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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PTEN Gene

protein-coding   GIFtS: 72
GCID: GC10P089613

Phosphatase And Tensin Homolog


(Previous symbols: BZS, MHAM)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatase And Tensin Homolog1 2 3     DEC2
Mutated In Multiple Advanced Cancers 11 2 3     PTEN12
MMAC12 3 5     MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 102
BZS1 2     Phosphatase And Tensin-Like Protein2
MHAM1 2     Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And
Dual-Specificity Protein Phosphatase PTEN2
TEP12 3     Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And
Dual-Specificity Protein Phosphatase PTEN2
GLM22 5     EC 3.1.3.163
10q23del2     EC 3.1.3.483
CWS12     EC 3.1.3.673

External Ids:    HGNC: 95881   Entrez Gene: 57282   Ensembl: ENSG000001718627   OMIM: 6017285   UniProtKB: P604843   

Export aliases for PTEN gene to outside databases

Previous GC identifers: GC10P088504 GC10P088844 GC10P089754 GC10P089287 GC10P083258


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PTEN Gene:
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The
protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like
domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.
Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide
substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and
functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. (provided by RefSeq, Jul
2008)

GeneCards Summary for PTEN Gene: 
PTEN (phosphatase and tensin homolog) is a protein-coding gene. Diseases associated with PTEN include endometrial carcinoma, and cowden disease, and among its related super-pathways are Signal transduction AKT signaling and Glioma. GO annotations related to this gene include protein kinase binding and magnesium ion binding. An important paralog of this gene is DNAJC6.

UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484
Function: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine-
and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3
position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol
3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate
preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity
is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by
dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The
unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated
focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion
formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process
of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic
development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in
adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic
nonubiquitinated form induces less tumor suppressive ability

Gene Wiki entry for PTEN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PTEN gene promoter:
         ATF-2   Lmo2   Nkx2-5   CREB   PPAR-gamma1   deltaCREB   STAT3   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPTEN promoter sequence
   Search SABiosciences Chromatin IP Primers for PTEN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTEN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23

PTEN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PTEN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P089613:  view genomic region     (about GC identifiers)

Start:
89,622,870 bp from pter      End:
89,731,687 bp from pter
Size:
108,818 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484 (See protein sequence)
Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase
PTEN  
Size: 403 amino acids; 47166 Da
Cofactor: Magnesium
Subunit: Monomer. The unphosphorylated form interacts with the second PDZ domain of AIP1 and with DLG1 and MAST2
in vitro. Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5. Interaction with
MAGI2 increases protein stability. Interacts with NEDD4. Interacts with NDFIP1 and NDFIP2; in the presence of
NEDD4 or ITCH, this interaction promotes PTEN ubiquitination. Interacts (via C2 domain) with FRK. Interacts with
USP7; the interaction is direct. Interacts with ROCK1 (By similarity). Interacts with XIAP/BIRC4
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Note=Monoubiquitinated form is nuclear.
Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes
its nuclear localization
2 PDB 3D structures from and Proteopedia for PTEN:
1D5R (3D)        2KYL (3D)    
Secondary accessions: B2R904 O00633 O02679 Q6ICT7

Explore the universe of human proteins at neXtProt for PTEN: NX_P60484

Explore proteomics data for PTEN at MOPED 

Post-translational modifications:

  • UniProtKB: Constitutively phosphorylated by CK2 under normal conditions. Phosphorylated in vitro by MAST1, MAST2 and MAST3.
    Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote
    PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation
    probably by inhibiting its binding to NEDD4. Phosphorylation by ROCK1 is essential for its stability and
    activity. Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome
  • UniProtKB: Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading
    to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to
    modulate PTEN compartmentalization. Ubiquitinated by XIAP/BIRC4
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60484

