 |
 | Services
| |
 |
Aliases &
Descriptions
for PTEN
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| 10q23del 2 | | BZS 2 | | EC 3.1.3.67,EC 3.1.3.16,EC 3.1.3.48 3 | | MGC11227 2 | | MHAM 2 | | MMAC1 1, 2, 3, 5 | | OTTHUMP00000020032 2 | | PTEN1 1, 2 | | TEP1 1, 2, 3 |
| | | Descriptions |
|---|
MMAC1 phosphatase and tensin homolog deleted on chromosome
10 2 | | Mutated in multiple advanced cancers 1 2, 3 | | phosphatase and tensin homolog 2, 3 |
|
| |
Search outside databases for aliases for PTEN genePrevious GC identifers: GC10P088504 GC10P088844 GC10P089754 GC10P089287 |
Summaries
for PTEN(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PTEN:
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high
frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate
3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of
the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine
phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It
negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and
functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by
RefSeq]
UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484Function: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating
tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase,
removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol
3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and
inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 >
PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its
tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating
phosphoinositides and thereby modulating cell cycle progression and cell survival. The
unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates
tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated
cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and
glucose metabolism in adipose tissueGene Wiki entry for PTEN |
Genomic Location
for PTEN
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the PTEN gene 
Entrez Gene cytogenetic band: 10q23.3 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23PTEN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P089613:
(about GC identifiers)
Start:
|
89,613,175 bp from pter |
End:
|
89,718,512 bp from pter |
Size:
|
105,338 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins
for PTEN
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484 (See
protein sequence)Recommended Name: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity
protein phosphatase PTEN Size: 403 amino acids; 47166 Da
Cofactor: Magnesium
Subunit: Monomer. The unphosphorylated form interacts with the second PDZ domain of AIP1 and with
DLG1 and MAST2 in vitro. Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor
with DLG5. Interaction with MAGI2 increases protein stability
Subcellular location: Cytoplasm
PDB structures from  and Proteopedia  :1D5R (3D)
Secondary accessions: O00633 O02679 Q6ICT7Post-translational modifications:
Phosphorylated in vitro by MAST1, MAST2 and MAST3. Phosphorylation results in an inhibited activity
towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_000305.3
ENSEMBL proteins: ENSP00000361021
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for PTEN:  | Invitrogen Antibodies for PTEN |  | Millipore Mono- and Polyclonal Antibodies for the study of PTEN |  | Sigma-Aldrich Antibody Arrays and Antibodies for PTEN |  | R&D Systems Antibodies for PTEN |  | Cell Signaling Technology (CST) Antibodies for PTEN |  | Antibodies from Abcam (PTEN), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (PTEN) |  | Novus Biologicals Antibodies for PTEN |
Assays for PTEN: | Protein
Domains/
Families
for PTEN(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P60484
ProtoNet protein and cluster: P60484 1 Blocks protein family: IPB000340 Dual specificity protein phosphatase
UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484Domain: The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this
binding is important for its tumor suppressor functionSimilarity: Contains 1 C2 tensin-type domainSimilarity: Contains 1 phosphatase tensin-type domain | Gene Function
for PTEN
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Inhib.
