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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGDS Gene

protein-coding   GIFtS: 70
GCID: GC09P139871

Prostaglandin D2 Synthase 21kDa (Brain)

(Previous names: prostaglandin D2 synthase (21kD, brain))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prostaglandin D2 Synthase 21kDa (Brain)1 2     EC 5.3.99.23 8
Lipocalin-Type Prostaglandin D Synthase1 2     Prostaglandin D2 Synthase (21kD, Brain)1
Beta-Trace Protein2 3     L-PGDS2
Glutathione-Independent PGD Synthase2 3     LPGDS2
Lipocalin-Type Prostaglandin-D Synthase2 3     PGD22
Prostaglandin-D2 Synthase2 3     cerebrin-282
PDS2 3     Glutathione-Independent PGD Synthetase2
PGDS2 3     Prostaglandin D Synthase2
PGDS22 3     Prostaglandin-H2 D-Isomerase2
PGD2 Synthase2 3     Cerebrin-283

External Ids:    HGNC: 95921   Entrez Gene: 57302   Ensembl: ENSG000001073177   OMIM: 1768035   UniProtKB: P412223   

Export aliases for PTGDS gene to outside databases

Previous GC identifers: GC09M131178 GC09P131561 GC09P133310 GC09P135226 GC09P137145 GC09P138989 GC09P109331


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGDS Gene:
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the
conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a
trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and
is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with
transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of
non-rapid eye movement sleep. (provided by RefSeq, Jul 2008)

GeneCards Summary for PTGDS Gene: 
PTGDS (prostaglandin D2 synthase 21kDa (brain)) is a protein-coding gene. Diseases associated with PTGDS include meninges hemangiopericytoma, and normal pressure hydrocephalus, and among its related super-pathways are Prostaglandin 2 biosynthesis and metabolism FM and Metabolic pathways. GO annotations related to this gene include retinoid binding and transporter activity. An important paralog of this gene is LCNL1.

UniProtKB/Swiss-Prot: PTGDS_HUMAN, P41222
Function: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle
contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions,
such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.
Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and
thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and
thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina,
blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and
maintenance of the central nervous system and male reproductive system

Gene Wiki entry for PTGDS (Prostaglandin D2 synthase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGDS gene promoter:
         c-Fos   CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTGDS promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGDS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.2-q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.2-q34.3

PTGDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGDS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139871:  view genomic region     (about GC identifiers)

Start:
139,871,956 bp from pter      End:
139,879,887 bp from pter
Size:
7,932 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTGDS_HUMAN, P41222 (See protein sequence)
Recommended Name: Prostaglandin-H2 D-isomerase precursor  
Size: 190 amino acids; 21029 Da
Subunit: Monomer
Subcellular location: Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear
region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the
nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid
trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial
cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment
epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted
Developmental stage: Expression in the amniotic fluid increases dramatically during weeks 12 to 25 of pregnancy.
Levels decrease slowly after 25 weeks
Miscellaneous: It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal
damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated
with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked
oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma
but not in other brain tumors and may be considered a specific cell marker for meningioma. Expression levels in
amniotic fluid are altered in abnormal pregnancies. Levels are lower in pregnancies with trisomic fetuses and
fetuses with renal abnormalities
6 PDB 3D structures from and Proteopedia for PTGDS:
2WWP (3D)        3O19 (3D)        3O22 (3D)        3O2Y (3D)        4IMN (3D)        4IMO (3D)    
Secondary accessions: B2R727 Q5SQ10 Q7M4P3 Q9UC22 Q9UCC9 Q9UCD9

Explore the universe of human proteins at neXtProt for PTGDS: NX_P41222

Explore proteomics data for PTGDS at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of
    the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan
    at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing
    alpha2-3- and/or alpha2-6-linked NeuNAc are present
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41222

  • 4/8 DME Specific Peptides for PTGDS (P41222) (see all 8)
     HTLWMGL  SLGSYSY  MATLYSR  IVFLPQTDKC 

    PTGDS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGDS Protein Expression
    REFSEQ proteins: NP_000945.3  
    ENSEMBL proteins: 
     ENSP00000392633   ENSP00000360687   ENSP00000360685   ENSP00000435033   ENSP00000397468  
     ENSP00000392692   ENSP00000224167  
    Reactome Protein details: P41222
    Human Recombinant Protein Products for PTGDS: 
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    Novus Biologicals PTGDS Proteins
    Novus Biologicals PTGDS Lysates
    Sino Biological Recombinant Protein for PTGDS
    Sino Biological Cell Lysate for PTGDS 
    ProSpec Recombinant Protein for PTGDS
    Cloud-Clone Corp. Proteins for PTGDS 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA7692978
    GO:0005615extracellular space IDA19878301
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005791rough endoplasmic reticulum IDA9065498
    GO:0005794Golgi apparatus ISS--

