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PTGFRN Gene

protein-coding   GIFtS: 60
GCID: GC01P117452

Prostaglandin F2 Receptor Inhibitor

(Previous name: prostaglandin F2 receptor negative regulator)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin F2 Receptor Inhibitor1 2     CD9 Partner 12 3
FPRP2 3 5     CD3152
Prostaglandin F2 Receptor Negative Regulator1 2     SMAP-62
Glu-Trp-Ile EWI Motif-Containing Protein F2 3     CD9P13
Prostaglandin F2-Alpha Receptor Regulatory Protein2 3     EWIF3
Prostaglandin F2-Alpha Receptor-Associated Protein2 3     KIAA14363
CD9P-12 3     CD315 Antigen3
EWI-F2 3     

External Ids:    HGNC: 96011   Entrez Gene: 57382   Ensembl: ENSG000001342477   OMIM: 6012045   UniProtKB: Q9P2B23   

Export aliases for PTGFRN gene to outside databases

Previous GC identifers: GC01P117943 GC01P116322 GC01P116600 GC01P116796 GC01P116799 GC01P117164 GC01P117254 GC01P115311


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PTGFRN Gene:
PTGFRN (prostaglandin F2 receptor inhibitor) is a protein-coding gene. An important paralog of this gene is IGSF8.

UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
receptor seems to occur (By similarity)

Gene Wiki entry for PTGFRN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGFRN gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   GATA-1   RORalpha1   S8   E2F   E2F-1   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGFRN promoter sequence
   Search Chromatin IP Primers for PTGFRN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGFRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

PTGFRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGFRN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117452:  view genomic region     (about GC identifiers)

Start:
117,452,679 bp from pter      End:
117,532,980 bp from pter
Size:
80,302 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2 (See protein sequence)
Recommended Name: Prostaglandin F2 receptor negative regulator precursor  
Size: 879 amino acids; 98556 Da
Subunit: Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151
Sequence caution: Sequence=BAA92674.1; Type=Erroneous initiation; Sequence=BAC11104.1; Type=Erroneous termination;
Positions=864; Note=Translated as Gln;
Secondary accessions: Q5VVU9 Q8N2K6

Explore the universe of human proteins at neXtProt for PTGFRN: NX_Q9P2B2

Explore proteomics data for PTGFRN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn44, Ser150, Asn286, Asn300, Asn383, Asn413, Asn525, Asn600, Asn618, Asn691
  • Modification sites at PhosphoSitePlus

  • See PTGFRN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065173.2  
    ENSEMBL proteins: 
     ENSP00000376899  

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    antibodies-online proteins for PTGFRN 

     
    antibodies-online peptides for PTGFRN

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    antibodies-online antibodies for PTGFRN (16 products) 

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    antibodies-online kits for PTGFRN (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9P2B2

    ProtoNet protein and cluster: Q9P2B2

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with PTGFRN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPRP_HUMAN, Q9P2B2
    Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
    the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
    receptor seems to occur (By similarity)

         Genatlas biochemistry entry for PTGFRN:
    prostaglandin F2 alpha receptor (FP),negative receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278880
         
    Find genes that share ontologies with PTGFRN           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ptgfrn):
     behavior/neurological 

    Find genes that share phenotypes with PTGFRN           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PTGFRN

    miRNA
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    miRTarBase miRNAs that target PTGFRN:
    hsa-let-7b-5p (MIRT051989), hsa-mir-92a-3p (MIRT049140), hsa-mir-24-3p (MIRT030461), hsa-mir-18a-3p (MIRT040958), hsa-mir-615-3p (MIRT040204), hsa-mir-877-5p (MIRT037210), hsa-mir-30a-5p (MIRT005149)

    Block miRNA regulation of human, mouse, rat PTGFRN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidPTGFRN 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FPRP_HUMAN, Q9P2B2: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Golgi
    apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    plasma membrane3
    extracellular2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PTGFRN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTGFRN
    Interactions:

        GeneGlobe Interaction Network for PTGFRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PTGFRN (Q9P2B22, 3 ENSP000003768994) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD81P600332, 3, ENSP000002636454MINT-8407185 I2D: score=2 STRING: ENSP00000263645
    CD9P219262, 3, ENSP000000091804MINT-8407185 I2D: score=2 STRING: ENSP00000009180
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=2 STRING: ENSP00000257857
    CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
    CD82P277013, ENSP000002271554I2D: score=2 STRING: ENSP00000227155
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034389lipid particle organization IEA--

    Find genes that share ontologies with PTGFRN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTGFRN (FPRP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTGFRN gene: 
    NM_020440.2  

    Unigene Cluster for PTGFRN:

    Prostaglandin F2 receptor inhibitor
    Hs.418093  [show with all ESTs]
    Unigene Representative Sequence: BC152454
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393203(uc001egv.1) ENST00000496699 ENST00000497385
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidPTGFRN 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PTGFRN
      QuantiFast Probe-based Assays in human, mouse, rat PTGFRN

    Additional mRNA sequence: 

    AB014734.1 AB037857.1 AK001863.1 AK024785.1 AK074637.1 BC022235.1 BC042164.1 BC098142.1 
    BC114520.1 BC139718.1 BC152454.1 

    13 DOTS entries:

    DT.117499  DT.95085973  DT.100786281  DT.95153899  DT.100786280  DT.121432910  DT.121632648  DT.100786278 
    DT.121432942  DT.121608331  DT.91737304  DT.91756882  DT.91756884 

    Selected AceView cDNA sequences (see all 517):

    BC063317 AA931766 W58002 W56614 CD679141 BE857712 CA314891 W57857 
    AI656398 AW808040 AA569727 AI262297 AI090820 AA036803 AI367905 AB014734 
    NM_020440 AW627596 AA433926 AI365353 AA826257 AW808004 AI417101 AW808052 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTGFRN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTCAC
    PTGFRN Expression
    About this image


    PTGFRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Stomach (Gastrointestinal Tract)
    PTGFRN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTGFRN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.418093
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTGFRN gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgfrn1 , 5 prostaglandin F2 receptor negative regulator1, 5 86.35(n)1
    89.99(a)1
      3 (43.93 cM)5
    192211  NM_011197.31  NP_035327.21 
     1010402325 
    chicken
    (Gallus gallus)
    Aves PTGFRN1 prostaglandin F2 receptor negative regulator 66.74(n)
    64.77(a)
      418449  XM_416660.4  XP_416660.4 
    lizard
    (Anolis carolinensis)
    Reptilia PTGFRN6
    prostaglandin F2 receptor inhibitor
    62(a)
    1 ↔ 1
    3(162969244-163051159)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004932521 prostaglandin F2 receptor negative regulator-like 53.7(n)
    43.46(a)
      100493252  XM_002943835.2  XP_002943881.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-132g1.71 si:ch211-132g1.7 48.39(n)
    35.91(a)
      101884699  XM_005168313.1  XP_005168370.1 


    ENSEMBL Gene Tree for PTGFRN (if available)
    TreeFam Gene Tree for PTGFRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTGFRN gene
    IGSF82  IGSF32  CD1012  
    1 SIMAP similar gene for PTGFRN using alignment to 4 protein entries:     FPRP_HUMAN (see all proteins):
    smap-6

    Find genes that share paralogs with PTGFRN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTGFRN (see all 1586)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478994901,2
    --115309318(+) TAGTGA/TATACA 1 -- us2k10--------
    rs1818678531,2
    --115309378(+) TAAGCA/GTTCTG 1 -- us2k10--------
    rs1405140131,2
    --115309382(+) CGTTCA/TGGGTG 1 -- us2k10--------
    rs1868682141,2
    --117450704(+) CCTGCA/GAGATT 1 -- us2k10--------
    rs1913595111,2
    --117450857(+) AAATTC/TTTTTT 1 -- us2k10--------
    rs2008932111,2
    --117450930(+) AAAAA-/GAAAGA 1 -- us2k10--------
    rs1504350901,2
    --117450951(+) AGAAGA/GAAAAG 1 -- us2k10--------
    rs24787651,2
    C--117451033(+) AGGAGC/TTCGAG 1 -- us2k18Minor allele frequency- T:0.31WA NA CSA EA 365
    rs1832297751,2
    --117451321(+) CCCCCA/GCCTCC 1 -- us2k10--------
    rs1853437271,2
    --117451330(+) CCCCCG/TGCCCC 1 -- us2k10--------
    rs1156284021,2
    F--117451334(+) CTGCCC/TCCCCA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs120337791,2
    C,F,H--117451498(+) AATCAC/TACATT 1 -- us2k124Minor allele frequency- T:0.16NS EA NA CSA WA 2560
    rs1381235081,2
    --117451607(+) TCTGCA/GATCCG 1 -- us2k10--------
    rs1491390671,2
    --117451923(+) GTGCTA/GTTCTA 1 -- us2k10--------
    rs795040011,2
    F--117452276(+) TGGAAC/GGCGGG 1 -- us2k12Minor allele frequency- G:0.10CSA WA 120
    rs1896572021,2
    --117452300(+) GGGCTA/GAAGCG 1 -- us2k10--------
    rs797698161,2
    C,F--117452322(+) AGACGA/GGTCTT 1 -- us2k12Minor allele frequency- G:0.18NA 122
    rs759080241,2
    C--117452377(+) TGGGGA/GCCCAG 1 -- us2k10--------
    rs1421262551,2
    --117452415(+) CTCCTC/TGCCTT 1 -- us2k10--------
    rs772925831,2
    C--117452869(+) CCTGTC/GGTTGG 2 S W mis12Minor allele frequency- G:0.07WA 120
    rs1481455621,2
    --117453260(+) GGCTCC/GAGAGC 1 -- int10--------
    rs749250231,2
    F--117453290(+) ATGCCC/TCGCCA 1 -- int12Minor allele frequency- T:0.10CSA WA 119
    rs109231631,2
    C,F,A,H--117453533(+) CCTAAA/GAGCCT 1 -- int113Minor allele frequency- G:0.20NS EA WA NA CSA 785
    rs1834641431,2
    --117453628(+) TGAGGC/TTTTGG 1 -- int10--------
    rs1877511051,2
    --117453655(+) CACCCA/GAGGAA 1 -- int10--------
    rs726991111,2
    --117453671(+) TGTGGG/TTTTTT 1 -- int10--------
    rs1411835361,2
    --117453685(+) CTCTCC/TATTTT 1 -- int10--------
    rs730127061,2
    C,F--117453702(+) ACTCCA/GTACAC 1 -- int12Minor allele frequency- G:0.07WA 120
    rs109231641,2
    C,F,H--117453755(+) CCACGG/AAAATA 1 -- int118Minor allele frequency- A:0.09NS EA NA WA 2338
    rs109231651,2
    C,F--117453787(+) GGTACC/GCCAGG 1 -- int19Minor allele frequency- G:0.18WA NA CSA EA 367
    rs1932377061,2
    C--117453890(+) CCAAGC/TCCCTA 1 -- int10--------
    rs24911161,2
    C,F,H--117453943(-) GGCACG/AGACAC 1 -- int15Minor allele frequency- A:0.13NS NA WA 238
    rs1836277671,2
    --117453995(+) ACTTAC/TGGTCA 1 -- int10--------
    rs607176041,2
