874 19515014
    FlurbiprofenFLP (see all 5)5104-49-4targetinhibitor12711844 19066416 11811354 17562170 10358065 10773011 12392782
    IcosapentEicosapentaenoic acid (see all 4)10417-94-4targetinhibitor15990700 12562875 14993240 20463020 16141635 16190133 11477109
    Salicyclic acid2-Carboxyphenol (see all 10)69-72-7targetinhibitor5284360 15840771 14746879 11752352 15035793 16368818 15871445
    Salicylate-sodium-- --targetinhibitor5284360 15840771 14746879 11752352 15035793 16368818 15871445
    Acetylsalicylic acid2-Acetoxybenzenecarboxylic acid (see all 24)50-78-2targetinhibitor17131625 11752352 17030227 17319904 17078596 17259075
    gamma-Homolinolenic acid(Z,Z,Z)-8,11,14-Eicosatrienoic acid (see all 6)1783-84-2targetinhibitor15990700 11121413 11752352 11939906 11477109 16190133
    BalsalazideBalsalazida [Spanish] (see all 4)80573-04-2targetinhibitor17139284 11752352 17016423 19743890 12950415
    Etodolac-- 41340-25-4targetinhibitor15198222 16473424 9146894 8566109 12358053

    2 IUPHAR Ligands for PTGS1 (COX-1 )    About this table
    LigandTypeActionAffinityPubmed IDs
    FR122047
    InhibitorInhibition7.510720634
    valerylsalicylate
    InhibitorInhibition7.57872783

    Selected Novoseek inferred chemical compound relationships for PTGS1 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin 91 300 9461646 (4), 15035793 (3), 10609518 (2), 7947975 (2) (see all 99)
    pge2 90.6 411 11809691 (4), 8872612 (3), 15963707 (3), 9779823 (3) (see all 99)
    celecoxib 89.5 89 12152003 (2), 16952493 (2), 10664917 (2), 15498669 (2) (see all 62)
    arachidonic acid 89.5 273 10358065 (5), 7737984 (4), 10551587 (3), 10206978 (3) (see all 99)
    rofecoxib 89.5 72 10096266 (3), 11028250 (3), 11136272 (2), 10411562 (2) (see all 48)
    aspirin 84.6 396 11717412 (5), 18753249 (5), 15041270 (4), 19152549 (4) (see all 99)
    meloxicam 83.5 52 10381787 (3), 10812057 (3), 11874389 (3), 10340919 (2) (see all 32)
    ns 398 82.8 16 10217458 (2), 9875720 (1), 11563332 (1), 16964399 (1) (see all 15)
    prostaglandin-h2 82.3 34 17878511 (2), 8652509 (1), 10734173 (1), 11081405 (1) (see all 20)
    valdecoxib 81.9 6 12644588 (1), 15494548 (1), 16519515 (1), 12466002 (1) (see all 5)

    2 PharmGKB related drug/compound annotations for PTGS1 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  
    clopidogrelCA  



    Find genes that share compounds with PTGS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTGS1 gene (7 alternative transcripts): 
    NM_000962.3  NM_001271164.1  NM_001271165.1  NM_001271166.1  NM_001271367.1  NM_001271368.1  NM_080591.2  

    Unigene Cluster for PTGS1:

    Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
    Hs.201978  [show with all ESTs]
    Unigene Representative Sequence: NM_001271368
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223423 ENST00000362012(uc011lys.1 uc010mwb.1 uc004bmg.1 uc004bmf.1 uc004bmh.1 uc011lyt.1)
    ENST00000426608 ENST00000540753 ENST00000373698
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    Additional mRNA sequence: 

    AF086438.1 AF129755.1 AJ420464.1 AK290022.1 AK295221.1 AK304403.1 AK308222.1 BC029840.1 
    DQ180740.1 DQ180741.1 DQ180742.1 M59979.1 S36219.1 S36271.1 S78220.1 U63846.1 

