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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGIS Gene

protein-coding   GIFtS: 66
GCID: GC20M048120

Prostaglandin I2 (Prostacyclin) Synthase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prostaglandin I2 (Prostacyclin) Synthase1 2     Polypeptide 11
CYP82 3 5     Subfamily A1
CYP8A12 3 5     PTGI2
Prostaglandin I2 Synthase2 3     Cytochrome P450, Family 8, Subfamily A, Polypeptide 12
PGIS2 5     Prostacyclin Synthase2
Cytochrome P4501     EC 5.3.99.43
Family 81     

External Ids:    HGNC: 96031   Entrez Gene: 57402   Ensembl: ENSG000001242127   OMIM: 6016995   UniProtKB: Q166473   

Export aliases for PTGIS gene to outside databases

Previous GC identifers: GC20M047848 GC20M048758 GC20M048805 GC20M047553 GC20M044868


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGIS Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of
sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the
conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet
aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the
development of myocardial infarction, stroke, and atherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTGIS Gene: 
PTGIS (prostaglandin I2 (prostacyclin) synthase) is a protein-coding gene. Diseases associated with PTGIS include endometritis, and acute endometritis, and among its related super-pathways are Arachidonic acid metabolism and Metabolic pathways. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP39A1.

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)

Gene Wiki entry for PTGIS (Prostacyclin synthase) Gene

PharmGKB "VIP" summary for PTGIS


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGIS gene promoter:
         AREB6   c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGIS promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGIS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGIS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

PTGIS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGIS gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048120:  view genomic region     (about GC identifiers)

Start:
48,120,411 bp from pter      End:
48,184,707 bp from pter
Size:
64,297 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647 (See protein sequence)
Recommended Name: Prostacyclin synthase  
Size: 500 amino acids; 57104 Da
Cofactor: Heme group
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
2 PDB 3D structures from and Proteopedia for PTGIS:
2IAG (3D)        3B6H (3D)    
Secondary accessions: Q3MII8 Q9HAX2 Q9HAX3 Q9HAX4

Explore the universe of human proteins at neXtProt for PTGIS: NX_Q16647

Explore proteomics data for PTGIS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16647

  • PTGIS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGIS Protein Expression
    REFSEQ proteins: NP_000952.1  
    ENSEMBL proteins: 
     ENSP00000244043  
    Reactome Protein details: Q16647
    Human Recombinant Protein Products for PTGIS: 
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    OriGene Purified Protein for PTGIS
    OriGene Protein Over-expression Lysate for PTGIS
    OriGene MassSpec for PTGIS 
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    Novus Biologicals PTGIS Proteins
    Novus Biologicals PTGIS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGIS 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0005634nucleus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005901caveola IDA--

    PTGIS for ontologies           About GeneDecksing



    PTGIS Antibody Products: 
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    Assay Products for PTGIS: 
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    Cloud-Clone Corp. ELISAs for PTGIS 
    Cloud-Clone Corp. CLIAs for PTGIS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP8A1 
    CYP5, CYP7 and CYP8 families

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR002403 Cyt_P450_E_grp-IV
     IPR024204 Cyt_P450_CYP7A1-type
     IPR027286 PTGIS

    Graphical View of Domain Structure for InterPro Entry Q16647

    ProtoNet protein and cluster: Q16647

    1 Blocks protein domain: IPB002403 E-class P450 group IV signature

    UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
    Similarity: Belongs to the cytochrome P450 family


    PTGIS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTGIS_HUMAN, Q16647
    Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate

         Genatlas biochemistry entry for PTGIS:
    prostaglandin 12 synthase

         Enzyme Number (IUBMB): EC 5.3.99.41

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0008116prostaglandin-I synthase activity IDA--
    GO:0009055electron carrier activity IEA--
         
    PTGIS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTGIS:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ptgis):
     cardiovascular system  homeostasis/metabolism  renal/urinary system 

