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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PTGER1 Gene

protein-coding GIFtS: 61
GCID: GC19M014583

prostaglandin E receptor 1 (subtype EP1), 42kDa

(Previous names: prostaglandin E receptor 1 (subtype EP1), 42kD )

Explore 40 diseases affiliated with
PTGER1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Prostaglandin E Receptor 1 (Subtype EP1), 42kDa¹ ²		Prostaglandin E Receptor 1 (Subtype EP1), 42kD¹
EP1¹ ²		PGE Receptor, EP1 Subtype²
Prostanoid EP1 Receptor² ³		Prostaglandin E Receptor 1, Subtype EP1²
PGE Receptor EP1 Subtype² ³		Prostaglandin E2 Receptor EP1 Subtype²
PGE2 Receptor EP1 Subtype² ³

External Ids:	HGNC: 9593¹	Entrez Gene: 5731²	Ensembl: ENSG00000160951⁷	OMIM: 176802⁵	UniProtKB: P34995³

Export aliases for PTGER1 gene to outside databases

Previous GC identifers: GC19M014938 GC19M014428 GC19M014444 GC19M014153

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGER1:

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four

receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q

proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating

algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate

adrenocorticotropic hormone response to bacterial endotoxin. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PE2R1_HUMAN, P34995

Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which

activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal

function. Implicated the smooth muscle contractile response to PGE2 in various tissues

summary for PTGER1:

Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,

prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which

the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled

receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of

prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle

contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory

receptor that prevents smooth muscle relaxation.

Gene Wiki entry for PTGER1 (EP1 receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PTGER1 gene promoter:
HOXA9B HOXA9 SRF Elk-1 SRF (504 AA) Egr-1 STAT5A Meis-1b ZID Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PTGER1 promoter sequence

Search SABiosciences Chromatin IP Primers for PTGER1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGER1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.1

PTGER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGER1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M014583: view genomic region (about GC identifiers)

Start:	14,583,278 bp from pter	End:	14,586,174 bp from pter
Size:	2,897 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PE2R1_HUMAN, P34995 (See protein sequence)

Recommended Name: Prostaglandin E2 receptor EP1 subtype

Size: 402 amino acids; 41801 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAC05723.1; Type=Erroneous gene model prediction;

Secondary accessions: Q5U5U4 Q86UH3 Q86VB5 Q8NHB2

Explore the universe of human proteins at neXtProt for PTGER1: NX_P34995

Post-translational modifications:

Phosphorylated (Potential)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P34995

PTGER1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000946.2

ENSEMBL proteins:

ENSP00000292513

Reactome Protein details: P34995
Human Recombinant Protein Products:

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	Uscn Proteins for PTGER1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8253813

PTGER1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PTGER1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PTGER1 for domains About GeneDecksing

5 InterPro domains/families:

IPR000708 Prostglndn_EP1_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR008365 Prostanoid_rcpt

IPR000276 GPCR_Rhodpsn

IPR001244 Prostglndn_DP_rcpt

Graphical View of Domain Structure for InterPro Entry P34995

ProtoNet protein and cluster: P34995

2 Blocks protein families:

IPB000708 Prostanoid EP1 receptor signature

IPB001244 Prostaglandin receptor signature

UniProtKB/Swiss-Prot: PE2R1_HUMAN, P34995

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PE2R1_HUMAN, P34995

Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which

activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal

function. Implicated the smooth muscle contractile response to PGE2 in various tissues

Genatlas biochemistry entry for PTGER1:

prostaglandin E2 receptor,subtype EP1 (42kDa),G protein coupled receptor superfamily

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PTGER1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004957	prostaglandin E receptor activity	IEA	--

PTGER1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for PTGER1: Ptger1^tm1Jdm Ptger1^tm1Sna Ptger1^tm1Crjk
     13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ptger1):

behavior/neurological	cardiovascular system	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	mortality/aging	nervous system
renal/urinary system	reproductive system	tumorigenesis

PTGER1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Prostanoid ligand receptors

	Prostanoid ligand receptors	1.00			Small Ligand GPCRs	0.42
	Eicosanoid ligand-binding receptors	0.60

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Celecoxib Pathway, Pharmacodynamics

Celecoxib Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for PTGER1

	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs

5/9 Reactome Pathways for PTGER1 (see all 9)

	GPCR downstream signaling
	Eicosanoid ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

1 PharmGKB Pathway for PTGER1

Celecoxib Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for PTGER1):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction

PTGER1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PTGER1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/128 Interacting proteins for PTGER1 (P34995³ ENSP00000292513⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 128)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTGES	O14684³, ENSP00000342385⁴	I2D: score=1 STRING: ENSP00000342385
PTGDS	P41222³, ENSP00000360687⁴	I2D: score=2 STRING: ENSP00000360687
PTGER3	P43115³, ENSP00000349003⁴	I2D: score=1 STRING: ENSP00000349003
PTGFR	P43088³, ENSP00000359793⁴	I2D: score=1 STRING: ENSP00000359793
BDKRB1	ENSP00000216629⁴	STRING: ENSP00000216629

