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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGFRN Gene

protein-coding   GIFtS: 60
GCID: GC01P117452

Prostaglandin F2 Receptor Inhibitor

(Previous name: prostaglandin F2 receptor negative regulator)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prostaglandin F2 Receptor Inhibitor1 2     CD9 Partner 12 3
FPRP2 3 5     CD3152
Prostaglandin F2 Receptor Negative Regulator1 2     SMAP-62
Glu-Trp-Ile EWI Motif-Containing Protein F2 3     CD9P13
Prostaglandin F2-Alpha Receptor Regulatory Protein2 3     EWIF3
Prostaglandin F2-Alpha Receptor-Associated Protein2 3     KIAA14363
CD9P-12 3     CD315 Antigen3
EWI-F2 3     

External Ids:    HGNC: 96011   Entrez Gene: 57382   Ensembl: ENSG000001342477   OMIM: 6012045   UniProtKB: Q9P2B23   

Export aliases for PTGFRN gene to outside databases

Previous GC identifers: GC01P117943 GC01P116322 GC01P116600 GC01P116796 GC01P116799 GC01P117164 GC01P117254 GC01P115311


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PTGFRN Gene: 
PTGFRN (prostaglandin F2 receptor inhibitor) is a protein-coding gene. Diseases associated with PTGFRN include schizophrenia, and lung cancer. GO annotations related to this gene include protein binding. An important paralog of this gene is IGSF8.

UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
receptor seems to occur (By similarity)

Gene Wiki entry for PTGFRN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGFRN gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   GATA-1   RORalpha1   S8   E2F   E2F-1   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGFRN promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGFRN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGFRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

PTGFRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGFRN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117452:  view genomic region     (about GC identifiers)

Start:
117,452,679 bp from pter      End:
117,532,980 bp from pter
Size:
80,302 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2 (See protein sequence)
Recommended Name: Prostaglandin F2 receptor negative regulator precursor  
Size: 879 amino acids; 98556 Da
Subunit: Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Golgi
apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=BAA92674.1; Type=Erroneous initiation; Sequence=BAC11104.1; Type=Erroneous termination;
Positions=864; Note=Translated as Gln;
Secondary accessions: Q5VVU9 Q8N2K6

Explore the universe of human proteins at neXtProt for PTGFRN: NX_Q9P2B2

Explore proteomics data for PTGFRN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2B2

  • PTGFRN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGFRN Protein Expression
    REFSEQ proteins: NP_065173.2  
    ENSEMBL proteins: 
     ENSP00000376899  

    Human Recombinant Protein Products for PTGFRN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PTGFRN
    GenScript Custom Purified and Recombinant Proteins Services for PTGFRN
    Novus Biologicals PTGFRN Protein
    Sino Biological Recombinant Protein for PTGFRN
    Sino Biological Cell Lysate for PTGFRN 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGFRN 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016021integral to membrane IEA--

    PTGFRN for ontologies           About GeneDecksing



    PTGFRN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGFRN
    R&D Systems Antibodies for PTGFRN (FPRP)
    OriGene Antibodies for PTGFRN
    OriGene Custom Antibody Services for PTGFRN
    GenScript Custom Superior Antibodies Services for PTGFRN
    Novus Biologicals PTGFRN Antibodies
    Abcam antibodies for PTGFRN
    Cloud-Clone Corp. Antibodies for PTGFRN 
    ThermoFisher Antibody for PTGFRN
    LSBio Antibodies in human, mouse, rat for PTGFRN 

    Assay Products for PTGFRN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTGFRN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTGFRN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTGFRN 
    Cloud-Clone Corp. CLIAs for PTGFRN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9P2B2

    ProtoNet protein and cluster: Q9P2B2

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    PTGFRN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPRP_HUMAN, Q9P2B2
    Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
    the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
    receptor seems to occur (By similarity)

         Genatlas biochemistry entry for PTGFRN:
    prostaglandin F2 alpha receptor (FP),negative receptor

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278880
         
    PTGFRN for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ptgfrn):
     behavior/neurological 