    12 DOTS entries:

    DT.446317  DT.100767562  DT.121193472  DT.101957346  DT.100767557  DT.101982936  DT.121193484  DT.75197219 
    DT.100767561  DT.100767556  DT.97797260  DT.91965381 

    Selected AceView cDNA sequences (see all 156):

    S36219 BF064148 AL556508 AA345128 AI076274 CD014048 BC029840 AI202433 
    AU279462 AL709654 N54739 BF477437 NM_080591 NM_000962 AA635841 AA707736 
    BF718263 AI567867 BM679302 AA630760 BQ014239 BM990424 S78220 BU733396 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTGS1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
    SP1:                                                                                                                                    
    SP2:                                -     -                                                                                             
    SP3:                                -     -     -                                                     -                                 
    SP4:                                -     -                       -                                                                     
    SP5:                                -     -                                                                                             


    ECgene alternative splicing isoforms for PTGS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PTGS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTAATAA
    PTGS1 Expression
    About this image


    PTGS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
             Floor plate-like cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
             Human umbilical vein endothelial cells (HUVEC)
    PTGS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTGS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.201978
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTGS1 (see all 6): 
              Hypertension in human mouse rat
              Atherosclerosis in human mouse rat
              Oxidative Stress in human mouse rat
              Prostate Cancer in human mouse rat
              Angiogenesis in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for PTGS1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgs11 , 5 prostaglandin-endoperoxide synthase 11, 5 85.76(n)1
    89.93(a)1
      2 (24.19 cM)5
    192241  NM_008969.31  NP_032995.11 
     362304265 
    chicken
    (Gallus gallus)
    Aves PTGS11 prostaglandin-endoperoxide synthase 1 (prostaglandin more 75.97(n)
    78.18(a)
      427752  XM_425326.4  XP_425326.4 
    lizard
    (Anolis carolinensis)
    Reptilia PTGS16
    prostaglandin-endoperoxide synthase 1 (prostagland...
    69(a)
    1 ↔ 1
    GL344642.1(2752-17411)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61162 Xenopus laevis transcribed sequence with moderate similarity more 72.97(n)    48053286 
    zebrafish
    (Danio rerio)
    Actinopterygii ptgs12 prostaglandin-endoperoxide synthase 1 76.12(n)   246226  AY028584.1 


    ENSEMBL Gene Tree for PTGS1 (if available)
    TreeFam Gene Tree for PTGS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTGS1 gene
    PTGS22  
    1 SIMAP similar gene for PTGS1 using alignment to 1 protein entry:     PGH1_HUMAN:
    PTGS2

    Find genes that share paralogs with PTGS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTGS1 (see all 1061)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112889011,2
    C--125135103(+) TTTTT-/TATCCC 6 -- int10--------
    rs103061441,2
    C,F--125142092(+) TTTTTT/-CCTGC 7 -- int12Minor allele frequency- -:0.05NS 82
    rs1392465691,2
    --125142647(+) GCACTA/GCTGTG 2 -- us2k10--------
    rs727697241,2
    C--125142650(+) CTGCTA/GTGGCC 2 -- us2k10--------
    rs713719401,2
    C--125142747(+) AAATA-/AATA  
            
    GGTTG
    7 -- int11Minor allele frequency- AATA:0.00NA 2
    rs354825611,2
    C,F--125142750(+) GCCCTA/GTAAGT 2 -- us2k13Minor allele frequency- G:0.10CSA WA NA 239
    rs1442849301,2
    C--125142791(+) TGACAC/GCAGTC 2 -- us2k10--------
    rs1487548851,2
    C--125142907(+) TGTGTA/CTCCAG 2 -- us2k10--------
    rs1820831341,2
    --125143179(+) TCTACC/GTTCTC 6 -- us2k10--------
    rs1866941791,2
    --125143222(+) TGGAGA/GGCTGC 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTGS1 (125132824 - 125157982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTGS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2417467CNV Deletion18987734
    nsv416964CNV Loss16902084
    nsv831716CNV Gain17160897

