Aliases for PTGDR Gene
External Ids for PTGDR Gene
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PTGDR Gene
PTGDR (Prostaglandin D2 Receptor (DP)) is a Protein Coding gene. Diseases associated with PTGDR include asthma 1 and asthma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include prostaglandin J receptor activity and prostaglandin D receptor activity. An important paralog of this gene is TBXA2R.
UniProtKB/Swiss-Prot for PTGDR Gene
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions. DP receptors (DP1-2) are coupled to Galphas. They are expressed in the small intestine, lung, stomach and uterus. Activation of DP1 results in inhibition of platelet activation, vasodilation, and they are involved in sleep regulation. DP2 activation leads to immune cell activation.