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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTGER2 Gene

protein-coding GIFtS: 66
GCID: GC14P052781

prostaglandin E receptor 2 (subtype EP2), 53kDa

(Previous names: prostaglandin E receptor 2 (subtype EP2), 53kD )

Explore 64 diseases affiliated with
PTGER2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Prostaglandin E Receptor 2 (Subtype EP2), 53kDa¹ ²		PGE2 Receptor EP2 Subtype² ³
EP2¹ ²		Prostaglandin E Receptor 2 (Subtype EP2), 53kD¹
Prostanoid EP2 Receptor² ³		Prostaglandin E2 Receptor EP2 Subtype²
PGE Receptor EP2 Subtype² ³

External Ids:	HGNC: 9594¹	Entrez Gene: 5732²	Ensembl: ENSG00000125384⁷	OMIM: 176804⁵	UniProtKB: P43116³

Export aliases for PTGER2 gene to outside databases

Previous GC identifers: GC14P050103 GC14P046577 GC14P050771 GC14P051850 GC14P032941

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGER2:

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic

activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to

asthma. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: PE2R2_HUMAN, P43116

Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that

stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this

receptor on smooth muscle

summary for PTGER2:

Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,

prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which

the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled

receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of

prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle

contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory

receptor that prevents smooth muscle relaxation.

Gene Wiki entry for PTGER2 (Prostaglandin E2 receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTGER2 gene promoter:
TBP Nkx2-2 Pax-2 Pax-2a Max Pax-2b TFIID Sox9 ZIC2/Zic2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTGER2 promoter sequence

Search SABiosciences Chromatin IP Primers for PTGER2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGER2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q22

PTGER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGER2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P052781: view genomic region (about GC identifiers)

Start:	52,781,016 bp from pter	End:	52,795,324 bp from pter
Size:	14,309 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PE2R2_HUMAN, P43116 (See protein sequence)

Recommended Name: Prostaglandin E2 receptor EP2 subtype

Size: 358 amino acids; 39761 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: D3DSC0 Q52LG8

Explore the universe of human proteins at neXtProt for PTGER2: NX_P43116

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P43116

PTGER2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000947.2

ENSEMBL proteins:

ENSP00000450933 ENSP00000245457

Reactome Protein details: P43116
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PTGER2 Protein
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	Novus Biologicals PTGER2 Protein Novus Biologicals PTGER2 Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PTGER2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	10462542
GO:0016021	integral to membrane	--	--

PTGER2 for ontologies About GeneDecksing

PTGER2 Antibody Products:

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	ThermoFisher Antibodies for PTGER2

Assay Products for PTGER2:

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	GenScript PTGER2-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PTGER2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTGER2 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR008365 Prostanoid_rcpt

IPR001923 Prostglndn_EP2_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P43116

ProtoNet protein and cluster: P43116

1 Blocks protein family: IPB001923 Prostanoid EP2 receptor signature

UniProtKB/Swiss-Prot: PE2R2_HUMAN, P43116

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PE2R2_HUMAN, P43116

Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that

stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this

receptor on smooth muscle

Genatlas biochemistry entry for PTGER2:

prostaglandin E2 receptor,subtype EP2,G protein coupled receptor superfamily,expressed in peripheral leukocytes with

alternatively transcripts in spleen and thymus

miRNA Products:		OriGene 3'-UTR Clone: PTGER2 Browse MicroRNA Expression Plasmids
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		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGER2 (see all 20):
		hsa-miR-4328 hsa-miR-429 hsa-miR-421 hsa-miR-515-5p hsa-miR-141* hsa-miR-7-1* hsa-miR-205* hsa-miR-1183

		SwitchGear 3'UTR luciferase reporter plasmid: PTGER2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGER2 (see all 7) OriGene shRNA RFP: PTGER2 OriGene siRNA: PTGER2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PTGER2

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		GenScript: all cDNA clones in your preferred vector: PTGER2 (NM_000956)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGER2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004957	prostaglandin E receptor activity	IEA	--

