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Aliases for PTGFRN Gene

Aliases for PTGFRN Gene

  • Prostaglandin F2 Receptor Inhibitor 2 3 5
  • Prostaglandin F2-Alpha Receptor Regulatory Protein 3 4
  • Prostaglandin F2-Alpha Receptor-Associated Protein 3 4
  • Glu-Trp-Ile EWI Motif-Containing Protein F 3 4
  • CD9 Partner 1 3 4
  • CD9P-1 3 4
  • EWI-F 3 4
  • FPRP 3 4
  • Prostaglandin F2 Receptor Negative Regulator 2
  • CD315 Antigen 4
  • KIAA1436 4
  • SMAP-6 3
  • CD315 3
  • CD9P1 4
  • EWIF 4

External Ids for PTGFRN Gene

Previous GeneCards Identifiers for PTGFRN Gene

  • GC01P117943
  • GC01P116322
  • GC01P116600
  • GC01P116796
  • GC01P116799
  • GC01P117164
  • GC01P117254
  • GC01P117452
  • GC01P115311

Summaries for PTGFRN Gene

GeneCards Summary for PTGFRN Gene

PTGFRN (Prostaglandin F2 Receptor Inhibitor) is a Protein Coding gene. An important paralog of this gene is CD101.

UniProtKB/Swiss-Prot for PTGFRN Gene

  • Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).

Gene Wiki entry for PTGFRN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGFRN Gene

Genomics for PTGFRN Gene

Regulatory Elements for PTGFRN Gene

Promoters for PTGFRN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTGFRN on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGFRN Gene

Chromosome:
1
Start:
116,909,923 bp from pter
End:
116,990,358 bp from pter
Size:
80,436 bases
Orientation:
Plus strand

Genomic View for PTGFRN Gene

Genes around PTGFRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGFRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGFRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGFRN Gene

Proteins for PTGFRN Gene

  • Protein details for PTGFRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2B2-FPRP_HUMAN
    Recommended name:
    Prostaglandin F2 receptor negative regulator
    Protein Accession:
    Q9P2B2
    Secondary Accessions:
    • Q5VVU9
    • Q8N2K6

    Protein attributes for PTGFRN Gene

    Size:
    879 amino acids
    Molecular mass:
    98556 Da
    Quaternary structure:
    • Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.
    SequenceCaution:
    • Sequence=BAA92674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11104.1; Type=Erroneous termination; Positions=864; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for PTGFRN Gene

Proteomics data for PTGFRN Gene at MOPED

Post-translational modifications for PTGFRN Gene

  • Glycosylation at Asn 44, Ser 150, Asn 286, Asn 300, Asn 383, Asn 413, Asn 525, Asn 600, Asn 618, and Asn 691
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGFRN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTGFRN Gene

Domains & Families for PTGFRN Gene

Suggested Antigen Peptide Sequences for PTGFRN Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2B2

UniProtKB/Swiss-Prot:

FPRP_HUMAN :
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with PTGFRN: view

Function for PTGFRN Gene

Molecular function for PTGFRN Gene

GENATLAS Biochemistry:
prostaglandin F2 alpha receptor (FP),negative receptor
UniProtKB/Swiss-Prot Function:
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).

Phenotypes for PTGFRN Gene

GenomeRNAi human phenotypes for PTGFRN:
MGI mutant phenotypes for PTGFRN:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PTGFRN: view

Animal Model Products

miRNA for PTGFRN Gene

miRTarBase miRNAs that target PTGFRN

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTGFRN Gene

Localization for PTGFRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGFRN Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGFRN Gene COMPARTMENTS Subcellular localization image for PTGFRN gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 3
plasma membrane 3
extracellular 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 19581412
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTGFRN: view

Pathways & Interactions for PTGFRN Gene

SuperPathways for PTGFRN Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTGFRN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PTGFRN Gene

Drugs & Compounds for PTGFRN Gene

No Compound Related Data Available

Transcripts for PTGFRN Gene

mRNA/cDNA for PTGFRN Gene

Unigene Clusters for PTGFRN Gene

Prostaglandin F2 receptor inhibitor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGFRN Gene

