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PTGES2 Gene

protein-coding   GIFtS: 66
GCID: GC09M130882

Prostaglandin E Synthase 2

(Previous name: chromosome 9 open reading frame 15)
(Previous symbol: C9orf15)
  See PTGES2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin E Synthase 21 2     GBF-12
C9orf151 2 3     Gamma-Interferon-Activated Transcriptional Element-Binding Factor 12
PGES22 3 5     GATE-Binding Factor 12
mPGES-22 3     Membrane-Associated Prostaglandin E Synthase 22
EC 5.3.99.33 8     Microsomal Prostaglandin E Synthase-22
GBF12 5     EC 4.1.2.-3
Chromosome 9 Open Reading Frame 151     Microsomal Prostaglandin E Synthase 23

External Ids:    HGNC: 178221   Entrez Gene: 801422   Ensembl: ENSG000001483347   OMIM: 6081525   UniProtKB: Q9H7Z73   

Export aliases for PTGES2 gene to outside databases

Previous GC identifers: GC09M121997 GC09M122529 GC09M124336 GC09M126259 GC09M127962 GC09M129922 GC09M100497


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTGES2 Gene:
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion
of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated
by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for
this gene. (provided by RefSeq, Jun 2009)

GeneCards Summary for PTGES2 Gene:
PTGES2 (prostaglandin E synthase 2) is a protein-coding gene. Diseases associated with PTGES2 include patent ductus arteriosus. GO annotations related to this gene include prostaglandin-E synthase activity and electron carrier activity.

UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
Function: Dual function enzyme which exhibits both isomerase and lyase activities. Its catalytic activity is
altered by the presence or absence of the cofactors glutathione (GSH) and heme. The GSH-heme complex-bound enzyme
(mPGES-2h) acts as a lyase and catalyzes the degradation of prostaglandin E2 H2 (PGH2) to
12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) while the GSH-heme
complex-free enzyme (mPGES-2) acts as an isomerase and catalyzes the isomerization of PGH2 into the more stable
prostaglandin E2 (PGE2) form (By similarity)

Gene Wiki entry for PTGES2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGES2 gene promoter:
         PPAR-gamma1   Tal-1   STAT3   PPAR-gamma2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGES2 promoter sequence
   Search Chromatin IP Primers for PTGES2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGES2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.12

PTGES2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGES2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130882:  view genomic region     (about GC identifiers)

Start:
130,882,972 bp from pter      End:
130,890,741 bp from pter
Size:
7,770 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PTGES2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7 (See protein sequence)
Recommended Name: Prostaglandin E synthase 2  
Size: 377 amino acids; 41943 Da
Cofactor: Dihydrolipoic acid; required for isomerase activity
Cofactor: Glutathione (GSH). Required for lyase activity (By similarity)
Cofactor: Heme. Required for lyase activity (By similarity)
Subunit: Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10
Sequence caution: Sequence=CAI13822.1; Type=Erroneous gene model prediction;
Secondary accessions: Q53EW9 Q5SYV6 Q96GI0 Q96GL2

Explore the universe of human proteins at neXtProt for PTGES2: NX_Q9H7Z7

Explore proteomics data for PTGES2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys141
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for PTGES2 (Q9H7Z7)
     YRKVPIL  PNLADLAV  QLNDSSVIISALKTY  LTLYQYKTCPFCSKVRAFLD 


    See PTGES2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243264.1  NP_079348.1  NP_945176.1  

    ENSEMBL proteins: 
     ENSP00000345341   ENSP00000411378   ENSP00000277462  

    PTGES2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for PTGES2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: mPGES2
    Prostaglandin synthases

    4 InterPro protein domains:
     IPR002109 Glutaredoxin
     IPR012336 Thioredoxin-like_fold
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9H7Z7

    ProtoNet protein and cluster: Q9H7Z7

    1 Blocks protein domain: IPB002109 Glutaredoxin

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Similarity: Belongs to the GST superfamily
    Similarity: Contains 1 glutaredoxin domain
    Similarity: Contains 1 GST C-terminal domain


    Find genes that share domains with PTGES2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGES2_HUMAN, Q9H7Z7
    Function: Dual function enzyme which exhibits both isomerase and lyase activities. Its catalytic activity is
    altered by the presence or absence of the cofactors glutathione (GSH) and heme. The GSH-heme complex-bound enzyme
    (mPGES-2h) acts as a lyase and catalyzes the degradation of prostaglandin E2 H2 (PGH2) to
    12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) while the GSH-heme
    complex-free enzyme (mPGES-2) acts as an isomerase and catalyzes the isomerization of PGH2 into the more stable
    prostaglandin E2 (PGE2) form (By similarity)
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = malonaldehyde +
    (5Z,8E,10E)-(12S)-hydroxyheptadeca-5,8,10-trienoate

         Enzyme Numbers (IUBMB): EC 5.3.99.31 2 EC 4.1.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016829lyase activity ISS--
    GO:0020037heme binding ISS--
         
