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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGDR Gene

protein-coding   GIFtS: 67
GCID: GC14P052734

prostaglandin D2 receptor (DP)
 Explore 27 diseases affiliated with
PTGDR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PTGDR    

Aliases
for PTGDR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Prostaglandin D2 Receptor (DP)1 2     PGD2 Receptor2 3
DP1 2     AS12 5
DP11 2     ASRT12 5
PTGDR11 2     Prostaglandin D2 Receptor2
PGD Receptor2 3     Prostanoid DP Receptor3

External Ids:    HGNC: 95911   Entrez Gene: 57292   Ensembl: ENSG000001682297   OMIM: 6046875   UniProtKB: Q132583   

Export aliases for PTGDR gene to outside databases

Previous GC identifers: GC14P050057 GC14P046530 GC14P050724 GC14P051804 GC14P032895


Summaries
for PTGDR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PTGDR:
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP
receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting
in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor,
prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
Function: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that
stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also
observed, but without formation of inositol 1,4,5-trisphosphate (By similarity)

summary for PTGDR:
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. DP receptors (DP1-2) are coupled to Galphas.
They are expressed in the small intestine, lung, stomach and uterus. Activation of DP1 results in inhibition
of platelet activation, vasodilation, and they are involved in sleep regulation. DP2 activation leads to
immune cell activation.

Gene Wiki entry for PTGDR (Prostaglandin D2 receptor)


Genomic Views
for PTGDR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGDR gene promoter:
         GR   Egr-3   AML1a   Nkx2-5   MIF-1   HEN1   Egr-2   c-Rel   IRF-7A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTGDR promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGDR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGDR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

PTGDR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGDR gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P052734:  view genomic region     (about GC identifiers)

Start:
 52,734,431 bp from pter      End:
 52,743,442 bp from pter
Size:
 9,012 bases      Orientation:
 plus strand

Proteins
for PTGDR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258 (See protein sequence)
Recommended Name: Prostaglandin D2 receptor  
Size: 359 amino acids; 40271 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q13250 Q13251 Q1ZZ52

Explore the universe of human proteins at neXtProt for PTGDR: NX_Q13258

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13258

    • PTGDR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000944.1  
    ENSEMBL proteins: 
     ENSP00000303424   ENSP00000452408  
    Reactome Protein details: Q13258
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PTGDR Protein
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    Novus Biologicals PTGDR Protein
    Novus Biologicals PTGDR Lysates
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    Uscn Proteins for PTGDR

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS7642548


    PTGDR for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PTGDR

    Protein Domains /
    Families
    for PTGDR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PTGDR for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008365 Prostanoid_rcpt
     IPR000376 Pglndn_D_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q13258

    ProtoNet protein and cluster: Q13258

    1 Blocks protein family: IPB000376 Prostaglandin D receptor signature

    UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for PTGDR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
    Function: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that
    stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also
    observed, but without formation of inositol 1,4,5-trisphosphate (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTGDR
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGDR (see all 39):
    hsa-miR-302d hsa-miR-520e hsa-miR-4328 hsa-miR-631 hsa-miR-513a-5p hsa-miR-106a hsa-miR-128 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: PTGDR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGDR (see all 4)
    OriGene shRNA RFP: PTGDR
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for PTGDR

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001785prostaglandin J receptor activity IEA--
    GO:0004956prostaglandin D receptor activity NAS7642548
    GO:0005515protein binding IPI--


    PTGDR for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PTGDR:
     Decreased Wnt reporter activit  Increased cell number in G1, a  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Ptgdrtm1Sna for PTGDR
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ptgdr):
     behavior/neurological  immune system  mortality/aging  nervous system  respiratory system 

    PTGDR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PTGDR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		GPCRs, Class A Rhodopsin-like0.41
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    2Prostanoid ligand receptors
    		Prostanoid ligand receptors1.00
    		Small Ligand GPCRs0.42
    		Eicosanoid ligand-binding receptors0.60
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    		Platelet Aggregation Inhibitor Pathway, Pharmacodynamics1.00
    5Celecoxib Pathway, Pharmacodynamics
    		Celecoxib Pathway, Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for PTGDR 
        Prostaglandin Synthesis and Regulation
    GPCRs, Class A Rhodopsin-like
    Thromboxane A2 receptor signaling
    Small Ligand GPCRs

    5/8        Reactome Pathways for PTGDR (see all 8)
        GPCR downstream signaling
    Eicosanoid ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)

