Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGES Gene

protein-coding   GIFtS: 64
GCID: GC09M132500

Prostaglandin E Synthase


(Previous symbol: MGST1L1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prostaglandin E Synthase1 2     P53-Induced Gene 121
MGST1L11 2 3 5     MGST-IV2
Microsomal Glutathione S-Transferase 1-Like 11 2 3     MPGES2
PGES2 3 5     PP1022
PIG122 3 5     PP12942
Glutathione S-Transferase 1-Like 11 2     TP53I122
MGST1-Like 11 2     mPGES-12
Microsomal Prostaglandin E Synthase-11 2     P53-Induced Apoptosis Protein 122
Tumor Protein P53 Inducible Protein 121 2     EC 5.3.99.33
Microsomal Prostaglandin E Synthase 12 3     MPGES-13
MGST1-L12 3     MPGES13
P53-Induced Gene 12 Protein2 3     

External Ids:    HGNC: 95991   Entrez Gene: 95362   Ensembl: ENSG000001483447   OMIM: 6051725   UniProtKB: O146843   

Export aliases for PTGES gene to outside databases

Previous GC identifers: GC09M123615 GC09M124147 GC09M125954 GC09M127876 GC09M129580 GC09M131540 GC09M102099


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGES Gene:
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene
has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be
induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice
suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain
during inflammatory responses. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTGES Gene: 
PTGES (prostaglandin E synthase) is a protein-coding gene. Diseases associated with PTGES include pleurisy, and patent ductus arteriosus, and among its related super-pathways are Metabolic pathways and Arachidonic acid metabolism. GO annotations related to this gene include prostaglandin-E synthase activity and glutathione binding. An important paralog of this gene is MGST1.

UniProtKB/Swiss-Prot: PTGES_HUMAN, O14684
Function: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2)

Gene Wiki entry for PTGES Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGES gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTGES promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGES

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.3

PTGES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGES gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M132500:  view genomic region     (about GC identifiers)

Start:
132,500,610 bp from pter      End:
132,515,344 bp from pter
Size:
14,735 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTGES_HUMAN, O14684 (See protein sequence)
Recommended Name: Prostaglandin E synthase  
Size: 152 amino acids; 17102 Da
Cofactor: Glutathione
Subunit: Homotrimer
Subcellular location: Membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for PTGES:
3DWW (3D)        4AL0 (3D)        4AL1 (3D)    
Secondary accessions: O14900 Q5SZC0

Explore the universe of human proteins at neXtProt for PTGES: NX_O14684

Explore proteomics data for PTGES at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14684

  • PTGES Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGES Protein Expression
    REFSEQ proteins: NP_004869.1  
    ENSEMBL proteins: 
     ENSP00000342385  
    Reactome Protein details: O14684
    Human Recombinant Protein Products for PTGES: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PTGES
    OriGene Protein Over-expression Lysate for PTGES
    OriGene MassSpec for PTGES 
    OriGene Custom Protein Services for PTGES
    GenScript Custom Purified and Recombinant Proteins Services for PTGES
    Novus Biologicals PTGES Proteins
    Novus Biologicals PTGES Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PTGES 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005641nuclear envelope lumen IEA--
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane TAS10377395
    GO:0016021integral to membrane IDA18682561

    PTGES for ontologies           About GeneDecksing



    PTGES Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PTGES
    GenScript Custom Superior Antibodies Services for PTGES
    Novus Biologicals PTGES Antibodies
    Abcam antibodies for PTGES
    Cloud-Clone Corp. Antibodies for PTGES 
    ThermoFisher Antibodies for PTGES
    LSBio Antibodies in human, mouse, rat for PTGES 

    Assay Products for PTGES: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PTGES
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PTGES
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTGES 
    Cloud-Clone Corp. CLIAs for PTGES


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: mPGES1 
    Prostaglandin synthases

    2 InterPro protein domains:
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry O14684

    ProtoNet protein and cluster: O14684

    1 Blocks protein domain: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

    UniProtKB/Swiss-Prot: PTGES_HUMAN, O14684
    Similarity: Belongs to the MAPEG family


    PTGES for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTGES_HUMAN, O14684
    Function: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2)
    Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
    Induction: By p53/TP53

         Enzyme Number (IUBMB): EC 5.3.99.31

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043295glutathione binding IDA18682561
    GO:0050220prostaglandin-E synthase activity IDA18682561
         
    PTGES for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTGES:
     Big cells  G0/1 arrest  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptges):
     behavior/neurological  cellular  homeostasis/metabolism  immune system  integument 

