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Aliases for PTGFR Gene

Aliases for PTGFR Gene

  • Prostaglandin F Receptor 2 3
  • Prostaglandin F Receptor (FP) 2 3 5
  • Prostanoid FP Receptor 3 4
  • PGF2-Alpha Receptor 3 4
  • PGF Receptor 3 4
  • Prostaglandin Receptor (2-Alpha) 3
  • Prostaglandin F2 Alpha Receptor 3
  • PGF2 Alpha Receptor 3
  • FP 3

External Ids for PTGFR Gene

Previous GeneCards Identifiers for PTGFR Gene

  • GC01P079117
  • GC01P077856
  • GC01P078347
  • GC01P078668
  • GC01P078542
  • GC01P078729
  • GC01P077088

Summaries for PTGFR Gene

Entrez Gene Summary for PTGFR Gene

  • The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGFR Gene

PTGFR (Prostaglandin F Receptor) is a Protein Coding gene. Diseases associated with PTGFR include ocular hypertension and borderline glaucoma. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGFR Gene

  • Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Tocris Summary for PTGFR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGFR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGFR Gene

Genomics for PTGFR Gene

Regulatory Elements for PTGFR Gene

Genomic Location for PTGFR Gene

Chromosome:
1
Start:
78,303,884 bp from pter
End:
78,540,701 bp from pter
Size:
236,818 bases
Orientation:
Plus strand

Genomic View for PTGFR Gene

Genes around PTGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGFR Gene

Proteins for PTGFR Gene

  • Protein details for PTGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43088-PF2R_HUMAN
    Recommended name:
    Prostaglandin F2-alpha receptor
    Protein Accession:
    P43088
    Secondary Accessions:
    • A8K9Y0
    • Q2KHP3
    • Q6RYQ6
    • Q9P1X4

    Protein attributes for PTGFR Gene

    Size:
    359 amino acids
    Molecular mass:
    40055 Da
    Quaternary structure:
    • Isoform 1 can form heterodimers with isoform 5 (and probably other isoforms).

    Alternative splice isoforms for PTGFR Gene

neXtProt entry for PTGFR Gene

Proteomics data for PTGFR Gene at MOPED

Post-translational modifications for PTGFR Gene

  • Glycosylation at Asn 4 and Asn 19
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGFR Gene

Antibody Products

No data available for DME Specific Peptides for PTGFR Gene

Domains & Families for PTGFR Gene

Gene Families for PTGFR Gene

Protein Domains for PTGFR Gene

Suggested Antigen Peptide Sequences for PTGFR Gene

Graphical View of Domain Structure for InterPro Entry

P43088

UniProtKB/Swiss-Prot:

PF2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGFR: view

Function for PTGFR Gene

Molecular function for PTGFR Gene

GENATLAS Biochemistry:
prostaglandin F2 alpha receptor,subtype FP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
genes like me logo Genes that share phenotypes with PTGFR: view

Animal Models for PTGFR Gene

MGI Knock Outs for PTGFR:

Animal Model Products

miRNA for PTGFR Gene

miRTarBase miRNAs that target PTGFR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGFR Gene

Localization for PTGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGFR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGFR Gene COMPARTMENTS Subcellular localization image for PTGFR gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18508192
genes like me logo Genes that share ontologies with PTGFR: view

Pathways & Interactions for PTGFR Gene

genes like me logo Genes that share pathways with PTGFR: view

Gene Ontology (GO) - Biological Process for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007567 parturition TAS 9918852
GO:0010628 positive regulation of gene expression IEA --
GO:0032355 response to estradiol IEA --
genes like me logo Genes that share ontologies with PTGFR: view

No data available for SIGNOR curated interactions for PTGFR Gene

Drugs & Compounds for PTGFR Gene

(35) Drugs for PTGFR Gene - From: DGIdb, IUPHAR, Tocris, Novoseek, ApexBio, HMDB, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 129
Latanoprost Approved, Investigational Pharma agonist, Target 184
Travoprost Approved Pharma agonist, Target 127
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 74
Dinoprost Tromethamine Approved Pharma Target, agonist 11

(20) Additional Compounds for PTGFR Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]PGF<sub>2alpha</sub>
Full agonist, Agonist
13,14-dihydro-16-<i>m</i>-chlorophenoxy-<i>w</i>-tetranor-PGF<sub>1alpha</sub>
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
Tafluprost free acid
(+-)-Cloprostenol sodium salt
55028-72-3
genes like me logo Genes that share compounds with PTGFR: view

Drug Products

Transcripts for PTGFR Gene

Unigene Clusters for PTGFR Gene

Prostaglandin F receptor (FP):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGFR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for PTGFR Gene

GeneLoc Exon Structure for
PTGFR
ECgene alternative splicing isoforms for
PTGFR

Expression for PTGFR Gene

mRNA expression in normal human tissues for PTGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGFR Gene

This gene is overexpressed in Nerve - Tibial (x7.1).

