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Aliases for PTGER1 Gene

Aliases for PTGER1 Gene

  • Prostaglandin E Receptor 1 2 3 5
  • Prostaglandin E Receptor 1 (Subtype EP1), 42kDa 2 3
  • Prostaglandin E Receptor 1 (Subtype EP1), 42kD 2 3
  • PGE2 Receptor EP1 Subtype 3 4
  • PGE Receptor EP1 Subtype 3 4
  • Prostanoid EP1 Receptor 3 4
  • Prostaglandin E Receptor 1, Subtype EP1 3
  • PGE Receptor, EP1 Subtype 3
  • EP1 3

External Ids for PTGER1 Gene

Previous GeneCards Identifiers for PTGER1 Gene

  • GC19M014938
  • GC19M014428
  • GC19M014583
  • GC19M014153

Summaries for PTGER1 Gene

Entrez Gene Summary for PTGER1 Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGER1 Gene

PTGER1 (Prostaglandin E Receptor 1) is a Protein Coding gene. Diseases associated with PTGER1 include tinea barbae and antenatal bartter syndrome. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGER1 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Tocris Summary for PTGER1 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER1 Gene

Genomics for PTGER1 Gene

Regulatory Elements for PTGER1 Gene

Genomic Location for PTGER1 Gene

Chromosome:
19
Start:
14,472,466 bp from pter
End:
14,475,362 bp from pter
Size:
2,897 bases
Orientation:
Minus strand

Genomic View for PTGER1 Gene

Genes around PTGER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER1 Gene

Proteins for PTGER1 Gene

  • Protein details for PTGER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34995-PE2R1_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP1 subtype
    Protein Accession:
    P34995
    Secondary Accessions:
    • Q5U5U4
    • Q86UH3
    • Q86VB5
    • Q8NHB2

    Protein attributes for PTGER1 Gene

    Size:
    402 amino acids
    Molecular mass:
    41801 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05723.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PTGER1 Gene

Proteomics data for PTGER1 Gene at MOPED

Post-translational modifications for PTGER1 Gene

Other Protein References for PTGER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTGER1 Gene

Domains & Families for PTGER1 Gene

Gene Families for PTGER1 Gene

Suggested Antigen Peptide Sequences for PTGER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34995

UniProtKB/Swiss-Prot:

PE2R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER1: view

Function for PTGER1 Gene

Molecular function for PTGER1 Gene

GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP1 (42kDa),G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
genes like me logo Genes that share phenotypes with PTGER1: view

Animal Models for PTGER1 Gene

MGI Knock Outs for PTGER1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTGER1 Gene

Localization for PTGER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER1 Gene COMPARTMENTS Subcellular localization image for PTGER1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PTGER1 Gene

Pathways & Interactions for PTGER1 Gene

genes like me logo Genes that share pathways with PTGER1: view

SIGNOR curated interactions for PTGER1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER1 Gene

None

Drugs & Compounds for PTGER1 Gene

(43) Drugs for PTGER1 Gene - From: IUPHAR, DGIdb, Novoseek, Tocris, ApexBio, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Others, Prostacyclin (PGI2) analog 74
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 129
Dinoprostone Approved Pharma antagonist, Target, agonist Major endogenous prostanoid 74
Alprostadil Approved, Investigational Pharma antagonist, Target, agonist 63
Carboprost Tromethamine Approved Pharma binder, Target, agonist 4

(26) Additional Compounds for PTGER1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-phenyl-<i>omega</i>-trinor-PGE<sub>2</sub>
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
(+-)-Cloprostenol sodium salt
55028-72-3
U 46619
56985-40-1

(5) Tocris Compounds for PTGER1 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(2) ApexBio Compounds for PTGER1 Gene

Compound Action Cas Number
Alprostadil 745-65-3
Bimatoprost 155206-00-1
genes like me logo Genes that share compounds with PTGER1: view

Drug Products

Transcripts for PTGER1 Gene

mRNA/cDNA for PTGER1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGER1 Gene

Prostaglandin E receptor 1 (subtype EP1), 42kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER1 Gene

No ASD Table

Relevant External Links for PTGER1 Gene

GeneLoc Exon Structure for
PTGER1
ECgene alternative splicing isoforms for
PTGER1

Expression for PTGER1 Gene

mRNA expression in normal human tissues for PTGER1 Gene

mRNA differential expression in normal tissues according to GTEx for PTGER1 Gene

This gene is overexpressed in Kidney - Cortex (x11.5) and Spleen (x8.7).

