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PTGFRN Gene

protein-coding GIFtS: 60
GCID: GC01P117452

Prostaglandin F2 Receptor Inhibitor

(Previous name: prostaglandin F2 receptor negative regulator)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Prostaglandin F2 Receptor Inhibitor¹ ²		CD9 Partner 1² ³
FPRP² ³ ⁵		CD315²
Prostaglandin F2 Receptor Negative Regulator¹ ²		SMAP-6²
Glu-Trp-Ile EWI Motif-Containing Protein F² ³		CD9P1³
Prostaglandin F2-Alpha Receptor Regulatory Protein² ³		EWIF³
Prostaglandin F2-Alpha Receptor-Associated Protein² ³		KIAA1436³
CD9P-1² ³		CD315 Antigen³
EWI-F² ³

External Ids:	HGNC: 9601¹	Entrez Gene: 5738²	Ensembl: ENSG00000134247⁷	OMIM: 601204⁵	UniProtKB: Q9P2B2³

Export aliases for PTGFRN gene to outside databases

Previous GC identifers: GC01P117943 GC01P116322 GC01P116600 GC01P116796 GC01P116799 GC01P117164 GC01P117254 GC01P115311

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PTGFRN Gene:

PTGFRN (prostaglandin F2 receptor inhibitor) is a protein-coding gene. An important paralog of this gene is IGSF8.

UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2

Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing

the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha

receptor seems to occur (By similarity)

Gene Wiki entry for PTGFRN Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NC_018912.2 NT_032977.10

Regulatory elements:

Regulatory transcription factor binding sites in the PTGFRN gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 GATA-1 RORalpha1 S8 E2F E2F-1 COMP1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTGFRN promoter sequence

Search Chromatin IP Primers for PTGFRN

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGFRN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p13.1

PTGFRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGFRN gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P117452: view genomic region (about GC identifiers)

Start:	117,452,679 bp from pter	End:	117,532,980 bp from pter
Size:	80,302 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2 (See protein sequence)

Recommended Name: Prostaglandin F2 receptor negative regulator precursor

Size: 879 amino acids; 98556 Da

Subunit: Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151

Sequence caution: Sequence=BAA92674.1; Type=Erroneous initiation; Sequence=BAC11104.1; Type=Erroneous termination;

Positions=864; Note=Translated as Gln;

Secondary accessions: Q5VVU9 Q8N2K6

Explore the universe of human proteins at neXtProt for PTGFRN: NX_Q9P2B2

Explore proteomics data for PTGFRN at MOPED

Post-translational modifications:

Glycosylation² at Asn44, Ser150, Asn286, Asn300, Asn383, Asn413, Asn525, Asn600, Asn618, Asn691

Modification sites at PhosphoSitePlus

See PTGFRN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_065173.2

ENSEMBL proteins:

ENSP00000376899

PTGFRN Human Recombinant Protein Products:

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	antibodies-online peptides for PTGFRN

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	antibodies-online kits for PTGFRN (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

VSET: Immunoglobulin superfamily / V-set domain containing

4 InterPro protein domains:

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q9P2B2

ProtoNet protein and cluster: Q9P2B2

3 Blocks protein domains:

IPB003596 Immunoglobulin V-type

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2

Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains

Find genes that share domains with PTGFRN About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: FPRP_HUMAN, Q9P2B2

Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing

the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha

receptor seems to occur (By similarity)

Genatlas biochemistry entry for PTGFRN:

prostaglandin F2 alpha receptor (FP),negative receptor

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11278880

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Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ptgfrn):

behavior/neurological

Find genes that share phenotypes with PTGFRN About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for PTGFRN

miRNA Products:		miRTarBase miRNAs that target PTGFRN: hsa-let-7b-5p (MIRT051989), hsa-mir-92a-3p (MIRT049140), hsa-mir-24-3p (MIRT030461), hsa-mir-18a-3p (MIRT040958), hsa-mir-615-3p (MIRT040204), hsa-mir-877-5p (MIRT037210), hsa-mir-30a-5p (MIRT005149)

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

FPRP_HUMAN, Q9P2B2: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Golgi

apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
golgi apparatus	3
plasma membrane	3
extracellular	2
lysosome	1
peroxisome	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0016021	integral component of membrane	IEA	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PTGFRN
Interactions:

GeneGlobe Interaction Network for PTGFRN

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for PTGFRN (Q9P2B2^{2, 3} ENSP00000376899⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD81	P60033²^,³, ENSP00000263645⁴	MINT-8407185 I2D: score=2 STRING: ENSP00000263645
CD9	P21926²^,³, ENSP00000009180⁴	MINT-8407185 I2D: score=2 STRING: ENSP00000009180
CD63	P08962²^,³, ENSP00000257857⁴	MINT-8407185 I2D: score=2 STRING: ENSP00000257857
CD151	P48509³, ENSP00000324101⁴	I2D: score=2 STRING: ENSP00000324101
CD82	P27701³, ENSP00000227155⁴	I2D: score=2 STRING: ENSP00000227155

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0034389	lipid particle organization	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PTGFRN (FPRP)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PTGFRN gene:

NM_020440.2

Unigene Cluster for PTGFRN:

Prostaglandin F2 receptor inhibitor

Hs.418093 [show with all ESTs]

Unigene Representative Sequence: BC152454

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393203(uc001egv.1) ENST00000496699 ENST00000497385

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Additional mRNA sequence:

AB014734.1 AB037857.1 AK001863.1 AK024785.1 AK074637.1 BC022235.1 BC042164.1 BC098142.1

BC114520.1 BC139718.1 BC152454.1

13 DOTS entries:

DT.117499 DT.95085973 DT.100786281 DT.95153899 DT.100786280 DT.121432910 DT.121632648 DT.100786278

DT.121432942 DT.121608331 DT.91737304 DT.91756882 DT.91756884

Selected AceView cDNA sequences (see all 517):

BC063317 AA931766 W58002 W56614 CD679141 BE857712 CA314891 W57857

AI656398 AW808040 AA569727 AI262297 AI090820 AA036803 AI367905 AB014734

NM_020440 AW627596 AA433926 AI365353 AA826257 AW808004 AI417101 AW808052

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PTGFRN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTTTGTCAC

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PTGFRN expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Neural Tube (Nervous System) fully expand to see all 5 entries
Floor Plate Cells Spinal Floor Plate
Metencephalon

Thymus (Hematopoietic System)
T Helper Cells Thymus

Blood (Cardiovascular System)
T Helper Cells Thymus

Brain (Nervous System)
Medulla Oblongata

Stomach (Gastrointestinal Tract)

PTGFRN Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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PTGFRN Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.418093

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PTGFRN gene from 11 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	PTGFRN¹	prostaglandin F2 receptor negative regulator	99.35(n) 99.08(a)		747910 XM_003308312.1 XP_003308360.1
mouse (Mus musculus)	Mammalia	Ptgfrn^{1 , 5}	prostaglandin F2 receptor negative regulator^{1, 5}	86.35(n)¹ 89.99(a)¹		3 (43.93 cM)⁵ 19221¹ NM_011197.3¹ NP_035327.2¹ 101040232⁵
rat (Rattus norvegicus)	Mammalia	Ptgfrn¹	prostaglandin F2 receptor inhibitor	85.59(n) 89.08(a)		29602 NM_019243.1 NP_062116.1
cow (Bos taurus)	Mammalia	PTGFRN¹	prostaglandin F2 receptor inhibitor	87.84(n) 90.48(a)		538209 XM_002686122.2 XP_002686168.2
dog (Canis familiaris)	Mammalia	PTGFRN¹	prostaglandin F2 receptor inhibitor	86.49(n) 88.48(a)		475809 XM_005630873.1 XP_005630930.1
oppossum (Monodelphis domestica)	Mammalia	PTGFRN⁶	prostaglandin F2 receptor inhibitor	72(a)	1 ↔ 1	2(488739000-488824742)
platypus (Ornithorhynchus anatinus)	Mammalia	PTGFRN⁶	prostaglandin F2 receptor inhibitor	58(a)	1 ↔ 1	Contig13844(3405-17513)
chicken (Gallus gallus)	Aves	PTGFRN¹	prostaglandin F2 receptor negative regulator	66.74(n) 64.77(a)		418449 XM_416660.4 XP_416660.4
lizard (Anolis carolinensis)	Reptilia	PTGFRN⁶	prostaglandin F2 receptor inhibitor	62(a)	1 ↔ 1	3(162969244-163051159)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC100493252¹	prostaglandin F2 receptor negative regulator-like	53.7(n) 43.46(a)		100493252 XM_002943835.2 XP_002943881.2
zebrafish (Danio rerio)	Actinopterygii	si:ch211-132g1.7¹	si:ch211-132g1.7	48.39(n) 35.91(a)		101884699 XM_005168313.1 XP_005168370.1

