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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTGDR Gene

protein-coding   GIFtS: 67
GCID: GC14P052734

Prostaglandin D2 Receptor (DP)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prostaglandin D2 Receptor (DP)1 2     DP12
PGD2 Receptor2 3     PTGDR12
AS12 5     Prostaglandin D2 Receptor2
ASRT12 5     PGD Receptor3
DP2     Prostanoid DP Receptor3

External Ids:    HGNC: 95911   Entrez Gene: 57292   Ensembl: ENSG000001682297   OMIM: 6046875   UniProtKB: Q132583   

Export aliases for PTGDR gene to outside databases

Previous GC identifers: GC14P050057 GC14P046530 GC14P050724 GC14P051804 GC14P032895


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTGDR Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR)
superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate
intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which
is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for PTGDR Gene: 
PTGDR (prostaglandin D2 receptor (DP)) is a protein-coding gene. Diseases associated with PTGDR include smallpox, and cowpox, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Eicosanoid ligand-binding receptors. GO annotations related to this gene include prostaglandin J receptor activity and prostaglandin D receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
Function: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins
that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is
also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity)

summary for PTGDR Gene:
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. DP receptors (DP1-2) are coupled to Galphas.
They are expressed in the small intestine, lung, stomach and uterus. Activation of DP1 results in inhibition
of platelet activation, vasodilation, and they are involved in sleep regulation. DP2 activation leads to
immune cell activation.

Gene Wiki entry for PTGDR (Prostaglandin D2 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTGDR gene promoter:
         GR   Egr-3   AML1a   Nkx2-5   MIF-1   HEN1   Egr-2   c-Rel   IRF-7A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PTGDR promoter sequence
   Search SABiosciences Chromatin IP Primers for PTGDR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTGDR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

PTGDR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTGDR gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P052734:  view genomic region     (about GC identifiers)

Start:
52,734,431 bp from pter      End:
52,743,442 bp from pter
Size:
9,012 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258 (See protein sequence)
Recommended Name: Prostaglandin D2 receptor  
Size: 359 amino acids; 40271 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q13250 Q13251 Q1ZZ52

Explore the universe of human proteins at neXtProt for PTGDR: NX_Q13258

Explore proteomics data for PTGDR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13258

  • PTGDR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTGDR Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000944.1  NP_001268398.1  

    ENSEMBL proteins: 
     ENSP00000303424   ENSP00000452408  
    Reactome Protein details: Q13258
    Human Recombinant Protein Products for PTGDR: 
    EMD Millipore Purified and/or Recombinant PTGDR Protein
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    OriGene Protein Over-expression Lysate for PTGDR
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    OriGene Custom Protein Services for PTGDR
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    Novus Biologicals PTGDR Protein
    Novus Biologicals PTGDR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS7642548

    PTGDR for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTGR: GPCR / Class A : Prostanoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: DP1 receptor 
    Prostanoid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008365 Prostanoid_rcpt
     IPR000376 Pglndn_D_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q13258

    ProtoNet protein and cluster: Q13258

    1 Blocks protein domain: IPB000376 Prostaglandin D receptor signature

    UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
    Similarity: Belongs to the G-protein coupled receptor 1 family


    PTGDR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PD2R_HUMAN, Q13258
    Function: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins
    that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is
    also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001785prostaglandin J receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004956prostaglandin D receptor activity NAS7642548
    GO:0005515protein binding IPI--
         
    PTGDR for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PTGDR:
     Decreased Wnt reporter activit  Increased cell number in G1, a  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptgdr):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  respiratory system 

    PTGDR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTGDR: Ptgdrtm1Sna Ptgdrtm1Dgen

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTGDR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTGDR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTGDR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTGDR 

    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-4328 hsa-miR-631 hsa-miR-513a-5p hsa-miR-106a hsa-miR-128 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidPTGDR 3' UTR sequence
    Inhib. RNA
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGDR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTGDR About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Prostanoid ligand receptors
    Prostanoid ligand receptors0.60
    Small Ligand GPCRs0.40
    Eicosanoid ligand-binding receptors0.60
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4Prostacyclin signalling through prostacyclin receptor
    G alpha (s) signalling events0.31
    5Thromboxane A2 receptor signaling
    Thromboxane A2 receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for PTGDR
        GPCRs, Class A Rhodopsin-like
    Prostaglandin Synthesis and Regulation
    Thromboxane A2 receptor signaling
    Small Ligand GPCRs

    5/8        Reactome Pathways for PTGDR (see all 8)
        GPCR downstream signaling
    Eicosanoid ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)

    2 PharmGKB Pathways for PTGDR
        Celecoxib Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for PTGDR):
        Neuroactive ligand-receptor interaction