PTGER2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PTGER2:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for PTGER2: Ptger2^tm1Bhk Ptger2^tm1Rsz Ptger2^tm2Bhk Ptger2^tm1Brey Ptger2^tm1Sna
15/18 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ptger2) (see all 18):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	integument	mortality/aging	muscle
nervous system	no phenotypic analysis	other	renal/urinary system	reproductive system

PTGER2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Prostanoid ligand receptors

	Prostanoid ligand receptors	1.00			Small Ligand GPCRs	0.42
	Eicosanoid ligand-binding receptors	0.60

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

PKA activation in glucagon signalling

Neurophysiological process PGE2-induced pain processing

0.44

Neurophysiological process_PGE2-induced pain processing

0.44

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PTGER2

Neurophysiological process PGE2-induced pain processing

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PTGER2

Colorectal Cancer Metastasis

1 GeneGo (Thomson Reuters) Pathway for PTGER2

Neurophysiological process PGE2-induced pain processing

4 BioSystems Pathways for PTGER2

	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Ovarian Infertility Genes
	Small Ligand GPCRs

5/8 Reactome Pathways for PTGER2 (see all 8)

	GPCR downstream signaling
	Eicosanoid ligand-binding receptors
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)

2 PharmGKB Pathways for PTGER2

	Celecoxib Pathway, Pharmacodynamics
	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for PTGER2):

Neuroactive ligand-receptor interaction

PTGER2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTGER2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/67 Interacting proteins for PTGER2 (P43116³ ENSP00000245457⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 67)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTGES	O14684³, ENSP00000342385⁴	I2D: score=1 STRING: ENSP00000342385
PTGDS	P41222³, ENSP00000360687⁴	I2D: score=1 STRING: ENSP00000360687
PTGFR	P43088³, ENSP00000359793⁴	I2D: score=1 STRING: ENSP00000359793
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	TAS	10462542
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	ISS	--
GO:0032496	response to lipopolysaccharide	IEA	--
GO:0042127	regulation of cell proliferation	IEA	--
GO:0071380	cellular response to prostaglandin E stimulus	ISS	--

PTGER2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTGER2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PTGER2 available from Tocris Bioscience About this table

Compound	Action	CAS #
16,16-Dimethyl Prostaglandin E2	Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development	[39746-25-3]
Alprostadil	Prostaglandin. Vasodilator and antiplatelet agent in vivo	[745-65-3]
AH 6809	EP1 and EP2 receptor antagonist	[33458-93-4]
Prostaglandin E2	Major endogenous prostanoid	[363-24-6]

2 HMDB Compounds for PTGER2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Prostaglandin E2	(-)-Prostaglandin E2 (see all 22)	363-24-6	--

3 DrugBank Compounds for PTGER2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dinoprostone	Dinoprostone Prostaglandin E2 (see all 3)	363-24-6	target	agonist	18715952 19788928 20599704 11752352 17329241
Misoprostol	--	59122-46-2	target	agonist	16039053 18472336 11602631 12097143 9313928
Alprostadil	--	745-65-3	target	agonist	10509658 11752352 15840408

10/50 Novoseek chemical compound relationships for PTGER2 gene (see all 50) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
butaprost	96.9	52	16262658 (2), 8590276 (2), 18597941 (2), 12724323 (1) (see all 41)
sulprostone	93.4	15	16168007 (1), 7532011 (1), 9531979 (1), 15464062 (1) (see all 15)
pge2	93	309	14751245 (4), 15746982 (4), 10697805 (4), 12738687 (4) (see all 99)
11-deoxy-pge1	92	11	8435410 (1), 9531979 (1), 12753465 (1), 15290741 (1) (see all 9)
ah 6809	91.8	5	19539567 (1), 12429018 (1), 16020747 (1), 16456101 (1)
ah23848	89.3	1	9888433 (1)
gr 63799x	88.3	2	15464062 (1), 8641211 (1)
prostaglandin	87.3	51	19570035 (2), 8078484 (2), 8590276 (2), 12228765 (1) (see all 33)
pge1 alcohol	86.8	1	15769457 (1)
17-phenyl-trinor-pge2	85.7	2	16516814 (1)

