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PTGIS Gene

protein-coding   GIFtS: 65
GCID: GC20M048120

Prostaglandin I2 (Prostacyclin) Synthase

  See PTGIS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin I2 (Prostacyclin) Synthase1 2     Polypeptide 11
CYP82 3 5     Subfamily A1
CYP8A12 3 5     PTGI2
Prostaglandin I2 Synthase2 3     Cytochrome P450, Family 8, Subfamily A, Polypeptide 12
PGIS2 5     Prostacyclin Synthase2
Cytochrome P4501     EC 5.3.99.43
Family 81     

External Ids:    HGNC: 96031   Entrez Gene: 57402   Ensembl: ENSG000001242127   OMIM: 6016995   UniProtKB: Q166473   

Export aliases for PTGIS gene to outside databases

Previous GC identifers: GC20M047848 GC20M048758 GC20M048805 GC20M047553 GC20M044868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTGIS Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of
sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the
conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet
aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the
development of myocardial infarction, stroke, and atherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTGIS Gene:
PTGIS (prostaglandin I2 (prostacyclin) synthase) is a protein-coding gene. Diseases associated with PTGIS include essential hypertension, and myocardial infarction. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP39A1.

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)

Gene Wiki entry for PTGIS (Prostacyclin synthase) Gene

PharmGKB "VIP" summary for PTGIS


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGIS gene promoter:
         AREB6   c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGIS promoter sequence
   Search Chromatin IP Primers for PTGIS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGIS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

PTGIS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGIS gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048120:  view genomic region     (about GC identifiers)

Start:
48,120,411 bp from pter      End:
48,184,707 bp from pter
Size:
64,297 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647 (See protein sequence)
Recommended Name: Prostacyclin synthase  
Size: 500 amino acids; 57104 Da
Cofactor: Heme group
2 PDB 3D structures from and Proteopedia for PTGIS:
2IAG (3D)        3B6H (3D)    
Secondary accessions: Q3MII8 Q9HAX2 Q9HAX3 Q9HAX4

Explore the universe of human proteins at neXtProt for PTGIS: NX_Q16647

Explore proteomics data for PTGIS at MOPED


See PTGIS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000952.1  
ENSEMBL proteins: 
 ENSP00000244043  
Reactome Protein details: Q16647

PTGIS Human Recombinant Protein Products:

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Novus Biologicals PTGIS Proteins
Novus Biologicals PTGIS Lysates
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Cloud-Clone Corp. Proteins for PTGIS

 
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antibodies-online proteins for PTGIS (6 products) 

 
antibodies-online peptides for PTGIS

PTGIS Antibody Products:

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ThermoFisher Antibodies for PTGIS
antibodies-online antibodies for PTGIS (42 products) 

PTGIS Assay Products:

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antibodies-online kits for PTGIS (26 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP8A1
CYP5, CYP7 and CYP8 families

4 InterPro protein domains:
 IPR001128 Cyt_P450
 IPR002403 Cyt_P450_E_grp-IV
 IPR024204 Cyt_P450_CYP7A1-type
 IPR027286 PTGIS

Graphical View of Domain Structure for InterPro Entry Q16647

ProtoNet protein and cluster: Q16647

1 Blocks protein domain: IPB002403 E-class P450 group IV signature

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Similarity: Belongs to the cytochrome P450 family


Find genes that share domains with PTGIS           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PTGIS_HUMAN, Q16647
Function: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)
Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
(5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate

     Genatlas biochemistry entry for PTGIS:
prostaglandin 12 synthase

     Enzyme Number (IUBMB): EC 5.3.99.41

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004497monooxygenase activity IEA--
GO:0005506iron ion binding IEA--
GO:0005515protein binding IPI--
GO:0008116prostaglandin-I synthase activity IDA--
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA--
     
Find genes that share ontologies with PTGIS           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for PTGIS:
 Increased gamma-H2AX phosphory 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ptgis):
 cardiovascular system  homeostasis/metabolism  renal/urinary system 

Find genes that share phenotypes with PTGIS           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Ptgistm1Tada for PTGIS

   genOway: Develop your customized and physiologically relevant rodent model for PTGIS

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat PTGIS using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate PTGIS (see all 43):
hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-4254 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4267 hsa-miR-4314 hsa-miR-3658
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for PTGIS
Predesigned siRNA for gene silencing in human, mouse, rat PTGIS

Gene Editing
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DNA2.0 Custom Protein Engineering Service for PTGIS

Clone
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OriGene ORF clones in mouse, rat for PTGIS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PTGIS (NM_000961)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGIS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGIS

Cell Line
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GenScript Custom overexpressing Cell Line Services for PTGIS
Browse ESI BIO Cell Lines and PureStem Progenitors for PTGIS 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGIS


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PTGIS_HUMAN, Q16647: Endoplasmic reticulum membrane; Single-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
nucleus5
plasma membrane5
extracellular4
golgi apparatus2
lysosome1
mitochondrion1
peroxisome1

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space ISS--
GO:0005634nucleus IDA--
GO:0005783endoplasmic reticulum IDA--
GO:0005789endoplasmic reticulum membrane TAS--
GO:0005901caveola IDA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PTGIS About   (see all 11)  
See pathways by source

SuperPathContained pathways About
1Arachidonic acid metabolism
Arachidonic acid metabolism0.41
HETE and HPETE biosynthesis and metabolism0.33
Arachidonic acid metabolism0.40
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.00
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
3Biological oxidations
Biological oxidations0.56
Phenytoin Pathway, Pharmacokinetics0.00
4Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts0.88
Sterols are 12-hydroxylated by CYP8B10.00
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol0.88
Synthesis of bile acids and bile salts via 24-hydroxycholesterol0.00
Bile acid and bile salt metabolism0.73
Synthesis of bile acids and bile salts via 27-hydroxycholesterol0.00
5Cytochrome P450 - arranged by substrate type
Cytochrome P450 - arranged by substrate type0.75
Eicosanoids0.00
Phase 1 - Functionalization of compounds0.75
Endogenous sterols0.00


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


3 GeneGo (Thomson Reuters) Pathways for PTGIS
    HETE and HPETE biosynthesis and metabolism
Prostaglandin 2 biosynthesis and metabolism FM
Transcription PPAR Pathway

3 BioSystems Pathways for PTGIS
    Adipogenesis
Eicosanoid Synthesis
Prostaglandin Synthesis and Regulation

Selected Reactome Pathways for PTGIS (see all 6)
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Eicosanoids
Sterols are 12-hydroxylated by CYP8B1
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol

2 PharmGKB Pathways for PTGIS
    Celecoxib Pathway, Pharmacodynamics
Phenytoin Pathway, Pharmacokinetics

2 Kegg Pathways  (Kegg details for PTGIS):
    Arachidonic acid metabolism
Metabolic pathways

    Pathway & Disease-focused RT2 Profiler PCR Array including PTGIS: 
          Endothelial Cell Biology in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for PTGIS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PTGIS (ENSP000002440434) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
InteractantInteraction Details
GeneCardExternal ID(s)
HPGDSENSP000002952564STRING: ENSP00000295256
PTGDSENSP000003606874STRING: ENSP00000360687
PTGESENSP000003423854STRING: ENSP00000342385
PTGES2ENSP000003453414STRING: ENSP00000345341
PTGS1ENSP000003546124STRING: ENSP00000354612
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Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001516prostaglandin biosynthetic process IDA--
GO:0006690icosanoid metabolic process TAS--
GO:0006805xenobiotic metabolic process TAS--
GO:0019369arachidonic acid metabolic process TAS--
GO:0019371cyclooxygenase pathway TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for PTGIS
  Browse compounds at ApexBio 

Browse Tocris compounds for PTGIS

3 HMDB Compounds for PTGIS    About this table
CompoundSynonyms CAS #PubMed Ids
Heme(protoporphyrinato)iron (see all 19)14875-96-8--
Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--
Prostaglandin I2(5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoate (see all 20)35121-78-9--

3 DrugBank Compounds for PTGIS    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Phenylbutazone-- 50-33-9targetinhibitor3917545 6434940 3517382 17139284 17016423
EpoprostenolPGI2 (see all 3)35121-78-9targetinducer20357747 18081314
(6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID-- --target--10592235

Selected Novoseek inferred chemical compound relationships for PTGIS gene (see all 29)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
prostacyclin 94.4 476 8051072 (7), 12019369 (6), 18835932 (6), 8034007 (5) (see all 99)
prostaglandin-h2 90.7 44 18590695 (3), 16406803 (3), 11006279 (2), 18032380 (2) (see all 18)
pgh2 78.8 9 9721692 (1), 15370068 (1), 18081314 (1), 12512699 (1) (see all 7)
thromboxane a2 78 36 9367522 (2), 12738712 (2), 8263161 (1), 11006279 (1) (see all 19)
6-ketoprostaglandin f1alpha 77.4 10 9933282 (2), 8263161 (1), 12019369 (1), 19040046 (1) (see all 7)
thromboxane 77.2 26 11756341 (2), 17189713 (2), 8051072 (1), 12154203 (1) (see all 18)
peroxynitrite 70.1 22 9278151 (3), 10335439 (3), 14504187 (2), 17164139 (2) (see all 14)
arachidonic acid 65.7 28 16537708 (2), 15708381 (2), 17115695 (2), 18835243 (2) (see all 10)
dodecylphosphocholine 64.3 2 12590920 (1)
prostaglandin 62.7 17 15115769 (1), 19046748 (1), 16537708 (1), 19327107 (1) (see all 6)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PTGIS gene: 
NM_000961.3  