No ASD Table

Relevant External Links for PTGFRN Gene

GeneLoc Exon Structure for
PTGFRN
ECgene alternative splicing isoforms for
PTGFRN

Expression for PTGFRN Gene

mRNA expression in normal human tissues for PTGFRN Gene

Protein differential expression in normal tissues from HIPED for PTGFRN Gene

This gene is overexpressed in Uterus (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGFRN Gene



SOURCE GeneReport for Unigene cluster for PTGFRN Gene Hs.418093

genes like me logo Genes that share expression patterns with PTGFRN: view

Protein tissue co-expression partners for PTGFRN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTGFRN Gene

Orthologs for PTGFRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGFRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGFRN 35
  • 99.35 (n)
  • 99.08 (a)
PTGFRN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGFRN 36
  • 89 (a)
OneToOne
PTGFRN 35
  • 87.84 (n)
  • 90.48 (a)
dog
(Canis familiaris)
Mammalia PTGFRN 35
  • 86.49 (n)
  • 88.48 (a)
PTGFRN 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgfrn 16
Ptgfrn 35
  • 86.35 (n)
  • 89.99 (a)
Ptgfrn 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGFRN 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGFRN 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgfrn 35
  • 85.59 (n)
  • 89.08 (a)
chicken
(Gallus gallus)
Aves PTGFRN 35
  • 66.74 (n)
  • 64.77 (a)
PTGFRN 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGFRN 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493252 35
  • 53.7 (n)
  • 43.46 (a)
zebrafish
(Danio rerio)
Actinopterygii PTGFRN (1 of 2) 36
  • 34 (a)
OneToMany
PTGFRN (2 of 2) 36
  • 38 (a)
OneToMany
si:ch211-132g1.7 35
  • 48.39 (n)
  • 35.91 (a)
Species with no ortholog for PTGFRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGFRN Gene

ENSEMBL:
Gene Tree for PTGFRN (if available)
TreeFam:
Gene Tree for PTGFRN (if available)

Paralogs for PTGFRN Gene

Paralogs for PTGFRN Gene

(1) SIMAP similar genes for PTGFRN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTGFRN: view

Variants for PTGFRN Gene

Sequence variations from dbSNP and Humsavar for PTGFRN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10801922 - 116,986,836(+) TCGGC(A/G)TCGGT reference, missense
rs4546904 - 116,945,089(+) AGCCA(A/T)CAGGT reference, missense
rs944 -- 116,990,176(+) ACTTT(C/G)TTTTT utr-variant-3-prime
rs11836 -- 116,989,750(-) TGAAA(A/C)ATCTC utr-variant-3-prime
rs13951 -- 116,988,998(+) GAACA(A/G)ATATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTGFRN Gene

Variant ID Type Subtype PubMed ID
nsv831159 CNV Loss 17160897
nsv2566 CNV Loss 18451855
nsv519074 CNV Loss 19592680

Variation tolerance for PTGFRN Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.36; 95.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGFRN Gene

HapMap Linkage Disequilibrium report
PTGFRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFRN Gene

Disorders for PTGFRN Gene

Relevant External Links for PTGFRN

Genetic Association Database (GAD)
PTGFRN
Human Genome Epidemiology (HuGE) Navigator
PTGFRN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGFRN

No disorders were found for PTGFRN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGFRN Gene

Publications for PTGFRN Gene

  1. Glycosylation status of the membrane protein CD9P-1. (PMID: 17960739) Andre M. … Le Naour F. (Proteomics 2007) 3 4 23 67
  2. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PMID: 17407154) Abache T. … Rubinstein E. (J. Cell. Biochem. 2007) 3 23
  3. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PMID: 16690612) Sala-ValdAcs M. … YA!A+ez-MA^ M. (J. Biol. Chem. 2006) 3 23
  4. FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. (PMID: 11087758) Stipp C.S. … Hemler M.E. (J. Biol. Chem. 2001) 3 23
  5. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PMID: 11278880) Charrin S. … Rubinstein E. (J. Biol. Chem. 2001) 3 23

Products for PTGFRN Gene

Sources for PTGFRN Gene

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