Search CenterWatch for drugs/clinical trials and news about PTGER2 / PE2R2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTGER2 gene:

NM_000956.3

Unigene Cluster for PTGER2:

Prostaglandin E receptor 2 (subtype EP2), 53kDa

Hs.2090 [show with all ESTs]

Unigene Representative Sequence: NM_000956

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000557436 ENST00000245457(uc001wzr.3)

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		hsa-miR-4328 hsa-miR-429 hsa-miR-421 hsa-miR-515-5p hsa-miR-141* hsa-miR-7-1* hsa-miR-205* hsa-miR-1183

		SwitchGear 3'UTR luciferase reporter plasmid: PTGER2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: PTGER2 (NM_000956)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGER2

Additional cDNA sequence:

AY275471.1 BC093927.1 BC093929.1 U19487.1 X83868.1

3 DOTS entries:

DT.409452 DT.120773770 DT.95357797

1 AceView cDNA sequence:

BF029797

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for PTGER2 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:

ECgene alternative splicing isoforms for PTGER2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTGER2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATGTAAA

About this image

PTGER2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Kidney

Glomerulus

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Mast-like cells (Generation of hemato...)

See PTGER2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTGER2

SOURCE GeneReport for Unigene cluster: Hs.2090

UniProtKB/Swiss-Prot: PE2R2_HUMAN, P43116

Tissue specificity: Placenta and lung

SABiosciences Expression via Pathway-Focused PCR Arrays including PTGER2:

G Protein Coupled Receptors 384HT in human mouse rat

Neurotrophins & Receptors in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGER2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTGER2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PTGER2¹	prostaglandin E receptor 2 (subtype EP2), 53kDa	65.69(n) 61.7(a)		100034745 NM_001083365.1 NP_001076834.1
lizard (Anolis carolinensis)	Reptilia	PTGER2⁶	--	47(a)	1 ↔ 1	AAWZ02038448(7803-10385)
zebrafish (Danio rerio)	Actinopterygii	ptger2b¹	prostaglandin E receptor 2b (subtype EP2)	52.29(n) 49.67(a)		570410 NM_001030250.1 NP_001025421.1
fruit fly (Drosophila melanogaster)	Insecta	CG7497⁶	--	14(a)	possible ortholog	3L(17626549-17630975)

ENSEMBL Gene Tree for PTGER2 (if available)
TreeFam Gene Tree for PTGER2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTGER2 gene

PTGDR² PTGER1² PTGER4² PTGER3² PTGFR² TBXA2R² PTGIR²

3 SIMAP similar genes for PTGER2 using alignment to 2 protein entries: PE2R2_HUMAN (see all proteins):

PTGDR PTGIR PTGER4

PTGER2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs45464795^1,2	C,F,	--	32939624(+)	`TGTGAG/AGGGCC`	1	--	us2k¹		5		NS NA WA	332
rs45542938^1,2	C,	--	32939741(+)	`CTATAA/CATCAT`	1	--	us2k¹		2		NS	90
rs45614637^1,2	C,	--	32939748(+)	`TCATAG/CTGTTT`	1	--	us2k¹		3		NS WA	208
rs28600795^1,2	C,F,	--	32940036(+)	`CTTGTT/CCTAGT`	1	--	us2k¹		5		NS NA WA	212
rs35531840^1,2	C	--	32940052(+)	`MCCCCC/ACCCAA`	1	--	us2k¹		1		NA	2
rs10142554^1,2	C,F,	--	32940575(+)	`AACACA/GATTCT`	1	--	us2k¹		6		NS NA WA	210
rs45487500^1,2	C,F,	--	32940625(+)	`CAAGTG/AGTTAT`	1	--	us2k¹		5		NS CSA WA NA	326
rs112079923^1,2		--	32940744(+)	`GACACG/ACTTGC`	1	--	us2k¹		1		CSA	2
rs79240096^1,2		--	32940825(+)	`AACATT/CCTGGT`	1	--	us2k¹		3		CSA WA NA	240
rs34757697^1,2		--	32941077(+)	`GAAACA/GCCGCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTGER2 (52781016 - 52795324 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PTGER2: --
Human Gene Mutation Database (HGMD): PTGER2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PTGER2 for disorders           About GeneDecksing

