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Aliases for PTGR2 Gene

Aliases for PTGR2 Gene

  • Prostaglandin Reductase 2 2 3 5
  • Zinc-Binding Alcohol Dehydrogenase Domain-Containing Protein 1 3 4
  • 15-Oxoprostaglandin 13-Reductase 3 4
  • EC 1.3.1.48 4 63
  • PRG-2 3 4
  • ZADH1 3 4
  • Zinc Binding Alcohol Dehydrogenase, Domain Containing 1 3
  • Zinc Binding Alcohol Dehydrogenase Domain Containing 1 2
  • 15-Oxoprostaglandin-Delta13-Reductase 3
  • Epididymis Secretory Protein Li 298 3
  • HEL-S-298 3
  • PGR2 3

External Ids for PTGR2 Gene

Previous HGNC Symbols for PTGR2 Gene

  • ZADH1

Previous GeneCards Identifiers for PTGR2 Gene

  • GC14P073389
  • GC14P074318
  • GC14P054485

Summaries for PTGR2 Gene

Entrez Gene Summary for PTGR2 Gene

  • This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for PTGR2 Gene

PTGR2 (Prostaglandin Reductase 2) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and 15-oxoprostaglandin 13-oxidase activity. An important paralog of this gene is ENSG00000258653.

UniProtKB/Swiss-Prot for PTGR2 Gene

  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGR2 Gene

Genomics for PTGR2 Gene

Regulatory Elements for PTGR2 Gene

Promoters for PTGR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTGR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGR2 Gene

Chromosome:
14
Start:
73,851,831 bp from pter
End:
73,886,827 bp from pter
Size:
34,997 bases
Orientation:
Plus strand

Genomic View for PTGR2 Gene

Genes around PTGR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGR2 Gene

Proteins for PTGR2 Gene

  • Protein details for PTGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8N7-PTGR2_HUMAN
    Recommended name:
    Prostaglandin reductase 2
    Protein Accession:
    Q8N8N7
    Secondary Accessions:
    • Q3L8A4
    • Q6MZH8

    Protein attributes for PTGR2 Gene

    Size:
    351 amino acids
    Molecular mass:
    38499 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for PTGR2 Gene

    Alternative splice isoforms for PTGR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGR2 Gene

Proteomics data for PTGR2 Gene at MOPED

Post-translational modifications for PTGR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGR2 Gene

Antibody Products

Domains & Families for PTGR2 Gene

Protein Domains for PTGR2 Gene

Suggested Antigen Peptide Sequences for PTGR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8N7

UniProtKB/Swiss-Prot:

PTGR2_HUMAN :
  • Belongs to the NADP-dependent oxidoreductase L4BD family.
Family:
  • Belongs to the NADP-dependent oxidoreductase L4BD family.
genes like me logo Genes that share domains with PTGR2: view

No data available for Gene Families for PTGR2 Gene

Function for PTGR2 Gene

Molecular function for PTGR2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11.21 uM for 15-keto-PGE2 {ECO:0000269 PubMed:19000823}; KM=15.87 uM for NADPH {ECO:0000269 PubMed:19000823}; Vmax=159 nmol/min/mg enzyme for 15-keto-PGE2 {ECO:0000269 PubMed:19000823}; Vmax=67 nmol/min/mg enzyme for NADPH {ECO:0000269 PubMed:19000823};
UniProtKB/Swiss-Prot CatalyticActivity:
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).

Enzyme Numbers (IUBMB) for PTGR2 Gene

Gene Ontology (GO) - Molecular Function for PTGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047522 15-oxoprostaglandin 13-oxidase activity IDA 19000823
genes like me logo Genes that share ontologies with PTGR2: view
genes like me logo Genes that share phenotypes with PTGR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGR2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTGR2 Gene

Localization for PTGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGR2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGR2 Gene COMPARTMENTS Subcellular localization image for PTGR2 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PTGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PTGR2: view

Pathways & Interactions for PTGR2 Gene

SuperPathways for PTGR2 Gene

No Data Available

Interacting Proteins for PTGR2 Gene

Gene Ontology (GO) - Biological Process for PTGR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PTGR2 Gene

