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Aliases for PTGDR Gene

Aliases for PTGDR Gene

  • Prostaglandin D2 Receptor (DP) 2 3
  • PGD2 Receptor 3 4
  • ASRT1 3 6
  • AS1 3 6
  • Prostaglandin D2 Receptor 3
  • Prostanoid DP Receptor 4
  • PGD Receptor 4
  • PTGDR1 3
  • DP1 3
  • DP 3

External Ids for PTGDR Gene

Summaries for PTGDR Gene

Entrez Gene Summary for PTGDR Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTGDR Gene

PTGDR (Prostaglandin D2 Receptor (DP)) is a Protein Coding gene. Diseases associated with PTGDR include asthma 1 and asthma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include prostaglandin J receptor activity and prostaglandin D receptor activity. An important paralog of this gene is TBXA2R.

UniProtKB/Swiss-Prot for PTGDR Gene

  • Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

Tocris Summary for PTGDR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions. DP receptors (DP1-2) are coupled to Galphas. They are expressed in the small intestine, lung, stomach and uterus. Activation of DP1 results in inhibition of platelet activation, vasodilation, and they are involved in sleep regulation. DP2 activation leads to immune cell activation.

Gene Wiki entry for PTGDR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGDR Gene

Genomics for PTGDR Gene

Genomic Location for PTGDR Gene

Start:
52,267,592 bp from pter
End:
52,277,090 bp from pter
Size:
9,499 bases
Orientation:
Plus strand

Genomic View for PTGDR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PTGDR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGDR Gene

Regulatory Elements for PTGDR Gene

Proteins for PTGDR Gene

  • Protein details for PTGDR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13258-PD2R_HUMAN
    Recommended name:
    Prostaglandin D2 receptor
    Protein Accession:
    Q13258
    Secondary Accessions:
    • G3V5L3
    • Q13250
    • Q13251
    • Q1ZZ52

    Protein attributes for PTGDR Gene

    Size:
    359 amino acids
    Molecular mass:
    40271 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTGDR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGDR Gene

Proteomics data for PTGDR Gene at MOPED

Post-translational modifications for PTGDR Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn10, Asn90, and Asn297

Other Protein References for PTGDR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGDR Gene

Domains for PTGDR Gene

Gene Families for PTGDR Gene

HGNC:
  • PTGR :GPCR / Class A : Prostanoid receptors
IUPHAR :

Protein Domains for PTGDR Gene

UniProtKB/Swiss-Prot:

PD2R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q13258
genes like me logo Genes that share domains with PTGDR: view

Function for PTGDR Gene

Molecular function for PTGDR Gene

UniProtKB/Swiss-Prot Function: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

Gene Ontology (GO) - Molecular Function for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001785 prostaglandin J receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
GO:0004956 prostaglandin D receptor activity NAS 7642548
GO:0005515 protein binding IPI 20959461
genes like me logo Genes that share ontologies with PTGDR: view
genes like me logo Genes that share phenotypes with PTGDR: view

Animal Models for PTGDR Gene

MGI Knock Outs for PTGDR:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PTGDR Gene

Localization for PTGDR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGDR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PTGDR Gene COMPARTMENTS Subcellular localization image for PTGDR gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 7642548
genes like me logo Genes that share ontologies with PTGDR: view

Pathways for PTGDR Gene

genes like me logo Genes that share pathways with PTGDR: view

Gene Ontology (GO) - Biological Process for PTGDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 7642548
GO:0030238 male sex determination IEA --
GO:0030431 sleep IEA --
GO:0046085 adenosine metabolic process IEA --
genes like me logo Genes that share ontologies with PTGDR: view

Compounds for PTGDR Gene

(5) Tocris Compounds for PTGDR Gene

Compound Action Cas Number
Iloprost Prostacyclin (PGI2) analog [78919-13-8]
L-161,982 Selective EP4 receptor antagonist [147776-06-5]
L-798,106 Potent and highly selective EP3 antagonist [244101-02-8]
Prostaglandin E2 Major endogenous prostanoid [363-24-6]
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]

(3) HMDB Compounds for PTGDR Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
Prostaglandin D2
  • prostaglandin d2
41598-07-6

(1) Drugbank Compounds for PTGDR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Nedocromil
69049-73-6 target unknown

(24) IUPHAR Ligand for PTGDR Gene

Ligand Type Action Affinity Pubmed IDs
[3H]PGD2 Agonist Full agonist 9.5
BW 245C Agonist Full agonist 9.4
BWA868C Antagonist Antagonist 9.3
L-644,698 Agonist Full agonist 9.3
PGJ2 Agonist Full agonist 9
[3H]BWA868C Antagonist Antagonist 8.8
SQ-27986 Agonist Full agonist 8
S-5751 Antagonist Antagonist 7.6
RS 93520 Agonist Partial agonist 7.5
U46619 Agonist Full agonist 7.5
L-888,291 Agonist Full agonist 7.4
ZK118182 Agonist Partial agonist 7.1
Delta12-PGJ2 Agonist Full agonist 7
ZK110841 Agonist Partial agonist 6.8
15-deoxy-Delta12,14-PGJ2 Agonist Full agonist 6.6
PGE1 Activator Full agonist 6.3
AH6809 Antagonist Antagonist 6
iloprost Agonist Full agonist 5.2
cloprostenol Agonist Full agonist 5.2
PGF2alpha Agonist Full agonist 5.1
PGD2 Agonist Full agonist 4.7
carbacyclin Agonist Full agonist 4.7
butaprost (free acid form) Agonist Full agonist 4.7
PGE2 Agonist Full agonist 4.5