    F--117454024(+) CTTCTA/GTAGCT 1 -- int11Minor allele frequency- G:0.09WA 118
    rs571321671,2
    C,F--117454025(+) TTCTAT/CAGCTA 1 -- int17Minor allele frequency- C:0.19WA NA CSA EA 364
    rs741117891,2
    C,F--117454029(+) ATAGCT/CACTCC 1 -- int18Minor allele frequency- C:0.16WA NA CSA EA 366
    rs1886248731,2
    --117454124(+) TCTTCC/TTTCAC 1 -- int10--------
    rs1507483541,2
    --117454164(+) CAGAGA/GGCTCG 1 -- int10--------
    rs566771321,2
    C,F--117454308(+) CACCCA/GGTCTG 1 -- int12Minor allele frequency- G:0.08WA 120
    rs569585871,2
    C,F--117454339(+) AGCTCA/CCTGAA 1 -- int12Minor allele frequency- C:0.07WA 120
    rs1148723161,2
    C,F--117454425(+) ACACCC/TGGTGG 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1927298841,2
    --117454450(+) TTTACA/TTTTCA 1 -- int10--------
    rs1847013991,2
    --117454462(+) TCTGGA/GACCCT 1 -- int10--------
    rs595527241,2
    C,F--117454488(+) AGTGGC/TGCACT 1 -- int18Minor allele frequency- T:0.17WA NA CSA EA 365
    rs1389913831,2
    --117454566(+) TGCACA/CGATGG 1 -- int10--------
    rs576012811,2
    C,F--117454570(+) CAGATG/TGTGCA 1 -- int17Minor allele frequency- T:0.24WA NA CSA EA 245
    rs769777041,2
    F--117454812(+) TACTCC/TAGCAT 1 -- int11Minor allele frequency- T:0.01NA 120
    rs24911151,2
    C,H--117454823(-) CAGGAC/AAGGAT 1 -- int112Minor allele frequency- A:0.00NA WA CSA 139
    rs1450784631,2
    C--117454918(+) TGATGA/GCCCTC 1 -- int10--------
    rs1472170151,2
    --117454983(+) GGGAAG/TGTCTC 1 -- int10--------
    rs1406462831,2
    C--117454988(+) GGTCTC/TGCTGT 1 -- int10--------
    rs1882482141,2
    --117454989(+) GTCTCA/GCTGTG 1 -- int10--------
    rs730127121,2
    C,F--117455053(+) AGATCA/C/GTCTTT 1 -- int12WA 120
    rs1443878251,2
    --117455094(+) GGTATC/TGCTGC 1 -- int10--------
    rs766741231,2
    C,F--117455121(+) ATTCAC/TGTAGT 1 -- int11Minor allele frequency- T:0.04NA 120
    rs1911531491,2
    C--117455148(+) CTCCCC/GGTACC 1 -- int10--------
    rs115763171,2
    C,H--117455247(+) CCTGGG/TTGATT 1 -- int10--------
    rs1835832261,2
    --117455488(+) CCTGCC/GTATTA 1 -- int10--------
    rs587550651,2
    C,F--117455549(+) CCTACC/TTACCA 1 -- int15Minor allele frequency- T:0.15WA CSA 126
    rs73664341,2
    C,F,A,H--117455553(+) CCTACC/TATGAT 1 -- int111Minor allele frequency- T:0.12NS EA NA CSA WA 781
    rs1894459201,2
    --117455663(+) CCACTC/GTGTGT 1 -- int10--------
    rs1823730901,2
    --117455665(+) ACTCTA/GTGTGC 1 -- int10--------
    rs776215791,2
    C,F--117455836(+) GATTAA/CTTTTG 1 -- int12Minor allele frequency- C:0.02NA 122
    rs1869313871,2
    --117455860(+) GGCTGG/TTTTTG 1 -- int10--------
    rs1130800011,2
    C--117456001(+) TGGCAC/TGTAAG 1 -- int10--------
    rs1812825861,2
    --117456035(+) GAGGAA/GGAAAT 1 -- int10--------
    rs1488810351,2
    --117456312(+) AATAGA/GATATA 1 -- int10--------
    rs1855887181,2
    C--117456400(+) CCATTA/GAAAGT 1 -- int10--------
    rs22543711,2
    C,F--117456427(+) ACAGGA/GCAGGG 1 -- int14Minor allele frequency- G:0.25NA WA 124
    rs22543701,2
    C,F--117456444(+) GTTGAG/CGAGGA 1 -- int12Minor allele frequency- C:0.25WA 120
    rs1899066431,2
    --117456466(+) CTAGTA/GCAACA 1 -- int10--------
    rs1428459131,2
    --117456506(+) GTAGGA/GTGGGA 1 -- int10--------
    rs1510755741,2
    --117456543(+) TTTTGC/TAAATC 1 -- int10--------
    rs1824184321,2
    --117456593(+) GTATTG/TTAAAA 1 -- int10--------
    rs559280271,2
    C--117456625(+) TTGTAT/GTAATC 1 -- int12Minor allele frequency- G:0.03WA 120
    rs1852266141,2
    --117456639(+) TAGGCC/TAAACT 1 -- int10--------
    rs1920999021,2
    --117456698(+) TATAAA/CAATGC 1 -- int10--------
    rs768340121,2
    C,F--117456839(+) CCATTC/TCAGCC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs22543481,2
    C,F,H--117456936(+) GTTCTA/GTTGGA 1 -- int114Minor allele frequency- G:0.14NS EA NA WA 1664
    rs1142676831,2
    F--117456953(+) TTGGGC/ACCATG 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1409301821,2
    --117457004(+) CTACTA/GTGGAA 1 -- int10--------
    rs1450189391,2
    --117457015(+) GAAGGC/GAAAGA 1 -- int10--------
    rs1838978881,2
    --117457127(+) CAGCAC/GTTTGG 1 -- int10--------
    rs1883939641,2
    --117457162(+) GAGATA/CAGGAG 1 -- int10--------
    rs1930568161,2
    --117457177(+) AGACCA/GGCCTG 1 -- int10--------
    rs1478880061,2
    C--117457416(+) TGCCC-/AGGCA 
            