    Find genes that share ontologies with PTGES2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PTGES2:
     Lamellipodia cells 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptges2):
     homeostasis/metabolism  immune system 

    Find genes that share phenotypes with PTGES2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PTGES2: Ptges2tm1Bhk Ptges2tm1Kymm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTGES2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGES2

    miRNA
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    miRTarBase miRNAs that target PTGES2:
    hsa-mir-193b-3p (MIRT016466), hsa-let-7a-5p (MIRT052529), hsa-let-7b-5p (MIRT052205), hsa-let-7c-5p (MIRT051829), hsa-mir-32-5p (MIRT028318)

    Block miRNA regulation of human, mouse, rat PTGES2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PTGES2:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidPTGES2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGES2_HUMAN, Q9H7Z7: Golgi apparatus membrane; Single-pass membrane protein
    PGES2_HUMAN, Q9H7Z7: Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthesized
    as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The
    truncated form is cytoplasmic and is enriched in the perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    mitochondrion4
    cytosol2
    nucleus2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PTGES2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTGES2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    C20 prostanoid biosynthesis0.00
    2Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    3Metabolism
    Metabolic pathways0.38
    4Ca-dependent events
    Neurophysiological process PGE2 induced pain processing0.38
    5Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM


    Find genes that share SuperPaths with PTGES2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for PTGES2
        Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing

    3 BioSystems Pathways for PTGES2
        Eicosanoid Synthesis
    C20 prostanoid biosynthesis
    IFN-gamma pathway


    2 Kegg Pathways  (Kegg details for PTGES2):
        Arachidonic acid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Pathway: Lipid metabolism; prostaglandin biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PTGES2
    Interactions:

        GeneGlobe Interaction Network for PTGES2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTGES2 (Q9H7Z73 ENSP000003453414) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    SQSTM1Q135013, ENSP000003744554I2D: score=1 STRING: ENSP00000374455
    EXOSC10Q017803, ENSP000003661354I2D: score=4 STRING: ENSP00000366135
    CEBPBP176763, ENSP000003054224I2D: score=1 STRING: ENSP00000305422
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IEA--
    GO:0045454cell redox homeostasis IEA--
    GO:0045893positive regulation of transcription, DNA-templated IEA--
    GO:0046903secretion IEA--

    Find genes that share ontologies with PTGES2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PTGES2 (PGES2)

    4 HMDB Compounds for PTGES2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PGH3prostaglandin H(,3) 42935-17-1--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    Prostaglandin H1PGH(,1) (see all 3)----
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--

    3 Novoseek inferred chemical compound relationships for PTGES2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostaglandin 75 7 19347995 (3), 17697149 (1)
    pge2 69.1 10 17707523 (2), 12835322 (1), 19347995 (1), 17566096 (1) (see all 8)
    arachidonic acid 47.6 1 15225371 (1)



    Find genes that share compounds with PTGES2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTGES2 gene (5 alternative transcripts): 
    NM_001256335.1  NM_025072.6  NM_198938.2  NM_198939.1  NM_198940.1  

    Unigene Cluster for PTGES2:

    Prostaglandin E synthase 2
    Hs.495219  [show with all ESTs]
    Unigene Representative Sequence: NM_025072
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338961(uc004bti.3 uc004btl.3) ENST00000496594 ENST00000476655
    ENST00000493205 ENST00000487063 ENST00000474124 ENST00000449878 ENST00000476748
    ENST00000483625 ENST00000497109 ENST00000485510 ENST00000485237 ENST00000277462

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    Additional mRNA sequence: 

    AK024100.1 AK057049.1 AK223520.1 AK301618.1 BC009397.2 BC009456.1 BC011613.2 

    16 DOTS entries:

    DT.313899  DT.101982528  DT.100818961  DT.97761963  DT.92448074  DT.100818952  DT.100818947  DT.95169585 
    DT.100818953  DT.92448077  DT.92448086  DT.95169586  DT.95169588  DT.95169590  DT.100818957  DT.100832836 

    Selected AceView cDNA sequences (see all 385):

    BM784125 AL578876 CR620072 AK024100 BQ639329 BQ072118 BM925813 BQ270561 
    CR595131 AA350806 BQ278736 W21593 BM773196 BM920870 BQ581757 AI087053 
    BM848261 AA346389 AA586777 BM920989 BE793528 BI333763 CR616835 CR594346 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTGES2 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^
    SP1:                                                                                      -     -           -                                                   
    SP2:                                            -     -     -           -     -           -     -           -                                                   
    SP3:                    -     -     -     -     -     -     -                             -                 -                                                   
    SP4:                    -     -     -     -     -     -     -                             -     -           -                                                   
    SP5:                                                              -     -                 -     -           -                                                   

    ExUns: 10a · 10b · 10c ^ 11a · 11b
    SP1:  -                           
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PTGES2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PTGES2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGCATCT
    PTGES2 Expression
    About this image


    PTGES2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PTGES2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTGES2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495219

