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Aliases for PTGIS Gene

Aliases for PTGIS Gene

  • Prostaglandin I2 Synthase 2 3 4 5
  • Cytochrome P450, Family 8, Subfamily A, Polypeptide 1 2 3
  • Prostaglandin I2 (Prostacyclin) Synthase 2 3
  • Prostacyclin Synthase 2 3
  • CYP8A1 3 4
  • CYP8 3 4
  • EC 4
  • PGIS 3
  • PTGI 3

External Ids for PTGIS Gene

Previous GeneCards Identifiers for PTGIS Gene

  • GC20M047848
  • GC20M048758
  • GC20M048805
  • GC20M047553
  • GC20M048120
  • GC20M044868

Summaries for PTGIS Gene

Entrez Gene Summary for PTGIS Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGIS Gene

PTGIS (Prostaglandin I2 Synthase) is a Protein Coding gene. Diseases associated with PTGIS include Hypertension, Essential and Atherosclerosis. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP8B1.

UniProtKB/Swiss-Prot for PTGIS Gene

  • Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

Gene Wiki entry for PTGIS Gene

PharmGKB "VIP" Summary for PTGIS Gene

Additional gene information for PTGIS Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for PTGIS Gene

Genomics for PTGIS Gene

Regulatory Elements for PTGIS Gene

Enhancers for PTGIS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H049604 1.3 FANTOM5 ENCODE dbSUPER 22.4 -37.2 -37211 1.8 ELF3 SOX13 DRAP1 FOXA2 SAP130 NFIB THRB TEAD3 GATA3 LCORL PTGIS KCNB1 RNF114 B4GALT5 LOC105372651 GC20M049629
GH20H049275 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +288.2 288216 9.2 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC DDX27 CSE1L ZNFX1 SNORD12B ZFAS1 B4GALT5 RNF114 ARFGEF2 PTGIS KRT18P4
GH20H049582 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -16.4 -16350 3.1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 MXD4 PTGIS KCNB1 RNU6-919P SLC9A8 LOC105372651
GH20H050496 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -929.8 -929801 3.7 ATF1 ZBTB40 BATF ETS1 ELK1 ZNF143 FOS ATF7 RUNX3 CREM ENSG00000232043 PTPN1 PTGIS CEBPB MIR645 MIR1302-5 RPL36P2 LOC101927512 PARD6B TMEM189
GH20H049342 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +222.9 222918 5.7 TBP PKNOX1 ZNF133 SIN3A BMI1 ZEB1 RFX5 SMARCC2 FOS RCOR1 KCNB1 PTGIS ZFAS1 STAU1 GC20M049341 GC20M049348
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTGIS on UCSC Golden Path with GeneCards custom track

Promoters for PTGIS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for PTGIS Gene

Genomic Locations for PTGIS Gene
64,297 bases
Minus strand

Genomic View for PTGIS Gene

Genes around PTGIS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGIS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGIS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGIS Gene

Proteins for PTGIS Gene

  • Protein details for PTGIS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prostacyclin synthase
    Protein Accession:
    Secondary Accessions:
    • Q3MII8
    • Q9HAX2
    • Q9HAX3
    • Q9HAX4

    Protein attributes for PTGIS Gene

    500 amino acids
    Molecular mass:
    57104 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTGIS Gene

neXtProt entry for PTGIS Gene

Post-translational modifications for PTGIS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGIS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PTGIS (Prostaglandin I2 Synthase)
  • Abcam antibodies for PTGIS

No data available for DME Specific Peptides for PTGIS Gene

Domains & Families for PTGIS Gene

Gene Families for PTGIS Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for PTGIS Gene

Suggested Antigen Peptide Sequences for PTGIS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with PTGIS: view

Function for PTGIS Gene

Molecular function for PTGIS Gene

GENATLAS Biochemistry:
prostaglandin 12 synthase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=9.55 uM for 6-keto-PGF1alpha {ECO:0000269 PubMed:25623425}; KM=13 uM for prostaglandin H2 (at 23 degrees Celsius) {ECO:0000269 PubMed:18032380}; Vmax=534 mmol/min/pg enzyme {ECO:0000269 PubMed:25623425}; Vmax=980 mol/min/mol enzyme {ECO:0000269 PubMed:18032380};
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function:
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

Enzyme Numbers (IUBMB) for PTGIS Gene

Phenotypes From GWAS Catalog for PTGIS Gene

Gene Ontology (GO) - Molecular Function for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 20122998
GO:0008116 prostaglandin-I synthase activity TAS --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with PTGIS: view
genes like me logo Genes that share phenotypes with PTGIS: view

Human Phenotype Ontology for PTGIS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTGIS Gene

MGI Knock Outs for PTGIS:

Animal Model Products

miRNA for PTGIS Gene

miRTarBase miRNAs that target PTGIS

Inhibitory RNA Products

No data available for Transcription Factor Targets and HOMER Transcription for PTGIS Gene

Localization for PTGIS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGIS Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGIS gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005634 nucleus IDA,IEA 21035466
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA,IDA 21035466
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PTGIS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGIS Gene

Pathways & Interactions for PTGIS Gene

genes like me logo Genes that share pathways with PTGIS: view

Gene Ontology (GO) - Biological Process for PTGIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 20122998
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006690 icosanoid metabolic process TAS --
genes like me logo Genes that share ontologies with PTGIS: view