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8253813
GO:0032496	response to lipopolysaccharide	IEA	--

PTGER1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PTGER1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PTGER1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Alprostadil	Prostaglandin. Vasodilator and antiplatelet agent in vivo	[745-65-3]
SC 19220	Selective EP1 receptor antagonist	[19395-87-0]
AH 6809	EP1 and EP2 receptor antagonist	[33458-93-4]
Prostaglandin E2	Major endogenous prostanoid	[363-24-6]
SC 51089	Selective EP1 receptor antagonist	[146033-02-5]

2 HMDB Compounds for PTGER1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Prostaglandin E2	(-)-Prostaglandin E2 (see all 22)	363-24-6	--

6 DrugBank Compounds for PTGER1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alprostadil	--	745-65-3	target	agonist	15560119 14561849 11524243 16516814 10670413
Carboprost Tromethamine	--	58551-69-2	target	agonist	20519365 9462300 17016423 11338376
Dinoprostone	Dinoprostone Prostaglandin E2 (see all 3)	363-24-6	target	agonist	18715952 19788928 20599704 17329241
Bupivacaine	(+-)-Bupivacaine (see all 10)	2180-92-9	target	other/unknown	17139284 19690271 17016423
Bimatoprost	--	155206-00-1	target	agonist	16877408 14733708
Iloprost	--	78919-13-8	target	agonist	11999132 11739243

10/37 Novoseek chemical compound relationships for PTGER1 gene (see all 37) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
butaprost	96.2	12	9530435 (1), 14981131 (1), 15888106 (1), 15640521 (1) (see all 8)
sulprostone	93.4	20	9537820 (2), 10602330 (1), 7606349 (1), 7532011 (1) (see all 16)
17-phenyl-trinor-pge2	92.9	17	10623883 (2), 11850210 (1), 11133502 (1), 7970215 (1) (see all 9)
11-deoxy-pge1	92.6	1	9362328 (1)
gr 63799x	90.7	3	15464062 (1), 7535849 (1), 8641211 (1)
pge2	90.6	165	20035770 (4), 11445823 (3), 9877447 (3), 17370287 (3) (see all 89)
ah 6809	89.3	8	15015658 (2), 9530435 (1), 8149238 (1), 15501405 (1) (see all 7)
prostaglandin	84.5	27	18079197 (1), 7532011 (1), 11478765 (1), 12478616 (1) (see all 17)
ah23848	77.9	1	9888433 (1)
sc19220	77.5	1	15501405 (1)

Search CenterWatch for drugs/clinical trials and news about PTGER1 / PE2R1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PTGER1 gene:

NM_000955.2

Unigene Cluster for PTGER1:

Prostaglandin E receptor 1 (subtype EP1), 42kDa

Hs.159360 [show with all ESTs]

Unigene Representative Sequence: BM919091

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000292513(uc002mys.3)

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Additional cDNA sequence:

AY275470.1 BC029768.1 BC039034.1 BC051286.1 L22647.1

1 DOTS entry:

DT.40279463

24/57 AceView cDNA sequences (see all 57):

AI522201 BF115139 NM_000955 AW299490 BM127301 CK906197 AW000941 CK906196

BC039034 BM127603 BC051286 BF197413 AY275470 AW015286 AW001764 BF511364

AI627838 BF515800 AW269162 AI953039 L22647 AI796157 AI762344 AI935642

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PTGER1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGTGGAGC

About this image

PTGER1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Mast-like cells (Generation of hemato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PTGER1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PTGER1

SOURCE GeneReport for Unigene cluster: Hs.159360

UniProtKB/Swiss-Prot: PE2R1_HUMAN, P34995

Tissue specificity: Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression

in testis and not detected in liver brain and heart

SABiosciences Expression via Pathway-Focused PCR Array including PTGER1:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PTGER1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PTGER1 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	PTGER1⁶	--	56(a)	1 ↔ 1	2(102556333-102558359)
zebrafish (Danio rerio)	Actinopterygii	ptger1b¹	prostaglandin E receptor 1b (subtype EP1)	55.29(n) 52.57(a)		564945 NM_001166333.1 NP_001159805.1
fruit fly (Drosophila melanogaster)	Insecta	CG7497⁶	--	17(a)	possible ortholog	3L(17626549-17630975)

ENSEMBL Gene Tree for PTGER1 (if available)
TreeFam Gene Tree for PTGER1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PTGER1 gene

