Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTGER1 Gene

Aliases for PTGER1 Gene

  • Prostaglandin E Receptor 1 2 3 5
  • Prostaglandin E Receptor 1 (Subtype EP1), 42kDa 2 3
  • Prostaglandin E Receptor 1 (Subtype EP1), 42kD 2 3
  • PGE2 Receptor EP1 Subtype 3 4
  • Prostanoid EP1 Receptor 3 4
  • Prostaglandin E Receptor 1, Subtype EP1 3
  • Prostaglandin E2 Receptor EP1 Subtype 3
  • PGE Receptor, EP1 Subtype 3
  • PGE Receptor EP1 Subtype 4
  • EP1 3

External Ids for PTGER1 Gene

Previous GeneCards Identifiers for PTGER1 Gene

  • GC19M014938
  • GC19M014428
  • GC19M014583
  • GC19M014153

Summaries for PTGER1 Gene

Entrez Gene Summary for PTGER1 Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGER1 Gene

PTGER1 (Prostaglandin E Receptor 1) is a Protein Coding gene. Diseases associated with PTGER1 include Tinea Barbae and Antenatal Bartter Syndrome. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGFR.

UniProtKB/Swiss-Prot for PTGER1 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Tocris Summary for PTGER1 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER1 Gene

Genomics for PTGER1 Gene

Regulatory Elements for PTGER1 Gene

Enhancers for PTGER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F014479 0.7 Ensembl ENCODE 6.4 -4.9 -4892 1.6 HDGF CBX3 PKNOX1 KLF17 ZNF2 RAD21 GLIS2 CBX5 ZNF143 ZNF391 PTGER1 PKN1 SNRPGP15
GH19F014471 1.1 Ensembl ENCODE 6.3 +0.1 84 7.8 HDGF ATF1 PKNOX1 ZNF133 ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 ZNF207 CCDC130 AKAP8 MRI1 ZNF333 RFX1 NANOS3 DCAF15 PKN1 PTGER1 GIPC1
GH19F014465 0.5 FANTOM5 0.4 +9.4 9410 0.4 PKN1 ENSG00000267474 PTGER1
GH19F014486 0.2 ENCODE 0.4 -11.2 -11182 0.2 BCOR CTCF ATF1 CBX3 TBL1XR1 MAX RAD21 POLR2A NCOR1 SCRT2 SNRPGP15 PTGER1
GH19F014459 1 FANTOM5 ENCODE 0.3 +15.6 15594 1.0 ZNF121 ZMYM3 KDM1A OR7C2 DDX39A IL27RA PKN1 ZNF333 ENSG00000267474 PTGER1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PTGER1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PTGER1 Gene

Chromosome:
19
Start:
14,472,466 bp from pter
End:
14,475,362 bp from pter
Size:
2,897 bases
Orientation:
Minus strand

Genomic View for PTGER1 Gene

Genes around PTGER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER1 Gene

Proteins for PTGER1 Gene

  • Protein details for PTGER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34995-PE2R1_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP1 subtype
    Protein Accession:
    P34995
    Secondary Accessions:
    • Q5U5U4
    • Q86UH3
    • Q86VB5
    • Q8NHB2

    Protein attributes for PTGER1 Gene

    Size:
    402 amino acids
    Molecular mass:
    41801 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05723.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PTGER1 Gene

Post-translational modifications for PTGER1 Gene

Other Protein References for PTGER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGER1 Gene

Domains & Families for PTGER1 Gene

Gene Families for PTGER1 Gene

Suggested Antigen Peptide Sequences for PTGER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34995

UniProtKB/Swiss-Prot:

PE2R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER1: view

Function for PTGER1 Gene

Molecular function for PTGER1 Gene

GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP1 (42kDa),G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Gene Ontology (GO) - Molecular Function for PTGER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004955 prostaglandin receptor activity IEA --
GO:0004957 prostaglandin E receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with PTGER1: view
genes like me logo Genes that share phenotypes with PTGER1: view

Animal Models for PTGER1 Gene

MGI Knock Outs for PTGER1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTGER1 Gene

Localization for PTGER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGER1 Gene COMPARTMENTS Subcellular localization image for PTGER1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTGER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8253813
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTGER1: view

Pathways & Interactions for PTGER1 Gene

genes like me logo Genes that share pathways with PTGER1: view

SIGNOR curated interactions for PTGER1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8253813
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA --
genes like me logo Genes that share ontologies with PTGER1: view

