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Aliases for PTGER3 Gene

Aliases for PTGER3 Gene

  • Prostaglandin E Receptor 3 (Subtype EP3) 2 3
  • PGE2 Receptor EP3 Subtype 3 4
  • Prostanoid EP3 Receptor 3 4
  • PGE2-R 3 4
  • EP3 3 6
  • Prostaglandin E Receotor EP3 Subtype 3 Isoform 3
  • Prostaglandin E2 Receptor EP3 Subtype 3
  • Prostaglandin Receptor (PGE-2) 3
  • PGE Receptor, EP3 Subtype 3
  • PGE Receptor EP3 Subtype 4
  • EP3-III 3
  • EP3-II 3
  • EP3-IV 3
  • EP3-I 3
  • EP3e 3

External Ids for PTGER3 Gene

Previous GeneCards Identifiers for PTGER3 Gene

  • GC01M071442
  • GC01M070241
  • GC01M070702
  • GC01M070688
  • GC01M070687
  • GC01M071030
  • GC01M071318
  • GC01M069428

Summaries for PTGER3 Gene

Entrez Gene Summary for PTGER3 Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for PTGER3 Gene

PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3)) is a Protein Coding gene. Diseases associated with PTGER3 include antenatal bartter syndrome and conjunctivochalasis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and prostaglandin E receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGER3 Gene

  • Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Tocris Summary for PTGER3 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory receptor that prevents smooth muscle relaxation.

Gene Wiki entry for PTGER3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER3 Gene

Genomics for PTGER3 Gene

Regulatory Elements for PTGER3 Gene

Transcription factor binding sites by QIAGEN in the PTGER3 gene promoter:

Genomic Location for PTGER3 Gene

Start:
70,852,353 bp from pter
End:
71,047,808 bp from pter
Size:
195,456 bases
Orientation:
Minus strand

Genomic View for PTGER3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER3 Gene

Proteins for PTGER3 Gene

  • Protein details for PTGER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43115-PE2R3_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP3 subtype
    Protein Accession:
    P43115
    Secondary Accessions:
    • B0AZN4
    • B1AK19
    • B5BUP5
    • O00326
    • Q12943
    • Q12944
    • Q12945
    • Q16546
    • Q5CZ59
    • Q5CZ61
    • Q5CZ62
    • Q5CZ63
    • Q5CZ64

    Protein attributes for PTGER3 Gene

    Size:
    390 amino acids
    Molecular mass:
    43310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA58742.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};

    Alternative splice isoforms for PTGER3 Gene

neXtProt entry for PTGER3 Gene

Proteomics data for PTGER3 Gene at MOPED

Post-translational modifications for PTGER3 Gene

  • Glycosylation at Asn18 and Asn36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PTGER3 Gene

Domains for PTGER3 Gene

Gene Families for PTGER3 Gene

HGNC:
  • PTGR :GPCR / Class A : Prostanoid receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P43115

UniProtKB/Swiss-Prot:

PE2R3_HUMAN :
  • P43115
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER3: view

Function for PTGER3 Gene

Molecular function for PTGER3 Gene

GENATLAS Biochemistry: prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Gene Ontology (GO) - Molecular Function for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS 10336471
GO:0004930 G-protein coupled receptor activity --
GO:0004957 prostaglandin E receptor activity NAS 9073510
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PTGER3: view
genes like me logo Genes that share phenotypes with PTGER3: view

Animal Models for PTGER3 Gene

MGI Knock Outs for PTGER3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PTGER3 Gene

Localization for PTGER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER3 Gene COMPARTMENTS Subcellular localization image for PTGER3 gene
Compartment Confidence
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS 10336471
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8307176
GO:0016021 integral component of membrane NAS 9073510
genes like me logo Genes that share ontologies with PTGER3: view

