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Aliases for PTGFR Gene

Aliases for PTGFR Gene

  • Prostaglandin F Receptor 2 3 5
  • FP Prostanoid Receptor 2 3
  • Prostanoid FP Receptor 3 4
  • PGF Receptor 3 4
  • Prostaglandin Receptor (2-Alpha) 3
  • Prostaglandin F2-Alpha Receptor 3
  • Prostaglandin F Receptor (FP) 2
  • PGF2 Alpha Receptor 3
  • PGF2-Alpha Receptor 4
  • FP 3

External Ids for PTGFR Gene

Previous GeneCards Identifiers for PTGFR Gene

  • GC01P079117
  • GC01P077856
  • GC01P078347
  • GC01P078668
  • GC01P078542
  • GC01P078729
  • GC01P077088

Summaries for PTGFR Gene

Entrez Gene Summary for PTGFR Gene

  • The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGFR Gene

PTGFR (Prostaglandin F Receptor) is a Protein Coding gene. Diseases associated with PTGFR include Ocular Hypertension and Endometrial Adenocarcinoma. Among its related pathways are Calcium signaling pathway and Eicosanoid ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot for PTGFR Gene

  • Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Tocris Summary for PTGFR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGFR Gene

Additional gene information for PTGFR Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGFR Gene

Genomics for PTGFR Gene

Regulatory Elements for PTGFR Gene

Enhancers for PTGFR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H078276 0.6 ENCODE 15.5 -26.4 -26441 1 JUND BCL11A CBFB JUNB RUNX3 BATF PTGFR FUBP1 PIR53489
GH01H078303 0.6 ENCODE 13.4 +0.1 84 0 JUN CEBPB EP300 RAD21 RFX5 JUND SMC3 STAT3 FOS PTGFR ENSG00000227556
GH01H078286 0.5 ENCODE 14.5 -16.9 -16943 1 POLR2A JUN STAT3 CEBPB EP300 PTGFR PIR53489
GH01H078291 0.5 ENCODE 13.7 -11.3 -11268 1 ZNF316 RCOR1 MAFK PTGFR PIR53489
GH01H078278 0.5 ENCODE 13.6 -24.6 -24571 1 JUND CEBPB FOS PTGFR PIR53489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTGFR on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGFR Gene

Chromosome:
1
Start:
78,303,884 bp from pter
End:
78,540,701 bp from pter
Size:
236,818 bases
Orientation:
Plus strand

Genomic View for PTGFR Gene

Genes around PTGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGFR Gene

Proteins for PTGFR Gene

  • Protein details for PTGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43088-PF2R_HUMAN
    Recommended name:
    Prostaglandin F2-alpha receptor
    Protein Accession:
    P43088
    Secondary Accessions:
    • A8K9Y0
    • Q2KHP3
    • Q6RYQ6
    • Q9P1X4

    Protein attributes for PTGFR Gene

    Size:
    359 amino acids
    Molecular mass:
    40055 Da
    Quaternary structure:
    • Isoform 1 can form heterodimers with isoform 5 (and probably other isoforms).

    Alternative splice isoforms for PTGFR Gene

neXtProt entry for PTGFR Gene

Post-translational modifications for PTGFR Gene

  • Glycosylation at Asn4 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGFR Gene

No data available for DME Specific Peptides for PTGFR Gene

Domains & Families for PTGFR Gene

Gene Families for PTGFR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PTGFR Gene

Graphical View of Domain Structure for InterPro Entry

P43088

UniProtKB/Swiss-Prot:

PF2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGFR: view

Function for PTGFR Gene

Molecular function for PTGFR Gene

GENATLAS Biochemistry:
prostaglandin F2 alpha receptor,subtype FP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Phenotypes From GWAS Catalog for PTGFR Gene

Gene Ontology (GO) - Molecular Function for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004958 prostaglandin F receptor activity IDA,TAS 18587449
genes like me logo Genes that share ontologies with PTGFR: view
genes like me logo Genes that share phenotypes with PTGFR: view

Animal Models for PTGFR Gene

MGI Knock Outs for PTGFR:

Animal Model Products

CRISPR Products

miRNA for PTGFR Gene

miRTarBase miRNAs that target PTGFR

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGFR
  • Applied Biological Materials Clones for PTGFR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGFR Gene

Localization for PTGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGFR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGFR gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 10575000
GO:0005737 cytoplasm IDA 18508192
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8300593
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTGFR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGFR Gene

Pathways & Interactions for PTGFR Gene

genes like me logo Genes that share pathways with PTGFR: view

Gene Ontology (GO) - Biological Process for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007567 parturition TAS 9918852
GO:0008284 positive regulation of cell proliferation IMP 18508192
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with PTGFR: view

No data available for SIGNOR curated interactions for PTGFR Gene

Drugs & Compounds for PTGFR Gene

(37) Drugs for PTGFR Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 135
Latanoprost Approved, Investigational Pharma agonist, Target 203
Travoprost Approved Pharma agonist, Target 132
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 80
Dinoprost Tromethamine Approved, Vet_approved Pharma Target, agonist 11

