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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGES2 Gene

protein-coding   GIFtS: 66
GCID: GC09M130882

Prostaglandin E Synthase 2

(Previous name: chromosome 9 open reading frame 15)
(Previous symbol: C9orf15)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Prostaglandin E Synthase 21 2     GBF-12
C9orf151 2 3     Gamma-Interferon-Activated Transcriptional Element-Binding Factor 12
PGES22 3 5     GATE-Binding Factor 12
mPGES-22 3     Membrane-Associated Prostaglandin E Synthase 22
EC 5.3.99.33 8     Microsomal Prostaglandin E Synthase-22
GBF12 5     Microsomal Prostaglandin E Synthase 23
Chromosome 9 Open Reading Frame 151     

External Ids:    HGNC: 178221   Entrez Gene: 801422   Ensembl: ENSG000001483347   OMIM: 6081525   UniProtKB: Q9H7Z73   
ORGUL members:         
NONCODE14:n408035 n408034      

Export aliases for PTGES2 gene to outside databases

Previous GC identifers: GC09M121997 GC09M122529 GC09M124336 GC09M126259 GC09M127962 GC09M129922 GC09M100497


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGES2 Gene:
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion
of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated
by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for
this gene. (provided by RefSeq, Jun 2009)

GeneCards Summary for PTGES2 Gene: 
PTGES2 (prostaglandin E synthase 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PTGES2 include bladder transitional cell papilloma, and patent ductus arteriosus, and among its related super-pathways are Synthesis of Prostaglandins (PG) and Thromboxanes (TX) and Arachidonic acid metabolism. GO annotations related to this gene include prostaglandin-E synthase activity and electron carrier activity.

UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
Function: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the
more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG),
possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains
unclear

Gene Wiki entry for PTGES2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGES2 gene promoter:
         PPAR-gamma1   Tal-1   STAT3   PPAR-gamma2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGES2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGES2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGES2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.12

PTGES2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGES2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130882:  view genomic region     (about GC identifiers)

Start:
130,882,972 bp from pter      End:
130,890,741 bp from pter
Size:
7,770 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PTGES2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7 (See protein sequence)
Recommended Name: Prostaglandin E synthase 2  
Size: 377 amino acids; 41943 Da
Cofactor: Dihydrolipoic acid
Subunit: Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10
Subcellular location: Golgi apparatus membrane; Single-pass membrane protein
Subcellular location: Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthetized
as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The
truncated form is cytoplasmic and is enriched in the perinuclear region
Sequence caution: Sequence=CAI13822.1; Type=Erroneous gene model prediction;
Secondary accessions: Q53EW9 Q5SYV6 Q96GI0 Q96GL2

Explore the universe of human proteins at neXtProt for PTGES2: NX_Q9H7Z7

Explore proteomics data for PTGES2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H7Z7

  • 4 DME Specific Peptides for PTGES2 (Q9H7Z7)
     YRKVPIL  PNLADLAV  QLNDSSVIISALKTY  LTLYQYKTCPFCSKVRAFLD 

    PTGES2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGES2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243264.1  NP_079348.1  NP_945176.1  

    ENSEMBL proteins: 
     ENSP00000345341   ENSP00000411378   ENSP00000277462  

    Human Recombinant Protein Products for PTGES2: 
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    Novus Biologicals PTGES2 Lysates
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    ProSpec Recombinant Protein for PTGES2
    Cloud-Clone Corp. Proteins for PTGES2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol IEA--
    GO:0016021integral to membrane IEA--

    PTGES2 for ontologies           About GeneDecksing



    PTGES2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: mPGES2 
    Prostaglandin synthases

    5 InterPro protein domains:
     IPR002109 Glutaredoxin
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9H7Z7

    ProtoNet protein and cluster: Q9H7Z7

    1 Blocks protein domain: IPB002109 Glutaredoxin

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Similarity: Belongs to the GST superfamily
    Similarity: Contains 1 glutaredoxin domain
    Similarity: Contains 1 GST C-terminal domain


    PTGES2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGES2_HUMAN, Q9H7Z7
    Function: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the
    more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG),
    possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains
    unclear
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate

         Enzyme Number (IUBMB): EC 5.3.99.31 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0050220prostaglandin-E synthase activity IEA--
         
    PTGES2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTGES2:
     Lamellipodia cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ptges2):
     homeostasis/metabolism 