  • PTEN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PTEN Protein Expression
    REFSEQ proteins: NP_000305.3  
    ENSEMBL proteins: 
     ENSP00000361021  
    Reactome Protein details: P60484
    Human Recombinant Protein Products for PTEN: 
    EMD Millipore Purified and/or Recombinant PTEN Protein
    R&D Systems Recombinant & Natural Proteins for PTEN
    Enzo Life Sciences proteins for PTEN
    OriGene Purified Proteins for PTEN
    OriGene Protein Over-expression Lysate for PTEN
    OriGene MassSpec for PTEN 
    OriGene Custom Protein Services for PTEN
    GenScript Custom Purified and Recombinant Proteins Services for PTEN
    Novus Biologicals PTEN Proteins
    Novus Biologicals PTEN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PTEN
    Cloud-Clone Corp. Proteins for PTEN 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17218261
    GO:0005737cytoplasm TAS9367992
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA10760291
    GO:0009898internal side of plasma membrane IDA10940933

    PTEN for ontologies           About GeneDecksing



    PTEN Antibody Products: 
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    Abcam antibodies for PTEN
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    Search LSBio for Antibodies for PTEN 

    Assay Products for PTEN: 
    EMD Millipore Kits and Assays for the Analysis of PTEN
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    Browse R&D Systems for biochemical assays
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for PTEN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PTEN 
    Cloud-Clone Corp. CLIAs for PTEN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

    5/6 InterPro protein domains (see all 6):
     IPR014019 Phosphatase_tensin-typ
     IPR016130 Tyr_Pase_AS
     IPR017361 Bifunc_PIno_P3_Pase/Pase_PTEN
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry P60484

    ProtoNet protein and cluster: P60484

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484
    Domain: The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is
    important for its tumor suppressor function
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phosphatase tensin-type domain


    PTEN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PTEN_HUMAN, P60484
    Function: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine-
    and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3
    position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol
    3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate
    preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity
    is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by
    dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The
    unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated
    focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion
    formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process
    of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic
    development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in
    adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic
    nonubiquitinated form induces less tumor suppressive ability
    Catalytic activity: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate +
    phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Induction: Down-regulated by TGFB1

         Genatlas biochemistry entry for PTEN:
    phosphatase and tensin homolog,antagonizing signal transduction downstream of PI-3 kinase by dephosphorylating
    phosphatidylinositol-phosphate (PtdInsP),expressed in normal colon,tumor suppressor gene,modulating cell cycle
    progression and cell survival,negative regulator of cell interactions with the extracellular matrix,mutated in
    multiple advanced cancers (prostate and colorectal carcinoma,primary glioblastoma,renal cell carcinoma,breast and
    brain cancer,small cell lung cancer,squamous cell carcinoma of head and neck,sporadic follicular thyroid
    tumor,Cowden syndrome,melanoma and Bannayan Zonana syndrome,endometrial atypical hyperplasia,high grade
    astrocytoma,lymphoid neoplasms,laryngeal tumors),inversely correlated with AKF1

         Enzyme Numbers (IUBMB): EC 3.1.3.671 EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004438phosphatidylinositol-3-phosphatase activity IDA9811831
    GO:0004721phosphoprotein phosphatase activity IDA--
    GO:0004722protein serine/threonine phosphatase activity IDA9256433
    GO:0004725protein tyrosine phosphatase activity IDA9256433
         
    PTEN for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for PTEN:
     Decreased focal adhesion (FA)   Decreased sensitivity to pacli  Increased Akt phosphorylation   Increased apoptosis 
     Increased cell death HMECs cel  Increased cell death in breast  Increased resistance to Trastu  Synthetic lethal with c-Myc af 