SOURCE GeneReport for Unigene cluster for PTGER1 Gene Hs.159360

mRNA Expression by UniProt/SwissProt for PTGER1 Gene

P34995-PE2R1_HUMAN
Tissue specificity: Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
genes like me logo Genes that share expression patterns with PTGER1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PTGER1 Gene

Orthologs for PTGER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTGER1 35
  • 87.15 (n)
  • 88.81 (a)
EP1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGER1 35
  • 87.53 (n)
  • 86.49 (a)
PTGER1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptger1 35
  • 81.8 (n)
  • 85.29 (a)
Ptger1 16
Ptger1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptger1 35
  • 81.46 (n)
  • 84.29 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGER1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGER1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER1 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptger1a 35
  • 53.46 (n)
  • 51.7 (a)
ptger1a 36
  • 45 (a)
OneToMany
ptger1b 36
  • 45 (a)
OneToMany
Species with no ortholog for PTGER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER1 Gene

ENSEMBL:
Gene Tree for PTGER1 (if available)
TreeFam:
Gene Tree for PTGER1 (if available)

Paralogs for PTGER1 Gene

Paralogs for PTGER1 Gene

(1) SIMAP similar genes for PTGER1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTGER1: view

Variants for PTGER1 Gene

Sequence variations from dbSNP and Humsavar for PTGER1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1057362 - 14,474,110(-) CGGCC(A/G)CCACC reference, missense
rs28364042 - 14,473,653(-) CAACA(C/T)GCTCA reference, missense
rs7249305 - 14,473,554(+) GTCCG(C/T)GCGCC reference, missense
rs1057368 -- 14,472,526(-) AGCCC(A/C)CCCTG utr-variant-3-prime
rs3745459 -- 14,473,505(-) TCGGC(C/T)TCCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PTGER1 Gene

Variant ID Type Subtype PubMed ID
nsv833764 CNV Loss 17160897
nsv911121 CNV Loss 21882294
nsv911122 CNV Loss 21882294
nsv470127 CNV Loss 18288195
nsv911126 CNV Gain 21882294
nsv911127 CNV Loss 21882294
nsv817814 CNV Loss 17921354
nsv527867 CNV Loss 19592680

Variation tolerance for PTGER1 Gene

Gene Damage Index Score: 5.25; 70.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGER1 Gene

HapMap Linkage Disequilibrium report
PTGER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER1 Gene

Disorders for PTGER1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTGER1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tinea barbae
  • dermatophytosis of beard
antenatal bartter syndrome
  • bartter syndrome, furosemide type
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTGER1

Genetic Association Database (GAD)
PTGER1
Human Genome Epidemiology (HuGE) Navigator
PTGER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGER1
genes like me logo Genes that share disorders with PTGER1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER1 Gene

Publications for PTGER1 Gene

  1. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. (PMID: 8253813) Funk C.D. … Metters K.M. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. (PMID: 11999132) Sharif N.A. … Davis T.L. (J. Pharm. Pharmacol. 2002) 23 25 26
  3. Labour is associated with decreased expression of the PGF2alpha receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua. (PMID: 20519365) Hay A. … Slater D.M. (Mol. Hum. Reprod. 2010) 25 26
  4. The EP1 subtype of prostaglandin E2 receptor: role in keratinocyte differentiation and expression in non-melanoma skin cancer. (PMID: 19625175) Konger R.L. … Lacelle P.T. (Prostaglandins Leukot. Essent. Fatty Acids 2009) 3 23
  5. The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. (PMID: 19690271) Beloeil H. … Mazoit J.X. (Anesth. Analg. 2009) 25 26

Products for PTGER1 Gene

Sources for PTGER1 Gene

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