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Aliases for PTGES2 Gene

Aliases for PTGES2 Gene

  • Prostaglandin E Synthase 2 2 3 5
  • Prostaglandin-H(2) E-Isomerase 3 4
  • MPGE Synthase-2 3 4
  • EC 5.3.99.3 4 61
  • C9orf15 3 4
  • MPGES-2 3 4
  • PGES2 3 4
  • Gamma-Interferon-Activated Transcriptional Element-Binding Factor 1 3
  • Membrane-Associated Prostaglandin E Synthase 2 3
  • Membrane-Associated Prostaglandin E Synthase-2 4
  • Microsomal Prostaglandin E Synthase-2 3
  • Microsomal Prostaglandin E Synthase 2 4
  • Chromosome 9 Open Reading Frame 15 2
  • GATE-Binding Factor 1 3
  • GBF-1 3
  • GBF1 3

External Ids for PTGES2 Gene

Previous HGNC Symbols for PTGES2 Gene

  • C9orf15

Previous GeneCards Identifiers for PTGES2 Gene

  • GC09M121997
  • GC09M122529
  • GC09M124336
  • GC09M126259
  • GC09M127962
  • GC09M129922
  • GC09M130882
  • GC09M100497

Summaries for PTGES2 Gene

Entrez Gene Summary for PTGES2 Gene

  • The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

GeneCards Summary for PTGES2 Gene

PTGES2 (Prostaglandin E Synthase 2) is a Protein Coding gene. Diseases associated with PTGES2 include Urinary Tract Papillary Transitional Cell Benign Neoplasm and Bladder Papillary Transitional Cell Neoplasm. Among its related pathways are Ibuprofen Pathway, Pharmacodynamics and Innate Immune System. GO annotations related to this gene include heme binding and lyase activity.

UniProtKB/Swiss-Prot for PTGES2 Gene

  • Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

Gene Wiki entry for PTGES2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES2 Gene

Genomics for PTGES2 Gene

Regulatory Elements for PTGES2 Gene

Enhancers for PTGES2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G128097 1.6 Ensembl ENCODE dbSUPER 17 +27.6 27589 9.0 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NAIF1 PTGES2 CIZ1 PTGES2-AS1 SLC25A25-AS1 SLC25A25 LCN2 C9orf16 DNM1 ENSG00000230536
GH09G128090 1.3 ENCODE dbSUPER 12.5 +35.2 35225 5.3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A YY1 TCF12 GATA2 ELK1 SLC25A25-AS1 PTGES2 PTGES2-AS1 SLC25A25 NAIF1 ENSG00000230848 LCN2 C9orf16 CIZ1 ENSG00000230536
GH09G128096 0.7 ENCODE dbSUPER 12.5 +32.2 32220 0.0 BHLHE40 FOS SLC25A25-AS1 PTGES2-AS1 PTGES2 SLC25A25 NAIF1 LCN2 C9orf16 DNM1 CIZ1 ENSG00000230536
GH09G128049 1.4 Ensembl ENCODE dbSUPER 5.7 +77.0 77038 3.7 PKNOX1 ARID4B FEZF1 THRB ZSCAN9 ETV6 FOS RELB IKZF2 ZNF362 SLC25A25-AS1 PTGES2 ENSG00000230848 FAM102A
GH09G128143 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -16.5 -16463 2.9 HDAC1 FOXA2 TBL1XR1 SIN3A RAD21 TCF12 ZHX1 CEBPZ ZBTB11 ZNF623 ZNF79 CIZ1 C9orf16 PIP5KL1 PTGES2 SLC27A4 LCN2 PTGES2-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTGES2 on UCSC Golden Path with GeneCards custom track

Promoters for PTGES2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241818 662 2001 HDGF MLX ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for PTGES2 Gene

Chromosome:
9
Start:
128,120,693 bp from pter
End:
128,128,462 bp from pter
Size:
7,770 bases
Orientation:
Minus strand

Genomic View for PTGES2 Gene

Genes around PTGES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES2 Gene

Proteins for PTGES2 Gene

  • Protein details for PTGES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Z7-PGES2_HUMAN
    Recommended name:
    Prostaglandin E synthase 2
    Protein Accession:
    Q9H7Z7
    Secondary Accessions:
    • Q53EW9
    • Q5SYV6
    • Q96GI0
    • Q96GL2

