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Aliases for PTGER4 Gene

Aliases for PTGER4 Gene

  • Prostaglandin E Receptor 4 2 3 5
  • Prostaglandin E Receptor 4 (Subtype EP4) 2 3
  • PGE2 Receptor EP4 Subtype 3 4
  • PGE Receptor EP4 Subtype 3 4
  • Prostanoid EP4 Receptor 3 4
  • PGE Receptor, EP4 Subtype 3
  • PTGER2 4
  • EP4R 3
  • EP4 3

External Ids for PTGER4 Gene

Previous GeneCards Identifiers for PTGER4 Gene

  • GC05P040986
  • GC05P041772
  • GC05P040680
  • GC05P040725
  • GC05P040715
  • GC05P040632

Summaries for PTGER4 Gene

Entrez Gene Summary for PTGER4 Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGER4 Gene

PTGER4 (Prostaglandin E Receptor 4) is a Protein Coding gene. Diseases associated with PTGER4 include Malignant Epithelial Mesothelioma and Epididymis Cancer. Among its related pathways are Peptide ligand-binding receptors and Eicosanoid ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGER4 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Tocris Summary for PTGER4 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER4 Gene

Genomics for PTGER4 Gene

Regulatory Elements for PTGER4 Gene

Enhancers for PTGER4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTGER4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGER4 Gene

Chromosome:
5
Start:
40,679,498 bp from pter
End:
40,741,764 bp from pter
Size:
62,267 bases
Orientation:
Plus strand

Genomic View for PTGER4 Gene

Genes around PTGER4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER4 Gene

Proteins for PTGER4 Gene

  • Protein details for PTGER4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35408-PE2R4_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP4 subtype
    Protein Accession:
    P35408
    Secondary Accessions:
    • Q3MJ87

    Protein attributes for PTGER4 Gene

    Size:
    488 amino acids
    Molecular mass:
    53119 Da
    Quaternary structure:
    • Interacts with FEM1A.

neXtProt entry for PTGER4 Gene

Proteomics data for PTGER4 Gene at MOPED

Post-translational modifications for PTGER4 Gene

  • Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
  • Ubiquitination at Lys 468
  • Glycosylation at Asn 7
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGER4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGER4 Gene

Domains & Families for PTGER4 Gene

Gene Families for PTGER4 Gene

Suggested Antigen Peptide Sequences for PTGER4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35408

UniProtKB/Swiss-Prot:

PE2R4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER4: view

Function for PTGER4 Gene

Molecular function for PTGER4 Gene

GENATLAS Biochemistry:
prostaglandin E4 receptor,subtype EP4,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
genes like me logo Genes that share phenotypes with PTGER4: view

Animal Models for PTGER4 Gene

MGI Knock Outs for PTGER4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER4 Gene

Localization for PTGER4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER4 Gene COMPARTMENTS Subcellular localization image for PTGER4 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytoskeleton 2
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for PTGER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with PTGER4: view

Pathways & Interactions for PTGER4 Gene

genes like me logo Genes that share pathways with PTGER4: view

Interacting Proteins for PTGER4 Gene

Gene Ontology (GO) - Biological Process for PTGER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002792 negative regulation of peptide secretion IEA --
GO:0006955 immune response IEP 8862514
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007254 JNK cascade ISS --
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with PTGER4: view

No data available for SIGNOR curated interactions for PTGER4 Gene

Drugs & Compounds for PTGER4 Gene

(53) Drugs for PTGER4 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dinoprostone Approved Pharma antagonist, Target, agonist Major endogenous prostanoid 78
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 77
Misoprostol Approved Pharma Target, agonist 268
Treprostinil Approved, Investigational Pharma Full agonist, Agonist, agonist 77
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor Selective cyclooxygenase-2 (COX-2) inhibitor 423

(24) Additional Compounds for PTGER4 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PGF<sub>2alpha</sub>
Full agonist, Agonist
(+-)-Cloprostenol sodium salt
55028-72-3
U 46619
56985-40-1

(5) Tocris Compounds for PTGER4 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1
genes like me logo Genes that share compounds with PTGER4: view

Transcripts for PTGER4 Gene

Unigene Clusters for PTGER4 Gene

Prostaglandin E receptor 4 (subtype EP4):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for PTGER4 Gene

