Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTGER3 Gene

Aliases for PTGER3 Gene

  • Prostaglandin E Receptor 3 2 3 5
  • Prostaglandin E Receptor 3 (Subtype EP3) 2 3
  • PGE2 Receptor EP3 Subtype 3 4
  • Prostanoid EP3 Receptor 3 4
  • PGE2-R 3 4
  • Prostaglandin E Receotor EP3 Subtype 3 Isoform 3
  • Prostaglandin E2 Receptor EP3 Subtype 3
  • Prostaglandin Receptor (PGE-2) 3
  • PGE Receptor, EP3 Subtype 3
  • PGE Receptor EP3 Subtype 4
  • EP3-III 3
  • EP3-II 3
  • EP3-IV 3
  • EP3-VI 3
  • EP3-I 3
  • EP3e 3
  • EP3 3

External Ids for PTGER3 Gene

Previous GeneCards Identifiers for PTGER3 Gene

  • GC01M071442
  • GC01M070241
  • GC01M070702
  • GC01M070688
  • GC01M070687
  • GC01M071030
  • GC01M071318
  • GC01M069428

Summaries for PTGER3 Gene

Entrez Gene Summary for PTGER3 Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for PTGER3 Gene

PTGER3 (Prostaglandin E Receptor 3) is a Protein Coding gene. Diseases associated with PTGER3 include Antenatal Bartter Syndrome and Hypersensitivity Syndrome, Carbamazepine-Induced. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot for PTGER3 Gene

  • Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Tocris Summary for PTGER3 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER3 Gene

Genomics for PTGER3 Gene

Regulatory Elements for PTGER3 Gene

Enhancers for PTGER3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F071086 0.2 ENCODE 29.3 -38.7 -38729 0.1 BHLHE40 MAFK PTGER3 LOC105378795 ZRANB2-AS2
GH01F070674 0.2 ENCODE 18 +372.1 372063 1.7 PKNOX1 ATF1 ARNT CBX5 GATA2 NCOA1 MBD2 SMARCA4 PBX2 NBN PTGER3 ZRANB2-AS1 MIR186 ZRANB2 CASP3P1 LINC01788
GH01F070979 0.2 Ensembl 8.8 +67.7 67714 1.0 ZNF316 TEAD4 MAFG EMSY MAFK SPI1 ENSG00000235782 PTGER3 GC01M070981
GH01F070949 0.4 Ensembl 8.3 +98.6 98609 0.8 CEBPB PTGER3 ENSG00000235782 GC01M070981
GH01F071089 0.4 ENCODE 5.9 -42.2 -42223 1.8 JUND MAFK PTGER3 LOC105378795 GC01M071183
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PTGER3 on UCSC Golden Path with GeneCards custom track

Promoters for PTGER3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001746366 14 800 TBP CREB3L1 NFRKB KLF13 EGR2 SP3 SMAD5 GTF2B POLR2H CBX8
ENSR00000538886 1613 1200 BCOR TBP RNF2 ETV1 NR4A1 ZNF407 UBTF ZSCAN29

Transcription factor binding sites by QIAGEN in the PTGER3 gene promoter:

Genomic Location for PTGER3 Gene

Chromosome:
1
Start:
70,852,353 bp from pter
End:
71,047,814 bp from pter
Size:
195,462 bases
Orientation:
Minus strand

Genomic View for PTGER3 Gene

Genes around PTGER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER3 Gene

Proteins for PTGER3 Gene

  • Protein details for PTGER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43115-PE2R3_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP3 subtype
    Protein Accession:
    P43115
    Secondary Accessions:
    • B0AZN4
    • B1AK19
    • B5BUP5
    • O00326
    • Q12943
    • Q12944
    • Q12945
    • Q16546
    • Q5CZ59
    • Q5CZ61
    • Q5CZ62
    • Q5CZ63
    • Q5CZ64

    Protein attributes for PTGER3 Gene

    Size:
    390 amino acids
    Molecular mass:
    43310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA58742.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};

    Alternative splice isoforms for PTGER3 Gene

neXtProt entry for PTGER3 Gene

Post-translational modifications for PTGER3 Gene

  • Glycosylation at Asn 18 and Asn 36
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for PTGER3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PTGER3

No data available for DME Specific Peptides for PTGER3 Gene

Domains & Families for PTGER3 Gene

Gene Families for PTGER3 Gene

Graphical View of Domain Structure for InterPro Entry

P43115

UniProtKB/Swiss-Prot:

PE2R3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER3: view

Function for PTGER3 Gene

Molecular function for PTGER3 Gene

GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Gene Ontology (GO) - Molecular Function for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004955 prostaglandin receptor activity IEA --
GO:0004957 prostaglandin E receptor activity NAS 9073510
genes like me logo Genes that share ontologies with PTGER3: view
genes like me logo Genes that share phenotypes with PTGER3: view

Animal Models for PTGER3 Gene

MGI Knock Outs for PTGER3:

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER3 Gene

Localization for PTGER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER3 Gene COMPARTMENTS Subcellular localization image for PTGER3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS 10336471
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8307176
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9073510
genes like me logo Genes that share ontologies with PTGER3: view

Pathways & Interactions for PTGER3 Gene

genes like me logo Genes that share pathways with PTGER3: view

SIGNOR curated interactions for PTGER3 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8307176
GO:0007189 NOT adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with PTGER3: view

Drugs & Compounds for PTGER3 Gene

(44) Drugs for PTGER3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 132
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 77
Misoprostol Approved Pharma Target, agonist 286
Alprostadil Approved, Investigational Pharma Prostaglandin. Vasodilator and antiplatelet agent in vivo 69
Dinoprostone Approved Pharma antagonist, Target, agonist 88