RNA: | | Invitrogen RNAi Products for gene knock-down (PTEN) | | | Millipore RNAi Products for the Analysis of PTEN Gene knock-down | | | Abnova Chimera RNAi Products for Gene knock-down (PTEN) |
OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000314
 Applied Biosystems Silencer® siRNAs for PTEN
Sigma-Aldrich siRNA and siRNA Panels for PTEN
Sigma-Aldrich shRNA Panels and shRNA for PTEN
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000314
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000314
untagged cDNA clone in CMV expression vector: NM_000314
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_000314
UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484Function: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating
tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase,
removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol
3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and
inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 >
PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its
tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating
phosphoinositides and thereby modulating cell cycle progression and cell survival. The
unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates
tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated
cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and
glucose metabolism in adipose tissueCatalytic activity: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol
4,5-bisphosphate + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateInduction: Down-regulated by transforming growth factor beta (TGF-beta)Enzyme Number (IUBMB): EC 3.1.3.67,EC Genatlas biochemistry entry for PTEN:phosphatase and tensin homolog,antagonizing signal transduction downstream of PI-3 kinase by
dephosphorylating phosphatidylinositol-phosphate (PtdInsP),expressed in normal colon,tumor
suppressor gene,modulating cell cycle progression and cell survival,negative regulator of cell
interactions with the extracellular matrix,mutated in multiple advanced cancers (prostate and
colorectal carcinoma,primary glioblastoma,renal cell carcinoma,breast and brain cancer,small cell
lung cancer,squamous cell carcinoma of head and neck,sporadic follicular thyroid tumor,Cowden
syndrome,melanoma and Bannayan Zonana syndrome,endometrial atypical hyperplasia,high grade
astrocytoma,lymphoid neoplasms,laryngeal tumors),inversely correlated with AKF115/23 MGI mutant phenotypes (inferred from 13 alleles ) (MGI details for Pten) (see all 23
):
5/13 Gene Ontology (GO) molecular function terms (links to tree view) (see all 13
): About this table | Pathways & Interactions
for PTEN
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/18 Sigma-Aldrich "Your Favorite Gene" Pathways for PTEN (Your Favorite Gene powered by Ingenuity) (see all 18
)
Gene Network CentralTM Interacting Genes and Proteins Network for PTEN
5/224 Interacting proteins for PTEN (ENSP000003610213 P604841, 2) via UniProtKB, MINT, and/or STRING (see all 224
)About this table
5/19 Gene Ontology (GO) biological process terms (links to tree view) (see all 19
): About this table
|
Drugs & Compounds
for PTEN(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PTEN
10/45  Novoseek chemical compound relationships for PTEN gene (see all 45
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphatidylinositol-3,4,5-trisphosphate |
85.17 |
40 |
11463863 (5), 10377431 (2), 15465874 (1), 17703603 (1) (see all 36) |
| phosphatidylinositol |
83.34 |
196 |
16371363 (3), 12360479 (3), 12743124 (3), 11477064 (3) (see all 99) |
| phosphoinositide |
79.20 |
92 |
11463863 (3), 10555148 (3), 11716755 (3), 12878591 (2) (see all 70) |
| wortmannin |
64.74 |
20 |
11230180 (2), 12360479 (2), 11932928 (2), 10400703 (1) (see all 14) |
| tyrosine |
54.56 |
104 |
12869565 (5), 9187108 (4), 11219390 (3), 9072974 (3) (see all 60) |
| lipid |
52.41 |
210 |
15273733 (4), 11230179 (4), 18332865 (4), 10644997 (4) (see all 99) |
| gw501516 |
48.04 |
6 |
18390835 (5), 16061473 (1) |
| threonine |
44.79 |
20 |
15951562 (4), 11875759 (1), 17667591 (1), 12626642 (1) (see all 11) |
| phosphatidylinositol phosphate |
43.87 |
3 |
12857747 (1), 16675164 (1), 18220422 (1) |
| inositol 1,3,4,5,6-pentakisphosphate |
38.32 |
3 |
11418101 (2), 14561749 (1) |
About this table
1 PharmGKB drug compound relationship for PTEN gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| trastuzumab | PD | 15324695 | About this table
|
Transcripts
for PTEN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| Inhib.
