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Aliases for PTGER2 Gene

Aliases for PTGER2 Gene

  • Prostaglandin E Receptor 2 2 3 5
  • Prostaglandin E Receptor 2 (Subtype EP2), 53kDa 2 3
  • Prostaglandin E Receptor 2 (Subtype EP2), 53kD 2 3
  • PGE2 Receptor EP2 Subtype 3 4
  • PGE Receptor EP2 Subtype 3 4
  • Prostanoid EP2 Receptor 3 4
  • Prostaglandin E2 Receptor EP2 Subtype 3
  • EP2 3

External Ids for PTGER2 Gene

Previous GeneCards Identifiers for PTGER2 Gene

  • GC14P050103
  • GC14P046577
  • GC14P050771
  • GC14P051850
  • GC14P052781
  • GC14P032941

Summaries for PTGER2 Gene

Entrez Gene Summary for PTGER2 Gene

  • This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

GeneCards Summary for PTGER2 Gene

PTGER2 (Prostaglandin E Receptor 2) is a Protein Coding gene. Diseases associated with PTGER2 include Asthma, Aspirin-Induced and Borderline Glaucoma. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGDR.

UniProtKB/Swiss-Prot for PTGER2 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Tocris Summary for PTGER2 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER2 Gene

Genomics for PTGER2 Gene

Regulatory Elements for PTGER2 Gene

Enhancers for PTGER2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F052324 1 FANTOM5 Ensembl ENCODE 24 +12.3 12254 5.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF143 PTGER2 GNG2 TXNDC16 GC14P052338
GH14F052311 1.4 FANTOM5 ENCODE 22.6 +1.2 1164 8.7 PKNOX1 INSM2 SIN3A BMI1 ZNF2 GLIS2 EGR1 ZNF366 FOS CREM PTGER2 LOC105370495 GNG2 TXNDC16 C14orf166 GC14P052338
GH14F052399 0.5 Ensembl ENCODE 19.3 +87.2 87164 3.9 CTCF PKNOX1 HLF CEBPB CEBPG RAD21 ZNF580 ZBTB20 PTGER2 GC14M052426 GC14P052338
GH14F052353 0.8 Ensembl ENCODE 17.3 +40.8 40827 2.6 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 FOS SP5 ZHX2 MIER2 PTGER2 GPR137C TXNDC16 GC14P052338 GC14M052426
GH14F052371 0.7 ENCODE 17.3 +56.5 56460 0.2 ZNF687 RFX1 MNT ZNF644 ZNF217 CTBP1 GATA3 KLF9 RCOR1 TCF7L2 PTGER2 GC14P052338 GC14M052426
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PTGER2 on UCSC Golden Path with GeneCards custom track

Promoters for PTGER2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001789196 902 5201 INSM2 SIN3A ZNF2 GLIS2 EGR1 ZNF366 CREM EGR2 SP3 ZEB2

Genomic Location for PTGER2 Gene

Chromosome:
14
Start:
52,314,298 bp from pter
End:
52,328,606 bp from pter
Size:
14,309 bases
Orientation:
Plus strand

Genomic View for PTGER2 Gene

Genes around PTGER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER2 Gene

Proteins for PTGER2 Gene

  • Protein details for PTGER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43116-PE2R2_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Protein Accession:
    P43116
    Secondary Accessions:
    • D3DSC0
    • Q52LG8

    Protein attributes for PTGER2 Gene

    Size:
    358 amino acids
    Molecular mass:
    39761 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTGER2 Gene

Post-translational modifications for PTGER2 Gene

  • Glycosylation at Asn 3, Asn 6, Asn 96, and Asn 287
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGER2 Gene

Domains & Families for PTGER2 Gene

Gene Families for PTGER2 Gene

Suggested Antigen Peptide Sequences for PTGER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43116

UniProtKB/Swiss-Prot:

PE2R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER2: view

Function for PTGER2 Gene

Molecular function for PTGER2 Gene

GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP2,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Gene Ontology (GO) - Molecular Function for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004957 prostaglandin E receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with PTGER2: view
genes like me logo Genes that share phenotypes with PTGER2: view

Animal Models for PTGER2 Gene

MGI Knock Outs for PTGER2:

Animal Model Products

miRNA for PTGER2 Gene

miRTarBase miRNAs that target PTGER2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER2 Gene

Localization for PTGER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER2 Gene COMPARTMENTS Subcellular localization image for PTGER2 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10462542
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTGER2: view

Pathways & Interactions for PTGER2 Gene

genes like me logo Genes that share pathways with PTGER2: view

SIGNOR curated interactions for PTGER2 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10462542
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA,ISS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA --
genes like me logo Genes that share ontologies with PTGER2: view

Drugs & Compounds for PTGER2 Gene

(61) Drugs for PTGER2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Misoprostol Approved Pharma Target, agonist 286
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 77
Alprostadil Approved, Investigational Pharma antagonist, Target, agonist Prostaglandin. Vasodilator and antiplatelet agent in vivo 69
Dinoprostone Approved Pharma antagonist, Target, agonist 88
Aspirin Approved, Vet_approved Pharma Channel blocker 1112

(28) Additional Compounds for PTGER2 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CP-544326
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist

(5) Tocris Compounds for PTGER2 Gene

Compound Action Cas Number
Alprostadil Prostaglandin. Vasodilator and antiplatelet agent in vivo 745-65-3
Iloprost Prostacyclin (PGI2) analog 78919-13-8
L-798,106 Potent and highly selective EP3 antagonist 244101-02-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(19) ApexBio Compounds for PTGER2 Gene

Compound Action Cas Number
(+)-Fluprostenol 54276-17-4
(±)-Cloprostenol sodium salt 55028-72-3
16,16-Dimethyl Prostaglandin E2 derivative of prostaglandin E2 39746-25-3
GW 627368 439288-66-1
L-161,982 147776-06-5
L-655,240 103253-15-2
L-670,596 121083-05-4
L-798,106 244101-02-8
Misoprostol 59122-46-2
NS 304 475086-01-2
PF 04418948 1078166-57-0
Pranoprofen 52549-17-4
Prostaglandin E2 activates the PGE2 receptor 363-24-6
Prostaglandin F2α 38562-01-5
SC 51089 146033-02-5
SC 51322 146032-79-3
Sulprostone 60325-46-4
TCS 2510 346673-06-1
U 46619 selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor 56985-40-1
genes like me logo Genes that share compounds with PTGER2: view

Drug Products

Transcripts for PTGER2 Gene

mRNA/cDNA for PTGER2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGER2 Gene

Prostaglandin E receptor 2 (subtype EP2), 53kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for PTGER2 Gene

GeneLoc Exon Structure for
PTGER2
ECgene alternative splicing isoforms for
PTGER2

Expression for PTGER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGER2 Gene

mRNA differential expression in normal tissues according to GTEx for PTGER2 Gene

This gene is overexpressed in Whole Blood (x12.4).

Protein differential expression in normal tissues from HIPED for PTGER2 Gene

This gene is overexpressed in Lung (55.8) and Peripheral blood mononuclear cells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGER2 Gene



Protein tissue co-expression partners for PTGER2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGER2 Gene:

PTGER2

SOURCE GeneReport for Unigene cluster for PTGER2 Gene:

Hs.2090

mRNA Expression by UniProt/SwissProt for PTGER2 Gene:

P43116-PE2R2_HUMAN
Tissue specificity: Placenta and lung.
genes like me logo Genes that share expression patterns with PTGER2: view

Primer Products

Orthologs for PTGER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGER2 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia PTGER2 34 35
  • 90.4 (n)
cow
(Bos Taurus)
Mammalia PTGER2 34 35
  • 87.22 (n)
mouse
(Mus musculus)
Mammalia Ptger2 34 16 35
  • 83.94 (n)
rat
(Rattus norvegicus)
Mammalia Ptger2 34
  • 83.9 (n)
oppossum
(Monodelphis domestica)
Mammalia PTGER2 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGER2 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGER2 34 35
  • 65.5 (n)
lizard
(Anolis carolinensis)
Reptilia PTGER2 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger2 34
  • 62.92 (n)
zebrafish
(Danio rerio)
Actinopterygii ptger2b 34 35
  • 51.85 (n)
ptger2a 35
  • 41 (a)
OneToMany
Species where no ortholog for PTGER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER2 Gene

ENSEMBL:
Gene Tree for PTGER2 (if available)
TreeFam:
Gene Tree for PTGER2 (if available)

Paralogs for PTGER2 Gene

Paralogs for PTGER2 Gene

(3) SIMAP similar genes for PTGER2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTGER2: view

Variants for PTGER2 Gene

Sequence variations from dbSNP and Humsavar for PTGER2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10136396 -- 52,318,873(+) TTATC(A/G)ACCAC intron-variant
rs10136414 -- 52,318,929(+) TCACA(A/G)CACCG intron-variant
rs10138549 -- 52,315,761(+) ATGGC(G/T)GTCAC intron-variant, upstream-variant-2KB
rs10142554 -- 52,313,532(+) AACAC(A/G)ATTCT nc-transcript-variant, upstream-variant-2KB
rs10142849 -- 52,320,837(+) GGATC(A/G)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGER2 Gene

Variant ID Type Subtype PubMed ID
esv3634521 CNV gain 21293372
nsv832795 CNV gain 17160897

Variation tolerance for PTGER2 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGER2 Gene

Human Gene Mutation Database (HGMD)
PTGER2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER2 Gene

Disorders for PTGER2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTGER2 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma, aspirin-induced
  • asthma and nasal polyps
borderline glaucoma
  • preglaucoma
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTGER2

Genetic Association Database (GAD)
PTGER2
Human Genome Epidemiology (HuGE) Navigator
PTGER2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGER2
genes like me logo Genes that share disorders with PTGER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER2 Gene

Publications for PTGER2 Gene

  1. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole E.M. … Ulrich C.M. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 22 46 64
  2. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 3 22 64
  3. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. (PMID: 8078484) Regan J.W. … Gil D.W. (Mol. Pharmacol. 1994) 3 4 22 64
  4. Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. (PMID: 8250933) An S. … Goetzl E.J. (Biochem. Biophys. Res. Commun. 1993) 2 3 22 64
  5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman K.K. … Jacobsson B. (PLoS ONE 2010) 3 46 64

Products for PTGER2 Gene

Sources for PTGER2 Gene

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