    PTGIS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptgistm1Tada for PTGIS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGIS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGIS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGIS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGIS 

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGIS (see all 43):
    hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-4254 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4267 hsa-miR-4314 hsa-miR-3658
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PTGIS (NM_000961)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGIS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTGIS About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    Arachidonic acid metabolism0.44
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.42
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    4Synthesis of bile acids and bile salts
    Synthesis of bile acids and bile salts0.87
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol0.61
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol0.87
    Synthesis of bile acids and bile salts via 27-hydroxycholesterol0.56
    Bile acid and bile salt metabolism0.74
    5Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PTGIS
        Transcription PPAR Pathway
    Prostaglandin 2 biosynthesis and metabolism FM
    HETE and HPETE biosynthesis and metabolism


    3 GeneGo (Thomson Reuters) Pathways for PTGIS
        HETE and HPETE biosynthesis and metabolism
    Prostaglandin 2 biosynthesis and metabolism FM
    Transcription PPAR Pathway

    3 BioSystems Pathways for PTGIS
        Adipogenesis
    Eicosanoid Synthesis
    Prostaglandin Synthesis and Regulation

    5/15        Reactome Pathways for PTGIS (see all 15)
        Cytochrome P450 - arranged by substrate type
    Eicosanoids
    Bile acid and bile salt metabolism
    Metabolism
    Sterols are 12-hydroxylated by CYP8B1

    2 PharmGKB Pathways for PTGIS
        Celecoxib Pathway, Pharmacodynamics
    Phenytoin Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for PTGIS):
        Arachidonic acid metabolism
    Metabolic pathways


    PTGIS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTGIS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for PTGIS (ENSP000002440434) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HPGDSENSP000002952564STRING: ENSP00000295256
    PTGDSENSP000003606874STRING: ENSP00000360687
    PTGESENSP000003423854STRING: ENSP00000342385
    PTGES2ENSP000003453414STRING: ENSP00000345341
    PTGS1ENSP000003546124STRING: ENSP00000354612
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IDA--
    GO:0006690icosanoid metabolic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019371cyclooxygenase pathway TAS--

    PTGIS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGIS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for PTGIS

    Browse Tocris compounds for PTGIS

    3 HMDB Compounds for PTGIS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--
    Prostaglandin I2(5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoate (see all 20)35121-78-9--

    3 DrugBank Compounds for PTGIS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phenylbutazone-- 50-33-9targetinhibitor3917545 6434940 3517382 17139284 17016423
    EpoprostenolPGI2 (see all 3)35121-78-9targetinducer20357747 18081314
    (6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID-- --target--10592235

    10/29 Novoseek inferred chemical compound relationships for PTGIS gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostacyclin 94.4 476 8051072 (7), 12019369 (6), 18835932 (6), 8034007 (5) (see all 99)
    prostaglandin-h2 90.7 44 18590695 (3), 16406803 (3), 11006279 (2), 18032380 (2) (see all 18)
    pgh2 78.8 9 9721692 (1), 15370068 (1), 18081314 (1), 12512699 (1) (see all 7)
    thromboxane a2 78 36 9367522 (2), 12738712 (2), 8263161 (1), 11006279 (1) (see all 19)
    6-ketoprostaglandin f1alpha 77.4 10 9933282 (2), 8263161 (1), 12019369 (1), 19040046 (1) (see all 7)
    thromboxane 77.2 26 11756341 (2), 17189713 (2), 8051072 (1), 12154203 (1) (see all 18)
    peroxynitrite 70.1 22 9278151 (3), 10335439 (3), 14504187 (2), 17164139 (2) (see all 14)
    arachidonic acid 65.7 28 16537708 (2), 15708381 (2), 17115695 (2), 18835243 (2) (see all 10)
    dodecylphosphocholine 64.3 2 12590920 (1)
    prostaglandin 62.7 17 15115769 (1), 19046748 (1), 16537708 (1), 19327107 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about PTGIS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTGIS gene: 
    NM_000961.3  

