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PTGER3 Gene

protein-coding   GIFtS: 66
GCID: GC01M071318

Prostaglandin E Receptor 3 (Subtype EP3)

  See PTGER3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prostaglandin E Receptor 3 (Subtype EP3)1 2     EP3-IV2
Prostanoid EP3 Receptor2 3     EP3e2
PGE2-R2 3     PGE Receptor, EP3 Subtype2
PGE2 Receptor EP3 Subtype2 3     Prostaglandin E Receotor EP3 Subtype 3 Isoform2
EP32 5     Prostaglandin E2 Receptor EP3 Subtype2
EP3-I2     Prostaglandin Receptor (PGE-2)2
EP3-II2     PGE Receptor EP3 Subtype3
EP3-III2     

External Ids:    HGNC: 95951   Entrez Gene: 57332   Ensembl: ENSG000000506287   OMIM: 1768065   UniProtKB: P431153   

Export aliases for PTGER3 gene to outside databases

Previous GC identifers: GC01M071442 GC01M070241 GC01M070702 GC01M070688 GC01M070687 GC01M071030 GC01M069428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PTGER3 Gene:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four
receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve
digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse
counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever
generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Aug 2009)

GeneCards Summary for PTGER3 Gene:
PTGER3 (prostaglandin E receptor 3 (subtype EP3)) is a protein-coding gene. Diseases associated with PTGER3 include conjunctivochalasis, and corneal disease. GO annotations related to this gene include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115
Function: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid
secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and
water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can
couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular
calcium. The various isoforms have identical ligand binding properties but can interact with different second
messenger systems (By similarity)

summary for PTGER3 Gene:
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of
prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle
contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory
receptor that prevents smooth muscle relaxation.

Gene Wiki entry for PTGER3 (Prostaglandin E receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PTGER3 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGER3 promoter sequence
   Search Chromatin IP Primers for PTGER3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PTGER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.2   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.2

PTGER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGER3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M071318:  view genomic region     (about GC identifiers)

Start:
71,318,036 bp from pter      End:
71,513,491 bp from pter
Size:
195,456 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PTGER3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115 (See protein sequence)
Recommended Name: Prostaglandin E2 receptor EP3 subtype  
Size: 390 amino acids; 43310 Da
Secondary accessions: B0AZN4 B5BUP5 O00326 Q12943 Q12944 Q12945 Q16546 Q5CZ59 Q5CZ62 Q5CZ63
Q5CZ64
Alternative splicing: 11 isoforms:  P43115-1   P43115-2   P43115-3   P43115-4   P43115-5   P43115-6   P43115-7   P43115-8   
P43115-9   P43115-10   P43115-11   (Known as EP3F in PubMed:8075855)

Explore the universe of human proteins at neXtProt for PTGER3: NX_P43115

Explore proteomics data for PTGER3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn18, Asn36

  • See PTGER3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001119516.1  NP_942007.1  NP_942008.1  NP_942009.1  NP_942010.1  NP_942011.1  NP_942012.1  

    ENSEMBL proteins: 
     ENSP00000359969   ENSP00000423561   ENSP00000421583   ENSP00000424340   ENSP00000418073  
     ENSP00000349003   ENSP00000302313   ENSP00000359962   ENSP00000359970   ENSP00000346624  
     ENSP00000280208   ENSP00000401423  
    Reactome Protein details: P43115

    PTGER3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PTGER3 

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    Search eBioscience for ELISAs for PTGER3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTGR: GPCR / Class A : Prostanoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: EP3 receptor
    Prostanoid receptors

    Selected InterPro protein domains (see all 6):
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008365 Prostanoid_rcpt
     IPR000265 Prostglndn_EP3_rcpt
     IPR001481 EP3_rcpt_2
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P43115

    ProtoNet protein and cluster: P43115

    3 Blocks protein domains:
    IPB000265 Prostanoid EP3 receptor signature
    IPB001244 Prostaglandin receptor signature
    IPB001481 Prostanoid EP3 receptor type 2 signature


    UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with PTGER3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PE2R3_HUMAN, P43115
    Function: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid
    secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and
    water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can
    couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular
    calcium. The various isoforms have identical ligand binding properties but can interact with different second
    messenger systems (By similarity)

         Genatlas biochemistry entry for PTGER3:
    prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS10336471
    GO:0004930G-protein coupled receptor activity ----
    GO:0004957prostaglandin E receptor activity NAS9073510
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PTGER3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PTGER3:
     Increased circadian period len 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ptger3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  renal/urinary system 

