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Aliases for PTGES Gene

Aliases for PTGES Gene

  • Prostaglandin E Synthase 2 3
  • Microsomal Glutathione S-Transferase 1-Like 1 2 3 4
  • MGST1L1 3 4 6
  • PIG12 3 4 6
  • PGES 3 4 6
  • Tumor Protein P53 Inducible Protein 12 2 3
  • Microsomal Prostaglandin E Synthase-1 2 3
  • Microsomal Prostaglandin E Synthase 1 3 4
  • Glutathione S-Transferase 1-Like 1 2 3
  • P53-Induced Gene 12 Protein 3 4
  • MGST1-Like 1 2 3
  • MGST1-L1 3 4
  • MPGES-1 3 4
  • P53-Induced Apoptosis Protein 12 3
  • P53-Induced Gene 12 2
  • EC 5.3.99.3 4
  • MGST-IV 3
  • TP53I12 3
  • PP1294 3
  • MPGES1 4
  • MPGES 3
  • PP102 3

External Ids for PTGES Gene

Previous HGNC Symbols for PTGES Gene

  • MGST1L1

Previous GeneCards Identifiers for PTGES Gene

  • GC09M123615
  • GC09M124147
  • GC09M125954
  • GC09M127876
  • GC09M129580
  • GC09M131540
  • GC09M132500
  • GC09M102099

Summaries for PTGES Gene

Entrez Gene Summary for PTGES Gene

  • The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGES Gene

PTGES (Prostaglandin E Synthase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include glutathione binding and prostaglandin-E synthase activity. An important paralog of this gene is MGST1.

UniProtKB/Swiss-Prot for PTGES Gene

  • Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).

Gene Wiki entry for PTGES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES Gene

Genomics for PTGES Gene

Regulatory Elements for PTGES Gene

Transcription factor binding sites by QIAGEN in the PTGES gene promoter:

Genomic Location for PTGES Gene

Start:
129,738,331 bp from pter
End:
129,753,065 bp from pter
Size:
14,735 bases
Orientation:
Minus strand

Genomic View for PTGES Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES Gene

Proteins for PTGES Gene

  • Protein details for PTGES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14684-PTGES_HUMAN
    Recommended name:
    Prostaglandin E synthase
    Protein Accession:
    O14684
    Secondary Accessions:
    • O14900
    • Q5SZC0

    Protein attributes for PTGES Gene

    Size:
    152 amino acids
    Molecular mass:
    17102 Da
    Cofactor:
    Name=glutathione; Xref=ChEBI:CHEBI:57925;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for PTGES Gene

neXtProt entry for PTGES Gene

Proteomics data for PTGES Gene at MOPED

Post-translational modifications for PTGES Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGES Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTGES Gene

Domains for PTGES Gene

Gene Families for PTGES Gene

Suggested Antigen Peptide Sequences for PTGES Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14684

UniProtKB/Swiss-Prot:

PTGES_HUMAN :
  • O14684
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with PTGES: view

Function for PTGES Gene

Molecular function for PTGES Gene

UniProtKB/Swiss-Prot CatalyticActivity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
UniProtKB/Swiss-Prot Induction: By p53/TP53.

Enzyme Numbers (IUBMB) for PTGES Gene

Gene Ontology (GO) - Molecular Function for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043295 glutathione binding IDA 18682561
GO:0050220 prostaglandin-E synthase activity IDA 18682561
genes like me logo Genes that share ontologies with PTGES: view
genes like me logo Genes that share phenotypes with PTGES: view

Animal Models for PTGES Gene

MGI Knock Outs for PTGES:

Animal Model Products

miRNA for PTGES Gene

miRTarBase miRNAs that target PTGES

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGES

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PTGES Gene

Localization for PTGES Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGES Gene COMPARTMENTS Subcellular localization image for PTGES gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
nucleus 2
peroxisome 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005641 nuclear envelope lumen IEA --
GO:0005737 cytoplasm --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane TAS 10377395
GO:0016021 integral component of membrane IDA 18682561
genes like me logo Genes that share ontologies with PTGES: view

Pathways for PTGES Gene

genes like me logo Genes that share pathways with PTGES: view

Pathways by source for PTGES Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 18682561
GO:0002526 acute inflammatory response IEA --
GO:0002544 chronic inflammatory response IEA --
GO:0006693 prostaglandin metabolic process TAS 10377395
GO:0007165 signal transduction NAS 10377395
genes like me logo Genes that share ontologies with PTGES: view

Compounds for PTGES Gene

(5) HMDB Compounds for PTGES Gene

Compound Synonyms Cas Number PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8
PGH3
  • prostaglandin H(,3)
42935-17-1
Prostaglandin E2
  • (-)-Prostaglandin E2
363-24-6
Prostaglandin H1
  • PGH(,1)
Not Available
Prostaglandin H2
  • Prostaglandin-H2
42935-17-1