    PTGES for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTGES: Ptgestm1Lpa Ptgestm1Aki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGES 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGES 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGES 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGES
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PTGES
    SwitchGear 3'UTR luciferase reporter plasmidPTGES 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGES

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PTGES
    Sirion Biotech Customized adenovirus for overexpression of PTGES

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PTGES (see all 7)
    OriGene ORF clones in mouse, rat for PTGES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGES (NM_004878)
    Sino Biological Human cDNA Clone for PTGES
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGES
    Sirion Biotech Customized lentivirus for stable overexpression of PTGES 
                         Customized lentivirus expression plasmids for stable overexpression of PTGES 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PTGES
    Search LifeMap BioReagents cell lines for PTGES
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGES


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTGES About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Arachidonic acid metabolism0.44
    3Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.42
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    4PEDF Induced Signaling
    all-trans-Retinoic Acid Signaling in Brain0.71
    5PKA activation in glucagon signalling
    Neurophysiological process PGE2-induced pain processing0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PTGES
        Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTGES
        all-trans-Retinoic Acid Signaling in Brain

    2 GeneGo (Thomson Reuters) Pathways for PTGES
        Prostaglandin 2 biosynthesis and metabolism FM
    Neurophysiological process PGE2-induced pain processing

    1 BioSystems Pathway for PTGES
        Eicosanoid Synthesis


    4        Reactome Pathways for PTGES
        Metabolism
    Arachidonic acid metabolism
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Metabolism of lipids and lipoproteins

    1 PharmGKB Pathway for PTGES
        Celecoxib Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for PTGES):
        Arachidonic acid metabolism
    Metabolic pathways


    PTGES for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for PTGES (O146843 ENSP000003423854) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTGER1P349953, ENSP000002925134I2D: score=1 STRING: ENSP00000292513
    PTGER2P431163, ENSP000002454574I2D: score=1 STRING: ENSP00000245457
    CBR1ENSP000002903494STRING: ENSP00000290349
    HPGDSENSP000002952564STRING: ENSP00000295256
    PTGDSENSP000003606874STRING: ENSP00000360687
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IDA18682561
    GO:0002526acute inflammatory response IEA--
    GO:0002544chronic inflammatory response IEA--
    GO:0006693prostaglandin metabolic process TAS10377395
    GO:0007165signal transduction NAS10377395

    PTGES for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGES for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTGES

    5 HMDB Compounds for PTGES    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    PGH3prostaglandin H(,3) 42935-17-1--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    Prostaglandin H1PGH(,1) (see all 3)----
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--

    10/21 Novoseek inferred chemical compound relationships for PTGES gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pge2 85.5 113 16336776 (3), 12528468 (2), 12818365 (2), 15225371 (2) (see all 52)
    pgh2 82.3 7 12528468 (2), 15314505 (1), 15225371 (1), 16336776 (1) (see all 5)
    prostaglandin 79.4 39 11514380 (1), 12835322 (1), 12432931 (1), 12519887 (1) (see all 18)
    prostaglandin-h2 69.8 1 11029586 (1)
    arachidonic acid 65.8 16 12414902 (1), 12519887 (1), 16303602 (1), 17244328 (1) (see all 12)
    prostacyclin 47.6 8 12414902 (1), 19046748 (1), 16314486 (1), 17374734 (1) (see all 5)
    (+-)-pgf2-alpha 44.3 1 16524686 (1)
    15-deoxy-delta-12,14-prostaglandin j2 40.5 4 12885795 (2), 16495511 (1)
    thromboxane 33.9 2 18952655 (1), 19423863 (1)
    dexamethasone 31.6 5 11029586 (1), 15479233 (1)

    Search CenterWatch for drugs/clinical trials and news about PTGES

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTGES gene (2 alternative transcripts): 
    NM_004878.4  NM_198797.1  

    Unigene Cluster for PTGES:

    Prostaglandin E synthase
    Hs.146688  [show with all ESTs]
    Unigene Representative Sequence: AK127663
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481476(uc010myy.3) ENST00000340607(uc004byi.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGES
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PTGES
    SwitchGear 3'UTR luciferase reporter plasmidPTGES 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PTGES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGES
    Clone
    Products:
         
    OriGene clones in human, mouse for PTGES (see all 7)
    OriGene ORF clones in mouse, rat for PTGES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTGES (NM_004878)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGES
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGES
    Sirion Biotech Customized lentivirus for stable overexpression of PTGES 
                         Customized lentivirus expression plasmids for stable overexpression of PTGES 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PTGES
    OriGene qSTAR qPCR primer pairs in human, mouse for PTGES
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGES
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGES
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGES

    Additional mRNA sequence: 

