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PTGIR Gene

protein-coding   GIFtS: 69
GCID: GC19M047123

Prostaglandin I2 (Prostacyclin) Receptor (IP)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin I2 (Prostacyclin) Receptor (IP)1 2     PGI Receptor2 3
Prostaglandin I2 Receptor2 3     PGI2 Receptor2 3
Prostanoid IP Receptor2 3     IP2
PRIPR2 3     Prostacyclin Receptor2

External Ids:    HGNC: 96021   Entrez Gene: 57392   Ensembl: ENSG000001600137   OMIM: 6000225   UniProtKB: P431193   

Export aliases for PTGIR gene to outside databases

Previous GC identifers: GC19M047767 GC19M047514 GC19M051799 GC19M051815 GC19M043548


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTGIR Gene:
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a
receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium,
elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. (provided
by RefSeq, Jul 2008)

GeneCards Summary for PTGIR Gene:
PTGIR (prostaglandin I2 (prostacyclin) receptor (IP)) is a protein-coding gene. Diseases associated with PTGIR include arteriosclerosis obliterans, and arteriosclerosis. GO annotations related to this gene include G-protein coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot: PI2R_HUMAN, P43119
Function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s)
proteins which activate adenylate cyclase

summary for PTGIR Gene:
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. IP receptors are coupled to Galphas and are
involved in pain mediation, relaxation of vascular smooth muscle, inhibition of platelet aggregation and
they contribute to cardiovascular health.

Gene Wiki entry for PTGIR (Prostacyclin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGIR gene promoter:
         MEF-2   SREBP-1c   AP-4   SREBP-1b   MEF-2A   PPAR-gamma1   SREBP-1a   SEF-1 (1)   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGIR promoter sequence
   Search Chromatin IP Primers for PTGIR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGIR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

PTGIR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGIR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047123:  view genomic region     (about GC identifiers)

Start:
47,123,725 bp from pter      End:
47,128,375 bp from pter
Size:
4,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PI2R_HUMAN, P43119 (See protein sequence)
Recommended Name: Prostacyclin receptor precursor  
Size: 386 amino acids; 40956 Da
Subunit: Interacts (non-isoprenylated C-terminus) with PDZK1 (By similarity)

Explore the universe of human proteins at neXtProt for PTGIR: NX_P43119

Explore proteomics data for PTGIR at MOPED

Post-translational modifications: 

  • Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling1
  • Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl
    cyclase and phospholipase C1
  • Glycosylation2 at Asn7
  • Modification sites at PhosphoSitePlus

  • See PTGIR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000951.1  
    ENSEMBL proteins: 
     ENSP00000291294   ENSP00000470566   ENSP00000470799   ENSP00000469408   ENSP00000468970  
    Reactome Protein details: P43119

    PTGIR Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PTGIR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PTGIR
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    Novus Biologicals PTGIR Proteins
    Novus Biologicals PTGIR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGIR

    PTGIR Antibody Products:

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    PTGIR Assay Products:

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    GenScript PTGIR-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for PTGIR
    Cloud-Clone Corp. CLIAs for PTGIR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTGR: GPCR / Class A : Prostanoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: IP1 receptor
    Prostanoid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008365 Prostanoid_rcpt
     IPR000370 Prostglndn_IP_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P43119

    ProtoNet protein and cluster: P43119

    1 Blocks protein domain: IPB000370 Prostacyclin (prostanoid IP) receptor signature

    UniProtKB/Swiss-Prot: PI2R_HUMAN, P43119
    Similarity: Belongs to the G-protein coupled receptor 1 family


    PTGIR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI2R_HUMAN, P43119
    Function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s)
    proteins which activate adenylate cyclase

         Genatlas biochemistry entry for PTGIR:
    protaglandin 12 (prostacyclin) receptor,subtype IP,expressed in the cardiovascular system,G protein coupled
    receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
         
    PTGIR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTGIR:
     Decreased G3BP1 protein expres 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ptgir):
     behavior/neurological  cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  tumorigenesis 

    PTGIR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptgirtm1Sna for PTGIR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTGIR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PTGIR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGIR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGIR

    miRNA
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    Block miRNA regulation of human, mouse, rat PTGIR using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate PTGIR:
    hsa-miR-3134 hsa-miR-331-3p hsa-miR-608 hsa-miR-1193 hsa-miR-3155 hsa-miR-3155b hsa-miR-484
    SwitchGear 3'UTR luciferase reporter plasmidPTGIR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PTGIR
    Predesigned siRNA for gene silencing in human, mouse, rat PTGIR

