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Aliases for PTGFRN Gene

Aliases for PTGFRN Gene

  • Prostaglandin F2 Receptor Inhibitor 2 3
  • FPRP 3 4 6
  • Prostaglandin F2-Alpha Receptor Regulatory Protein 3 4
  • Prostaglandin F2-Alpha Receptor-Associated Protein 3 4
  • Prostaglandin F2 Receptor Negative Regulator 2 3
  • Glu-Trp-Ile EWI Motif-Containing Protein F 3 4
  • CD9 Partner 1 3 4
  • CD9P-1 3 4
  • EWI-F 3 4
  • CD315 Antigen 4
  • KIAA1436 4
  • SMAP-6 3
  • CD315 3
  • CD9P1 4
  • EWIF 4

External Ids for PTGFRN Gene

Previous GeneCards Identifiers for PTGFRN Gene

  • GC01P117943
  • GC01P116322
  • GC01P116600
  • GC01P116796
  • GC01P116799
  • GC01P117164
  • GC01P117254
  • GC01P117452
  • GC01P115311

Summaries for PTGFRN Gene

GeneCards Summary for PTGFRN Gene

PTGFRN (Prostaglandin F2 Receptor Inhibitor) is a Protein Coding gene. An important paralog of this gene is IGSF3.

UniProtKB/Swiss-Prot for PTGFRN Gene

  • Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).

Gene Wiki entry for PTGFRN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGFRN Gene

Genomics for PTGFRN Gene

Regulatory Elements for PTGFRN Gene

Genomic Location for PTGFRN Gene

Start:
116,910,057 bp from pter
End:
116,990,358 bp from pter
Size:
80,302 bases
Orientation:
Plus strand

Genomic View for PTGFRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGFRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGFRN Gene

Proteins for PTGFRN Gene

  • Protein details for PTGFRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2B2-FPRP_HUMAN
    Recommended name:
    Prostaglandin F2 receptor negative regulator
    Protein Accession:
    Q9P2B2
    Secondary Accessions:
    • Q5VVU9
    • Q8N2K6

    Protein attributes for PTGFRN Gene

    Size:
    879 amino acids
    Molecular mass:
    98556 Da
    Quaternary structure:
    • Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.
    SequenceCaution:
    • Sequence=BAA92674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11104.1; Type=Erroneous termination; Positions=864; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for PTGFRN Gene

Proteomics data for PTGFRN Gene at MOPED

Post-translational modifications for PTGFRN Gene

  • Glycosylation at Asn44, Ser150, Asn286, Asn300, Asn383, Asn413, Asn525, Asn600, Asn618, and Asn691
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGFRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGFRN Gene

Domains for PTGFRN Gene

Gene Families for PTGFRN Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Suggested Antigen Peptide Sequences for PTGFRN Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2B2

UniProtKB/Swiss-Prot:

FPRP_HUMAN :
  • Q9P2B2
Domain:
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with PTGFRN: view

Function for PTGFRN Gene

Molecular function for PTGFRN Gene

GENATLAS Biochemistry: prostaglandin F2 alpha receptor (FP),negative receptor
UniProtKB/Swiss-Prot Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).

Gene Ontology (GO) - Molecular Function for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278880
genes like me logo Genes that share ontologies with PTGFRN: view

Phenotypes for PTGFRN Gene

MGI mutant phenotypes for PTGFRN:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PTGFRN: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PTGFRN Gene

Localization for PTGFRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGFRN Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGFRN Gene COMPARTMENTS Subcellular localization image for PTGFRN gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
plasma membrane 3
extracellular 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0009986 cell surface IDA 19581412
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTGFRN: view

Pathways for PTGFRN Gene

SuperPathways for PTGFRN Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034389 lipid particle organization IEA --
genes like me logo Genes that share ontologies with PTGFRN: view

No data available for Pathways by source for PTGFRN Gene

Transcripts for PTGFRN Gene

mRNA/cDNA for PTGFRN Gene

Unigene Clusters for PTGFRN Gene

Prostaglandin F2 receptor inhibitor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGFRN Gene