    CAGCC
    1 -- int10--------
    rs1825895911,2
    --117457421(+) AGGCAC/TAGCCA 1 -- int10--------
    rs1149699611,2
    F--117457444(+) GTGTGT/AGTGTC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1402282211,2
    C--117457479(+) TTTTT-/CCTCAT 1 -- int10--------
    rs773963591,2
    C--117457651(+) ACTGAG/TGCCCA 1 -- int10--------
    rs1871546081,2
    --117457737(+) CTGTCA/TCTGCT 1 -- int10--------
    rs1407011651,2
    --117457782(+) GCTGCG/TTATTG 1 -- int10--------
    rs1459021271,2
    C--117457786(+) CGTATG/TGCTTG 1 -- int10--------
    rs22542241,2
    C,F,A,H--117457864(+) CCAGGG/ATTAGT 1 -- int126Minor allele frequency- A:0.29NS EA NA WA CSA 2772
    rs747217251,2
    F--117458138(+) GCCAAG/CCTGAT 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1916021061,2
    --117458189(+) GAATAA/GGAACT 1 -- int10--------
    rs1410873381,2
    C--117458252(+) GGCTG-/GTT   
       TTTTT
    TTTTG
    1 -- int10--------
    rs1837727771,2
    --117458286(+) GATTTC/TCCCCC 1 -- int10--------
    rs22541211,2
    C,F,A,H--117458375(+) TCTGCG/ATCTCA 1 -- int123Minor allele frequency- A:0.30NS EA NA WA CSA 2349
    rs747450091,2
    F--117458484(+) GACTCT/AGCTTT 1 -- int12Minor allele frequency- A:0.10CSA WA 120
    rs1866151931,2
    --117458559(+) CAGTTG/TGCACA 1 -- int10--------
    rs1382482621,2
    --117458634(+) AGAATC/TAGACC 1 -- int10--------
    rs590784691,2
    C,F--117458730(+) AAGGCT/CGATTT 1 -- int14Minor allele frequency- C:0.26WA CSA 123
    rs2005889571,2
    --117458761(+) GTCAC-/GGTAAGC 1 -- int10--------
    rs754067501,2
    F--117458806(+) CCTTAA/GTTGCA 1 -- int12Minor allele frequency- G:0.10CSA WA 120
    rs1931050641,2
    --117458837(+) AGCAGC/TTGGAA 1 -- int10--------
    rs1160043271,2
    F--117459175(+) GGTGGG/TTTGTC 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1855089301,2
    C--117459232(+) CCTGCA/GTACCC 1 -- int10--------
    rs1900806371,2
    --117459288(+) GACGAA/GGGATG 1 -- int10--------
    rs1496161681,2
    --117459388(+) ACACGG/TCTAGC 1 -- int10--------
    rs1816643341,2
    --117459441(+) CACGCC/TGGGCA 1 -- int10--------
    rs1434978461,2
    --117459599(+) TGAAAA/GGGAGA 1 -- int10--------
    rs22539731,2
    C,F,A,H--117459835(+) AACTCT/CGAGTC 1 -- int118Minor allele frequency- C:0.22NS EA NA WA CSA 2222
    rs1844760071,2
    --117459850(+) ACGATC/TGCCCA 1 -- int10--------
    rs105937331,2
    C--117459932(+) CTTAA-/ACAGGAT 1 -- int11Minor allele frequency- AC:0.50CSA 2
    rs105543971,2
    C--117459933(+) TTAAA-/CAGGATC 1 -- int10--------
    rs1887876191,2
    --117459960(+) AGGCCC/GACAGG 1 -- int10--------
    rs1812294861,2
    --117460162(+) AGTCTC/TTGCAG 1 -- int10--------
    rs109231661,2
    C,F,A,H--117460284(+) TCTCAC/GGCTAT 1 -- int16Minor allele frequency- G:0.30NA EA 248
    rs1853479741,2
    --117460286(+) TCACGC/TTATCA 1 -- int10--------
    rs75267141,2
    C,F--117460454(+) ttctcG/Agactg 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1908447721,2
    --117460478(+) GGCCTC/TAAGTG 1 -- int10--------
    rs1480189281,2
    --117460513(+) ATATCA/GTTAGC 1 -- int10--------
    rs730127201,2
    C,F--117460524(+) CACTGC/TGCCCG 1 -- int14Minor allele frequency- T:0.16WA CSA 123
    rs1434048661,2
    --117460583(+) TGTCCC/TTCTGG 1 -- int10--------
    rs1822050891,2
    --117460629(+) ACTCTC/GTGATA 1 -- int10--------
    rs22510921,2
    C,F--117460743(+) TTTGTA/GTTACA 1 -- int14Minor allele frequency- G:0.25NA WA 124
    rs1872378351,2
    --117460787(+) CTTCTC/GTTCTT 1 -- int10--------
    rs763492271,2
    C,F--117460900(+) GAACCT/CTGGAC 1 -- int11Minor allele frequency- C:0.06WA 118
    rs73650571,2
    C,F,A,H--117460934(+) TCACTT/CTCTGT 1 -- int130Minor allele frequency- C:0.08NS EA NA WA 3328
    rs1403203861,2
    --117461098(+) GGGGAA/GTCTCA 1 -- int10--------
    rs1136464491,2
    C--117461190(+) TCTGGA/GGGAGG 1 -- int12Minor allele frequency- G:0.10CSA WA 120
    rs1428572221,2
    --117461219(+) TGGTAG/TTCTGG 1 -- int10--------
    rs1508007151,2
    --117461272(+) AGCTGA/GAGGAG 1 -- int10--------
    rs730127221,2
    C,F--117461275(+) TGGAGG/AAGAGT 1 -- int14Minor allele frequency- A:0.08WA CSA 124
    rs1391453821,2
    --117461300(+) CCCCAC/TGGGAA 1 -- int10--------
    rs1919064171,2
    --117461342(+) GGAGGA/CTAGCA 1 -- int10--------
    rs1829731851,2
    --117461475(+) GGAACC/TGAGGG 1 -- int10--------
    rs1499418361,2
    C--117461563(+) GATGCA/GCCTGC 1 -- int10--------
    rs1452386081,2
    --117461568(+) ACCTGC/GAGAAG 1 -- int10--------
    rs22509651,2
    C,F,O,H--117461600(+) GATGAT/CGGCAT 1 -- int120Minor allele frequency- C:0.11NA NS EA WA 1960
    rs1487510221,2
    --117461703(+) AGCAGA/CGATCT 1 -- int10--------
    rs1873478921,2
    --117461719(+) GAGATA/GGGCTG 1 -- int10--------
    rs603241641,2
    C,F--117461913(+) GTTGGG/AGACCA 1 -- int14Minor allele frequency- A:0.13WA CSA 124
    rs1998216561,2
    --117462030(+) TTTTC-/TTTTTT 1 -- int10--------
    rs558619491,2
    C--117462039(+) TTTTTT/AAAGAG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs22509511,2
    C,F--117462050(-) AGAGAC/ACCCCT 1 -- int1 trp36Minor allele frequency- A:0.24WA NA CSA EA 364
    rs1467757601,2
    --117462106(+) CCTCAA/GCCTCC 1 -- int10--------
    rs22508841,2
    C,F,A--117462113(+) CTCCCT/AGGCTG 1 -- int18Minor allele frequency- A:0.23NA CSA WA EA 367
    rs22508831,2
    C,F,A--117462118(+) TGGCTG/CAAGTG 1 -- int16Minor allele frequency- C:0.23NA CSA WA EA 363
    rs22508821,2
    C,F,A,H--117462152(-) GTTCCG/AGCTGC 1 -- int112Minor allele frequency- A:0.11NS EA NA WA CSA 766
    rs1151605691,2
    C,F--117462478(+) AGGCTT/GGGATT 1 -- int11Minor allele frequency- G:0.06WA 118
    rs1167287271,2
    F--117462634(+) CTGCTG/ATTGGC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs730127251,2
    C,F--117462648(+) GTGGCC/GTCTTG 1 -- int15Minor allele frequency- G:0.13WA CSA 125