    Unigene Cluster for PTGIS:

    Prostaglandin I2 (prostacyclin) synthase
    Hs.302085  [show with all ESTs]
    Unigene Representative Sequence: NM_000961
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244043(uc002xut.3 uc010zyi.2) ENST00000478971
    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGIS (see all 43):
    hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-4254 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4267 hsa-miR-4314 hsa-miR-3658
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGIS
    Sirion Biotech Customized lentivirus for stable overexpression of PTGIS 
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    Primer
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    OriGene qPCR primer pairs and template standards for PTGIS
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGIS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGIS

    Additional mRNA sequence: 

    AF297048.1 AF297049.1 AF297050.1 AF297051.1 AF297052.1 AK055640.1 BC101809.1 BC101811.1 
    BC143381.1 D38145.1 

    2 DOTS entries:

    DT.306642  DT.312136 

    24/65 AceView cDNA sequences (see all 65):

    CA415428 CD014051 AF297049 NM_000961 AF297050 CD014146 AF297051 AF297052 
    AA083871 BE466814 AL700270 BG747647 BI913761 AA126676 BP374626 AA150210 
    AF297048 F04077 D38145 AA112885 AI969383 AL702464 AI125977 AW196414 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGIS expression in normal human tissues (normalized intensities)      PTGIS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTGIS Expression
    About this image


    PTGIS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             optic nerve head astrocytes   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
             mouse/organ system/cardiovascular system   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   

    See PTGIS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGIS

    SOURCE GeneReport for Unigene cluster: Hs.302085

    UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
    Tissue specificity: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including PTGIS: 
              Endothelial Cell Biology in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGIS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PTGIS gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgis1 , 5 prostaglandin I2 (prostacyclin) synthase1, 5 84.24(n)1
    86.17(a)1
      2 (87.22 cM)5
    192231  NM_008968.31  NP_032994.11 
     1671918055 
    lizard
    (Anolis carolinensis)
    Reptilia PTGIS6
    prostaglandin I2 (prostacyclin) synthase
    56(a)
    1 ↔ 1
    4(146807129-146853188)
    zebrafish
    (Danio rerio)
    Actinopterygii ptgis1 prostaglandin I2 (prostacyclin) synthase 55.39(n)
    49.79(a)
      559148  NM_001111160.1  NP_001104630.1 


    ENSEMBL Gene Tree for PTGIS (if available)
    TreeFam Gene Tree for PTGIS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGIS gene
    CYP39A12  CYP7A12  CYP7B12  CYP8B12  
    4 SIMAP similar genes for PTGIS using alignment to 3 protein entries:     PTGIS_HUMAN (see all proteins):
    PGIS    CYP8B1    CYP7A1    CYP7B1

    PTGIS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1580 SNPs in PTGIS are shown (see all 1580)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475347091,2
    C,Funtested148101908(+) AGAAGG/AAAGAG 2 /F syn11Minor allele frequency- A:0.00NA 4552
    VAR_0109154
    ----see VAR_0109152 P L mis40--------
    rs1422130011,2
    C--44925028(+) TACAC-/TTTTTTT 1 -- int10--------
    rs1391814611,2
    C--48090941(+) AGTGAC/TGGGGA 1 -- ds50010--------
    rs5741131,2
    C,F,A,H--48091199(-) TGCCCA/GAGAAC 1 -- ds500130Minor allele frequency- G:0.27NS EA NA WA CSA 2777
    rs1179908361,2
    C,F--48091233(+) CAGTTT/GCTTTC 1 -- ds50011Minor allele frequency- G:0.02NA 120
    rs1156594211,2
    C,F--48091245(+) CTGTAA/GAAACG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1499670731,2
    C--48091249(+) AAAAAC/TGGGGA 1 -- ds50010--------
    rs757775271,2
    C,F--48091370(+) GAGCTG/TACCTC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs5719071,2
    C,F,H--48091390(-) TTGGCC/TGTGCC 1 -- ds500114Minor allele frequency- T:0.08NS EA NA CSA WA 1884

