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PTGIS Gene

protein-coding   GIFtS: 56

GC20M048120
prostaglandin I2 (prostacyclin) synthase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for PTGIS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
prostaglandin I2 (prostacyclin) synthase1 2     cytochrome P450, family 8, subfamily A, polypeptide 12
CYP8A11 2 3 5     prostacyclin synthase2
PGIS1 2 5     PTGI2
CYP82 3 5     MGC1268602
Prostaglandin I2 synthase2 3     EC 5.3.99.43
MGC1268582     

External Ids:    HGNC: 96031   Entrez Gene: 57402   Ensembl: ENSG000001242127   UniProtKB: Q166473   

Search outside databases for aliases for PTGIS gene

Previous GC identifers: GC20M047848 GC20M048758 GC20M048805 GC20M047553

Summaries
for PTGIS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  User Feedback		 Entrez Gene summary for PTGIS:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence
similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of
prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An
imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial
infarction, stroke, and atherosclerosis. (provided by RefSeq)

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)

Genomic Views
for PTGIS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the PTGIS gene upstream (promoter) region "":
AP-1   c-Fos   c-Jun   NF-kappaB1   p53   AREB6   NF-kappaB   POU3F1   RP58   Tal-1beta   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for PTGIS:  ""
MePH28261-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

PTGIS Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048120:  view genomic region     (about GC identifiers)

Start:
 48,120,411 bp from pter
End:
 48,184,707 bp from pter
Size:
 64,297 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  

Proteins
for PTGIS gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647 (See protein sequence)
Recommended Name: Prostacyclin synthase  
Size: 500 amino acids; 57104 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
PDB structure from "" and Proteopedia "" :
2IAG (3D) ""    3B6H (3D) ""    
Secondary accessions: Q3MII8 Q9HAX2 Q9HAX3 Q9HAX4

REFSEQ proteins: NP_000952.1  

ENSEMBL proteins: 
ENSP00000244043 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Browse Human Recombinant Proteins at Sigma-Aldrich
"" Browse R&D Systems for human recombinant proteins
""Enzo Life Sciences proteins for PTGIS
""HuPro® and/or Recombinant Proteins from Abnova for PTGIS ""
"" Origene Purified Recombinant Human Protein: PTGIS
""Novus Biologicals Proteins for PTGIS  ""
Novus Biologicals Lysates for PTGIS
""Browse Sino Biological Recombinant Proteins  ""

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005788 endoplasmic reticulum lumen EXP15115769
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
About this table

"" PTGIS for ontologies           About GeneDecksing



Antibodies for PTGIS: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Sigma-Aldrich Antibodies for PTGIS
"" Browse R&D Systems for Antibodies
""Monoclonal and Polyclonal Antibodies from Abnova (PTGIS)
""Browse Origene Antibodies ""
""Novus Biologicals Antibodies for PTGIS
""Browse antibodies at Epitomics

Assays for PTGIS: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Enzo Life Sciences assays for PTGIS

Protein Domains/
Families
for PTGIS gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR001128 Cyt_P450
 IPR002403 Cyt_P450_E_grp-IV

Graphical View of Domain Structure for InterPro Entry Q16647

ProtoNet protein and cluster: Q16647

1 Blocks protein family: IPB002403 E-class P450 group IV signature

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Similarity: Belongs to the cytochrome P450 family

Gene Function
for PTGIS gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (PTGIS)
"" Origene 29mer shRNA kits in GFP-retroviral vector: PTGIS
Origene shRNA RFP: PTGIS
Origene basic RS shRNA: PTGIS

""Applied Biosystems Silencer® siRNAs for PTGIS
""Sigma-Aldrich siRNA Panels and siRNA for PTGIS
Sigma-Aldrich shRNA for PTGIS
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector: PTGIS
Origene Myc/DDK tagged cDNA clones in CMV expression vector: PTGIS
Origene untagged cDNA clones in CMV expression vector: PTGIS
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)
Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
(5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate
Enzyme Number (IUBMB): EC 5.3.99.4 

Genatlas biochemistry entry for PTGIS:
prostaglandin 12 synthase

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0004497 monooxygenase activity IEA--
GO:0005506 iron ion binding ----
GO:0008116 prostaglandin-I synthase activity EXP15115769
GO:0009055 electron carrier activity IEA--
GO:0016853 isomerase activity IEA--
About this table

