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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGIS Gene

protein-coding   GIFtS: 65
GCID: GC20M048120

prostaglandin I2 (prostacyclin) synthase
 Explore 37 diseases affiliated with
PTGIS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTGIS    

Aliases
for PTGIS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Prostaglandin I2 (Prostacyclin) Synthase1 2     PTGI2
CYP8A11 2 3 5     Cytochrome P450, Family 8, Subfamily A, Polypeptide 12
PGIS1 2 5     Prostacyclin Synthase2
CYP82 3 5     EC 5.3.99.43
Prostaglandin I2 Synthase2 3     

External Ids:    HGNC: 96031   Entrez Gene: 57402   Ensembl: ENSG000001242127   OMIM: 6016995   UniProtKB: Q166473   

Export aliases for PTGIS gene to outside databases

Previous GC identifers: GC20M047848 GC20M048758 GC20M048805 GC20M047553 GC20M044868


Summaries
for PTGIS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTGIS:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence
similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of
prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An
imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial
infarction, stroke, and atherosclerosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)

Gene Wiki entry for PTGIS (Prostacyclin synthase)

PharmGKB "VIP" summary for PTGIS


Genomic Views
for PTGIS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGIS gene promoter:
         AREB6   c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTGIS promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGIS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGIS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

PTGIS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGIS gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048120:  view genomic region     (about GC identifiers)

Start:
 48,120,411 bp from pter      End:
 48,184,707 bp from pter
Size:
 64,297 bases      Orientation:
 minus strand

Proteins
for PTGIS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647 (See protein sequence)
Recommended Name: Prostacyclin synthase  
Size: 500 amino acids; 57104 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
2 PDB 3D structures from and Proteopedia for PTGIS:
2IAG (3D)        3B6H (3D)    
Secondary accessions: Q3MII8 Q9HAX2 Q9HAX3 Q9HAX4

Explore the universe of human proteins at neXtProt for PTGIS: NX_Q16647

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16647

    • PTGIS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000952.1  
    ENSEMBL proteins: 
     ENSP00000244043  
    Reactome Protein details: Q16647
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: PTGIS
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    Novus Biologicals PTGIS Proteins
    Novus Biologicals PTGIS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PTGIS

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0005634nucleus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005788endoplasmic reticulum lumen ----
    GO:0005789endoplasmic reticulum membrane TAS--


    PTGIS for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PTGIS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTGIS for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR002403 Cyt_P450_E_grp-IV
     IPR024204 Cyt_P450_CYP7A1-type

    Graphical View of Domain Structure for InterPro Entry Q16647

    ProtoNet protein and cluster: Q16647

    1 Blocks protein family: IPB002403 E-class P450 group IV signature

    UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
    Similarity: Belongs to the cytochrome P450 family


    Function
    for PTGIS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
    Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate

         Genatlas biochemistry entry for PTGIS:
    prostaglandin 12 synthase

    Enzyme Number (IUBMB): EC 5.3.99.41

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PTGIS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGIS
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGIS (see all 43):
    hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-4254 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4267 hsa-miR-4314 hsa-miR-3658
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGIS (see all 7)
    OriGene shRNA RFP: PTGIS
    OriGene siRNA: PTGIS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGIS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PTGIS

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTGIS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTGIS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PTGIS (NM_000961)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGIS 

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    Search LifeMap BioReagents cell lines for PTGIS

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGIS

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0008116prostaglandin-I synthase activity IDA--
    GO:0009055electron carrier activity IEA--


    PTGIS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PTGIS:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Ptgistm1Tada for PTGIS
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ptgis):
     cardiovascular system  homeostasis/metabolism  renal/urinary system 

