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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTGER3 Gene

protein-coding GIFtS: 67
GCID: GC01M071318

prostaglandin E receptor 3 (subtype EP3)

Explore 40 diseases affiliated with
PTGER3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Prostaglandin E Receptor 3 (Subtype EP3)¹ ²		EP3-IV²
EP3¹ ² ⁵		EP3e²
Prostanoid EP3 Receptor² ³		PGE Receptor, EP3 Subtype²
PGE2-R² ³		Prostaglandin E Receotor EP3 Subtype 3 Isoform²
PGE2 Receptor EP3 Subtype² ³		Prostaglandin E2 Receptor EP3 Subtype²
EP3-I²		Prostaglandin Receptor (PGE-2)²
EP3-II²		PGE Receptor EP3 Subtype³
EP3-III²

External Ids:	HGNC: 9595¹	Entrez Gene: 5733²	Ensembl: ENSG00000050628⁷	OMIM: 176806⁵	UniProtKB: P43115³

ORGUL members:
	NONCODE:n408171 n408169

Export aliases for PTGER3 gene to outside databases

Previous GC identifers: GC01M071442 GC01M070241 GC01M070702 GC01M070688 GC01M070687 GC01M071030 GC01M069428

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGER3:

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four

receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve

digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart

suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in

response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found

for this gene. (provided by RefSeq, Aug 2009)

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115

Function: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid

secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water

reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to

both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The

various isoforms have identical ligand binding properties but can interact with different second messenger systems (By

similarity)

summary for PTGER3:

Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,

prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which

the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled

receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of

prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle

contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory

receptor that prevents smooth muscle relaxation.

Gene Wiki entry for PTGER3 (Prostaglandin E receptor 3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTGER3 gene promoter:
TBP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTGER3 promoter sequence

Search SABiosciences Chromatin IP Primers for PTGER3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGER3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.2 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.2

PTGER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGER3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M071318: view genomic region (about GC identifiers)

Start:	71,318,036 bp from pter	End:	71,513,491 bp from pter
Size:	195,456 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

n408169
n408171

lncRNA
Full Legend

71318035 71415763 71513491 chr1

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115 (See protein sequence)

Recommended Name: Prostaglandin E2 receptor EP3 subtype

Size: 390 amino acids; 43310 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B0AZN4 B5BUP5 O00326 Q12943 Q12944 Q12945 Q16546

Alternative splicing: 7 isoforms: P43115-1 P43115-2 P43115-3 P43115-4 P43115-5 P43115-6 P43115-7 (Known as EP3F in PubMed:8075855)

Explore the universe of human proteins at neXtProt for PTGER3: NX_P43115

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P43115

PTGER3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001119516.1 NP_942007.1 NP_942008.1 NP_942009.1 NP_942010.1 NP_942011.1 NP_942012.1

ENSEMBL proteins:

ENSP00000359969 ENSP00000423561 ENSP00000421583 ENSP00000424340 ENSP00000418073

ENSP00000349003 ENSP00000302313 ENSP00000359962 ENSP00000359970 ENSP00000346624

ENSP00000280208 ENSP00000401423

Reactome Protein details: P43115
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PTGER3 Protein
	Browse R&D Systems for human recombinant proteins
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	Novus Biologicals PTGER3 Proteins Novus Biologicals PTGER3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTGER3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005635	nuclear envelope	TAS	10336471
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8307176
GO:0016021	integral to membrane	NAS	9073510

PTGER3 for ontologies About GeneDecksing

PTGER3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGER3
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	GenScript Custom Superior Antibodies Services for PTGER3
	Novus Biologicals PTGER3 Antibodies
	Search for Antibodies for PTGER3 at Abcam
	Uscn Antibodies for PTGER3
	ThermoFisher Antibodies for PTGER3

Assay Products for PTGER3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PTGER3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTGER3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTGER3 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017452 GPCR_Rhodpsn_7TM

IPR008365 Prostanoid_rcpt

IPR000265 Prostglndn_EP3_rcpt

IPR001481 EP3_rcpt_2

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P43115

ProtoNet protein and cluster: P43115

3 Blocks protein families:

IPB000265 Prostanoid EP3 receptor signature

IPB001244 Prostaglandin receptor signature

IPB001481 Prostanoid EP3 receptor type 2 signature

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115

Function: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid

secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water

reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to

both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The

various isoforms have identical ligand binding properties but can interact with different second messenger systems (By

prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily

miRNA Products:		OriGene 3'-UTR Clone (see all 7): PTGER3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGER3
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGER3 (see all 43):
		hsa-miR-4291 hsa-miR-106a hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-128 hsa-miR-183* hsa-miR-93 hsa-miR-34b