Drugs & Compounds for PTGR2 Gene

(3) Drugs for PTGR2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Indomethacin Approved, Investigational Pharma Partial agonist, Agonist, Target, inhibitor Cox inhibitor 106
(5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID Experimental Pharma Target 0
NAD Pharma Full agonist, Agonist 0

(2) Additional Compounds for PTGR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with PTGR2: view

Transcripts for PTGR2 Gene

Unigene Clusters for PTGR2 Gene

Prostaglandin reductase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGR2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: - - - -
SP4: -
SP5: - - - - -

Relevant External Links for PTGR2 Gene

GeneLoc Exon Structure for
PTGR2
ECgene alternative splicing isoforms for
PTGR2

Expression for PTGR2 Gene

mRNA expression in normal human tissues for PTGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTGR2 Gene

This gene is overexpressed in Skin (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGR2 Gene



SOURCE GeneReport for Unigene cluster for PTGR2 Gene Hs.632344

mRNA Expression by UniProt/SwissProt for PTGR2 Gene

Q8N8N7-PTGR2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PTGR2: view

Protein tissue co-expression partners for PTGR2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PTGR2 Gene

Orthologs for PTGR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTGR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGR2 35
  • 91.36 (n)
  • 91.17 (a)
PTGR2 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PTGR2 35
  • 92.12 (n)
  • 91.74 (a)
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ptgr2 35
  • 85 (n)
  • 86.61 (a)
Ptgr2 16
Ptgr2 36
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PTGR2 35
  • 99.91 (n)
  • 100 (a)
PTGR2 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ptgr2 35
  • 84.15 (n)
  • 84.51 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTGR2 35
  • 74.83 (n)
  • 76.95 (a)
PTGR2 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgr2 35
  • 68.3 (n)
  • 68.3 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18312 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-119a7.6 35
  • 63.77 (n)
  • 64.93 (a)
PTGR2 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M106.3 35
  • 52.96 (n)
  • 47.04 (a)
M106.3 36
  • 42 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL360W 35
  • 42.17 (n)
  • 27.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML131W 35
  • 43 (n)
  • 26.71 (a)
-- 36
  • 20 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02299 35
  • 47.13 (n)
  • 38.22 (a)
Species with no ortholog for PTGR2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTGR2 Gene

ENSEMBL:
Gene Tree for PTGR2 (if available)
TreeFam:
Gene Tree for PTGR2 (if available)

Paralogs for PTGR2 Gene

Paralogs for PTGR2 Gene

(1) SIMAP similar genes for PTGR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTGR2: view

Variants for PTGR2 Gene

Sequence variations from dbSNP and Humsavar for PTGR2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs15799 -- 73,884,406(-) TCAAG(C/T)GTTCT utr-variant-3-prime
rs1029715 -- 73,872,079(-) AGGAC(A/C/G)ACAGC intron-variant
rs1962795 -- 73,858,548(-) AAAGA(C/T)GGAGT intron-variant
rs1963799 -- 73,876,109(-) GGGTG(C/T)GGTGG intron-variant
rs1968102 -- 73,870,377(-) CATGG(A/C)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGR2 Gene

Variant ID Type Subtype PubMed ID
esv2660789 CNV Deletion 23128226

Variation tolerance for PTGR2 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGR2 Gene

HapMap Linkage Disequilibrium report
PTGR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGR2 Gene

Disorders for PTGR2 Gene

Relevant External Links for PTGR2

Genetic Association Database (GAD)
PTGR2
Human Genome Epidemiology (HuGE) Navigator
PTGR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGR2

No disorders were found for PTGR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGR2 Gene

Publications for PTGR2 Gene

  1. Cloning and characterization of a novel splicing variant of the ZADH1 gene. (PMID: 15004468) Zhang L. … Huo K. (Cytogenet. Genome Res. 2003) 3 4 23 67
  2. Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. (PMID: 19000823) Wu Y.H. … Wang A.H. (Structure 2008) 3 25
  3. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. (PMID: 17449869) Chou W.L. … Chang Z.F. (J. Biol. Chem. 2007) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for PTGR2 Gene

Sources for PTGR2 Gene

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