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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGER3 Gene

protein-coding   GIFtS: 68
GCID: GC01M071318

Prostaglandin E Receptor 3 (Subtype EP3)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Prostaglandin E Receptor 3 (Subtype EP3)1 2     EP3-IV2
Prostanoid EP3 Receptor2 3     EP3e2
PGE2-R2 3     PGE Receptor, EP3 Subtype2
PGE2 Receptor EP3 Subtype2 3     Prostaglandin E Receotor EP3 Subtype 3 Isoform2
EP32 5     Prostaglandin E2 Receptor EP3 Subtype2
EP3-I2     Prostaglandin Receptor (PGE-2)2
EP3-II2     PGE Receptor EP3 Subtype3
EP3-III2     

External Ids:    HGNC: 95951   Entrez Gene: 57332   Ensembl: ENSG000000506287   OMIM: 1768065   UniProtKB: P431153   
ORGUL members:         
NONCODE14:n408169 n408171 n338001      

Export aliases for PTGER3 gene to outside databases

Previous GC identifers: GC01M071442 GC01M070241 GC01M070702 GC01M070688 GC01M070687 GC01M071030 GC01M069428


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGER3 Gene:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four
receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve
digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse
counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever
generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Aug 2009)

GeneCards Summary for PTGER3 Gene: 
PTGER3 (prostaglandin E receptor 3 (subtype EP3)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PTGER3 include mooren's ulcer, and conjunctivochalasis, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Eicosanoid ligand-binding receptors. GO annotations related to this gene include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115
Function: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid
secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and
water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can
couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular
calcium. The various isoforms have identical ligand binding properties but can interact with different second
messenger systems (By similarity)

summary for PTGER3 Gene:
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of
prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle
contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory
receptor that prevents smooth muscle relaxation.

Gene Wiki entry for PTGER3 (Prostaglandin E receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGER3 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGER3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGER3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.2   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.2

PTGER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGER3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M071318:  view genomic region     (about GC identifiers)

Start:
71,318,036 bp from pter      End:
71,513,491 bp from pter
Size:
195,456 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PTGER3

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115 (See protein sequence)
Recommended Name: Prostaglandin E2 receptor EP3 subtype  
Size: 390 amino acids; 43310 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B0AZN4 B5BUP5 O00326 Q12943 Q12944 Q12945 Q16546
Alternative splicing: 7 isoforms:  P43115-1   P43115-2   P43115-3   P43115-4   P43115-5   P43115-6   P43115-7   (Known as EP3F in PubMed:8075855)

Explore the universe of human proteins at neXtProt for PTGER3: NX_P43115

Explore proteomics data for PTGER3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43115

  • PTGER3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGER3 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001119516.1  NP_942007.1  NP_942008.1  NP_942009.1  NP_942010.1  NP_942011.1  NP_942012.1  

    ENSEMBL proteins: 
     ENSP00000359969   ENSP00000423561   ENSP00000421583   ENSP00000424340   ENSP00000418073  
     ENSP00000349003   ENSP00000302313   ENSP00000359962   ENSP00000359970   ENSP00000346624  
     ENSP00000280208   ENSP00000401423  
    Reactome Protein details: P43115
    Human Recombinant Protein Products for PTGER3: 
    EMD Millipore Purified and/or Recombinant PTGER3 Protein
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    Novus Biologicals PTGER3 Proteins
    Novus Biologicals PTGER3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS10336471
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8307176
    GO:0016021integral to membrane NAS9073510

    PTGER3 for ontologies           About GeneDecksing



    PTGER3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTGR: GPCR / Class A : Prostanoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: EP3 receptor 
    Prostanoid receptors

    5/6 InterPro protein domains (see all 6):
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008365 Prostanoid_rcpt
     IPR000265 Prostglndn_EP3_rcpt
     IPR001481 EP3_rcpt_2
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P43115

    ProtoNet protein and cluster: P43115

    3 Blocks protein domains:
    IPB000265 Prostanoid EP3 receptor signature
    IPB001244 Prostaglandin receptor signature
    IPB001481 Prostanoid EP3 receptor type 2 signature


    UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115
    Similarity: Belongs to the G-protein coupled receptor 1 family


    PTGER3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PE2R3_HUMAN, P43115
    Function: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid
    secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and
    water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can
    couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular
    calcium. The various isoforms have identical ligand binding properties but can interact with different second
    messenger systems (By similarity)

         Genatlas biochemistry entry for PTGER3:
    prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS10336471
    GO:0004930G-protein coupled receptor activity ----
    GO:0004957prostaglandin E receptor activity NAS9073510
    GO:0005515protein binding ----
         