         15/27 MGI mutant phenotypes (inferred from 17 alleles(MGI details for Pten) (see all 27):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    PTEN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PTEN: Ptentm1.2Mwst Ptentm1.1Gle Ptentm1.1Hwu Ptentm1.1Mro Ptentm2.1Gle Ptentm2Hwu
                                                         Ptentm1Ppp Ptentm1Rps Ptentm1Mak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PTEN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PTEN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PTEN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PTEN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PTEN:
    hsa-mir-21 (MIRT001190), hsa-mir-216a (MIRT000534), hsa-mir-217 (MIRT000533), hsa-mir-19b (MIRT003371), hsa-mir-18a (MIRT003370), hsa-mir-141 (MIRT003281), hsa-mir-19a (MIRT002958), hsa-mir-214 (MIRT000799), hsa-mir-20a (MIRT003369), hsa-mir-222 (MIRT005586), hsa-mir-221 (MIRT005585), hsa-mir-26a (MIRT001095), hsa-mir-494 (MIRT001209), hsa-mir-106b (MIRT005865), hsa-mir-17 (MIRT000499)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTEN
    8/128 QIAGEN miScript miRNA Assays for microRNAs that regulate PTEN (see all 128):
    hsa-miR-579 hsa-miR-3938 hsa-miR-106a hsa-miR-519a hsa-miR-642b hsa-miR-200b hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidPTEN 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PTEN About   (see all 65)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Glioma
    Glioma0.51
    Prostate cancer0.39
    Melanoma0.43
    Signaling Pathways in Glioblastoma0.36
    3Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    4Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    5Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation0.51
    mTOR signaling pathway0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for PTEN (see all 8)
        Development EGFR signaling via PIP3
    Immune response BCR pathway
    Signal transduction PTEN pathway
    Cytoskeleton remodeling FAK signaling
    Transcription Receptor-mediated HIF regulation

    2 R&D Systems Pathways for PTEN
        Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PTEN (see all 19)
        Sertoli-Sertoli Cell Junction Dynamics
    IL-4 Pathway
    Molecular Mechanisms of Cancer
    Glioblastoma Multiforme
    PI3K Signaling in B-Lymphocyte

    3 Cell Signaling Technology (CST) Pathways for PTEN
        Phosphatases
    PI3K / Akt Signaling
    Glucose / Energy Metabolism

    5/8 GeneGo (Thomson Reuters) Pathways for PTEN (see all 8)
        Signal transduction AKT signaling
    Signal transduction PTEN pathway
    Development IGF-1 receptor signaling
    Immune response BCR pathway
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/23 BioSystems Pathways for PTEN (see all 23)
        Focal Adhesion
    Senescence and Autophagy
    DNA damage response (only ATM dependent)
    Insulin Signaling
    Integrated Breast Cancer Pathway

    2 Sino Biological Pathways for PTEN 
        p53 Pathway
    VEGF Signaling

    5/41        Reactome Pathways for PTEN (see all 41)
        Signaling by EGFR in Cancer
    Inositol phosphate metabolism
    Negative regulation of the PI3K/AKT network
    Downstream signal transduction
    Signal Transduction


    5/15         Kegg Pathways  (Kegg details for PTEN) (see all 15):
        Inositol phosphate metabolism
    Phosphatidylinositol signaling system
    p53 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway


    PTEN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PTEN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/208 Interacting proteins for PTEN (P604841, 2, 3 ENSP000003610214) via UniProtKB, MINT, STRING, and/or I2D (see all 208)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147452, 3, ENSP000002626134MINT-2832476 MINT-2832448 MINT-2832508 I2D: score=2 STRING: ENSP00000262613
    BMI1P352262, 3, ENSP000003658514MINT-8291498 MINT-8291473 MINT-8291483 I2D: score=1 STRING: ENSP00000365851
    CAV1Q031352, 3, ENSP000003391914MINT-6793865 MINT-6793823 I2D: score=5 STRING: ENSP00000339191
    HBA1P699052, 3, ENSP000003224214MINT-63919 I2D: score=4 STRING: ENSP00000322421
    HBA2P699052, 3, ENSP000002515954MINT-63919 I2D: score=4 STRING: ENSP00000251595
    About this table

    Gene Ontology (GO): 5/80 biological process terms (GO ID links to tree view) (see all 80):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS10918569
    GO:0001525angiogenesis IEA--
    GO:0001933negative regulation of protein phosphorylation IDA--
    GO:0002902regulation of B cell apoptotic process IEA--
    GO:0006470protein dephosphorylation TAS9367992