    rs22508651,2
    C,F,O,A,H--117462691(-) TATAAG/AGAGTG 1 -- int124Minor allele frequency- A:0.21NS EA NA WA CSA 2302
    rs1902771891,2
    --117462786(+) TGTTCA/GGTCCT 1 -- int10--------
    rs22508551,2
    C,F,O,A,H--117462800(-) CAGTCG/ACCTAC 1 -- int115Minor allele frequency- A:0.22NS EA NA WA CSA 926
    rs22508491,2
    C,F,A,H--117462941(+) AAAACT/CAATAA 1 -- int112Minor allele frequency- C:0.22NS EA WA NA CSA 776
    rs22507451,2
    C,F,A,H--117463140(-) ATACTG/AGGAAA 1 -- int1 trp312Minor allele frequency- A:0.19NS EA NA WA CSA 786
    rs1823997111,2
    --117463141(+) TTCCCA/GGTATG 1 -- int10--------
    rs22507441,2
    C,F,O,A--117463154(-) CTGTGG/TTCTGG 1 -- int112Minor allele frequency- T:0.23NA WA CSA EA 506
    rs22507371,2
    C,F,O,A--117463218(+) CTTTTA/GCACCC 1 -- int111Minor allele frequency- G:0.22NA WA CSA EA 508
    rs1405167041,2
    C--117463328(+) GCAACC/TACTGC 1 -- int10--------
    rs22507291,2
    C,F,A--117463353(-) CATGAG/TAATTG 1 -- int18Minor allele frequency- T:0.10NA WA CSA EA 251
    rs1876104461,2
    --117463497(+) TGCCTC/TAGCCT 1 -- int10--------
    rs21826041,2
    C,F,A--117463516(+) GCTGGG/AATTAC 1 -- int13Minor allele frequency- A:0.29NA 124
    rs21826051,2
    C,F,A,H--117463537(+) TACCAT/CGTCTA 1 -- int122Minor allele frequency- C:0.50NS EA NA WA CSA 2348
    rs22507151,2
    C,F,O,A,H--117463715(+) GTCTAT/CGTGTT 1 -- int123Minor allele frequency- C:0.30NS EA NA WA CSA 2347
    rs1926265811,2
    C--117463850(+) GTTTTA/GGATGC 1 -- int10--------
    rs1856205201,2
    --117463857(+) ATGCAA/GATATT 1 -- int10--------
    rs1891969451,2
    --117463882(+) CTTTAA/GGATGT 1 -- int10--------
    rs28068611,2
    C,F,O,A,H--117463895(+) TGAGAA/GGCGAA 1 -- int114Minor allele frequency- G:0.17EA NA NS WA CSA 878
    rs751936821,2
    F--117463897(+) AGAAGC/TGAATA 1 -- int12Minor allele frequency- T:0.12CSA WA 120
    rs1924510421,2
    --117463994(+) TATTCA/GTTTTC 1 -- int10--------
    rs1847143801,2
    --117463999(+) GTTTTC/TCCATT 1 -- int10--------
    rs1889096701,2
    --117464063(+) TCCATC/GATCTT 1 -- int10--------
    rs170365251,2
    C,F--117464419(+) TCACTG/ATACAT 1 -- int15Minor allele frequency- A:0.05NA CSA WA 262
    rs1157302271,2
    C,F--117464462(+) AGGCCA/GGGGGC 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1812857371,2
    --117464537(+) AAATGC/TATTTC 1 -- int10--------
    rs1511298171,2
    --117464728(+) GAAAGA/GTGTTG 1 -- int10--------
    rs1118698631,2
    F--117464747(+) ACCAGC/TGCCCA 1 -- int12Minor allele frequency- T:0.02CSA WA 120
    rs1164147791,2
    F--117464769(+) AGAGCC/TGGCAT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1410400221,2
    --117464913(+) CCCCCA/GGATAG 1 -- int10--------
    rs1502546341,2
    --117465158(+) GGTACC/TTTTGT 1 -- int10--------
    rs1156800611,2
    C,F--117465200(+) AAGGTG/AGCATA 1 -- int11Minor allele frequency- A:0.05WA 118
    rs170365281,2
    C,F,H--117465252(+) CGAGTT/CAGCTC 1 -- int112Minor allele frequency- C:0.05NA NS EA WA CSA 675
    rs341711471,2
    C,F--117465331(+) ATGAGG/ACAAGC 1 -- int14Minor allele frequency- A:0.04NA WA 124
    rs1379713571,2
    C--117465543(+) GTTATC/TTGATT 1 -- int10--------
    rs1434949431,2
    --117465548(+) TTGATG/TCTTTG 1 -- int10--------
    rs1458885841,2
    --117465719(+) TATTAC/GGATGA 1 -- int10--------
    rs1840484571,2
    --117465747(+) CCAACC/TGTAAG 1 -- int10--------
    rs22504571,2
    C,F,O,A,H--117465765(+) AAAGCA/GGGATC 1 -- int128Minor allele frequency- G:0.25NA NS EA WA CSA 2796
    rs1386125041,2
    --117465792(+) ACCCCA/CGCATG 1 -- int10--------
    rs1892277391,2
    --117465806(+) GAACTA/TGAATC 1 -- int10--------
    rs1427230041,2
    --117465822(+) ATAATC/TGAATT 1 -- int10--------
    rs22504481,2
    C,F,A--117465862(-) ATATAC/TACACC 1 -- int17Minor allele frequency- T:0.23NA WA CSA EA 366
    rs1810243331,2
    --117465864(+) TGTGTA/GTATTA 1 -- int10--------
    rs1858578951,2
    C--117465885(+) AAATTA/GTGGAC 1 -- int10--------
    rs781110941,2
    C,F--117465903(+) TATAAC/TAGGGG 1 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs22504451,2
    C,F,A,H--117465904(+) ATAACA/GGGGGC 1 -- int120Minor allele frequency- G:0.30NS EA WA NA CSA 2342
    rs1445985101,2
    --117465922(+) ATCTAA/TGTGTC 1 -- int10--------
    rs765933171,2
    C,F--117465937(+) TTACTA/GTCTTT 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1484904501,2
    --117466012(+) AGGTTA/TTTGTG 1 -- int10--------
    rs22504391,2
    C,F,A,H--117466050(-) TCTTTA/TACATG 1 -- int18Minor allele frequency- T:0.20EA NS WA NA CSA 528
    rs1417231811,2
    C--117466089(+) CCTGTA/GGATTT 1 -- int10--------
    rs1505543031,2
    C--117466106(+) TTTTTC/TCCTTG 1 -- int10--------
    rs755574271,2
    C,F--117466153(+) CATTAT/CTGTTT 1 -- int11Minor allele frequency- C:0.06WA 118
    rs1924875231,2
    --117466155(+) TTATTA/GTTTCT 1 -- int10--------
    rs170365401,2
    C,F--117466202(+) CAACCG/ATTTCC 1 -- int18Minor allele frequency- A:0.04NA WA CSA 268
    rs22503371,2
    C,F,O,A,H--117466243(+) GCTTCG/ATCCTG 1 -- int129Minor allele frequency- A:0.24NA NS EA WA CSA 2912
    rs1399265761,2
    --117466340(+) CATCTA/GCTTGT 1 -- int10--------
    rs769079951,2
    C,F--117466418(+) TGTAGC/TGTGGG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs764771751,2
    C--117466533(+) TGACTC/TCTCCA 1 -- int10--------
    rs1436481181,2
    --117466552(+) TCTAAA/GTGTGG 1 -- int10--------
    rs1468155941,2
    --117466557(+) ATGTGC/GAGGAT 1 -- int10--------
    rs726991131,2
    --117466567(+) TGACAC/GACACA 1 -- int10--------
    rs22503231,2
    C,F,A--117466806(+) ACTCTG/TTTGCC 1 -- int13Minor allele frequency- T:0.33WA NA CSA 6
    rs1818554181,2
    --117466855(+) ACCTCC/TGCCTC 1 -- int10--------
    rs2000632391,2
    --117466925(+) CACCA-/CACC  
            