OMIM gene information: 176804
OMIM disorders: 208550
20/64 diseases for PTGER2 (see all 64):    About MalaCards

asthma, aspirin-induced spinal cord injury asthma familial adenomatous polyposis

patent ductus arteriosus amyotrophic lateral sclerosis lateral sclerosis ocular hypotension

barrett's esophagus keshan disease esophageal squamous cell carcinoma squamous cell carcinoma

gastric ulcer neurodegenerative disease herpes simplex polyposis

periodontal disease endometrial carcinoma essential hypertension periodontitis

1 disease from the University of Copenhagen DISEASES database for PTGER2:

Keshan disease

10/24 Novoseek disease relationships for PTGER2 gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
intestinal polyps	40.2	3	11533709 (2), 15247185 (1)
colon cancer	33.7	6	15247185 (2), 17555711 (1), 16293724 (1), 19050969 (1)
inflammation	32.1	6	18825663 (2), 15496426 (1), 12566441 (1), 20200425 (1) (see all 5)
periodontal diseases	24.3	1	10697805 (1)
necrosis	18.6	2	10697805 (1), 12586778 (1)
tumors	17.7	17	14751245 (1), 18790761 (1), 10697805 (1), 17533365 (1) (see all 11)
carcinoma non-small cell lung	11.6	1	14751245 (1)
lung carcinoma	7.37	3	14751245 (3)
amyotrophic lateral sclerosis	2.56	1	18825663 (1)
cancer	0.862	2	12566441 (1), 15247185 (1)

Human Genome Epidemiology (HuGE) Navigator: PTGER2 (20 documents)

Export disorders for PTGER2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PTGER2 gene, integrated from 9 sources (see all 360):
(articles sorted by number of sources associating them with PTGER2)

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Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. (PubMed id 8078484)^{1, 2, 9} Regan J.W.... Gil D.W. (1994)
Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. (PubMed id 8250933)^{1, 3, 9} An S.... Goetzl E.J. (1993)
Chromosomal localization of the human prostanoid receptor gene family. (PubMed id 7759114)^{1, 3, 9} Duncan A.M....Adam M. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype. (PubMed id 10521663)^{1, 2} Smock S.L.... Owen T.A. (1999)
Prognostic role of PGE2 receptor EP2 in esophageal squamous cell carcinoma. (PubMed id 19050969)^{1, 9} Kuo K.T....Wang L.S. (2009)
Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas. (PubMed id 17533365)^{1, 9} Sugino Y....Inazawa J. (2007)
Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines. (PubMed id 12228765)^{1, 9} Okuyama T....Kinoshita Y. (2002)
Identification of transcriptional targets of Wnt/beta -catenin signaling in dermal papilla cells of human scalp hair follicles: EP2 i s a novel transcriptional target of Wnt3a. (PubMed id 20347274)^{1, 9} Shin H....Sung Y.K. (2010)
Prostaglandin E2 differentially modulates proinflamma tory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP. (PubMed id 19542367)^{1, 9} Kunisch E....Kinne R.W. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5732	HGNC: 9594	AceView: PTGER2.1	Ensembl:ENSG00000125384	euGenes: HUgn5732
ECgene: PTGER2	Kegg: 5732	H-InvDB: PTGER2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PTGER2	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/ptger2/

Intellectual Property for PTGER2 gene
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Patent Information for PTGER2 gene:
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GeneCards and IP:
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prostaglandin E receptor 2 (subtype EP2), 53kDa

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PTGER2 Gene

prostaglandin E receptor 2 (subtype EP2), 53kDa

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