    PTEN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PTEN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PTEN

    10/383 HMDB Compounds for PTEN (see all 383)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    MagnesiumMagnesium (see all 2)7439-95-4--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----

    10/100 Novoseek inferred chemical compound relationships for PTEN gene (see all 100)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol-3,4,5-trisphosphate 84.8 43 11463863 (5), 10377431 (2), 15465874 (1), 17703603 (1) (see all 38)
    phosphatidylinositol 83.4 204 16371363 (3), 12360479 (3), 12743124 (3), 11477064 (3) (see all 99)
    phosphoinositide 80.1 104 11463863 (3), 10555148 (3), 11716755 (3), 12878591 (2) (see all 81)
    ly294002 77.3 33 18483299 (2), 12839945 (2), 15986432 (1), 19618119 (1) (see all 29)
    rapamycin 77.2 94 19115995 (6), 12939469 (3), 18431376 (2), 18332865 (2) (see all 45)
    wortmannin 63.5 22 11230180 (2), 12360479 (2), 11932928 (2), 10400703 (1) (see all 15)
    panitumumab 62.6 2 19806185 (2)
    erlotinib 60.8 9 17363510 (3), 19562712 (2), 16282176 (1), 20462843 (1) (see all 6)
    trastuzumab 58.9 54 15324695 (7), 16404430 (6), 16550004 (4), 19016009 (4) (see all 17)
    tyrosine 56.9 115 12869565 (5), 9187108 (4), 11219390 (3), 19723324 (3) (see all 67)

    Search CenterWatch for drugs/clinical trials and news about PTEN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PTEN gene: 
    NM_000314.4  

    Unigene Cluster for PTEN:

    Phosphatase and tensin homolog
    Hs.500466  [show with all ESTs]
    Unigene Representative Sequence: NM_000314
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371953(uc001kfb.3 uc021pvw.1) ENST00000487939 ENST00000462694
    ENST00000498703 ENST00000472832
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTEN
    8/128 QIAGEN miScript miRNA Assays for microRNAs that regulate PTEN (see all 128):
    hsa-miR-579 hsa-miR-3938 hsa-miR-106a hsa-miR-519a hsa-miR-642b hsa-miR-200b hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidPTEN 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTEN
    Clone
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    OriGene clones in human, mouse for PTEN (see all 7)
    OriGene ORF clones in mouse, rat for PTEN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PTEN (NM_000314)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTEN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTEN
    Sirion Biotech Customized lentivirus for stable overexpression of PTEN 
                         Customized lentivirus expression plasmids for stable overexpression of PTEN 
    Primer
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    OriGene qPCR primer pairs and template standards for PTEN
    OriGene qSTAR qPCR primer pairs in human, mouse for PTEN
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTEN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTEN

    Additional mRNA sequence: 

    AK024986.1 AK313581.1 BC005821.2 CR450306.1 JF268690.1 U92436.1 U93051.1 U96180.1 

    24/25 DOTS entries (see all 25):

    DT.418393  DT.446589  DT.121248879  DT.99934702  DT.100810879  DT.91643032  DT.100780088  DT.207118 
    DT.97819946  DT.97842009  DT.91926931  DT.121248850  DT.91798136  DT.92425517  DT.100768844  DT.121248739 
    DT.121248890  DT.95090682  DT.121248723  DT.207117  DT.308329  DT.91647834  DT.91824869  DT.95271343 

    24/355 AceView cDNA sequences (see all 355):

    AW197432 CR450306 AI419575 AA603466 BX483075 Z39686 Z40810 BU676102 
    AA424696 CA943539 AA766137 AI869053 AI651850 BM129829 BQ006553 BX348605 
    CK819731 BG619024 BQ001795 BM717806 BQ224808 AA370757 BM129320 BM719003 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PTEN expression in normal human tissues (normalized intensities)      PTEN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PTEN Expression
    About this image