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PTGIR (see all 8)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGIR (NM_000960)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGIR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGIR

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PTGIR 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGIR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PI2R_HUMAN, P43119: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    extracellular2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7512962
    GO:0016021integral component of membrane ----

    PTGIR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTGIR About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Eicosanoid ligand-binding receptors
    Eicosanoid ligand-binding receptors0.31
    Prostanoid ligand receptors0.00
    Small Ligand GPCRs0.31
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4ADP signalling through P2Y purinoceptor 12
    Prostacyclin signalling through prostacyclin receptor0.79
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PTGIR
        Renin-Angiotensin Pathway
    PPAR Pathway

    1 GeneGo (Thomson Reuters) Pathway for PTGIR
        Development PDGF signaling via MAPK cascades

    5 BioSystems Pathways for PTGIR
        Prostaglandin Synthesis and Regulation
    GPCRs, Class A Rhodopsin-like
    Endothelin
    Thromboxane A2 receptor signaling
    Small Ligand GPCRs

    3 Reactome Pathways for PTGIR
        Prostanoid ligand receptors
    Prostacyclin signalling through prostacyclin receptor
    G alpha (s) signalling events

    2 PharmGKB Pathways for PTGIR
        Celecoxib Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for PTGIR):
        Neuroactive ligand-receptor interaction
    Vascular smooth muscle contraction


    PTGIR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTGIR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTGIR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTGIR (P431193 ENSP000002912944) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    GNASQ5JWF23, ENSP000003601414I2D: score=2 STRING: ENSP00000360141
    ADCY10Q96PN63, ENSP000003568254I2D: score=1 STRING: ENSP00000356825
    GNA11P299923, ENSP000000784294I2D: score=2 STRING: ENSP00000078429
    PDE6DO439243, ENSP000002876004I2D: score=2 STRING: ENSP00000287600
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7512962
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP--
    GO:0007267cell-cell signaling TAS7512962
    GO:0007596blood coagulation TAS--

    PTGIR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PTGIR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IloprostProstacyclin (PGI2) analog[78919-13-8]
    L-798,106 Potent and highly selective EP3 antagonist[244101-02-8]
    U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]
    Prostaglandin E2Major endogenous prostanoid[363-24-6]
    L-161,982 Selective EP4 receptor antagonist[147776-06-5]

    1 HMDB Compound for PTGIR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Prostaglandin I2(5Z,13E)-(15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoate (see all 20)35121-78-9--

    4 DrugBank Compounds for PTGIR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Iloprost-- 78919-13-8targetagonist20395700 1375507 17273558 2456096 19475782 11792366 17257398 19683911 15163595
    EpoprostenolPGI2 (see all 3)35121-78-9targetagonist12297509 11752352 19302827 20522800
    Treprostinil-- 81846-19-7targetagonist11752352 18574748 15163595 20622039
    Dinoprost TromethamineDinoprost, trometamol salt (see all 7)38562-01-5targetantagonist17139284 11752352 17016423

    Selected IUPHAR Ligands for PTGIR (IP1 receptor) (see all 18)    About this table
    LigandTypeActionAffinityPubmed IDs
    BAY-73-1449
    AntagonistAntagonist1018603238
    taprostene
    AgonistPartial agonist9.1122480736
    [3H]iloprost
    AgonistFull agonist7.7 - 916604093 10634944 7512962
    RO1138452
    AntagonistAntagonist8.716331286
    AFP-07
    AgonistFull agonist8.59112287
    TEI-9063
    AgonistFull agonist8.59156364
    FK-788
    AgonistFull agonist8.0515914004
    BMY 45778
    AgonistFull agonist89156364
    iloprost
    AgonistFull agonist7.5 - 816604093 10634944
    cicaprost
    AgonistFull agonist7.810634944