    HapMap Linkage Disequilibrium report for PTGIS (48120411 - 48184707 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PTGIS: --

    Human Gene Mutation Database (HGMD): PTGIS

    Locus Specific Mutation Databases (LSDB): PTGIS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGIS
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGIS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601699   
    OMIM disorders: 145500  
    20/41 diseases for PTGIS (see all 41):    About MalaCards
    endometritis    acute endometritis    chronic thromboembolic pulmonary hypertension    adenomyosis
    balanitis    cerebral infarction    myocardial infarction    hepatopulmonary syndrome
    spondyloarthropathy    patent ductus arteriosus    primary pulmonary hypertension    atherosclerosis
    essential hypertension    cytochrome p450    breast cancer susceptibility    hypertension
    papillary thyroid carcinoma    esophageal adenocarcinoma    thromboembolism    thrombosis

    1 disease from the University of Copenhagen DISEASES database for PTGIS:
    Hypertension

    PTGIS for disorders           About GeneDecksing

    10/23 Novoseek inferred disease relationships for PTGIS gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertension pulmonary 43.6 12 10359560 (2), 11034952 (2), 15541968 (2), 15049720 (1) (see all 7)
    vascular diseases 32.7 2 7488205 (1), 17164139 (1)
    shock endotoxic 29.7 1 17164139 (1)
    cerebral infarction 28.9 1 12372404 (1)
    essential hypertension 28.3 2 12924623 (1)
    lung tumor 26.8 4 19138979 (2), 15313935 (1)
    thrombosis 13 2 16186418 (1)
    myocardial infarction 12.1 5 19046748 (1), 19040046 (1), 19327107 (1), 19534932 (1)
    atherosclerosis 8.64 3 20348234 (1), 17164139 (1)
    cardiovascular diseases 8.64 12 20357747 (2), 15853702 (2), 7958234 (1), 17073611 (1) (see all 6)

    Genetic Association Database (GAD): PTGIS
    Human Genome Epidemiology (HuGE) Navigator: PTGIS (33 documents)

    Export disorders for PTGIS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGIS gene, integrated from 9 sources (see all 215):
    (articles sorted by number of sources associating them with PTGIS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. (PubMed id 18081314)1, 7, 9 Ruan K.H....Cervantes V. (2008)
    2. Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. (PubMed id 16537708)1, 4, 9 Poole E.M....Ulrich C.M. (2006)
    3. Crystal structure of the human prostacyclin synthase. (PubMed id 17020766)1, 2, 9 Chiang C.W....Chan N.L. (2006)
    4. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. (PubMed id 19327107)1, 4, 9 Xie X....Liu F. (2009)
    5. Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1). (PubMed id 12428676)1, 4, 9 Chevalier D....Broly F. (2002)
    6. Characterization of new mutations in the coding sequence and 5'- untranslated region of the human prostacylcin synthase gene (CYP8A1). (PubMed id 11281454)1, 2, 9 Chevalier D....Broly F. (2001)
    7. [Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China] (PubMed id 19040046)1, 4, 9 Xie X....Liu F. (2008)
    8. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. (PubMed id 12372404)1, 4, 9 Nakayama T....Oates J.A. (2002)
    9. Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. (PubMed id 8812456)1, 3, 9 Yokoyama C.... Tanabe T. (1996)
    10. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4, 9 Dagle J.M....Murray J.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5740 HGNC: 9603 AceView: PTGIS Ensembl:ENSG00000124212 euGenes: HUgn5740
    ECgene: PTGIS Kegg: 5740 H-InvDB: PTGIS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGIS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTGIS Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp8a1.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTGIS gene:
    Search GeneIP for patents involving PTGIS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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