    PTEN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Septum   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   
     
     Gonad
             Primary Oocyte Primordial Follicle
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Early Retinal Progenitor Cells Retinal Neuroblastic Layer
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primordial Follicle

    See PTEN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PTEN

    SOURCE GeneReport for Unigene cluster: Hs.500466

    UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484
    Tissue specificity: Expressed at a relatively high level in all adult tissues, including heart, brain, placenta,
    lung, liver, muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including PTEN (see all 23): 
              Parkinson's Disease in human mouse rat
              Tight Junctions in human mouse rat
              Wound Healing in human mouse rat
              Autophagy in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTEN
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTEN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PTEN gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pten1 , 5 phosphatase and tensin homolog1, 5 96.2(n)1
    99.75(a)1
      19 (28.14 cM)5
    192111  NM_008960.21  NP_032986.11 
     327574975 
    chicken
    (Gallus gallus)
    Aves PTEN1 phosphatase and tensin homolog 91.29(n)
    95.52(a)
      423675  XM_421555.3  XP_421555.2 
    lizard
    (Anolis carolinensis)
    Reptilia PTEN6
    Uncharacterized protein
    94(a)
    1 ↔ 1
    GL343246.1(921793-993316)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5612 Xenopus laevis protein/lipid phosphatase Pten (Pten) more 84.75(n)    AF144732.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pten2 Danio rerio phosphatase and tensin-like protein B short more 78.62(n)    AY398671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pten1 , 3 insulin receptor signaling pathway
    actin binding3
    CG5671-PA1
    44(a)3
    54.05(n)1
    49.84(a)1
      439911  NM_058076.31  NP_477424.11 
    worm
    (Caenorhabditis elegans)
    Secernentea daf-183   -- 43(a)   IV(420426-425148)   --
    rice
    (Oryza sativa)
    Liliopsida AK121747.12   -- 73.81(n)    AK121747.1 


    ENSEMBL Gene Tree for PTEN (if available)
    TreeFam Gene Tree for PTEN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PTEN gene
    DNAJC62  TNS12  TPTE2  TENC12  GAK2  TPTE22  TNS42  TNS32  
    8 SIMAP similar genes for PTEN using alignment to 5 protein entries:     PTEN_HUMAN (see all proteins):
    PTENP1    PTEN2    TENC1    TPTE2    TNS3    TNS1
    GAK    TPTE

    PTEN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2032 SNPs in PTEN are shown (see all 2032)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0115894
    Multiple cancers4--see VAR_0115892 V L mis40--------
    VAR_0262754
    Cowden syndrome 1 (CWS1)4--see VAR_0262752 D G mis40--------
    VAR_0115884
    Multiple cancers4--see VAR_0115882 V L mis40--------
    VAR_0326354
    One patient with clinical findings suggesting hamartoma tumor syndrome4--see VAR_0326352 G V mis40--------
    VAR_0087394
    Cowden syndrome 1 (CWS1)4--see VAR_0087392 G E mis40--------
    VAR_0115874
    Cowden syndrome 1 (CWS1)4--see VAR_0115872 R G mis40--------
    VAR_0262594
    Glioblastoma4--see VAR_0262592 A P mis40--------
    VAR_0074624
    Cowden syndrome 1 (CWS1)4--see VAR_0074622 Y H mis40--------
    VAR_0074604
    Glioma4--see VAR_0074602 L W mis40--------
    VAR_0078084
    Cowden syndrome 1 (CWS1)4--see VAR_0078082 C Y mis40--------

    HapMap Linkage Disequilibrium report for PTEN (89622870 - 89731687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PTEN:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678342CNV Deletion23128226
    esv2530664CNV Deletion19546169
    nsv820703CNV Deletion20802225
    esv25064CNV Gain19812545
    esv275087CNV Gain+Loss21479260


