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Aliases for PTGDR Gene

Aliases for PTGDR Gene

  • Prostaglandin D2 Receptor 2 3 5
  • PGD2 Receptor 3 4
  • Prostanoid DP Receptor 4
  • PGD Receptor 4
  • PTGDR1 3
  • ASRT1 3
  • AS1 3
  • DP1 3
  • DP 3

External Ids for PTGDR Gene

Previous GeneCards Identifiers for PTGDR Gene

  • GC14P050057
  • GC14P046530
  • GC14P050724
  • GC14P051804
  • GC14P052734
  • GC14P032895

Summaries for PTGDR Gene

Entrez Gene Summary for PTGDR Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTGDR Gene

PTGDR (Prostaglandin D2 Receptor) is a Protein Coding gene. Diseases associated with PTGDR include Asthma 1 and Rosacea. Among its related pathways are Signaling by GPCR and Eicosanoid ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and prostaglandin D receptor activity. An important paralog of this gene is PTGER2.

UniProtKB/Swiss-Prot for PTGDR Gene

  • Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

Tocris Summary for PTGDR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGDR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGDR Gene

Genomics for PTGDR Gene

Regulatory Elements for PTGDR Gene

Enhancers for PTGDR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F052265 1.2 FANTOM5 Ensembl ENCODE 19.5 -1.1 -1102 1.9 ZBTB33 ZNF384 GABPA PTGDR PTGER2 ENSG00000258440
GH14F052267 0.2 ENCODE 19.5 +0.4 352 0.2 SUZ12 CBX2 PTGDR LOC105370495 LOC100131689
GH14F052271 0.5 FANTOM5 15.7 +4.5 4521 0.3 NFIA PBX2 ATF2 PTGDR GNG2 PTGER2 LOC100131689
GH14F052240 1.3 Ensembl ENCODE 12.1 -25.7 -25744 1.8 TBP PKNOX1 NFRKB SIN3A RAD21 ZNF48 YY1 ZNF335 ZNF766 GATA4 PTGDR ENSG00000258440
GH14F052234 0.6 Ensembl 12.1 -31.9 -31856 1.2 ZBTB33 CREM ZNF652 PTGDR ENSG00000258440
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PTGDR on UCSC Golden Path with GeneCards custom track

Promoters for PTGDR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001789189 1444 2200 ZNF263 RNF2 SUZ12 GLIS1 CBX2 ZBTB33 EZH2

Genomic Location for PTGDR Gene

Chromosome:
14
Start:
52,267,256 bp from pter
End:
52,276,724 bp from pter
Size:
9,469 bases
Orientation:
Plus strand

Genomic View for PTGDR Gene

Genes around PTGDR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGDR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGDR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGDR Gene

Proteins for PTGDR Gene

  • Protein details for PTGDR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13258-PD2R_HUMAN
    Recommended name:
    Prostaglandin D2 receptor
    Protein Accession:
    Q13258
    Secondary Accessions:
    • G3V5L3
    • Q13250
    • Q13251
    • Q1ZZ52

    Protein attributes for PTGDR Gene

    Size:
    359 amino acids
    Molecular mass:
    40271 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTGDR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGDR Gene

Post-translational modifications for PTGDR Gene

  • Glycosylation at Asn 10, Asn 90, and Asn 297
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGDR Gene

No data available for DME Specific Peptides for PTGDR Gene

Domains & Families for PTGDR Gene

Gene Families for PTGDR Gene

Suggested Antigen Peptide Sequences for PTGDR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13258

UniProtKB/Swiss-Prot:

PD2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGDR: view

Function for PTGDR Gene

Molecular function for PTGDR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

Gene Ontology (GO) - Molecular Function for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001785 prostaglandin J receptor activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004956 prostaglandin D receptor activity NAS 7642548
GO:0005515 protein binding IPI 20959461
genes like me logo Genes that share ontologies with PTGDR: view
genes like me logo Genes that share phenotypes with PTGDR: view

Animal Models for PTGDR Gene

MGI Knock Outs for PTGDR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGDR

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGDR

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGDR Gene

Localization for PTGDR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGDR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGDR Gene COMPARTMENTS Subcellular localization image for PTGDR gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 7642548
genes like me logo Genes that share ontologies with PTGDR: view

Pathways & Interactions for PTGDR Gene

genes like me logo Genes that share pathways with PTGDR: view

Gene Ontology (GO) - Biological Process for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 7642548
GO:0007189 NOT adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA --
genes like me logo Genes that share ontologies with PTGDR: view

No data available for SIGNOR curated interactions for PTGDR Gene

Drugs & Compounds for PTGDR Gene

(52) Drugs for PTGDR Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 77
Nedocromil Approved Pharma Target, unknown 5
Misoprostol Approved Pharma 286
Alprostadil Approved, Investigational Pharma Prostaglandin. Vasodilator and antiplatelet agent in vivo 69
cyclic amp Experimental Pharma 0

(14) Additional Compounds for PTGDR Gene - From: HMDB, Novoseek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-deoxy-Delta<sup>12,14</sup>-PGJ<sub>2</sub>
Full agonist, Agonist
Delta<sup>12</sup>-PGJ<sub>2</sub>
Full agonist, Agonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
Prostaglandin D2
  • (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoate
  • (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
  • (5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
  • (5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
  • (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate
41598-07-6

