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PTGES Gene

protein-coding   GIFtS: 63
GCID: GC09M132500

Prostaglandin E Synthase


(Previous symbol: MGST1L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin E Synthase1 2     P53-Induced Gene 121
MGST1L11 2 3 5     MGST-IV2
Microsomal Glutathione S-Transferase 1-Like 11 2 3     MPGES2
PGES2 3 5     PP1022
PIG122 3 5     PP12942
Glutathione S-Transferase 1-Like 11 2     TP53I122
MGST1-Like 11 2     mPGES-12
Microsomal Prostaglandin E Synthase-11 2     P53-Induced Apoptosis Protein 122
Tumor Protein P53 Inducible Protein 121 2     EC 5.3.99.33
Microsomal Prostaglandin E Synthase 12 3     MPGES-13
MGST1-L12 3     MPGES13
P53-Induced Gene 12 Protein2 3     

External Ids:    HGNC: 95991   Entrez Gene: 95362   Ensembl: ENSG000001483447   OMIM: 6051725   UniProtKB: O146843   

Export aliases for PTGES gene to outside databases

Previous GC identifers: GC09M123615 GC09M124147 GC09M125954 GC09M127876 GC09M129580 GC09M131540 GC09M102099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTGES Gene:
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene
has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be
induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice
suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain
during inflammatory responses. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTGES Gene:
PTGES (prostaglandin E synthase) is a protein-coding gene. GO annotations related to this gene include prostaglandin-E synthase activity and glutathione binding. An important paralog of this gene is MGST1.

UniProtKB/Swiss-Prot: PTGES_HUMAN, O14684
Function: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2)

Gene Wiki entry for PTGES Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGES gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTGES promoter sequence
   Search Chromatin IP Primers for PTGES

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.3

PTGES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGES gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M132500:  view genomic region     (about GC identifiers)

Start:
132,500,610 bp from pter      End:
132,515,344 bp from pter
Size:
14,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PTGES_HUMAN, O14684 (See protein sequence)
Recommended Name: Prostaglandin E synthase  
Size: 152 amino acids; 17102 Da
Cofactor: Glutathione
Subunit: Homotrimer
3 PDB 3D structures from and Proteopedia for PTGES:
3DWW (3D)        4AL0 (3D)        4AL1 (3D)    
Secondary accessions: O14900 Q5SZC0

Explore the universe of human proteins at neXtProt for PTGES: NX_O14684

Explore proteomics data for PTGES at MOPED


See PTGES Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004869.1  
ENSEMBL proteins: 
 ENSP00000342385  
Reactome Protein details: O14684

PTGES Human Recombinant Protein Products:

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antibodies-online proteins for PTGES (5 products) 

 
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antibodies-online antibodies for PTGES (42 products) 

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antibodies-online kits for PTGES (18 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: mPGES1
Prostaglandin synthases

2 InterPro protein domains:
 IPR023352 MAPEG-like_dom
 IPR001129 Membr-assoc_MAPEG

Graphical View of Domain Structure for InterPro Entry O14684

ProtoNet protein and cluster: O14684

1 Blocks protein domain: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

UniProtKB/Swiss-Prot: PTGES_HUMAN, O14684
Similarity: Belongs to the MAPEG family


Find genes that share domains with PTGES           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PTGES_HUMAN, O14684
Function: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2)
Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
(5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
Induction: By p53/TP53

     Enzyme Number (IUBMB): EC 5.3.99.31

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0043295glutathione binding IDA18682561
GO:0050220prostaglandin-E synthase activity IDA18682561
     
Find genes that share ontologies with PTGES           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for PTGES:
 Big cells  G0/1 arrest  Increased G1 DNA content 

     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptges):
 behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
 integument 

Find genes that share phenotypes with PTGES           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for PTGES: Ptgestm1Lpa Ptgestm1Aki

   genOway: Develop your customized and physiologically relevant rodent model for PTGES

miRNA
Products:
    
miRTarBase miRNAs that target PTGES:
hsa-mir-335-5p (MIRT017384), hsa-mir-125b-5p (MIRT046064), hsa-mir-124-3p (MIRT022404)