No data available for SIGNOR curated interactions for PTGIS Gene

Drugs & Compounds for PTGIS Gene

(13) Drugs for PTGIS Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenylbutazone Approved, Vet_approved Pharma inhibitor, Target 0
Epoprostenol Approved Pharma Target, inducer 54
(5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid Experimental Pharma Target 0
heme Pharma Agonist 0

(21) Additional Compounds for PTGIS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,13E)-(15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dienoate
genes like me logo Genes that share compounds with PTGIS: view

Transcripts for PTGIS Gene

mRNA/cDNA for PTGIS Gene

Unigene Clusters for PTGIS Gene

Prostaglandin I2 (prostacyclin) synthase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGIS Gene

No ASD Table

Relevant External Links for PTGIS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTGIS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGIS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGIS Gene

This gene is overexpressed in Artery - Coronary (x5.8), Artery - Aorta (x5.8), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for PTGIS Gene

This gene is overexpressed in Urinary Bladder (12.9), Testis (11.5), and Uterus (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTGIS Gene

Protein tissue co-expression partners for PTGIS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGIS Gene:


SOURCE GeneReport for Unigene cluster for PTGIS Gene:


mRNA Expression by UniProt/SwissProt for PTGIS Gene:

Tissue specificity: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.

Evidence on tissue expression from TISSUES for PTGIS Gene

  • Nervous system(4.3)
  • Heart(2.8)
  • Muscle(2.5)
  • Lung(2.1)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGIS Gene

Germ Layers:
  • mesoderm
  • cardiovascular
Head and neck:
  • ear
  • heart
  • blood
  • blood vessel
genes like me logo Genes that share expression patterns with PTGIS: view

Orthologs for PTGIS Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGIS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTGIS 33 34
  • 98.68 (n)
(Bos Taurus)
Mammalia PTGIS 33 34
  • 87.2 (n)
(Canis familiaris)
Mammalia PTGIS 33 34
  • 86.85 (n)
(Mus musculus)
Mammalia Ptgis 33 16 34
  • 84.31 (n)
(Rattus norvegicus)
Mammalia Ptgis 33
  • 82.43 (n)
(Monodelphis domestica)
Mammalia PTGIS 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia PTGIS 34
  • 65 (a)
(Anolis carolinensis)
Reptilia PTGIS 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgis 33
  • 59.86 (n)
(Danio rerio)
Actinopterygii ptgis 33 34
  • 55.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4049 34
  • 34 (a)
-- 34
  • 30 (a)
Species where no ortholog for PTGIS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGIS Gene

Gene Tree for PTGIS (if available)
Gene Tree for PTGIS (if available)

Paralogs for PTGIS Gene

Paralogs for PTGIS Gene

(4) SIMAP similar genes for PTGIS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTGIS: view

Variants for PTGIS Gene

Sequence variations from dbSNP and Humsavar for PTGIS Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs61734270 Likely pathogenic 49,524,089(+) GGGCC(C/T)GTGCC reference, missense
rs1000041854 -- 49,566,793(+) ATGTG(A/G)TAACT intron-variant, upstream-variant-2KB
rs1000108429 -- 49,527,718(+) CTGAA(G/T)TATAC intron-variant
rs1000141289 -- 49,520,128(+) TCCGG(C/G)AGCTC intron-variant
rs1000166373 -- 49,503,779(+) AAGGG(A/G)CAGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PTGIS Gene

Variant ID Type Subtype PubMed ID
nsv586176 CNV loss 21841781
nsv586175 CNV loss 21841781
nsv586174 CNV loss 21841781
nsv586173 CNV loss 21841781
nsv1065852 CNV loss 25217958
esv3646015 CNV loss 21293372
esv3568005 CNV loss 25503493
esv2762080 CNV loss 21179565
dgv4323n100 CNV loss 25217958

Variation tolerance for PTGIS Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGIS Gene

Human Gene Mutation Database (HGMD)
The Human Cytochrome P450 Allele Nomenclature Database
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGIS Gene

Disorders for PTGIS Gene

MalaCards: The human disease database

(10) MalaCards diseases for PTGIS Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertension, essential
  • hypertension, essential 3
  • arteriosclerosis
myocardial infarction
  • myocardial infarction, protection against
stroke, ischemic
  • ischemic stroke
female stress incontinence
  • female urinary stress incontinence
- elite association - COSMIC cancer census association via MalaCards
Search PTGIS in MalaCards View complete list of genes associated with diseases


  • Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269 PubMed:12372404}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for PTGIS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTGIS: view

No data available for Genatlas for PTGIS Gene

Publications for PTGIS Gene

  1. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. (PMID: 12372404) Nakayama T … Oates JA (Biochemical and biophysical research communications 2002) 3 4 22 45 60
  2. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 22 45 60
  3. A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate. (PMID: 19265782) Barbalić M … Rudan P (American journal of hypertension 2009) 3 22 45 60
  4. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. (PMID: 19327107) Xie X … Liu F (Clinical chemistry and laboratory medicine 2009) 3 22 45 60
  5. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PMID: 19336370) Dagle JM … Murray JC (Pediatrics 2009) 3 22 45 60

Products for PTGIS Gene

Sources for PTGIS Gene

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