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Aliases for PTGDS Gene

Aliases for PTGDS Gene

  • Prostaglandin D2 Synthase 2 3 5
  • Lipocalin-Type Prostaglandin D Synthase 2 3
  • Prostaglandin D2 Synthase 21kDa (Brain) 2 3
  • Glutathione-Independent PGD Synthase 3 4
  • Beta-Trace Protein 3 4
  • PGD2 Synthase 3 4
  • Cerebrin-28 3 4
  • EC 5.3.99.2 4 61
  • PGDS2 3 4
  • PGDS 3 4
  • PDS 3 4
  • Testis Tissue Sperm-Binding Protein Li 63n 3
  • Lipocalin-Type Prostaglandin-D Synthase 4
  • Prostaglandin D2 Synthase (21kD, Brain) 2
  • Glutathione-Independent PGD Synthetase 3
  • Prostaglandin-H2 D-Isomerase 3
  • Prostaglandin-D2 Synthase 4
  • Prostaglandin D Synthase 3
  • L-PGDS 3
  • LPGDS 3
  • PGD2 3

External Ids for PTGDS Gene

Previous GeneCards Identifiers for PTGDS Gene

  • GC09M131178
  • GC09P131561
  • GC09P133310
  • GC09P135226
  • GC09P137145
  • GC09P138989
  • GC09P139871
  • GC09P109331

Summaries for PTGDS Gene

Entrez Gene Summary for PTGDS Gene

  • The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGDS Gene

PTGDS (Prostaglandin D2 Synthase) is a Protein Coding gene. Diseases associated with PTGDS include Egg Allergy and Cerebrospinal Fluid Leak. Among its related pathways are Ibuprofen Pathway, Pharmacodynamics and Circadian rythm related genes. GO annotations related to this gene include transporter activity and retinoid binding. An important paralog of this gene is ENSG00000284341.

UniProtKB/Swiss-Prot for PTGDS Gene

  • Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Tocris Summary for PTGDS Gene

Gene Wiki entry for PTGDS Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGDS Gene

Genomics for PTGDS Gene

Regulatory Elements for PTGDS Gene

Enhancers for PTGDS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136963 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.4 -10.6 -10600 1.1 HDAC1 PKNOX1 KLF17 GLIS2 EGR1 RCOR1 KLF7 CREM EGR2 ZNF263 PTGDS PRR31 LCN12
GH09G136965 1 Ensembl ENCODE 15.4 -9.1 -9097 1.2 PKNOX1 ESRRA KLF1 ATF1 ZBTB21 ZNF121 ZBTB48 EGR1 CREM RFX1 LCN12 PTGDS PRR31
GH09G136959 0.4 ENCODE 14.7 -14.7 -14720 1.2 EGR2 LCN12 PTGDS PRR31
GH09G136524 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -444.7 -444656 11.2 HDGF PKNOX1 FEZF1 GLI4 ZNF121 GLIS2 FOS ZNF263 SP5 ZNF610 NALT1 NOTCH1 DNLZ SEC16A C9orf172 PTGDS LCNL1 NACC2 CARD9 ENSG00000227512
GH09G137233 1.8 FANTOM5 ENCODE dbSUPER 1.4 +263.2 263214 9.9 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NDOR1 DPH7 TMEM203 NELFB LCN15 ABCA2 TOR4A UAP1L1 RNF224 CYSRT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTGDS on UCSC Golden Path with GeneCards custom track

Promoters for PTGDS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243112 696 401 HDAC1 KLF1 RB1 TEAD4 ZFHX2 EGR1 POLR2A TRIM24 KLF8 CHD2

Genomic Location for PTGDS Gene

Chromosome:
9
Start:
136,975,092 bp from pter
End:
136,981,742 bp from pter
Size:
6,651 bases
Orientation:
Plus strand

Genomic View for PTGDS Gene

Genes around PTGDS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGDS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGDS Gene

Proteins for PTGDS Gene

  • Protein details for PTGDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41222-PTGDS_HUMAN
    Recommended name:
    Prostaglandin-H2 D-isomerase
    Protein Accession:
    P41222
    Secondary Accessions:
    • B2R727
    • Q5SQ10
    • Q7M4P3
    • Q9UC22
    • Q9UCC9
    • Q9UCD9

    Protein attributes for PTGDS Gene

    Size:
    190 amino acids
    Molecular mass:
    21029 Da
    Quaternary structure:
    • Monomer.
    • Monomer.
    Miscellaneous:
    • It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma. Expression levels in amniotic fluid are altered in abnormal pregnancies. Levels are lower in pregnancies with trisomic fetuses and fetuses with renal abnormalities.