    UniProtKB/Swiss-Prot: PGES2_HUMAN, Q9H7Z7
    Tissue specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria
    and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain:
    cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and
    trachea, but not in the thymus or lung. Overexpressed in colorectal cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTGES2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptges21 , 5 prostaglandin E synthase 21, 5 83.07(n)1
    83.51(a)1
      2 (22.09 cM)5
    969791  NM_133783.21  NP_598544.21 
     323958965 
    chicken
    (Gallus gallus)
    Aves PTGES21 prostaglandin E synthase 2 71.7(n)
    75.44(a)
      417214  XM_415498.4  XP_415498.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTGES26
    prostaglandin E synthase 2
    72(a)
    1 ↔ 1
    AAWZ02041083(574-5809)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.249452 Xenopus laevis transcribed sequence with weak similarity more 76.11(n)    BU903846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565272 similar to prostaglandin E synthase 2 72.47(n)   393250  BC049325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(P)1 Suppressor of ref(2)P sterility 54.06(n)
    44(a)
      39856  NM_079392.4  NP_524116.2 
    worm
    (Caenorhabditis elegans)
    Secernentea R11A8.51 R11A8.5 52.54(n)
    47.71(a)
      177925  NM_069512.4  NP_501913.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G421501 AT5G42150 54.91(n)
    51.04(a)
      834220  NM_123580.1  NP_199030.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g02444001 Os04g0244400 56.99(n)
    56.7(a)
      4335293  NM_001058837.1  NP_001052302.1 


    ENSEMBL Gene Tree for PTGES2 (if available)
    TreeFam Gene Tree for PTGES2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTGES2 (see all 293)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs597699631,2
    C,F--100497152(+) TTGGTT/CCTGTC 3 -- ds50012Minor allele frequency- C:0.06CSA EA 122
    rs1891873191,2
    --100497186(+) CTGGTA/GCCCTG 3 -- ds50010--------
    rs1452489621,2
    C--100497187(+) TGGTGC/TCCTGG 3 -- ds50010--------
    rs1157646331,2
    F--100497197(+) GACCAG/AGTGAC 3 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1170848211,2
    F--100497298(+) CTGCAG/CAGCCC 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1491759271,2
    --100497308(+) CCACCA/GTGGGT 3 -- ds50010--------
    rs1432815801,2
    --100497373(+) CTGAGA/TGGTAT 3 -- ds50010--------
    rs1161933181,2
    F--100497379(+) GGTATC/ACTGGG 3 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1816055381,2
    C--100497417(+) CGTACC/TGTGCC 3 -- ds50010--------
    rs1467958121,2
    --100497502(+) GACCGC/GCAGCC 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for PTGES2 (130882972 - 130890741 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PTGES2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8294n71CNV Loss21882294
    nsv893893CNV Loss21882294
    nsv6723CNV Loss18451855
    nsv893890CNV Loss21882294
    nsv818724CNV Loss17921354
    nsv893891CNV Loss21882294
    nsv893859CNV Loss21882294
    nsv893894CNV Gain21882294
    nsv471324CNV Gain18288195

    Human Gene Mutation Database (HGMD): PTGES2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGES2
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGES2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608152    OMIM disorders: --

    1 disease for PTGES2:    
    About MalaCards
    patent ductus arteriosus


    Find genes that share disorders with PTGES2           About GenesLikeMe

    3 Novoseek inferred disease relationships for PTGES2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 18.6 1 12835322 (1)
    inflammation 12.2 1 12835322 (1)
    tumors 0 2 19347995 (2)

    Genetic Association Database (GAD): PTGES2
    Human Genome Epidemiology (HuGE) Navigator: PTGES2 (9 documents)

    Export disorders for PTGES2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTGES2 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with PTGES2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel type of membrane- associated prostaglandin E synthase. (PubMed id 11866447)1, 2, 3 Tanikawa N.... Watanabe K. (Biochem. Biophys. Res. Commun. 2002)
    2. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. (PubMed id 12835322)1, 2, 9 Murakami M.... Kudo I. (J. Biol. Chem. 2003)
    3. Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome. (PubMed id 17979097)1, 4, 9 Lindner I....Schrezenmeir J. (amp 2007)
    4. Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. (PubMed id 17566096)1, 4, 9 Nitz I....Illig T. (J. Clin. Endocrinol. Metab. 2007)
    5. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. (PubMed id 12804604)1, 2, 9 Watanabe K....Ohmiya Y. (Biochem. Biophys. Res. Commun. 2003)
    6. Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort. (PubMed id 19371221)1, 4, 9 Fischer A....Illig T. (Genet Test Mol Biomarkers 2009)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    10. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. (PubMed id 17266179)1, 4 Fisher E....DAPring F. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80142 HGNC: 17822 AceView: PTGES2 Ensembl:ENSG00000148334 euGenes: HUgn80142
    ECgene: PTGES2 Kegg: 80142 H-InvDB: PTGES2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PTGES2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PTGES2 gene:
    Search GeneIP for patents involving PTGES2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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