(5) Tocris Compounds for PTGDR Gene

Compound Action Cas Number
Alprostadil Prostaglandin. Vasodilator and antiplatelet agent in vivo 745-65-3
Iloprost Prostacyclin (PGI2) analog 78919-13-8
L-798,106 Potent and highly selective EP3 antagonist 244101-02-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(18) ApexBio Compounds for PTGDR Gene

Compound Action Cas Number
(+)-Fluprostenol 54276-17-4
(±)-Cloprostenol sodium salt 55028-72-3
BMY 45778 Type I IL-1 receptor antagonist 152575-66-1
GW 627368 439288-66-1
L-161,982 147776-06-5
L-655,240 103253-15-2
L-670,596 121083-05-4
L-798,106 244101-02-8
Laropiprant DP1 receptor antagonist,potent and selective 571170-77-9
Misoprostol 59122-46-2
NS 304 475086-01-2
PF 04418948 1078166-57-0
Prostaglandin F2α 38562-01-5
SC 51089 146033-02-5
SC 51322 146032-79-3
Sulprostone 60325-46-4
TCS 2510 346673-06-1
U 46619 selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor 56985-40-1
genes like me logo Genes that share compounds with PTGDR: view

Transcripts for PTGDR Gene

mRNA/cDNA for PTGDR Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGDR Gene

Prostaglandin D2 receptor (DP):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PTGDR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGDR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PTGDR Gene

GeneLoc Exon Structure for
PTGDR
ECgene alternative splicing isoforms for
PTGDR

Expression for PTGDR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGDR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGDR Gene

This gene is overexpressed in Colon - Transverse (x8.6), Whole Blood (x7.0), and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for PTGDR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGDR Gene



Protein tissue co-expression partners for PTGDR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGDR Gene:

PTGDR

SOURCE GeneReport for Unigene cluster for PTGDR Gene:

Hs.306831

mRNA Expression by UniProt/SwissProt for PTGDR Gene:

Q13258-PD2R_HUMAN
Tissue specificity: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.
genes like me logo Genes that share expression patterns with PTGDR: view

Primer Products

Orthologs for PTGDR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGDR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGDR 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia PTGDR 34 35
  • 85.77 (n)
cow
(Bos Taurus)
Mammalia PTGDR 34 35
  • 84.49 (n)
rat
(Rattus norvegicus)
Mammalia Ptgdrl 34
  • 78.25 (n)
mouse
(Mus musculus)
Mammalia Ptgdr 34 16 35
  • 78.06 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgdr 34
  • 56.72 (n)
zebrafish
(Danio rerio)
Actinopterygii ptger4c 35
  • 22 (a)
ManyToMany
Species where no ortholog for PTGDR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGDR Gene

ENSEMBL:
Gene Tree for PTGDR (if available)
TreeFam:
Gene Tree for PTGDR (if available)

Paralogs for PTGDR Gene

Paralogs for PTGDR Gene

(3) SIMAP similar genes for PTGDR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTGDR: view

Variants for PTGDR Gene

Sequence variations from dbSNP and Humsavar for PTGDR Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10138041 -- 52,266,703(+) AAACA(A/C)CCTTC upstream-variant-2KB
rs10146847 -- 52,265,555(+) ATTTG(G/T)AATCT upstream-variant-2KB
rs10498445 -- 52,273,723(+) ATTGC(C/G)TCGAA intron-variant
rs111318202 -- 52,275,470(+) AAGCA(G/T)AGCCT intron-variant, utr-variant-3-prime
rs111453548 -- 52,268,127(+) CGTTG(C/T)GCCAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PTGDR Gene

Variant ID Type Subtype PubMed ID
nsv1044604 CNV gain 25217958
nsv819552 CNV gain 19587683
nsv832795 CNV gain 17160897

Variation tolerance for PTGDR Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PTGDR Gene

Human Gene Mutation Database (HGMD)
PTGDR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGDR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGDR Gene

Disorders for PTGDR Gene

MalaCards: The human disease database

(6) MalaCards diseases for PTGDR Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma 1
  • asthma-related traits 1
rosacea
  • acne rosacea
asthma
  • asthma, protection against
atopy
  • atopic hypersensitivity
anemia of prematurity
- elite association - COSMIC cancer census association via MalaCards
Search PTGDR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PD2R_HUMAN
  • Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:15496624}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for PTGDR

Genetic Association Database (GAD)
PTGDR
Human Genome Epidemiology (HuGE) Navigator
PTGDR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PTGDR
genes like me logo Genes that share disorders with PTGDR: view

No data available for Genatlas for PTGDR Gene

Publications for PTGDR Gene

  1. Role of prostanoid DP receptor variants in susceptibility to asthma. (PMID: 15496624) Oguma T. … Lilly C.M. (N. Engl. J. Med. 2004) 3 4 22 46 64
  2. Molecular cloning and characterization of the human prostanoid DP receptor. (PMID: 7642548) Boie Y. … Abramovitz M. (J. Biol. Chem. 1995) 2 3 4 22 64
  3. Prostanoid DP receptor (PTGDR) variants in mothers with post-coital associated preterm births: preliminary observations. (PMID: 19710676) Grisaru-Granovsky S. … Schimmel M.S. (J Perinatol 2010) 3 22 46 64
  4. PTGDR is not a major candidate gene for asthma and atopy in Chinese children. (PMID: 19220773) Leung T.F. … Chan J.C. (Pediatr Allergy Immunol 2009) 3 22 46 64
  5. Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis. (PMID: 19748656) Philip G. … Reiss T.F. (J. Allergy Clin. Immunol. 2009) 3 22 46 64

Products for PTGDR Gene

Sources for PTGDR Gene

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