    Find genes that share phenotypes with PTGER3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ptger3tm1Cof for PTGER3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PTGER3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGER3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGER3

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    hsa-miR-4291 hsa-miR-106a hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-128 hsa-miR-183* hsa-miR-93 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidPTGER3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PTGER3

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    GenScript: all cDNA clones in your preferred vector (see all 7): PTGER3 (NM_001126044)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGER3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PE2R3_HUMAN, P43115: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS10336471
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8307176
    GO:0016021integral component of membrane NAS9073510

    Find genes that share ontologies with PTGER3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PTGER3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Eicosanoid ligand-binding receptors
    Eicosanoid ligand-binding receptors0.31
    Prostanoid ligand receptors0.00
    Small Ligand GPCRs0.31
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Ca-dependent events
    Neurophysiological process PGE2 induced pain processing0.38
    5Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation


    Find genes that share SuperPaths with PTGER3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for PTGER3
        Neurophysiological process PGE2-induced pain processing

    3 BioSystems Pathways for PTGER3
        Prostaglandin Synthesis and Regulation
    GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    2 Reactome Pathways for PTGER3
        Prostanoid ligand receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for PTGER3
        Celecoxib Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for PTGER3):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including PTGER3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PTGER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PTGER3 (P431153 ENSP000003490034) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTGER1P349953, ENSP000002925134I2D: score=1 STRING: ENSP00000292513
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY9ENSP000002940164STRING: ENSP00000294016
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001660fever generation ----
    GO:0006351transcription, DNA-templated TAS10336471
    GO:0007186G-protein coupled receptor signaling pathway TAS8307176
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with PTGER3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PTGER3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IloprostProstacyclin (PGI2) analog[78919-13-8]
    L-798,106 Potent and highly selective EP3 antagonist[244101-02-8]
    U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]
    Prostaglandin E2Major endogenous prostanoid[363-24-6]
    L-161,982 Selective EP4 receptor antagonist[147776-06-5]

    3 HMDB Compounds for PTGER3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for PTGER3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Misoprostol-- 59122-46-2targetagonist16039053 18472336 11602631 12097143 9313928
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6targetagonist18715952 19788928 20599704 17329241
    Bimatoprost-- 155206-00-1targetagonist19232013 16877408 14733708

    Selected IUPHAR Ligands for PTGER3 (EP3 receptor) (see all 23)    About this table
    LigandTypeActionAffinityPubmed IDs
    DG-041
    AntagonistAntagonist10.118632791
    M&B 28767
    AgonistFull agonist9.910634944
    L-798,106
    AntagonistAntagonist9.6818632791
    PGE2
    AgonistFull agonist8.2 - 9.516604093 10634944
    [3H]PGE2
    AgonistFull agonist8.2 - 9.516604093 10634944
    sulprostone
    AgonistFull agonist9.4610634944
    L-826266 (sodium salt)
    AntagonistAntagonist9.111504634
    cloprostenol
    AgonistFull agonist8.410634944
    GR 63799
    AgonistFull agonist8.310634944
    misoprostol (free acid form)
    AgonistFull agonist8.110634944

    Selected Novoseek inferred chemical compound relationships for PTGER3 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butaprost 96.1 9 9530435 (1), 15888106 (1), 18932216 (1), 8149238 (1) (see all 8)
    sulprostone 95 23 9530435 (2), 9863659 (2), 7532011 (1), 10697805 (1) (see all 16)
    gr 63799x 92.7 4 9530435 (1), 8641211 (1)
    11-deoxy-pge1 92.6 3 12753465 (1), 16512814 (1), 9196397 (1)
    pge2 90 161 15331179 (5), 19212690 (4), 11997037 (4), 19416642 (3) (see all 83)
    prostaglandin 83.6 30 8396726 (1), 7532011 (1), 8908618 (1), 9065782 (1) (see all 20)
    ah23848 77.9 1 9888433 (1)
    17-phenyl-trinor-pge2 74.4 3 7970215 (1), 20381634 (1)
    pgd2 70.1 2 18005048 (1), 9730918 (1)
    iloprost 68.8 1 17690331 (1)

    1 PharmGKB related drug/compound annotation for PTGER3 gene    About this table
    Drug/compound PharmGKB Annotation
    Ace Inhibitors, PlainCA  



    Find genes that share compounds with PTGER3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PTGER3 gene (11 alternative transcripts): 
    NM_001126044.1  NM_198714.1  NM_198715.2  NM_198716.1  NM_198717.1  NM_198718.1  NM_198719.1  NM_000957.2  
    NM_198712.2  NM_198713.1  NM_198720.1  

