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Aliases for PTGES2 Gene

Aliases for PTGES2 Gene

  • Prostaglandin E Synthase 2 2 3
  • PGES2 3 4 6
  • Membrane-Associated Prostaglandin E Synthase-2 3 4
  • Prostaglandin-H(2) E-Isomerase 3 4
  • MPGE Synthase-2 3 4
  • EC 5.3.99.3 4 63
  • C9orf15 3 4
  • MPGES-2 3 4
  • GBF1 3 6
  • Gamma-Interferon-Activated Transcriptional Element-Binding Factor 1 3
  • Membrane-Associated Prostaglandin E Synthase 2 3
  • Microsomal Prostaglandin E Synthase-2 3
  • Microsomal Prostaglandin E Synthase 2 4
  • Chromosome 9 Open Reading Frame 15 2
  • GATE-Binding Factor 1 3
  • GBF-1 3

External Ids for PTGES2 Gene

Previous Symbols for PTGES2 Gene

  • C9orf15

Summaries for PTGES2 Gene

Entrez Gene Summary for PTGES2 Gene

  • The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

GeneCards Summary for PTGES2 Gene

PTGES2 (Prostaglandin E Synthase 2) is a Protein Coding gene. Diseases associated with PTGES2 include patent ductus arteriosus and colorectal cancer. Among its related pathways are Metabolism and Arf1 pathway. GO annotations related to this gene include electron carrier activity and prostaglandin-E synthase activity.

UniProtKB/Swiss-Prot for PTGES2 Gene

  • Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

Gene Wiki entry for PTGES2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES2 Gene

Genomics for PTGES2 Gene

Genomic Location for PTGES2 Gene

Start:
128,120,693 bp from pter
End:
128,128,462 bp from pter
Size:
7,770 bases
Orientation:
Minus strand

Genomic View for PTGES2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES2 Gene

Regulatory Elements for PTGES2 Gene

Proteins for PTGES2 Gene

  • Protein details for PTGES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Z7-PGES2_HUMAN
    Recommended name:
    Prostaglandin E synthase 2
    Protein Accession:
    Q9H7Z7
    Secondary Accessions:
    • Q53EW9
    • Q5SYV6
    • Q96GI0
    • Q96GL2

    Protein attributes for PTGES2 Gene

    Size:
    377 amino acids
    Molecular mass:
    41943 Da
    Quaternary structure:
    • Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10.
    SequenceCaution:
    • Sequence=CAI13822.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PTGES2 Gene

Proteomics data for PTGES2 Gene at MOPED

Selected DME Specific Peptides for PTGES2 Gene

Post-translational modifications for PTGES2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys141

Other Protein References for PTGES2 Gene

Domains for PTGES2 Gene

Gene Families for PTGES2 Gene

Suggested Antigen Peptide Sequences for PTGES2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7Z7

UniProtKB/Swiss-Prot:

PGES2_HUMAN
Domain:
  • Contains 1 glutaredoxin domain.:
    • Q9H7Z7
  • Contains 1 GST C-terminal domain.:
    • Q9H7Z7
Family:
  • Belongs to the GST superfamily.:
    • Q9H7Z7
genes like me logo Genes that share domains with PTGES2: view

Function for PTGES2 Gene

Molecular function for PTGES2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot EnzymeRegulation: Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by dihydrolipoic acid, glutathione (GSH) and 2-mercaptoethanol.
UniProtKB/Swiss-Prot Function: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

Enzyme Numbers (IUBMB) for PTGES2 Gene

Gene Ontology (GO) - Molecular Function for PTGES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0009055 electron carrier activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0016829 lyase activity ISS --
genes like me logo Genes that share ontologies with PTGES2: view

Phenotypes for PTGES2 Gene

MGI mutant phenotypes for PTGES2:
inferred from 2 alleles
GenomeRNAi human phenotypes for PTGES2:
genes like me logo Genes that share phenotypes with PTGES2: view

Animal Models for PTGES2 Gene

MGI Knock Outs for PTGES2:

miRNA for PTGES2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PTGES2 Gene

Localization for PTGES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES2 Gene

Golgi apparatus membrane; Single-pass membrane protein.
Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGES2 Gene COMPARTMENTS Subcellular localization image for PTGES2 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 4
cytosol 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for PTGES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA --
GO:0005794 Golgi apparatus --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with PTGES2: view

Pathways for PTGES2 Gene

genes like me logo Genes that share pathways with PTGES2: view

UniProtKB/Swiss-Prot Q9H7Z7-PGES2_HUMAN

  • Pathway: Lipid metabolism; prostaglandin biosynthesis

Gene Ontology (GO) - Biological Process for PTGES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA --
GO:0045454 cell redox homeostasis IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
GO:0046903 secretion IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with PTGES2: view

Compounds for PTGES2 Gene

(4) HMDB Compounds for PTGES2 Gene

Compound Synonyms Cas Number PubMed IDs
PGH3
  • prostaglandin H(,3)
42935-17-1
Prostaglandin E2
  • (-)-Prostaglandin E2
363-24-6
Prostaglandin H1
  • PGH(,1)
Not Available
Prostaglandin H2
  • Prostaglandin-H2
42935-17-1