"" PTGIS for ontologies           About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele"") (MGI details for Ptgis):

cardiovascular systemhomeostasis/metabolismrenal/urinary system

"" PTGIS for phenotypes           About GeneDecksing

Pathways & Interactions
for PTGIS gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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"" PTGIS for pathways           About GeneDecksing

3 "" Millipore Pathways for PTGIS
  ""  Transcription PPAR Pathway
Prostaglandin 2 biosynthesis and metabolism FM
HETE and HPETE biosynthesis and metabolism

2 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  PTGIS  (Your Favorite Gene powered by Ingenuity)
  ""  Eicosanoid Signaling
Arachidonic Acid Metabolism

2 "" Kegg Pathways  (Kegg details for PTGIS):
  ""  hsa00590 Arachidonic acid metabolism
hsa01100 Metabolic pathways

"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTGIS

5/7 Interacting proteins for PTGIS (ENSP000002440433) via UniProtKB, MINT, and/or STRING (see all 7 ) ""
InteractantInteraction Details
GeneCardExternal ID(s)
PTGESENSP000003423853STRING: ENSP00000342385
PTGES2ENSP000003453413STRING: ENSP00000345341
PTGS1ENSP000003546123STRING: ENSP00000354612
PTGS2ENSP000003564383STRING: ENSP00000356438
TBXAS1ENSP000003380873STRING: ENSP00000338087
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA--
GO:0006629 lipid metabolic process NAS8812456
GO:0006633 fatty acid biosynthetic process IEA--
About this table

"" PTGIS for ontologies           About GeneDecksing


Drugs & Compounds
for PTGIS gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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"" PTGIS for compounds           About GeneDecksing

"" Enzo Life Sciences drugs & compounds for PTGIS
""Sigma-Aldrich Small Molecules for PTGIS:
Small Molecule - Ligand

"" Browse Tocris compounds for PTGIS
10/114 ""Novoseek chemical compound relationships for PTGIS gene (see all 114 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
prostacyclin 100.00 568 10076157 (12), 12019369 (8), 8051072 (7), 3917545 (6) (see all 100)
prostaglandin h2 57.35 30 18590695 (3), 18032380 (2), 16406803 (2), 11006279 (2) (see all 25)
thromboxane 42.78 34 19735918 (2), 17189713 (2), 9682267 (1), 9202154 (1) (see all 32)
peroxynitrite 35.78 29 9820830 (4), 9278151 (3), 10335439 (3), 17164139 (2) (see all 20)
thromboxane a2 32.38 30 8238203 (3), 19735918 (3), 9367522 (2), 12738712 (2) (see all 24)
monocrotaline 20.27 14 15684702 (5), 11034952 (5), 18612919 (2), 17635855 (1) (see all 5)
6-ketoprostaglandin f1alpha 18.48 13 9933282 (2), 2817083 (2), 8263161 (1), 8027246 (1) (see all 11)
prostaglandin 14.47 23 2107185 (2), 10809766 (2), 10334892 (2), 6992239 (1) (see all 20)
tranylcypromine 13.99 9 2514665 (2), 8307867 (1), 7556492 (1), 6793337 (1) (see all 8)
onoo 13.75 9 17164139 (5), 16186418 (3), 15370068 (1)
About this table


Transcripts
for PTGIS gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Abnova Chimera RNAi Products for Gene knock-down (PTGIS)
""Applied Biosystems Silencer® siRNAs:  NM_000961  
"" Origene 29mer shRNA kits in GFP-retroviral vector: PTGIS
Origene shRNA RFP: PTGIS
Origene basic RS shRNA: PTGIS

""Sigma-Aldrich siRNA Panels and siRNA for PTGIS
Sigma-Aldrich shRNA for PTGIS
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""2 SABiosciences microRNAs that regulate PTGIS: ""
hsa-miR-149 hsa-miR-544
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_000961  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: PTGIS
Origene Myc/DDK tagged cDNA clones in CMV expression vector: PTGIS
Origene untagged cDNA clones in CMV expression vector: PTGIS
Primers:"" Origene genome-wide validated SYBR primer pairs: PTGIS
""SABiosciences RT2 qPCR Primer Assay for PTGIS: PPH02582A ""

REFSEQ mRNAs for PTGIS gene: 

NM_000961.3  

Additional cDNA sequence: 