RNA: | | Invitrogen RNAi Products for gene knock-down (PTEN) | | | Millipore RNAi Products for the Analysis of PTEN Gene knock-down | | | Abnova Chimera RNAi Products for Gene knock-down (PTEN) |
OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000314
Sigma-Aldrich siRNA and siRNA Panels for PTEN
Sigma-Aldrich shRNA Panels and shRNA for PTEN
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_000314 REFSEQ mRNAs for PTEN gene: NM_000314.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000314
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000314
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000314
untagged cDNA clone in CMV expression vector: NM_000314
Additional cDNA sequence: AK024986.1 AK313581.1 BC005821.2 CR450306.1 CR624542.1 U92436.1 U93051.1 U96180.1 24/25 DOTS entries (see all 25
): DT.418393 DT.446589 DT.121248879 DT.100810879 DT.99934702 DT.91643032 DT.100780088 DT.207118 DT.97819946 DT.91926931 DT.97842009 DT.121248850 DT.207117 DT.91798136 DT.100768844 DT.121248739 DT.121248890 DT.91729580 DT.95090682 DT.95344490 DT.121248723 DT.308329 DT.91647834 DT.91824869 24/355 AceView cDNA sequences (see all 355
):BM719003 BF433618 BU431202 BX375027 AA766137 BQ006553 CK819732 CA943539 CK819731 CK819599 BX479593 BX503269 AA954077 BU676066 BQ224808 BM717806 CR450306 AW197432 CB243436 NM_000314 AI869053 AA857459 AA609756 Z39686
 highest scoring ESTs for PTEN:U92436 AA001098 AA017584 AA527846 AA609756 AA632413 AA635826 AA648435 AA730616 AA742608 Unigene Cluster for PTEN: Phosphatase and tensin homolog Hs.500466 [show with all ESTs]Unigene Representative Sequence: NM_000314
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000371953
|
Expression
for PTEN
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PTEN expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PTEN
1 / 2 / 3 23 probe-sets matching PTEN gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.500466
Expression variation in blood from EXPOLDB for PTEN UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484Tissue specificity: Expressed at a relatively high level in all adult tissues, including heart,
brain, placenta, lung, liver, muscle, kidney and pancreas |
Orthologs
for PTEN
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PTEN gene from 5/15 species (see all 15
)
About this table Species with no ortholog for PTEN
ENSEMBL Gene Tree for PTEN | Paralogs
for PTEN(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PTEN gene
- DNAJC62 TPTE2 GAK2 LOC2201152 TPTE22
|
SNPs/Variants
for PTEN(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PTEN (up to first 250kb)
|
Disorders & Mutations
for PTEN
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601728 UniProtKB/Swiss-Prot: PTEN_HUMAN, P60484
Mutations of PTEN are found in a large number of cancers Defects in PTEN are a cause of Cowden disease (CD) [MIM:158350]; also known as Cowden
syndrome (CS). CD is an autosomal dominant cancer predisposition syndrome associated with elevated
risk for tumors of the breast, thyroid and skin. The predominant phenotype for CD is multiple
hamartoma syndrome, in many organ systems including the breast (70% of CD patients), thyroid
(40-60%), skin, CNS (40%), gastrointestinal tract. Affected individuals are at an increased risk
of both breast and thyroid cancers. Trichilemmomas (benign tumors of the hair follicle
infundibulum), and mucocutaneous papillomatosis (99%) are hallmarks of CD Defects in PTEN are the cause of Lhermitte-Duclos disease (LDD) [MIM:158350]; also known
as cerebelloparenchymal disorder VI. LDD is characterized by dysplastic gangliocytoma of the
cerebellum which often results in cerebellar signs and seizures. LDD and CD seem to be the same
entity, and are considered as hamartoma-neoplasia syndromes Defects in PTEN are a cause of Bannayan-Zonana syndrome (BZS) [MIM:153480]; also known as
Ruvalcaba-Riley-Smith or Bannayan-Riley-Ruvalcaba syndrome (BRRS). In BZS there seems not to be an
increased risk of malignancy. It has a partial clinical overlap with CD. BZS is characterized by
the classic triad of macrocephaly, lipomatosis and pigmented macules of the gland penis Defects in PTEN are a cause of squamous cell carcinoma of the head and neck (HNSCC)
[MIM:275355] Defects in PTEN are a cause of susceptibility to endometrial cancer [MIM:608089] Defects in PTEN are a cause of Proteus syndrome [MIM:176920]. Proteus syndrome is a
hamartomatous disorder characterized by overgrowth of multiple tissues, connective tissue and
epidermal naevi, and vascular malformations. These presentations are usually apparent at birth or
soon after and continue to develop as the patient ages. It is named after the Greek god Proteus
who, legend has it, could change his shape at will to avoid capture. Tumors, mostly benign but
some malignant, have also been reported in Proteus syndrome, generally presenting by the age of 20
years and including papillary adenocarcinoma of the testis, meningioma, and cystadenoma of the
