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Aliases for PTGR1 Gene

Aliases for PTGR1 Gene

  • Prostaglandin Reductase 1 2 3
  • LTB4DH 3 4 6
  • Zinc Binding Alcohol Dehydrogenase Domain Containing 3 2 3
  • NADP-Dependent Leukotriene B4 12-Hydroxydehydrogenase 3 4
  • Leukotriene B4 12-Hydroxydehydrogenase 2 3
  • 15-Oxoprostaglandin 13-Reductase 3 4
  • PRG-1 3 4
  • EC 1.3.1.48 4
  • EC 1.3.1.74 4
  • EC 1.3.1.- 4
  • ZADH3 3
  • PGR1 3

External Ids for PTGR1 Gene

Previous Symbols for PTGR1 Gene

  • LTB4DH

Summaries for PTGR1 Gene

Entrez Gene Summary for PTGR1 Gene

  • This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for PTGR1 Gene

PTGR1 (Prostaglandin Reductase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity and 15-oxoprostaglandin 13-oxidase activity. An important paralog of this gene is ENSG00000258653.

UniProtKB/Swiss-Prot for PTGR1 Gene

  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGR1 Gene

Genomics for PTGR1 Gene

Genomic Location for PTGR1 Gene

Start:
111,549,722 bp from pter
End:
111,599,855 bp from pter
Size:
50,134 bases
Orientation:
Minus strand

Genomic View for PTGR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGR1 Gene

Regulatory Elements for PTGR1 Gene

Proteins for PTGR1 Gene

  • Protein details for PTGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14914-PTGR1_HUMAN
    Recommended name:
    Prostaglandin reductase 1
    Protein Accession:
    Q14914
    Secondary Accessions:
    • A8K0N2
    • B4DPK3
    • F5GY50
    • Q8IYQ0
    • Q9H1X6

    Protein attributes for PTGR1 Gene

    Size:
    329 amino acids
    Molecular mass:
    35870 Da
    Quaternary structure:
    • Monomer or homodimer.

    Three dimensional structures from OCA and Proteopedia for PTGR1 Gene

    Alternative splice isoforms for PTGR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGR1 Gene

Proteomics data for PTGR1 Gene at MOPED

Post-translational modifications for PTGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGR1 Gene

No data available for DME Specific Peptides for PTGR1 Gene

Domains for PTGR1 Gene

Protein Domains for PTGR1 Gene

UniProtKB/Swiss-Prot:

PTGR1_HUMAN
Family:
  • Belongs to the NADP-dependent oxidoreductase L4BD family.:
    • Q14914
genes like me logo Genes that share domains with PTGR1: view

No data available for Gene Families for PTGR1 Gene

Function for PTGR1 Gene

Molecular function for PTGR1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H
UniProtKB/Swiss-Prot CatalyticActivity: 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
UniProtKB/Swiss-Prot Function: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.

Enzyme Numbers (IUBMB) for PTGR1 Gene

Gene Ontology (GO) - Molecular Function for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0032440 2-alkenal reductase [NAD(P)] activity IEA --
GO:0036132 13-prostaglandin reductase activity IEA --
genes like me logo Genes that share ontologies with PTGR1: view

Phenotypes for PTGR1 Gene

GenomeRNAi human phenotypes for PTGR1:
genes like me logo Genes that share phenotypes with PTGR1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PTGR1 Gene

Localization for PTGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGR1 Gene COMPARTMENTS Subcellular localization image for PTGR1 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PTGR1: view

Pathways for PTGR1 Gene

genes like me logo Genes that share pathways with PTGR1: view

Pathways by source for PTGR1 Gene

Gene Ontology (GO) - Biological Process for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process TAS --
GO:0009636 response to toxic substance IEA --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019371 cyclooxygenase pathway TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PTGR1: view

Compounds for PTGR1 Gene

(3) HMDB Compounds for PTGR1 Gene

Compound Synonyms Cas Number PubMed IDs
(5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate
  • (5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoic acid
Not Available
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8

(3) Drugbank Compounds for PTGR1 Gene

(2) Novoseek inferred chemical compound relationships for PTGR1 Gene

Compound -log(P) Hits PubMed IDs
12-oxo-ltb4 98.9 1
leukotriene b4 81.8 10
genes like me logo Genes that share compounds with PTGR1: view

Transcripts for PTGR1 Gene

Unigene Clusters for PTGR1 Gene

Prostaglandin reductase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:

Relevant External Links for PTGR1 Gene

GeneLoc Exon Structure for
PTGR1
ECgene alternative splicing isoforms for
PTGR1

Expression for PTGR1 Gene

mRNA expression in normal human tissues for PTGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGR1 Gene

This gene is overexpressed in Liver (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGR1 Gene

SOURCE GeneReport for Unigene cluster for PTGR1 Gene Hs.584864

mRNA Expression by UniProt/SwissProt for PTGR1 Gene

Q14914-PTGR1_HUMAN
Tissue specificity: High expression in the kidney, liver, and intestine but not in leukocytes.
genes like me logo Genes that share expressions with PTGR1: view

Orthologs for PTGR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTGR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGR1 36
  • 99.49 (n)
  • 99.09 (a)
PTGR1 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGR1 36
  • 84.6 (n)
  • 80.24 (a)
PTGR1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGR1 36
  • 88.55 (n)
  • 86.32 (a)
PTGR1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgr1 36
  • 83.18 (n)
  • 80.55 (a)
Ptgr1 16
Ptgr1 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGR1 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGR1 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgr1 36
  • 82.98 (n)
  • 81.76 (a)
chicken
(Gallus gallus)
Aves PTGR1 36
  • 67.58 (n)
  • 64.22 (a)
PTGR1 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGR1 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23763 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485344 36
  • 64.23 (n)
  • 61.89 (a)
Str.10740 36
zebrafish
(Danio rerio)
Actinopterygii Dr.880 36
ptgr1 36
  • 62.08 (n)
  • 60.86 (a)
ptgr1 37
  • 60 (a)
OneToMany
PTGR1 (2 of 2) 37
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000288 36
  • 52.75 (n)
  • 49.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 24 (a)
OneToMany
-- 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03080 36
  • 49.17 (n)
  • 42.86 (a)
rice
(Oryza sativa)
Liliopsida Os04g0497000 36
  • 47.59 (n)
  • 43.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09040 36
  • 47.6 (n)
  • 37.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPB24D3.08c 36
  • 47.43 (n)
  • 39.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
CSA.4563 37
  • 45 (a)
OneToMany
Species with no ortholog for PTGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGR1 Gene

ENSEMBL:
Gene Tree for PTGR1 (if available)
TreeFam:
Gene Tree for PTGR1 (if available)

Paralogs for PTGR1 Gene

Paralogs for PTGR1 Gene

Selected SIMAP similar genes for PTGR1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PTGR1 Gene

genes like me logo Genes that share paralogs with PTGR1: view

Variants for PTGR1 Gene

Sequence variations from dbSNP and Humsavar for PTGR1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs767402 -- 111,581,503(+) CACCT(A/C)AAAGA intron-variant
rs1053959 - 111,597,344(-) AGACA(G/T)CTGAG reference, missense, nc-transcript-variant
rs1053968 -- 111,590,312(-) CTGTT(C/T)ATCAT intron-variant
rs2273786 -- 111,586,233(+) AGGAT(A/G)CTGTG intron-variant
rs2273787 -- 111,586,284(+) CAACT(A/G)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGR1 Gene

Variant ID Type Subtype PubMed ID
nsv893724 CNV Gain 21882294
esv2678607 CNV Deletion 23128226
esv4254 CNV Deletion 18987735
esv2738936 CNV Deletion 23290073
esv2665450 CNV Deletion 23128226
esv5602 CNV Loss 19470904
dgv1372e199 CNV Deletion 23128226
esv275316 CNV Gain+Loss 21479260

Relevant External Links for PTGR1 Gene

HapMap Linkage Disequilibrium report
PTGR1

Disorders for PTGR1 Gene

Relevant External Links for PTGR1

Genetic Association Database (GAD)
PTGR1
Human Genome Epidemiology (HuGE) Navigator
PTGR1
genes like me logo Genes that share disorders with PTGR1: view

No data available for UniProtKB/Swiss-Prot for PTGR1 Gene

Publications for PTGR1 Gene

  1. cDNA cloning, expression, and mutagenesis study of leukotriene B4 12- hydroxydehydrogenase. (PMID: 8576264) Yokomizo T. … Shimizu T. (J. Biol. Chem. 1996) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. (PMID: 17449869) Chou W.L. … Chang Z.F. (J. Biol. Chem. 2007) 2 3

Products for PTGR1 Gene

Sources for PTGR1 Gene

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