    PTGES2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptges2tm1Bhk for PTGES2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGES2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGES2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGES2 
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    miRNA
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    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidPTGES2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGES2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTGES2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    C20 prostanoid biosynthesis0.40
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    3PKA activation in glucagon signalling
    Neurophysiological process PGE2-induced pain processing0.44
    4Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    5Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PTGES2
        Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing


    2 GeneGo (Thomson Reuters) Pathways for PTGES2
        Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing

    3 BioSystems Pathways for PTGES2
        Eicosanoid Synthesis
    C20 prostanoid biosynthesis
    IFN-gamma pathway


    2         Kegg Pathways  (Kegg details for PTGES2):
        Arachidonic acid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Pathway: Lipid metabolism; prostaglandin biosynthesis


    PTGES2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGES2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/23 Interacting proteins for PTGES2 (Q9H7Z73 ENSP000003453414) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    EXOSC10Q017803, ENSP000003661354I2D: score=4 STRING: ENSP00000366135
    CEBPBP176763, ENSP000003054224I2D: score=1 STRING: ENSP00000305422
    PTGFRP430883, ENSP000003597934I2D: score=1 STRING: ENSP00000359793
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IEA--
    GO:0045454cell redox homeostasis IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IEA--
    GO:0046903secretion IEA--

    PTGES2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGES2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PTGES2 (PGES2)

    4 HMDB Compounds for PTGES2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PGH3prostaglandin H(,3) 42935-17-1--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    Prostaglandin H1PGH(,1) (see all 3)----
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--

    3 Novoseek inferred chemical compound relationships for PTGES2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin 75 7 19347995 (3), 17697149 (1)
    pge2 69.1 10 17707523 (2), 12835322 (1), 19347995 (1), 17566096 (1) (see all 8)
    arachidonic acid 47.6 1 15225371 (1)

    Search CenterWatch for drugs/clinical trials and news about PTGES2 / PGES2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTGES2 gene (5 alternative transcripts): 
    NM_001256335.1  NM_025072.6  NM_198938.2  NM_198939.1  NM_198940.1  

    Unigene Cluster for PTGES2:

    Prostaglandin E synthase 2
    Hs.495219  [show with all ESTs]
    Unigene Representative Sequence: NM_025072
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338961(uc004bti.3 uc004btl.3) ENST00000496594 ENST00000476655
    ENST00000493205 ENST00000487063 ENST00000474124 ENST00000449878 ENST00000476748
    ENST00000483625 ENST00000497109 ENST00000485510 ENST00000485237 ENST00000277462


    miRNA
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    Additional mRNA sequence: 

    AK024100.1 AK057049.1 AK223520.1 AK301618.1 BC009397.2 BC009456.1 BC011613.2 

    16 DOTS entries:

    DT.313899  DT.101982528  DT.100818961  DT.97761963  DT.92448074  DT.100818952  DT.100818947  DT.95169585 
    DT.100818953  DT.92448077  DT.92448086  DT.95169586  DT.95169588  DT.95169590  DT.100818957  DT.100832836 

    24/385 AceView cDNA sequences (see all 385):

    AA586777 BM848261 BX365139 BQ072118 BQ581757 BM920989 CR620072 W21593 
    AL578876 NM_198939 BQ639329 AI087053 BI333763 BQ949746 BG912203 BM773132 
    CR595131 BF342101 CR606648 CR616835 CR607888 BM737876 AA346389 BM923997 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PTGES2 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^
    SP1:                                                                                      -     -           -                                                   
    SP2:                                            -     -     -           -     -           -     -           -                                                   
    SP3:                    -     -     -     -     -     -     -                             -                 -                                                   
    SP4:                    -     -     -     -     -     -     -                             -     -           -                                                   
    SP5:                                                              -     -                 -     -           -                                                   

    ExUns: 10a · 10b · 10c ^ 11a · 11b
    SP1:  -                           
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PTGES2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGES2 expression in normal human tissues (normalized intensities)      PTGES2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGCATCT
    PTGES2 Expression
    About this image


    PTGES2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland ; glandular cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   

    See PTGES2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGES2

    SOURCE GeneReport for Unigene cluster: Hs.495219

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Tissue specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria
    and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain:
    cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and
    trachea, but not in the thymus or lung. Overexpressed in colorectal cancer

