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Aliases for PTGER2 Gene

Aliases for PTGER2 Gene

  • Prostaglandin E Receptor 2 (Subtype EP2), 53kDa 2 3
  • Prostaglandin E Receptor 2 (Subtype EP2), 53kD 2 3
  • PGE2 Receptor EP2 Subtype 3 4
  • PGE Receptor EP2 Subtype 3 4
  • Prostanoid EP2 Receptor 3 4
  • EP2 3

External Ids for PTGER2 Gene

Previous GeneCards Identifiers for PTGER2 Gene

  • GC14P050103
  • GC14P046577
  • GC14P050771
  • GC14P051850
  • GC14P052781
  • GC14P032941

Summaries for PTGER2 Gene

Entrez Gene Summary for PTGER2 Gene

  • This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

GeneCards Summary for PTGER2 Gene

PTGER2 (Prostaglandin E Receptor 2 (Subtype EP2), 53kDa) is a Protein Coding gene. Diseases associated with PTGER2 include asthma, aspirin-induced and colorectal cancer. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGER2 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle

Tocris Summary for PTGER2 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER2 Gene

Genomics for PTGER2 Gene

Regulatory Elements for PTGER2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PTGER2 Gene

Chromosome:
14
Start:
52,314,298 bp from pter
End:
52,328,606 bp from pter
Size:
14,309 bases
Orientation:
Plus strand

Genomic View for PTGER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER2 Gene

Proteins for PTGER2 Gene

  • Protein details for PTGER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43116-PE2R2_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Protein Accession:
    P43116
    Secondary Accessions:
    • D3DSC0
    • Q52LG8

    Protein attributes for PTGER2 Gene

    Size:
    358 amino acids
    Molecular mass:
    39761 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTGER2 Gene

Proteomics data for PTGER2 Gene at MOPED

Post-translational modifications for PTGER2 Gene

  • Glycosylation at Asn 3, Asn 6, Asn 96, and Asn 287
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTGER2 Gene

Domains & Families for PTGER2 Gene

Gene Families for PTGER2 Gene

Suggested Antigen Peptide Sequences for PTGER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43116

UniProtKB/Swiss-Prot:

PE2R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER2: view

Function for PTGER2 Gene

Molecular function for PTGER2 Gene

GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP2,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle

Gene Ontology (GO) - Molecular Function for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004957 prostaglandin E receptor activity IEA --
genes like me logo Genes that share ontologies with PTGER2: view
genes like me logo Genes that share phenotypes with PTGER2: view

Animal Models for PTGER2 Gene

MGI Knock Outs for PTGER2:

Animal Model Products

CRISPR Products

miRNA for PTGER2 Gene

miRTarBase miRNAs that target PTGER2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGER2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PTGER2 Gene

Localization for PTGER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER2 Gene COMPARTMENTS Subcellular localization image for PTGER2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10462542
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PTGER2: view

Pathways & Interactions for PTGER2 Gene

genes like me logo Genes that share pathways with PTGER2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PTGER2 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 10462542
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS --
GO:0032496 response to lipopolysaccharide IEA --
GO:0032570 response to progesterone IEA --
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with PTGER2: view

Drugs & Compounds for PTGER2 Gene

(44) Drugs for PTGER2 Gene - From: IUPHAR, DGIdb, Tocris, NovoSeek, HMDB, DrugBank, PharmGKB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 73
Dinoprostone Approved Pharma antagonist, Target, agonist 67
Misoprostol Approved Pharma Target, agonist 244
Alprostadil Approved, Investigational Pharma antagonist, Target, agonist 57
Aspirin Approved Pharma Channel blocker 971

(33) Additional Compounds for PTGER2 Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CP-544326
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
(+-)-Cloprostenol sodium salt
55028-72-3
Ozagrel hydrochloride
74003-18-2
U 46619
56985-40-1
genes like me logo Genes that share compounds with PTGER2: view

Drug Products

Transcripts for PTGER2 Gene

mRNA/cDNA for PTGER2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGER2 Gene

Prostaglandin E receptor 2 (subtype EP2), 53kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGER2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for PTGER2 Gene

GeneLoc Exon Structure for
PTGER2
ECgene alternative splicing isoforms for
PTGER2

Expression for PTGER2 Gene

mRNA expression in normal human tissues for PTGER2 Gene

mRNA differential expression in normal tissues according to GTEx for PTGER2 Gene

This gene is overexpressed in Whole Blood (x12.4).