    PTGDS for ontologies           About GeneDecksing



    PTGDS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PTGDS
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    Abcam antibodies for PTGDS
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    Assay Products for PTGDS: 
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    Cloud-Clone Corp. ELISAs for PTGDS 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LCN: Lipocalins

    IUPHAR Guide to PHARMACOLOGY protein family classification: L-PGDS 
    Prostaglandin synthases

    5/6 InterPro protein domains (see all 6):
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR002345 Lipocalin
     IPR022272 Lipocalin_CS
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P41222

    ProtoNet protein and cluster: P41222

    2 Blocks protein domains:
    IPB002345 Lipocalin signature
    IPB002972 Prostaglandin D synthase signature


    UniProtKB/Swiss-Prot: PTGDS_HUMAN, P41222
    Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
    Similarity: Belongs to the calycin superfamily. Lipocalin family


    PTGDS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTGDS_HUMAN, P41222
    Function: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle
    contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions,
    such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.
    Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and
    thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and
    thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina,
    blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and
    maintenance of the central nervous system and male reproductive system
    Catalytic activity: (5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
    Induction: By IL1B/interleukin-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone
    (DHT), progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway

         Genatlas biochemistry entry for PTGDS:
    prostaglandin D2 synthase,glutathione independent,21kDa,brain-specific,membrane associated lipocalcin family

         Enzyme Number (IUBMB): EC 5.3.99.21 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004667prostaglandin-D synthase activity ISS--
    GO:0005215transporter activity ISS--
    GO:0005501retinoid binding ISS--
    GO:0005504fatty acid binding IDA--
    GO:0036094small molecule binding ----
         
    PTGDS for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ptgds):
     behavior/neurological  immune system  integument  mortality/aging  no phenotypic analysis 
     tumorigenesis 

    PTGDS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTGDS: Ptgdstm1Mfg Ptgdstm1Ohy

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGDS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGDS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGDS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGDS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGDS
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGDS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTGDS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.42
    C20 prostanoid biosynthesis0.40
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Arachidonic acid metabolism0.44
    4Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation
    5Eicosanoid Synthesis
    Eicosanoid Synthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PTGDS
        Prostaglandin 2 biosynthesis and metabolism FM


    1 GeneGo (Thomson Reuters) Pathway for PTGDS
        Prostaglandin 2 biosynthesis and metabolism FM

    3 BioSystems Pathways for PTGDS
        Eicosanoid Synthesis
    Prostaglandin Synthesis and Regulation
    C20 prostanoid biosynthesis


    4        Reactome Pathways for PTGDS
        Metabolism
    Arachidonic acid metabolism
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for PTGDS):
        Arachidonic acid metabolism
    Metabolic pathways


    PTGDS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/23 Interacting proteins for PTGDS (P412222, 3 ENSP000003606874) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2862313 MINT-2862294 I2D: score=3 STRING: ENSP00000244769
    CAPN1P073843, ENSP000002792474I2D: score=3 STRING: ENSP00000279247
    HK2P527893, ENSP000002905734I2D: score=3 STRING: ENSP00000290573
    PTGER1P349953, ENSP000002925134I2D: score=2 STRING: ENSP00000292513
    PTGER2P431163, ENSP000002454574I2D: score=1 STRING: ENSP00000245457
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process ISS--
    GO:0006629lipid metabolic process ----
    GO:0006810transport ISS--
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019371cyclooxygenase pathway TAS--

    PTGDS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGDS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PTGDS available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RisedronateFarnesyl diphosphate (FPP) synthase inhibitor[115436-72-1]
    BorrelidinAntiangiogenic; inhibits threonyl-tRNA synthetase[7184-60-3]
    AT 56L-PGDS inhibitor[162640-98-4]
    TrifluorothymidineThymidylate synthase inhibitor; induces DNA fragmentation[70-00-8]
    HQL 79Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor[162641-16-9]

    1 HMDB Compound for PTGDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--

    10/22 Novoseek inferred chemical compound relationships for PTGDS gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pgd2 94 144 16154157 (8), 16986732 (5), 1588043 (5), 20080921 (5) (see all 60)
    prostaglandin 78.2 26 12020781 (2), 14695453 (1), 16986732 (1), 16842938 (1) (see all 15)
    prostaglandin-h2 78.1 8 8599604 (1), 8761996 (1), 11339279 (1), 20386697 (1) (see all 7)
    pgh2 67.3 5 16986732 (1), 12432930 (1), 20122226 (1), 9844724 (1)
    bw245c 67.2 1 12494276 (1)
    15-deoxy-delta-12,14-prostaglandin j2 62.2 1 12623786 (1)
    ltc4 51.3 3 9821474 (1), 19364335 (1), 1588043 (1)
    retinoid 30.9 3 9188476 (1), 10650953 (1)
    retinoic acid 28 5 12842099 (1), 10650953 (1), 18812854 (1)
    ctp 27.4 4 10819784 (2), 16431015 (1)