    PTGER3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PTGER3:
     Increased circadian period len 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ptger3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  renal/urinary system 

    PTGER3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ptger3tm1Cof for PTGER3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGER3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGER3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGER3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGER3 

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGER3 (see all 43):
    hsa-miR-4291 hsa-miR-106a hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-128 hsa-miR-183* hsa-miR-93 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidPTGER3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 7): PTGER3 (NM_001126044)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGER3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTGER3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Prostanoid ligand receptors
    Prostanoid ligand receptors0.60
    Small Ligand GPCRs0.40
    Eicosanoid ligand-binding receptors0.60
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4PKA activation in glucagon signalling
    Neurophysiological process PGE2-induced pain processing0.44
    5Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PTGER3
        Neurophysiological process PGE2-induced pain processing


    1 GeneGo (Thomson Reuters) Pathway for PTGER3
        Neurophysiological process PGE2-induced pain processing

    3 BioSystems Pathways for PTGER3
        GPCRs, Class A Rhodopsin-like
    Prostaglandin Synthesis and Regulation
    Small Ligand GPCRs

    5/8        Reactome Pathways for PTGER3 (see all 8)
        GPCR downstream signaling
    Eicosanoid ligand-binding receptors
    Prostanoid ligand receptors
    Signal Transduction
    Signaling by GPCR

    1 PharmGKB Pathway for PTGER3
        Celecoxib Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for PTGER3):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    PTGER3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/149 Interacting proteins for PTGER3 (P431153 ENSP000003490034) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTGER1P349953, ENSP000002925134I2D: score=1 STRING: ENSP00000292513
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY9ENSP000002940164STRING: ENSP00000294016
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001660fever generation ----
    GO:0006351transcription, DNA-dependent TAS10336471
    GO:0007186G-protein coupled receptor signaling pathway TAS8307176
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway ----

    PTGER3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGER3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PTGER3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IloprostProstacyclin (PGI2) analog[78919-13-8]
    L-798,106 Potent and highly selective EP3 antagonist[244101-02-8]
    U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]
    Prostaglandin E2Major endogenous prostanoid[363-24-6]
    L-161,982 Selective EP4 receptor antagonist[147776-06-5]

    3 HMDB Compounds for PTGER3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for PTGER3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Misoprostol-- 59122-46-2targetagonist16039053 18472336 11602631 12097143 9313928
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6targetagonist18715952 19788928 20599704 17329241
    Bimatoprost-- 155206-00-1targetagonist19232013 16877408 14733708

    10/23 IUPHAR Ligands for PTGER3 (EP3 receptor) (see all 23)    About this table 
    LigandTypeActionAffinityPubmed IDs
    DG-041
    AntagonistAntagonist10.118632791
    M&B 28767
    AgonistFull agonist9.910634944
    L-798,106
    AntagonistAntagonist9.6818632791
    PGE2
    AgonistFull agonist8.2 - 9.516604093 10634944
    [3H]PGE2
    AgonistFull agonist8.2 - 9.516604093 10634944
    sulprostone
    AgonistFull agonist9.4610634944
    L-826266 (sodium salt)
    AntagonistAntagonist9.111504634
    cloprostenol
    AgonistFull agonist8.410634944
    GR 63799
    AgonistFull agonist8.310634944
    misoprostol (free acid form)
    AgonistFull agonist8.110634944

    10/27 Novoseek inferred chemical compound relationships for PTGER3 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butaprost 96.1 9 9530435 (1), 15888106 (1), 18932216 (1), 8149238 (1) (see all 8)
    sulprostone 95 23 9530435 (2), 9863659 (2), 7532011 (1), 10697805 (1) (see all 16)
    gr 63799x 92.7 4 9530435 (1), 8641211 (1)
    11-deoxy-pge1 92.6 3 12753465 (1), 16512814 (1), 9196397 (1)
    pge2 90 161 15331179 (5), 19212690 (4), 11997037 (4), 19416642 (3) (see all 83)
    prostaglandin 83.6 30 8396726 (1), 7532011 (1), 8908618 (1), 9065782 (1) (see all 20)
    ah23848 77.9 1 9888433 (1)
    17-phenyl-trinor-pge2 74.4 3 7970215 (1), 20381634 (1)
    pgd2 70.1 2 18005048 (1), 9730918 (1)
    iloprost 68.8 1 17690331 (1)

    1 PharmGKB related drug/compound annotation for PTGER3 gene    About this table
    Drug/compound PharmGKB Annotation
    Ace Inhibitors, PlainCA  