Unigene Cluster for PTGIS:

Prostaglandin I2 (prostacyclin) synthase
Hs.302085  [show with all ESTs]
Unigene Representative Sequence: NM_000961
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000244043(uc002xut.3 uc010zyi.2) ENST00000478971
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate PTGIS (see all 43):
hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-4254 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4267 hsa-miR-4314 hsa-miR-3658
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Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: PTGIS (NM_000961)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGIS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGIS
Primer
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OriGene qPCR primer pairs and template standards for PTGIS
OriGene qSTAR qPCR primer pairs in human, mouse for PTGIS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTGIS
  QuantiTect SYBR Green Assays in human, mouse, rat PTGIS
  QuantiFast Probe-based Assays in human, mouse, rat PTGIS

Additional mRNA sequence: 

AF297048.1 AF297049.1 AF297050.1 AF297051.1 AF297052.1 AK055640.1 BC101809.1 BC101811.1 
BC143381.1 D38145.1 

2 DOTS entries:

DT.306642  DT.312136 

Selected AceView cDNA sequences (see all 65):

CD014146 AA083871 AA150210 AF297049 CD014051 BP374626 BG747647 AF297048 
F04077 NM_000961 AF297051 AA126676 AF297052 BI913761 AA112885 CA415428 
AI969383 BE466814 AL700270 D38145 AF297050 BE674368 CA406151 AA148801 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PTGIS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PTGIS Expression
About this image


PTGIS expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Membranous Facial Bones
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Kidney (Urinary System)
         Renal Vesicle
 
 Blood (Cardiovascular System)
         Conventional Dendritic Cells I Spleen
 
 Brain (Nervous System)
         Medulla Oblongata
PTGIS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PTGIS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.302085

UniProtKB/Swiss-Prot: PTGIS_HUMAN, Q16647
Tissue specificity: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate

    Pathway & Disease-focused RT2 Profiler PCR Array including PTGIS: 
          Endothelial Cell Biology in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for PTGIS
OriGene qSTAR qPCR primer pairs in human, mouse for PTGIS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTGIS
QuantiTect SYBR Green Assays in human, mouse, rat PTGIS
QuantiFast Probe-based Assays in human, mouse, rat PTGIS
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGIS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PTGIS gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ptgis1 , 5 prostaglandin I2 (prostacyclin) synthase1, 5 84.31(n)1
86.04(a)1
  2 (87.22 cM)5
192231  NM_008968.31  NP_032994.11 
 1671918055 
lizard
(Anolis carolinensis)
Reptilia PTGIS6
prostaglandin I2 (prostacyclin) synthase
58(a)
1 ↔ 1
4(146807129-146853188)
tropical clawed frog
(Xenopus tropicalis)
Amphibia ptgis1 prostaglandin I2 (prostacyclin) synthase 59.86(n)
56.84(a)
  100492372  XM_002933182.2  XP_002933228.2 
zebrafish
(Danio rerio)
Actinopterygii ptgis1 prostaglandin I2 (prostacyclin) synthase 55.41(n)
49.78(a)
  559148  NM_001111160.1  NP_001104630.1 