Block miRNA regulation of human, mouse, rat PTGES using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate PTGES
SwitchGear 3'UTR luciferase reporter plasmidPTGES 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for PTGES
Predesigned siRNA for gene silencing in human, mouse, rat PTGES

Gene Editing
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GenScript: all cDNA clones in your preferred vector: PTGES (NM_004878)
Sino Biological Human cDNA Clone for PTGES
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGES
Addgene plasmids for PTGES 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGES


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PTGES_HUMAN, O14684: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum4
extracellular2
nucleus2
peroxisome2
cytosol1
golgi apparatus1
lysosome1
mitochondrion1

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005641nuclear envelope lumen IEA--
GO:0005737cytoplasm ----
GO:0005789endoplasmic reticulum membrane TAS--
GO:0016020membrane TAS10377395
GO:0016021integral component of membrane IDA18682561

Find genes that share ontologies with PTGES           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PTGES About   (see all 7)  
See pathways by source

SuperPathContained pathways About
1Arachidonic acid metabolism
Arachidonic acid metabolism0.41
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.00
Arachidonic acid metabolism0.40
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
3PEDF Induced Signaling
all-trans-Retinoic Acid Signaling in Brain0.71
4Ca-dependent events
Neurophysiological process PGE2 induced pain processing0.38
5Prostaglandin 2 biosynthesis and metabolism FM
Prostaglandin 2 biosynthesis and metabolism FM


Find genes that share SuperPaths with PTGES           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PTGES
    all-trans-Retinoic Acid Signaling in Brain

2 GeneGo (Thomson Reuters) Pathways for PTGES
    Prostaglandin 2 biosynthesis and metabolism FM
Neurophysiological process PGE2-induced pain processing

1 BioSystems Pathway for PTGES
    Eicosanoid Synthesis


1 Reactome Pathway for PTGES
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

1 PharmGKB Pathway for PTGES
    Celecoxib Pathway, Pharmacodynamics

2 Kegg Pathways  (Kegg details for PTGES):
    Arachidonic acid metabolism
Metabolic pathways

    Pathway & Disease-focused RT2 Profiler PCR Array including PTGES: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for PTGES

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for PTGES (O146843 ENSP000003423854) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
PTGER1P349953, ENSP000002925134I2D: score=1 STRING: ENSP00000292513
PTGER2P431163, ENSP000002454574I2D: score=1 STRING: ENSP00000245457
CBR1ENSP000002903494STRING: ENSP00000290349
HPGDSENSP000002952564STRING: ENSP00000295256
PTGDSENSP000003606874STRING: ENSP00000360687
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Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001516prostaglandin biosynthetic process IDA18682561
GO:0002526acute inflammatory response IEA--
GO:0002544chronic inflammatory response IEA--
GO:0006693prostaglandin metabolic process TAS10377395
GO:0007165signal transduction NAS10377395

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PTGES

5 HMDB Compounds for PTGES    About this table
CompoundSynonyms CAS #PubMed Ids
Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
PGH3prostaglandin H(,3) 42935-17-1--
Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
Prostaglandin H1PGH(,1) (see all 3)----
Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--

Selected Novoseek inferred chemical compound relationships for PTGES gene (see all 21)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pge2 85.5 113 16336776 (3), 12528468 (2), 12818365 (2), 15225371 (2) (see all 52)
pgh2 82.3 7 12528468 (2), 15314505 (1), 15225371 (1), 16336776 (1) (see all 5)
prostaglandin 79.4 39 11514380 (1), 12835322 (1), 12432931 (1), 12519887 (1) (see all 18)
prostaglandin-h2 69.8 1 11029586 (1)
arachidonic acid 65.8 16 12414902 (1), 12519887 (1), 16303602 (1), 17244328 (1) (see all 12)
prostacyclin 47.6 8 12414902 (1), 19046748 (1), 16314486 (1), 17374734 (1) (see all 5)
(+-)-pgf2-alpha 44.3 1 16524686 (1)
15-deoxy-delta-12,14-prostaglandin j2 40.5 4 12885795 (2), 16495511 (1)
thromboxane 33.9 2 18952655 (1), 19423863 (1)
dexamethasone 31.6 5 11029586 (1), 15479233 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PTGES gene (2 alternative transcripts): 
NM_004878.4  NM_198797.1  