(18) Additional Compounds for PTGFR Gene - From: HMDB, Novoseek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]PGF<sub>2alpha</sub>
Full agonist, Agonist
13,14-dihydro-16-<i>m</i>-chlorophenoxy-<i>w</i>-tetranor-PGF<sub>1alpha</sub>
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
Tafluprost free acid

(5) Tocris Compounds for PTGFR Gene

Compound Action Cas Number
Alprostadil Prostaglandin. Vasodilator and antiplatelet agent in vivo 745-65-3
Iloprost Prostacyclin (PGI2) analog 78919-13-8
L-798,106 Potent and highly selective EP3 antagonist 244101-02-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(3) ApexBio Compounds for PTGFR Gene

Compound Action Cas Number
AL 8810 Antagonist of prostaglandin F2α (FP) receptor. 246246-19-5
Alprostadil 745-65-3
Bimatoprost 155206-00-1
genes like me logo Genes that share compounds with PTGFR: view

Drug Products

Transcripts for PTGFR Gene

Unigene Clusters for PTGFR Gene

Prostaglandin F receptor (FP):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGFR
  • Applied Biological Materials Clones for PTGFR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PTGFR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for PTGFR Gene

GeneLoc Exon Structure for
PTGFR
ECgene alternative splicing isoforms for
PTGFR

Expression for PTGFR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGFR Gene

This gene is overexpressed in Nerve - Tibial (x7.1).

Protein differential expression in normal tissues from HIPED for PTGFR Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGFR Gene



Protein tissue co-expression partners for PTGFR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGFR Gene:

PTGFR

SOURCE GeneReport for Unigene cluster for PTGFR Gene:

Hs.654365

mRNA Expression by UniProt/SwissProt for PTGFR Gene:

P43088-PF2R_HUMAN
Tissue specificity: Eye.

Evidence on tissue expression from TISSUES for PTGFR Gene

  • Eye(4.2)
  • Liver(4)
genes like me logo Genes that share expression patterns with PTGFR: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGFR Gene

Orthologs for PTGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGFR 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia PTGFR 33 34
  • 92.02 (n)
cow
(Bos Taurus)
Mammalia PTGFR 33
  • 86.85 (n)
FP 34
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgfr 33 16 34
  • 85.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTGFR 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgfr 33
  • 81.6 (n)
chicken
(Gallus gallus)
Aves PTGFR 33 34
  • 79.26 (n)
lizard
(Anolis carolinensis)
Reptilia PTGFR 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgfr 33
  • 71.35 (n)
zebrafish
(Danio rerio)
Actinopterygii ptgfr 33 34
  • 56.34 (n)
PTGFR (2 of 2) 34
  • 48 (a)
OneToMany
Species where no ortholog for PTGFR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGFR Gene

ENSEMBL:
Gene Tree for PTGFR (if available)
TreeFam:
Gene Tree for PTGFR (if available)

Paralogs for PTGFR Gene

Paralogs for PTGFR Gene

(7) SIMAP similar genes for PTGFR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTGFR: view

Variants for PTGFR Gene

Sequence variations from dbSNP and Humsavar for PTGFR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3753380 drug-response 78,490,747(-) GTTAG(A/G)CTGTC upstream-variant-2KB
rs1000012908 -- 78,540,292(+) CAGGG(G/T)GCAGC utr-variant-3-prime
rs1000016320 -- 78,495,615(+) AACTG(A/T)GGTAA intron-variant
rs1000017647 -- 78,499,835(+) TATTC(C/G)AAATG intron-variant
rs1000079200 -- 78,523,060(+) ACATC(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGFR Gene

Variant ID Type Subtype PubMed ID
esv1614956 CNV deletion 17803354
esv2376136 CNV deletion 18987734
esv2660451 CNV deletion 23128226
esv2750185 CNV deletion 23290073
esv2750196 CNV deletion 23290073
esv3586546 CNV loss 21293372
nsv1566 CNV insertion 18451855

Variation tolerance for PTGFR Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGFR Gene

Human Gene Mutation Database (HGMD)
PTGFR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGFR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFR Gene

Disorders for PTGFR Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTGFR Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ocular hypertension
endometrial adenocarcinoma
  • adenocarcinoma of endometrium
open-angle glaucoma
  • glaucoma simplex
glaucoma 1, open angle, e
  • primary open angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search PTGFR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTGFR

Genetic Association Database (GAD)
PTGFR
Human Genome Epidemiology (HuGE) Navigator
PTGFR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGFR
genes like me logo Genes that share disorders with PTGFR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGFR Gene

Publications for PTGFR Gene

  1. Cloning and expression of a cDNA for the human prostanoid FP receptor. (PMID: 8300593) Abramovitz M … Grygorczyk R (The Journal of biological chemistry 1994) 2 3 4 22 60
  2. Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes. (PMID: 18587449) Liang Y … Fliri H (British journal of pharmacology 2008) 3 4 22 60
  3. Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. (PMID: 14984197) Vielhauer GA … Regan JW (Archives of biochemistry and biophysics 2004) 3 4 22 60
  4. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. (PMID: 9341156) Kunapuli P … FitzGerald GA (The Journal of biological chemistry 1997) 3 4 22 60
  5. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 22 60

Products for PTGFR Gene

  • Addgene plasmids for PTGFR

Sources for PTGFR Gene

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