Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PTGDR2 Gene

Aliases for PTGDR2 Gene

  • Prostaglandin D2 Receptor 2 2 3
  • Chemoattractant Receptor Homologous Molecule Expressed On T Helper Type 2 Cells 2 3
  • G Protein-Coupled Receptor 44 2 3
  • G-Protein Coupled Receptor 44 3 4
  • GPR44 3 4
  • CRTH2 3 4
  • DL1R 3 4
  • Chemoattractant Receptor-Homologous Molecule Expressed On TH2 Cells 3
  • Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells 4
  • Putative G-Protein Coupled Receptor 44 3
  • CD294 Antigen 4
  • CD294 3
  • DP2 3

External Ids for PTGDR2 Gene

Previous HGNC Symbols for PTGDR2 Gene

  • GPR44

Previous GeneCards Identifiers for PTGDR2 Gene

  • GC11M060619

Summaries for PTGDR2 Gene

Entrez Gene Summary for PTGDR2 Gene

  • This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]

GeneCards Summary for PTGDR2 Gene

PTGDR2 (Prostaglandin D2 Receptor 2) is a Protein Coding gene. Diseases associated with PTGDR2 include nut allergic reaction and eosinophilic pustular folliculitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for PTGDR2 Gene

  • Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

Gene Wiki entry for PTGDR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGDR2 Gene

Genomics for PTGDR2 Gene

Genomic Location for PTGDR2 Gene

Chromosome:
11
Start:
60,850,925 bp from pter
End:
60,855,971 bp from pter
Size:
5,047 bases
Orientation:
Minus strand

Genomic View for PTGDR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGDR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGDR2 Gene

No data available for Regulatory Elements for PTGDR2 Gene

Proteins for PTGDR2 Gene

  • Protein details for PTGDR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y4-PD2R2_HUMAN
    Recommended name:
    Prostaglandin D2 receptor 2
    Protein Accession:
    Q9Y5Y4
    Secondary Accessions:
    • O94765
    • Q4QRI6

    Protein attributes for PTGDR2 Gene

    Size:
    395 amino acids
    Molecular mass:
    43268 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD21055.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD21055.1; Type=Frameshift; Positions=375; Evidence={ECO:0000305};

neXtProt entry for PTGDR2 Gene

Proteomics data for PTGDR2 Gene at MOPED

Post-translational modifications for PTGDR2 Gene

Other Protein References for PTGDR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PTGDR2 Gene

Domains & Families for PTGDR2 Gene

Protein Domains for PTGDR2 Gene

Suggested Antigen Peptide Sequences for PTGDR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y4

UniProtKB/Swiss-Prot:

PD2R2_HUMAN :
  • The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGDR2: view

Function for PTGDR2 Gene

Molecular function for PTGDR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

Gene Ontology (GO) - Molecular Function for PTGDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001785 prostaglandin J receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IDA 11208866
GO:0004956 prostaglandin D receptor activity IDA 11208866
GO:0004958 prostaglandin F receptor activity IEA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with PTGDR2: view
genes like me logo Genes that share phenotypes with PTGDR2: view

Animal Models for PTGDR2 Gene

MGI Knock Outs for PTGDR2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGDR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PTGDR2 Gene

Localization for PTGDR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGDR2 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269 PubMed:17207480}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGDR2 Gene COMPARTMENTS Subcellular localization image for PTGDR2 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PTGDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 11208866
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10036181
GO:0016021 integral component of membrane --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with PTGDR2: view

Pathways & Interactions for PTGDR2 Gene

genes like me logo Genes that share pathways with PTGDR2: view

Pathways by source for PTGDR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PTGDR2 Gene

Gene Ontology (GO) - Biological Process for PTGDR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IDA 11208866
GO:0006955 immune response TAS 9973380
GO:0007186 G-protein coupled receptor signaling pathway IDA 11208866
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PTGDR2: view

No data available for SIGNOR curated interactions for PTGDR2 Gene

Drugs & Compounds for PTGDR2 Gene

(24) Drugs for PTGDR2 Gene - From: IUPHAR, DGIdb, DrugBank, NovoSeek, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor, inhibitor, Target, other/unknown Cox inhibitor 97
Sulindac Approved Pharma Target, antagonist Anti-inflammatory agent;COX inhibitor 35
arachidonic acid Experimental Nutra Potentiation, Activator 27
zomepirac Withdrawn Pharma Target 0
Ramatroban Pharma Antagonist, antagonist 1