Unigene Cluster for PTGES:

Prostaglandin E synthase
Hs.146688  [show with all ESTs]
Unigene Representative Sequence: AK127663
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000481476(uc010myy.3) ENST00000340607(uc004byi.3)
miRNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGES
Addgene plasmids for PTGES 
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  QuantiTect SYBR Green Assays in human, mouse, rat PTGES
  QuantiFast Probe-based Assays in human, mouse, rat PTGES

Additional mRNA sequence: 

AF010316.1 AF027740.1 AF217965.1 AF217972.1 AK127663.1 AK311947.1 BC008280.1 BC018201.2 

9 DOTS entries:

DT.455479  DT.100703143  DT.91736910  DT.92002863  DT.91736909  DT.100694643  DT.95225589  DT.95290155 
DT.100039584 

Selected AceView cDNA sequences (see all 105):

CR610930 BQ927197 CR605510 BU169075 BU185857 CR618950 BQ949113 BU540717 
BM550187 CR620820 BU541516 BX439245 CD245477 BF685783 BQ928306 NM_004878 
BM018156 NM_198797 AF010316 BC018201 BM046469 BV200300 BE616884 AF217972 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PTGES expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PTGES Expression
About this image


PTGES expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 12) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 4 entries
         Bone Marrow
         HyStem+TGFbeta3+GDF5-induced MEL2 cells
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Mature Endothelial Cells Blood Brain Barrier
         Cerebral Cortex
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         HyStem+TGFbeta3+GDF5-induced MEL2 cells
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
PTGES Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PTGES Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.146688
    Pathway & Disease-focused RT2 Profiler PCR Array including PTGES: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for PTGES
OriGene qSTAR qPCR primer pairs in human, mouse for PTGES
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PTGES
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QuantiFast Probe-based Assays in human, mouse, rat PTGES
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGES

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PTGES gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ptges1 , 5 prostaglandin E synthase1, 5 83.33(n)1
79.61(a)1
  2 (21.75 cM)5
642921  NM_022415.31  NP_071860.11 
 308894715 
chicken
(Gallus gallus)
Aves PTGES1 prostaglandin E synthase 74.13(n)
71.33(a)
  417193  NM_001194983.1  NP_001181912.1 
lizard
(Anolis carolinensis)
Reptilia PTGES6
prostaglandin E synthase
72(a)
1 ↔ 1
AAWZ02038152(116-12310)
African clawed frog
(Xenopus laevis)
Amphibia Xl.194392 Xenopus laevis transcribed sequence with weak similarity to protein refNP_004869.1 (H.sapiens) prostaglandin E synthase; microsomal glutathione S-transferase 1-like 1 [Homo sapiens] less 73.31(n)    BQ385700.1 
zebrafish
(Danio rerio)
Actinopterygii ptges1 prostaglandin E synthase 66.17(n)
66.42(a)
  544666  NM_001014828.2  NP_001014828.1 
fruit fly
(Drosophila melanogaster)
Insecta Mgstl6
CG331786
(see all 3)
--
34(a)
30(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
X(20913512-20915134)
X(14976860-14977812)