(3) Novoseek inferred chemical compound relationships for PTGES2 Gene

Compound -log(P) Hits PubMed IDs
prostaglandin 75 4
pge2 69.1 9
arachidonic acid 47.6 1
genes like me logo Genes that share compounds with PTGES2: view

Transcripts for PTGES2 Gene

Unigene Clusters for PTGES2 Gene

Prostaglandin E synthase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^
SP1: - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - -
SP8: - - -
SP9: - - - - - - -
SP10: -
SP11: - - -
SP12:
SP13: - - -
SP14:

ExUns: 10a · 10b · 10c ^ 11a · 11b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PTGES2 Gene

GeneLoc Exon Structure for
PTGES2
ECgene alternative splicing isoforms for
PTGES2

Expression for PTGES2 Gene

mRNA expression in normal human tissues for PTGES2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGES2 Gene

SOURCE GeneReport for Unigene cluster for PTGES2 Gene Hs.495219

mRNA Expression by UniProt/SwissProt for PTGES2 Gene

Q9H7Z7-PGES2_HUMAN
Tissue specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
genes like me logo Genes that share expressions with PTGES2: view

No data available for mRNA differential expression in normal tissues for PTGES2 Gene

Orthologs for PTGES2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTGES2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGES2 35
  • 99.12 (n)
  • 100 (a)
PTGES2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGES2 35
  • 86.9 (n)
  • 88.08 (a)
PTGES2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGES2 35
  • 88.26 (n)
  • 89.97 (a)
PTGES2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptges2 35
  • 83.07 (n)
  • 83.51 (a)
Ptges2 16
Ptges2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGES2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGES2 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptges2 35
  • 83.07 (n)
  • 84.04 (a)
chicken
(Gallus gallus)
Aves PTGES2 35
  • 71.7 (n)
  • 75.44 (a)
PTGES2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGES2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24945 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ptges2 35
  • 69.31 (n)
  • 72.92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5924 35
zebrafish
(Danio rerio)
Actinopterygii ptgesl 35
  • 63.36 (n)
  • 65.41 (a)
ptgesl 36
  • 57 (a)
OneToOne
zgc56527 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004992 35
  • 53.68 (n)
  • 47.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta Su(P) 35
  • 54.06 (n)
  • 44 (a)
Su(P) 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R11A8.5 35
  • 52.54 (n)
  • 47.71 (a)
R11A8.5 36
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42150 35
  • 54.91 (n)
  • 51.04 (a)
rice
(Oryza sativa)
Liliopsida Os04g0244400 35
  • 56.99 (n)
  • 56.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5225 36
  • 44 (a)
OneToOne
Species with no ortholog for PTGES2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTGES2 Gene

ENSEMBL:
Gene Tree for PTGES2 (if available)
TreeFam:
Gene Tree for PTGES2 (if available)

Paralogs for PTGES2 Gene

No data available for Paralogs for PTGES2 Gene

Variants for PTGES2 Gene

Sequence variations from dbSNP and Humsavar for PTGES2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs884115 -- 128,125,577(+) GGGGG(C/T)GGTAG intron-variant
rs1047453 -- 128,121,040(-) TCATT(C/T)TGCCC utr-variant-3-prime
rs1047460 -- 128,121,001(-) CGCTT(C/T)TAACA utr-variant-3-prime
rs2040004 -- 128,121,232(-) GATGC(A/G)TTCGA synonymous-codon, reference
rs3824578 -- 128,124,042(+) AAAGT(A/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGES2 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv471324 CNV Gain 18288195
nsv893890 CNV Loss 21882294
nsv818724 CNV Loss 17921354
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv6723 CNV Loss 18451855
nsv893893 CNV Loss 21882294
nsv893894 CNV Gain 21882294

Relevant External Links for PTGES2 Gene

HapMap Linkage Disequilibrium report
PTGES2
Human Gene Mutation Database (HGMD)
PTGES2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGES2 Gene

Disorders for PTGES2 Gene

(3) Novoseek inferred disease relationships for PTGES2 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 18.6 1
inflammation 12.2 1
tumors 0 2

Relevant External Links for PTGES2

Genetic Association Database (GAD)
PTGES2
Human Genome Epidemiology (HuGE) Navigator
PTGES2
genes like me logo Genes that share disorders with PTGES2: view

No data available for UniProtKB/Swiss-Prot for PTGES2 Gene

Publications for PTGES2 Gene

  1. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. (PMID: 12804604) Watanabe K. … Ohmiya Y. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. (PMID: 12835322) Murakami M. … Kudo I. (J. Biol. Chem. 2003) 3 4 23
  3. Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. (PMID: 17566096) Nitz I. … Illig T. (J. Clin. Endocrinol. Metab. 2007) 3 23 48
  4. Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort. (PMID: 19371221) Fischer A. … Illig T. (Genet Test Mol Biomarkers 2009) 3 23 48
  5. Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome. (PMID: 17979097) Lindner I. … Schrezenmeir J. (Mol Nutr Food Res 2007) 3 23 48

Products for PTGES2 Gene

Sources for PTGES2 Gene

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