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Aliases for PTGER3 Gene

Aliases for PTGER3 Gene

  • Prostaglandin E Receptor 3 2 3 5
  • Prostaglandin E Receptor 3 (Subtype EP3) 2 3
  • PGE2 Receptor EP3 Subtype 3 4
  • Prostanoid EP3 Receptor 3 4
  • PGE2-R 3 4
  • Prostaglandin E Receotor EP3 Subtype 3 Isoform 3
  • Prostaglandin Receptor (PGE-2) 3
  • PGE Receptor, EP3 Subtype 3
  • PGE Receptor EP3 Subtype 4
  • EP3-III 3
  • EP3-II 3
  • EP3-IV 3
  • EP3-VI 3
  • EP3-I 3
  • EP3e 3
  • EP3 3

External Ids for PTGER3 Gene

Previous GeneCards Identifiers for PTGER3 Gene

  • GC01M071442
  • GC01M070241
  • GC01M070702
  • GC01M070688
  • GC01M070687
  • GC01M071030
  • GC01M071318
  • GC01M069428

Summaries for PTGER3 Gene

Entrez Gene Summary for PTGER3 Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for PTGER3 Gene

PTGER3 (Prostaglandin E Receptor 3) is a Protein Coding gene. Diseases associated with PTGER3 include antenatal bartter syndrome and hypersensitivity syndrome, carbamazepine-induced. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGER3 Gene

  • Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Tocris Summary for PTGER3 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER3 Gene

Genomics for PTGER3 Gene

Regulatory Elements for PTGER3 Gene

Promoters for PTGER3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTGER3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PTGER3 gene promoter:

Genomic Location for PTGER3 Gene

Chromosome:
1
Start:
70,852,353 bp from pter
End:
71,047,814 bp from pter
Size:
195,462 bases
Orientation:
Minus strand

Genomic View for PTGER3 Gene

Genes around PTGER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER3 Gene

Proteins for PTGER3 Gene

  • Protein details for PTGER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43115-PE2R3_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP3 subtype
    Protein Accession:
    P43115
    Secondary Accessions:
    • B0AZN4
    • B1AK19
    • B5BUP5
    • O00326
    • Q12943
    • Q12944
    • Q12945
    • Q16546
    • Q5CZ59
    • Q5CZ61
    • Q5CZ62
    • Q5CZ63
    • Q5CZ64

    Protein attributes for PTGER3 Gene

    Size:
    390 amino acids
    Molecular mass:
    43310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA58742.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};

    Alternative splice isoforms for PTGER3 Gene

neXtProt entry for PTGER3 Gene

Proteomics data for PTGER3 Gene at MOPED

Post-translational modifications for PTGER3 Gene

  • Glycosylation at Asn 18 and Asn 36
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for PTGER3

No data available for DME Specific Peptides for PTGER3 Gene

Domains & Families for PTGER3 Gene

Gene Families for PTGER3 Gene

Graphical View of Domain Structure for InterPro Entry

P43115

UniProtKB/Swiss-Prot:

PE2R3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER3: view

Function for PTGER3 Gene

Molecular function for PTGER3 Gene

GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).
genes like me logo Genes that share phenotypes with PTGER3: view

Animal Models for PTGER3 Gene

MGI Knock Outs for PTGER3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER3 Gene

Localization for PTGER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER3 Gene COMPARTMENTS Subcellular localization image for PTGER3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PTGER3: view

Pathways & Interactions for PTGER3 Gene

genes like me logo Genes that share pathways with PTGER3: view

SIGNOR curated interactions for PTGER3 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA --
GO:0006351 transcription, DNA-templated TAS 10336471
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007565 female pregnancy IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PTGER3: view

Drugs & Compounds for PTGER3 Gene

(41) Drugs for PTGER3 Gene - From: Novoseek, IUPHAR, DGIdb, Tocris, ApexBio, PharmGKB, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 129
Dinoprostone Approved Pharma antagonist, Target, agonist Major endogenous prostanoid 74
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 74
Misoprostol Approved Pharma Target, agonist 265
Treprostinil Approved, Investigational Pharma Full agonist, Agonist, agonist 77

(20) Additional Compounds for PTGER3 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-826266 (sodium salt)
Antagonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
sodium
  • Sodium
  • Sodium ion
7440-23-5
(+-)-Cloprostenol sodium salt
55028-72-3
U 46619
56985-40-1
genes like me logo Genes that share compounds with PTGER3: view

Drug Products

Transcripts for PTGER3 Gene

Unigene Clusters for PTGER3 Gene

Prostaglandin E receptor 3 (subtype EP3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - - -
SP7:

Relevant External Links for PTGER3 Gene

GeneLoc Exon Structure for
PTGER3
ECgene alternative splicing isoforms for
PTGER3

