Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGFRN Gene

protein-coding   GIFtS: 60
GCID: GC01P117452

Prostaglandin F2 Receptor Inhibitor

(Previous name: prostaglandin F2 receptor negative regulator)
  4 related diseases
at
MalaCards
 

Aliases
for PTGFRN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Prostaglandin F2 Receptor Inhibitor1 2     CD9 Partner 12 3
FPRP2 3 5     CD3152
Prostaglandin F2 Receptor Negative Regulator1 2     SMAP-62
Glu-Trp-Ile EWI Motif-Containing Protein F2 3     CD9P13
Prostaglandin F2-Alpha Receptor Regulatory Protein2 3     EWIF3
Prostaglandin F2-Alpha Receptor-Associated Protein2 3     KIAA14363
CD9P-12 3     CD315 Antigen3
EWI-F2 3     

External Ids:    HGNC: 96011   Entrez Gene: 57382   Ensembl: ENSG000001342477   OMIM: 6012045   UniProtKB: Q9P2B23   

Export aliases for PTGFRN gene to outside databases

Previous GC identifers: GC01P117943 GC01P116322 GC01P116600 GC01P116796 GC01P116799 GC01P117164 GC01P117254 GC01P115311


Summaries
for PTGFRN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for PTGFRN Gene: 
PTGFRN (prostaglandin F2 receptor inhibitor) is a protein-coding gene. Diseases associated with PTGFRN include schizophrenia, and lung cancer. GO annotations related to this gene include protein binding. An important paralog of this gene is IGSF8.

UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
receptor seems to occur (By similarity)

Gene Wiki entry for PTGFRN Gene


Genomic Views
for PTGFRN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGFRN gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   GATA-1   RORalpha1   S8   E2F   E2F-1   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTGFRN promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGFRN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGFRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

PTGFRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGFRN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117452:  view genomic region     (about GC identifiers)

Start:
 117,452,679 bp from pter      End:
 117,532,980 bp from pter
Size:
 80,302 bases      Orientation:
 plus strand

Proteins
for PTGFRN gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2 (See protein sequence)
Recommended Name: Prostaglandin F2 receptor negative regulator precursor  
Size: 879 amino acids; 98556 Da
Subunit: Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Golgi
apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=BAA92674.1; Type=Erroneous initiation; Sequence=BAC11104.1; Type=Erroneous termination;
Positions=864; Note=Translated as Gln;
Secondary accessions: Q5VVU9 Q8N2K6

Explore the universe of human proteins at neXtProt for PTGFRN: NX_Q9P2B2

Explore proteomics data for PTGFRN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2B2

    • PTGFRN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGFRN Protein Expression
    REFSEQ proteins: NP_065173.2  
    ENSEMBL proteins: 
     ENSP00000376899  

    Human Recombinant Protein Products for PTGFRN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PTGFRN
    GenScript Custom Purified and Recombinant Proteins Services for PTGFRN
    Novus Biologicals PTGFRN Protein
    Sino Biological Recombinant Protein for PTGFRN
    Sino Biological Cell Lysate for PTGFRN 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGFRN 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016021integral to membrane IEA--

    PTGFRN for ontologies           About GeneDecksing



    PTGFRN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGFRN
    R&D Systems Antibodies for PTGFRN (FPRP)
    OriGene Antibodies for PTGFRN
    OriGene Custom Antibody Services for PTGFRN
    GenScript Custom Superior Antibodies Services for PTGFRN
    Novus Biologicals PTGFRN Antibodies
    Abcam antibodies for PTGFRN
    Cloud-Clone Corp. Antibodies for PTGFRN 
    ThermoFisher Antibody for PTGFRN
    LSBio Antibodies in human, mouse, rat for PTGFRN 

    Assay Products for PTGFRN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTGFRN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTGFRN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTGFRN 
    Cloud-Clone Corp. CLIAs for PTGFRN

    Protein Domains /
    Families
    for PTGFRN gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9P2B2

    ProtoNet protein and cluster: Q9P2B2

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    PTGFRN for domains           About GeneDecksing