    Unigene Cluster for PTGER3:

    Prostaglandin E receptor 3 (subtype EP3)
    Hs.445000  [show with all ESTs]
    Unigene Representative Sequence: NM_198715
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370931 ENST00000497146(uc001dfi.1) ENST00000479353(uc001dfj.1 uc009wbm.1)
    ENST00000361210(uc001dfh.1) ENST00000460330 ENST00000356595 ENST00000306666(uc001dfp.1)
    ENST00000370924(uc001dfq.3) ENST00000370932(uc001dfl.1) ENST00000354608(uc001dfm.1 uc001dfn.3 uc009wbn.2)
    ENST00000351052(uc001dfg.1 uc001dfk.1) ENST00000414819(uc009wbo.3 uc001dfo.3)

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    hsa-miR-4291 hsa-miR-106a hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-128 hsa-miR-183* hsa-miR-93 hsa-miR-34b
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    Additional mRNA sequence: 

    AB451481.1 AK290634.1 AK315825.1 AL050227.1 AY387856.1 AY429108.1 BC024229.1 BC118578.1 
    BC118659.1 D38297.1 D38298.1 D38299.1 D38300.1 D38301.1 D86097.1 D86098.1 
    EF534325.1 L26976.1 L27488.1 L27489.1 L27490.1 NR_028292.1 NR_028293.1 NR_028294.1 
    S68874.1 S69200.1 S69326.1 U13214.1 U13215.1 U13217.1 U13218.1 X83857.1 
    X83858.1 X83859.1 X83861.1 X83862.1 X83863.1 

    13 DOTS entries:

    DT.86854693  DT.86854689  DT.445098  DT.86854695  DT.411095  DT.86854688  DT.100748959  DT.100748960 
    DT.121367365  DT.92426581  DT.121367374  DT.306817  DT.92426580 

    Selected AceView cDNA sequences (see all 125):

    D38297 AI273491 H22163 NM_198719 AI017830 AI631905 AI984958 AA151583 
    NM_198715 AA058938 Z45064 Z40794 D38301 AI245380 AI093448 BF475870 
    AA025413 BQ716726 AA406418 BE501470 AL707597 AI335956 BX104537 D38298 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -     -           -     -           -                     
    SP2:                          -     -     -           -     -     -                           
    SP3:                          -           -                                                   
    SP4:                          -     -     -     -     -     -           -                     
    SP5:                          -                                                               


    ECgene alternative splicing isoforms for PTGER3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PTGER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGTACT
    PTGER3 Expression
    About this image


    PTGER3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells II Spleen
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     NULL (Uncategorized)
             Mast-like cells
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    PTGER3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PTGER3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445000

    UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115
    Tissue specificity: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and
    pulmonary vessels

        Pathway & Disease-focused RT2 Profiler PCR Array including PTGER3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for PTGER3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptger31 , 5 prostaglandin E receptor 3 (subtype EP3)1, 5 83.93(n)1
    86.53(a)1
      3 (81.32 cM)5
    192181  NM_011196.21  NP_035326.21 
     1575668925 
    chicken
    (Gallus gallus)
    Aves PTGER31 prostaglandin E receptor 3 (subtype EP3) 77.11(n)
    74.68(a)
      429116  NM_001040468.1  NP_001035558.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTGER36
    prostaglandin E receptor 3 (subtype EP3)
    59(a)
    1 ↔ 1
    GL343194.1(74539-98883)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ptger31 prostaglandin E receptor 3 (subtype EP3) 68.66(n)
    69.4(a)
      100495208  XM_002936086.2  XP_002936132.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000005441 prostaglandin E2 receptor EP3 subtype-like 61.69(n)
    61.05(a)
      100000544  XM_001340689.5  XP_001340725.3 


    ENSEMBL Gene Tree for PTGER3 (if available)
    TreeFam Gene Tree for PTGER3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PTGER3 gene
    PTGER12  PTGDR2  PTGER42  PTGFR2  PTGER22  TBXA2R2  PTGIR2  
    6 SIMAP similar genes for PTGER3 using alignment to 7 protein entries:     PE2R3_HUMAN (see all proteins):
    EP3 prostanoid receptor EP3-I    EP3-VI    EP3f    EP3-I    PTGFR    TBXA2R

    Find genes that share paralogs with PTGER3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PTGER3 (see all 3930)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679877331,2
    C--69469938(+) TTACA-/TGAG  
            