    PTGIS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTGIS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Arachidonic acid metabolism
    		Arachidonic acid metabolism1.00
    		HETE and HPETE biosynthesis and metabolism0.39
    		Arachidonic acid metabolism0.42
    		Eicosanoid Synthesis0.31
    		HETE and HPETE biosynthesis and metabolism0.39
    2Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)1.00
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    		prostanoid biosynthesis0.50
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    4Cytochrome P450 - arranged by substrate type
    		Cytochrome P450 - arranged by substrate type1.00
    		Phase 1 - Functionalization of compounds0.74
    5Development_Ligand-independent activation of ESR1 and ESR2
    		Transcription_PPAR Pathway0.35
    		Transcription PPAR Pathway0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PTGIS
        Transcription PPAR Pathway
    Prostaglandin 2 biosynthesis and metabolism FM
    HETE and HPETE biosynthesis and metabolism


    3 GeneGo (Thomson Reuters) Pathways for PTGIS
        HETE and HPETE biosynthesis and metabolism
    Prostaglandin 2 biosynthesis and metabolism FM
    Transcription PPAR Pathway

    4 BioSystems Pathways for PTGIS 
        Adipogenesis
    Eicosanoid Synthesis
    Prostaglandin Synthesis and Regulation
    prostanoid biosynthesis

    5/8        Reactome Pathways for PTGIS (see all 8)
        Cytochrome P450 - arranged by substrate type
    Eicosanoids
    Metabolism
    Arachidonic acid metabolism
    Biological oxidations

    2 PharmGKB Pathways for PTGIS
        Celecoxib Pathway, Pharmacodynamics
    Phenytoin Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for PTGIS):
        Arachidonic acid metabolism
    Metabolic pathways


    PTGIS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PTGIS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for PTGIS (ENSP000002440434) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HPGDSENSP000002952564STRING: ENSP00000295256
    PTGDSENSP000003606874STRING: ENSP00000360687
    PTGESENSP000003423854STRING: ENSP00000342385
    PTGES2ENSP000003453414STRING: ENSP00000345341
    PTGS1ENSP000003546124STRING: ENSP00000354612
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IDA--
    GO:0006690icosanoid metabolic process TAS--
    GO:0006692prostanoid metabolic process ----
    GO:0006805xenobiotic metabolic process TAS--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA--


    PTGIS for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTGIS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGIS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for PTGIS

    Browse Tocris compounds for PTGIS

    3 HMDB Compounds for PTGIS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--
    Prostaglandin I2(5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoate (see all 20)35121-78-9--

    3 DrugBank Compounds for PTGIS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phenylbutazone-- 50-33-9targetinhibitor3917545 6434940 3517382 17139284 17016423
    EpoprostenolPGI2 (see all 3)35121-78-9targetinducer20357747 18081314
    (6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID-- --target--10592235

    10/29 Novoseek chemical compound relationships for PTGIS gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostacyclin 94.4 476 8051072 (7), 12019369 (6), 18835932 (6), 8034007 (5) (see all 99)
    prostaglandin-h2 90.7 44 18590695 (3), 16406803 (3), 11006279 (2), 18032380 (2) (see all 18)
    pgh2 78.8 9 9721692 (1), 15370068 (1), 18081314 (1), 12512699 (1) (see all 7)
    thromboxane a2 78 36 9367522 (2), 12738712 (2), 8263161 (1), 11006279 (1) (see all 19)
    6-ketoprostaglandin f1alpha 77.4 10 9933282 (2), 8263161 (1), 12019369 (1), 19040046 (1) (see all 7)
    thromboxane 77.2 26 11756341 (2), 17189713 (2), 8051072 (1), 12154203 (1) (see all 18)
    peroxynitrite 70.1 22 9278151 (3), 10335439 (3), 14504187 (2), 17164139 (2) (see all 14)
    arachidonic acid 65.7 28 16537708 (2), 15708381 (2), 17115695 (2), 18835243 (2) (see all 10)
    dodecylphosphocholine 64.3 2 12590920 (1)
    prostaglandin 62.7 17 15115769 (1), 19046748 (1), 16537708 (1), 19327107 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about PTGIS 

    Transcripts
    for PTGIS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTGIS gene: 
    NM_000961.3  

    Unigene Cluster for PTGIS:

    Prostaglandin I2 (prostacyclin) synthase
    Hs.302085  [show with all ESTs]
    Unigene Representative Sequence: NM_000961
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244043(uc002xut.3 uc010zyi.2) ENST00000478971 ENST00000478764


