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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGES2 Gene

protein-coding   GIFtS: 62
GCID: GC09M130882

prostaglandin E synthase 2

(Previous name: chromosome 9 open reading frame 15 )
(Previous symbol: C9orf15)
 Explore 15 diseases affiliated with
PTGES2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTGES2    

Aliases
for PTGES2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Prostaglandin E Synthase 21 2     Chromosome 9 Open Reading Frame 151
C9orf151 2 3     GBF-12
PGES22 3 5     Gamma-Interferon-Activated Transcriptional Element-Binding Factor 12
MPGES-21     GATE-Binding Factor 12
EC 5.3.99.33 8     Membrane-Associated Prostaglandin E Synthase 22
GBF12 5     Microsomal Prostaglandin E Synthase-22
FLJ140381     Microsomal Prostaglandin E Synthase 23

External Ids:    HGNC: 178221   Entrez Gene: 801422   Ensembl: ENSG000001483347   OMIM: 6081525   UniProtKB: Q9H7Z73   
ORGUL members:         
NONCODE:n408035 n408034    

Export aliases for PTGES2 gene to outside databases

Previous GC identifers: GC09M121997 GC09M122529 GC09M124336 GC09M126259 GC09M127962 GC09M129922 GC09M100497


Summaries
for PTGES2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTGES2:
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of
prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a
gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.
(provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
Function: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more
stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an
interaction with CEBPB; however, the relevance of transcription activation activity remains unclear

Gene Wiki entry for PTGES2


Genomic Views
for PTGES2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGES2 gene promoter:
         PPAR-gamma1   Tal-1   STAT3   PPAR-gamma2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTGES2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGES2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGES2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.12

PTGES2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGES2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130882:  view genomic region     (about GC identifiers)

Start:
 130,882,972 bp from pter      End:
 130,890,741 bp from pter
Size:
 7,770 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n408034
  • n408035
130882971 130886842 130890712 chr9

Proteins
for PTGES2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7 (See protein sequence)
Recommended Name: Prostaglandin E synthase 2  
Size: 377 amino acids; 41943 Da
Cofactor: Dihydrolipoic acid
Subunit: Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10
Subcellular location: Golgi apparatus membrane; Single-pass membrane protein
Subcellular location: Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthetized as a
Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form
is cytoplasmic and is enriched in the perinuclear region
Sequence caution: Sequence=CAI13822.1; Type=Erroneous gene model prediction;
Secondary accessions: Q53EW9 Q5SYV6 Q96GI0 Q96GL2

Explore the universe of human proteins at neXtProt for PTGES2: NX_Q9H7Z7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H7Z7

    • 4 DME Specific Peptides for PTGES2 (Q9H7Z7)
     YRKVPIL  PNLADLAV  QLNDSSVIISALKTY  LTLYQYKTCPFCSKVRAFLD 

    PTGES2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243264.1  NP_079348.1  NP_945176.1  

    ENSEMBL proteins: 
     ENSP00000345341   ENSP00000420171   ENSP00000411378   ENSP00000277462  

    Human Recombinant Protein Products: 
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    Novus Biologicals PTGES2 Proteins
    Novus Biologicals PTGES2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PTGES2
    Uscn Proteins for PTGES2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol IEA--
    GO:0016021integral to membrane IEA--


    PTGES2 for ontologies           About GeneDecksing



    PTGES2 Antibody Products: 
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    ThermoFisher Antibodies for PTGES2

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    Uscn ELISAs and CLIAs for PTGES2

    Protein Domains /
    Families
    for PTGES2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTGES2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002109 Glutaredoxin
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9H7Z7

    ProtoNet protein and cluster: Q9H7Z7

    1 Blocks protein family: IPB002109 Glutaredoxin

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Similarity: Belongs to the GST superfamily
    Similarity: Contains 1 glutaredoxin domain
    Similarity: Contains 1 GST C-terminal domain


    Function
    for PTGES2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Function: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more
    stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an
    interaction with CEBPB; however, the relevance of transcription activation activity remains unclear
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate

    Enzyme Number (IUBMB): EC 5.3.99.31 2

    miRNA
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    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmid: PTGES2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGES2 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0050220prostaglandin-E synthase activity IEA--


    PTGES2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PTGES2:
     Lamellipodia cells 

    Animal Models:
         Mouse knock-out Ptges2tm1Bhk for PTGES2
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ptges2):
     homeostasis/metabolism 

