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PTGFRN Gene

protein-coding   GIFtS: 60
GCID: GC01P117452

Prostaglandin F2 Receptor Inhibitor

(Previous name: prostaglandin F2 receptor negative regulator)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin F2 Receptor Inhibitor1 2     CD9 Partner 12 3
FPRP2 3 5     CD3152
Prostaglandin F2 Receptor Negative Regulator1 2     SMAP-62
Glu-Trp-Ile EWI Motif-Containing Protein F2 3     CD9P13
Prostaglandin F2-Alpha Receptor Regulatory Protein2 3     EWIF3
Prostaglandin F2-Alpha Receptor-Associated Protein2 3     KIAA14363
CD9P-12 3     CD315 Antigen3
EWI-F2 3     

External Ids:    HGNC: 96011   Entrez Gene: 57382   Ensembl: ENSG000001342477   OMIM: 6012045   UniProtKB: Q9P2B23   

Export aliases for PTGFRN gene to outside databases

Previous GC identifers: GC01P117943 GC01P116322 GC01P116600 GC01P116796 GC01P116799 GC01P117164 GC01P117254 GC01P115311


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PTGFRN Gene:
PTGFRN (prostaglandin F2 receptor inhibitor) is a protein-coding gene. An important paralog of this gene is IGSF8.

UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
receptor seems to occur (By similarity)

Gene Wiki entry for PTGFRN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGFRN gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   GATA-1   RORalpha1   S8   E2F   E2F-1   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGFRN promoter sequence
   Search Chromatin IP Primers for PTGFRN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGFRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

PTGFRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGFRN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117452:  view genomic region     (about GC identifiers)

Start:
117,452,679 bp from pter      End:
117,532,980 bp from pter
Size:
80,302 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2 (See protein sequence)
Recommended Name: Prostaglandin F2 receptor negative regulator precursor  
Size: 879 amino acids; 98556 Da
Subunit: Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151
Sequence caution: Sequence=BAA92674.1; Type=Erroneous initiation; Sequence=BAC11104.1; Type=Erroneous termination;
Positions=864; Note=Translated as Gln;
Secondary accessions: Q5VVU9 Q8N2K6

Explore the universe of human proteins at neXtProt for PTGFRN: NX_Q9P2B2

Explore proteomics data for PTGFRN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn44, Ser150, Asn286, Asn300, Asn383, Asn413, Asn525, Asn600, Asn618, Asn691
  • Modification sites at PhosphoSitePlus

  • See PTGFRN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065173.2  
    ENSEMBL proteins: 
     ENSP00000376899  

    PTGFRN Human Recombinant Protein Products:

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    Novus Biologicals PTGFRN Protein
    Sino Biological Recombinant Protein for PTGFRN
    Sino Biological Cell Lysate for PTGFRN
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGFRN

     
    Search eBioscience for Proteins for PTGFRN 

    PTGFRN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGFRN
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    PTGFRN Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTGFRN
    Cloud-Clone Corp. CLIAs for PTGFRN
    Search eBioscience for ELISAs for PTGFRN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9P2B2

    ProtoNet protein and cluster: Q9P2B2

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: FPRP_HUMAN, Q9P2B2
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with PTGFRN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FPRP_HUMAN, Q9P2B2
    Function: Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing
    the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha
    receptor seems to occur (By similarity)

         Genatlas biochemistry entry for PTGFRN:
    prostaglandin F2 alpha receptor (FP),negative receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11278880
         
    Find genes that share ontologies with PTGFRN           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ptgfrn):
     behavior/neurological 

    Find genes that share phenotypes with PTGFRN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTGFRN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGFRN
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    miRNA
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    miRTarBase miRNAs that target PTGFRN:
    hsa-let-7b-5p (MIRT051989), hsa-mir-92a-3p (MIRT049140), hsa-mir-24-3p (MIRT030461), hsa-mir-18a-3p (MIRT040958), hsa-mir-615-3p (MIRT040204), hsa-mir-877-5p (MIRT037210), hsa-mir-30a-5p (MIRT005149)

    Block miRNA regulation of human, mouse, rat PTGFRN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidPTGFRN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTGFRN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PTGFRN (NM_020440)
    Sino Biological Human cDNA Clone for PTGFRN
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FPRP_HUMAN, Q9P2B2: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Golgi
    apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    plasma membrane3
    extracellular2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PTGFRN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTGFRN
    Interactions:

        GeneGlobe Interaction Network for PTGFRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PTGFRN (Q9P2B22, 3 ENSP000003768994) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD81P600332, 3, ENSP000002636454MINT-8407185 I2D: score=2 STRING: ENSP00000263645
    CD9P219262, 3, ENSP000000091804MINT-8407185 I2D: score=2 STRING: ENSP00000009180
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=2 STRING: ENSP00000257857
    CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
    CD82P277013, ENSP000002271554I2D: score=2 STRING: ENSP00000227155
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034389lipid particle organization IEA--

    Find genes that share ontologies with PTGFRN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTGFRN (FPRP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTGFRN gene: 
    NM_020440.2  

    Unigene Cluster for PTGFRN:

    Prostaglandin F2 receptor inhibitor
    Hs.418093  [show with all ESTs]
    Unigene Representative Sequence: BC152454
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393203(uc001egv.1) ENST00000496699 ENST00000497385
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PTGFRN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PTGFRN (see all 100):
    hsa-miR-548j hsa-miR-607 hsa-miR-146a hsa-miR-106a hsa-miR-1224-3p hsa-miR-128 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidPTGFRN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PTGFRN
    Predesigned siRNA for gene silencing in human, mouse, rat PTGFRN
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGFRN (NM_020440)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGFRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGFRN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PTGFRN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTGFRN
      QuantiTect SYBR Green Assays in human, mouse, rat PTGFRN
      QuantiFast Probe-based Assays in human, mouse, rat PTGFRN

    Additional mRNA sequence: 

    AB014734.1 AB037857.1 AK001863.1 AK024785.1 AK074637.1 BC022235.1 BC042164.1 BC098142.1 
    BC114520.1 BC139718.1 BC152454.1 

    13 DOTS entries:

    DT.117499  DT.95085973  DT.100786281  DT.95153899  DT.100786280  DT.121432910  DT.121632648  DT.100786278 
    DT.121432942  DT.121608331  DT.91737304  DT.91756882  DT.91756884 