    Selected Novoseek inferred chemical compound relationships for PTGIR gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iloprost 94.3 40 15053924 (4), 10446129 (2), 7538756 (1), 8836153 (1) (see all 23)
    prostacyclin 93.7 316 9072386 (6), 18323528 (5), 9264479 (5), 7923647 (5) (see all 99)
    cicaprost 93.5 13 10446129 (2), 10827090 (1), 8448599 (1), 7532011 (1) (see all 10)
    octimibate 90.3 10 1710526 (3), 2043927 (3), 2175792 (1), 11583920 (1)
    carbacyclin 81.9 5 15194446 (1), 19122175 (1), 12576509 (1), 8289201 (1)
    pgd2 76.5 7 17943472 (1), 19235054 (1), 10799648 (1), 11943879 (1) (see all 6)
    thromboxane a2 75.1 19 16078846 (2), 16271145 (2), 10827090 (1), 7492609 (1) (see all 12)
    butaprost 72.2 3 15985651 (1), 14752026 (1)
    prostaglandin 67.6 14 7532011 (1), 15978581 (1), 7492609 (1), 9561143 (1) (see all 9)
    thromboxane 63.7 6 9341156 (1), 12598419 (1), 16078846 (1), 17110599 (1) (see all 5)



    PTGIR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PTGIR gene: 
    NM_000960.3  

    Unigene Cluster for PTGIR:

    Prostaglandin I2 (prostacyclin) receptor (IP)
    Hs.458324  [show with all ESTs]
    Unigene Representative Sequence: BC075814
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291294(uc002pex.3) ENST00000597185 ENST00000598865 ENST00000594275
    ENST00000595460 ENST00000596260
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate PTGIR:
    hsa-miR-3134 hsa-miR-331-3p hsa-miR-608 hsa-miR-1193 hsa-miR-3155 hsa-miR-3155b hsa-miR-484
    SwitchGear 3'UTR luciferase reporter plasmidPTGIR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTGIR
    Clone
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    GenScript: all cDNA clones in your preferred vector: PTGIR (NM_000960)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGIR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGIR
    Primer
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    OriGene qPCR primer pairs and template standards for PTGIR
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      QuantiTect SYBR Green Assays in human, mouse, rat PTGIR
      QuantiFast Probe-based Assays in human, mouse, rat PTGIR

    Additional mRNA sequence: 

    AK315278.1 AY242134.1 BC075814.1 BC110342.1 D25418.1 D29634.1 L29016.1 

    3 DOTS entries:

    DT.95262516  DT.100682394  DT.121438577 

    Selected AceView cDNA sequences (see all 38):

    AY242134 BQ185457 CR601077 CD013873 BC017857 AW139745 CD013874 D25418 
    CD013872 NM_000960 T27938 BM273260 BM354213 AW004015 D29634 L29016 
    BX327968 CK820124 AL552324 BM925058 AA861623 AU132613 BX102333 CF131282 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PTGIR    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c
    SP1:        -                       -               
    SP2:        -     -                 -               
    SP3:        -     -     -           -               
    SP4:              -     -     -                     


    ECgene alternative splicing isoforms for PTGIR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTGIR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGGTAC
    PTGIR Expression
    About this image


    PTGIR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 22 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
    PTGIR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTGIR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458324
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PTGIR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTGIR gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgir1 , 5 prostaglandin I receptor (IP)1, 5 80.09(n)1
    79.48(a)1
      7 (9.15 cM)5
    192221  NM_008967.31  NP_032993.21 
     169064905 
    lizard
    (Anolis carolinensis)
    Reptilia PTGIR6
    prostaglandin I2 (prostacyclin) receptor (IP)
    50(a)
    1 ↔ 1
    GL343568.1(413014-415146)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptgir1 prostaglandin I2 (prostacyclin) receptor (IP) 55.81(n)
    56.74(a)
      100490183  XM_002932631.2  XP_002932677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5614061 prostacyclin receptor-like 59.43(n)
    52.49(a)
      561406  XM_684811.5  XP_689903.3 


    ENSEMBL Gene Tree for PTGIR (if available)
    TreeFam Gene Tree for PTGIR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTGIR gene
    PTGER12  PTGDR2  PTGER42  PTGER32  PTGFR2  PTGER22  TBXA2R2  
    4 SIMAP similar genes for PTGIR using alignment to 5 protein entries:     PI2R_HUMAN (see all proteins):
    PTGFR    PTGER2    PTGDR    PTGER4