		SwitchGear 3'UTR luciferase reporter plasmid: PTGER3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGER3 (see all 7) OriGene shRNA RFP: PTGER3 OriGene siRNA: PTGER3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGER3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PTGER3

Clone Products:		EMD Millipore Clones for the Expression of PTGER3
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTGER3 (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTGER3 (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): PTGER3 (NM_001126044)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGER3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGER3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTGER3
		Search LifeMap BioReagents cell lines for PTGER3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGER3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	TAS	10336471
GO:0004957	prostaglandin E receptor activity	NAS	9073510
GO:0005515	protein binding	--	--

PTGER3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PTGER3:

Increased circadian period len

Animal Models:
Mouse knock-out Ptger3^tm1Cof for PTGER3
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ptger3):

behavior/neurological	cardiovascular system	homeostasis/metabolism	immune system	integument
mortality/aging	muscle	renal/urinary system

PTGER3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Prostanoid ligand receptors

	Prostanoid ligand receptors	1.00			Small Ligand GPCRs	0.42
	Eicosanoid ligand-binding receptors	0.60

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

PKA activation in glucagon signalling

Neurophysiological process PGE2-induced pain processing

0.44

Neurophysiological process_PGE2-induced pain processing

0.44

Celecoxib Pathway, Pharmacodynamics

Celecoxib Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PTGER3

Neurophysiological process PGE2-induced pain processing

1 GeneGo (Thomson Reuters) Pathway for PTGER3

Neurophysiological process PGE2-induced pain processing

3 BioSystems Pathways for PTGER3

	GPCRs, Class A Rhodopsin-like
	Prostaglandin Synthesis and Regulation
	Small Ligand GPCRs

5/8 Reactome Pathways for PTGER3 (see all 8)

	GPCR downstream signaling
	Eicosanoid ligand-binding receptors
	Prostanoid ligand receptors
	Signal Transduction
	Signaling by GPCR

1 PharmGKB Pathway for PTGER3

Celecoxib Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for PTGER3):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction

PTGER3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTGER3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/149 Interacting proteins for PTGER3 (P43115³ ENSP00000349003⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 149)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTGER1	P34995³, ENSP00000292513⁴	I2D: score=1 STRING: ENSP00000292513
GNAI2	P04899³, ENSP00000312999⁴	I2D: score=1 STRING: ENSP00000312999
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY9	ENSP00000294016⁴	STRING: ENSP00000294016
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001660	fever generation	--	--
GO:0006351	transcription, DNA-dependent	TAS	10336471
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8307176
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	--	--
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	--	--

PTGER3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTGER3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PTGER3 available from Tocris Bioscience About this table

Compound	Action	CAS #
16,16-Dimethyl Prostaglandin E2	Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development	[39746-25-3]
Alprostadil	Prostaglandin. Vasodilator and antiplatelet agent in vivo	[745-65-3]
L-798,106	Potent and highly selective EP3 antagonist	[244101-02-8]
Prostaglandin E2	Major endogenous prostanoid	[363-24-6]

3 HMDB Compounds for PTGER3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Prostaglandin E2	(-)-Prostaglandin E2 (see all 22)	363-24-6	--
Sodium	Sodium (see all 2)	7440-23-5	--

3 DrugBank Compounds for PTGER3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Misoprostol	--	59122-46-2	target	agonist	16039053 18472336 11602631 12097143 9313928
Dinoprostone	Dinoprostone Prostaglandin E2 (see all 3)	363-24-6	target	agonist	18715952 19788928 20599704 17329241
Bimatoprost	--	155206-00-1	target	agonist	19232013 16877408 14733708

10/27 Novoseek chemical compound relationships for PTGER3 gene (see all 27) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
butaprost	96.1	9	9530435 (1), 15888106 (1), 18932216 (1), 8149238 (1) (see all 8)
sulprostone	95	23	9530435 (2), 9863659 (2), 7532011 (1), 10697805 (1) (see all 16)
gr 63799x	92.7	4	9530435 (1), 8641211 (1)
11-deoxy-pge1	92.6	3	12753465 (1), 16512814 (1), 9196397 (1)
pge2	90	161	15331179 (5), 19212690 (4), 11997037 (4), 19416642 (3) (see all 83)
prostaglandin	83.6	30	8396726 (1), 7532011 (1), 8908618 (1), 9065782 (1) (see all 20)
ah23848	77.9	1	9888433 (1)
17-phenyl-trinor-pge2	74.4	3	7970215 (1), 20381634 (1)
pgd2	70.1	2	18005048 (1), 9730918 (1)
iloprost	68.8	1	17690331 (1)