    Human Gene Mutation Database (HGMD): PTEN
    5/45 SABiosciences Cancer Mutation PCR Assays for PTEN (see all 45):
    Cosmic IdAA Change
    4956p.Y76fs*1
    39513p.R378fs*>25
    5847p.K164fs*3
    5092p.G129R
    5216p.R130L
    5/19 SABiosciences Cancer Mutation PCR Arrays containing PTEN (see all 19):
    Receptor Tyrosine Kinase (RTK) (Panel II)
    Cancer Comprehensive Panel 384HT
    KIT Pathway
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing PTEN:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing PTEN
    DNA2.0 Custom Variant and Variant Library Synthesis for PTEN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601728   
    OMIM disorders: 158350  153480  607174  613028  605309  276950  176807  188470  155600  608089  275355  
    UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484
  • Cowden syndrome 1 (CWS1) [MIM:158350]: An autosomal dominant hamartomatous polyposis syndrome with
    age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of
    ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair
    follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several
    types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon
    cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but
    most commonly in the skin, gastrointestinal tract, breast and thyroid. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Lhermitte-Duclos disease (LDD) [MIM:158350]: A rare disease characterized by the occurrence of a slowly
    enlarging mass within the cerebellar cortex corresponding histologically to a cerebellar hamartoma. It manifests,
    most commonly in the third and fourth decades of life, with increased intracranial pressure, headache, nausea,
    cerebellar dysfunction, occlusive hydrocephalus, ataxia, visual disturbances and other cranial nerve palsies.
    Various associated abnormalities may be present such as megalencephaly, microgyria, hydromyelia, polydactyly,
    partial gigantism, macroglossia. LDD is part of the PTEN hamartoma tumor syndromes spectrum that also includes
    Cowden syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Bannayan-Riley-Ruvalcaba syndrome (BRRS) [MIM:153480]: A rare hamartomatous disorder characterized by
    macrocephaly and multiple hemangiomas as well as subcutaneous and visceral lipomas. It belongs to the family of
    hamartomatous polyposis syndromes that includes Peutz Jeghers syndrome, juvenile polyposis, and Cowden syndrome.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting
    the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Endometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus.
    Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other
    fluids. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry
  • Note=PTEN mutations are found in a subset of patients with Proteus syndrome, a genetically heterogeneous
    condition. The molecular diagnosis of PTEN mutation positive cases classifies Proteus syndrome patients as part
    of the PTEN hamartoma syndrome spectrum. As such, patients surviving the early years of Proteus syndrome are
    likely at a greater risk of developing malignancies
  • Glioma 2 (GLM2) [MIM:613028]: Gliomas are benign or malignant central nervous system neoplasms derived
    from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes,
    oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • VACTERL association with hydrocephalus (VACTERL-H) [MIM:276950]: VACTERL is an acronym for vertebral
    anomalies, anal atresia, congenital cardiac disease, tracheoesophageal fistula, renal anomalies, radial
    dysplasia, and other limb defects. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate
    cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of
    prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma,
    prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid
    cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility
    is associated with variations affecting the gene represented in this entry
  • Macrocephaly/autism syndrome (MCEPHAS) [MIM:605309]: Patients have autism spectrum disorders and
    macrocephaly, with head circumferences ranging from +2.5 to +8 SD for age and sex (average head circumference
    +4.0 SD). Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23
    deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome,
    Cowden disease and juvenile polyposis syndrome

  • 20/251 diseases for PTEN (see all 251):    About MalaCards
    endometrial carcinoma    cowden disease    bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome
    pten hamartoma tumor syndrome    proteus-like syndrome    juvenile polyposis of infancy    squamous cell carcinoma of the head and neck
    squamous cell carcinoma, head and neck, somatic    macrocephaly/autism syndrome    breast-ovarian cancer, familial, 2    vacterl association with hydrocephalus
    glioma susceptibility 2    proteus syndrome    gliomatosis cerebri    mature t-cell and nk-cell neoplasm
    prostate cancer, somatic    thyroid carcinoma, follicular, somatic    endometrial carcinoma, somatic    vater association with macrocephaly and ventriculomegaly