(21) Novoseek inferred chemical compound relationships for PTGES Gene

Compound -log(P) Hits PubMed IDs
pge2 85.5 60
pgh2 82.3 6
prostaglandin 79.4 18
prostaglandin-h2 69.8 1
arachidonic acid 65.8 12
genes like me logo Genes that share compounds with PTGES: view

Transcripts for PTGES Gene

mRNA/cDNA for PTGES Gene

Unigene Clusters for PTGES Gene

Prostaglandin E synthase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGES

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES Gene

No ASD Table

Relevant External Links for PTGES Gene

GeneLoc Exon Structure for
PTGES
ECgene alternative splicing isoforms for
PTGES

Expression for PTGES Gene

mRNA expression in normal human tissues for PTGES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGES Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.6) and Skin - Sun Exposed (Lower leg) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTGES Gene

SOURCE GeneReport for Unigene cluster for PTGES Gene Hs.146688

genes like me logo Genes that share expressions with PTGES: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PTGES Gene

Orthologs for PTGES Gene

This gene was present in the common ancestor of animals.

Orthologs for PTGES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGES 35
  • 99.12 (n)
  • 98.03 (a)
PTGES 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGES 35
  • 88.38 (n)
  • 85.53 (a)
PTGES 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGES 35
  • 88.81 (n)
  • 85.62 (a)
PTGES 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptges 35
  • 83.33 (n)
  • 79.61 (a)
Ptges 16
Ptges 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGES 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGES 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptges 35
  • 82.46 (n)
  • 80.26 (a)
chicken
(Gallus gallus)
Aves PTGES 35
  • 74.13 (n)
  • 71.33 (a)
PTGES 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGES 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19439 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ptges 35
  • 69.01 (n)
  • 64.08 (a)
zebrafish
(Danio rerio)
Actinopterygii ptges 35
  • 66.17 (n)
  • 66.42 (a)
ptges 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33177 36
  • 28 (a)
ManyToMany
CG33178 36
  • 30 (a)
ManyToMany
Mgstl 36
  • 34 (a)
ManyToMany
Species with no ortholog for PTGES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGES Gene

ENSEMBL:
Gene Tree for PTGES (if available)
TreeFam:
Gene Tree for PTGES (if available)

Paralogs for PTGES Gene

Paralogs for PTGES Gene

Selected SIMAP similar genes for PTGES Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTGES: view

Variants for PTGES Gene

Sequence variations from dbSNP and Humsavar for PTGES Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs920658 -- 129,749,956(-) TCAGC(A/G)CGGAG intron-variant
rs1134679 -- 129,739,433(-) TGTGT(A/G)TGTGT utr-variant-3-prime
rs1134680 -- 129,739,427(-) TGTGT(A/G)TGTGT utr-variant-3-prime
rs1801978 -- 129,738,569(-) AGGGC(A/T)GTGGG utr-variant-3-prime
rs1808903 -- 129,751,611(-) ACCTC(C/T)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGES Gene

Variant ID Type Subtype PubMed ID
nsv893919 CNV Loss 21882294
nsv893924 CNV Loss 21882294
nsv893925 CNV Gain 21882294
nsv893926 CNV Gain 21882294
nsv893927 CNV Loss 21882294
nsv6728 CNV Loss 18451855

Relevant External Links for PTGES Gene

HapMap Linkage Disequilibrium report
PTGES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGES Gene

Disorders for PTGES Gene

(1) University of Copenhagen DISEASES for PTGES Gene

(19) Novoseek inferred disease relationships for PTGES Gene

Disease -log(P) Hits PubMed IDs
inflammation 25.5 6
adenocarcinoma 22.5 5
nsclc 20.8 2
adenoma 17.9 1
rheumatoid arthritis 16.5 1

Relevant External Links for PTGES

Genetic Association Database (GAD)
PTGES
Human Genome Epidemiology (HuGE) Navigator
PTGES
genes like me logo Genes that share disorders with PTGES: view

No data available for UniProtKB/Swiss-Prot for PTGES Gene

Publications for PTGES Gene

  1. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. (PMID: 10377395) Jakobsson P.-J. … Samuelsson B. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  2. Human glutathione dependent prostaglandin E synthase: gene structure and regulation. (PMID: 10760517) Forsberg L. … Jakobsson P.J. (FEBS Lett. 2000) 3 4 23
  3. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PMID: 15167446) Iwai N. … Shioji K. (J. Hypertens. 2004) 3 23 48
  4. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PMID: 18038187) Hoeft B. … Nieters A. (Cancer Causes Control 2008) 3 23 48
  5. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre R.N. … Psaty B.M. (Atherosclerosis 2009) 3 23 48

Products for PTGES Gene

  • Addgene plasmids for PTGES

Sources for PTGES Gene

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