AF297048.1 AF297049.1 AF297050.1 AF297051.1 AF297052.1 AK055640.1 BC101809.1 BC101811.1 
BC143381.1 D38145.1 

2 DOTS entries:

DT.306642  DT.312136 

24/65 AceView cDNA sequences (see all 65 ):

AA126676 CD014051 NM_000961 BG747647 AA112885 BI913761 AI969383 BE466814 
BP374626 D38145 CA415428 AA150210 AF297048 AA083871 AF297052 AF297051 
AF297049 AF297050 CD014146 AL700270 F04077 BE674368 AK055640 AI239580 

"" highest scoring ESTs for PTGIS:

D38145 AF297048 AF297049 AF297050 AF297051 AF297052 AA026093 AA362696 AI677655 AI969383 

Unigene Cluster for PTGIS:

Prostaglandin I2 (prostacyclin) synthase
Hs.302085  [show with all ESTs]
Unigene Representative Sequence: NM_000961


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000478764  ENST00000478971  ENST00000244043  

Expression
for PTGIS gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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PTGIS expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for PTGIS

1""  / 2""  / 3""

8 probe-sets matching PTGIS gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
759_at2, 3 U95-A 1 0.88 1.00 0.49 0.95 D38145 1.00 1.00 1.00 1
36533_at2, 3 U95-A 1 0.50 1.00 0.97 1.18 D83402 0.20 1.00 0.72 1
211892_s_at2, 3 U133-A 1 0.91 1.00 -- -- AF297052 0.80 1.00 0.91 1
210702_s_at2, 3 U133-A 1 0.91 1.00 -- -- D38145 1.00 1.00 1.00 1
208131_s_at2, 3 U133-A 1 0.36 1.00 -- -- NM_000961 0.60 1.00 0.82 1
211892_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
210702_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
208131_s_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
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Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.302085

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Tissue specificity: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate

Primers:"" Origene genome-wide validated SYBR primer pairs: PTGIS ""
""SABiosciences RT2 qPCR Primer Assay for PTGIS: PPH02582A ""

Orthologs
for PTGIS gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for PTGIS gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 PTGIS1   -- prostaglandin I2 (prostacyclin) synthase 86.83(n)
87.82(a)		 485919  XM_543043.2  XP_543043.2 
chimpanzee
(Pan troglodytes)		 PTGIS1   -- prostaglandin I2 (prostacyclin) synthase 97.06(n)
97.13(a)		 458323  XM_514713.2  XP_514713.2 
cow
(Bos taurus)		 PTGIS1   -- prostaglandin I2 (prostacyclin) synthase 87.2(n)
87.6(a)		 282021  NM_174444.1  NP_776869.1 
rat
(Rattus norvegicus)		 Ptgis1   -- prostaglandin I2 (prostacyclin) synthase 82.3(n)
84.17(a)		 25527  NM_031557.2  NP_113745.1 
mouse
(Mus musculus)		 Ptgis1, 5 25
 prostaglandin I2 (prostacyclin) synthase1, 5 84.24(n)1
86.17(a)1		 192231  NM_008968.31  NP_032994.11 
 AB0016075  AB0407505  (see all 12)
About this table        Species with no ortholog for PTGIS

ENSEMBL Gene Tree for PTGIS

Paralogs
for PTGIS gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for PTGIS gene
CYP39A12  CYP7A12  CYP8B12  CYP7B12  