    17 diseases from the University of Copenhagen DISEASES database for PTEN:
    Cowden disease     Bannayan-Riley-Ruvalcaba syndrome     Malignant glioma     Endometrial cancer
    Prostate cancer     Carcinoma     Proteus syndrome     Breast cancer
    Peutz-Jeghers syndrome     Colorectal cancer     Ovarian cancer     Thyroid cancer
    Melanoma     Lung cancer     Gangliocytoma     Lipomatosis
    Parkinson's disease

    PTEN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for PTEN gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cowden disease 96 261 16007494 (5), 14675182 (4), 11918710 (3), 12620973 (3) (see all 99)
    bannayan-zonana syndrome 89.2 20 10232405 (2), 9241266 (1), 9620558 (1), 11964046 (1) (see all 18)
    glioblastoma 84.1 272 9690672 (9), 9426052 (8), 19190120 (6), 12904991 (6) (see all 99)
    tumors 82.1 2252 9605750 (8), 12684422 (7), 16027168 (6), 11595133 (6) (see all 99)
    endometrial carcinoma 81.3 266 19224164 (8), 12001116 (6), 17009632 (6), 10851265 (5) (see all 96)
    juvenile polyposis syndrome 81 10 19381654 (1), 9399897 (1), 11005140 (1), 9661881 (1) (see all 9)
    proteus syndrome 76.9 28 15372512 (4), 18431376 (2), 17483958 (2), 16704655 (2) (see all 19)
    macrocephaly 76.6 50 17427195 (5), 15805158 (4), 17286265 (3), 19265751 (3) (see all 22)
    cancer 76.4 660 12370746 (6), 15132901 (4), 17341655 (4), 19285250 (4) (see all 99)
    carcinoma endometrioid 75.6 51 18653908 (4), 12405911 (4), 11156411 (4), 15668893 (3) (see all 23)

    GeneTests: PTEN
    GeneReviews: PTEN
    Genetic Association Database (GAD): PTEN
    Human Genome Epidemiology (HuGE) Navigator: PTEN (125 documents)

    Export disorders for PTEN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PTEN gene, integrated from 9 sources (see all 2454):
    (articles sorted by number of sources associating them with PTEN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. (PubMed id 15805158)1, 2, 4, 9 Butler M.G....Eng C. (2005)
    2. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. (PubMed id 9090379)1, 2, 3, 9 Steck P.A.... Tavtigian S.V. (1997)
    3. The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. (PubMed id 9345101)1, 2, 4 Tsou H.C.... Peacocke M. (1997)
    4. TP53 mutations in endometrial cancers: relation to PT EN gene defects. (PubMed id 20169661)1, 4, 9 Janiec-Jankowska A....NajmoA8a U. (2010)
    5. PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations. (PubMed id 16793127)1, 4, 9 Kolasa I.K....Kupryjanczyk J. (2006)
    6. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PubMed id 15951562)1, 2, 9 Valiente M.... Pulido R. (2005)
    7. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. (PubMed id 11707428)1, 2, 9 Vazquez F....Sellers W.R. (2001)
    8. Molecular alterations of EGFR and PTEN in prostate ca ncer: association with high-grade and advanced-stage carcinomas. (PubMed id 20208477)1, 4, 9 de Muga S....Lloreta J. (2010)
    9. Is PTEN loss associated with clinical outcome measures in human prostate cancer? (PubMed id 18854827)1, 4, 9 McCall P....Edwards J. (2008)
    10. No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer. (PubMed id 19673018)1, 4, 9 Phillips L.S....Li L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5728 HGNC: 9588 AceView: PTEN Ensembl:ENSG00000171862 euGenes: HUgn5728
    ECgene: PTEN Kegg: 5728 H-InvDB: PTEN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PTEN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PTEN Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PTEN
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pten/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PTEN gene:
    Search GeneIP for patents involving PTEN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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