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Aliases for PTER Gene

Aliases for PTER Gene

  • Phosphotriesterase Related 2 3 5
  • Parathion Hydrolase-Related Protein 3 4
  • HPHRP 3 4
  • Resiniferatoxin-Binding, Phosphotriesterase-Related 3
  • EC 3.1.-.- 4
  • RPR-1 3

External Ids for PTER Gene

Previous GeneCards Identifiers for PTER Gene

  • GC10P016461
  • GC10P016629
  • GC10P016482
  • GC10P016518

Summaries for PTER Gene

GeneCards Summary for PTER Gene

PTER (Phosphotriesterase Related) is a Protein Coding gene. Diseases associated with PTER include Chromosome 16P13.3 Duplication Syndrome and Spinocerebellar Ataxia Type 16. GO annotations related to this gene include hydrolase activity, acting on ester bonds and endodeoxyribonuclease activity, producing 5-phosphomonoesters.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTER Gene

Genomics for PTER Gene

Regulatory Elements for PTER Gene

Enhancers for PTER Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PTER on UCSC Golden Path with GeneCards custom track

Promoters for PTER Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PTER on UCSC Golden Path with GeneCards custom track

Genomic Location for PTER Gene

16,436,943 bp from pter
16,513,745 bp from pter
76,803 bases
Plus strand

Genomic View for PTER Gene

Genes around PTER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTER Gene

Proteins for PTER Gene

  • Protein details for PTER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphotriesterase-related protein
    Protein Accession:
    Secondary Accessions:
    • B0YJ77
    • B3KTF5
    • D3DRU0
    • Q9BY46

    Protein attributes for PTER Gene

    349 amino acids
    Molecular mass:
    39018 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTER Gene


neXtProt entry for PTER Gene

Proteomics data for PTER Gene at MOPED

Post-translational modifications for PTER Gene

  • Ubiquitination at Lys 19, Lys 302, and Lys 343
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PTER

No data available for DME Specific Peptides for PTER Gene

Domains & Families for PTER Gene

Protein Domains for PTER Gene

Suggested Antigen Peptide Sequences for PTER Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphotriesterase family.
  • Belongs to the phosphotriesterase family.
genes like me logo Genes that share domains with PTER: view

No data available for Gene Families for PTER Gene

Function for PTER Gene

Molecular function for PTER Gene

GENATLAS Biochemistry:
phosphotriesterase-related gene

Enzyme Numbers (IUBMB) for PTER Gene

Gene Ontology (GO) - Molecular Function for PTER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with PTER: view
genes like me logo Genes that share phenotypes with PTER: view

Animal Model Products

miRNA for PTER Gene

miRTarBase miRNAs that target PTER

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTER Gene

Localization for PTER Gene

Subcellular locations from

Jensen Localization Image for PTER Gene COMPARTMENTS Subcellular localization image for PTER gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PTER Gene

Pathways & Interactions for PTER Gene

SuperPathways for PTER Gene

No Data Available

Interacting Proteins for PTER Gene

Gene Ontology (GO) - Biological Process for PTER Gene


No data available for Pathways by source and SIGNOR curated interactions for PTER Gene

Drugs & Compounds for PTER Gene

No Compound Related Data Available

Transcripts for PTER Gene

Unigene Clusters for PTER Gene

Phosphotriesterase related:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTER Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP7: - - -
SP9: -

Relevant External Links for PTER Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTER Gene

mRNA expression in normal human tissues for PTER Gene

mRNA differential expression in normal tissues according to GTEx for PTER Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Frontal Cortex (BA9) (x5.4), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for PTER Gene

This gene is overexpressed in Kidney (10.3) and Skin (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PTER Gene

SOURCE GeneReport for Unigene cluster for PTER Gene Hs.745101

genes like me logo Genes that share expression patterns with PTER: view

Protein tissue co-expression partners for PTER Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PTER Gene

Orthologs for PTER Gene

This gene was present in the common ancestor of animals.

Orthologs for PTER Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PTER 35
  • 85.67 (n)
  • 87.97 (a)
  • 88 (a)
(Canis familiaris)
Mammalia PTER 35
  • 86.72 (n)
  • 89.11 (a)
  • 89 (a)
(Mus musculus)
Mammalia Pter 35
  • 84.53 (n)
  • 87.68 (a)
Pter 16
Pter 36
  • 88 (a)
(Pan troglodytes)
Mammalia PTER 35
  • 98.76 (n)
  • 98.57 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pter 35
  • 83.09 (n)
  • 87.11 (a)
(Monodelphis domestica)
Mammalia PTER 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia PTER 36
  • 81 (a)
(Gallus gallus)
Aves PTER 35
  • 71.82 (n)
  • 73.64 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia PTER 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pter 35
  • 70.96 (n)
  • 75.07 (a)
Str.4983 35
African clawed frog
(Xenopus laevis)
Amphibia pter-prov 35
(Danio rerio)
Actinopterygii Dr.22743 35
pter 35
  • 66.38 (n)
  • 69.34 (a)
pter 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18473 37
  • 43 (a)
CG18473 35
  • 51.91 (n)
  • 46.33 (a)
CG18473 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011061 35
  • 51.07 (n)
  • 45.91 (a)
Species with no ortholog for PTER:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTER Gene

Gene Tree for PTER (if available)
Gene Tree for PTER (if available)

Paralogs for PTER Gene

No data available for Paralogs for PTER Gene

Variants for PTER Gene

Sequence variations from dbSNP and Humsavar for PTER Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs36023740 - 16,484,674(-) TGTTT(C/T)CCACC intron-variant, reference, missense
rs1489492 -- 16,511,393(+) GAGGG(G/T)TTGCC utr-variant-3-prime
rs1532104 -- 16,435,107(-) CTTAG(A/G)CAAGC upstream-variant-2KB
rs1571769 -- 16,479,900(-) GGGAA(C/G)GCATC intron-variant
rs1571770 -- 16,479,821(-) GGCCC(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PTER Gene

Variant ID Type Subtype PubMed ID
nsv894905 CNV Loss 21882294
nsv894906 CNV Loss 21882294
nsv515521 CNV Loss 19592680
nsv466757 CNV Loss 19166990
nsv894907 CNV Gain 21882294
esv269641 CNV Insertion 20981092

Variation tolerance for PTER Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PTER Gene

Disorders for PTER Gene

MalaCards: The human disease database

(23) MalaCards diseases for PTER Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 16p13.3 duplication syndrome
  • 16p13.3 microduplication syndrome
spinocerebellar ataxia type 16
nodular tenosynovitis
  • benign synovioma
bartholin's gland benign neoplasm
  • bartholin gland neoplasm
chromosome 18p deletion syndrome
  • 18p- syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PTER in MalaCards View complete list of genes associated with diseases

Relevant External Links for PTER

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PTER: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTER Gene

Publications for PTER Gene

  1. Assignment1 of phosphotriesterase-related gene (PTER) to human chromosome band 10p12 by in situ hybridization. (PMID: 9925913) Alimova-Kost M.V. … Ninkina N.N. (Cytogenet. Cell Genet. 1998) 2 3 23 67
  2. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. (PMID: 19151714) Meyre D. … Froguel P. (Nat. Genet. 2009) 3 23
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PTER Gene

Sources for PTER Gene