    Search CenterWatch for drugs/clinical trials and news about PTGDS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PTGDS gene: 
    NM_000954.5  

    Unigene Cluster for PTGDS:

    Prostaglandin D2 synthase 21kDa (brain)
    Hs.446429  [show with all ESTs]
    Unigene Representative Sequence: BM805807
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457950 ENST00000371625 ENST00000371623 ENST00000471521 ENST00000446677
    ENST00000460340 ENST00000492068 ENST00000462514 ENST00000444903 ENST00000467871
    ENST00000224167(uc004ckd.3 uc004cke.3)

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    Additional mRNA sequence: 

    AK075333.1 AK312817.1 AY026356.1 BC005939.1 BT019921.1 BT019922.1 M61900.2 

    24/25 DOTS entries (see all 25):

    DT.419709  DT.75169245  DT.100031548  DT.438690  DT.91798653  DT.91798752  DT.95278750  DT.121164037 
    DT.95278758  DT.95278767  DT.100031549  DT.97791735  DT.92058707  DT.92005211  DT.92017473  DT.95139548 
    DT.95278763  DT.100817884  DT.121164021  DT.121164049  DT.95278695  DT.95278765  DT.95278769  DT.97855711 

    24/821 AceView cDNA sequences (see all 821):

    AI459994 BM686108 C05072 AA318579 BM691524 BM704712 AA383276 AJ710229 
    AL044730 BM686168 CA389079 BQ876483 AA325421 CR594734 CR612267 BM690894 
    BM694186 BM688894 BQ721571 BM707788 AA318109 BM696486 AL044876 N50461 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGDS expression in normal human tissues (normalized intensities)      PTGDS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGGAACAAT
    PTGDS Expression
    About this image


    PTGDS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Human Brain Vascular Pericyte (HBVP)   
             Trigeminal Ganglion   
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             AII Amacrine Cells Inner Nuclear Layer
             Retina
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             XY Germ Cells Testis Cord
             Testis Interstitium
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Node
             heart/ventricle   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem progenitor RP1-MV2-8

    See PTGDS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGDS

    SOURCE GeneReport for Unigene cluster: Hs.446429

    UniProtKB/Swiss-Prot: PTGDS_HUMAN, P41222
    Tissue specificity: Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and
    secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is
    expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye
    and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine,
    ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian
    tubes, kidney, leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including PTGDS: 
              Circadian Rhythms in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PTGDS gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgds1 , 5 prostaglandin D2 synthase (brain)1, 5 80.78(n)1
    72.49(a)1
      2 (17.28 cM)5
    192151  NM_008963.21  NP_032989.21 
     254667095 
    chicken
    (Gallus gallus)
    Aves PTGDS1 prostaglandin D2 synthase 21kDa (brain) 60.38(n)
    46.86(a)
      374110  NM_204259.1  NP_989590.1 
    lizard
    (Anolis carolinensis)
    Reptilia PTGDS6
    Uncharacterized protein
    41(a)
    1 ↔ 1
    2(111665236-111669244)
    zebrafish
    (Danio rerio)
    Actinopterygii lcn151 lipocalin 15 43.52(n)
    31.21(a)
      751703  NM_001045415.1  NP_001038880.1 


    ENSEMBL Gene Tree for PTGDS (if available)
    TreeFam Gene Tree for PTGDS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGDS gene
    LCNL12  LCN152  
    2 SIMAP similar genes for PTGDS using alignment to 6 protein entries:     PTGDS_HUMAN (see all proteins):
    AMBP    NGAL