    Search CenterWatch for drugs/clinical trials and news about PTGER3 / PE2R3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PTGER3 gene (11 alternative transcripts): 
    NM_001126044.1  NM_198714.1  NM_198715.2  NM_198716.1  NM_198717.1  NM_198718.1  NM_198719.1  NM_000957.2  
    NM_198712.2  NM_198713.1  NM_198720.1  

    Unigene Cluster for PTGER3:

    Prostaglandin E receptor 3 (subtype EP3)
    Hs.445000  [show with all ESTs]
    Unigene Representative Sequence: NM_198715
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370931 ENST00000497146(uc001dfi.1) ENST00000479353(uc001dfj.1 uc009wbm.1)
    ENST00000361210(uc001dfh.1) ENST00000460330 ENST00000356595 ENST00000306666(uc001dfp.1)
    ENST00000370924(uc001dfq.3) ENST00000370932(uc001dfl.1) ENST00000354608(uc001dfm.1 uc001dfn.3 uc009wbn.2)
    ENST00000351052(uc001dfg.1 uc001dfk.1) ENST00000414819(uc009wbo.3 uc001dfo.3)

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    SwitchGear 3'UTR luciferase reporter plasmidPTGER3 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGER3
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    Additional mRNA sequence: 

    AB451481.1 AK290634.1 AK315825.1 AL050227.1 AY387856.1 AY429108.1 BC024229.1 BC118578.1 
    BC118659.1 D38297.1 D38298.1 D38299.1 D38300.1 D38301.1 D86097.1 D86098.1 
    EF534325.1 L26976.1 L27488.1 L27489.1 L27490.1 NR_028292.1 NR_028293.1 NR_028294.1 
    S68874.1 S69200.1 S69326.1 U13214.1 U13215.1 U13217.1 U13218.1 X83857.1 
    X83858.1 X83859.1 X83861.1 X83862.1 X83863.1 

    13 DOTS entries:

    DT.86854693  DT.86854689  DT.445098  DT.86854695  DT.411095  DT.86854688  DT.100748959  DT.100748960 
    DT.121367365  DT.92426581  DT.121367374  DT.306817  DT.92426580 

    24/125 AceView cDNA sequences (see all 125):

    D38301 AL700353 AI927885 BQ006977 BX104537 BE501470 AL707597 D38298 
    S68875 NM_198719 AA058938 AI273491 NM_198712 H22163 D38297 AA025413 
    BQ716726 L32660 BG742211 AA406418 D86098 BF475870 Z40794 Z45064 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -     -           -     -           -                     
    SP2:                          -     -     -           -     -     -                           
    SP3:                          -           -                                                   
    SP4:                          -     -     -     -     -     -           -                     
    SP5:                          -                                                               


    ECgene alternative splicing isoforms for PTGER3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGER3 expression in normal human tissues (normalized intensities)      PTGER3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGTACT
    PTGER3 Expression
    About this image


    PTGER3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Body Subcutaneous White Adipose
             adipose tissue   
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Conventional Dendritic Cells II Spleen
             Mast-like cells ( Generation of hematopoietic progenitor cells and mast cells )
     
     Uterus (Reproductive System)
             myometrium   
     
     Breast (NULL)
             breast stroma   
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See PTGER3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGER3

    SOURCE GeneReport for Unigene cluster: Hs.445000

    UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115
    Tissue specificity: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and
    pulmonary vessels

        SABiosciences Expression via Pathway-Focused PCR Array including PTGER3: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PTGER3 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptger31 , 5 prostaglandin E receptor 3 (subtype EP3)1, 5 83.93(n)1
    86.53(a)1
      3 (81.32 cM)5
    192181  NM_011196.21  NP_035326.21 
     1575668925 
    chicken
    (Gallus gallus)
    Aves PTGER31 prostaglandin E receptor 3 (subtype EP3) 77.11(n)
    74.68(a)
      429116  NM_001040468.1  NP_001035558.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTGER36
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343194.1(74539-98883)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000005441 prostaglandin E2 receptor EP3 subtype-like 62.31(n)
    61.39(a)
      100000544  XM_001340689.4  XP_001340725.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74976
    --
    19(a)
    1 → many
    3L(17626549-17630975)


    ENSEMBL Gene Tree for PTGER3 (if available)
    TreeFam Gene Tree for PTGER3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGER3 gene
    PTGER12  PTGDR2  PTGER42  PTGFR2  PTGER22  TBXA2R2  PTGIR2  
    10 SIMAP similar genes for PTGER3 using alignment to 7 protein entries:     PE2R3_HUMAN (see all proteins):
    EP3 prostanoid receptor EP3-I    EP3-III    EP3-IV    EP3-VI    EP3-V    EP3f
    EP3e    EP3-I    PTGFR    TBXA2R