    PTGDR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTGDR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for PTGDR (Q132583 ENSP000003034244) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADRB2ENSP000003053724STRING: ENSP00000305372
    AVPR2ENSP000003380724STRING: ENSP00000338072
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway NAS7642548
    GO:0030238male sex determination IEA--
    GO:0030431sleep IEA--
    GO:0046085adenosine metabolic process IEA--

    PTGDR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTGDR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PTGDR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IloprostProstacyclin (PGI2) analog[78919-13-8]
    L-798,106 Potent and highly selective EP3 antagonist[244101-02-8]
    U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]
    Prostaglandin E2Major endogenous prostanoid[363-24-6]
    L-161,982 Selective EP4 receptor antagonist[147776-06-5]

    3 HMDB Compounds for PTGDR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Prostaglandin D2prostaglandin d2 (see all 22)41598-07-6--

    1 DrugBank Compound for PTGDR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nedocromil-- 69049-73-6targetunknown8939179 17139284 17016423 11544467

    10/24 IUPHAR Ligands for PTGDR (DP1 receptor) (see all 24)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]PGD2
    AgonistFull agonist7.9 - 9.59579725 16604093
    ZK110841
    AgonistFull agonist9.59579725
    BW 245C
    AgonistFull agonist8.4 - 9.49579725 7642548 10448933
    BWA868C
    AntagonistAntagonist8.6 - 9.39579725 7642548 2924081
    L-644,698
    AgonistFull agonist9 - 9.39579725 10448933
    PGD2
    AgonistFull agonist7.8 - 9.29579725 7642548 16604093 10448933
    PGJ2
    AgonistFull agonist99579725
    [3H]BWA868C
    AntagonistAntagonist8.811082108
    S-5751
    AntagonistAntagonist8.811454901
    SQ-27986
    AgonistFull agonist810772998

    10/15 Novoseek inferred chemical compound relationships for PTGDR gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pgd2 95.2 80 18802357 (4), 12148545 (4), 17207480 (4), 17307163 (4) (see all 48)
    bw245c 94.5 6 11082108 (1), 12494276 (1), 11742277 (1), 16272307 (1) (see all 5)
    13,14-dihydro-15-keto-pgd2 93.2 3 11742277 (1), 16272307 (1)
    ramatroban 92.9 3 15179446 (1), 15298571 (1)
    bwa868c 92.3 1 11082108 (1)
    norbornane 82 1 9357516 (1)
    prostaglandin 71.7 11 7492609 (1), 9758211 (1), 12429577 (1), 15298571 (1) (see all 6)
    thromboxane a2 63 5 7492609 (1), 15179446 (1), 9284401 (1), 17154652 (1)
    thromboxane 59.9 2 12429577 (1), 8661119 (1)
    prostacyclin 57.7 6 1775633 (2), 7492609 (1), 9284401 (1), 9758211 (1)

    Search CenterWatch for drugs/clinical trials and news about PTGDR / PD2R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTGDR gene (2 alternative transcripts): 
    NM_000953.2  NM_001281469.1  

    Unigene Cluster for PTGDR:

    Prostaglandin D2 receptor (DP)
    Hs.306831  [show with all ESTs]
    Unigene Representative Sequence: BC040968
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306051(uc001wzq.3) ENST00000553372
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTGDR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTGDR
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTGDR

    Additional mRNA sequence: 

    AK026202.1 BC040968.1 EF577397.1 U31099.1 

    1 DOTS entry:

    DT.95149520 

    10 AceView cDNA sequences:

    U31099 NM_000953 CD013871 BX498371 AI460323 BQ068035 BC040968 AK026202 
    AW841947 AW841862 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PTGDR    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for PTGDR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTGDR expression in normal human tissues (normalized intensities)      PTGDR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTGTAT
    PTGDR Expression
    About this image


    PTGDR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
             Gonad Somatic Cells Primitive Gonad
     
     Ovary (Reproductive System)
             Gonad Somatic Cells Primitive Gonad
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Gonad (Reproductive System)
             Gonad Somatic Cells Primitive Gonad

    See PTGDR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTGDR

    SOURCE GeneReport for Unigene cluster: Hs.306831

    UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
    Tissue specificity: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles,
    iris, small intestine and platelet membranes

        SABiosciences Expression via Pathway-Focused PCR Arrays including PTGDR: 
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              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTGDR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for PTGDR gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ptgdr1 , 5 prostaglandin D receptor1, 5 78.06(n)1
    74.36(a)1
      14 (22.59 cM)5
    192141  NM_008962.41  NP_032988.31 
     448512355 


    ENSEMBL Gene Tree for PTGDR (if available)
    TreeFam Gene Tree for PTGDR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTGDR gene
    PTGER12  PTGER42  PTGFR2  PTGER32  PTGER22  TBXA2R2  PTGIR2  
    3 SIMAP similar genes for PTGDR using alignment to 2 protein entries:     PD2R_HUMAN (see all proteins):
    PTGER2    PTGIR    PTGER4