    PTGFRN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGFRN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGFRN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGFRN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGFRN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTGFRN:
    hsa-mir-30a (MIRT005149)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGFRN
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidPTGFRN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGFRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGFRN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTGFRN
    Sirion Biotech Customized adenovirus for overexpression of PTGFRN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTGFRN (see all 5)
    OriGene ORF clones in mouse, rat for PTGFRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGFRN (NM_020440)
    Sino Biological Human cDNA Clone for PTGFRN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGFRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGFRN
    Sirion Biotech Customized lentivirus for stable overexpression of PTGFRN 
                         Customized lentivirus expression plasmids for stable overexpression of PTGFRN 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PTGFRN
    Search LifeMap BioReagents cell lines for PTGFRN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGFRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/28 Interacting proteins for PTGFRN (Q9P2B22, 3 ENSP000003768994) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD81P600332, 3, ENSP000002636454MINT-8407185 I2D: score=2 STRING: ENSP00000263645
    CD9P219262, 3, ENSP000000091804MINT-8407185 I2D: score=2 STRING: ENSP00000009180
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=2 STRING: ENSP00000257857
    CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
    CD82P277013, ENSP000002271554I2D: score=2 STRING: ENSP00000227155
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034389lipid particle organization IEA--

    PTGFRN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTGFRN (FPRP)

    Search CenterWatch for drugs/clinical trials and news about PTGFRN / FPRP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTGFRN gene: 
    NM_020440.2  

    Unigene Cluster for PTGFRN:

    Prostaglandin F2 receptor inhibitor
    Hs.418093  [show with all ESTs]
    Unigene Representative Sequence: BC152454
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393203(uc001egv.1) ENST00000496699 ENST00000497385
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGFRN
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidPTGFRN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGFRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGFRN
    Clone
    Products:
         
    OriGene clones in human, mouse for PTGFRN (see all 5)
    OriGene ORF clones in mouse, rat for PTGFRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGFRN (NM_020440)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGFRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGFRN
    Sirion Biotech Customized lentivirus for stable overexpression of PTGFRN 
                         Customized lentivirus expression plasmids for stable overexpression of PTGFRN 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PTGFRN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGFRN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGFRN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGFRN

    Additional mRNA sequence: 

    AB014734.1 AB037857.1 AK001863.1 AK024785.1 AK074637.1 BC022235.1 BC042164.1 BC098142.1 
    BC114520.1 BC139718.1 BC152454.1 

    13 DOTS entries:

    DT.117499  DT.95085973  DT.100786281  DT.95153899  DT.100786280  DT.121432910  DT.121632648  DT.100786278 
    DT.121432942  DT.121608331  DT.91737304  DT.91756882  DT.91756884 