No ASD Table

Relevant External Links for PTGFRN Gene

GeneLoc Exon Structure for
PTGFRN
ECgene alternative splicing isoforms for
PTGFRN

Expression for PTGFRN Gene

mRNA expression in normal human tissues for PTGFRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGFRN Gene

SOURCE GeneReport for Unigene cluster for PTGFRN Gene Hs.418093

genes like me logo Genes that share expressions with PTGFRN: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PTGFRN Gene

Orthologs for PTGFRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGFRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGFRN 35
  • 99.35 (n)
  • 99.08 (a)
PTGFRN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGFRN 35
  • 87.84 (n)
  • 90.48 (a)
PTGFRN 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGFRN 35
  • 86.49 (n)
  • 88.48 (a)
PTGFRN 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgfrn 35
  • 86.35 (n)
  • 89.99 (a)
Ptgfrn 16
Ptgfrn 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGFRN 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGFRN 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgfrn 35
  • 85.59 (n)
  • 89.08 (a)
chicken
(Gallus gallus)
Aves PTGFRN 35
  • 66.74 (n)
  • 64.77 (a)
PTGFRN 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGFRN 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493252 35
  • 53.7 (n)
  • 43.46 (a)
zebrafish
(Danio rerio)
Actinopterygii PTGFRN (1 of 2) 36
  • 34 (a)
OneToMany
PTGFRN (2 of 2) 36
  • 38 (a)
OneToMany
si:ch211-132g1.7 35
  • 48.39 (n)
  • 35.91 (a)
Species with no ortholog for PTGFRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGFRN Gene

ENSEMBL:
Gene Tree for PTGFRN (if available)
TreeFam:
Gene Tree for PTGFRN (if available)

Paralogs for PTGFRN Gene

Paralogs for PTGFRN Gene

Selected SIMAP similar genes for PTGFRN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTGFRN: view

Variants for PTGFRN Gene

Sequence variations from dbSNP and Humsavar for PTGFRN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs944 -- 116,990,176(+) ACTTT(C/G)TTTTT utr-variant-3-prime
rs3885 -- 116,987,651(+) ATGGC(A/C/G)GCCCT utr-variant-3-prime
rs6589 -- 116,990,269(+) TGAAC(C/T)AATTG utr-variant-3-prime
rs8254 -- 116,989,669(+) CCTGT(A/G)AATTG utr-variant-3-prime
rs11836 -- 116,989,750(-) TGAAA(A/C)ATCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTGFRN Gene

Variant ID Type Subtype PubMed ID
nsv831159 CNV Loss 17160897
nsv2566 CNV Loss 18451855
nsv519074 CNV Loss 19592680

Relevant External Links for PTGFRN Gene

HapMap Linkage Disequilibrium report
PTGFRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFRN Gene

Disorders for PTGFRN Gene

(1) Novoseek inferred disease relationships for PTGFRN Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for PTGFRN

Genetic Association Database (GAD)
PTGFRN
Human Genome Epidemiology (HuGE) Navigator
PTGFRN
genes like me logo Genes that share disorders with PTGFRN: view

No data available for UniProtKB/Swiss-Prot for PTGFRN Gene

Publications for PTGFRN Gene

  1. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PMID: 11278880) Charrin S. … Rubinstein E. (J. Biol. Chem. 2001) 3 4 23
  2. Glycosylation status of the membrane protein CD9P-1. (PMID: 17960739) Andre M. … Le Naour F. (Proteomics 2007) 3 4 23
  3. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PMID: 16690612) Sala-ValdAcs M. … YA!A+ez-MA^ M. (J. Biol. Chem. 2006) 3 23
  4. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PMID: 17407154) Abache T. … Rubinstein E. (J. Cell. Biochem. 2007) 3 23
  5. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. (PMID: 11673522) Clark K.L. … Todd S.C. (J. Immunol. 2001) 3 23

Products for PTGFRN Gene

Sources for PTGFRN Gene

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