Protein differential expression in normal tissues from HIPED for PTGFR Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGFR Gene



SOURCE GeneReport for Unigene cluster for PTGFR Gene Hs.654365

mRNA Expression by UniProt/SwissProt for PTGFR Gene

P43088-PF2R_HUMAN
Tissue specificity: Eye.
genes like me logo Genes that share expression patterns with PTGFR: view

Protein tissue co-expression partners for PTGFR Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PTGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGFR 35
  • 99.72 (n)
  • 99.72 (a)
PTGFR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FP 36
  • 82 (a)
OneToOne
PTGFR 35
  • 86.85 (n)
  • 83.1 (a)
dog
(Canis familiaris)
Mammalia PTGFR 35
  • 92.02 (n)
  • 94.37 (a)
PTGFR 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgfr 16
Ptgfr 36
  • 87 (a)
OneToOne
Ptgfr 35
  • 85.25 (n)
  • 89.08 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PTGFR 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgfr 35
  • 81.6 (n)
  • 87.61 (a)
chicken
(Gallus gallus)
Aves PTGFR 35
  • 79.26 (n)
  • 82.95 (a)
PTGFR 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGFR 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgfr 35
  • 71.35 (n)
  • 71.63 (a)
zebrafish
(Danio rerio)
Actinopterygii ptgfr 36
  • 46 (a)
OneToMany
PTGFR (2 of 2) 36
  • 48 (a)
OneToMany
ptgfr 35
  • 56.34 (n)
  • 54.68 (a)
Species with no ortholog for PTGFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGFR Gene

ENSEMBL:
Gene Tree for PTGFR (if available)
TreeFam:
Gene Tree for PTGFR (if available)

Paralogs for PTGFR Gene

Paralogs for PTGFR Gene

(7) SIMAP similar genes for PTGFR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTGFR: view

Variants for PTGFR Gene

Sequence variations from dbSNP and Humsavar for PTGFR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs540757 -- 78,521,269(+) CTAAA(A/G)TTTAC intron-variant
rs473027 -- 78,526,517(+) TCCTA(A/G)ATCTT intron-variant
rs520171 -- 78,524,165(+) TGTTC(A/C)AGGGT intron-variant
rs552177 -- 78,525,321(+) attca(C/G)gtttc intron-variant
rs552328 -- 78,525,378(+) ctcag(A/G)aaagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGFR Gene

Variant ID Type Subtype PubMed ID
nsv871835 CNV Gain 21882294
nsv870807 CNV Loss 21882294
nsv1566 CNV Insertion 18451855
nsv871260 CNV Gain 21882294
esv2660451 CNV Deletion 23128226
nsv871959 CNV Gain 21882294
nsv870919 CNV Loss 21882294
esv2750185 CNV Deletion 23290073
esv2376136 CNV Deletion 18987734
esv2750196 CNV Deletion 23290073
esv1614956 CNV Deletion 17803354

Variation tolerance for PTGFR Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGFR Gene

HapMap Linkage Disequilibrium report
PTGFR
Human Gene Mutation Database (HGMD)
PTGFR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFR Gene

Disorders for PTGFR Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTGFR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ocular hypertension
borderline glaucoma
  • preglaucoma
endometrial adenocarcinoma
  • adenocarcinoma of endometrium
iridocyclitis
  • primary iridocyclitis
open-angle glaucoma
  • glaucoma simplex
- elite association - COSMIC cancer census association via MalaCards
Search PTGFR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTGFR

Genetic Association Database (GAD)
PTGFR
Human Genome Epidemiology (HuGE) Navigator
PTGFR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGFR
genes like me logo Genes that share disorders with PTGFR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGFR Gene

Publications for PTGFR Gene

  1. Cloning and expression of a cDNA for the human prostanoid FP receptor. (PMID: 8300593) Abramovitz M. … Grygorczyk R. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. (PMID: 12204699) Maxey K.M. … LaBrecque J. (Surv Ophthalmol 2002) 23 25 26
  3. Effect of latanoprost on the extracellular matrix of the ciliary muscle. A study on cultured cells and tissue sections. (PMID: 9733584) Ocklind A. (Exp. Eye Res. 1998) 23 25 26
  4. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 3 23
  5. Prostaglandin F2 alpha receptor. (PMID: 8777582) Sakamoto K. … Ito S. (J Lipid Mediat Cell Signal 1995) 23 25 26

Products for PTGFR Gene

Sources for PTGFR Gene

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