Drugs & Compounds for PTGER1 Gene

(48) Drugs for PTGER1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Others, Prostacyclin (PGI2) analog 77
Alprostadil Approved, Investigational Pharma antagonist, Target, agonist Prostaglandin. Vasodilator and antiplatelet agent in vivo 69
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 132
Carboprost Tromethamine Approved Pharma binder, Target, agonist 6
Bupivacaine Approved, Investigational Pharma Pore Blocker, Target, other/unknown 1131

(22) Additional Compounds for PTGER1 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-phenyl-<i>omega</i>-trinor-PGE<sub>2</sub>
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist

(5) Tocris Compounds for PTGER1 Gene

Compound Action Cas Number
Alprostadil Prostaglandin. Vasodilator and antiplatelet agent in vivo 745-65-3
Iloprost Prostacyclin (PGI2) analog 78919-13-8
L-798,106 Potent and highly selective EP3 antagonist 244101-02-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(4) ApexBio Compounds for PTGER1 Gene

Compound Action Cas Number
AH 6809 EP and DP receptor antagonist 33458-93-4
Alprostadil 745-65-3
Bimatoprost 155206-00-1
SC 19220 19395-87-0
genes like me logo Genes that share compounds with PTGER1: view

Drug Products

Transcripts for PTGER1 Gene

mRNA/cDNA for PTGER1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGER1 Gene

Prostaglandin E receptor 1 (subtype EP1), 42kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER1 Gene

No ASD Table

Relevant External Links for PTGER1 Gene

GeneLoc Exon Structure for
PTGER1
ECgene alternative splicing isoforms for
PTGER1

Expression for PTGER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGER1 Gene

mRNA differential expression in normal tissues according to GTEx for PTGER1 Gene

This gene is overexpressed in Kidney - Cortex (x11.5) and Spleen (x8.7).

NURSA nuclear receptor signaling pathways regulating expression of PTGER1 Gene:

PTGER1

SOURCE GeneReport for Unigene cluster for PTGER1 Gene:

Hs.159360

mRNA Expression by UniProt/SwissProt for PTGER1 Gene:

P34995-PE2R1_HUMAN
Tissue specificity: Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
genes like me logo Genes that share expression patterns with PTGER1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PTGER1 Gene

Orthologs for PTGER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EP1 35
  • 88 (a)
OneToOne
PTGER1 34
  • 87.15 (n)
dog
(Canis familiaris)
Mammalia PTGER1 34 35
  • 87.53 (n)
mouse
(Mus musculus)
Mammalia Ptger1 34 16 35
  • 81.8 (n)
rat
(Rattus norvegicus)
Mammalia Ptger1 34
  • 81.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTGER1 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTGER1 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER1 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptger1a 34 35
  • 53.46 (n)
ptger1b 35
  • 45 (a)
OneToMany
Species where no ortholog for PTGER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER1 Gene

ENSEMBL:
Gene Tree for PTGER1 (if available)
TreeFam:
Gene Tree for PTGER1 (if available)

Paralogs for PTGER1 Gene

Paralogs for PTGER1 Gene

(1) SIMAP similar genes for PTGER1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTGER1: view

Variants for PTGER1 Gene

Sequence variations from dbSNP and Humsavar for PTGER1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10409136 -- 14,476,563(+) CTAGA(C/G)ACCCC upstream-variant-2KB
rs10410484 -- 14,476,437(+) CAGCA(A/C)ACTCC upstream-variant-2KB
rs10410510 -- 14,476,477(+) CCCGC(C/T)GCTGG upstream-variant-2KB
rs10416814 -- 14,476,390(+) TCTGT(A/T)TGACT upstream-variant-2KB
rs10416825 -- 14,476,408(+) ACCCC(C/T)CAACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTGER1 Gene

Variant ID Type Subtype PubMed ID
nsv470127 CNV loss 18288195
nsv527867 CNV loss 19592680
nsv817814 CNV loss 17921354
nsv833764 CNV loss 17160897

Variation tolerance for PTGER1 Gene

Gene Damage Index Score: 5.25; 70.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER1 Gene

Disorders for PTGER1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTGER1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tinea barbae
  • dermatophytosis of beard
antenatal bartter syndrome
  • hyperprostaglandin e syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PTGER1

Genetic Association Database (GAD)
PTGER1
Human Genome Epidemiology (HuGE) Navigator
PTGER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGER1
genes like me logo Genes that share disorders with PTGER1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER1 Gene

Publications for PTGER1 Gene

  1. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. (PMID: 8253813) Funk C.D. … Metters K.M. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64
  5. Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics. (PMID: 20587336) Park B.L. … Shin H.D. (BMB Rep 2010) 3 46 64

Products for PTGER1 Gene

Sources for PTGER1 Gene

Content
Loading form....