ENSEMBL Gene Tree for PTGES (if available)
TreeFam Gene Tree for PTGES (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PTGES gene
MGST12  
1 SIMAP similar gene for PTGES using alignment to 1 protein entry:     PTGES_HUMAN:
MGST1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PTGES (see all 563)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1120462501,2
C,F--132500198(+) AGGGAC/AAGTGA 1 -- ds50011Minor allele frequency- A:0.00CSA 1
rs109884861,2
H--132500592(+) CACCAG/TGAACG 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
rs1901733791,2
C--132500611(+) AAGACA/GAGGTG 1 -- ds50010--------
rs455428311,2
C--132500826(-) GAGCTT/CTGGGT 1 -- ut313Minor allele frequency- C:0.04NS NA WA 166
rs18019781,2
C,F,A,H--132500848(-) AGGGCA/TGTGGG 1 -- ut31 ese311Minor allele frequency- T:0.17EA NA NS WA CSA 621
rs38925371,2
C,F,H--132500907(+) CCCTCC/ACACCC 1 -- ut31 ese34Minor allele frequency- A:0.04NA MN WA 306
rs454558921,2
C--132500972(-) GCTGAC/TGCTTC 1 -- ut311Minor allele frequency- T:0.02NS 46
rs455447371,2
C,F--132500980(-) CTGCCC/TCCGCT 1 -- ut312Minor allele frequency- T:0.08NS NA 166
rs38925381,2
C,F,H--132501068(+) ACTGGC/TAGGGG 1 -- ut31 ese313Minor allele frequency- T:0.02EA NA NS MN WA 1484
rs1827925971,2
--132501185(+) GAGGCC/TGGTGG 1 -- ut310--------

HapMap Linkage Disequilibrium report for PTGES (132500610 - 132515344 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for PTGES:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6728CNV Loss18451855
nsv893924CNV Loss21882294
nsv893919CNV Loss21882294
nsv893927CNV Loss21882294
nsv893926CNV Gain21882294
nsv893925CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605172    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for PTGES:
Osteoarthritis

Find genes that share disorders with PTGES           About GenesLikeMe

Selected Novoseek inferred disease relationships for PTGES gene (see all 19)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 25.5 8 16911359 (2), 17505022 (1), 19228061 (1), 18703630 (1) (see all 5)
adenocarcinoma 22.5 6 17022010 (3), 18477251 (1), 17868774 (1)
nsclc 20.8 2 16314486 (1), 15386340 (1)
adenoma 17.9 1 20086108 (1)
rheumatoid arthritis 16.5 1 14558087 (1)
colorectal cancer 13.4 6 12818365 (1), 16495511 (1), 19412621 (1), 16538022 (1)
arthritis 12.6 3 15910650 (2), 11067848 (1)
cancer 11.6 12 18477251 (3), 11555570 (1), 16533161 (1), 17546626 (1) (see all 7)
tumors 11 8 20042640 (1), 15629771 (1), 18477251 (1), 18980437 (1) (see all 8)
cancer lung 10.3 2 17374734 (2)

Genetic Association Database (GAD): PTGES
Human Genome Epidemiology (HuGE) Navigator: PTGES (19 documents)

Export disorders for PTGES gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PTGES gene, integrated from 10 sources (see all 228):
(articles sorted by number of sources associating them with PTGES)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A model for p53-induced apoptosis. (PubMed id 9305847)1, 2, 3 Polyak K.... Vogelstein B. (Nature 1997)
  2. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4, 9 Lemaitre R.N....Psaty B.M. (Atherosclerosis 2009)
  3. Human glutathione dependent prostaglandin E synthase: gene structure and regulation. (PubMed id 10760517)1, 2, 9 Forsberg L.... Jakobsson P.J. (FEBS Lett. 2000)
  4. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PubMed id 20086108)1, 4, 9 Poole E.M....Ulrich C.M. (amp 2010)
  5. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PubMed id 19276290)1, 4, 9 Abraham J.E....Pharoah P.D. (Clin. Cancer Res. 2009)
  6. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PubMed id 18038187)1, 4, 9 Hoeft B....Nieters A. (amp 2008)
  7. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)1, 4, 9 Iwai N....Shioji K. (J. Hypertens. 2004)
  8. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. (PubMed id 10377395)1, 2, 9 Jakobsson P.-J.... Samuelsson B. (Proc. Natl. Acad. Sci. U.S.A. 1999)
  9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
  10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9536 HGNC: 9599 AceView: PTGES Ensembl:ENSG00000148344 euGenes: HUgn9536
ECgene: PTGES Kegg: 9536 H-InvDB: PTGES

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PTGES Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PTGES Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PTGES gene:
Search GeneIP for patents involving PTGES

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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