    PTGIR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTGIR (see all 312)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580794571,2
    C--47123254(+) AAGCCT/GGTGTG 1 -- ds50015Minor allele frequency- G:0.20CSA WA NA EA 361
    rs1149385841,2
    F--47123267(+) TGGCAG/AGCTGG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1454134361,2
    --47123283(+) ACCCCG/TGCAGG 1 -- ds50010--------
    rs1832924471,2
    --47123335(+) GGCAAC/TCAGCA 1 -- ds50010--------
    rs42674381,2
    C,F,A,H--47123402(+) GTCACT/GCCGTC 1 -- ds500114Minor allele frequency- G:0.13NS EA NA WA CSA 782
    rs1891319381,2
    --47123433(+) CTCACG/TGCAGC 1 -- ds50010--------
    rs1381439801,2
    --47123460(+) CAGGTA/GATCCT 1 -- ds50010--------
    rs2009913101,2
    --47123533(+) TAAAA-/TTTTTT 1 -- ds50010--------
    rs1926046751,2
    --47123597(+) CAAGGC/GATCCT 1 -- ds50010--------
    rs1833160331,2
    --47123628(+) TGCTGA/GGATTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PTGIR (47123725 - 47128375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PTGIR:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3961n71CNV Loss21882294
    nsv833849CNV Loss17160897

    Human Gene Mutation Database (HGMD): PTGIR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGIR
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGIR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600022    OMIM disorders: --

    Selected diseases for PTGIR (see all 28):    
    About MalaCards
    arteriosclerosis obliterans    arteriosclerosis    cholera    primary pulmonary hypertension
    venous thrombosis    autism spectrum disorder    eclampsia    cystic fibrosis
    pre-eclampsia    pertussis    blindness    neuroblastoma
    hypertension    atherosclerosis    coronary artery disease    asthma
    hepatitis b    inflammatory bowel disease    cerebritis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for PTGIR:
    Hypertension     Arteriosclerosis obliterans

    PTGIR for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PTGIR gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 55 2 15979846 (1), 18755267 (1)
    glioma 30.4 4 7525345 (1), 7982493 (1), 1379045 (1), 8306980 (1)
    acidosis 15.7 2 11577779 (1), 11854299 (1)
    restenosis 14.2 1 17164137 (1)
    cholera 10.3 1 9687565 (1)
    inflammation 10 6 19122175 (1)
    atherosclerosis 4.56 2 17164137 (1), 18323528 (1)
    cardiovascular diseases 0 3 18323528 (1), 9072386 (1), 7923647 (1)
    leukemia 0 2 7514139 (1), 11682632 (1)
    arthritis 0 2 16446378 (1)

    Genetic Association Database (GAD): PTGIR
    Human Genome Epidemiology (HuGE) Navigator: PTGIR (11 documents)

    Export disorders for PTGIR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTGIR gene, integrated from 10 sources (see all 213):
    (articles sorted by number of sources associating them with PTGIR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. (PubMed id 15194446)1, 2, 9 Giguere V.... Parent J.-L. (Eur. J. Pharmacol. 2004)
    2. Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. (PubMed id 12488443)1, 2, 9 Miggin S.M.... Kinsella B.T. (J. Biol. Chem. 2003)
    3. Cloning and expression of a cDNA for the human prostanoid IP receptor. (PubMed id 7512962)1, 2, 9 Boie Y.... Abramovitz M. (J. Biol. Chem. 1994)
    4. Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. (PubMed id 7923647)1, 2, 9 Nakagawa O.... Nakao K. (Circulation 1994)
    5. Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. (PubMed id 11895442)1, 2, 9 Miggin S.M.... Kinsella B.T. (Eur. J. Biochem. 2002)
    6. Cloning and expression of a cDNA for the human prostacyclin receptor. (PubMed id 7514139)1, 2, 9 Katsuyama M....Ichikawa A. (FEBS Lett. 1994)
    7. Chromosomal localization of the human prostanoid receptor gene family. (PubMed id 7759114)1, 3, 9 Duncan A.M....Adam M. (Genomics 1995)
    8. Structural organization and chromosomal assignment of the human prostacyclin receptor gene. (PubMed id 7665161)1, 2, 9 Ogawa Y.... Narumiya S. (Genomics 1995)
    9. Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease. (PubMed id 20522800)1, 7 Ibrahim S....Smyth E.M. (Arterioscler. Thromb. Vasc. Biol. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5739 HGNC: 9602 AceView: PTGIR Ensembl:ENSG00000160013 euGenes: HUgn5739
    ECgene: PTGIR Kegg: 5739 H-InvDB: PTGIR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTGIR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTGIR gene:
    Search GeneIP for patents involving PTGIR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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