Aliases for PTGFRN Gene
Aliases for PTGFRN Gene
External Ids for PTGFRN Gene
- HGNC: 9601
- Entrez Gene: 5738
- Ensembl: ENSG00000134247
- OMIM: 601204
- UniProtKB: Q9P2B2
Previous GeneCards Identifiers for PTGFRN Gene
- GC01P117943
- GC01P116322
- GC01P116600
- GC01P116796
- GC01P116799
- GC01P117164
- GC01P117254
- GC01P117452
- GC01P115311
Summaries for PTGFRN Gene
GeneCards Summary for PTGFRN Gene
PTGFRN (Prostaglandin F2 Receptor Inhibitor) is a Protein Coding gene. Diseases associated with PTGFRN include Exudative Vitreoretinopathy. An important paralog of this gene is CD101.
UniProtKB/Swiss-Prot for PTGFRN Gene
-
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).
Additional gene information for PTGFRN Gene
- Monarch Initiative
- Search for PTGFRN at DataMed
- Search for PTGFRN at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGFRN Gene
Genomics for PTGFRN Gene
GeneHancer (GH) Regulatory Elements for PTGFRN Gene
Regulatory Element Products
Genomic Locations for PTGFRN Gene
- chr1:116,909,923-116,990,358
- (GRCh38/hg38)
- Size:
- 80,436 bases
- Orientation:
- Plus strand
- chr1:117,452,679-117,532,980
- (GRCh37/hg19)
Genomic View for PTGFRN Gene
- Cytogenetic band:
-
- 1p13.1 by Ensembl
- 1p13.1 by Entrez Gene
- 1p13.1 by HGNC


RefSeq DNA sequence for PTGFRN Gene
Proteins for PTGFRN Gene
-
Protein details for PTGFRN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P2B2-FPRP_HUMAN
- Recommended name:
- Prostaglandin F2 receptor negative regulator
- Protein Accession:
- Q9P2B2
- Q5VVU9
- Q8N2K6
Protein attributes for PTGFRN Gene
- Size:
- 879 amino acids
- Molecular mass:
- 98556 Da
- Quaternary structure:
-
- Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.
- SequenceCaution:
-
- Sequence=BAA92674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11104.1; Type=Erroneous termination; Positions=864; Note=Translated as Gln.; Evidence={ECO:0000305};
Protein Expression for PTGFRN Gene
Post-translational modifications for PTGFRN Gene
- Glycosylation at Asn44, isoforms=150, isoforms=286, isoforms=300, isoforms=383, Asn413, isoforms=525, Asn600, Asn618, and isoforms=691
Other Protein References for PTGFRN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PTGFRN (FPRP)
- Novus Biologicals Antibodies for PTGFRN
-
Abcam antibodies for PTGFRN
-
Cloud-Clone Corp. Antibodies for PTGFRN
- Invitrogen Antibodies for PTGFRN
- GeneTex PTGFRN antibody for PTGFRN
- Sino Biological Antibodies for PTGFRN
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PTGFRN
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- Novus Biologicals proteins for PTGFRN
- Sino Biological Recombinant Proteins for PTGFRN
- Sino Biological Cell Lysates for PTGFRN
-
Cloud-Clone Corp. Proteins for PTGFRN
- antibodies-online: Search results for 8 available PTGFRN Proteins ranked by validation data
- Compare Top PTGFRN Proteins
-
Quality Products:
- Search GeneTex for Proteins for PTGFRN
Assay Products
No data available for DME Specific Peptides for PTGFRN Gene
Domains & Families for PTGFRN Gene
Gene Families for PTGFRN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted membrane proteins
Protein Domains for PTGFRN Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGFRN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PTGFRN Gene
Function for PTGFRN Gene
Molecular function for PTGFRN Gene
- GENATLAS Biochemistry:
- prostaglandin F2 alpha receptor (FP),negative receptor
- UniProtKB/Swiss-Prot Function:
- Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).