    CGGCT
    1 -- int10--------
    rs633887611,2
    C--117466926(+) ACCACACCCG/
            
    GCTAA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs73660041,2
    C--117466930(+) CACCCC/GGCTAA 1 -- int10--------
    rs3703849341,2
    C--117467009(+) GATCT-/AACCTG 1 -- int10--------
    rs1859128081,2
    --117467084(+) TAAAGA/GCATTA 1 -- int10--------
    rs1903236921,2
    --117467114(+) GACTTC/TTGTAA 1 -- int10--------
    rs28068621,2
    C,F,O,A,H--117467173(+) TGTAAG/ATAAAA 1 -- int130Minor allele frequency- A:0.29NS EA NA WA CSA 2915
    rs763183161,2
    F--117467246(+) ACTGGT/CCCCTT 1 -- int11Minor allele frequency- C:0.01EA 120
    rs1826144751,2
    C--117467258(+) ATTGAC/TGCTGT 1 -- int10--------
    rs1881324971,2
    --117467317(+) TGGTGA/GAGGGC 1 -- int10--------
    rs1911210251,2
    --117467326(+) GCTATG/TTTTGA 1 -- int10--------
    rs781689441,2
    F--117467401(+) GATGAC/TGATCC 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1454006361,2
    --117467633(+) GGGAAC/GGATCA 1 -- int10--------
    rs9433711,2
    C,F,O,A,H--117467690(+) ATGATG/CAGTAG 1 -- int129Minor allele frequency- C:0.23NA NS EA WA CSA 2914
    rs1829640861,2
    --117467691(+) TGATGA/TGTAGG 1 -- int10--------
    rs1875866731,2
    --117467776(+) CTGTCC/GCAGTG 1 -- int10--------
    rs2012716761,2
    C--117467779(+) TCGCA-/GTGGCT 1 -- int10--------
    rs7534511,2
    C,F,A--117467834(+) CGCTTG/TAGGCC 1 -- int18Minor allele frequency- T:0.33NA WA CSA EA 249
    rs120727261,2
    --117468057(+) AAAAAA/GAAAAA 1 -- int1 trp30--------
    rs1127650951,2
    C--117468057(+) AAAAA-/AGATAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1925489011,2
    --117468342(+) TCTTAC/TTGGGG 1 -- int10--------
    rs1492266381,2
    --117468552(+) AGAGTC/GTTTTT 1 -- int10--------
    rs7559971,2
    C,F,O,H--117468576(-) TTTGGC/TTTGCA 1 -- int122Minor allele frequency- T:0.03NS EA NA WA CSA 2018
    rs1139097741,2
    F--117468607(+) CCTTAC/TTGAGC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1118224151,2
    F--117468617(+) CCTCAT/ACAGGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1832165891,2
    --117468628(+) AAGCTC/TGGCAT 1 -- int10--------
    rs672874911,2
    C--117468687(+) GGCAG-/GCTTAA 1 -- int10--------
    rs2013796531,2
    --117468696(+) TAAAG-/TGTTGTTG 1 -- int10--------
    rs671804961,2
    C--117468698(+) TGTTG-/TTGGGGAG 1 -- int10--------
    rs120329841,2
    C,F--117468752(+) CTAGGG/TAACAG 1 -- int15Minor allele frequency- T:0.09NA CSA WA EA 362
    rs1417622571,2
    --117468767(+) ATAACA/GGGAGA 1 -- int10--------
    rs7559961,2
    C,F,O,H--117468906(-) GTCCTC/GTTTTT 1 -- int1 trp310Minor allele frequency- G:0.02NS EA NA WA CSA 560
    rs170365641,2
    C,F,H--117468908(+) AAAGAG/CGACCA 1 -- int1 trp38Minor allele frequency- C:0.03NA NS EA CSA WA 562
    rs1458237431,2
    --117468957(+) TTGAAC/TGTGGA 1 -- int10--------
    rs1875894421,2
    --117468958(+) TGAACA/GTGGAG 1 -- int10--------
    rs22500961,2
    C,F,A,H--117468983(-) TCCCTG/ACTCAG 1 -- int121Minor allele frequency- A:0.25NS EA NA WA CSA 2346
    rs1162744521,2
    F--117469198(+) ATTATC/TGCTTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs774855411,2
    F--117469308(+) TGCATG/ATAAGG 1 -- int11Minor allele frequency- A:0.03EA 120
    rs22499841,2
    C,F,O--117469322(-) GCAAAA/TAAAAG 1 -- int1 trp310Minor allele frequency- T:0.23NA WA CSA EA 502
    rs1387651341,2
    --117469362(+) CTACTC/GAATAC 1 -- int10--------
    rs27673411,2
    C,F,H--117469401(+) ggaagC/Gagaac 1 -- int18Minor allele frequency- G:0.15NS EA NA WA 542
    rs28068631,2
    C,F,A,H--117469513(+) TATCAA/GGGAAA 1 -- int126Minor allele frequency- G:0.24NS EA NA WA CSA 2772
    rs27673421,2
    C,F,A,H--117469637(+) TTAGCC/TCCGAG 1 -- int113Minor allele frequency- T:0.28NS EA WA NA CSA 785
    rs1160816491,2
    C,F--117469735(+) ACAAAC/TGGGTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs28068641,2
    C,F,A,H--117469781(+) TTAACC/GACGAG 1 -- int125Minor allele frequency- G:0.24NS EA NA WA CSA 2768
    rs1920142841,2
    --117469876(+) ACTACA/GCAGAT 1 -- int10--------
    rs75288811,2
    C,F,H--117470023(+) TAGTTA/GTATGA 1 -- int16Minor allele frequency- G:0.05NS EA CSA WA 538