    Protein attributes for PTGES2 Gene

    Size:
    377 amino acids
    Molecular mass:
    41943 Da
    Quaternary structure:
    • Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10.
    SequenceCaution:
    • Sequence=CAI13822.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PTGES2 Gene

Selected DME Specific Peptides for PTGES2 Gene

Q9H7Z7:
  • YRKVPIL
  • QLNDSSVIISALKTY
  • LTLYQYKTCPFCSKVRAFLD
  • PNLADLAV

Post-translational modifications for PTGES2 Gene

  • Ubiquitination at isoforms=141
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PTGES2 (Prostaglandin E Synthase 2/PTGES2)
  • Cloud-Clone Corp. Antibodies for PTGES2

Domains & Families for PTGES2 Gene

Gene Families for PTGES2 Gene

IUPHAR :

Suggested Antigen Peptide Sequences for PTGES2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7Z7

UniProtKB/Swiss-Prot:

PGES2_HUMAN :
  • Belongs to the GST superfamily.
Family:
  • Belongs to the GST superfamily.
genes like me logo Genes that share domains with PTGES2: view

Function for PTGES2 Gene

Molecular function for PTGES2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by dihydrolipoic acid, glutathione (GSH) and 2-mercaptoethanol.
UniProtKB/Swiss-Prot Function:
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

Enzyme Numbers (IUBMB) for PTGES2 Gene

Gene Ontology (GO) - Molecular Function for PTGES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0009055 electron carrier activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0016829 lyase activity ISS --
genes like me logo Genes that share ontologies with PTGES2: view
genes like me logo Genes that share phenotypes with PTGES2: view

Animal Models for PTGES2 Gene

MGI Knock Outs for PTGES2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGES2 Gene

Localization for PTGES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES2 Gene

Golgi apparatus membrane; Single-pass membrane protein.
Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. {ECO:0000269 PubMed:12835322}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGES2 gene
Compartment Confidence
mitochondrion 5
cytosol 5
extracellular 4
lysosome 4
golgi apparatus 4
peroxisome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PTGES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA,IDA 20833797
genes like me logo Genes that share ontologies with PTGES2: view

Pathways & Interactions for PTGES2 Gene

genes like me logo Genes that share pathways with PTGES2: view

Pathways by source for PTGES2 Gene

UniProtKB/Swiss-Prot Q9H7Z7-PGES2_HUMAN

  • Pathway: Lipid metabolism; prostaglandin biosynthesis.

Gene Ontology (GO) - Biological Process for PTGES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006693 prostaglandin metabolic process IEA --
genes like me logo Genes that share ontologies with PTGES2: view

No data available for SIGNOR curated interactions for PTGES2 Gene

Drugs & Compounds for PTGES2 Gene

(5) Drugs for PTGES2 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flurbiprofen Approved, Investigational Pharma Channel blocker 49
Suprofen Approved, Withdrawn Pharma 0
Mesalamine Pharma 164
Prostaglandin E2 Pharma activates the PGE2 receptor, Major endogenous prostanoid 0

(3) Additional Compounds for PTGES2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,13E)-(15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dienoate
42935-17-1

(3) ApexBio Compounds for PTGES2 Gene

Compound Action Cas Number
Flurbiprofen 5104-49-4
Mesalamine 89-57-6
Suprofen 40828-46-4
genes like me logo Genes that share compounds with PTGES2: view

Transcripts for PTGES2 Gene

Unigene Clusters for PTGES2 Gene

Prostaglandin E synthase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^
SP1: - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - -
SP8: - - -
SP9: - - - - - - -
SP10: -
SP11: - - -
SP12:
SP13: - - -
SP14:

ExUns: 10a · 10b · 10c ^ 11a · 11b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PTGES2 Gene

GeneLoc Exon Structure for
PTGES2
ECgene alternative splicing isoforms for
PTGES2

Expression for PTGES2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGES2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTGES2 Gene



Protein tissue co-expression partners for PTGES2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGES2 Gene:

PTGES2

SOURCE GeneReport for Unigene cluster for PTGES2 Gene:

Hs.495219

mRNA Expression by UniProt/SwissProt for PTGES2 Gene:

Q9H7Z7-PGES2_HUMAN
Tissue specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

Evidence on tissue expression from TISSUES for PTGES2 Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Liver(4.2)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with PTGES2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGES2 Gene

Orthologs for PTGES2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTGES2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGES2 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia PTGES2 34 35
  • 88.26 (n)
cow
(Bos Taurus)
Mammalia PTGES2 34 35
  • 86.9 (n)
mouse
(Mus musculus)
Mammalia Ptges2 34 16 35
  • 83.07 (n)
rat
(Rattus norvegicus)
Mammalia Ptges2 34
  • 83.07 (n)
oppossum
(Monodelphis domestica)
Mammalia PTGES2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGES2 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGES2 34 35
  • 71.7 (n)
lizard
(Anolis carolinensis)
Reptilia PTGES2 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptges2 34
  • 69.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24945 34
zebrafish
(Danio rerio)
Actinopterygii ptgesl 34 35
  • 63.36 (n)
zgc56527 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5924 34
fruit fly
(Drosophila melanogaster)
Insecta Su(P) 34 35
  • 54.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004992 34
  • 53.68 (n)
worm
(Caenorhabditis elegans)
Secernentea R11A8.5 34 35
  • 52.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42150 34
  • 54.91 (n)
rice
(Oryza sativa)
Liliopsida Os04g0244400 34
  • 56.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5225 35
  • 44 (a)
OneToOne
Species where no ortholog for PTGES2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTGES2 Gene

ENSEMBL:
Gene Tree for PTGES2 (if available)
TreeFam:
Gene Tree for PTGES2 (if available)

Paralogs for PTGES2 Gene

No data available for Paralogs for PTGES2 Gene

Variants for PTGES2 Gene

Sequence variations from dbSNP and Humsavar for PTGES2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000258062 -- 128,122,013(+) AGAAG(C/T)CTGGA intron-variant
rs1000262039 -- 128,125,481(+) GGCAC(C/T)CCCAG intron-variant
rs1000421357 -- 128,120,655(+) TCCCT(C/T)GACCG downstream-variant-500B, upstream-variant-2KB
rs1000515000 -- 128,129,091(+) TCTCC(C/T)AGCGC nc-transcript-variant, upstream-variant-2KB
rs1001042743 -- 128,126,970(+) GGCCA(A/G)GAGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTGES2 Gene

Variant ID Type Subtype PubMed ID
nsv471324 CNV gain 18288195
nsv615383 CNV loss 21841781
nsv6723 CNV deletion 18451855
nsv818724 CNV loss 17921354
nsv951769 CNV deletion 24416366

Variation tolerance for PTGES2 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGES2 Gene

Human Gene Mutation Database (HGMD)
PTGES2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGES2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGES2 Gene

Disorders for PTGES2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTGES2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
urinary tract papillary transitional cell benign neoplasm
  • inverted papilloma of urinary tract
bladder papillary transitional cell neoplasm
  • urinary bladder papillary urothelial neoplasm
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTGES2

Genetic Association Database (GAD)
PTGES2
Human Genome Epidemiology (HuGE) Navigator
PTGES2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGES2
genes like me logo Genes that share disorders with PTGES2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGES2 Gene

Publications for PTGES2 Gene

  1. Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort. (PMID: 19371221) Fischer A. … Illig T. (Genet Test Mol Biomarkers 2009) 3 22 46 64
  2. Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. (PMID: 17566096) Nitz I. … Illig T. (J. Clin. Endocrinol. Metab. 2007) 3 22 46 64
  3. Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome. (PMID: 17979097) Lindner I. … Schrezenmeir J. (Mol Nutr Food Res 2007) 3 22 46 64
  4. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. (PMID: 12804604) Watanabe K. … Ohmiya Y. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  5. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. (PMID: 12835322) Murakami M. … Kudo I. (J. Biol. Chem. 2003) 3 4 22 64

Products for PTGES2 Gene

Sources for PTGES2 Gene

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