    AF010316.1 AF027740.1 AF217965.1 AF217972.1 AK127663.1 AK311947.1 BC008280.1 BC018201.2 

    9 DOTS entries:

    DT.455479  DT.100703143  DT.91736910  DT.92002863  DT.91736909  DT.100694643  DT.95225589  DT.95290155 
    DT.100039584 

    24/105 AceView cDNA sequences (see all 105):

    CR610930 BQ927197 BU541516 BU169075 BX439245 CR605510 CR618950 BU185857 
    BU540717 CR620820 BQ949113 BM550187 BG333197 BC018201 BM083445 BI085451 
    AA594663 BQ920029 BX357872 BQ928306 BU542016 BQ949151 CD245477 BM046469 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGES expression in normal human tissues (normalized intensities)      PTGES embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTGES Expression
    About this image


    PTGES expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Human Villous Capillary Endothelial Cells (HVCEC)   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Trabecular Meshwork Cells (HTMC)   

    See PTGES Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGES

    SOURCE GeneReport for Unigene cluster: Hs.146688
        SABiosciences Expression via Pathway-Focused PCR Array including PTGES: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PTGES
    OriGene qSTAR qPCR primer pairs in human, mouse for PTGES
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTGES
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGES
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGES
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTGES gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptges1 , 5 prostaglandin E synthase1, 5 83.33(n)1
    79.61(a)1
      2 (21.75 cM)5
    642921  NM_022415.31  NP_071860.11 
     308894715 
    chicken
    (Gallus gallus)
    Aves PTGES1 prostaglandin E synthase 74.13(n)
    71.33(a)
      417193  NM_001194983.1  NP_001181912.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTGES6
    prostaglandin E synthase
    70(a)
    1 ↔ 1
    AAWZ02038152(116-12310)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194392 Xenopus laevis transcribed sequence with weak similarity to protein refNP_004869.1 (H.sapiens) prostaglandin E synthase; microsomal glutathione S-transferase 1-like 1 [Homo sapiens] less 73.31(n)    BQ385700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ptges1 prostaglandin E synthase 66.17(n)
    66.42(a)
      544666  NM_001014828.2  NP_001014828.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mgstl6
    CG331776
    (see all 3)
    --
    34(a)
    29(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(20913512-20915134)
    X(14975582-14976226)


    ENSEMBL Gene Tree for PTGES (if available)
    TreeFam Gene Tree for PTGES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGES gene
    MGST12  
    1 SIMAP similar gene for PTGES using alignment to 1 protein entry:     PTGES_HUMAN:
    MGST1

    PTGES for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/563 SNPs in PTGES are shown (see all 563)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120462501,2
    C,F--132500198(+) AGGGAC/AAGTGA 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs109884861,2
    H--132500592(+) CACCAG/TGAACG 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1901733791,2
    C--132500611(+) AAGACA/GAGGTG 1 -- ds50010--------
    rs455428311,2
    C--132500826(-) GAGCTT/CTGGGT 1 -- ut313Minor allele frequency- C:0.04NS NA WA 166
    rs18019781,2
    C,F,A,H--132500848(-) AGGGCA/TGTGGG 1 -- ut31 ese311Minor allele frequency- T:0.17EA NA NS WA CSA 621
    rs38925371,2
    C,F,H--132500907(+) CCCTCC/ACACCC 1 -- ut31 ese34Minor allele frequency- A:0.04NA MN WA 306
    rs454558921,2
    C--132500972(-) GCTGAC/TGCTTC 1 -- ut311Minor allele frequency- T:0.02NS 46
    rs455447371,2
    C,F--132500980(-) CTGCCC/TCCGCT 1 -- ut312Minor allele frequency- T:0.08NS NA 166
    rs38925381,2
    C,F,H--132501068(+) ACTGGC/TAGGGG 1 -- ut31 ese313Minor allele frequency- T:0.02EA NA NS MN WA 1484
    rs1827925971,2
    --132501185(+) GAGGCC/TGGTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PTGES (132500610 - 132515344 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PTGES:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6728CNV Loss18451855
    nsv893924CNV Loss21882294
    nsv893919CNV Loss21882294
    nsv893927CNV Loss21882294
    nsv893926CNV Gain21882294
    nsv893925CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGES
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605172    OMIM disorders: --

    20/41 diseases for PTGES (see all 41):    About MalaCards
    pleurisy    patent ductus arteriosus    gastric ulcer    arthritis
    gastritis    breast cancer susceptibility    keloids    gastric adenocarcinoma
    gingivitis    esophageal adenocarcinoma    esophageal cancer    gastric cancer
    medulloblastoma    cervicitis    osteoarthritis    endometriosis
    colorectal cancer    rheumatoid arthritis    inflammatory bowel disease    periodontitis