Pathways for PTGER3 Gene

genes like me logo Genes that share pathways with PTGER3: view

Pathways by source for PTGER3 Gene

Gene Ontology (GO) - Biological Process for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001660 fever generation IEA --
GO:0006351 transcription, DNA-templated TAS 10336471
GO:0007186 G-protein coupled receptor signaling pathway TAS 8307176
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PTGER3: view

Compounds for PTGER3 Gene

(5) Tocris Compounds for PTGER3 Gene

Compound Action Cas Number
L-161,982 Selective EP4 receptor antagonist [147776-06-5]
L-798,106 Potent and highly selective EP3 antagonist [244101-02-8]
Prostaglandin E2 Major endogenous prostanoid [363-24-6]
TCS 2510 Selective EP4 agonist [346673-06-1]
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]

(3) HMDB Compounds for PTGER3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Prostaglandin E2
  • (-)-Prostaglandin E2
363-24-6
Sodium
  • Sodium
7440-23-5

(3) Drugbank Compounds for PTGER3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Bimatoprost
155206-00-1 target agonist
Dinoprostone
  • Dinoprostone Prostaglandin E2
363-24-6 target agonist
Misoprostol
59122-46-2 target agonist

(23) IUPHAR Ligand for PTGER3 Gene

Ligand Type Action Affinity Pubmed IDs
DG-041 Antagonist Antagonist 10.1
L-798,106 Antagonist Antagonist 9.68
L-826266 (sodium salt) Antagonist Antagonist 9.1
GR 63799 Agonist Full agonist 8.3
SC-51322 Antagonist Antagonist 7.9
enprostil Agonist Full agonist 7.8
misoprostol (free acid form) Agonist Full agonist 7.5
U46619 Agonist Full agonist 7.5
treprostinil Agonist Full agonist 7.49
sulprostone Agonist Full agonist 7
ONO-AE-248 Agonist Full agonist 6.7
M&B 28767 Agonist Full agonist 6.5
AH6809 Antagonist Antagonist 6
cicaprost Agonist Full agonist 5.9
cloprostenol Agonist Full agonist 5.2
iloprost Agonist Full agonist 5.2
PGF2alpha Agonist Full agonist 5.1
misoprostol (methyl ester) Agonist Full agonist 5
carbacyclin Agonist Full agonist 4.7
butaprost (free acid form) Agonist Full agonist 4.7
PGE2 Agonist Full agonist 4.5
fluprostenol Agonist Full agonist 4.3
[3H]PGE2 None None

(27) Novoseek inferred chemical compound relationships for PTGER3 Gene

Compound -log(P) Hits PubMed IDs
butaprost 96.1 8
sulprostone 95 18
gr 63799x 92.7 2
11-deoxy-pge1 92.6 3
pge2 90 106

(1) PharmGKB related drug/compound annotations for PTGER3 Gene

Drug/compound Annotation
"Ace Inhibitors, Plain" CA
genes like me logo Genes that share compounds with PTGER3: view

Transcripts for PTGER3 Gene

Unigene Clusters for PTGER3 Gene

Prostaglandin E receptor 3 (subtype EP3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - - -
SP7:

Relevant External Links for PTGER3 Gene

GeneLoc Exon Structure for
PTGER3
ECgene alternative splicing isoforms for
PTGER3

Expression for PTGER3 Gene

mRNA expression in normal human tissues for PTGER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER3 Gene

This gene is overexpressed in Uterus (8.2), Adipose - Visceral (Omentum) (5.2), Adipose - Subcutaneous (5.1), and Kidney - Cortex (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTGER3 Gene

SOURCE GeneReport for Unigene cluster for PTGER3 Gene Hs.445000

mRNA Expression by UniProt/SwissProt for PTGER3 Gene

P43115-PE2R3_HUMAN
Tissue specificity: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
genes like me logo Genes that share expressions with PTGER3: view