    Function
    for PTGFRN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPRP_HUMAN, Q9P2B2
    Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
    the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
    receptor seems to occur (By similarity)

         Genatlas biochemistry entry for PTGFRN:
    prostaglandin F2 alpha receptor (FP),negative receptor

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278880
         
    PTGFRN for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ptgfrn):
     behavior/neurological 

    PTGFRN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGFRN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGFRN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGFRN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGFRN 

    miRNA
    Products:            		miRTarBase miRNAs that target PTGFRN:
    hsa-mir-30a (MIRT005149)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGFRN
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: PTGFRN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGFRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGFRN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PTGFRN
    Sirion Biotech Customized adenovirus for overexpression of PTGFRN

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTGFRN (see all 5)
    OriGene ORF clones in mouse, rat for PTGFRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGFRN (NM_020440)
    Sino Biological Human cDNA Clone for PTGFRN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGFRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGFRN
    Sirion Biotech Customized lentivirus for stable overexpression of PTGFRN 
                         Customized lentivirus expression plasmids for stable overexpression of PTGFRN 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PTGFRN
    Search LifeMap BioReagents cell lines for PTGFRN
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN


    Pathways & Interactions
    for PTGFRN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGFRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/28 Interacting proteins for PTGFRN (Q9P2B22, 3 ENSP000003768994) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD81P600332, 3, ENSP000002636454MINT-8407185 I2D: score=2 STRING: ENSP00000263645
    CD9P219262, 3, ENSP000000091804MINT-8407185 I2D: score=2 STRING: ENSP00000009180
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=2 STRING: ENSP00000257857
    CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
    CD82P277013, ENSP000002271554I2D: score=2 STRING: ENSP00000227155
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034389lipid particle organization IEA--

    PTGFRN for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTGFRN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTGFRN (FPRP)

    Search CenterWatch for drugs/clinical trials and news about PTGFRN / FPRP

    Transcripts
    for PTGFRN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTGFRN gene: 
    NM_020440.2  

    Unigene Cluster for PTGFRN:

    Prostaglandin F2 receptor inhibitor
    Hs.418093  [show with all ESTs]
    Unigene Representative Sequence: BC152454
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393203(uc001egv.1) ENST00000496699 ENST00000497385
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGFRN
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: PTGFRN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGFRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGFRN
    Clone
    Products:             		 OriGene clones in human, mouse for PTGFRN (see all 5)
    OriGene ORF clones in mouse, rat for PTGFRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGFRN (NM_020440)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGFRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGFRN
    Sirion Biotech Customized lentivirus for stable overexpression of PTGFRN 
                         Customized lentivirus expression plasmids for stable overexpression of PTGFRN 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for PTGFRN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGFRN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGFRN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGFRN

    Additional mRNA sequence: 

    AB014734.1 AB037857.1 AK001863.1 AK024785.1 AK074637.1 BC022235.1 BC042164.1 BC098142.1 
    BC114520.1 BC139718.1 BC152454.1 

    13 DOTS entries:

    DT.117499  DT.95085973  DT.100786281  DT.95153899  DT.100786280  DT.121432910  DT.121632648  DT.100786278 
    DT.121432942  DT.121608331  DT.91737304  DT.91756882  DT.91756884 

    24/517 AceView cDNA sequences (see all 517):

    AI829647 AW807990 AB014734 AW808052 AW276593 AI090820 AI419674 CB306568 
    BF063322 CD679141 BF222064 AA433926 AW808009 AB037857 NM_020440 AL135637 
    AA931766 W56614 BQ640041 BE551564 AW808040 AW808001 AW807998 W58002 

    GeneLoc Exon Structure


    Expression
    for PTGFRN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGFRN expression in normal human tissues (normalized intensities)      PTGFRN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTCAC
    PTGFRN Expression
    About this image


    PTGFRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             brain/forebrain/telencephalon   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-139
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus

    See PTGFRN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGFRN

    SOURCE GeneReport for Unigene cluster: Hs.418093
        SABiosciences Custom PCR Arrays for PTGFRN
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for PTGFRN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGFRN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGFRN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGFRN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN

    Orthologs
    for PTGFRN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PTGFRN gene from 10 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chimpanzee
    (Pan troglodytes)    		 Mammalia PTGFRN1 prostaglandin F2 receptor negative regulator 99.35(n)
    99.08(a)    		   747910  XM_003308312.1  XP_003308360.1 
    mouse
    (Mus musculus)    		 Mammalia Ptgfrn1 , 5 prostaglandin F2 receptor negative regulator1, 5 86.35(n)1
    89.99(a)1    		   3 (43.93 cM)5
    192211  NM_011197.31  NP_035327.21 
     1010402325 
    rat
    (Rattus norvegicus)    		 Mammalia Ptgfrn1 prostaglandin F2 receptor negative regulator 85.59(n)
    89.08(a)    		   29602  NM_019243.1  NP_062116.1 
    cow
    (Bos taurus)    		 Mammalia PTGFRN1 prostaglandin F2 receptor negative regulator 87.47(n)
    90.46(a)    		   538209  XM_002686122.1  XP_002686168.1 
    dog
    (Canis familiaris)    		 Mammalia PTGFRN1 prostaglandin F2 receptor negative regulator 87.06(n)
    89.9(a)    		   475809  XM_533018.3  XP_533018.3 
    oppossum
    (Monodelphis domestica)    		 Mammalia PTGFRN6
    		 prostaglandin F2 receptor inhibitor
    		 72(a)
    		 1 ↔ 1
    		 2(488739000-488824742)
    platypus
    (Ornithorhynchus anatinus)    		 Mammalia PTGFRN6
    		 prostaglandin F2 receptor inhibitor
    		 58(a)
    		 1 ↔ 1
    		 Contig13844(3405-17513)
    chicken
    (Gallus gallus)    		 Aves PTGFRN1 prostaglandin F2 receptor negative regulator 66.78(n)
    64.73(a)    		   418449  XM_416660.3  XP_416660.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PTGFRN6
    		 Uncharacterized protein
    		 62(a)
    		 1 ↔ 1
    		 3(162969244-163051159)
    zebrafish
    (Danio rerio)    		 Actinopterygii PTGFRN (1 of 2)6
    PTGFRN (2 of 2)6
    (see all 4)    		 prostaglandin F2 receptor inhibitor
    (see all 4)    		 38(a)
    34(a)
    (see all 4)    		 1 ↔ many
    1 ↔ many
    (see all 4)    		 9(494581-512906)
    1(1697817-1757143)
            Species with no ortholog for PTGFRN

    ENSEMBL Gene Tree for PTGFRN (if available)
    TreeFam Gene Tree for PTGFRN (if available)

    Paralogs
    for PTGFRN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGFRN gene
    IGSF82  IGSF32  CD1012  
    1 SIMAP similar gene for PTGFRN using alignment to 4 protein entries:     FPRP_HUMAN (see all proteins):
    smap-6

    PTGFRN for paralogs           About GeneDecksing



    Genomic Variants
    for PTGFRN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1586 SNPs in PTGFRN are shown (see all 1586)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1478994901,2
    		--115309318(+) TAGTGA/TATACA 1 -- us2k10--------
    rs1818678531,2
    		--115309378(+) TAAGCA/GTTCTG 1 -- us2k10--------
    rs1405140131,2
    		--115309382(+) CGTTCA/TGGGTG 1 -- us2k10--------
    rs1868682141,2
    		--117450704(+) CCTGCA/GAGATT 1 -- us2k10--------
    rs1913595111,2
    		--117450857(+) AAATTC/TTTTTT 1 -- us2k10--------
    rs2008932111,2
    		--117450930(+) AAAAA-/GAAAGA 1 -- us2k10--------
    rs1504350901,2
    		--117450951(+) AGAAGA/GAAAAG 1 -- us2k10--------
    rs24787651,2
    		C--117451033(+) AGGAGC/TTCGAG 1 -- us2k18Minor allele frequency- T:0.31WA NA CSA EA 365
    rs1832297751,2
    		--117451321(+) CCCCCA/GCCTCC 1 -- us2k10--------
    rs1853437271,2
    		--117451330(+) CCCCCG/TGCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTGFRN (117452679 - 117532980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTGFRN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519074CNV Loss19592680
    nsv2566CNV Loss18451855
    nsv831159CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTGFRN
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGFRN

    Disorders / Diseases
    for PTGFRN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 601204    OMIM disorders: --

    4 diseases for PTGFRN:    About MalaCards
    schizophrenia    lung cancer    prostate cancer    prostatitis


    PTGFRN for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PTGFRN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 17498801 (1)

    Genetic Association Database (GAD): PTGFRN
    Human Genome Epidemiology (HuGE) Navigator: PTGFRN (1 document)

    Export disorders for PTGFRN gene to outside databases

    Publications
    for PTGFRN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGFRN gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with PTGFRN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Glycosylation status of the membrane protein CD9P-1. (PubMed id 17960739)1, 2, 9 Andre M....Le Naour F. (2007)
    2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PubMed id 11278880)1, 2, 9 Charrin S.... Rubinstein E. (2001)
    3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (2010)
    4. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    7. Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. (PubMed id 8655148)1, 3 Orlicky D.J....Sikela J.M. (1996)
    8. FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. (PubMed id 11087758)1, 9 Stipp C.S....Hemler M.E. (2001)
    9. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PubMed id 17407154)1, 9 Abache T....Rubinstein E. (2007)
    10. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PubMed id 16690612)1, 9 Sala-Valdes M....Yanez-Mo M. (2006)

    External Searches for PTGFRN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTGFRN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5738 HGNC: 9601 AceView: PTGFRN Ensembl:ENSG00000134247 euGenes: HUgn5738
    ECgene: PTGFRN H-InvDB: PTGFRN

    Other Databases showing PTGFRN gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1436

    Specialized Databases showing PTGFRN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGFRN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PTGFRN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTGFRN gene:
    Search GeneIP for patents involving PTGFRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PTGFRN gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGFRN
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PTGFRN (FPRP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PTGFRN   OriGene RNAi products in human, mouse, rat for PTGFRN  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PTGFRN  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTGFRN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PTGFRN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTGFRN   OriGene Custom Protein Services for PTGFRN  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTGFRN
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTGFRN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGFRN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGFRN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGFRN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGFRN
     GenScript Custom Purified and Recombinant Proteins Services for PTGFRN GenScript cDNA clones with any tag delivered in your preferred vector for PTGFRN
     GenScript Custom Assay Services for PTGFRN GenScript Custom Superior Antibodies Services for PTGFRN
     GenScript Custom overexpressing Cell Line Services for PTGFRN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PTGFRN promoter
     Search Chromatin IP Primers for PTGFRN
     RT2 qPCR Primer Assay in human, mouse, rat PTGFRN
     GNC Network for PTGFRN
     SABiosciences Custom PCR Arrays for PTGFRN
     Search Tocris compounds for PTGFRN (FPRP)
     Proteins and Antibodies for PTGFRN
     Cell Lysates for PTGFRN
     cDNA Clones for PTGFRN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PTGFRN antibodies
     PTGFRN proteins
     Antibodies for PTGFRN
     See all of Abcam's Antibodies, Kits and Proteins for PTGFRN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PTGFRN
     Antibodies for PTGFRN
     ELISAs for PTGFRN
     CLIAs for PTGFRN
     Search LifeMap BioReagents cell lines for PTGFRN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN
     SwitchGear 3'UTR luciferase reporter plasmids for PTGFRN
     SwitchGear Promoter luciferase reporter plasmids for PTGFRN
     ThermoFisher Antibody for PTGFRN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGFRN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGFRN
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGFRN
    Customized:
     lentivirus for stable overexpression of PTGFRN
     lentivirus expression plasmids for stable overexpression of PTGFRN
     adenovirus for overexpression of PTGFRN
     LSBio Antibodies in human, mouse, rat for PTGFRN
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PTGFRN gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4