    1 disease from the University of Copenhagen DISEASES database for PTGES:
    Osteoarthritis

    PTGES for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/19 Novoseek inferred disease relationships for PTGES gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 25.5 8 16911359 (2), 17505022 (1), 19228061 (1), 18703630 (1) (see all 5)
    adenocarcinoma 22.5 6 17022010 (3), 18477251 (1), 17868774 (1)
    nsclc 20.8 2 16314486 (1), 15386340 (1)
    adenoma 17.9 1 20086108 (1)
    rheumatoid arthritis 16.5 1 14558087 (1)
    colorectal cancer 13.4 6 12818365 (1), 16495511 (1), 19412621 (1), 16538022 (1)
    arthritis 12.6 3 15910650 (2), 11067848 (1)
    cancer 11.6 12 18477251 (3), 11555570 (1), 16533161 (1), 17546626 (1) (see all 7)
    tumors 11 8 20042640 (1), 15629771 (1), 18477251 (1), 18980437 (1) (see all 8)
    cancer lung 10.3 2 17374734 (2)

    Genetic Association Database (GAD): PTGES
    Human Genome Epidemiology (HuGE) Navigator: PTGES (19 documents)

    Export disorders for PTGES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGES gene, integrated from 9 sources (see all 226):
    (articles sorted by number of sources associating them with PTGES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A model for p53-induced apoptosis. (PubMed id 9305847)1, 2, 3 Polyak K....Vogelstein B. (1997)
    2. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4, 9 Lemaitre R.N....Psaty B.M. (2008)
    3. Human glutathione dependent prostaglandin E synthase: gene structure and regulation. (PubMed id 10760517)1, 2, 9 Forsberg L.... Jakobsson P.J. (2000)
    4. Genetic variation in prostaglandin E2 synthesis and s ignaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PubMed id 20086108)1, 4, 9 Poole E.M....Ulrich C.M. (2010)
    5. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PubMed id 19276290)1, 4, 9 Abraham J.E....Pharoah P.D. (2009)
    6. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PubMed id 18038187)1, 4, 9 Hoeft B....Nieters A. (2008)
    7. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)1, 4, 9 Iwai N....Shioji K. (2004)
    8. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. (PubMed id 10377395)1, 2, 9 Jakobsson P.-J.... Samuelsson B. (1999)
    9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9536 HGNC: 9599 AceView: PTGES Ensembl:ENSG00000148344 euGenes: HUgn9536
    ECgene: PTGES Kegg: 9536 H-InvDB: PTGES

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGES Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTGES Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTGES gene:
    Search GeneIP for patents involving PTGES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PTGES  
     OriGene qPCR primer pairs and template standards for PTGES   OriGene Protein Over-expression Lysate for PTGES  
     OriGene MassSpec something-or-other for PTGES   OriGene clones in human, mouse for PTGES  
     OriGene qSTAR qPCR primer pairs in human, mouse for PTGES   OriGene Purified Protein for PTGES  
     OriGene ORF clones in mouse, rat for PTGES   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PTGES   OriGene Custom Protein Services for PTGES  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PTGES
     QIAGEN SeqTarget long-range PCR primers for resequencing PTGES
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGES
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGES
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGES
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGES
     GenScript Custom Purified and Recombinant Proteins Services for PTGES GenScript cDNA clones with any tag delivered in your preferred vector for PTGES
     GenScript Custom Assay Services for PTGES GenScript Custom Superior Antibodies Services for PTGES
     GenScript Custom overexpressing Cell Line Services for PTGES CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PTGES promoter
     Search Chromatin IP Primers for PTGES
     RT2 qPCR Primer Assay in human, mouse, rat PTGES
     GNC Network for PTGES
     SABiosciences PCR Arrays including human, mouse, rat PTGES
     Search Tocris compounds for PTGES
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PTGES
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PTGES antibodies
     PTGES proteins
     PTGES lysates
     Antibodies for PTGES
     See all of Abcam's Antibodies, Kits and Proteins for PTGES
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PTGES
     Antibodies for PTGES
     ELISAs for PTGES
     CLIAs for PTGES
     Search LifeMap BioReagents cell lines for PTGES
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGES
     SwitchGear 3'UTR luciferase reporter plasmids for PTGES
     SwitchGear Promoter luciferase reporter plasmids for PTGES
     ThermoFisher Antibodies for PTGES
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGES
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGES
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGES
    Customized:
     lentivirus for stable overexpression of PTGES
     lentivirus expression plasmids for stable overexpression of PTGES
     adenovirus for overexpression of PTGES
     LSBio Antibodies in human, mouse, rat for PTGES
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PTGES gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4