    517 AceView cDNA sequences (see top 24):

    AI829647 AW807990 AB014734 AW808052 AW276593 AI090820 AI419674 CB306568 
    BF063322 CD679141 BF222064 AA433926 AW808009 AB037857 NM_020440 AL135637 
    AA931766 W56614 BQ640041 BE551564 AW808040 AW808001 AW807998 W58002 
    CA314891 AI079502 AA036803 AA569727 AI636636 AI972169 AW627596 BM999645 
    AI367905 AW808012 BE857128 AW808023 AI474355 BC022235 AA826257 AI365353 
    BE857712 BC063317 AI417101 AI262297 AI656398 AW808162 AW808191 AW808004 
    AW808048 W57857 CB241375 BM692433 AW808066 R71365 Z38697 CB265454 
    AI421845 CA448681 CA445365 AI591362 AW808073 Z42502 AW808000 AW808201 
    W33022 AW808110 AJ709972 CD679516 N32364 CD657195 AI744142 AU135751 
    AA972908 AA577019 BM794172 AW808014 AA578532 AI004738 AI953818 AW807991 
    T49390 AW136055 AW808049 BQ015227 AW808064 AW808020 AW808005 AA045156 
    AW808046 AK001863 AA478705 AI656409 AW808177 BF342215 W56644 CF139708 
    AI582364 AI813323 AW808185 AI160497 AA579572 BQ024934 CB960904 W81243 
    BX484024 AW808008 AA527437 AK074637 BG762047 N63283 AW808102 AW808135 
    AW808108 AW808035 AJ707126 BF108807 N29261 AI657082 BQ362684 AI160499 
    CA414342 AW808036 BC042164 AA430582 CB126045 AW807997 AW808138 AA631315 
    AI086286 AA527866 CA443926 AW150211 BM990205 AW808129 CA428896 AI694579 
    AI334010 N20548 AW808106 AW808194 AA860279 AW808007 AW808011 AA928515 
    AW808202 AA337498 AA427887 AW808029 AI342575 AW808107 BX472912 AI346360 
    AW138104 AI339563 AW807996 AW808041 AW808104 AW808141 AW808111 AW808026 
    AA733069 AW808113 BE747016 BG742994 AW808010 AW808161 BQ023279 BX504980 
    AW808203 AI289773 BF476250 AW952618 AW808137 AI049790 BM664025 AW808192 
    BG056279 CB051980 BG680204 CB989776 W81707 AW808193 CF265176 AW808131 
    AA576818 BM126936 AW808017 AA427970 AW807993 CA424158 BF205212 AA587900 
    BU753136 BF032559 AW808182 AW808195 BG681929 BM786196 CA447304 AK024785 
    AW808127 AW808070 AW808109 AW808074 AW808002 AA991901 AA131258 AW008770 
    AW808259 AW807980 AW808196 AW808059 AW808120 AW807974 AW807994 BG926162 
    BE763981 AW808037 AW808315 AW808163 AW808210 AW808174 AA380041 AA994540 
    AW808128 AW808173 AI174534 H39629 AW808069 W33023 AW808068 AW808025 
    AW808335 AW808231 AW808153 AW808019 AW808154 AV647561 AW808142 AW808112 
    H39788 CB134805 R39414 AW808072 AW807970 AA779619 BE858153 AW808065 
    AW808224 AW808080 BI259300 H52228 CB158037 BQ362676 AW808047 AW808058 
    AW808176 AW808121 AW808198 AW028975 AW808056 AA045111 BG167981 AW808169 
    AW808178 AW808175 AW808055 R71366 CD102506 AW808209 CB989984 AW808057 
    AI970282 BF109637 AW808100 AW808208 AW590534 AW808147 AW808239 AW808031 
    AW808279 AW808227 AW808165 AW808299 AA953913 AW808189 AI651480 AW807992 
    AW808039 AI832307 AW808071 AW808117 AW808038 AA456344 R38331 AW808180 
    CK818740 AW808184 AW364807 AW808237 BQ362758 BQ362680 AW808212 AJ709983 
    AW807972 AW808321 AW808155 AW808190 BQ362759 BG680733 AW808160 BQ363028 
    AW808263 AW808264 AW808090 AU156253 W20412 BQ187980 AA334316 AW808199 
    AW808340 AW808116 AW364806 BM752150 AI952215 AA099551 AW808149 BQ362682 
    AW629585 D79826 AW807968 BQ311905 AW808339 H94529 T78348 AW808285 
    N23384 R50483 AA101988 AW808313 BG896461 AW808197 AW613176 AV687966 
    R48561 BQ363027 AW808088 AW808187 AW808200 AW808277 AW807978 AW808082 
    AW808103 AW808099 AW808164 AW808060 AW808245 AW808303 AW083749 AW808229 
    AW808013 AW808170 AL527521 AW808304 AW808286 R40643 AW808097 AW808248 
    R48657 AW808145 AW808151 R63083 AW808281 AW808336 AW808215 AW808276 
    AW808269 AW808275 BE763971 AW808241 BF947446 AW808300 AW808114 BX486309 
    AW808034 AW807999 AW808168 R69994 AW808083 AW808260 AW808094 H11657 
    AW808311 AW808322 R14224 AW808324 AW808181 AW808207 BQ362448 AW808312 
    AW808246 AW808235 AW364809 R42921 AW808288 AW808140 AW808214 AW808317 
    AW808093 AW808205 N89036 BQ362683 AW808061 AW808050 AW808150 BF588488 
    AW807979 AW808270 AW808134 N83258 AW808236 BE926021 AW608541 AW808084 
    AW808290 AW807995 AW808247 AW808101 AW808211 AW808144 BE503768 AW808133 
    AW808228 AW808119 AW808323 AW808032 AW808295 BI460322 BQ363150 AW808255 
    AW808085 AW808188 R63127 BF435727 R69995 AW808331 AW808092 AW808287 
    AW808087 BQ362681 AW808250 AW808030 AW808015 AW808326 BQ363051 BF735440 
    BQ363235 AW808095 AW808252 BF735231 BQ362757 AW808332 AW808256 T49389 
    AW808296 AW808006 R50571 AW807973 AW808206 AW808292 AW808291 BQ314837 
    AW808132 AW808319 AW808283 AW808159 AW808044 AW808328 AW808225 AW808243 
    AW808062 BQ362677 AW808251 AW808171 AW808327 AW808157 CB050496 AW952538 
    AW807975 H12186 AW808204 AW808183 AW807963 AW808298 AW808139 BQ363237 
    BQ363053 R17584 AW808226 AL527520 AW808334 AW808258 AW808320 AW807971 
    AW937185 AW808018 BF752970 AW808284 BQ363152 AW808244 BG827669 AW381625 
    BG978079 AW808045 H52319 BF832750 BF154659 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGFRN expression in normal human tissues (normalized intensities)      PTGFRN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTCAC
    PTGFRN Expression
    About this image


    PTGFRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             brain/forebrain/telencephalon   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-139
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus

    See PTGFRN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGFRN

    SOURCE GeneReport for Unigene cluster: Hs.418093
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PTGFRN gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgfrn1 , 5 prostaglandin F2 receptor negative regulator1, 5 86.35(n)1
    89.99(a)1
      3 (43.93 cM)5
    192211  NM_011197.31  NP_035327.21 
     1010402325 
    chicken
    (Gallus gallus)
    Aves PTGFRN1 prostaglandin F2 receptor negative regulator 66.78(n)
    64.73(a)
      418449  XM_416660.3  XP_416660.3 
    lizard
    (Anolis carolinensis)
    Reptilia PTGFRN6
    Uncharacterized protein
    62(a)
    1 ↔ 1
    3(162969244-163051159)
    zebrafish
    (Danio rerio)
    Actinopterygii PTGFRN (1 of 2)6
    PTGFRN (2 of 2)6
    (see all 4)
    prostaglandin F2 receptor inhibitor
    (see all 4)
    38(a)
    34(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    9(494581-512906)
    1(1697817-1757143)


    ENSEMBL Gene Tree for PTGFRN (if available)
    TreeFam Gene Tree for PTGFRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGFRN gene
    IGSF82  IGSF32  CD1012  
    1 SIMAP similar gene for PTGFRN using alignment to 4 protein entries:     FPRP_HUMAN (see all proteins):
    smap-6

    PTGFRN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1586 SNPs in PTGFRN are shown (see all 1586)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478994901,2
    --115309318(+) TAGTGA/TATACA 1 -- us2k10--------
    rs1818678531,2
    --115309378(+) TAAGCA/GTTCTG 1 -- us2k10--------
    rs1405140131,2
    --115309382(+) CGTTCA/TGGGTG 1 -- us2k10--------
    rs1868682141,2
    --117450704(+) CCTGCA/GAGATT 1 -- us2k10--------
    rs1913595111,2
    --117450857(+) AAATTC/TTTTTT 1 -- us2k10--------
    rs2008932111,2
    --117450930(+) AAAAA-/GAAAGA 1 -- us2k10--------
    rs1504350901,2
    --117450951(+) AGAAGA/GAAAAG 1 -- us2k10--------
    rs24787651,2
    C--117451033(+) AGGAGC/TTCGAG 1 -- us2k18Minor allele frequency- T:0.31WA NA CSA EA 365
    rs1832297751,2
    --117451321(+) CCCCCA/GCCTCC 1 -- us2k10--------
    rs1853437271,2
    --117451330(+) CCCCCG/TGCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTGFRN (117452679 - 117532980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTGFRN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519074CNV Loss19592680
    nsv2566CNV Loss18451855
    nsv831159CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601204    OMIM disorders: --

    4 diseases for PTGFRN:    About MalaCards
    schizophrenia    lung cancer    prostate cancer    prostatitis


    PTGFRN for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PTGFRN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 17498801 (1)

    Genetic Association Database (GAD): PTGFRN
    Human Genome Epidemiology (HuGE) Navigator: PTGFRN (1 document)

    Export disorders for PTGFRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGFRN gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with PTGFRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glycosylation status of the membrane protein CD9P-1. (PubMed id 17960739)1, 2, 9 Andre M....Le Naour F. (2007)
    2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PubMed id 11278880)1, 2, 9 Charrin S.... Rubinstein E. (2001)
    3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (2010)
    4. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    7. Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. (PubMed id 8655148)1, 3 Orlicky D.J....Sikela J.M. (1996)
    8. FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. (PubMed id 11087758)1, 9 Stipp C.S....Hemler M.E. (2001)
    9. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PubMed id 17407154)1, 9 Abache T....Rubinstein E. (2007)
    10. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PubMed id 16690612)1, 9 Sala-Valdes M....Yanez-Mo M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5738 HGNC: 9601 AceView: PTGFRN Ensembl:ENSG00000134247 euGenes: HUgn5738
    ECgene: PTGFRN H-InvDB: PTGFRN

    (According to HUGE)
    About This Section
    HUGE: KIAA1436

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGFRN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTGFRN gene:
    Search GeneIP for patents involving PTGFRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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