    517 AceView cDNA sequences (see top 24):

    BC063317 AA931766 W58002 W56614 CD679141 BE857712 CA314891 W57857 
    AI656398 AW808040 AA569727 AI262297 AI090820 AA036803 AI367905 AB014734 
    NM_020440 AW627596 AA433926 AI365353 AA826257 AW808004 AI417101 AW808052 
    AI636636 AW807998 AW807990 AW808012 CB241375 AL135637 BQ640041 BM999645 
    AI474355 AI079502 AW808162 AW276593 AW808191 AB037857 AI972169 BE551564 
    AW808023 AI419674 AW808009 BF063322 AI829647 AW808048 AW808001 CB306568 
    BC022235 BE857128 BF222064 AI334010 AA631315 AA991901 AI086286 AA576818 
    BF205212 AI591362 AW808014 AI656409 T49390 BM692433 AW808102 AW808070 
    AA587900 BX504980 CD657195 AW808113 AW807993 AW808203 N32364 AA478705 
    AW808106 AW808074 AA733069 AW808041 AW808137 AI049790 AW808111 AW808195 
    AW808104 AW808110 AW808049 BM990205 AW808201 CA424158 AA337498 AI342575 
    AW808129 AW808192 CA448681 AI744142 AW808193 AA527866 AW807991 AW808017 
    BF342215 BG742994 AA427887 AK001863 AJ709972 AW808073 AW808035 AW808177 
    AW808131 CA447304 BM794172 AI339563 BG680204 AW808108 AW808020 BM786196 
    CF139708 BU753136 AW808161 BF476250 CB051980 AI289773 AI346360 CF265176 
    AW136055 AI694579 AA577019 AW807996 AW808036 CD679516 CB126045 N29261 
    AW808202 AW808007 AW808008 BQ362684 BQ023279 AI657082 W81707 BG056279 
    W81243 BF032559 AA860279 AW808135 AW808010 AW808109 AA045156 AW808000 
    CB265454 AK074637 CA428896 AA131258 BM664025 AW808002 AW808005 AA579572 
    AW808066 BM126936 Z42502 AW150211 AA430582 BQ015227 AU135751 AW808141 
    CA445365 AI421845 AK024785 AW808127 AI953818 BQ024934 AI160499 AW808182 
    AW808029 AW808046 AI582364 CA443926 N63283 AA527437 BG681929 CA414342 
    AA427970 AW808064 AA928515 AJ707126 AW952618 BE747016 CB960904 BX472912 
    AI160497 AW808194 W33022 Z38697 AA578532 W56644 AI813323 N20548 
    AW138104 BF108807 R71365 AA972908 BG762047 AW808026 AW808011 AW808185 
    AW808138 CB989776 AW807997 BX484024 AI004738 AW808107 BC042164 AW808037 
    CD102506 AA045111 AW808058 AW808055 AI174534 AW808209 AA456344 AW808163 
    AW808173 AW808315 AW808142 AW808335 H39788 AW808039 AW808174 AW807970 
    AW808175 BI259300 AW808056 CB989984 AW808299 AW808231 BF109637 AW808153 
    R71366 AV647561 AA779619 AW808165 AW807994 AW808121 R38331 AW808069 
    AW808038 AW808059 AW808071 AW808080 AW808128 AW808100 AW008770 W33023 
    AW808198 AW028975 AW808239 CB134805 AW808224 AW808031 AW808210 H52228 
    AW808227 AW808208 AW808178 AW808120 AW808065 AW808169 BG926162 AW808147 
    AW807992 AI832307 AW590534 H39629 AA953913 AW808189 AW808259 AW808025 
    AI970282 AW808196 AA380041 AW808184 AI651480 AW808117 AW808047 R39414 
    AW808279 AW807980 AW808019 CK818740 BE763981 AW808068 AW808072 AW808154 
    BQ362676 AW807974 AW808057 AW808112 BE858153 AA994540 BG167981 CB158037 
    AW808180 AW808176 AW807968 AW613176 AW808313 AW807978 AA101988 AW808285 
    AW808212 BQ362759 AW808013 AW808164 AW808190 AW629585 R50483 BQ187980 
    BQ363027 N23384 AW808187 BQ362758 AU156253 BM752150 D79826 AW808321 
    AW807972 AV687966 AW808245 T78348 AW808149 AW364806 AJ709983 H94529 
    R48561 AW808197 W20412 AW808340 BG680733 AL527521 AW808237 AW808263 
    AW808060 AW808160 AW808082 AW808200 AW808199 AW808103 BQ362680 AW808088 
    AW364807 AW808099 BQ363028 AI952215 AW808277 AW083749 AW808090 AA334316 
    AW808339 AW808303 BQ362682 BG896461 AW808304 AA099551 BQ311905 AW808264 
    AW808170 AW808229 AW808155 AW808116 AW808322 AW808312 AW808300 AW808276 
    AW808181 AW808168 AW364809 BF588488 AW808140 AW808145 AW808324 AW808317 
    R42921 AW808061 AW808134 AW808270 BQ362448 R14224 BE763971 R48657 
    AW808093 AW808151 AW808260 AW808275 AW808336 AW808236 R40643 AW808281 
    AW808207 H11657 AW807999 AW808288 AW808050 AW808214 BF947446 AW808205 
    BQ362683 AW808248 N83258 AW808215 AW808034 AW808286 AW808114 AW808269 
    AW808311 R63083 AW808097 AW808246 AW808241 AW808150 R69994 BX486309 
    AW808083 AW807979 AW808094 N89036 AW808235 AW808119 AW808250 AW808101 
    AW808331 AW807995 BQ363235 AW808087 BQ363051 AW808228 BF435727 AW808092 
    AW808211 BI460322 AW608541 AW808133 AW808290 AW808247 AW808084 R69995 
    R63127 BE503768 BQ362681 AW808326 AW808032 AW808188 AW808030 AW808295 
    AW808015 BE926021 BQ363150 BF735440 AW808144 AW808287 AW808085 AW808255 
    AW808323 T49389 AW807973 BQ362757 AW808225 AW808062 AW808251 AW808157 
    AW808132 AW808328 BQ362677 AW808327 AW808171 AW808292 AW808291 AW808006 
    AW808256 AW808206 AW808044 AW808204 H12186 CB050496 BF735231 AW808159 
    BQ314837 AW807975 AW808095 AW808332 AW808319 AW808252 AW952538 AW808283 
    AW808296 AW808243 R50571 AL527520 BQ363152 AW808334 AW808226 AW807963 
    AW808244 AW808139 AW807971 AW808320 BQ363053 AW937185 BF752970 AW808298 
    R17584 AW808183 BG827669 AW808284 AW808258 AW808018 BQ363237 H52319 
    BF832750 AW381625 BG978079 AW808045 BF154659 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTGFRN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTCAC
    PTGFRN Expression
    About this image


    PTGFRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Stomach (Gastrointestinal Tract)
    PTGFRN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTGFRN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.418093
        Custom PCR Arrays for PTGFRN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PTGFRN
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGFRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PTGFRN gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgfrn1 , 5 prostaglandin F2 receptor negative regulator1, 5 86.35(n)1
    89.99(a)1
      3 (43.93 cM)5
    192211  NM_011197.31  NP_035327.21 
     1010402325 
    chicken
    (Gallus gallus)
    Aves PTGFRN1 prostaglandin F2 receptor negative regulator 66.74(n)
    64.77(a)
      418449  XM_416660.4  XP_416660.4 
    lizard
    (Anolis carolinensis)
    Reptilia PTGFRN6
    prostaglandin F2 receptor inhibitor
    62(a)
    1 ↔ 1
    3(162969244-163051159)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004932521 prostaglandin F2 receptor negative regulator-like 53.7(n)
    43.46(a)
      100493252  XM_002943835.2  XP_002943881.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-132g1.71 si:ch211-132g1.7 48.39(n)
    35.91(a)
      101884699  XM_005168313.1  XP_005168370.1 


    ENSEMBL Gene Tree for PTGFRN (if available)
    TreeFam Gene Tree for PTGFRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTGFRN gene
    IGSF82  IGSF32  CD1012  
    1 SIMAP similar gene for PTGFRN using alignment to 4 protein entries:     FPRP_HUMAN (see all proteins):
    smap-6

    Find genes that share paralogs with PTGFRN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTGFRN (see all 1586)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478994901,2
    --115309318(+) TAGTGA/TATACA 1 -- us2k10--------
    rs1818678531,2
    --115309378(+) TAAGCA/GTTCTG 1 -- us2k10--------
    rs1405140131,2
    --115309382(+) CGTTCA/TGGGTG 1 -- us2k10--------
    rs1868682141,2
    --117450704(+) CCTGCA/GAGATT 1 -- us2k10--------
    rs1913595111,2
    --117450857(+) AAATTC/TTTTTT 1 -- us2k10--------
    rs2008932111,2
    --117450930(+) AAAAA-/GAAAGA 1 -- us2k10--------
    rs1504350901,2
    --117450951(+) AGAAGA/GAAAAG 1 -- us2k10--------
    rs24787651,2
    C--117451033(+) AGGAGC/TTCGAG 1 -- us2k18Minor allele frequency- T:0.31WA NA CSA EA 365
    rs1832297751,2
    --117451321(+) CCCCCA/GCCTCC 1 -- us2k10--------
    rs1853437271,2
    --117451330(+) CCCCCG/TGCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTGFRN (117452679 - 117532980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PTGFRN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519074CNV Loss19592680
    nsv2566CNV Loss18451855
    nsv831159CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGFRN
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGFRN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601204    OMIM disorders: --


    Find genes that share disorders with PTGFRN           About GenesLikeMe

    1 Novoseek inferred disease relationship for PTGFRN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 17498801 (1)

    Genetic Association Database (GAD): PTGFRN
    Human Genome Epidemiology (HuGE) Navigator: PTGFRN (1 document)

    Export disorders for PTGFRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTGFRN gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with PTGFRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glycosylation status of the membrane protein CD9P-1. (PubMed id 17960739)1, 2, 9 Andre M.... Le Naour F. (Proteomics 2007)
    2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PubMed id 11278880)1, 2, 9 Charrin S.... Rubinstein E. (J. Biol. Chem. 2001)
    3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (Biol. Psychiatry 2010)
    4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. (PubMed id 8655148)1, 3 Orlicky D.J....Sikela J.M. (Hum. Genet. 1996)
    8. FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. (PubMed id 11087758)1, 9 Stipp C.S....Hemler M.E. (J. Biol. Chem. 2001)
    9. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PubMed id 17407154)1, 9 Abache T....Rubinstein E. (J. Cell. Biochem. 2007)
    10. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PubMed id 16690612)1, 9 Sala-ValdAcs M....YA!A+ez-MA^ M. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5738 HGNC: 9601 AceView: PTGFRN Ensembl:ENSG00000134247 euGenes: HUgn5738
    ECgene: PTGFRN H-InvDB: PTGFRN

    (According to HUGE)
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    HUGE: KIAA1436

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTGFRN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTGFRN gene:
    Search GeneIP for patents involving PTGFRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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