(15) Novoseek inferred chemical compound relationships for PTGDR Gene

Compound -log(P) Hits PubMed IDs
pgd2 95.2 66
bw245c 94.5 5
13,14-dihydro-15-keto-pgd2 93.2 2
ramatroban 92.9 2
bwa868c 92.3 1
genes like me logo Genes that share compounds with PTGDR: view

Transcripts for PTGDR Gene

mRNA/cDNA for PTGDR Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGDR Gene

Prostaglandin D2 receptor (DP):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTGDR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PTGDR Gene

GeneLoc Exon Structure for
PTGDR
ECgene alternative splicing isoforms for
PTGDR

Expression for PTGDR Gene

mRNA expression in normal human tissues for PTGDR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGDR Gene

This gene is overexpressed in Colon - Transverse (8.6), Whole Blood (7.0), and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PTGDR Gene

SOURCE GeneReport for Unigene cluster for PTGDR Gene Hs.306831

mRNA Expression by UniProt/SwissProt for PTGDR Gene

Q13258-PD2R_HUMAN
Tissue specificity: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.
genes like me logo Genes that share expressions with PTGDR: view

Orthologs for PTGDR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGDR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGDR 36
  • 99.34 (n)
  • 98.57 (a)
PTGDR 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTGDR 36
  • 84.49 (n)
  • 79.94 (a)
PTGDR 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTGDR 36
  • 85.77 (n)
  • 82.87 (a)
PTGDR 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgdr 36
  • 78.06 (n)
  • 74.36 (a)
Ptgdr 16
Ptgdr 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptgdrl 36
  • 78.25 (n)
  • 77.21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptgdr 36
  • 56.72 (n)
  • 55.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ptger4c 37
  • 22 (a)
ManyToMany
Species with no ortholog for PTGDR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGDR Gene

ENSEMBL:
Gene Tree for PTGDR (if available)
TreeFam:
Gene Tree for PTGDR (if available)

Paralogs for PTGDR Gene

Paralogs for PTGDR Gene

Selected SIMAP similar genes for PTGDR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PTGDR: view

Variants for PTGDR Gene

Sequence variations from dbSNP and Humsavar for PTGDR Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs708486 -- 52,274,253(-) TGTCA(C/T)ATGTA intron-variant
rs708487 -- 52,274,363(-) CTTTC(C/T)AGCTA intron-variant
rs802986 -- 52,275,996(-) ACCGT(C/G)TCCAC utr-variant-3-prime
rs802987 -- 52,275,651(-) AAAAA(C/T)GAATT utr-variant-3-prime, intron-variant
rs803006 -- 52,271,305(-) TGGGA(A/C)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTGDR Gene

Variant ID Type Subtype PubMed ID
nsv832795 CNV Gain 17160897
nsv819552 CNV Gain 19587683

Relevant External Links for PTGDR Gene

HapMap Linkage Disequilibrium report
PTGDR
Human Gene Mutation Database (HGMD)
PTGDR

Disorders for PTGDR Gene

(1) OMIM Diseases for PTGDR Gene (604687)

UniProtKB/Swiss-Prot

PD2R_HUMAN
  • Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:15496624}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) MalaCards Diseases for PTGDR Gene

Search for PTGDR Gene in MalaCards »

(1) University of Copenhagen DISEASES for PTGDR Gene

(2) Novoseek inferred disease relationships for PTGDR Gene

Disease -log(P) Hits PubMed IDs
asthma 47.4 21
inflammation 29.8 3

Relevant External Links for PTGDR

Genetic Association Database (GAD)
PTGDR
Human Genome Epidemiology (HuGE) Navigator
PTGDR
genes like me logo Genes that share disorders with PTGDR: view

Publications for PTGDR Gene

  1. Molecular cloning and characterization of the human prostanoid DP receptor. (PMID: 7642548) Boie Y. … Abramovitz M. (J. Biol. Chem. 1995) 2 3 4 23
  2. Role of prostanoid DP receptor variants in susceptibility to asthma. (PMID: 15496624) Oguma T. … Lilly C.M. (N. Engl. J. Med. 2004) 3 4 23 49
  3. Promoter genetic variants of prostanoid DP receptor (PTGDR) gene in patients with asthma. (PMID: 16629782) Sanz C. … Lorente F. (Allergy 2006) 3 23 49
  4. The PTGDR gene is not associated with asthma in 3 ethnically diverse populations. (PMID: 17157653) Tsai Y.J. … . (J. Allergy Clin. Immunol. 2006) 3 23 49
  5. Association of PTGDR gene polymorphisms with asthma in two Caucasian populations. (PMID: 17538632) Zhu G. … Pillai S.G. (Genes Immun. 2007) 3 23 49

Products for PTGDR Gene

Sources for PTGDR Gene

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