Aliases for PTGER3 Gene
External Ids for PTGER3 Gene
Previous GeneCards Identifiers for PTGER3 Gene
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for PTGER3 Gene
PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3)) is a Protein Coding gene. Diseases associated with PTGER3 include antenatal bartter syndrome and conjunctivochalasis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and prostaglandin E receptor activity. An important paralog of this gene is TBXA2R.
UniProtKB/Swiss-Prot for PTGER3 Gene
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory receptor that prevents smooth muscle relaxation.