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Aliases for PTGR1 Gene

Aliases for PTGR1 Gene

  • Prostaglandin Reductase 1 2 3 5
  • Zinc Binding Alcohol Dehydrogenase Domain Containing 3 2 3
  • NADP-Dependent Leukotriene B4 12-Hydroxydehydrogenase 3 4
  • Leukotriene B4 12-Hydroxydehydrogenase 2 3
  • 15-Oxoprostaglandin 13-Reductase 3 4
  • LTB4DH 3 4
  • PRG-1 3 4
  • EC 1.3.1.48 4
  • EC 1.3.1.74 4
  • EC 1.3.1.- 4
  • ZADH3 3
  • PGR1 3

External Ids for PTGR1 Gene

Previous HGNC Symbols for PTGR1 Gene

  • LTB4DH

Previous GeneCards Identifiers for PTGR1 Gene

  • GC09M113365
  • GC09M114324
  • GC09M083911

Summaries for PTGR1 Gene

Entrez Gene Summary for PTGR1 Gene

  • This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for PTGR1 Gene

PTGR1 (Prostaglandin Reductase 1) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Prostaglandin 2 biosynthesis and metabolism FM. GO annotations related to this gene include oxidoreductase activity and 13-prostaglandin reductase activity. An important paralog of this gene is ENSG00000283263.

UniProtKB/Swiss-Prot for PTGR1 Gene

  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGR1 Gene

Genomics for PTGR1 Gene

Regulatory Elements for PTGR1 Gene

Enhancers for PTGR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PTGR1 on UCSC Golden Path with GeneCards custom track

Promoters for PTGR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PTGR1 Gene

Chromosome:
9
Start:
111,549,722 bp from pter
End:
111,599,855 bp from pter
Size:
50,134 bases
Orientation:
Minus strand

Genomic View for PTGR1 Gene

Genes around PTGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGR1 Gene

Proteins for PTGR1 Gene

  • Protein details for PTGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14914-PTGR1_HUMAN
    Recommended name:
    Prostaglandin reductase 1
    Protein Accession:
    Q14914
    Secondary Accessions:
    • A8K0N2
    • B4DPK3
    • F5GY50
    • Q8IYQ0
    • Q9H1X6

    Protein attributes for PTGR1 Gene

    Size:
    329 amino acids
    Molecular mass:
    35870 Da
    Quaternary structure:
    • Monomer or homodimer.
    • Monomer or homodimer.

    Three dimensional structures from OCA and Proteopedia for PTGR1 Gene

    Alternative splice isoforms for PTGR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGR1 Gene

Post-translational modifications for PTGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGR1 Gene

Antibody Products

  • Abcam antibodies for PTGR1

No data available for DME Specific Peptides for PTGR1 Gene

Domains & Families for PTGR1 Gene

Protein Domains for PTGR1 Gene

Suggested Antigen Peptide Sequences for PTGR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14914

UniProtKB/Swiss-Prot:

PTGR1_HUMAN :
  • Belongs to the NADP-dependent oxidoreductase L4BD family.
Family:
  • Belongs to the NADP-dependent oxidoreductase L4BD family.
genes like me logo Genes that share domains with PTGR1: view

No data available for Gene Families for PTGR1 Gene

Function for PTGR1 Gene

Molecular function for PTGR1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
UniProtKB/Swiss-Prot CatalyticActivity:
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.

Enzyme Numbers (IUBMB) for PTGR1 Gene

Gene Ontology (GO) - Molecular Function for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0032440 2-alkenal reductase [NAD(P)] activity IEA --
GO:0036132 13-prostaglandin reductase activity IEA --
GO:0047522 15-oxoprostaglandin 13-oxidase activity IEA --
genes like me logo Genes that share ontologies with PTGR1: view
genes like me logo Genes that share phenotypes with PTGR1: view

Animal Models for PTGR1 Gene

MGI Knock Outs for PTGR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGR1

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTGR1 Gene

Localization for PTGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGR1 Gene COMPARTMENTS Subcellular localization image for PTGR1 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PTGR1: view

Pathways & Interactions for PTGR1 Gene

genes like me logo Genes that share pathways with PTGR1: view

Pathways by source for PTGR1 Gene

Gene Ontology (GO) - Biological Process for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process NAS 8576264
GO:0006693 prostaglandin metabolic process IEA --
GO:0009636 response to toxic substance IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with PTGR1: view

No data available for SIGNOR curated interactions for PTGR1 Gene

Drugs & Compounds for PTGR1 Gene

(5) Drugs for PTGR1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID Experimental Pharma Target 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
para-coumaric acid Experimental Pharma Full agonist, Agonist, Target 0
NAD Pharma Full agonist, Agonist 0

(2) Additional Compounds for PTGR1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with PTGR1: view

Transcripts for PTGR1 Gene

Unigene Clusters for PTGR1 Gene

Prostaglandin reductase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:

Relevant External Links for PTGR1 Gene

GeneLoc Exon Structure for
PTGR1
ECgene alternative splicing isoforms for
PTGR1

Expression for PTGR1 Gene

mRNA expression in normal human tissues for PTGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGR1 Gene

This gene is overexpressed in Liver (x11.3).