"" PTGIS for paralogs           About GeneDecksing


Genomic Variants
for PTGIS gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/591 NCBI SNPs in PTGIS are shown (see all 591 )
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 134)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
""
rs56021,2
C,F,O,A,H48121978(-) AAAGAC/TGTGCT 1 -- ut31""19Minor allele frequency- N:0.00MN EA NA NS 1374""
--
rs55961,2
C,F,A,H48123087(-) acataC/Aaaaaa 1 -- ut31""3Minor allele frequency- A:0.40MN NA 152""
""
rs5741131,2
C,F,A,H44868763(-) tgcccA/Gagaac 1 -- ng31""14Minor allele frequency- G:0.35NS EA NA 1010""
--
rs4921951,2
C,F,A,H48120999(-) tgcctG/Tggcct 1 -- ut31 ese3""3Minor allele frequency- T:0.50NA 6""
""
rs56261,2
C,F,H48140744(-) AAAGTC/TGCCTG 2 R C ref1 mis1 ese3""16Minor allele frequency- T:0.01MN NS EA NA 1884""
--
rs116985351,2
C,A,H48123066(+) cgcacT/Cgccac 1 -- ut31""3Minor allele frequency- C:0.17NA 6""
--
rs46471,2
C,F,A48120777(-) caaaaC/Tgagat 1 -- ut31""13Minor allele frequency- T:0.17MN EA NS NA 2654""
""
rs56191,2
C,F,A48120843(-) AAATTC/TGCTGG 1 -- ut31 ese3""9Minor allele frequency- T:0.09MN NS EA NA 820""
""
rs133060301,2
C,F,H48140770(-) GGACAA/CGGACC 2 K T ref1 mis1""8Minor allele frequency- C:0.00NS EA MN WA 1260""
--
rs55821,2
C,F,H48184682(-) CCCCGC/TCAGCC 1 -- ut51""1Minor allele frequency- T:0.05MN 68""
About this table

HapMap Linkage Disequilibrium images for PTGIS (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
      Database of Genomic Variants (DGV) variations for PTGIS: --

Disorders & Mutations
for PTGIS gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601699   disorders: 145500  

10/78 ""Novoseek disease relationships for PTGIS gene (see all 78 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
hypertension pulmonary 22.38 27 19838762 (6), 15684702 (5), 12019369 (3), 11034952 (3) (see all 10)
spondylitis 7.03 5 16059927 (4), 16081819 (1)
essential hypertension 5.40 11 12924623 (4), 11924728 (3), 11368458 (3), 9561119 (1)
infarction; myocardial 4.61 22 19040046 (5), 19534932 (4), 19327107 (4), 19065539 (3) (see all 7)
cteph 3.90 3 15182267 (3)
cerebral infarction 3.62 6 11130769 (3), 11997284 (2), 12372404 (1)
lung tumor 3.45 5 19138979 (2), 17374734 (1), 15313935 (1), 11830527 (1)
colorectal polyp 2.47 2 16537708 (2)
familial pulmonary arterial hypertension 2.13 1 16373865 (1)
endotoxic shock 1.95 2 17164139 (1), 11076704 (1)
About this table

Locus Specific Mutation Databases: PTGIS
Human Gene Mutation Database: PTGIS
Genetic Association Database: PTGIS
Human Genome Epidemiology Navigator: PTGIS (27 documents)

Medical News
for PTGIS gene

(Possibly Related Articles in Doctor's Guide)
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Publications
for PTGIS gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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  User Feedback		10/205 PubMed articles for PTGIS gene (see all 205 ):

Search for PTGIS gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing PTGIS gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5740 HGNC: 9603 AceView: PTGIS Ensembl:ENSG00000124212 euGenes: HUgn5740
ECgene: PTGIS Kegg: 5740 H-InvDB: PTGIS

Other Databases showing PTGIS gene

(According to HUGE)
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Specialized Databases showing PTGIS gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp8a1.htm

Intellectual Property
for PTGIS gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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  User Feedback		Patent Information for PTGIS gene: ""
Search GeneIP for patents involving PTGIS

GeneCards and IP: ""
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


Services
for PTGIS gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PTGIS:
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"" Millipore Preclinical / Clinical Development Services
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"" Predesigned and custom siRNAs for PTGIS"" Antibodies for PTGIS
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"" Lentivirus-delivered shRNAs for PTGIS"" Small molecules for PTGIS
"" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
"" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


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"" Recombinant Proteins (PTGIS)
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"" Search for Antibodies & Assays

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"" Search Tocris compounds for PTGIS
"" Regulatory tfbs in PTGIS upstream (promoter) region
"" Search Chromatin IP Primers for PTGIS
"" DNA Methylation qPCR Primer Assays for PTGIS
"" RT2 qPCR Primer Assay for PTGIS
"" Search GNC Networks for PTGIS
"" microRNAs that regulate PTGIS
""""""""
"" Assays/Drugs/Proteins for PTGIS
"" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
"" Novus Tissue Slides
"" Antibodies for PTGIS
"" Proteins for PTGIS
"" Lysates for PTGIS
"" Browse antibodies at Epitomics
"" Browse Sino Biological Proteins and Antibodies
"" Browse Sino Biological cDNA Clones
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GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

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acyl-CoA synthetase family member 3
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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

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