Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTGES Gene

Aliases for PTGES Gene

  • Prostaglandin E Synthase 2 3 5
  • Microsomal Glutathione S-Transferase 1-Like 1 2 3 4
  • Tumor Protein P53 Inducible Protein 12 2 3
  • Microsomal Prostaglandin E Synthase-1 2 3
  • Glutathione S-Transferase 1-Like 1 2 3
  • P53-Induced Gene 12 Protein 3 4
  • MGST1-Like 1 2 3
  • MGST1-L1 3 4
  • MPGES-1 3 4
  • MGST1L1 3 4
  • PIG12 3 4
  • PGES 3 4
  • Microsomal Prostaglandin E Synthase 1 4
  • P53-Induced Apoptosis Protein 12 3
  • P53-Induced Gene 12 2
  • EC 5.3.99.3 4
  • MGST-IV 3
  • TP53I12 3
  • PP1294 3
  • MPGES1 4
  • MPGES 3
  • PP102 3

External Ids for PTGES Gene

Previous HGNC Symbols for PTGES Gene

  • MGST1L1

Previous GeneCards Identifiers for PTGES Gene

  • GC09M123615
  • GC09M124147
  • GC09M125954
  • GC09M127876
  • GC09M129580
  • GC09M131540
  • GC09M132500
  • GC09M102099

Summaries for PTGES Gene

Entrez Gene Summary for PTGES Gene

  • The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGES Gene

PTGES (Prostaglandin E Synthase) is a Protein Coding gene. Diseases associated with PTGES include Arthritis and Necrotizing Ulcerative Gingivitis. Among its related pathways are Metabolism and Eicosanoid Synthesis. GO annotations related to this gene include glutathione binding and prostaglandin-E synthase activity. An important paralog of this gene is MGST1.

UniProtKB/Swiss-Prot for PTGES Gene

  • Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).

Gene Wiki entry for PTGES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES Gene

Genomics for PTGES Gene

Regulatory Elements for PTGES Gene

Enhancers for PTGES Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F129748 1.1 FANTOM5 ENCODE 20.5 +26.1 26083 5.4 BRCA1 ZNF121 ZNF143 FOS SP3 REST SMARCB1 ZNF623 MAFF SMARCA4 PTGES LOC101929314 SPOUT1 USP20 TOR1A GC09M129739
GH09F129724 1.3 FANTOM5 Ensembl ENCODE 12.3 +51.2 51194 2.7 BRCA1 ZNF2 RAD21 RFX5 GLIS2 ZNF143 ZMIZ1 DEK ZHX1 ZNF263 PRRX2 PTGES TOR1B ASB6 ENSG00000234789 TOR1A C9orf78 USP20 C9orf50 PRRX2-AS1
GH09F129693 1.3 FANTOM5 Ensembl ENCODE 11.8 +77.7 77733 11.8 HDGF ATF1 SIN3A YBX1 GLIS2 ZNF207 FOS ZNF263 SP3 SMARCA4 PRRX2 ASB6 ENSG00000234789 PTGES TOR1A C9orf78 USP20 C9orf50 PIR44517 PRRX2-AS1
GH09F129742 1.1 FANTOM5 ENCODE 7.5 +33.7 33717 1.5 HDAC1 LEF1 ATF1 PKNOX1 ESRRA TBL1XR1 CCNT2 ZNF316 ZSCAN29 CREM TOR1B ASB6 ENSG00000234789 PTGES GC09M129739
GH09F129760 1.3 Ensembl ENCODE 6.5 +14.8 14847 3.1 PKNOX1 ZNF48 GTF3C2 ZNF121 FOS MEF2D SMARCA4 STAT3 HMBOX1 KDM1A LOC101929314 PTGES GC09M129739
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PTGES on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PTGES gene promoter:

Genomic Location for PTGES Gene

Chromosome:
9
Start:
129,738,331 bp from pter
End:
129,777,327 bp from pter
Size:
38,997 bases
Orientation:
Minus strand

Genomic View for PTGES Gene

Genes around PTGES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES Gene

Proteins for PTGES Gene

  • Protein details for PTGES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14684-PTGES_HUMAN
    Recommended name:
    Prostaglandin E synthase
    Protein Accession:
    O14684
    Secondary Accessions:
    • O14900
    • Q5SZC0

    Protein attributes for PTGES Gene

    Size:
    152 amino acids
    Molecular mass:
    17102 Da
    Cofactor:
    Name=glutathione; Xref=ChEBI:CHEBI:57925;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for PTGES Gene

neXtProt entry for PTGES Gene

Post-translational modifications for PTGES Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGES Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PTGES

No data available for DME Specific Peptides for PTGES Gene

Domains & Families for PTGES Gene

Gene Families for PTGES Gene

IUPHAR :

Suggested Antigen Peptide Sequences for PTGES Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14684

UniProtKB/Swiss-Prot:

PTGES_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with PTGES: view

Function for PTGES Gene

Molecular function for PTGES Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Enzyme Numbers (IUBMB) for PTGES Gene

Gene Ontology (GO) - Molecular Function for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016853 isomerase activity IEA --
GO:0043295 glutathione binding IDA 18682561
GO:0050220 prostaglandin-E synthase activity IDA 18682561
genes like me logo Genes that share ontologies with PTGES: view
genes like me logo Genes that share phenotypes with PTGES: view