    Human Gene Mutation Database (HGMD): PTGS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGS1
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176805    OMIM disorders: --

    8 diseases for PTGS1:    
    About MalaCards
    chronic cystitis    ureteral obstruction    cystitis    urticaria
    gastric ulcer    morphine dependence    viral encephalitis    ovarian epithelial cancer

    2 diseases from the University of Copenhagen DISEASES database for PTGS1:
    Vascular disease     Arthritis

    Find genes that share disorders with PTGS1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PTGS1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 71.7 163 16982919 (3), 10628589 (2), 12733982 (2), 17270500 (2) (see all 99)
    osteoarthritis 61.6 22 15337183 (2), 11041909 (2), 10719816 (1), 14752171 (1) (see all 16)
    gastrointestinal complications 58.1 3 10377455 (1), 14602052 (1)
    colon cancer 57 18 19258012 (4), 16091009 (2), 7780968 (2), 16984374 (2) (see all 12)
    intestinal polyps 53.6 5 12941808 (3), 16984374 (1)
    ulcer 53.2 28 16247187 (3), 11519793 (2), 17926541 (2), 11136275 (2) (see all 15)
    nasal polyps 52.1 29 16517580 (4), 15921208 (4), 15480320 (2), 19132974 (2) (see all 11)
    rheumatoid arthritis 51.8 11 10719816 (2), 15167967 (1), 10390126 (1), 10812057 (1) (see all 9)
    polyps 50 31 12941808 (4), 11584208 (2), 11495083 (2), 19251796 (1) (see all 11)
    arthritis 50 13 11550975 (2), 10193996 (1), 9714356 (1), 10225538 (1) (see all 10)

    Genetic Association Database (GAD): PTGS1
    Human Genome Epidemiology (HuGE) Navigator: PTGS1 (70 documents)

    Export disorders for PTGS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTGS1 gene, integrated from 10 sources (see all 1612):
    (articles sorted by number of sources associating them with PTGS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. (PubMed id 1907252)1, 2, 3 Funk C.D.... Fitzgerald G.A. (FASEB J. 1991)
    2. Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. (PubMed id 2512924)1, 2, 3 Yokoyama C. and Tanabe T. (Biochem. Biophys. Res. Commun. 1989)
    3. A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease. (PubMed id 19091535)1, 4, 9 Helmersson J....Basu S. (Prostaglandins Leukot. Essent. Fatty Acids 2009)
    4. Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population. (PubMed id 18705313)1, 4, 9 Arisawa T....Nakano H. (Hepatogastroenterology 2008)
    5. COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population. (PubMed id 18214026)1, 4, 9 Hou L....Chow W.H. (Anticancer Res. 2007)
    6. Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke. (PubMed id 15041270)1, 4, 9 Hillarp A....Mattiasson I. (Thromb. Res. 2003)
    7. Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. (PubMed id 12192304)1, 2, 9 Scott B.T.... Long G.L. (Blood Coagul. Fibrinolysis 2002)
    8. Genetic polymorphisms of cyclooxygenase-1 (COX-1) are associated with functional dyspepsia in Japanese women. (PubMed id 18582172)1, 4, 9 Arisawa T....Nakano H. (J Womens Health (Larchmt) 2008)
    9. Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. (PubMed id 17640058)1, 4, 9 Hubner R.A....Houlston R.S. (Int. J. Cancer 2007)
    10. Cyclooxygenase-1 gene polymorphisms in patients with different asthma phenotypes and atopy. (PubMed id 16055872)1, 4, 9 Shi J....Kedda M.A. (Eur. Respir. J. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5742 HGNC: 9604 AceView: PTGS1 Ensembl:ENSG00000095303 euGenes: HUgn5742
    ECgene: PTGS1 Kegg: 5742 H-InvDB: PTGS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PTGS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTGS1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ptgs1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTGS1 gene:
    Search GeneIP for patents involving PTGS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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