    PTGDS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/168 SNPs in PTGDS are shown (see all 168)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470812241,2
    --139869964(+) TGGGAC/TCTGCT 1 -- us2k10--------
    rs38145001,2
    C,F,A,H--139870090(+) GGACCT/CGGCCC 1 -- us2k119Minor allele frequency- C:0.26NS EA NA WA CSA 887
    rs38145011,2
    C,F,A,H--139870113(+) GAGTCT/CCTCCC 1 -- us2k117Minor allele frequency- C:0.30NS EA NA WA CSA 886
    rs617414691,2
    F--139870160(+) TCAGAC/TCCAGA 1 -- us2k11Minor allele frequency- T:0.03NS 74
    rs1855043071,2
    --139870272(+) GTTGGG/TACCTC 1 -- us2k10--------
    rs353811851,2
    C,F--139870346(+) GCAGCG/AGGCAG 1 -- us2k14Minor allele frequency- A:0.02NS NA 172
    rs1409689731,2
    --139870367(+) TTGTGC/GTGATA 1 -- us2k10--------
    rs343575641,2
    C,F--139870382(+) AGCCGC/TAACTC 1 -- us2k14Minor allele frequency- T:0.02NS NA 98
    rs8672501,2
    C,F,A,H--139870445(+) CAGGCT/CTGCGG 1 -- us2k111Minor allele frequency- C:0.21NA NS CSA WA EA 465
    rs1896085981,2
    --139870458(+) CACGCA/GGGGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PTGDS (139871956 - 139879887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/36 variations for PTGDS (see all 36):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422220CNV Deletion17116639
    nsv894513CNV Loss21882294
    nsv894483CNV Loss21882294
    dgv8431n71CNV Loss21882294
    nsv894526CNV Loss21882294
    nsv894521CNV Loss21882294
    nsv894503CNV Loss21882294
    dgv8423n71CNV Loss21882294
    nsv894469CNV Loss21882294
    nsv894535CNV Loss21882294


    Human Gene Mutation Database (HGMD): PTGDS
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176803    OMIM disorders: --

    20/66 diseases for PTGDS (see all 66):    About MalaCards
    meninges hemangiopericytoma    normal pressure hydrocephalus    cerebrospinal fluid leak    egg allergy
    complete androgen insensitivity syndrome    macular holes    proliferative diabetic retinopathy    hemangiopericytoma
    sandhoff disease    ocular hypotension    hydrocephalus    breast cyst
    androgen insensitivity syndrome    arachnoiditis    diabetic retinopathy    aggressive periodontitis
    demyelinating polyneuropathy    traumatic brain injury    mediastinitis    azoospermia

    4 diseases from the University of Copenhagen DISEASES database for PTGDS:
    Asthma     Allergic rhinitis     Ocular hypotension     Vascular disease

    PTGDS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/30 Novoseek inferred disease relationships for PTGDS gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbohydrate-deficient glycoprotein syndrome 57.6 1 9455908 (1)
    hydrocephalus normal pressure 38.6 2 14630351 (2)
    nasal polyps 32.7 6 16911359 (4), 17638783 (1)
    neurological disorders 32.1 5 16259013 (2), 11669522 (2), 11058767 (1)
    azoospermia 30.9 2 18206953 (1), 15748601 (1)
    proliferative diabetic retinopathy 27.2 1 16531280 (1)
    macular holes 25.5 1 16531280 (1)
    multiple sclerosis 22 2 16409554 (1), 16410653 (1)
    aqueous humor 16.8 2 8599604 (1), 12020781 (1)
    renal disease 14.1 2 12194921 (1), 11058767 (1)

    Genetic Association Database (GAD): PTGDS
    Human Genome Epidemiology (HuGE) Navigator: PTGDS (9 documents)

    Export disorders for PTGDS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGDS gene, integrated from 9 sources (see all 226):
    (articles sorted by number of sources associating them with PTGDS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. (PubMed id 1902577)1, 2, 3 Nagata A....Hayaishi O. (1991)
    2. Astrocytes synthesize and secrete prostaglandin D synthetase in vitro. (PubMed id 8599604)1, 2, 9 Giacomelli S.... Cheng C.Y. (1996)
    3. Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. (PubMed id 9065498)1, 2, 9 Yamashima T.... Hayaishi O. (1997)
    4. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. (PubMed id 9475419)1, 2, 9 Tokugawa Y....Hayaishi O. (1998)
    5. Quantification of prostaglandin D synthetase in cerebrospinal fluid: a potential marker for brain tumor. (PubMed id 9844724)1, 2, 9 Saso L.... Cheng C.Y. (1998)
    6. Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia. (PubMed id 17230501)1, 4, 9 Ruano D....Almeida Palha J. (2007)
    7. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PubMed id 19276290)1, 4, 9 Abraham J.E....Pharoah P.D. (2009)
    8. Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients. (PubMed id 15325247)1, 4, 9 Miwa Y....Kawano Y. (2004)
    9. Lipocalin-type prostaglandin D synthase in essential hypertension. (PubMed id 11882588)1, 2, 9 Hirawa N.... Umemura S. (2002)
    10. Charge microheterogeneity of the beta-trace proteins (lipocalin-type prostaglandin D synthase) in the cerebrospinal fluid of patients with neurological disorders analyzed by capillary isoelectrofocusing. (PubMed id 11669522)1, 2, 9 Hiraoka A....Baba K. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5730 HGNC: 9592 AceView: PTGDSandFLJ45224 Ensembl:ENSG00000107317 euGenes: HUgn5730
    ECgene: PTGDS Kegg: 5730 H-InvDB: PTGDS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGDS Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/ptgds/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTGDS gene:
    Search GeneIP for patents involving PTGDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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