    PTGDR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/485 SNPs in PTGDR are shown (see all 485)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995784181,2
    C--33715890(+) TGTGT-/GTCTGC
            
    GTGTG
    1 -- us2k10--------
    rs726824491,2
    C,F--33715892(+) TGTGTG/CTGCGT 1 -- us2k13Minor allele frequency- C:0.40WA NA CSA 5
    rs613650141,2
    C,F--33715895(+) GTCTGT/CGTGTG 1 -- us2k15Minor allele frequency- C:0.22NA WA CSA 9
    rs1474623581,2
    C--33715932(+) TGTGTC/G/TTGTCT 1 -- us2k10--------
    rs780854161,2
    C,F--33715939(+) GTCTGT/CCTGTC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1398248341,2
    C--33715948(+) TCTATA/GGAGGA 1 -- us2k10--------
    rs1914293111,2
    --33715992(+) GGTTAC/TGGGGC 1 -- us2k10--------
    rs1439203461,2
    --33716067(+) GGCTAG/TAGATG 1 -- us2k10--------
    rs1823934401,2
    --33716084(+) AGAGAC/GAGTAG 1 -- us2k10--------
    rs8030121,2
    C,F,A,H--33716118(-) GGCCTT/CGTATA 1 -- us2k118Minor allele frequency- C:0.13NS EA NA WA 1976

    HapMap Linkage Disequilibrium report for PTGDR (52734431 - 52743442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PTGDR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832795CNV Gain17160897
    nsv819552CNV Gain19587683


    Human Gene Mutation Database (HGMD): PTGDR
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604687   
    OMIM disorders: 607277  
    UniProtKB/Swiss-Prot: PD2R_HUMAN, Q13258
  • Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma,
    such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test,
    serum IgE levels, atopy and atopic dermatitis. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry

  • 20/24 diseases for PTGDR (see all 24):    About MalaCards
    smallpox    cowpox    osteomyelitis    eye disease
    rabies    atopy    vaccinia    allergic rhinitis
    eclampsia    rhinitis    asthma    choroiditis
    atopic dermatitis    pre-eclampsia    meningioma    dermatitis
    ovarian cancer    neuroblastoma    hepatitis b    adenoma

    1 disease from the University of Copenhagen DISEASES database for PTGDR:
    Asthma

    PTGDR for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for PTGDR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 47.4 29 15496624 (5), 19748656 (3), 16629782 (3), 12002745 (2) (see all 12)
    inflammation 29.8 4 12148545 (1), 18691063 (1), 16888024 (1)

    Genetic Association Database (GAD): PTGDR
    Human Genome Epidemiology (HuGE) Navigator: PTGDR (26 documents)

    Export disorders for PTGDR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTGDR gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with PTGDR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of prostanoid DP receptor variants in susceptibility to asthma. (PubMed id 15496624)1, 2, 4, 9 Oguma T.... Lilly C.M. (2004)
    2. Molecular cloning and characterization of the human prostanoid DP receptor. (PubMed id 7642548)1, 2, 3, 9 Boie Y.... Abramovitz M. (1995)
    3. Promoter genetic variants of prostanoid DP receptor (PTGDR) gene in patients with asthma. (PubMed id 16629782)1, 4, 9 Sanz C....Lorente F. (2006)
    4. New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes. (PubMed id 12002745)1, 4, 9 Noguchi E....Arinami T. (2002)
    5. Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis. (PubMed id 19748656)1, 4, 9 Philip G....Reiss T.F. (2009)
    6. Prostanoid DP receptor (PTGDR) variants in mothers wi th post-coital associated preterm births: preliminary observations. (PubMed id 19710676)1, 4, 9 Grisaru-Granovsky S....Schimmel M.S. (2010)
    7. PTGDR is not a major candidate gene for asthma and atopy in Chinese children. (PubMed id 19220773)1, 4, 9 Leung T.F....Chan J.C. (2009)
    8. Association of PTGDR gene polymorphisms with asthma in two Caucasian populations. (PubMed id 17538632)1, 4, 9 Zhu G....Pillai S.G. (2007)
    9. The PTGDR gene is not associated with asthma in 3 ethnically diverse populations. (PubMed id 17157653)1, 4, 9 Tsai Y.J.... . (2006)
    10. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5729 HGNC: 9591 AceView: PTGDR Ensembl:ENSG00000168229 euGenes: HUgn5729
    ECgene: PTGDR Kegg: 5729 H-InvDB: PTGDR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTGDR Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/apobec3f/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTGDR gene:
    Search GeneIP for patents involving PTGDR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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