Protein differential expression in normal tissues from HIPED for PTGR1 Gene

This gene is overexpressed in Liver, secretome (17.2) and Liver (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTGR1 Gene



Protein tissue co-expression partners for PTGR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGR1 Gene:

PTGR1

SOURCE GeneReport for Unigene cluster for PTGR1 Gene:

Hs.584864

mRNA Expression by UniProt/SwissProt for PTGR1 Gene:

Q14914-PTGR1_HUMAN
Tissue specificity: High expression in the kidney, liver, and intestine but not in leukocytes.
genes like me logo Genes that share expression patterns with PTGR1: view

Primer Products

Orthologs for PTGR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTGR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGR1 34
  • 84.6 (n)
  • 80.24 (a)
PTGR1 35
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGR1 34
  • 88.55 (n)
  • 86.32 (a)
PTGR1 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgr1 34
  • 83.18 (n)
  • 80.55 (a)
Ptgr1 16
Ptgr1 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTGR1 34
  • 99.49 (n)
  • 99.09 (a)
PTGR1 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgr1 34
  • 82.98 (n)
  • 81.76 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGR1 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGR1 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGR1 34
  • 67.58 (n)
  • 64.22 (a)
PTGR1 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGR1 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485344 34
  • 64.23 (n)
  • 61.89 (a)
Str.10740 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23763 34
zebrafish
(Danio rerio)
Actinopterygii ptgr1 34
  • 62.08 (n)
  • 60.86 (a)
ptgr1 35
  • 60 (a)
OneToMany
PTGR1 (2 of 2) 35
  • 52 (a)
OneToMany
Dr.880 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000288 34
  • 52.75 (n)
  • 49.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 24 (a)
OneToMany
-- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03080 34
  • 49.17 (n)
  • 42.86 (a)
rice
(Oryza sativa)
Liliopsida Os04g0497000 34
  • 47.59 (n)
  • 43.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09040 34
  • 47.6 (n)
  • 37.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPB24D3.08c 34
  • 47.43 (n)
  • 39.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
CSA.4563 35
  • 45 (a)
OneToMany
Species where no ortholog for PTGR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGR1 Gene

ENSEMBL:
Gene Tree for PTGR1 (if available)
TreeFam:
Gene Tree for PTGR1 (if available)

Paralogs for PTGR1 Gene

Paralogs for PTGR1 Gene

(2) SIMAP similar genes for PTGR1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PTGR1 Gene

genes like me logo Genes that share paralogs with PTGR1: view

Variants for PTGR1 Gene

Sequence variations from dbSNP and Humsavar for PTGR1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1053959 - 111,597,344(-) AGACA(G/T)CTGAG nc-transcript-variant, reference, missense
rs7854485 -- 111,598,799(+) cCtac(A/G)tatca intron-variant
rs7862831 -- 111,601,084(+) TGGAC(A/C)CTAAA upstream-variant-2KB
rs7868786 -- 111,590,195(+) cagaa(A/G)aaaat intron-variant, upstream-variant-2KB
rs767402 -- 111,581,503(+) CACCT(A/C)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGR1 Gene

Variant ID Type Subtype PubMed ID
dgv1372e199 CNV deletion 23128226
esv2665450 CNV deletion 23128226
esv2678607 CNV deletion 23128226
esv2738936 CNV deletion 23290073
esv275316 CNV gain+loss 21479260
esv3545319 CNV deletion 23714750
esv3621491 CNV loss 21293372
esv3621492 CNV loss 21293372
esv3621494 CNV loss 21293372
esv4254 CNV loss 18987735
esv5602 CNV loss 19470904
nsv1054737 CNV gain 25217958
nsv478735 CNV novel sequence insertion 20440878

Variation tolerance for PTGR1 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGR1 Gene

Disorders for PTGR1 Gene

Relevant External Links for PTGR1

Genetic Association Database (GAD)
PTGR1
Human Genome Epidemiology (HuGE) Navigator
PTGR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGR1

No disorders were found for PTGR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGR1 Gene

Publications for PTGR1 Gene

  1. cDNA cloning, expression, and mutagenesis study of leukotriene B4 12- hydroxydehydrogenase. (PMID: 8576264) Yokomizo T. … Shimizu T. (J. Biol. Chem. 1996) 2 3 4 22 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. (PMID: 17449869) Chou W.L. … Chang Z.F. (J. Biol. Chem. 2007) 2 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 65

Products for PTGR1 Gene

Sources for PTGR1 Gene

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