    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGIS (see all 43):
    hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-4254 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4267 hsa-miR-4314 hsa-miR-3658
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGIS (see all 7)
    OriGene shRNA RFP: PTGIS
    OriGene siRNA: PTGIS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGIS
    Clone
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    GenScript: all cDNA clones in your preferred vector: PTGIS (NM_000961)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGIS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGIS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGIS

    Additional cDNA sequence: 

    AF297048.1 AF297049.1 AF297050.1 AF297051.1 AF297052.1 AK055640.1 BC101809.1 BC101811.1 
    BC143381.1 D38145.1 

    2 DOTS entries:

    DT.306642  DT.312136 

    24/65 AceView cDNA sequences (see all 65):

    AF297050 F04077 AF297052 AF297051 AF297049 AA112885 BP374626 NM_000961 
    BG747647 BI913761 CA415428 AI969383 D38145 BE466814 AA083871 CD014146 
    AL700270 CD014051 AF297048 AA150210 AA126676 AW087769 BG749012 AA148801 

    GeneLoc Exon Structure


    Expression
    for PTGIS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGIS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTGIS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See PTGIS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGIS

    SOURCE GeneReport for Unigene cluster: Hs.302085

    UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
    Tissue specificity: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including PTGIS: 
              Endothelial Cell Biology in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGIS

    Orthologs
    for PTGIS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PTGIS gene from 2/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia PTGIS6
    		 --
    		 55(a)
    		 1 ↔ 1
    		 4(146811152-146838487)
    zebrafish
    (Danio rerio)    		 Actinopterygii ptgis1 prostaglandin I2 (prostacyclin) synthase 55.39(n)
    49.79(a)    		   559148  NM_001111160.1  NP_001104630.1 


    ENSEMBL Gene Tree for PTGIS (if available)
    TreeFam Gene Tree for PTGIS (if available) 

    Paralogs
    for PTGIS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGIS gene
    CYP39A12  CYP7A12  CYP7B12  CYP8B12  
    4 SIMAP similar genes for PTGIS using alignment to 3 protein entries:     PTGIS_HUMAN (see all proteins):
    PGIS    CYP8B1    CYP7A1    CYP7B1

    PTGIS for paralogs           About GeneDecksing



    Genomic Variants
    for PTGIS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1334 NCBI SNPs in PTGIS are shown (see all 1334)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1156594211,2
    		C,F,--44868809(+) CTGTAA/GAAACG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs757775271,2
    		F,--44868934(+) GAGCTG/TACCTC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs5719071,2
    		C,F,H,--44868954(-) TTGGCC/TGTGCC 1 -- ds500114Minor allele frequency- T:0.08NS EA NA CSA WA 1884
    rs171815211,2
    		C,--44869017(+) AATAGA/GTTTCA 1 -- ut314Minor allele frequency- G:0.01NA EA 262
    rs1166605991,2
    		C,F,--44869050(+) TATACG/AAAAAT 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs56191,2
    		C,F,A,H,--44869423(-) AAATTC/TGCTGG 1 -- ut31 ese321Minor allele frequency- T:0.18MN NS EA NA WA CSA 2295
    rs56181,2
    		F--44869534(-) tgcccG/Agccta 1 -- ut312Minor allele frequency- A:0.05MN 264
    rs56171,2
    		C,F--44869546(-) catgaG/Accacc 1 -- ut312Minor allele frequency- A:0.09MN 264
    rs56151,2
    		C--44869775(-) ggagtG/Acaatg 1 -- ut314Minor allele frequency- A:0.15MN NA 268
    rs56141,2
    		C,F,--44869855(-) ATATTC/TTCCTT 1 -- ut311Minor allele frequency- T:0.05MN 68

    HapMap Linkage Disequilibrium report for PTGIS (48120411 - 48184707 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PTGIS: --
    Human Gene Mutation Database (HGMD): PTGIS

    Locus Specific Mutation Databases (LSDB): PTGIS

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTGIS
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGIS

    Disorders / Diseases
    for PTGIS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTGIS for disorders           About GeneDecksing

    OMIM gene information: 601699   
    OMIM disorders: 145500  
    20/37 diseases for PTGIS (see all 37):    About MalaCards
    myocardial infarction    atherosclerosis    patent ductus arteriosus    cholesterol
    essential hypertension    primary pulmonary hypertension    cerebral infarction    breast cancer susceptibility
    pulmonary hypertension    hypertension    papillary thyroid carcinoma    epithelial ovarian cancer
    hepatopulmonary syndrome    endometritis    spondyloarthropathy    balanitis
    adenomyosis    thrombosis    diabetes mellitus    thyroid carcinoma

    1 disease from the University of Copenhagen DISEASES database for PTGIS:
    Acute endometritis

    10/23 Novoseek disease relationships for PTGIS gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertension pulmonary 43.6 12 10359560 (2), 11034952 (2), 15541968 (2), 15049720 (1) (see all 7)
    vascular diseases 32.7 2 7488205 (1), 17164139 (1)
    shock endotoxic 29.7 1 17164139 (1)
    cerebral infarction 28.9 1 12372404 (1)
    essential hypertension 28.3 2 12924623 (1)
    lung tumor 26.8 4 19138979 (2), 15313935 (1)
    thrombosis 13 2 16186418 (1)
    myocardial infarction 12.1 5 19046748 (1), 19040046 (1), 19327107 (1), 19534932 (1)
    atherosclerosis 8.64 3 20348234 (1), 17164139 (1)
    cardiovascular diseases 8.64 12 20357747 (2), 15853702 (2), 7958234 (1), 17073611 (1) (see all 6)

    Genetic Association Database (GAD): PTGIS
    Human Genome Epidemiology (HuGE) Navigator: PTGIS (33 documents)

    Export disorders for PTGIS gene to outside databases

    Publications
    for PTGIS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGIS gene, integrated from 9 sources (see all 210):
    (articles sorted by number of sources associating them with PTGIS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. (PubMed id 18081314)1, 7, 9 Ruan K.H....Cervantes V. (2008)
    2. Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1). (PubMed id 12428676)1, 4, 9 Chevalier D....Broly F. (2002)
    3. Characterization of new mutations in the coding sequence and 5'- untranslated region of the human prostacylcin synthase gene (CYP8A1). (PubMed id 11281454)1, 2, 9 Chevalier D....Broly F. (2001)
    4. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. (PubMed id 12372404)1, 4, 9 Nakayama T....Oates J.A. (2002)
    5. Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. (PubMed id 8812456)1, 3, 9 Yokoyama C.... Tanabe T. (1996)
    6. Polymorphism of the promoter region of prostacyclin synthase gene in chronic thromboembolic pulmonary hypertension. (PubMed id 15182267)1, 4, 9 Amano S....Kuriyama T. (2004)
    7. Haplotype analysis of the prostacyclin synthase gene and essential hypertension. (PubMed id 12924623)1, 4, 9 Nakayama T....Kokubun S. (2003)
    8. Molecular cloning and expression of human prostacyclin synthase. (PubMed id 8185632)1, 2, 9 Miyata A.... Tanabe T. (1994)
    9. Genetic polymorphisms of prostacyclin synthase gene a nd cardiovascular disease. (PubMed id 20357747)1, 7, 9 Nakayama T. (2010)
    10. Polymorphism of the promoter region of prostacyclin synthase gene is not related to essential hypertension. (PubMed id 11368458)1, 4, 9 Nakayama T....Kanmatsuse K. (2001)

    External Searches for PTGIS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTGIS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5740 HGNC: 9603 AceView: PTGIS Ensembl:ENSG00000124212 euGenes: HUgn5740
    ECgene: PTGIS Kegg: 5740 H-InvDB: PTGIS

    Other Databases showing PTGIS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTGIS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGIS Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp8a1.htm

    Intellectual Property
    for PTGIS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTGIS gene:
    Search GeneIP for patents involving PTGIS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PTGIS gene

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    In Situ Hybridization Assays from
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    About This Section

     
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