Species with no ortholog for PTGFRN

ENSEMBL Gene Tree for PTGFRN (if available)
TreeFam Gene Tree for PTGFRN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PTGFRN gene

IGSF8² IGSF3² CD101²

1 SIMAP similar gene for PTGFRN using alignment to 4 protein entries: FPRP_HUMAN (see all proteins):

smap-6

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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147899490^1,2		--	115309318(+)	`TAGTGA/TATACA`	1	--	us2k¹		0	--	--	--	--
rs181867853^1,2		--	115309378(+)	`TAAGCA/GTTCTG`	1	--	us2k¹		0	--	--	--	--
rs140514013^1,2		--	115309382(+)	`CGTTCA/TGGGTG`	1	--	us2k¹		0	--	--	--	--
rs186868214^1,2		--	117450704(+)	`CCTGCA/GAGATT`	1	--	us2k¹		0	--	--	--	--
rs191359511^1,2		--	117450857(+)	`AAATTC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs200893211^1,2		--	117450930(+)	`AAAAA-/GAAAGA`	1	--	us2k¹		0	--	--	--	--
rs150435090^1,2		--	117450951(+)	`AGAAGA/GAAAAG`	1	--	us2k¹		0	--	--	--	--
rs2478765^1,2	C	--	117451033(+)	`AGGAGC/TTCGAG`	1	--	us2k¹		8		WA NA CSA EA	365
rs183229775^1,2		--	117451321(+)	`CCCCCA/GCCTCC`	1	--	us2k¹		0	--	--	--	--
rs185343727^1,2		--	117451330(+)	`CCCCCG/TGCCCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTGFRN (117452679 - 117532980 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for PTGFRN: About this table

Variant ID	Type	Subtype	PubMed ID
nsv519074	CNV	Loss	19592680
nsv2566	CNV	Loss	18451855
nsv831159	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PTGFRN

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601204 OMIM disorders: --

Find genes that share disorders with PTGFRN About GenesLikeMe

1 Novoseek inferred disease relationship for PTGFRN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	17498801 (1)

Genetic Association Database (GAD): PTGFRN
Human Genome Epidemiology (HuGE) Navigator: PTGFRN (1 document)

Export disorders for PTGFRN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PTGFRN gene, integrated from 10 sources (see all 28):
(articles sorted by number of sources associating them with PTGFRN)

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Glycosylation status of the membrane protein CD9P-1. (PubMed id 17960739)^{1, 2, 9} Andre M.... Le Naour F. (Proteomics 2007)
The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PubMed id 11278880)^{1, 2, 9} Charrin S.... Rubinstein E. (J. Biol. Chem. 2001)
Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PubMed id 19850283)^{1, 4} Ikeda M....Iwata N. (Biol. Psychiatry 2010)
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)^{1, 4} Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (DNA Res. 2000)
Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. (PubMed id 8655148)^{1, 3} Orlicky D.J....Sikela J.M. (Hum. Genet. 1996)
FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. (PubMed id 11087758)^{1, 9} Stipp C.S....Hemler M.E. (J. Biol. Chem. 2001)
The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PubMed id 17407154)^{1, 9} Abache T....Rubinstein E. (J. Cell. Biochem. 2007)
EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PubMed id 16690612)^{1, 9} Sala-ValdAcs M....YA!A+ez-MA^ M. (J. Biol. Chem. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5738	HGNC: 9601	AceView: PTGFRN	Ensembl:ENSG00000134247	euGenes: HUgn5738
ECgene: PTGFRN	H-InvDB: PTGFRN

(According to HUGE)
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HUGE: KIAA1436

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PTGFRN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PTGFRN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PTGFRN gene:
Search GeneIP for patents involving PTGFRN

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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