    Three dimensional structures from OCA and Proteopedia for PTGDS Gene

neXtProt entry for PTGDS Gene

Selected DME Specific Peptides for PTGDS Gene

P41222:
  • SPHWGSTYSVSVVETDYD
  • IVFLPQTDKC
  • GGLNLTSTFLRKNQCET
  • DKFLGRWFSAGLASNSSWL
  • SLGSYSY
  • HTLWMGL
  • MATLYSR
  • QPNFQQDKFLGRW

Post-translational modifications for PTGDS Gene

  • N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.
  • Glycosylation at isoforms=29, isoforms=51, and isoforms=78
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGDS Gene

Antibody Products

  • R&D Systems Antibodies for PTGDS (PGD2 Synthase/PTGDS)
  • Cloud-Clone Corp. Antibodies for PTGDS

Domains & Families for PTGDS Gene

Gene Families for PTGDS Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for PTGDS Gene

Graphical View of Domain Structure for InterPro Entry

P41222

UniProtKB/Swiss-Prot:

PTGDS_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Lipocalin family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with PTGDS: view

Function for PTGDS Gene

Molecular function for PTGDS Gene

GENATLAS Biochemistry:
prostaglandin D2 synthase,glutathione independent,21kDa,brain-specific,membrane associated lipocalcin family
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
UniProtKB/Swiss-Prot Induction:
By IL1B/interleukin-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone (DHT), progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway.

Enzyme Numbers (IUBMB) for PTGDS Gene

Gene Ontology (GO) - Molecular Function for PTGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004667 prostaglandin-D synthase activity TAS --
GO:0005215 transporter activity IEA,ISS --
GO:0005501 retinoid binding ISS --
GO:0005504 fatty acid binding IDA 20667974
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PTGDS: view
genes like me logo Genes that share phenotypes with PTGDS: view

Animal Models for PTGDS Gene

MGI Knock Outs for PTGDS:

Animal Model Products

miRNA for PTGDS Gene

miRTarBase miRNAs that target PTGDS

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGDS Gene

Localization for PTGDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGDS Gene

Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGDS gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 4
golgi apparatus 4
peroxisome 2
plasma membrane 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 7692978
GO:0005615 extracellular space IDA 19878301
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PTGDS: view

Pathways & Interactions for PTGDS Gene

genes like me logo Genes that share pathways with PTGDS: view

Gene Ontology (GO) - Biological Process for PTGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006693 prostaglandin metabolic process IEA --
genes like me logo Genes that share ontologies with PTGDS: view

No data available for SIGNOR curated interactions for PTGDS Gene

Drugs & Compounds for PTGDS Gene

(13) Drugs for PTGDS Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AT 56 Pharma L-PGDS inhibitor 0
N1,N12-Diethylspermine tetrahydrochloride Pharma 0
Borrelidin Pharma Antiangiogenic; inhibits threonyl-tRNA synthetase 0
HQL 79 Pharma Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor 0
Triacsin C Pharma Inhibitor of acyl-CoA synthetase 0

(17) Additional Compounds for PTGDS Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin D2
  • (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoate
  • (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
  • (5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
  • (5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
  • (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate
41598-07-6
Prostaglandin H2
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate
  • (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate
  • (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
  • (5Z,13E)-(15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dienoate
42935-17-1
PD 404182
72596-74-8

(5) Tocris Compounds for PTGDS Gene

Compound Action Cas Number
AT 56 L-PGDS inhibitor 162640-98-4
Borrelidin Antiangiogenic; inhibits threonyl-tRNA synthetase 7184-60-3
HQL 79 Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor 162641-16-9
PD 404182 High affinity inhibitor of KDO 8-P synthase; also DDAH1 inhibitor 72596-74-8
Triacsin C Inhibitor of acyl-CoA synthetase 76896-80-5

(2) ApexBio Compounds for PTGDS Gene

Compound Action Cas Number
AT 56 L-PGDS inhibitor 162640-98-4
N1,N12-Diethylspermine tetrahydrochloride 113812-15-0
genes like me logo Genes that share compounds with PTGDS: view

Drug Products

Transcripts for PTGDS Gene

Unigene Clusters for PTGDS Gene

Prostaglandin D2 synthase 21kDa (brain):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGDS Gene

No ASD Table

Relevant External Links for PTGDS Gene

GeneLoc Exon Structure for
PTGDS
ECgene alternative splicing isoforms for
PTGDS

Expression for PTGDS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGDS Gene

mRNA differential expression in normal tissues according to GTEx for PTGDS Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.0) and Heart - Left Ventricle (x5.0).

Protein differential expression in normal tissues from HIPED for PTGDS Gene

This gene is overexpressed in Cerebrospinal fluid (39.8), Vitreous humor (17.5), and Urine (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGDS Gene



NURSA nuclear receptor signaling pathways regulating expression of PTGDS Gene:

PTGDS

SOURCE GeneReport for Unigene cluster for PTGDS Gene:

Hs.446429

mRNA Expression by UniProt/SwissProt for PTGDS Gene:

P41222-PTGDS_HUMAN
Tissue specificity: Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.