        SABiosciences Custom PCR Arrays for PTGES2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTGES2 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptges21 , 5 prostaglandin E synthase 21, 5 83.07(n)1
    83.51(a)1
      2 (22.09 cM)5
    969791  NM_133783.21  NP_598544.21 
     323958965 
    chicken
    (Gallus gallus)
    Aves PTGES21 prostaglandin E synthase 2 68.71(n)
    70.47(a)
      417214  XM_415498.3  XP_415498.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTGES26
    Uncharacterized protein
    72(a)
    1 ↔ 1
    AAWZ02041083(574-5809)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.249452 Xenopus laevis transcribed sequence with weak similarity more 76.11(n)    BU903846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565272 similar to prostaglandin E synthase 2 72.47(n)   393250  BC049325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(P)1 Suppressor of ref(2)P sterility 54.04(n)
    43.75(a)
      39856  NM_079392.3  NP_524116.2 
    worm
    (Caenorhabditis elegans)
    Secernentea R11A8.51 Protein R11A8.5 52.33(n)
    47.17(a)
      177925  NM_069512.3  NP_501913.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G421501 Glutathione S-transferase family protein 53.52(n)
    48.83(a)
      834220  NM_123580.1  NP_199030.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g02444001 hypothetical protein 53.52(n)
    51.61(a)
      4335293  NM_001058837.1  NP_001052302.1 


    ENSEMBL Gene Tree for PTGES2 (if available)
    TreeFam Gene Tree for PTGES2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 SNPs in PTGES2 are shown (see all 293)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs597699631,2
    C,F--100497152(+) TTGGTT/CCTGTC 3 -- ds50012Minor allele frequency- C:0.06CSA EA 122
    rs1891873191,2
    --100497186(+) CTGGTA/GCCCTG 3 -- ds50010--------
    rs1452489621,2
    C--100497187(+) TGGTGC/TCCTGG 3 -- ds50010--------
    rs1157646331,2
    F--100497197(+) GACCAG/AGTGAC 3 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1170848211,2
    F--100497298(+) CTGCAG/CAGCCC 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1491759271,2
    --100497308(+) CCACCA/GTGGGT 3 -- ds50010--------
    rs1432815801,2
    --100497373(+) CTGAGA/TGGTAT 3 -- ds50010--------
    rs1161933181,2
    F--100497379(+) GGTATC/ACTGGG 3 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1816055381,2
    C--100497417(+) CGTACC/TGTGCC 3 -- ds50010--------
    rs1467958121,2
    --100497502(+) GACCGC/GCAGCC 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for PTGES2 (130882972 - 130890741 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PTGES2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv8294n71CNV Loss21882294
    nsv893893CNV Loss21882294
    nsv6723CNV Loss18451855
    nsv893890CNV Loss21882294
    nsv818724CNV Loss17921354
    nsv893891CNV Loss21882294
    nsv893859CNV Loss21882294
    nsv893894CNV Gain21882294
    nsv471324CNV Gain18288195


    Human Gene Mutation Database (HGMD): PTGES2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608152    OMIM disorders: --

    14 diseases for PTGES2:    About MalaCards
    bladder transitional cell papilloma    patent ductus arteriosus    papilloma    skin cancer
    gingivitis    colorectal cancer    osteoarthritis    ovarian cancer
    colon cancer    adenoma    alzheimer's disease    hepatocellular carcinoma
    melanoma    gastric cancer


    PTGES2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for PTGES2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 18.6 1 12835322 (1)
    inflammation 12.2 1 12835322 (1)
    tumors 0 2 19347995 (2)

    Genetic Association Database (GAD): PTGES2
    Human Genome Epidemiology (HuGE) Navigator: PTGES2 (9 documents)

    Export disorders for PTGES2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGES2 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with PTGES2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel type of membrane- associated prostaglandin E synthase. (PubMed id 11866447)1, 2, 3 Tanikawa N.... Watanabe K. (2002)
    2. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. (PubMed id 12835322)1, 2, 9 Murakami M.... Kudo I. (2003)
    3. Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome. (PubMed id 17979097)1, 4, 9 Lindner I....Schrezenmeir J. (2007)
    4. Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. (PubMed id 17566096)1, 4, 9 Nitz I....Illig T. (2007)
    5. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. (PubMed id 12804604)1, 2, 9 Watanabe K....Ohmiya Y. (2003)
    6. Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort. (PubMed id 19371221)1, 4, 9 Fischer A....Illig T. (2009)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    8. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (2009)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    10. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. (PubMed id 17266179)1, 4 Fisher E....Doring F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80142 HGNC: 17822 AceView: PTGES2 Ensembl:ENSG00000148334 euGenes: HUgn80142
    ECgene: PTGES2 Kegg: 80142 H-InvDB: PTGES2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGES2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTGES2 gene:
    Search GeneIP for patents involving PTGES2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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