PTGDR² PTGER4² PTGER3² PTGFR² PTGER2² TBXA2R² PTGIR²

1 SIMAP similar gene for PTGER1 using alignment to 2 protein entries: PE2R1_HUMAN (see all proteins):

PTGFR

PTGER1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28364033^1,2	C,	--	14583219(-)	`CGGGGG/AGCTGC`	1	--	ds500¹		4		CSA WA	207
rs2241363^1,2	C,F,H,	--	14583264(-)	`AGGACA/C/GGTGTG`	1	--	ds500¹		10		EA NA CSA WA	1745
rs61623859^1,2	C,	--	14583363(+)	`GCCTCC/TGGTTG`	1	--	ut3¹		0	--	--	--	--
rs200448909^1,2		--	14583537(+)	`ACCCAA/TGGGTC`	2	P	syn¹		0	--	--	--	--
rs11668633^1,2	C,F,A,H,	--	14583582(+)	`AGGAAC/TAGTGG`	2	L	syn¹		19		NS EA NA	4414
rs202117617^1,2	C,	--	14583589(+)	`GTGGCC/GGCTGC`	2	P R	mis¹		0	--	--	--	--
rs201132257^1,2		--	14583618(+)	`CCGCCA/GACGGC`	2	V	syn¹		0	--	--	--	--
rs10419296^1,2	C,F,	--	14583684(+)	`CGCAGA/C/GGGGGC`	1	--	int¹		2		WA	202
rs28364036^1,2	F	--	14583737(-)	`CTCGCC/TCCTCC`	1	--	int¹ trp³		1		--	82
rs2241362^1,2	C,F,H,	--	14583772(-)	`CTCATG/CTGGAT`	1	--	int¹		9		EA NS NA CSA WA	2060

HapMap Linkage Disequilibrium report for PTGER1 (14583278 - 14586174 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PTGER1
2 CNVs: 5090 10543

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PTGER1 for disorders           About GeneDecksing

OMIM gene information: 176802    OMIM disorders: --

20/40 diseases for PTGER1 (see all 40):    About MalaCards

patent ductus arteriosus adenomatous polyposis coli chronic obstructive pulmonary disease barrett's esophagus

esophageal squamous cell carcinoma squamous cell carcinoma glaucoma epithelial ovarian cancer

inflammatory breast cancer pulmonary disease polyposis breast cancer

rheumatoid arthritis colon cancer ovarian cancer cervical adenocarcinoma

skin cancer duodenitis lung adenocarcinoma medulloblastoma

8 Novoseek disease relationships for PTGER1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
intestinal polyps	57	1	11533709 (1)
colon cancer	22.3	1	17906615 (1)
cancer	1.94	2	17906615 (1), 15247185 (1)
glaucoma	0	1	11980863 (1)
stroke	0	2	18597941 (1)
necrosis	0	1	9877447 (1)
breast cancer	0	3	17906615 (3)
tumors	0	7	9877447 (1), 20145019 (1), 18642283 (1), 20100359 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: PTGER1 (12 documents)

Export disorders for PTGER1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PTGER1 gene, integrated from 9 sources (see all 248):
(articles sorted by number of sources associating them with PTGER1)

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world of online information

Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. (PubMed id 8253813)^{1, 2, 3, 9} Funk C.D.... Metters K.M. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prostanoid receptor EP1 expression in breast cancer. (PubMed id 17906615)^{1, 9} Thorat M.A....Badve S.S. (2008)
Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. (PubMed id 15560119)^{7, 9} Norel X....Brink C. (2004)
Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. (PubMed id 16393343)^{1, 9} Durrenberger P.F....Anand P. (2006)
Involvement of EP1 and EP2 receptors in the regulation of the Na,K-ATPase by prostaglandins in MDCK cells. (PubMed id 16516814)^{7, 9} Matlhagela K. and Taub M. (2006)
Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. (PubMed id 11999132)^{7, 9} Sharif N.A. and Davis T.L. (2002)
The EP1 subtype of prostaglandin E2 receptor: role in keratinocyte differentiation and expression in non-melanoma skin cancer. (PubMed id 19625175)^{1, 9} Konger R.L....Lacelle P.T. (2009)
Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. (PubMed id 18715952)^{7, 9} Baryawno N....Johnsen J.I. (2008)
Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. (PubMed id 16331686)^{1, 9} Han C....Wu T. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5731	HGNC: 9593	AceView: PTGER1	Ensembl:ENSG00000160951	euGenes: HUgn5731
ECgene: PTGER1	Kegg: 5731	H-InvDB: PTGER1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PTGER1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PTGER1 gene
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Patent Information for PTGER1 gene:
Search GeneIP for patents involving PTGER1

GeneCards and IP:
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prostaglandin E receptor 1 (subtype EP1), 42kDa

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PTGER1 Gene

prostaglandin E receptor 1 (subtype EP1), 42kDa

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