1 PharmGKB related drug/compound annotation for PTGER3 gene

Drug/compound	PharmGKB Annotation
"Ace Inhibitors, Plain"	CA

About this table

Search CenterWatch for drugs/clinical trials and news about PTGER3 / PE2R3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTGER3 gene (11 alternative transcripts):

NM_001126044.1 NM_198714.1 NM_198715.2 NM_198716.1 NM_198717.1 NM_198718.1 NM_198719.1 NM_000957.2

NM_198712.2 NM_198713.1 NM_198720.1

Unigene Cluster for PTGER3:

Prostaglandin E receptor 3 (subtype EP3)

Hs.445000 [show with all ESTs]

Unigene Representative Sequence: NM_198715

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370931 ENST00000497146(uc001dfi.1) ENST00000479353(uc001dfj.1 uc009wbm.1)

ENST00000361210(uc001dfh.1) ENST00000460330 ENST00000356595 ENST00000306666(uc001dfp.1)

ENST00000370924(uc001dfq.3) ENST00000370932(uc001dfl.1) ENST00000354608(uc001dfm.1 uc001dfn.3 uc009wbn.2)

ENST00000351052(uc001dfg.1 uc001dfk.1) ENST00000414819(uc009wbo.3 uc001dfo.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGER3
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGER3 (see all 43):
		hsa-miR-4291 hsa-miR-106a hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-128 hsa-miR-183* hsa-miR-93 hsa-miR-34b

		SwitchGear 3'UTR luciferase reporter plasmid: PTGER3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGER3 (see all 7) OriGene shRNA RFP: PTGER3 OriGene siRNA: PTGER3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTGER3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTGER3 (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTGER3 (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): PTGER3 (NM_001126044)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGER3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGER3

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PTGER3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTGER3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGER3

Additional cDNA sequence:

AB451481.1 AK290634.1 AK315825.1 AL050227.1 AY387856.1 AY429108.1 BC024229.1 BC118578.1

BC118659.1 D38297.1 D38298.1 D38299.1 D38300.1 D38301.1 D86097.1 D86098.1

EF534325.1 L26976.1 L27488.1 L27489.1 L27490.1 NR_028292.1 NR_028293.1 NR_028294.1

S68874.1 S69200.1 S69326.1 U13214.1 U13215.1 U13217.1 U13218.1 X83857.1

X83858.1 X83859.1 X83861.1 X83862.1 X83863.1

13 DOTS entries:

DT.86854693 DT.86854689 DT.445098 DT.86854695 DT.411095 DT.86854688 DT.100748959 DT.100748960

DT.121367365 DT.92426581 DT.121367374 DT.306817 DT.92426580

24/125 AceView cDNA sequences (see all 125):

D38300 NM_198719 D86098 AA406418 AI301762 BX104537 NM_198720 AY429108

BF475870 AI263014 D38301 BQ716726 L27489 BF224423 NM_198712 H22163

BG742211 Z45064 AI273491 AL700353 AI335956 D38299 AI631905 Z40794

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b
SP1:									-		-		-				-		-				-
SP2:									-		-		-				-		-		-
SP3:									-				-
SP4:									-		-		-		-		-		-				-
SP5:									-

ECgene alternative splicing isoforms for PTGER3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTGER3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTGTACT

About this image

PTGER3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Adipose

Body Subcutaneous White Adipose

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mast-like cells (Generation of hemato...)

See PTGER3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTGER3

SOURCE GeneReport for Unigene cluster: Hs.445000

UniProtKB/Swiss-Prot: PE2R3_HUMAN, P43115

Tissue specificity: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary

vessels

SABiosciences Expression via Pathway-Focused PCR Array including PTGER3:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTGER3 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTGER3¹	prostaglandin E receptor 3 (subtype EP3)	77.11(n) 74.68(a)		429116 NM_001040468.1 NP_001035558.1
lizard (Anolis carolinensis)	Reptilia	PTGER3⁶	--	63(a)	1 ↔ 1	GL343194.1(79424-98215)
zebrafish (Danio rerio)	Actinopterygii	LOC100000544¹	prostaglandin E2 receptor EP3 subtype-like	62.31(n) 61.39(a)		100000544 XM_001340689.4 XP_001340725.2
fruit fly (Drosophila melanogaster)	Insecta	CG7497⁶	--	18(a)	possible ortholog	3L(17626549-17630975)

ENSEMBL Gene Tree for PTGER3 (if available)
TreeFam Gene Tree for PTGER3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTGER3 gene

