PTGFRN Gene

Aliases
for PTGFRN gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01P117943 GC01P116322 GC01P116600 GC01P116796 GC01P116799 GC01P117164 GC01P117254 GC01P115311

Summaries
for PTGFRN gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for PTGFRN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NC_018912.2  NT_032977.10  

SwitchGear Promoter luciferase reporter plasmid: PTGFRN promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGFRN

PTGFRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117452:  view genomic region     (about GC identifiers)

Proteins
for PTGFRN gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for PTGFRN: NX_Q9P2B2

Explore proteomics data for PTGFRN at MOPED

Post-translational modifications: 

PTGFRN Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for PTGFRN
	Search eBioscience for Proteins for PTGFRN
	Search GeneTex for Proteins for PTGFRN
	antibodies-online proteins for PTGFRN
	antibodies-online peptides for PTGFRN

PTGFRN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGFRN
	R&D Systems Antibodies for PTGFRN (FPRP)
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	Novus Biologicals PTGFRN Antibodies
	Abcam antibodies for PTGFRN
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	ThermoFisher Antibody for PTGFRN
	antibodies-online antibodies for PTGFRN (16 products)

PTGFRN Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PTGFRN Cloud-Clone Corp. CLIAs for PTGFRN
	Search eBioscience for ELISAs for PTGFRN
	antibodies-online kits for PTGFRN (6 products)

Domains /
Families
for PTGFRN gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9P2B2

Find genes that share domains with PTGFRN           About GenesLikeMe

Function
for PTGFRN gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Ptgfrn)

genOway: Develop your customized and physiologically relevant rodent model for PTGFRN

miRNA Products:		miRTarBase miRNAs that target PTGFRN: hsa-let-7b-5p (MIRT051989), hsa-mir-92a-3p (MIRT049140), hsa-mir-24-3p (MIRT030461), hsa-mir-18a-3p (MIRT040958), hsa-mir-615-3p (MIRT040204), hsa-mir-877-5p (MIRT037210), hsa-mir-30a-5p (MIRT005149)
		Block miRNA regulation of human, mouse, rat PTGFRN using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate PTGFRN (see all 100):
		hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
		SwitchGear 3'UTR luciferase reporter plasmid: PTGFRN 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PTGFRN
		Predesigned siRNA for gene silencing in human, mouse, rat PTGFRN

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PTGFRN

Clone Products:		OriGene clones in human, mouse for PTGFRN (see all 6) OriGene ORF clones in mouse, rat for PTGFRN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTGFRN (NM_020440)
		Sino Biological Human cDNA Clone for PTGFRN
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGFRN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGFRN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTGFRN
		Browse ESI BIO Cell Lines and PureStem Progenitors for PTGFRN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN

Localization
for PTGFRN gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
endoplasmic reticulum	5
golgi apparatus	3
plasma membrane	3
extracellular	2
lysosome	1
peroxisome	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for PTGFRN gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for PTGFRN gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for PTGFRN gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for PTGFRN gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PTGFRN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTTTGTCAC

About this image

Neural Tube (Nervous System)    fully expand to see all 5 entries
Floor Plate Cells Spinal Floor Plate
Metencephalon
Thymus (Hematopoietic System)
T Helper Cells Thymus
Blood (Cardiovascular System)
T Helper Cells Thymus
Brain (Nervous System)
Medulla Oblongata
Stomach (Gastrointestinal Tract)

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for PTGFRN
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTGFRN
		QuantiTect SYBR Green Assays in human, mouse, rat PTGFRN
		QuantiFast Probe-based Assays in human, mouse, rat PTGFRN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN

Orthologs
for PTGFRN gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for PTGFRN gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for PTGFRN gene

IGSF8²  IGSF3²  CD101²  

1 SIMAP similar gene for PTGFRN using alignment to 4 protein entries:     FPRP_HUMAN (see all proteins):

smap-6

Find genes that share paralogs with PTGFRN           About GenesLikeMe

Genomic Variants
for PTGFRN gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PTGFRN (see all 1586)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1478994901,2		--	115309318(+)	TAGTGA/TATACA	1	--	us2k1		0	--	--	--	--
rs1818678531,2		--	115309378(+)	TAAGCA/GTTCTG	1	--	us2k1		0	--	--	--	--
rs1405140131,2		--	115309382(+)	CGTTCA/TGGGTG	1	--	us2k1		0	--	--	--	--
rs1868682141,2		--	117450704(+)	CCTGCA/GAGATT	1	--	us2k1		0	--	--	--	--
rs1913595111,2		--	117450857(+)	AAATTC/TTTTTT	1	--	us2k1		0	--	--	--	--
rs2008932111,2		--	117450930(+)	AAAAA-/GAAAGA	1	--	us2k1		0	--	--	--	--
rs1504350901,2		--	117450951(+)	AGAAGA/GAAAAG	1	--	us2k1		0	--	--	--	--
rs24787651,2	C	--	117451033(+)	AGGAGC/TTCGAG	1	--	us2k1		8		WA NA CSA EA	365
rs1832297751,2		--	117451321(+)	CCCCCA/GCCTCC	1	--	us2k1		0	--	--	--	--
rs1853437271,2		--	117451330(+)	CCCCCG/TGCCCC	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTGFRN (117452679 - 117532980 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for PTGFRN:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv519074	CNV	Loss	19592680
nsv2566	CNV	Loss	18451855
nsv831159	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PTGFRN

DNA2.0 Custom Variant and Variant Library Synthesis for PTGFRN

Disorders / Diseases
for PTGFRN gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 Novoseek inferred disease relationship for PTGFRN gene    About this table

Publications
for PTGFRN gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Glycosylation status of the membrane protein CD9P-1. (PubMed id 17960739)^{1, 2, 9} Andre M.... Le Naour F. (Proteomics 2007)
2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PubMed id 11278880)^{1, 2, 9} Charrin S.... Rubinstein E. (J. Biol. Chem. 2001)
3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PubMed id 19850283)^{1, 4} Ikeda M....Iwata N. (Biol. Psychiatry 2010)
4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)^{1, 4} Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (DNA Res. 2000)
7. Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. (PubMed id 8655148)^{1, 3} Orlicky D.J....Sikela J.M. (Hum. Genet. 1996)
8. FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. (PubMed id 11087758)^{1, 9} Stipp C.S....Hemler M.E. (J. Biol. Chem. 2001)
9. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PubMed id 17407154)^{1, 9} Abache T....Rubinstein E. (J. Cell. Biochem. 2007)
10. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PubMed id 16690612)^{1, 9} Sala-ValdAcs M....YA!A+ez-MA^ M. (J. Biol. Chem. 2006)

External Searches for PTGFRN gene

Genome Databases showing PTGFRN gene

Other Databases showing PTGFRN gene

Specialized Databases showing PTGFRN gene

Products
for PTGFRN gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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