    2 PharmGKB Pathways for PTGDR
        Celecoxib Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for PTGDR):
        Neuroactive ligand-receptor interaction


    PTGDR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGDR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for PTGDR (Q132583 ENSP000003034244) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADRB2ENSP000003053724STRING: ENSP00000305372
    AVPR2ENSP000003380724STRING: ENSP00000338072
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway NAS7642548
    GO:0030238male sex determination IEA--
    GO:0030431sleep IEA--
    GO:0046085adenosine metabolic process IEA--


    PTGDR for ontologies           About GeneDecksing



    Drugs & Compounds
    for PTGDR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGDR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PTGDR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-u 3405Dual TP/DP2 (CRTH2) receptor antagonist[116649-85-5]
    AlprostadilProstaglandin. Vasodilator and antiplatelet agent in vivo[745-65-3]

    3 HMDB Compounds for PTGDR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Prostaglandin D2prostaglandin d2 (see all 22)41598-07-6--

    1 DrugBank Compound for PTGDR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nedocromil-- 69049-73-6targetunknown8939179 17139284 17016423 11544467

    10/15 Novoseek chemical compound relationships for PTGDR gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pgd2 95.2 80 18802357 (4), 12148545 (4), 17207480 (4), 17307163 (4) (see all 48)
    bw245c 94.5 6 11082108 (1), 12494276 (1), 11742277 (1), 16272307 (1) (see all 5)
    13,14-dihydro-15-keto-pgd2 93.2 3 11742277 (1), 16272307 (1)
    ramatroban 92.9 3 15179446 (1), 15298571 (1)
    bwa868c 92.3 1 11082108 (1)
    norbornane 82 1 9357516 (1)
    prostaglandin 71.7 11 7492609 (1), 9758211 (1), 12429577 (1), 15298571 (1) (see all 6)
    thromboxane a2 63 5 7492609 (1), 15179446 (1), 9284401 (1), 17154652 (1)
    thromboxane 59.9 2 12429577 (1), 8661119 (1)
    prostacyclin 57.7 6 1775633 (2), 7492609 (1), 9284401 (1), 9758211 (1)

    Search CenterWatch for drugs/clinical trials and news about PTGDR / PD2R 

    Transcripts
    for PTGDR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PTGDR gene: 
    NM_000953.2  

    Unigene Cluster for PTGDR:

    Prostaglandin D2 receptor (DP)
    Hs.306831  [show with all ESTs]
    Unigene Representative Sequence: BC040968
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306051(uc001wzq.3) ENST00000553372

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PTGDR (see all 39):
    hsa-miR-302d hsa-miR-520e hsa-miR-4328 hsa-miR-631 hsa-miR-513a-5p hsa-miR-106a hsa-miR-128 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: PTGDR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTGDR (see all 4)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK026202.1 BC040968.1 EF577397.1 U31099.1 

    1 DOTS entry:

    DT.95149520 

    10 AceView cDNA sequences:

    NM_000953 U31099 CD013871 BX498371 BQ068035 BC040968 AW841947 AI460323 
    AW841862 AK026202 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PTGDR    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for PTGDR

    Expression
    for PTGDR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGDR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTTGTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PTGDR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadGonad Somatic CellsOvary, Testis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PTGDR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGDR

    SOURCE GeneReport for Unigene cluster: Hs.306831

    UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
    Tissue specificity: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris,
    small intestine and platelet membranes

        SABiosciences Expression via Pathway-Focused PCR Arrays including PTGDR: 
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              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for PTGDR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PTGDR gene from 1/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG74976
    		 --
    		 17(a)
    		 possible ortholog
    		 3L(17626549-17630975)


    ENSEMBL Gene Tree for PTGDR (if available)
    TreeFam Gene Tree for PTGDR (if available) 

    Paralogs
    for PTGDR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGDR gene
    PTGER12  PTGER42  PTGER32  PTGFR2  PTGER22  TBXA2R2  PTGIR2  
    3 SIMAP similar genes for PTGDR using alignment to 2 protein entries:     PD2R_HUMAN (see all proteins):
    PTGER2    PTGIR    PTGER4