    rs1181493881,2
    F--117470091(+) GTACCG/ATGCAT 1 -- int11Minor allele frequency- A:0.02EA 120
    rs1161130971,2
    --117470116(+) TGTTGA/GTGGCA 1 -- int10--------
    rs120721611,2
    --117470165(+) tttttC/Ttgata 1 -- int1 trp30--------
    rs1851019851,2
    --117470223(+) CAATCA/GTGACT 1 -- int10--------
    rs22471451,2
    C,F,A--117470312(-) TGGGCA/GTGGTG 1 -- int15Minor allele frequency- G:0.09WA NA CSA EA 246
    rs170365731,2
    C,F,H--117470494(+) TTGACT/GTTGAA 1 -- int124Minor allele frequency- G:0.08NA NS EA WA 2906
    rs1411075461,2
    --117470533(+) GTCTTC/TGTCGC 1 -- int10--------
    rs1503044511,2
    --117470610(+) AAATGA/GCAGGA 1 -- int10--------
    rs28068651,2
    C,F,O,H--117470612(+) ATGGCA/TGGATA 1 -- int19Minor allele frequency- T:0.10NA NS EA WA 680
    rs115834221,2
    C,F,H--117470845(+) GCCTTG/CTCATC 1 -- int16Minor allele frequency- C:0.02NS EA NA 536
    rs1150881811,2
    F--117470850(+) GTCATC/AACTTA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1379268501,2
    --117470882(+) TGTCAA/GTTCTG 1 -- int10--------
    rs730127361,2
    C,F--117470888(+) TTCTGA/GTATTT 1 -- int12Minor allele frequency- G:0.04WA 120
    rs1149660031,2
    C,F--117470907(+) GACCAC/TAACCT 1 -- int11Minor allele frequency- T:0.06WA 118
    rs120875331,2
    C,F,H--117470954(+) TGAACC/GTATTC 1 -- int116Minor allele frequency- G:0.13NS EA NA WA CSA 932
    rs1899496281,2
    C--117470958(+) CCTATC/TCTTCA 1 -- int10--------
    rs28068661,2
    C,F,O,A,H--117471094(+) CAACCT/CGGGAC 1 -- int112Minor allele frequency- C:0.18NA NS EA WA CSA 678
    rs1926899431,2
    --117471159(+) CACCAA/GTCGTA 1 -- int10--------
    rs1846334551,2
    --117471252(+) TTTACC/TGCAGC 1 -- int10--------
    rs1495267751,2
    --117471253(+) TTACCA/GCAGCT 1 -- int10--------
    rs1394487941,2
    C--117471264(+) AGCTC-/ATCCTT 1 -- int10--------
    rs1441500671,2
    --117471286(+) TGTGAC/TGGTTT 1 -- int10--------
    rs730127371,2
    C,F--117471427(+) TATTTG/TTACTC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs22470251,2
    C,F,H--117471509(-) CACTTG/AGGGAA 1 -- int1 trp38Minor allele frequency- A:0.20NS EA WA CSA 544
    rs1417939671,2
    --117471750(+) AGTGGC/TATCAC 1 -- int10--------
    rs1880006201,2
    --117471817(+) TCATTC/TCCCAC 1 -- int10--------
    rs1159074981,2
    C,F--117471914(+) AAGGCC/TGGTGT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1463307361,2
    --117471975(+) GCTTCC/TAAATT 1 -- int10--------
    rs1818960431,2
    --117472026(+) AATTTC/GTACAA 1 -- int10--------
    rs120784611,2
    C,F,A,H--117472049(+) ctatcG/Attttc 1 -- int128Minor allele frequency- A:0.13NS EA NA WA CSA 2914
    rs1396449321,2
    C--117472154(+) AACACC/TCAAGC 1 -- int10--------
    rs1861549011,2
    --117472321(+) ACTGAA/GTAGCA 1 -- int10--------
    rs598391911,2
    C,F--117472528(+) TCCTTC/GTCTCC 1 -- int13Minor allele frequency- G:0.07WA CSA 122
    rs1427765751,2
    --117472530(+) CTTCTC/TTCCTG 1 -- int10--------
    rs1890057921,2
    --117472556(+) ATCCCA/GTACCC 1 -- int10--------
    rs1816558791,2
    --117472561(+) ATACCC/TGTCAT 1 -- int10--------
    rs1866707971,2
    --117472575(+) AAATGC/TGCTTT 1 -- int10--------
    rs1506078891,2
    C--117472591(+) AGGTTA/GCCAGT 1 -- int10--------
    rs1397004181,2
    --117472702(+) TATAGG/TAGGAG 1 -- int10--------
    rs28068671,2
    C,F,O,A,H--117472703(+) ATAGTA/GGGAGT 1 -- int125Minor allele frequency- G:0.21NA NS EA WA CSA 2237
    rs22468931,2
    C,F,O,A,H--117472815(+) AAAGAA/GACAGT 1 -- int123Minor allele frequency- G:0.19NA NS EA WA CSA 2466
    rs1498412811,2
    --117472854(+) TTCTTG/TCATCC 1 -- int10--------
    rs22468901,2
    C,F,A,H--117472906(-) TAGTAA/GCCAGT 1 -- int18Minor allele frequency- G:0.19NS EA WA CSA 540
    rs726991141,2
    C,F--117472964(+) ATAGGA/GCTTTG 1 -- int11Minor allele frequency- G:0.01NA 120
    rs21486341,2
    C,F,A,H--117472999(+) TTTCTA/GTACAG 1 -- int127Minor allele frequency- G:0.40NS EA NA WA CSA 2770
    rs1916144351,2
    --117473083(+) CCCTCC/TGTGCA 1 -- int10--------
    rs1829603721,2
    --117473125(+) TCTTCC/TAGGGG 1 -- int10--------
    rs120904101,2