Animal Models for PTGES Gene

MGI Knock Outs for PTGES:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGES

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGES

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGES Gene

Localization for PTGES Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGES Gene COMPARTMENTS Subcellular localization image for PTGES gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
extracellular 3
nucleus 3
peroxisome 2
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005641 nuclear envelope lumen IEA --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,TAS 10377395
GO:0016021 integral component of membrane IEA,IDA 18682561
genes like me logo Genes that share ontologies with PTGES: view

Pathways & Interactions for PTGES Gene

genes like me logo Genes that share pathways with PTGES: view

Gene Ontology (GO) - Biological Process for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 18682561
GO:0002526 acute inflammatory response IEA --
GO:0002544 chronic inflammatory response IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with PTGES: view

No data available for SIGNOR curated interactions for PTGES Gene

Drugs & Compounds for PTGES Gene

(14) Drugs for PTGES Gene - From: PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor Selective cyclooxygenase-2 (COX-2) inhibitor 435
Flurbiprofen Approved, Investigational Pharma Channel blocker 47
Suprofen Approved, Withdrawn Pharma 0
Glutathione Approved Nutra 0
Mesalamine Pharma 160

(14) Additional Compounds for PTGES Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,13E)-(15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dienoate
42935-17-1

(3) ApexBio Compounds for PTGES Gene

Compound Action Cas Number
Flurbiprofen 5104-49-4
Mesalamine 89-57-6
Suprofen 40828-46-4
genes like me logo Genes that share compounds with PTGES: view

Transcripts for PTGES Gene

mRNA/cDNA for PTGES Gene

Unigene Clusters for PTGES Gene

Prostaglandin E synthase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGES

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES Gene

No ASD Table

Relevant External Links for PTGES Gene

GeneLoc Exon Structure for
PTGES
ECgene alternative splicing isoforms for
PTGES

Expression for PTGES Gene

mRNA expression in normal human tissues for PTGES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGES Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.6) and Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for PTGES Gene

This gene is overexpressed in Nasal epithelium (60.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTGES Gene



NURSA nuclear receptor signaling pathways regulating expression of PTGES Gene:

PTGES

SOURCE GeneReport for Unigene cluster for PTGES Gene:

Hs.146688
genes like me logo Genes that share expression patterns with PTGES: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PTGES Gene

Orthologs for PTGES Gene

This gene was present in the common ancestor of animals.

Orthologs for PTGES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGES 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia PTGES 34 35
  • 88.81 (n)
cow
(Bos Taurus)
Mammalia PTGES 34 35
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Ptges 34 16 35
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Ptges 34
  • 82.46 (n)
oppossum
(Monodelphis domestica)
Mammalia PTGES 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGES 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGES 34 35
  • 74.13 (n)
lizard
(Anolis carolinensis)
Reptilia PTGES 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptges 34
  • 69.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19439 34
zebrafish
(Danio rerio)
Actinopterygii ptges 34 35
  • 66.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mgstl 35
  • 34 (a)
ManyToMany
CG33178 35
  • 30 (a)
ManyToMany
CG33177 35
  • 28 (a)
ManyToMany
Species where no ortholog for PTGES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGES Gene

ENSEMBL:
Gene Tree for PTGES (if available)
TreeFam:
Gene Tree for PTGES (if available)

Paralogs for PTGES Gene

Paralogs for PTGES Gene

(1) SIMAP similar genes for PTGES Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTGES: view

Variants for PTGES Gene

Sequence variations from dbSNP and Humsavar for PTGES Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114996 -- 129,759,070(+) GCCAC(C/T)GTGCC intron-variant
rs10118377 -- 129,761,581(+) CTAGC(A/G)TGGTG intron-variant
rs10119273 -- 129,739,627(+) GGGCC(A/G)CTTCC reference, missense
rs10121317 -- 129,752,554(+) GAAGC(C/T)ACCAG intron-variant
rs10125406 -- 129,762,554(+) AGTAG(A/G)GACGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGES Gene

Variant ID Type Subtype PubMed ID
dgv1511e214 CNV gain 21293372
esv3621839 CNV loss 21293372
nsv1046477 CNV gain 25217958
nsv6728 CNV deletion 18451855

Variation tolerance for PTGES Gene

Gene Damage Index Score: 1.35; 26.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGES Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGES Gene

Disorders for PTGES Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTGES Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthritis
  • inflammatory disorder of joint
necrotizing ulcerative gingivitis
  • acute necrotising ulcerative gingivitis
amphetamine abuse
- elite association - COSMIC cancer census association via MalaCards
Search PTGES in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTGES

Genetic Association Database (GAD)
PTGES
Human Genome Epidemiology (HuGE) Navigator
PTGES
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGES
genes like me logo Genes that share disorders with PTGES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGES Gene

Publications for PTGES Gene

  1. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole E.M. … Ulrich C.M. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 22 46 64
  2. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre R.N. … Psaty B.M. (Atherosclerosis 2009) 3 22 46 64
  3. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PMID: 19276290) Abraham J.E. … Pharoah P.D. (Clin. Cancer Res. 2009) 3 22 46 64
  4. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PMID: 18038187) Hoeft B. … Nieters A. (Cancer Causes Control 2008) 3 22 46 64
  5. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PMID: 15167446) Iwai N. … Shioji K. (J. Hypertens. 2004) 3 22 46 64

Products for PTGES Gene

Sources for PTGES Gene

Content
Loading form....