    PTGES2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTGES2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    		prostanoid biosynthesis0.50
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    2PKA activation in glucagon signalling
    		Neurophysiological process_PGE2-induced pain processing0.44
    		Neurophysiological process PGE2-induced pain processing0.44
    3Arachidonic acid metabolism
    		Arachidonic acid metabolism0.42
    		Eicosanoid Synthesis0.31
    4Immune response_IFN gamma signaling pathway
    		IFN-gamma pathway0.43
    5Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for PTGES2
        Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing


    2 GeneGo (Thomson Reuters) Pathways for PTGES2
        Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing

    3 BioSystems Pathways for PTGES2 
        Eicosanoid Synthesis
    IFN-gamma pathway
    prostanoid biosynthesis


    2         Kegg Pathways  (Kegg details for PTGES2):
        Arachidonic acid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Pathway: Lipid metabolism; prostaglandin biosynthesis


    PTGES2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGES2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/23 Interacting proteins for PTGES2 (Q9H7Z73 ENSP000003453414) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    EXOSC10Q017803, ENSP000003661354I2D: score=4 STRING: ENSP00000366135
    CEBPBP176763, ENSP000003054224I2D: score=1 STRING: ENSP00000305422
    PTGFRP430883, ENSP000003597934I2D: score=1 STRING: ENSP00000359793
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IEA--
    GO:0045454cell redox homeostasis IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IEA--
    GO:0046903secretion IEA--


    PTGES2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTGES2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGES2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PTGES2

    4 HMDB Compounds for PTGES2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PGH3prostaglandin H(,3) 42935-17-1--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    Prostaglandin H1PGH(,1) (see all 3)----
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--
    3 Novoseek chemical compound relationships for PTGES2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin 75 7 19347995 (3), 17697149 (1)
    pge2 69.1 10 17707523 (2), 12835322 (1), 19347995 (1), 17566096 (1) (see all 8)
    arachidonic acid 47.6 1 15225371 (1)

    Search CenterWatch for drugs/clinical trials and news about PTGES2 / PGES2 

    Transcripts
    for PTGES2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTGES2 gene (5 alternative transcripts): 
    NM_001256335.1  NM_025072.6  NM_198938.2  NM_198939.1  NM_198940.1  

    Unigene Cluster for PTGES2:

    Prostaglandin E synthase 2
    Hs.495219  [show with all ESTs]
    Unigene Representative Sequence: NM_025072
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338961(uc004bti.3 uc004btl.3) ENST00000492057 ENST00000496594
    ENST00000476811(uc004btk.3) ENST00000476655 ENST00000493205 ENST00000487063
    ENST00000474124 ENST00000449878 ENST00000476748 ENST00000483625 ENST00000497109
    ENST00000485510 ENST00000485237 ENST00000277462

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PTGES2:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmid: PTGES2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK024100.1 AK057049.1 AK223520.1 AK301618.1 BC009397.2 BC009456.1 BC011613.2 

    16 DOTS entries:

    DT.313899  DT.101982528  DT.100818961  DT.97761963  DT.92448074  DT.100818952  DT.100818947  DT.95169585 
    DT.100818953  DT.92448077  DT.92448086  DT.95169586  DT.95169588  DT.95169590  DT.100818957  DT.100832836 

    24/385 AceView cDNA sequences (see all 385):

    BM920989 NM_198939 CR616835 CR604511 BC009456 CB143539 AL578876 CR595131 
    BI333763 BE206604 AL532624 BM773132 AA586777 BM784125 CR606648 W21593 
    BQ278736 BM925813 CR591721 BM737876 CR596747 CR616554 BM470342 BM763321 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PTGES2 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^
    SP1:                                                                                      -     -           -                                                   
    SP2:                                            -     -     -           -     -           -     -           -                                                   
    SP3:                    -     -     -     -     -     -     -                             -                 -                                                   
    SP4:                    -     -     -     -     -     -     -                             -     -           -                                                   
    SP5:                                                              -     -                 -     -           -                                                   

    ExUns: 10a · 10b · 10c ^ 11a · 11b
    SP1:  -                           
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PTGES2

    Expression
    for PTGES2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGES2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGGCATCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PTGES2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGES2

    SOURCE GeneReport for Unigene cluster: Hs.495219

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Tissue specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and
    ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum;
    occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not
    in the thymus or lung. Overexpressed in colorectal cancer