    PTGDR for paralogs           About GeneDecksing



    Genomic Variants
    for PTGDR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/427 NCBI SNPs in PTGDR are shown (see all 427)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs780854161,2
    		C,F,--32893218(+) GTCTGT/CCTGTC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs8030121,2
    		C,F,A,H,--32893397(-) NNNNTT/CGTATA 1 -- us2k118Minor allele frequency- C:0.13NS EA NA WA 1976
    rs799575681,2
    		F,--32893566(+) CCATTA/CGGTTG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs413113501,2
    		C,F,--32893700(+) TCTCTG/CTCTAC 1 -- us2k14Minor allele frequency- C:0.07NS WA 212
    rs111579061,2
    		C,F,A,H,--32893704(+) TGTCTA/GCCCTT 1 -- us2k112Minor allele frequency- G:0.15NA NS CSA WA 524
    rs101380411,2
    		C,--32894095(+) AAACAC/ACCTTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs413871521,2
    		C,F,--32894344(+) AGTCAA/GTGTGA 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs8030111,2
    		C,F,--32894373(-) GAGCCG/AGTGTT 1 -- us2k18Minor allele frequency- A:0.15NA NS WA 340
    rs413113521,2
    		C,F,--32894396(+) CAAACC/GACTTC 1 -- us2k12Minor allele frequency- G:0.02NS 94
    rs413113541,2
    		C,--32894576(+) ATGACC/TGTGAA 1 -- us2k12Minor allele frequency- T:0.01NS 92

    HapMap Linkage Disequilibrium report for PTGDR (52734431 - 52743442 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PTGDR
         1 CNV: 58677
    Human Gene Mutation Database (HGMD): PTGDR

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    Disorders / Diseases
    for PTGDR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PTGDR for disorders           About GeneDecksing

    OMIM gene information: 604687   
    OMIM disorders: 607277  
    UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
  • Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1)
    • [MIM:607277]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea

    20/27 diseases for PTGDR (see all 27):    About MalaCards
    pre-eclampsia    allergic rhinitis    bronchial asthma    atopic dermatitis
    asthma    cowpox    smallpox    epithelial ovarian cancer
    osteomyelitis    rhinitis    eye disease    eclampsia
    dermatitis    ovarian cancer    atopy    hepatitis b
    rabies    vaccinia    choroiditis    meningioma

    1 disease from the University of Copenhagen DISEASES database for PTGDR:
    Asthma

    2 Novoseek disease relationships for PTGDR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 47.4 29 15496624 (5), 19748656 (3), 16629782 (3), 12002745 (2) (see all 12)
    inflammation 29.8 4 12148545 (1), 18691063 (1), 16888024 (1)

    Genetic Association Database (GAD): PTGDR
    Human Genome Epidemiology (HuGE) Navigator: PTGDR (26 documents)

    Export disorders for PTGDR gene to outside databases

    Publications
    for PTGDR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGDR gene, integrated from 9 sources (see all 128):
    (articles sorted by number of sources associating them with PTGDR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of prostanoid DP receptor variants in susceptibility to asthma. (PubMed id 15496624)1, 2, 4, 9 Oguma T.... Lilly C.M. (2004)
    2. Molecular cloning and characterization of the human prostanoid DP receptor. (PubMed id 7642548)1, 2, 3, 9 Boie Y.... Abramovitz M. (1995)
    3. New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes. (PubMed id 12002745)1, 4, 9 Noguchi E....Arinami T. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. (PubMed id 18802357)1, 9 Yamamoto M....Nishizaki K. (2009)
    6. Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. (PubMed id 17307163)1, 9 Hirano Y....Arimura A. (2007)
    7. Promoter genetic variants of prostanoid DP receptor (PTGDR) gene in patients with asthma. (PubMed id 16629782)1, 9 Sanz C....Lorente F. (2006)
    8. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. (PubMed id 11742277)1, 9 Gervais F.G....O'neill G.P. (2001)
    9. Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis. (PubMed id 19748656)1, 9 Philip G....Reiss T.F. (2009)
    10. Prostanoid DP receptor (PTGDR) variants in mothers wi th post-coital associated preterm births: preliminary observations. (PubMed id 19710676)1, 9 Grisaru-Granovsky S....Schimmel M.S. (2010)

    External Searches for PTGDR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PTGDR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5729 HGNC: 9591 AceView: PTGDR Ensembl:ENSG00000168229 euGenes: HUgn5729
    ECgene: PTGDR Kegg: 5729 H-InvDB: PTGDR

    Other Databases showing PTGDR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PTGDR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGDR Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/apobec3f/

    Intellectual Property
    for PTGDR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PTGDR gene:
    Search GeneIP for patents involving PTGDR

    GeneCards and IP:
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