    TAAGA
    6 -- int10--------
    rs792260921,2
    C--69469939(+) TACATA/GAGTAA 6 -- int10--------
    rs61432711,2
    C--69477221(+) CAAGTGAGT/-  
            
    ATGTA
    6 -- int11Minor allele frequency- -:0.50NA 2
    rs799820011,2
    C--69487008(+) CTTGC-/AAAAAGA 6 -- int10--------
    rs340174051,2
    C--69488471(-) AATTT-/TGTAAC 6 -- int10--------
    rs2019709551,2
    --69497957(+) AAAAA-/TAAATA 6 -- int10--------
    rs358873221,2
    C--69499528(+) TTTTT-/T/TTT 
            
    GGCTC
    9 -- int1 cds10--------
    rs1435486641,2
    C--69504440(+) ATATT-/TATATAT 6 -- int10--------
    rs1491338401,2
    C--69505178(+) CAGAT-/ACACACA 6 -- int10--------
    rs589317881,2
    C--69511985(+) ATATA-/AA/   
       T
    /TAT
    AATAT
    9 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for PTGER3 (71318036 - 71513491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PTGER3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672048CNV Deletion23128226
    esv994407CNV Insertion20482838
    nsv871222CNV Loss21882294
    nsv871812CNV Loss21882294
    nsv870734CNV Loss21882294
    nsv871141CNV Loss21882294
    nsv871313CNV Loss21882294
    nsv516212CNV Loss19592680
    nsv871242CNV Loss21882294
    dgv238n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PTGER3
    DNA2.0 Custom Variant and Variant Library Synthesis for PTGER3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 176806    OMIM disorders: --

    2 diseases for PTGER3:    
    About MalaCards
    conjunctivochalasis    corneal disease

    2 diseases from the University of Copenhagen DISEASES database for PTGER3:
    Allergic conjunctivitis     Conjunctivochalasis

    Find genes that share disorders with PTGER3           About GenesLikeMe

    8 Novoseek inferred disease relationships for PTGER3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intestinal polyps 46.8 1 11533709 (1)
    mastocytoma 30.7 3 14577329 (1), 1372606 (1)
    colon cancer 17.4 12 15247185 (8)
    adenocarcinoma lung 12 5 15331179 (2), 11997037 (2)
    atherosclerotic plaque 7.73 3 16020747 (1), 16424787 (1)
    inflammation 3.27 2 20387535 (1)
    tumors 0 7 14751245 (1), 20145019 (1), 20100359 (1), 18715952 (1) (see all 5)
    carcinoma 0 4 19212690 (2)

    Genetic Association Database (GAD): PTGER3
    Human Genome Epidemiology (HuGE) Navigator: PTGER3 (19 documents)

    Export disorders for PTGER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PTGER3 gene, integrated from 10 sources (see all 272):
    (articles sorted by number of sources associating them with PTGER3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PubMed id 9073510)1, 2, 3, 9 Kotani M.... Nakao K. (Genomics 1997)
    2. Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population. (PubMed id 17877755)1, 4, 9 Park H.W....Cho S.H. (Clin. Exp. Allergy 2007)
    3. A new mRNA splice variant coding for the human EP3-I receptor isoform. (PubMed id 18023986)1, 2, 9 Kotelevets L....Norel X. (Prostaglandins Leukot. Essent. Fatty Acids 2007)
    4. Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue- specific distributions. (PubMed id 7476918)1, 2, 9 Kotani M.... Nakao K. (Mol. Pharmacol. 1995)
    5. Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. (PubMed id 7981210)1, 2, 9 An S.... Goetzl E.J. (Biochemistry 1994)
    6. Chromosomal localization of the human prostanoid receptor gene family. (PubMed id 7759114)1, 3, 9 Duncan A.M....Adam M. (Genomics 1995)
    7. Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. (PubMed id 8117308)1, 2, 9 Yang J.... An S. (Biochem. Biophys. Res. Commun. 1994)
    8. Cloning and expression of three isoforms of the human EP3 prostanoid receptor. (PubMed id 8307176)1, 2, 9 Adam M.... Abramovitz M. (FEBS Lett. 1994)
    9. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4, 9 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5733 HGNC: 9595 AceView: PTGER3 Ensembl:ENSG00000050628 euGenes: HUgn5733
    ECgene: PTGER3 Kegg: 5733 H-InvDB: PTGER3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PTGER3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PTGER3 gene:
    Search GeneIP for patents involving PTGER3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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