Expression for PTGER3 Gene

mRNA expression in normal human tissues for PTGER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER3 Gene

This gene is overexpressed in Uterus (x8.2), Adipose - Visceral (Omentum) (x5.2), Adipose - Subcutaneous (x5.1), and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for PTGER3 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGER3 Gene



SOURCE GeneReport for Unigene cluster for PTGER3 Gene Hs.445000

mRNA Expression by UniProt/SwissProt for PTGER3 Gene

P43115-PE2R3_HUMAN
Tissue specificity: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
genes like me logo Genes that share expression patterns with PTGER3: view

Protein tissue co-expression partners for PTGER3 Gene

Primer Products

In Situ Assay Products

Orthologs for PTGER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGER3 36
  • 88 (a)
OneToOne
PTGER3 35
  • 99.68 (n)
  • 99.52 (a)
cow
(Bos Taurus)
Mammalia PTGER3 36
  • 74 (a)
OneToOne
PTGER3 35
  • 86.43 (n)
  • 85.32 (a)
dog
(Canis familiaris)
Mammalia PTGER3 35
  • 88.95 (n)
  • 88.59 (a)
mouse
(Mus musculus)
Mammalia Ptger3 16
Ptger3 36
  • 80 (a)
OneToOne
Ptger3 35
  • 83.93 (n)
  • 86.53 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ptger3 35
  • 83.38 (n)
  • 85.97 (a)
chicken
(Gallus gallus)
Aves PTGER3 35
  • 77.11 (n)
  • 74.68 (a)
EP3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger3 35
  • 68.66 (n)
  • 69.4 (a)
zebrafish
(Danio rerio)
Actinopterygii ptger3 36
  • 53 (a)
OneToOne
LOC100000544 35
  • 61.69 (n)
  • 61.05 (a)
Species with no ortholog for PTGER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER3 Gene

ENSEMBL:
Gene Tree for PTGER3 (if available)
TreeFam:
Gene Tree for PTGER3 (if available)

Paralogs for PTGER3 Gene

Paralogs for PTGER3 Gene

genes like me logo Genes that share paralogs with PTGER3: view

Variants for PTGER3 Gene

Sequence variations from dbSNP and Humsavar for PTGER3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_014694 -
rs5694 - 70,974,342(-) CTTAC(A/C/T)CTGCC intron-variant, reference, missense
rs13306014 - 70,974,369(-) AAACA(A/G)CTATG intron-variant, reference, missense
rs13306020 - 71,012,426(-) ACACA(A/C/T)GGAGA nc-transcript-variant, reference, missense
rs5673 -- 71,012,158(-) AACCT(A/T)ACTGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PTGER3 Gene

Variant ID Type Subtype PubMed ID
nsv830148 CNV Gain 17160897
nsv871604 CNV Gain 21882294
esv994407 CNV Insertion 20482838
nsv871313 CNV Loss 21882294
nsv516212 CNV Loss 19592680
nsv871222 CNV Loss 21882294
nsv871141 CNV Loss 21882294
nsv461851 CNV Gain 19166990
dgv238n71 CNV Loss 21882294
nsv870734 CNV Loss 21882294
nsv871812 CNV Loss 21882294
nsv871242 CNV Loss 21882294
nsv871147 CNV Gain 21882294
esv2672048 CNV Deletion 23128226

Variation tolerance for PTGER3 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGER3 Gene

HapMap Linkage Disequilibrium report
PTGER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER3 Gene

Disorders for PTGER3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTGER3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
antenatal bartter syndrome
  • bartter syndrome, furosemide type
hypersensitivity syndrome, carbamazepine-induced
  • toxic epidermal necrolysis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTGER3

Genetic Association Database (GAD)
PTGER3
Human Genome Epidemiology (HuGE) Navigator
PTGER3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGER3
genes like me logo Genes that share disorders with PTGER3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER3 Gene

Publications for PTGER3 Gene

  1. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PMID: 9073510) Kotani M. … Nakao K. (Genomics 1997) 2 3 4 23 67
  2. Prostaglandin subtype-selective and non-selective IOP-lowering comparison in monkeys. (PMID: 19232013) Gabelt B.T. … Kaufman P.L. (J Ocul Pharmacol Ther 2009) 23 25 26
  3. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 3 23
  4. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman K.K. … Jacobsson B. (PLoS ONE 2010) 3 23
  5. Quantitative detection of EP3-II, III and VI messenger RNA in gravid and non-gravid human myometrium using real-time RT-PCR. (PMID: 19165680) Lee R.H. … Felix J.C. (J. Matern. Fetal. Neonatal. Med. 2009) 3 23

Products for PTGER3 Gene

Sources for PTGER3 Gene

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