Protein differential expression in normal tissues from HIPED for PTGER2 Gene

This gene is overexpressed in Lung (55.8) and Peripheral blood mononuclear cells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGER2 Gene



SOURCE GeneReport for Unigene cluster for PTGER2 Gene Hs.2090

mRNA Expression by UniProt/SwissProt for PTGER2 Gene

P43116-PE2R2_HUMAN
Tissue specificity: Placenta and lung
genes like me logo Genes that share expression patterns with PTGER2: view

Protein tissue co-expression partners for PTGER2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PTGER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGER2 35
  • 87.22 (n)
  • 85.23 (a)
PTGER2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGER2 35
  • 90.4 (n)
  • 88.98 (a)
PTGER2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptger2 35
  • 83.94 (n)
  • 87.39 (a)
Ptger2 16
Ptger2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTGER2 35
  • 99.35 (n)
  • 98.6 (a)
PTGER2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptger2 35
  • 83.9 (n)
  • 85.23 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGER2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGER2 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGER2 35
  • 65.5 (n)
  • 60.23 (a)
PTGER2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER2 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger2 35
  • 62.92 (n)
  • 58.12 (a)
zebrafish
(Danio rerio)
Actinopterygii ptger2b 35
  • 51.85 (n)
  • 48.69 (a)
ptger2a 36
  • 41 (a)
OneToMany
ptger2b 36
  • 45 (a)
OneToMany
Species with no ortholog for PTGER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER2 Gene

ENSEMBL:
Gene Tree for PTGER2 (if available)
TreeFam:
Gene Tree for PTGER2 (if available)

Paralogs for PTGER2 Gene

Paralogs for PTGER2 Gene

(3) SIMAP similar genes for PTGER2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTGER2: view

Variants for PTGER2 Gene

Sequence variations from dbSNP and Humsavar for PTGER2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs17197 -- 52,327,663(-) GCTCA(C/T)TGAGG utr-variant-3-prime
rs708498 -- 52,325,782(+) CCGGC(A/G)TAAAC intron-variant
rs708499 -- 52,326,558(-) TAATG(A/G)ACCTT intron-variant
rs708500 -- 52,326,581(-) TGAGA(C/T)CAATG intron-variant
rs708501 -- 52,326,665(-) ACAGG(G/T)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGER2 Gene

Variant ID Type Subtype PubMed ID
nsv832795 CNV Gain 17160897

Variation tolerance for PTGER2 Gene

Residual Variation Intolerance Score: 21.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGER2 Gene

HapMap Linkage Disequilibrium report
PTGER2
Human Gene Mutation Database (HGMD)
PTGER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER2 Gene

Disorders for PTGER2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTGER2 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
asthma, aspirin-induced
  • asthma and nasal polyps
colorectal cancer
  • colorectal cancer, somatic
- elite association

Relevant External Links for PTGER2

Genetic Association Database (GAD)
PTGER2
Human Genome Epidemiology (HuGE) Navigator
PTGER2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGER2
genes like me logo Genes that share disorders with PTGER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER2 Gene

Publications for PTGER2 Gene

  1. Flow after prostaglandin E1 is mediated by receptor-coupled adenylyl cyclase in human anterior segments. (PMID: 10509658) Dijkstra B.G. … Hoyng P.F. (Invest. Ophthalmol. Vis. Sci. 1999) 23 25 67
  2. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan A.M. … Adam M. (Genomics 1995) 2 23 67
  3. Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. (PMID: 8250933) An S. … Goetzl E.J. (Biochem. Biophys. Res. Commun. 1993) 2 23 67
  4. Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear. (PMID: 20219142) Hori R. … Ito J. (BMC Neurosci 2010) 23 67
  5. Identification of transcriptional targets of Wnt/beta-catenin signaling in dermal papilla cells of human scalp hair follicles: EP2 is a novel transcriptional target of Wnt3a. (PMID: 20347274) Shin H. … Sung Y.K. (J. Dermatol. Sci. 2010) 23 67

Products for PTGER2 Gene

Sources for PTGER2 Gene

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