ovaries Defects in PTEN are a cause of oligodendroglioma [MIM:137800]; also called
oligodendroblastoma or familial glioma of brain. Oligodendroglioma is a usually benign neoplasm
derived from and composed of oligodendrogliocytes in varying stages of differentiation. The
majority are seen in adults in the white matter of the brain Defects in PTEN are a cause of VACTERL association with hydrocephalus [MIM:276950]; which
includes also VATER association with hydrocephalus. VACTERL is an acronym for vertebral anomalies,
anal atresia, congenital cardiac disease, tracheoesophageal fistula, renal anomalies, radial
dysplasia, and other limb defects Defects in PTEN are involved in prostate cancer [MIM:176807] Defects in PTEN are a cause of macrocephaly/autism syndrome [MIM:605309]. Patients have
autism spectrum disorders and macrocephaly, with head circumferences ranging from +2.5 to +8 SD
for age and sex (average head circumference +4.0 SD) A microdeletion of chromosome 10q23 involving PTEN and BMPR1A is a cause of chromosome
10q23 deletion syndrome [MIM:612242]. This syndrome shows overlapping features of the following
three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome10/97 Novoseek disease relationships for PTEN gene (see all 97
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cowden disease |
96.24 |
254 |
16007494 (5), 14675182 (4), 11918710 (3), 12620973 (3) (see all 99) |
| bannayan-zonana syndrome |
89.86 |
20 |
10232405 (2), 9241266 (1), 9620558 (1), 11964046 (1) (see all 18) |
| glioblastoma |
83.86 |
249 |
9690672 (9), 9426052 (8), 19190120 (6), 12904991 (6) (see all 99) |
| tumors |
81.24 |
2022 |
9605750 (8), 12684422 (7), 16027168 (6), 11595133 (6) (see all 99) |
| juvenile polyposis syndrome |
81.08 |
8 |
9399897 (1), 11005140 (1), 9661881 (1), 15378062 (1) (see all 7) |
| endometrial carcinoma |
80.98 |
248 |
19224164 (8), 12001116 (6), 17009632 (6), 10851265 (5) (see all 86) |
| macrocephaly |
77.42 |
48 |
17427195 (5), 15805158 (4), 17286265 (3), 19265751 (3) (see all 20) |
| proteus syndrome |
76.90 |
28 |
15372512 (4), 18431376 (2), 17483958 (2), 16704655 (2) (see all 19) |
| cancer |
75.33 |
573 |
12370746 (6), 15132901 (4), 19285250 (4), 18794882 (4) (see all 99) |
| hamartoma |
75.17 |
52 |
18986487 (3), 18794875 (2), 18781191 (2), 9467011 (2) (see all 38) |
About this table
2 PharmGKB disease relationships for PTEN geneAbout this table
GeneTests: PTEN
PTEN Hamartoma Tumor Syndrome (PHTS)
Human Gene Mutation Database: PTEN
Genetic Association Database: PTEN
Human Genome Epidemiology Navigator: PTEN (61 documents)
|
Medical News
for PTEN(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for PTEN (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1731 PubMed articles for PTEN gene (see all 1731
):- Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. (PubMed id 15805158)1, 3, 4, 6 Butler M.G....Eng C. (2005)
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. (PubMed id 9090379)1, 2, 3, 4 Steck P.A.... Tavtigian S.V. (1997)
- The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. (PubMed id 9345101)3, 4, 6 Tsou H.C.... Peacocke M. (1997)
- Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. (PubMed id 15951562)1, 3, 4 Valiente M.... Pulido R. (2005)
- Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. (PubMed id 11707428)1, 3, 4 Vazquez F....Sellers W.R. (2001)
- PTEN coordinates G1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. (PubMed id 11230179)1, 3, 4 Weng L.-P.... Eng C. (2001)
- Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. (PubMed id 9635567)1, 3, 4 Maxwell G.L.... Futreal P.A. (1998)
- TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. (PubMed id 9187108)1, 3, 4 Li D.M. and Sun H. (1997)
- PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. (PubMed id 14642363)1, 3, 6 Kato H....Yoshimoto T. (2004)
- PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. (PubMed id 11504770)1, 3, 6 Smith J.S....Jenkins R.B. (2001)
|
Search for PTEN
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PTEN
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PTEN
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PTEN(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| ATLAS Chromosomes in Cancer entry for PTEN | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.genetests.org/query?gene=PTEN | | NIEHS-SNPs | http://egp.gs.washington.edu/data/pten/ |
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| | | About This Section
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| Services
for PTEN(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
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Products for PTEN:
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 | Antibodies & Assays for PTEN |
| | | Recombinant Proteins
(PTEN) | | | Antibodies (PTEN) |
| | | | Search Tocris compounds for PTEN |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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