    H--117473178(+) TCTTAC/ATATAA 1 -- int14Minor allele frequency- A:0.00NS EA 400
    rs1144491671,2
    F--117473285(+) GCTGCC/TTTTTG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs730127461,2
    C,F--117473341(+) CATTGA/GTAGAG 1 -- int13Minor allele frequency- G:0.11WA CSA 122
    rs1860984391,2
    --117473366(+) CTCTGA/GGCCTC 1 -- int10--------
    rs170365911,2
    C,F,H--117473419(+) ACCCTG/ATCTTC 1 -- int128Minor allele frequency- A:0.23NA NS EA WA CSA 2902
    rs1452198241,2
    C--117473436(+) ACCTG-/CCTGTG 1 -- int10--------
    rs1897349681,2
    C--117473448(+) CCCCCA/GTGGCC 1 -- int10--------
    rs1479580721,2
    --117473463(+) TAGGTC/GTTTGC 1 -- int10--------
    rs1417402821,2
    --117473576(+) ACTGCA/GTGAAG 1 -- int10--------
    rs115832521,2
    C,F,H--117473588(+) TTTTTA/GTGAAT 1 -- int125Minor allele frequency- G:0.17NS EA NA WA CSA 2532
    rs1455902871,2
    --117473755(+) TGATAC/TGTTGC 1 -- int10--------
    rs19989211,2
    C,H--117473840(+) TGGTAA/GGAATG 1 -- int116Minor allele frequency- G:0.00NS EA NA WA CSA 794
    rs795984241,2
    F--117473966(+) CATACG/ATGCCT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1477920861,2
    --117473968(+) TACGTA/GCCTTA 1 -- int10--------
    rs105974341,2
    C--117474119(+) TTTTC-/T/T   
       T
    /TTT
    TTTTT
    2 -- int1 cds11CSA 2
    rs717367781,2
    C--117474119(+) TTTTC-/TTTTTTTT 1 -- int10--------
    rs24911141,2
    C,F,A,H--117474146(-) ACAGTG/ACTTAT 1 -- int120Minor allele frequency- A:0.20NS EA NA WA CSA 2345
    rs24911131,2
    C,F,A,H--117474163(-) AATAAG/AGTTCT 1 -- int120Minor allele frequency- A:0.20NS EA NA WA CSA 2335
    rs24911121,2
    C,F,O,A,H--117474210(-) GTAATG/AAAGTC 1 -- int113Minor allele frequency- A:0.18NA NS EA WA CSA 901
    rs24787661,2
    C,F,A,H--117474229(+) TGCTGT/GCTATA 1 -- int115Minor allele frequency- G:0.18NA NS EA WA CSA 917
    rs108019151,2
    C,F,A,H--117474397(+) TTTATG/AAGTTT 1 -- int130Minor allele frequency- A:0.31NA NS EA WA CSA 2905
    rs1834433871,2
    --117474415(+) TGTGCA/CTTCAT 1 -- int10--------
    rs1488430261,2
    --117474469(+) AGGCCC/TCGAGT 1 -- int10--------
    rs780691761,2
    C,F--117474471(+) GCCCCG/AAGTCT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs781293221,2
    C,F--117474608(+) TGATAC/ATTATC 1 -- int12Minor allele frequency- A:0.03WA NA 238
    rs1435048761,2
    --117474612(+) ACTTAC/TCTTAC 1 -- int10--------
    rs1475040831,2
    --117474693(+) AAATAA/GAAACA 1 -- int10--------
    rs1407100121,2
    --117474726(+) ATGCTA/GTACTC 1 -- int10--------
    rs1127581821,2
    F--117474807(+) AGGAGG/CTGGAA 1 -- int12Minor allele frequency- C:0.02CSA WA 120
    rs29981831,2
    C,F,A,H--117474876(+) GGTTGG/ACAATA 1 -- int129Minor allele frequency- A:0.19NA NS EA WA CSA 2914
    rs29981841,2
    C,F,O,A,H--117474956(+) CCATCG/AATTCC 1 -- int114Minor allele frequency- A:0.18NA NS EA WA CSA 924
    rs1880228041,2
    --117474966(+) CACCTA/GATAGA 1 -- int10--------
    rs29981851,2
    C,F,O,A--117474980(+) AAGTCG/AAAGGC 1 -- int110Minor allele frequency- A:0.19NA WA CSA EA 496
    rs1501656371,2
    C--117475014(+) CCAGAA/GGTAGG 1 -- int10--------
    rs124044911,2
    H--117475110(+) CCTGTA/GTGATT 1 -- int14Minor allele frequency- G:0.00NS EA 418
    rs24787671,2
    C,F,O,A--117475157(+) ATATGC/TGTGGT 1 -- int19Minor allele frequency- T:0.20NA WA CSA EA 501
    rs73658811,2
    C,F,A,H--117475175(+) TTGGTG/ATCACT 1 -- int115Minor allele frequency- A:0.34NA WA CSA EA 514
    rs1924443641,2
    --117475241(+) AGTTTA/CTTCTA 1 -- int10--------
    rs1421336941,2
    C--117475246(+) TCTATT/-TCTCT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs24911111,2
    C,F,A--117475258(-) GTAGAC/TAGATG 1 -- int19Minor allele frequency- T:0.19NA CSA WA EA 498
    rs29981861,2
    C,F,O,A,H--117475461(+) AATCCG/AACCTA 1 -- int128Minor allele frequency- A:0.19NA NS EA WA CSA 2913
    rs19989221,2
    C,F,O,A,H--117475715(+) ATTCTG/AATATT 1 -- int132Minor allele frequency- A:0.35EA NA NS WA CSA 2986
    rs29981871,2
    C,F,O,A,H--117475792(+) GAGAAG/ATGCTT 1 -- int114Minor allele frequency- A:0.19NA WA CSA EA 507
    rs1387820301,2
    --117475973(+) ACTTCC/TAGGAT 1 -- int1