Phenotypes From GWAS Catalog for PTGFRN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11278880 |
Phenotypes for PTGFRN Gene
- MGI mutant phenotypes for PTGFRN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTGFRN:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTGFRN
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGFRN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGFRN gene
- Search ViGene Biosciences for PTGFRN
CRISPR Products
-
OriGene CRISPR knockouts for PTGFRN
- genomics-online: gRNA clones - Search results for available PTGFRN gene related products
- Applied Biological Materials CRISPR for PTGFRN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGFRN
- GenScript: Design CRISPR guide RNA sequences for PTGFRN
miRNA for PTGFRN Gene
- miRTarBase miRNAs that target PTGFRN
-
- hsa-mir-30a-5p (MIRT005149)
- hsa-mir-24-3p (MIRT030461)
- hsa-mir-877-5p (MIRT037210)
- hsa-mir-615-3p (MIRT040204)
- hsa-mir-18a-3p (MIRT040958)
- hsa-mir-92a-3p (MIRT049140)
- hsa-let-7b-5p (MIRT051989)
- hsa-mir-218-5p (MIRT439872)
- hsa-mir-5196-5p (MIRT470044)
- hsa-mir-4747-5p (MIRT470045)
- hsa-mir-3185 (MIRT470046)
- hsa-mir-2115-3p (MIRT470047)
- hsa-mir-371a-3p (MIRT470048)
- hsa-mir-5197-3p (MIRT470049)
- hsa-mir-499b-3p (MIRT470050)
- hsa-mir-499a-3p (MIRT470051)
- hsa-mir-20a-5p (MIRT470052)
- hsa-mir-106a-5p (MIRT470053)
- hsa-mir-17-5p (MIRT470054)
- hsa-mir-20b-5p (MIRT470055)
- hsa-mir-106b-5p (MIRT470056)
- hsa-mir-93-5p (MIRT470057)
- hsa-mir-519d-3p (MIRT470058)
- hsa-mir-526b-3p (MIRT470059)
- hsa-mir-6780a-3p (MIRT639941)
- hsa-mir-7111-3p (MIRT639942)
- hsa-mir-6852-3p (MIRT639943)
- hsa-mir-3909 (MIRT639944)
- hsa-mir-1236-3p (MIRT639945)
- hsa-mir-877-3p (MIRT639946)
- hsa-mir-3922-5p (MIRT639947)
- hsa-mir-6881-3p (MIRT641970)
- hsa-mir-554 (MIRT641971)
- hsa-mir-6828-3p (MIRT687162)
- hsa-mir-23c (MIRT687163)
- hsa-mir-23b-3p (MIRT687164)
- hsa-mir-23a-3p (MIRT687165)
- hsa-mir-130a-5p (MIRT687166)
- hsa-mir-7151-3p (MIRT687167)
- hsa-mir-5095 (MIRT687168)
- hsa-mir-6502-5p (MIRT687169)
- hsa-mir-1301-5p (MIRT687170)
- hsa-mir-4522 (MIRT687171)
- hsa-mir-767-3p (MIRT687172)
- hsa-mir-6728-3p (MIRT687173)
- hsa-mir-139-5p (MIRT687174)
- hsa-mir-7112-5p (MIRT687175)
- hsa-mir-6812-3p (MIRT687176)
- hsa-mir-1972 (MIRT687177)
- hsa-mir-330-3p (MIRT687178)
- hsa-mir-15a-3p (MIRT687179)
- hsa-mir-4438 (MIRT687180)
- hsa-mir-6835-3p (MIRT687181)
miRNA Products
- Search ViGene Biosciences for PTGFRN
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGFRN
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-
ViGene Biosciences ready-to-package AAV shRNAs for PTGFRN gene
Clone Products
- Sino Biological Human cDNA Clone for PTGFRN
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- VectorBuilder custom plasmid, inducible vectors for PTGFRN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGFRN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PTGFRN gene related products
- orf clones - Search results for available PTGFRN gene related products
- Applied Biological Materials Clones for PTGFRN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PTGFRN
-
ViGene Biosciences adenoviral particle packaged cDNA for PTGFRN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGFRN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGFRN gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTGFRN Gene
Localization for PTGFRN Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGFRN Gene
- Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005886 | plasma membrane | IBA | -- |
GO:0009986 | cell surface | HDA,IDA | 19581412 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGFRN Gene
Pathways & Interactions for PTGFRN Gene
Interacting Proteins for PTGFRN Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0034389 | lipid particle organization | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PTGFRN Gene
Transcripts for PTGFRN Gene
mRNA/cDNA for PTGFRN Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (517) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTGFRN Gene
CRISPR Products
-
OriGene CRISPR knockouts for PTGFRN
- genomics-online: gRNA clones - Search results for available PTGFRN gene related products
- Applied Biological Materials CRISPR for PTGFRN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGFRN
- GenScript: Design CRISPR guide RNA sequences for PTGFRN
miRNA Products
- Search ViGene Biosciences for PTGFRN
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGFRN
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- genomics-online: shRNA clones - Search results for available PTGFRN gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGFRN gene
Clone Products
- Sino Biological Human cDNA Clone for PTGFRN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PTGFRN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGFRN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PTGFRN gene related products