(9) Additional Compounds for PTGDR2 Gene - From: NovoSeek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
13,14-dihydro-15-keto-PGF<sub>2alpha</sub>
Full agonist, Agonist
15-deoxy-Delta<sup>12,14</sup>-PGJ<sub>2</sub>
Full agonist, Agonist
Delta<sup>12</sup>-PGJ<sub>2</sub>
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
Allergens
genes like me logo Genes that share compounds with PTGDR2: view

Transcripts for PTGDR2 Gene

mRNA/cDNA for PTGDR2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(58) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGDR2 Gene

Prostaglandin D2 receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PTGDR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGDR2 Gene

No ASD Table

Relevant External Links for PTGDR2 Gene

GeneLoc Exon Structure for
PTGDR2
ECgene alternative splicing isoforms for
PTGDR2

Expression for PTGDR2 Gene

mRNA expression in normal human tissues for PTGDR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGDR2 Gene

This gene is overexpressed in Colon - Transverse (x7.2), Stomach (x5.9), Heart - Left Ventricle (x4.5), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for PTGDR2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGDR2 Gene



SOURCE GeneReport for Unigene cluster for PTGDR2 Gene Hs.299567

mRNA Expression by UniProt/SwissProt for PTGDR2 Gene

Q9Y5Y4-PD2R2_HUMAN
Tissue specificity: Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.
genes like me logo Genes that share expression patterns with PTGDR2: view

Protein tissue co-expression partners for PTGDR2 Gene

Primer Products

In Situ Assay Products

Orthologs for PTGDR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGDR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR44 35
  • 86.63 (n)
  • 83.25 (a)
PTGDR2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR44 35
  • 86.92 (n)
  • 85.38 (a)
CRTH2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr44 35
  • 81.97 (n)
  • 80.47 (a)
Gpr44 16
Gpr44 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR44 35
  • 99.41 (n)
  • 99.49 (a)
PTGDR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgdr2 35
  • 81.44 (n)
  • 80.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PTGDR2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGDR2 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AL954173.1 36
  • 21 (a)
ManyToMany
Species with no ortholog for PTGDR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGDR2 Gene

ENSEMBL:
Gene Tree for PTGDR2 (if available)
TreeFam:
Gene Tree for PTGDR2 (if available)

Paralogs for PTGDR2 Gene

(12) SIMAP similar genes for PTGDR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTGDR2: view

Variants for PTGDR2 Gene

Sequence variations from dbSNP and Humsavar for PTGDR2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs503207 -- 60,855,397(-) TCTGG(C/T)GGTGC intron-variant
rs506822 -- 60,855,605(-) CAGCA(C/G)GCTTA intron-variant
rs530539 -- 60,855,299(+) CACCC(C/G)CTGTC intron-variant
rs545659 -- 60,852,184(-) AACTC(A/G)TAATA utr-variant-3-prime
rs553056 -- 60,856,948(+) AATTT(A/T)AACTA upstream-variant-2KB

Variation tolerance for PTGDR2 Gene

Gene Damage Index Score: 2.81; 47.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGDR2 Gene

HapMap Linkage Disequilibrium report
PTGDR2
Human Gene Mutation Database (HGMD)
PTGDR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTGDR2 Gene

Disorders for PTGDR2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PTGDR2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
nut allergic reaction
  • allergy to nuts other than peanuts
eosinophilic pustular folliculitis
  • eosinophilic folliculitis, pustular
folliculitis
  • seborrhea capitis
mikulicz disease
  • mikulicz's disease
nasal cavity disease
  • nasal cavity disease nos
- elite association

Relevant External Links for PTGDR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGDR2
genes like me logo Genes that share disorders with PTGDR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGDR2 Gene

Publications for PTGDR2 Gene

  1. Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2. (PMID: 15870392) Mathiesen J.M. … Kostenis E. (Mol. Pharmacol. 2005) 23 25 67
  2. Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists. (PMID: 20137942) Grimstrup M. … HAPgberg T. (Bioorg. Med. Chem. Lett. 2010) 23 67
  3. Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1. (PMID: 20031403) Rist A.9. … HAPgberg T. (Bioorg. Med. Chem. Lett. 2010) 23 67
  4. Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. (PMID: 20107720) Satoh T. … Yokozeki H. (Acta Derm. Venereol. 2010) 23 67
  5. Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2. (PMID: 20022749) Grimstrup M. … HAPgberg T. (Bioorg. Med. Chem. Lett. 2010) 23 67

Products for PTGDR2 Gene

Sources for PTGDR2 Gene

Back to Top

Content