(17) Additional Compounds for PTGER3 Gene - From: Novoseek, IUPHAR, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-826266 (sodium salt)
Antagonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
sodium
  • Sodium
  • Sodium ion
7440-23-5

(5) Tocris Compounds for PTGER3 Gene

Compound Action Cas Number
Alprostadil Prostaglandin. Vasodilator and antiplatelet agent in vivo 745-65-3
Iloprost Prostacyclin (PGI2) analog 78919-13-8
L-798,106 Potent and highly selective EP3 antagonist 244101-02-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(3) ApexBio Compounds for PTGER3 Gene

Compound Action Cas Number
Alprostadil 745-65-3
Bimatoprost 155206-00-1
BMY 45778 Type I IL-1 receptor antagonist 152575-66-1
genes like me logo Genes that share compounds with PTGER3: view

Drug Products

Transcripts for PTGER3 Gene

Unigene Clusters for PTGER3 Gene

Prostaglandin E receptor 3 (subtype EP3):
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - - -
SP7:

Relevant External Links for PTGER3 Gene

GeneLoc Exon Structure for
PTGER3
ECgene alternative splicing isoforms for
PTGER3

Expression for PTGER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER3 Gene

This gene is overexpressed in Uterus (x8.2), Adipose - Visceral (Omentum) (x5.2), Adipose - Subcutaneous (x5.1), and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for PTGER3 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGER3 Gene



Protein tissue co-expression partners for PTGER3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTGER3 Gene:

PTGER3

SOURCE GeneReport for Unigene cluster for PTGER3 Gene:

Hs.445000

mRNA Expression by UniProt/SwissProt for PTGER3 Gene:

P43115-PE2R3_HUMAN
Tissue specificity: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
genes like me logo Genes that share expression patterns with PTGER3: view

Primer Products

Orthologs for PTGER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGER3 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia PTGER3 34
  • 88.95 (n)
cow
(Bos Taurus)
Mammalia PTGER3 34 35
  • 86.43 (n)
mouse
(Mus musculus)
Mammalia Ptger3 34 16 35
  • 83.93 (n)
rat
(Rattus norvegicus)
Mammalia Ptger3 34
  • 83.38 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTGER3 34
  • 77.11 (n)
EP3 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER3 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger3 34
  • 68.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100000544 34
  • 61.69 (n)
ptger3 35
  • 53 (a)
OneToOne
Species where no ortholog for PTGER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER3 Gene

ENSEMBL:
Gene Tree for PTGER3 (if available)
TreeFam:
Gene Tree for PTGER3 (if available)

Paralogs for PTGER3 Gene

Paralogs for PTGER3 Gene

genes like me logo Genes that share paralogs with PTGER3: view

Variants for PTGER3 Gene

Sequence variations from dbSNP and Humsavar for PTGER3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1005747 -- 71,045,832(+) ATGGC(A/G)AAGGG intron-variant, upstream-variant-2KB
rs1005748 -- 71,045,835(+) GCAAA(A/G)GGCTG intron-variant, upstream-variant-2KB
rs1005749 -- 71,045,915(+) GCAGT(C/G)TTTCA intron-variant, upstream-variant-2KB
rs1008484 -- 71,019,972(-) CCATA(A/G)CCTAA intron-variant
rs10218772 -- 70,922,135(+) gttca(A/T)tttaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGER3 Gene

Variant ID Type Subtype PubMed ID
dgv177n100 CNV loss 25217958
dgv22e214 CNV loss 21293372
esv2138101 CNV deletion 18987734
esv2672048 CNV deletion 23128226
esv2762149 CNV loss 21179565
esv3342245 CNV insertion 20981092
esv3577913 CNV loss 25503493
esv3577914 CNV loss 25503493
esv3586370 CNV loss 21293372
esv3586371 CNV loss 21293372
esv3893657 CNV loss 25118596
esv994407 CNV insertion 20482838
nsv461851 CNV gain 19166990
nsv516212 CNV loss 19592680
nsv546471 CNV loss 21841781
nsv546472 CNV gain 21841781
nsv546473 CNV gain 21841781
nsv830148 CNV gain 17160897

Variation tolerance for PTGER3 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGER3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER3 Gene

Disorders for PTGER3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTGER3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
antenatal bartter syndrome
  • hyperprostaglandin e syndrome
hypersensitivity syndrome, carbamazepine-induced
  • toxic epidermal necrolysis
ocular hyperemia
  • hyperemia eye
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTGER3

Genetic Association Database (GAD)
PTGER3
Human Genome Epidemiology (HuGE) Navigator
PTGER3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGER3
genes like me logo Genes that share disorders with PTGER3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER3 Gene

Publications for PTGER3 Gene

  1. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PMID: 9073510) Kotani M. … Nakao K. (Genomics 1997) 2 3 4 22 64
  2. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman K.K. … Jacobsson B. (PLoS ONE 2010) 3 22 46 64
  3. Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population. (PMID: 17877755) Park H.W. … Cho S.H. (Clin. Exp. Allergy 2007) 3 22 46 64
  4. A new mRNA splice variant coding for the human EP3-I receptor isoform. (PMID: 18023986) Kotelevets L. … Norel X. (Prostaglandins Leukot. Essent. Fatty Acids 2007) 3 4 22 64
  5. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 3 22 64

Products for PTGER3 Gene

Sources for PTGER3 Gene

Content
Loading form....