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    Orthologs
    for PTGES2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTGES2 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ptges21 , 5 prostaglandin E synthase 21, 5 83.07(n)1
    83.51(a)1    		   2 (22.09 cM)5
    969791  NM_133783.21  NP_598544.21 
     323958965 
    chicken
    (Gallus gallus)    		 Aves PTGES21 prostaglandin E synthase 2 68.71(n)
    70.47(a)    		   417214  XM_415498.3  XP_415498.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PTGES26
    		 --
    		 72(a)
    		 1 ↔ 1
    		 AAWZ02041083(574-4912)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.249452 Xenopus laevis transcribed sequence with weak similarity more 76.11(n)    BU903846.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc565272 similar to prostaglandin E synthase 2 72.47(n)   393250  BC049325.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Su(P)1 Suppressor of ref(2)P sterility 54.04(n)
    43.75(a)    		   39856  NM_079392.3  NP_524116.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea R11A8.51 Protein R11A8.5 52.33(n)
    47.17(a)    		   177925  NM_069512.3  NP_501913.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G421501 Glutathione S-transferase family protein 53.52(n)
    48.83(a)    		   834220  NM_123580.1  NP_199030.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g02444001 hypothetical protein 53.52(n)
    51.61(a)    		   4335293  NM_001058837.1  NP_001052302.1 


    ENSEMBL Gene Tree for PTGES2 (if available)
    TreeFam Gene Tree for PTGES2 (if available) 

    Paralogs
    for PTGES2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PTGES2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/234 NCBI SNPs in PTGES2 are shown (see all 234)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs597699631,2
    		--100497152(+) TTGGTT/CCTGTC 3 -- ds50012Minor allele frequency- C:0.06CSA EA 122
    rs10474601,2
    		C--100497842(-) CGCTTC/TTAACA 3 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs557668251,2
    		--100498295(+) GTCTCG/ACCTGC 3 -- int11Minor allele frequency- A:0.50NA 2
    rs736696401,2
    		C,--100498976(+) GGGCCC/TGAAGC 3 -- int12Minor allele frequency- T:0.03WA 120
    rs78625231,2
    		C,F,H,--100499151(+) CCCCAC/TTCTGA 3 -- int18Minor allele frequency- T:0.03NS EA NA WA 542
    rs736696411,2
    		C,F,--100499684(+) CTCCCG/ACTGGT 3 -- int13Minor allele frequency- A:0.21WA CSA 122
    rs1124681551,2
    		C,F--100499792(+) CGCTTG/ACTGAT 6 /S syn12Minor allele frequency- A:0.00CSA NA 4554
    rs789445221,2
    		C,--100499956(+) CCACTC/GCCGCC 6 Q E mis10--------
    rs617326521,2
    		F--100500622(+) CTCGGA/TCACCT 6 T S mis11Minor allele frequency- T:0.07NS 42
    rs583476141,2
    		F,--100500769(+) CCCAGC/TCTCAG 3 -- int11Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for PTGES2 (130882972 - 130890741 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PTGES2
         1 CNV: 10310
    Human Gene Mutation Database (HGMD): PTGES2

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    Disorders / Diseases
    for PTGES2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTGES2 for disorders           About GeneDecksing

    OMIM gene information: 608152    OMIM disorders: --

    15 diseases for PTGES2:    About MalaCards
    patent ductus arteriosus    bladder transitional cell papilloma    epithelial ovarian cancer    ovarian cancer
    colorectal cancer    papilloma    skin cancer    hepatocellular carcinoma
    gingivitis    alzheimer's disease    colon cancer    osteoarthritis
    adenoma    melanoma    carcinoma

    3 Novoseek disease relationships for PTGES2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 18.6 1 12835322 (1)
    inflammation 12.2 1 12835322 (1)
    tumors 0 2 19347995 (2)

    Human Genome Epidemiology (HuGE) Navigator: PTGES2 (9 documents)

    Export disorders for PTGES2 gene to outside databases

    Publications
    for PTGES2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGES2 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with PTGES2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel type of membrane- associated prostaglandin E synthase. (PubMed id 11866447)1, 2, 3 Tanikawa N.... Watanabe K. (2002)
    2. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. (PubMed id 12835322)1, 2, 9 Murakami M.... Kudo I. (2003)
    3. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. (PubMed id 12804604)1, 2, 9 Watanabe K....Ohmiya Y. (2003)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. (PubMed id 19347995)1, 9 Mattila S....StenbAock F. (2009)
    9. IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta. (PubMed id 15879117)1, 9 Meng Q....Kalvakolanu D.V. (2005)
    10. A novel transactivating factor that regulates interferon-gamma-dependent gene expression. (PubMed id 12050152)1, 9 Hu J....Kalvakolanu D.V. (2002)

    External Searches for PTGES2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTGES2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80142 HGNC: 17822 AceView: PTGES2 Ensembl:ENSG00000148334 euGenes: HUgn80142
    ECgene: PTGES2 Kegg: 80142 H-InvDB: PTGES2

    Other Databases showing PTGES2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTGES2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGES2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PTGES2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTGES2 gene:
    Search GeneIP for patents involving PTGES2

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