ENSEMBL Gene Tree for PTGIS (if available)
TreeFam Gene Tree for PTGIS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PTGIS gene
CYP39A12  CYP7A12  CYP7B12  CYP8B12  
4 SIMAP similar genes for PTGIS using alignment to 3 protein entries:     PTGIS_HUMAN (see all proteins):
PGIS    CYP8B1    CYP7A1    CYP7B1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PTGIS (see all 1580)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1475347091,2
C,Funtested148101908(+) AGAAGG/AAAGAG 2 /F syn11Minor allele frequency- A:0.00NA 4552
rs1422130011,2
C--44925028(+) TACAC-/TTTTTTT 1 -- int10--------
rs1391814611,2
C--48090941(+) AGTGAC/TGGGGA 1 -- ds50010--------
rs5741131,2
C,F,A,H--48091199(-) TGCCCA/GAGAAC 1 -- ds500130Minor allele frequency- G:0.27NS EA NA WA CSA 2777
rs1179908361,2
C,F--48091233(+) CAGTTT/GCTTTC 1 -- ds50011Minor allele frequency- G:0.02NA 120
rs1156594211,2
C,F--48091245(+) CTGTAA/GAAACG 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs1499670731,2
C--48091249(+) AAAAAC/TGGGGA 1 -- ds50010--------
rs757775271,2
C,F--48091370(+) GAGCTG/TACCTC 1 -- ds50011Minor allele frequency- T:0.03WA 118
rs5719071,2
C,F,H--48091390(-) TTGGCC/TGTGCC 1 -- ds500114Minor allele frequency- T:0.08NS EA NA CSA WA 1884
rs1839501271,2
--48091428(+) GCAGTC/TCCACA 1 -- ut310--------

HapMap Linkage Disequilibrium report for PTGIS (48120411 - 48184707 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for PTGIS: --
The Human Cytochrome P450 Allele Nomenclature Database: PTGIS 
Human Gene Mutation Database (HGMD): PTGIS
Locus Specific Mutation Databases (LSDB): PTGIS

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PTGIS
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601699   
OMIM disorders: 145500  
3 diseases for PTGIS:    
About MalaCards
essential hypertension    myocardial infarction    atherosclerosis

1 disease from the University of Copenhagen DISEASES database for PTGIS:
Hypertension

Find genes that share disorders with PTGIS           About GenesLikeMe

Selected Novoseek inferred disease relationships for PTGIS gene (see all 23)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hypertension pulmonary 43.6 12 10359560 (2), 11034952 (2), 15541968 (2), 15049720 (1) (see all 7)
vascular diseases 32.7 2 7488205 (1), 17164139 (1)
shock endotoxic 29.7 1 17164139 (1)
cerebral infarction 28.9 1 12372404 (1)
essential hypertension 28.3 2 12924623 (1)
lung tumor 26.8 4 19138979 (2), 15313935 (1)
thrombosis 13 2 16186418 (1)
myocardial infarction 12.1 5 19046748 (1), 19040046 (1), 19327107 (1), 19534932 (1)
atherosclerosis 8.64 3 20348234 (1), 17164139 (1)
cardiovascular diseases 8.64 12 20357747 (2), 15853702 (2), 7958234 (1), 17073611 (1) (see all 6)

Genetic Association Database (GAD): PTGIS
Human Genome Epidemiology (HuGE) Navigator: PTGIS (33 documents)

Export disorders for PTGIS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PTGIS gene, integrated from 10 sources (see all 215):
(articles sorted by number of sources associating them with PTGIS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. (PubMed id 18081314)1, 7, 9 Ruan K.H....Cervantes V. (Biochemistry 2008)
  2. Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. (PubMed id 16537708)1, 4, 9 Poole E.M....Ulrich C.M. (amp 2006)
  3. Crystal structure of the human prostacyclin synthase. (PubMed id 17020766)1, 2, 9 Chiang C.W.... Chan N.L. (J. Mol. Biol. 2006)
  4. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. (PubMed id 19327107)1, 4, 9 Xie X....Liu F. (Clin. Chem. Lab. Med. 2009)
  5. Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1). (PubMed id 12428676)1, 4, 9 Chevalier D....Broly F. (amp 2002)
  6. Characterization of new mutations in the coding sequence and 5'- untranslated region of the human prostacyclin synthase gene (CYP8A1). (PubMed id 11281454)1, 2, 9 Chevalier D....Broly F. (Hum. Genet. 2001)
  7. [Study on the association of cyclooxygenase-2 -765g&gt;C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China]. (PubMed id 19040046)1, 4, 9 Xie X....Liu F. (Zhonghua Liu Xing Bing Xue Za Zhi 2008)
  8. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. (PubMed id 12372404)1, 4, 9 Nakayama T....Oates J.A. (Biochem. Biophys. Res. Commun. 2002)
  9. Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. (PubMed id 8812456)1, 3, 9 Yokoyama C.... Tanabe T. (Genomics 1996)
  10. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4, 9 Lemaitre R.N....Psaty B.M. (Atherosclerosis 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5740 HGNC: 9603 AceView: PTGIS Ensembl:ENSG00000124212 euGenes: HUgn5740
ECgene: PTGIS Kegg: 5740 H-InvDB: PTGIS

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PTGIS Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PTGIS Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp8a1.htm

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PTGIS gene:
Search GeneIP for patents involving PTGIS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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