Orthologs for PTGER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGER3 35
  • 99.68 (n)
  • 99.52 (a)
PTGER3 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGER3 35
  • 86.43 (n)
  • 85.32 (a)
PTGER3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGER3 35
  • 88.95 (n)
  • 88.59 (a)
mouse
(Mus musculus)
Mammalia Ptger3 35
  • 83.93 (n)
  • 86.53 (a)
Ptger3 16
Ptger3 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ptger3 35
  • 83.38 (n)
  • 85.97 (a)
chicken
(Gallus gallus)
Aves EP3 36
  • 66 (a)
OneToOne
PTGER3 35
  • 77.11 (n)
  • 74.68 (a)
lizard
(Anolis carolinensis)
Reptilia PTGER3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger3 35
  • 68.66 (n)
  • 69.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100000544 35
  • 61.69 (n)
  • 61.05 (a)
ptger3 36
  • 53 (a)
OneToOne
Species with no ortholog for PTGER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER3 Gene

ENSEMBL:
Gene Tree for PTGER3 (if available)
TreeFam:
Gene Tree for PTGER3 (if available)

Paralogs for PTGER3 Gene

Paralogs for PTGER3 Gene

genes like me logo Genes that share paralogs with PTGER3: view

Variants for PTGER3 Gene

Sequence variations from dbSNP and Humsavar for PTGER3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5673 -- 71,012,158(-) AACCT(A/T)ACTGT intron-variant, utr-variant-3-prime
rs5674 -- 71,011,927(-) TCTTG(G/T)TCTAT intron-variant, utr-variant-3-prime
rs5675 -- 71,011,856(-) CATCA(C/T)TGAAG intron-variant, utr-variant-3-prime
rs5676 -- 71,011,715(-) ATTTA(A/T)AATAT intron-variant, utr-variant-3-prime
rs5677 -- 71,011,697(-) TACCA(G/T)TATTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTGER3 Gene

Variant ID Type Subtype PubMed ID
nsv830148 CNV Gain 17160897
nsv871604 CNV Gain 21882294
esv994407 CNV Insertion 20482838
nsv871313 CNV Loss 21882294
nsv516212 CNV Loss 19592680
nsv871222 CNV Loss 21882294
nsv871141 CNV Loss 21882294
nsv461851 CNV Gain 19166990
dgv238n71 CNV Loss 21882294
nsv870734 CNV Loss 21882294
nsv871812 CNV Loss 21882294
nsv871242 CNV Loss 21882294
nsv871147 CNV Gain 21882294
esv2672048 CNV Deletion 23128226

Relevant External Links for PTGER3 Gene

HapMap Linkage Disequilibrium report
PTGER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER3 Gene

Disorders for PTGER3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PTGER3 Gene including...

Search for PTGER3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for PTGER3 Gene

(8) Novoseek inferred disease relationships for PTGER3 Gene

Disease -log(P) Hits PubMed IDs
intestinal polyps 46.8 1
mastocytoma 30.7 2
colon cancer 17.4 8
adenocarcinoma lung 12 4
atherosclerotic plaque 7.73 2

Relevant External Links for PTGER3

Genetic Association Database (GAD)
PTGER3
Human Genome Epidemiology (HuGE) Navigator
PTGER3
genes like me logo Genes that share disorders with PTGER3: view

No data available for UniProtKB/Swiss-Prot for PTGER3 Gene

Publications for PTGER3 Gene

  1. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PMID: 9073510) Kotani M. … Nakao K. (Genomics 1997) 2 3 4 23
  2. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 3 23
  3. Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. (PMID: 7981210) An S. … Goetzl E.J. (Biochemistry 1994) 3 4 23
  4. Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. (PMID: 8117308) Yang J. … An S. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  5. Cloning and expression of three isoforms of the human EP3 prostanoid receptor. (PMID: 8307176) Adam M. … Abramovitz M. (FEBS Lett. 1994) 3 4 23

Products for PTGER3 Gene

Sources for PTGER3 Gene

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