- orf clones - Search results for available PTGFRN gene related products
- Applied Biological Materials Clones for PTGFRN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PTGFRN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Neural Tube (Nervous System)
- Floor Plate Cells Spinal Floor Plate
- Mesencephalic Ventricular Zone
- Telencephalon
- Spinal Floor Plate
- Metencephalon
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- Brain (Nervous System)
-
Stomach (Gastrointestinal Tract)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTGFRN Gene
NURSA nuclear receptor signaling pathways regulating expression of PTGFRN Gene:
PTGFRNSOURCE GeneReport for Unigene cluster for PTGFRN Gene:
Hs.418093Evidence on tissue expression from TISSUES for PTGFRN Gene
- Stomach(4.8)
- Nervous system(4.5)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for PTGFRN
- genomics-online: primer clones - Search results for available PTGFRN gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGFRN Gene
Orthologs for PTGFRN Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PTGFRN 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PTGFRN 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | PTGFRN 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ptgfrn 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ptgfrn 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PTGFRN 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | PTGFRN 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PTGFRN 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PTGFRN 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493252 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | si:ch211-132g1.7 33 |
|
||
PTGFRN (2 of 2) 34 |
|
OneToMany | |||
PTGFRN (1 of 2) 34 |
|
OneToMany |
- Species where no ortholog for PTGFRN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PTGFRN Gene
(1) SIMAP similar genes for PTGFRN Gene using alignment to 4 proteins:
Variants for PTGFRN Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000004302 | -- | 116,939,177(+) | T/C | intron_variant | |
rs1000026186 | -- | 116,964,695(+) | C/T | intron_variant | |
rs1000047226 | -- | 116,941,260(+) | G/A | intron_variant | |
rs1000101120 | -- | 116,912,539(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000183212 | -- | 116,915,739(+) | C/T | genic_upstream_transcript_variant, intron_variant |
Additional Variant Information for PTGFRN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PTGFRN
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFRN Gene
Disorders for PTGFRN Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
exudative vitreoretinopathy |
|
|
Additional Disease Information for PTGFRN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGFRN Gene
Publications for PTGFRN Gene
- Glycosylation status of the membrane protein CD9P-1. (PMID: 17960739) André M … Le Naour F (Proteomics 2007) 3 4 22 58
- The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PMID: 11278880) Charrin S … Rubinstein E (The Journal of biological chemistry 2001) 3 4 22 58
- Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns SL … Rosenstein BS (International journal of radiation oncology, biology, physics 2010) 3 44 58
- Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 44 58
- The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PMID: 17407154) Abache T … Rubinstein E (Journal of cellular biochemistry 2007) 3 22 58
Products for PTGFRN Gene
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- Invitrogen Antibodies for PTGFRN
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- VectorBuilder custom plasmid, inducible vectors for PTGFRN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGFRN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 37 available PTGFRN Antibodies ranked by validation data
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- antibodies-online: Search results for available PTGFRN related products ranked by validation data
- antibodies-online: Search results for 8 available PTGFRN Proteins ranked by validation data
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- Quality Products:
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- Search ViGene Biosciences for PTGFRN
- Horizon Cell Lines for PTGFRN
- genomics-online: cdna clones - Search results for available PTGFRN gene related products
- orf clones - Search results for available PTGFRN gene related products
- genomics-online: gRNA clones - Search results for available PTGFRN gene related products
- genomics-online: primer clones - Search results for available PTGFRN gene related products
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Sources for PTGFRN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
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