    PTGER3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3930 SNPs in PTGER3 are shown (see all 3930)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679877331,2
    C--69469938(+) TTACA-/TGAG  
            
    TAAGA
    6 -- int10--------
    rs792260921,2
    C--69469939(+) TACATA/GAGTAA 6 -- int10--------
    rs61432711,2
    C--69477221(+) CAAGTGAGT/-  
            
    ATGTA
    6 -- int11Minor allele frequency- -:0.50NA 2
    rs799820011,2
    C--69487008(+) CTTGC-/AAAAAGA 6 -- int10--------
    rs340174051,2
    C--69488471(-) AATTT-/TGTAAC 6 -- int10--------
    rs2019709551,2
    --69497957(+) AAAAA-/TAAATA 6 -- int10--------
    rs358873221,2
    C--69499528(+) TTTTT-/T/TTT 
            
    GGCTC
    9 -- int1 cds10--------
    rs1435486641,2
    C--69504440(+) ATATT-/TATATAT 6 -- int10--------
    rs1491338401,2
    C--69505178(+) CAGAT-/ACACACA 6 -- int10--------
    rs589317881,2
    C--69511985(+) ATATA-/AA/   
       T
    /TAT
    AATAT
    9 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for PTGER3 (71318036 - 71513491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PTGER3 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672048CNV Deletion23128226
    esv994407CNV Insertion20482838
    nsv871222CNV Loss21882294
    nsv871812CNV Loss21882294
    nsv870734CNV Loss21882294
    nsv871141CNV Loss21882294
    nsv871313CNV Loss21882294
    nsv516212CNV Loss19592680
    nsv871242CNV Loss21882294
    dgv238n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176806    OMIM disorders: --

    20/38 diseases for PTGER3 (see all 38):    About MalaCards
    mooren's ulcer    conjunctivochalasis    allergic conjunctivitis    stevens-johnson syndrome
    endometritis    pulmonary edema    adenomyosis    abdominal aortic aneurysm
    aortic aneurysm    gingivitis    duodenitis    conjunctivitis
    medulloblastoma    essential hypertension    lung adenocarcinoma    pertussis
    periodontitis    oral squamous cell carcinoma    colon cancer    astrocytoma

    2 diseases from the University of Copenhagen DISEASES database for PTGER3:
    Allergic conjunctivitis     Conjunctivochalasis

    PTGER3 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for PTGER3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intestinal polyps 46.8 1 11533709 (1)
    mastocytoma 30.7 3 14577329 (1), 1372606 (1)
    colon cancer 17.4 12 15247185 (8)
    adenocarcinoma lung 12 5 15331179 (2), 11997037 (2)
    atherosclerotic plaque 7.73 3 16020747 (1), 16424787 (1)
    inflammation 3.27 2 20387535 (1)
    tumors 0 7 14751245 (1), 20145019 (1), 20100359 (1), 18715952 (1) (see all 5)
    carcinoma 0 4 19212690 (2)

    Genetic Association Database (GAD): PTGER3
    Human Genome Epidemiology (HuGE) Navigator: PTGER3 (19 documents)

    Export disorders for PTGER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGER3 gene, integrated from 9 sources (see all 269):
    (articles sorted by number of sources associating them with PTGER3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PubMed id 9073510)1, 2, 3, 9 Kotani M....Nakao K. (1997)
    2. Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population. (PubMed id 17877755)1, 4, 9 Park H.W....Cho S.H. (2007)
    3. A new mRNA splice variant coding for the human EP3-I receptor isoform. (PubMed id 18023986)1, 2, 9 Kotelevets L....Norel X. (2007)
    4. Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue- specific distributions. (PubMed id 7476918)1, 2, 9 Kotani M.... Nakao K. (1995)
    5. Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. (PubMed id 7981210)1, 2, 9 An S.... Goetzl E.J. (1994)
    6. Chromosomal localization of the human prostanoid receptor gene family. (PubMed id 7759114)1, 3, 9 Duncan A.M....Adam M. (1995)
    7. Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. (PubMed id 8117308)1, 2, 9 Yang J.... An S. (1994)
    8. Cloning and expression of three isoforms of the human EP3 prostanoid receptor. (PubMed id 8307176)1, 2, 9 Adam M.... Abramovitz M. (1994)
    9. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4, 9 Ryckman K.K....Jacobsson B. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5733 HGNC: 9595 AceView: PTGER3 Ensembl:ENSG00000050628 euGenes: HUgn5733
    ECgene: PTGER3 Kegg: 5733 H-InvDB: PTGER3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGER3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTGER3 gene:
    Search GeneIP for patents involving PTGER3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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