Evidence on tissue expression from TISSUES for PTGDS Gene

  • Nervous system(5)
  • Eye(4.8)
  • Liver(4.3)
  • Bone marrow(4.1)
  • Heart(3.6)
  • Muscle(3.2)
  • Kidney(3)
  • Lymph node(2.6)
  • Gall bladder(2.4)
  • Intestine(2.3)
  • Skin(2.3)
  • Spleen(2.3)
  • Lung(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with PTGDS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGDS Gene

Orthologs for PTGDS Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGDS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGDS 34 35
  • 97.97 (n)
dog
(Canis familiaris)
Mammalia PTGDS 34 35
  • 82.75 (n)
mouse
(Mus musculus)
Mammalia Ptgds 34 16 35
  • 80.78 (n)
cow
(Bos Taurus)
Mammalia PTGDS 34 35
  • 78.77 (n)
rat
(Rattus norvegicus)
Mammalia Ptgds 34
  • 77.25 (n)
oppossum
(Monodelphis domestica)
Mammalia PTGDS 35
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGDS 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGDS 34 35
  • 60.38 (n)
lizard
(Anolis carolinensis)
Reptilia PTGDS 35
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ptgdsb 35
  • 29 (a)
OneToMany
PTGDS (2 of 3) 35
  • 24 (a)
OneToMany
PTGDS (3 of 3) 35
  • 22 (a)
OneToMany
Species where no ortholog for PTGDS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGDS Gene

ENSEMBL:
Gene Tree for PTGDS (if available)
TreeFam:
Gene Tree for PTGDS (if available)

Paralogs for PTGDS Gene

Paralogs for PTGDS Gene

(2) SIMAP similar genes for PTGDS Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PTGDS: view

Variants for PTGDS Gene

Sequence variations from dbSNP and Humsavar for PTGDS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000092726 -- 136,980,997(+) GCAGT(C/T)CAGGG intron-variant, upstream-variant-2KB
rs1000652730 -- 136,979,309(+) GTGGG(C/G)CCTCC intron-variant
rs1000941853 -- 136,979,672(+) GGAAA(A/C)CTCTT intron-variant
rs1001446297 -- 136,982,051(+) AGGTG(C/T)CCTGC downstream-variant-500B, upstream-variant-2KB
rs1002876644 -- 136,979,357(+) CGGGA(C/G)GACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGDS Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
dgv13008n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv615991 CNV loss 21841781
nsv615992 CNV loss 21841781
nsv615993 CNV gain 21841781
nsv615994 CNV gain 21841781
nsv615995 CNV loss 21841781
nsv615997 CNV loss 21841781
nsv616002 CNV loss 21841781
nsv818738 CNV gain 17921354
nsv951206 CNV deletion 24416366

Variation tolerance for PTGDS Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGDS Gene

Human Gene Mutation Database (HGMD)
PTGDS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGDS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGDS Gene

Disorders for PTGDS Gene

MalaCards: The human disease database

(15) MalaCards diseases for PTGDS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
egg allergy
  • allergy to eggs
cerebrospinal fluid leak
  • csf leak
normal pressure hydrocephalus
  • low pressure hydrocephalus
complete androgen insensitivity syndrome
  • testicular feminization
macular holes
  • macular hole
- elite association - COSMIC cancer census association via MalaCards
Search PTGDS in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTGDS

Genetic Association Database (GAD)
PTGDS
Human Genome Epidemiology (HuGE) Navigator
PTGDS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGDS
genes like me logo Genes that share disorders with PTGDS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGDS Gene

Publications for PTGDS Gene

  1. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PMID: 19276290) Abraham J.E. … Pharoah P.D. (Clin. Cancer Res. 2009) 3 22 46 64
  2. Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia. (PMID: 17230501) Ruano D. … Palha J.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 22 46 64
  3. Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients. (PMID: 15325247) Miwa Y. … Kawano Y. (Biochem. Biophys. Res. Commun. 2004) 3 22 46 64
  4. Lipocalin-type prostaglandin D synthase in essential hypertension. (PMID: 11882588) Hirawa N. … Umemura S. (Hypertension 2002) 3 4 22 64
  5. Charge microheterogeneity of the beta-trace proteins (lipocalin-type prostaglandin D synthase) in the cerebrospinal fluid of patients with neurological disorders analyzed by capillary isoelectrofocusing. (PMID: 11669522) Hiraoka A. … Baba K. (Electrophoresis 2001) 3 4 22 64

Products for PTGDS Gene

Sources for PTGDS Gene

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