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Aliases for PTENP1 Gene

Subcategory (RNA class) for PTENP1 Gene


Aliases for PTENP1 Gene

  • Phosphatase And Tensin Homolog Pseudogene 1 2 3 5
  • Phosphatase And Tensin Homolog Pseudogene 1 (Functional) 2 3
  • Phosphatase And Tensin Homolog (Mutated In Multiple Advanced Cancers 1), Pseudogene 1 3
  • PTEN/MMAC1 Pseudogene 3
  • PTEN-Rs 3
  • PTENpg1 3
  • PsiPTEN 3
  • PTEN2 3
  • PTH2 3

External Ids for PTENP1 Gene

ORGUL Members for PTENP1 Gene

Previous GeneCards Identifiers for PTENP1 Gene

  • GC09M033987
  • GC09M033844

Summaries for PTENP1 Gene

Entrez Gene Summary for PTENP1 Gene

  • The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Apr 2013]

GeneCards Summary for PTENP1 Gene

PTENP1 (Phosphatase And Tensin Homolog Pseudogene 1) is a Pseudogene, and is affiliated with the lncRNA class.

Gene Wiki entry for PTENP1 Gene

fRNAdb sequence ontologies for PTENP1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for PTENP1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for PTENP1 Gene

Genomics for PTENP1 Gene

Regulatory Elements for PTENP1 Gene

Enhancers for PTENP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F033442 1.5 FANTOM5 ENCODE 5.7 +232.1 232108 6.2 PKNOX1 MLX ARID4B SIN3A YY1 ZNF766 FOS ZNF263 NFYC JUNB AQP7 AQP3 NOL6 PTENP1 NFX1 BAG1 SMU1 PIR43065
GH09F033452 1.2 Ensembl ENCODE 5.3 +223.8 223811 2.6 ELF3 HDGF MLX ZFP64 ARID4B RAD21 ZNF48 RARA ZNF335 GLIS2 AQP3 NOL6 ANKRD18B CYP4F26P PTENP1 GC09P033453 MIR6851
GH09F033455 1.1 Ensembl ENCODE 5.3 +219.6 219590 4.1 BCOR JUN FOSL1 GATA3 CTBP1 ELK1 POLR2A EED RCOR1 ETV6 AQP7 NOL6 AQP3 LOC105376020 BAG1 CHMP5 SUGT1P1 PTENP1 GC09P033453 MIR6851
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PTENP1 on UCSC Golden Path with GeneCards custom track

Promoters for PTENP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001908415 498 1599 SIN3A YY1 ZNF335 GLIS2 ZNF280D YY2 CEBPB REST GLIS1 ZNF341

Genomic Location for PTENP1 Gene

33,673,504 bp from pter
33,677,499 bp from pter
3,996 bases
Minus strand

Genomic View for PTENP1 Gene

Genes around PTENP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTENP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTENP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTENP1 Gene

ORGUL Member Location for PTENP1 Gene

ORGUL Member Location for PTENP1 gene

Proteins for PTENP1 Gene

Post-translational modifications for PTENP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PTENP1 Gene

Domains & Families for PTENP1 Gene

Gene Families for PTENP1 Gene

Suggested Antigen Peptide Sequences for PTENP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTENP1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for PTENP1 Gene

Function for PTENP1 Gene

Molecular function for PTENP1 Gene

GENATLAS Biochemistry:
phosphatase and tensin homolog 2,pseudogene 1,playing a role in small cell lung cancer tumorigenesis (see TSG9A)

Animal Model Products

miRNA for PTENP1 Gene

miRTarBase miRNAs that target PTENP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTENP1 Gene

Localization for PTENP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PTENP1 Gene

Pathways & Interactions for PTENP1 Gene

SuperPathways for PTENP1 Gene

No Data Available

Interacting Proteins for PTENP1 Gene

Gene Ontology (GO) - Biological Process for PTENP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PTENP1 Gene

Transcripts for PTENP1 Gene

fRNAdb Secondary structures for PTENP1 Gene

  • FR279969
  • FR272101

mRNA/cDNA for PTENP1 Gene

Unigene Clusters for PTENP1 Gene

Phosphatase and tensin homolog pseudogene 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTENP1 Gene

No ASD Table

Relevant External Links for PTENP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTENP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTENP1 Gene

mRNA differential expression in normal tissues according to GTEx for PTENP1 Gene

This gene is overexpressed in Whole Blood (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of PTENP1 Gene:


SOURCE GeneReport for Unigene cluster for PTENP1 Gene:

genes like me logo Genes that share expression patterns with PTENP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PTENP1 Gene

Orthologs for PTENP1 Gene

Evolution for PTENP1 Gene

Gene Tree for PTENP1 (if available)
Gene Tree for PTENP1 (if available)

No data available for Orthologs for PTENP1 Gene

Paralogs for PTENP1 Gene

(4) SIMAP similar genes for PTENP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PTENP1: view

No data available for Paralogs for PTENP1 Gene

Variants for PTENP1 Gene

Sequence variations from dbSNP and Humsavar for PTENP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10671396 -- 33,678,709(+) TTTTT(-/T/TTT)TTTTG intron-variant, upstream-variant-2KB
rs10758220 -- 33,678,487(+) TCCAC(G/T)GGCAG intron-variant, upstream-variant-2KB
rs10814025 -- 33,674,779(+) GCTTT(A/T)AAAAA nc-transcript-variant
rs10814026 -- 33,674,791(+) ATGCG(A/C)AAACA nc-transcript-variant
rs10814027 -- 33,677,602(+) GTCTT(C/T)TAATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PTENP1 Gene

Variant ID Type Subtype PubMed ID
nsv968605 CNV duplication 23825009
nsv614150 CNV gain 21841781
nsv518977 CNV gain 19592680
nsv471653 CNV gain 15918152
nsv1125318 OTHER inversion 24896259

Relevant External Links for PTENP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PTENP1 Gene

Disorders for PTENP1 Gene

Relevant External Links for PTENP1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PTENP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTENP1 Gene

Publications for PTENP1 Gene

  1. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21. (PMID: 9620558) Dahia P.L. … Eng C. (Oncogene 1998) 2 3 22 64
  2. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. (PMID: 20577206) Poliseno L. … Pandolfi P.P. (Nature 2010) 2 3 64
  3. Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN. (PMID: 10208437) Fujii G.H. … Bolen J.B. (Oncogene 1999) 3 22 64
  4. Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. (PMID: 9467947) Kim S.K. … Mao L. (Oncogene 1998) 3 22 64
  5. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. (PMID: 9393738) Teng D.H. … Steck P.A. (Cancer Res. 1997) 2 3 64

Products for PTENP1 Gene

Sources for PTENP1 Gene

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