GeneLoc Exon Structure for
PTGER4
ECgene alternative splicing isoforms for
PTGER4

Expression for PTGER4 Gene

mRNA expression in normal human tissues for PTGER4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER4 Gene

This gene is overexpressed in Whole Blood (x4.8) and Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for PTGER4 Gene

This gene is overexpressed in Vitreous humor (38.1), Cardia (22.7), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGER4 Gene



SOURCE GeneReport for Unigene cluster for PTGER4 Gene Hs.199248

mRNA Expression by UniProt/SwissProt for PTGER4 Gene

P35408-PE2R4_HUMAN
Tissue specificity: High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
genes like me logo Genes that share expression patterns with PTGER4: view

Protein tissue co-expression partners for PTGER4 Gene

Primer Products

Orthologs for PTGER4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGER4 35
  • 88.73 (n)
  • 90.52 (a)
PTGER4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGER4 35
  • 90.1 (n)
  • 91.55 (a)
PTGER4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptger4 35
  • 86.46 (n)
  • 88.66 (a)
Ptger4 16
Ptger4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTGER4 35
  • 99.39 (n)
  • 99.39 (a)
PTGER4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptger4 35
  • 86.6 (n)
  • 89.07 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGER4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGER4 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGER4 35
  • 74.59 (n)
  • 79.82 (a)
EP4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER4 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger4 35
  • 68.47 (n)
  • 70.93 (a)
zebrafish
(Danio rerio)
Actinopterygii ptger4b 35
  • 63.35 (n)
  • 63.05 (a)
ptger4a 36
  • 67 (a)
OneToMany
ptger4b 36
  • 56 (a)
OneToMany
Species with no ortholog for PTGER4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER4 Gene

ENSEMBL:
Gene Tree for PTGER4 (if available)
TreeFam:
Gene Tree for PTGER4 (if available)

Paralogs for PTGER4 Gene

Paralogs for PTGER4 Gene

(4) SIMAP similar genes for PTGER4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PTGER4 Gene

genes like me logo Genes that share paralogs with PTGER4: view

Variants for PTGER4 Gene

Sequence variations from dbSNP and Humsavar for PTGER4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs6862446 -- 40,696,982(+) agaga(A/G)agaga intron-variant, downstream-variant-500B
rs6862453 -- 40,696,990(+) agaga(A/G)agaga intron-variant, downstream-variant-500B
rs6862979 -- 40,697,044(+) gaaag(A/G)aagga intron-variant, downstream-variant-500B
rs6867618 -- 40,697,594(+) aaaaa(A/C)aaaaa intron-variant
rs6869759 -- 40,685,745(+) CTGCA(A/C)ATGAA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTGER4 Gene

Variant ID Type Subtype PubMed ID
nsv880993 CNV Loss 21882294
nsv880539 CNV Loss 21882294

Variation tolerance for PTGER4 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGER4 Gene

Human Gene Mutation Database (HGMD)
PTGER4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER4 Gene

Disorders for PTGER4 Gene

MalaCards: The human disease database

(31) MalaCards diseases for PTGER4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant epithelial mesothelioma
  • epithelioid mesothelioma, malignant
epididymis cancer
  • malignant epididymal tumor
epididymis adenocarcinoma
  • adenocarcinoma of the epididymis
papillary thymic adenocarcinoma
  • papillary carcinoma of the thymus
lymphocytic colitis
  • colitis, lymphocytic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTGER4

Genetic Association Database (GAD)
PTGER4
Human Genome Epidemiology (HuGE) Navigator
PTGER4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGER4
genes like me logo Genes that share disorders with PTGER4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER4 Gene

Publications for PTGER4 Gene

  1. The structure of the prostaglandin EP4 receptor gene and related pseudogenes. (PMID: 8661119) Foord S.M. … Lee M.G. (Genomics 1996) 2 3 4 23 67
  2. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole E.M. … Ulrich C.M. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 23
  3. Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. (PMID: 20145136) Terada N. … Ogawa O. (Cancer Res. 2010) 3 23
  4. Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. (PMID: 20353998) Kim J.I. … Daaka Y. (Mol. Cancer Res. 2010) 3 23
  5. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. (PMID: 19407222) Banu S.K. … Arosh J.A. (Mol. Endocrinol. 2009) 3 23

Products for PTGER4 Gene

Sources for PTGER4 Gene

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