PTGDR² PTGER1² PTGER4² PTGFR² PTGER2² TBXA2R² PTGIR²

10 SIMAP similar genes for PTGER3 using alignment to 7 protein entries: PE2R3_HUMAN (see all proteins):

EP3 prostanoid receptor EP3-I EP3-III EP3-IV EP3-VI EP3-V EP3f

EP3e EP3-I PTGFR TBXA2R

PTGER3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12096600^1,2	C,F,H,	--	69428797(+)	`AAAATT/GAACGA`	6	--	ut3¹ nc-transcript-variant		10	NS EA NA WA	1210
rs5672^1,2	C,F	--	69428953(-)	`TGTACT/CTTTAC`	6	--	ut3¹ nc-transcript-variant		1	MN	80
rs61777096^1,2		--	69430492(+)	`CCTACG/AAGATG`	6	--	int¹		2	NA	122
rs72932106^1,2	C,	--	69431552(+)	`CACCTG/TTATAA`	6	--	int¹		1	WA	2
rs79377744^1,2		--	69431619(+)	`AGGAAG/AGGGAA`	6	--	int¹		2	CSA WA	120
rs78340497^1,2	F,	--	69432678(+)	`AAGTTG/TCAGTG`	6	--	int¹		1	EA	120
rs12067724^1,2	C,F,H,	--	69433602(+)	`CACATA/GCAAAA`	6	--	int¹		5	NS EA WA	532
rs79154032^1,2	C,	--	69434520(+)	`NNNNGG/TTACAA`	6	--	int¹		2	NA	122
rs79749642^1,2		--	69435215(+)	`TGGAAG/ATTTAA`	6	--	int¹		2	CSA WA	120
rs12126078^1,2	C,F,	--	69435699(+)	`TCATTA/GGTTTT`	6	--	int¹		4	NA	126

HapMap Linkage Disequilibrium report for PTGER3 (71318036 - 71513491 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PTGER3
1 CNV: 84295

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTGER3 for disorders           About GeneDecksing

OMIM gene information: 176806    OMIM disorders: --

20/40 diseases for PTGER3 (see all 40):    About MalaCards

stevens-johnson syndrome abdominal aortic aneurysm mooren's ulcer aortic aneurysm

oral squamous cell carcinoma conjunctivochalasis squamous cell carcinoma pulmonary edema

epithelial ovarian cancer essential hypertension endometritis inflammatory breast cancer

adenomyosis rheumatoid arthritis colon cancer ovarian cancer

hepatitis b breast cancer duodenitis lung adenocarcinoma

1 disease from the University of Copenhagen DISEASES database for PTGER3:

Allergic conjunctivitis

8 Novoseek disease relationships for PTGER3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
intestinal polyps	46.8	1	11533709 (1)
mastocytoma	30.7	3	14577329 (1), 1372606 (1)
colon cancer	17.4	12	15247185 (8)
adenocarcinoma lung	12	5	15331179 (2), 11997037 (2)
atherosclerotic plaque	7.73	3	16020747 (1), 16424787 (1)
inflammation	3.27	2	20387535 (1)
tumors	0	7	14751245 (1), 20145019 (1), 20100359 (1), 18715952 (1) (see all 5)
carcinoma	0	4	19212690 (2)

Human Genome Epidemiology (HuGE) Navigator: PTGER3 (19 documents)

Export disorders for PTGER3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PTGER3 gene, integrated from 9 sources (see all 263):
(articles sorted by number of sources associating them with PTGER3)

Utopia: connect your pdf to the dynamic
world of online information

Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PubMed id 9073510)^{1, 2, 3, 9} Kotani M....Nakao K. (1997)
A new mRNA splice variant coding for the human EP3-I receptor isoform. (PubMed id 18023986)^{1, 2, 9} Kotelevets L....Norel X. (2007)
Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue- specific distributions. (PubMed id 7476918)^{1, 2, 9} Kotani M.... Nakao K. (1995)
Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. (PubMed id 7981210)^{1, 2, 9} An S.... Goetzl E.J. (1994)
Chromosomal localization of the human prostanoid receptor gene family. (PubMed id 7759114)^{1, 3, 9} Duncan A.M....Adam M. (1995)
Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. (PubMed id 8117308)^{1, 2, 9} Yang J.... An S. (1994)
Cloning and expression of three isoforms of the human EP3 prostanoid receptor. (PubMed id 8307176)^{1, 2, 9} Adam M.... Abramovitz M. (1994)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Splice variants of the human EP3 receptor for prostaglandin E2. (PubMed id 7883006)^{1, 2} Schmid A.... Dinter H. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5733	HGNC: 9595	AceView: PTGER3	Ensembl:ENSG00000050628	euGenes: HUgn5733
ECgene: PTGER3	Kegg: 5733	H-InvDB: PTGER3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PTGER3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PTGER3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PTGER3 gene:
Search GeneIP for patents involving PTGER3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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prostaglandin E receptor 3 (subtype EP3)

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PTGER3 Gene

prostaglandin E receptor 3 (subtype EP3)

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